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Metabolism: Clinical and Experimental

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https://www.readbyqxmd.com/read/29777715/association-between-plasma-ceramides-and-inducible-myocardial-ischemia-in-patients-with-established-or-suspected-coronary-artery-disease-undergoing-myocardial-perfusion-scintigraphy
#1
Alessandro Mantovani, Stefano Bonapace, Gianluigi Lunardi, Matteo Salgarello, Clementina Dugo, Guido Canali, Christopher D Byrne, Stefania Gori, Enrico Barbieri, Giovanni Targher
BACKGROUND: Recent studies have suggested that specific plasma ceramides are independently associated with major adverse cardiovascular events in patients with coronary artery disease (CAD), but it is currently unknown whether plasma ceramide levels are associated with stress-induced reversible myocardial ischemia. METHODS: We measured six previously identified high-risk plasma ceramide molecules [Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), Cer(d18:1/24:0), and Cer(d18:1/24:1)] in 167 consecutive patients with established or suspected CAD who underwent either exercise or dypiridamole myocardial perfusion scintigraphy (MPS) for various clinical indications...
May 16, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29775644/redox-signal-mediated-trpm2-promotes-ang-ii-induced-adipocyte-insulin-resistance-via-ca-2-dependent-camkii-jnk-cascade
#2
Min Gao, Yu Du, Jing-Wen Xie, Jing Xue, Yi-Ting Wang, Li Qin, Ming-Ming Ma, Yong-Bo Tang, Xiao-Yan Li
BACKGROUND AND OBJECTIVE: Redox-sensitive transient receptor potential melastatin 2 (TRPM2) is a Ca2+ -permeable, nonselective cation channel which plays a crucial role in various physiological processes. However, little is known whether TRPM2 is involved in adipocyte dysfunction during hypertension. In the present study, we determined the role of TRPM2 in angiotensin II (Ang II)-induced insulin resistance in adipocytes and the underlying mechanisms. METHODS: Ang II-induced adipocyte insulin resistant model was conducted...
May 15, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29752955/skeletal-muscle-specific-sidt2-knockout-in-mice-induced-muscular-dystrophy-like-phenotype
#3
Huan Liu, Wenjun Jiang, Xueru Chen, Guoying Chang, Lei Zhao, Xihua Li, Huiwen Zhang
BACKGROUND: Sidt2 is an integral lysosomal membrane protein. Previously, we generated a Sidt2 global knockout mouse and found impaired insulin secretion, along with skeletal muscle pathology. METHODS: A mouse model with a muscle-specific knockout of the Sidt2 gene (Sidt2f/f Cre) had been generated, to which extensive morphologic study as well as functional study was applied to investigate the direct role of Sidt2 on skeletal muscle tissue in vivo. Secondly, the autophagy-lysosomal pathway was examined by Western blot and immunostaining...
May 9, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29752954/regulation-of-the-activins-follistatins-inhibins-axis-by-energy-status-impact-on-reproductive-function
#4
Nikolaos Perakakis, Jagriti Upadhyay, Wael Ghaly, Joyce Chen, Pavlina Chrysafi, Athanasios D Anastasilakis, Christos S Mantzoros
BACKGROUND: We have previously demonstrated that the adipose tissue derived hormone leptin controls reproductive function by regulating the hypothalamic-pituitary-gonadal axis in response to energy deficiency. Here, we evaluate the activins-follistatins-inhibins (AFI) axis during acute (short-term fasting in healthy people) and chronic energy deficiency (women with hypothalamic amenorrhea due to strenuous exercise [HA]) and investigate their relation to leptin and reproductive function in healthy subjects and subjects with HA...
May 9, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29751019/nighttime-light-exposure-enhances-rev-erb%C3%AE-targeting-micrornas-and-contributes-to-hepatic-steatosis
#5
Patricia C Borck, Thiago M Batista, Jean F Vettorazzi, Gabriela M Soares, Camila Lubaczeuski, Dongyin Guan, Antonio C Boschero, Elaine Vieira, Mitchell A Lazar, Everardo M Carneiro
OBJECTIVE: The exposure to artificial light at night (ALAN) disrupts the biological rhythms and has been associated with the development of metabolic syndrome. MicroRNAs (miRNAs) display a critical role in fine-tuning the circadian system and energy metabolism. In this study, we aimed to assess whether altered miRNAs expression in the liver underlies metabolic disorders caused by disrupted biological rhythms. RESULTS: We found that C3H/HePas mice exposed to ALAN developed obesity, and hepatic steatosis, which was paralleled by decreased expression of Rev-erbα and up-regulation of its lipogenic targets ACL and FAS in liver...
May 8, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29733820/considerations-to-facilitate-a-us-study-that-replicates-predimed
#6
REVIEW
David R Jacobs, Kristina S Petersen, Karianne Svendsen, Emilio Ros, Carol B Sloan, Lyn M Steffen, Linda C Tapsell, Penny M Kris-Etherton
The PREDIMED clinical trial provided strong evidence that a Mediterranean dietary pattern (MedDiet) could help prevent cardiovascular disease (CVD) events in high risk middle-aged/older people. This report considers the feasibility of replicating PREDIMED in the U.S., including recommendations for dietary and behavioral principles. A 14-point Mediterranean Diet Adherence Score (MEDAS) guided the PREDIMED MedDiet recommendations. At baseline MEDAS points were ~8.5. During intervention this score increased to nearly 11 in MedDiet vs...
May 4, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29729227/metformin-and-risk-of-developing-nasopharyngeal-cancer-in-patients-with-type-2-diabetes-mellitus
#7
Chin-Hsiao Tseng
BACKGROUND: Metformin has anticancer effects, but whether it can reduce the risk of nasopharyngeal cancer (NPC) is not known. METHODS: A total of 15,486 ever-users and 15,486 never-users of metformin matched by propensity score were enrolled from among patients with new-onset type 2 diabetes mellitus diagnosed during the period 1999-2005 and who were found in the reimbursement database of Taiwan's National Health Insurance. The patients were followed until December 31, 2011...
May 2, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29727630/theacrine-protects-against-nonalcoholic-fatty-liver-disease-by-regulating-acylcarnitine-metabolism
#8
Guo-En Wang, Yi-Fang Li, Yu-Jia Zhai, Lian Gong, Jing-Yu Tian, Mo Hong, Nan Yao, Yan-Ping Wu, Hiroshi Kurihara, Rong-Rong He
OBJECTIVE: Acylcarnitine metabolism disorder contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). There are, however, few ideal medications for NAFLD, which work by targeting acylcarnitine metabolism. The aim of this study was to investigate the protective effects of theacrine, a rare purine alkaloid isolated from Camellia assamica var. kucha, against acylcarnitine metabolism disorder in NAFLD. METHODS: The pharmacological activities of theacrine were studied using high-fat diet (HFD)-fed ApoE-/- and C57BL/6 J mice models...
May 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29727629/losartan-prevents-the-imbalance-between-renal-dopaminergic-and-renin-angiotensin-systems-induced-by-fructose-overload-l-dopa-dopamine-index-as-new-potential-biomarker-of-renal-dysfunction
#9
Natalia Lucía Rukavina Mikusic, Nicolás Martín Kouyoumdzian, Ana Uceda, Julieta Sofía Del Mauro, Marcela Pandolfo, Mariela Mercedes Gironacci, Ana María Puyó, Jorge Eduardo Toblli, Belisario Enrique Fernández, Marcelo Roberto Choi
BACKGROUND: The renin angiotensin system (RAS) and the renal dopaminergic system (RDS) act as autocrine and paracrine systems to regulate renal sodium management and inflammation and their alterations have been associated to hypertension and renal damage. Nearly 30-50% of hypertensive patients have insulin resistance (IR), with a strong correlation between hyperinsulinemia and microalbuminuria. OBJECTIVE: The aim of this study was to demonstrate the existence of an imbalance between RAS and RDS associated to IR, hypertension and kidney damage induced by fructose overload (FO), as well as to establish their prevention, by pharmacological inhibition of RAS with losartan...
May 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29727628/extracellular-vesicles-characteristics-and-emerging-roles-in-atherosclerotic-cardiovascular-disease
#10
REVIEW
Hafiane Anouar, Stella S Daskalopoulou
The term extracellular vesicles (EVs) describes membrane vesicles released into the extracellular space by most cell types. EVs have been recognized to play an important role in cell-to-cell communication. They are known to contain various bioactive molecules, including proteins, lipids, and nucleic acids. Although the nomenclature of EVs is not entirely standardized, they are considered to include exosomes, microparticles or microvesicles and apoptotic bodies. EVs are believed to play important roles in a wide range of biological processes...
May 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29715464/spermidine-spermine-n1-acetyltransferase-mediated-polyamine-catabolism-regulates-beige-adipocyte-biogenesis
#11
Fang Yuan, Lin Zhang, Yang Cao, Wei Gao, Can Zhao, Yuan Fang, Kamyar Zahedi, Manoocher Soleimani, Xiang Lu, Zhuyuan Fang, Qin Yang
OBJECTIVE: Cold and β3-adrenergic receptor (AR) agonists activate beige adipocyte biogenesis in white adipose tissue (WAT). The two stimuli also induce expression of inflammatory cytokines in WAT. The low-grade inflammation may further promote WAT browning. However, the mechanisms to reconcile these two biological processes remain to be elucidated. In this study, we aim to investigate the roles of the rate-limiting polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase (SAT1) in regulating beige adipocyte biogenesis and inflammation...
April 28, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29679615/novel-protective-role-of-kallistatin-in-obesity-by-limiting-adipose-tissue-low-grade-inflammation-and-oxidative-stress
#12
Gema Frühbeck, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Sara Becerril, Xabier Unamuno, Camilo Silva, Javier Salvador, Victoria Catalán
OBJECTIVE: Kallistatin plays an important role in the inhibition of inflammation, oxidative stress, fibrosis and angiogenesis. We aimed to determine the impact of kallistatin on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and oxidative stress. METHODS: Samples obtained from 95 subjects were used in a case-control study. Circulating concentrations and expression levels of kallistatin as well as key inflammation, oxidative stress and extracellular matrix remodelling-related genes were analyzed...
April 18, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29669261/chrebp-deficiency-leads-to-diarrhea-predominant-irritable-bowel-syndrome
#13
Ah-Reum Oh, Seonyong Sohn, Junghoon Lee, Jong-Min Park, Ki Taek Nam, Ki-Baik Hahm, Young-Bum Kim, Ho-Jae Lee, Ji-Young Cha
OBJECTIVE: Fructose malabsorption is a common digestive disorder in which absorption of fructose in the small intestine is impaired. An abnormality of the main intestinal fructose transporter proteins has been proposed as a cause for fructose malabsorption. However the underlying molecular mechanism for this remains unclear. In this study, we investigated whether carbohydrate response element-binding protein (ChREBP) plays a role in intestinal fructose absorption through the regulation of genes involved in fructose transport and metabolism and ion transport...
April 15, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29660453/tgf-%C3%AE-1-down-regulation-in-the-mediobasal-hypothalamus-attenuates-hypothalamic-inflammation-and-protects-against-diet-induced-obesity
#14
Natália F Mendes, Joana M Gaspar, José C Lima-Júnior, Jose Donato, Lício A Velloso, Eliana P Araújo
BACKGROUND: The consumption of large amounts of dietary fats induces hypothalamic inflammation and impairs the function of the melanocortin system, leading to a defective regulation of caloric intake and whole-body energy expenditure. In mice fed a high-fat diet (HFD), TGF-β1 expression was increased and NF-κB signaling was activated in proopiomelanocortin neurons, which plays an important role in the obesity-associated hypothalamic inflammation scenario. However, whether excessive hypothalamic TGF-β1 impairs energy homeostasis remains unclear...
April 13, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29656048/trunk-muscle-quality-assessed-by-computed-tomography-association-with-adiposity-indices-and-glucose-tolerance-in-men
#15
Alexandre Maltais, Natalie Alméras, Isabelle Lemieux, Angelo Tremblay, Jean Bergeron, Paul Poirier, Jean-Pierre Després
BACKGROUND/OBJECTIVES: Thigh muscle attenuation measured by computed tomography (CT) has been shown to be a reliable and useful index of skeletal muscle fat infiltration. Thigh muscle fat content assessed by CT has been linked to obesity and type 2 diabetes and is a correlate of insulin resistance in sedentary individuals. However, as measurement of mid-thigh fat content requires the assessment of another region of interest beyond the usual abdominal scan required to measure levels of visceral and subcutaneous abdominal adipose tissue, this study aimed at testing the hypothesis that skeletal muscle fat measured from a single abdominal scan (L4 -L5 ) would also provide information relevant to the estimation of muscle fat infiltration as it relates to cardiometabolic risk...
April 12, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29656047/the-complex-association-between-metabolic-syndrome-and-male-hypogonadism
#16
Christina Dimopoulou, Dimitrios G Goulis, Giovanni Corona, Mario Maggi
BACKGROUND: The complex association between metabolic syndrome (MetS) and male hypogonadism is well established. A number of observational studies show that low testosterone is associated with insulin resistance and an increased risk for diabetes mellitus and MetS in men. AIMS: To elucidate the association between MetS and male hypogonadism, present epidemiological data on the co-existence of the two comorbidities, enlighten the underlying pathophysiology and appraise the effects of testosterone supplementation therapy (TTh) and lifestyle modifications on MetS and body composition in men...
April 12, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29634954/advances-at-the-intersection-of-sleep-and-metabolism-research
#17
EDITORIAL
Olivia M Farr, Christos S Mantzoros
No abstract text is available yet for this article.
April 7, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29634953/circular-rna-expression-profiles-of-mouse-ovaries-during-postnatal-development-and-the-function-of-circular-rna-epidermal-growth-factor-receptor-in-granulosa-cells
#18
Wenchao Jia, Bo Xu, Ji Wu
PURPOSE: Circular RNAs (circRNAs) are a class of noncoding RNAs that can regulate gene expression at the post-transcriptional level. The contribution of circRNAs in the regulation of granulosa cells (GCs) functions is not yet clear. The aim of this study was to analyze circRNA expression in adult and neonate ovaries, uncover the biological roles of circ_0002861 (circEGFR) and identify the mechanism by which it modulates follicular development. BASIC PROCEDURES: The circRNA expression profiles of adult and neonatal mouse ovaries were explored by high-throughput sequencing...
April 7, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29630921/association-of-sleep-disturbances-with-obesity-insulin-resistance-and-the-metabolic-syndrome
#19
Dorit Koren, Elsie M Taveras
Insufficient sleep, which has become endemic in recent years, has been variably associated with increased risk of obesity, disorders of glucose and insulin homeostasis, and the metabolic syndrome; to a lesser degree, so has excessive sleep. This review summarizes recent epidemiological and pathophysiological evidence linking sleep disturbances (primarily abnormalities of sleep duration) with obesity, insulin resistance, type 2 diabetes and the metabolic syndrome in children and adults.
April 6, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29627447/gestational-diabetes-mellitus-multi-disciplinary-treatment-approaches
#20
Evangelia Kintiraki, Dimitrios G Goulis
Gestational Diabetes Mellitus (GDM) is the most common metabolic disease of pregnancy, associated with several perinatal complications. Adequate glycemic control has been proved to decrease risk of GDM-related complications. Several studies have shown the beneficial effect of exercise and medical nutrition treatment on glycemic and weight control in GDM-affected women. Moreover, pharmacological agents, such as insulin and specific oral anti-diabetic agents can be prescribed safely during pregnancy, decreasing maternal blood glucose and, thus, perinatal adverse outcomes...
April 5, 2018: Metabolism: Clinical and Experimental
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