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Metabolism: Clinical and Experimental

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https://www.readbyqxmd.com/read/27912896/corrigendum-to-variants-of-the-adiponectin-gene-and-diabetic-microvascular-complications-in-patients-with-type-2-diabetes-metab-clin-exp-62-2013-677-685
#1
Eun Yeong Choe, Hye Jin Wang, Obin Kwon, Kwang Joon Kim, Bum Seok Kim, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Eun Seok Kang, Christos S Mantzoros
No abstract text is available yet for this article.
November 29, 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27842716/response-letter-statins-and-non-alcoholic-steatohepatitis
#2
LETTER
Vasilios G Athyros, Niki Katsiki, Dimitri P Mikhailidis
No abstract text is available yet for this article.
October 29, 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27836113/statins-and-non-alcoholic-steatohepatitis
#3
LETTER
Vasilios G Athyros, Niki Katsiki, Dimitri P Mikhailidis
No abstract text is available yet for this article.
October 26, 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27865560/reply-to-statins-and-non-alcoholic-steatohepatitis
#4
LETTER
Diana Barb, Kenneth Cusi
No abstract text is available yet for this article.
October 24, 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27832864/impaired-adipose-tissue-lipid-storage-but-not-altered-lipolysis-contributes-to-elevated-levels-of-nefa-in-type-2-diabetes-degree-of-hyperglycemia-and-adiposity-are-important-factors
#5
Maria J Pereira, Stanko Skrtic, Petros Katsogiannos, Niclas Abrahamsson, Cherno O Sidibeh, Santosh Dahgam, Marianne Månsson, Ulf Risérus, Joel Kullberg, Jan W Eriksson
BACKGROUND: Elevated levels of circulating non-esterified fatty acids (NEFA) mediate many adverse metabolic effects. In this work we aim to determine the impact of type 2 diabetes (T2D), glycemic control and obesity on lipolysis regulation. DESIGN AND PARTICIPANTS: 20 control and 20 metformin-treated T2D subjects were matched for sex (10M/10 F), age (58±11 vs 58±9 y) and BMI (30.8±4.6 vs 30.7±4.9kg/m(2)). In vivo lipolysis was assessed during a 3h-OGTT with plasma glycerol and NEFA levels...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27832863/endothelial-progenitor-cells-from-human-fetal-aorta-cure-diabetic-foot-in-a-rat-model
#6
Wan-Ni Zhao, Shi-Qing Xu, Jian-Feng Liang, Liang Peng, Hong-Lin Liu, Zai Wang, Qing Fang, Meng Wang, Wei-Qin Yin, Wen-Jian Zhang, Jin-Ning Lou
OBJECTIVE: Recent evidence has suggested that circulating endothelial progenitor cells (EPCs) can repair the arterial endothelium during vascular injury. However, a reliable source of human EPCs is needed for therapeutic applications. In this study, we isolated human fetal aorta (HFA)-derived EPCs and analyzed the capacity of EPCs to differentiate into endothelial cells. In addition, because microvascular dysfunction is considered to be the major cause of diabetic foot (DF), we investigated whether transplantation of HFA-derived EPCs could treat DF in a rat model...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27832862/time-restricted-feeding-improves-insulin-resistance-and-hepatic-steatosis-in-a-mouse-model-of-postmenopausal-obesity
#7
Heekyung Chung, Winjet Chou, Dorothy D Sears, Ruth E Patterson, Nicholas J G Webster, Lesley G Ellies
BACKGROUND: Menopause is associated with significant hormonal changes that result in increased total body fat and abdominal fat, amplifying the risk for metabolic syndrome and diseases such as diabetes, cardiovascular disease and cancer in postmenopausal women. Intermittent fasting regimens hold significant health benefit promise for obese humans, however, regimens that include extreme daytime calorie restriction or daytime fasting are generally associated with hunger and irritability, hampering long-term compliance and adoption in the clinical setting...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27832861/perilipin-1-binds-to-aquaporin-7-in-human-adipocytes-and-controls-its-mobility-via-protein-kinase-a-mediated-phosphorylation
#8
Jesper S Hansen, Christian Krintel, Malin Hernebring, Tatu J K Haataja, Sofia de Marè, Sebastian Wasserstrom, Urszula Kosinska-Eriksson, Madelene Palmgren, Cecilia Holm, Karin G Stenkula, Helena A Jones, Karin Lindkvist-Petersson
Accumulating evidence suggests that dysregulated glycerol metabolism contributes to the pathophysiology of obesity and type 2 diabetes. Glycerol efflux from adipocytes is regulated by the aquaglyceroporin AQP7, which is translocated upon hormone stimulation. Here, we propose a molecular mechanism where the AQP7 mobility in adipocytes is dependent on perilipin 1 and protein kinase A. Biochemical analyses combined with ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27832860/adiponectin-administration-prevents-weight-gain-and-glycemic-profile-changes-in-diet-induced-obese-immune-deficient-rag1-mice-lacking-mature-lymphocytes
#9
Xiaowen Liu, Nikolaos Perakakis, Huizhi Gong, John P Chamberland, Mary T Brinkoetter, Ole-Petter R Hamnvik, Christos S Mantzoros
BACKGROUND: Obesity is associated with chronic low-grade inflammation leading to insulin resistance and diabetes. Adiponectin is an adipokine that regulates inflammatory responses. The aim of our study was to investigate whether any effects of adiponectin against obesity and insulin-resistance may depend on the adaptive immune system. METHODS: We treated high-fat-diet fed Rag1-/- mice lacking mature lymphocytes with adiponectin over 7weeks and investigated alterations in their metabolic outcome and inflammatory state...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27832859/dietary-fat-drives-whole-body-insulin-resistance-and-promotes-intestinal-inflammation-independent-of-body-weight-gain
#10
Benjamin A H Jensen, Thomas S Nielsen, Andreas M Fritzen, Jacob B Holm, Even Fjære, Annette K Serup, Kamil Borkowski, Steve Risis, Simone I Pærregaard, Ida Søgaard, Audrey Poupeau, Michelle Poulsen, Tao Ma, Christian Sina, Bente Kiens, Lise Madsen, Karsten Kristiansen, Jonas T Treebak
BACKGROUND: The obesogenic potential of high-fat diets (HFD) in rodents is attenuated when the protein:carbohydrate ratio is increased. However, it is not known if intake of an HFD irrespective of the protein:carbohydrate ratio and in the absence of weight gain, affects glucose homeostasis and the gut microbiota. METHODS: We fed C57BL6/J mice 3 different HFDs with decreasing protein:carbohydrate ratios for 8weeks and compared the results to a LFD reference group...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27832858/effects-of-equivalent-sympathetic-activation-during-hypoglycemia-on-endothelial-function-and-pro-atherothrombotic-balance-in-healthy-individuals-and-obese-standard-treated-type-2-diabetes
#11
Nino G Joy, Maia Mikeladze, Lisa M Younk, Donna B Tate, Stephen N Davis
OBJECTIVE: Recent studies in type 2 diabetes have reported an association between hypoglycemia and severe cardiovascular adverse events, which are relatively increased in standard versus intensively treated individuals. The aim of this study was to determine the effects of equivalent sympathetic nervous system (SNS) activity during moderate hypoglycemia on in-vivo endothelial function, pro-inflammatory, pro-atherothrombotic, and pro-coagulant responses in healthy and standard treated type 2 diabetes individuals...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27733255/effect-of-extended-release-niacin-on-plasma-lipoprotein-a-levels-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#12
Amirhosssein Sahebkar, Željko Reiner, Luis E Simental-Mendía, Gianna Ferretti, Arrigo F G Cicero
AIM: Lipoprotein(a) (Lp(a)) is a proatherogenic and prothrombotic lipoprotein. Our aim was to quantify the extended-release nicotinic acid Lp(a) reducing effect with a meta-analysis of the available randomized clinical trials. METHODS: A meta-analysis and random-effects meta-regression were performed on data pooled from 14 randomized placebo-controlled clinical trials published between 1998 and 2015, comprising 17 treatment arms, which included 9013 subjects, with 5362 in the niacin arm...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27733254/fat-accumulation-in-the-tongue-is-associated-with-male-gender-abnormal-upper-airway-patency-and-whole-body-adiposity
#13
Ivan R B Godoy, Edgar Leonardo Martinez-Salazar, Alireza Eajazi, Pedro R Genta, Miriam A Bredella, Martin Torriani
OBJECTIVE: To examine associations between tongue adiposity with upper airway measures, whole-body adiposity and gender. We hypothesized that increased tongue adiposity is higher in males and positively associated with abnormal upper airway measures and whole-body adiposity. METHODS: We studied subjects who underwent whole-body positron emission tomography/computed tomography to obtain tongue attenuation (TA) values and cross-sectional area, pharyngeal length (PL) and mandibular plane to hyoid distance (MPH), as well as abdominal circumference, abdominal subcutaneous and visceral (VAT) adipose tissue areas, neck circumference (NC) and neck adipose tissue area...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27733253/glycerol-3-phosphate-dehydrogenase-1-deficiency-induces-compensatory-amino-acid-metabolism-during-fasting-in-mice
#14
Tomoki Sato, Yuma Yoshida, Akihito Morita, Nobuko Mori, Shinji Miura
BACKGROUND: Glucose is used as an energy source in many organs and obtained from dietary carbohydrates. However, when the external energy supply is interrupted, e.g., during fasting, carbohydrates preserved in the liver and glycogenic precursors derived from other organs are used to maintain blood glucose levels. Glycerol and glycogenic amino acids derived from adipocytes and skeletal muscles are utilized as glycogenic precursors. Glycerol-3-phosphate dehydrogenase 1 (GPD1), an NAD(+)/NADH-dependent enzyme present in the cytosol, catalyzes the reversible conversion of glycerol-3-phosphate (G3P) to dihydroxyacetone phosphate (DHAP)...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27733252/effects-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-on-cardiovascular-disease-risk-factors-a-randomized-clinical-trial
#15
Ivor B Asztalos, Joi A Gleason, Sakine Sever, Reyhan Gedik, Bela F Asztalos, Katalin V Horvath, Michael L Dansinger, Stefania Lamon-Fava, Ernst J Schaefer
BACKGROUND: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the primary omega-3 fatty acids in fish oil, have been shown to reduce cardiovascular disease (CVD) risk. OBJECTIVE: This study aimed to examine the independent effects of EPA and DHA on lipid and apolipoprotein levels, as well as on inflammatory biomarkers of CVD risk, using doses often used in the general population. DESIGN: A blinded, randomized 6-week trial was performed in 121 healthy, normolipidemic subjects who received olive oil placebo 6g/d, EPA 600mg/d, EPA 1800mg/d, or DHA 600mg/d...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27733251/change-in-serum-albumin-concentration-is-inversely-and-independently-associated-with-risk-of-incident-metabolic-syndrome
#16
Sang-Man Jin, Yong Joo Hong, Jae Hwan Jee, Ji Cheol Bae, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
BACKGROUND: Low serum albumin concentration is associated with a high risk of morbidity and mortality from cardiovascular diseases. However, high serum albumin level appears to be linked to metabolic syndrome (MetS). This study aimed to dissect the relative contributions of baseline and change in serum albumin concentration to the risk of incident metabolic syndrome. METHODS: This was a 5-year (63,060 person-years) retrospective longitudinal study of 12,567 participants without metabolic syndrome, diabetes, or cardiovascular disease who were enrolled in a health screening program...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27733250/a-human-model-of-dietary-saturated-fatty-acid-induced-insulin-resistance
#17
Juraj Koska, Marlies K Ozias, James Deer, Julie Kurtz, Arline D Salbe, S Mitchell Harman, Peter D Reaven
BACKGROUND: Increased consumption of high-fat diets is associated with the development of insulin resistance and type 2 diabetes. Current models to study the mechanisms of high-fat diet-induced IR in humans are limited by their long duration or low efficacy. In the present study we developed and characterized an acute dietary model of saturated fatty acid-enriched diet induced insulin resistance. METHODS: High caloric diets enriched with saturated fatty acids (SFA) or carbohydrates (CARB) were evaluated in subjects with normal and impaired glucose tolerance (NGT or IGT)...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27733249/weight-loss-induced-by-very-low-calorie-diet-is-associated-with-a-more-beneficial-systemic-inflammatory-profile-than-by-roux-en-y-gastric-bypass
#18
Mirjam A Lips, Jan Bert van Klinken, Hanno Pijl, Ignace Janssen, Ko Willems van Dijk, Frits Koning, Vanessa van Harmelen
INTRODUCTION: Weight loss interventions such as Roux-en-Y gastric bypass (RYGB) and very low calorie diets (VLCD) lead to improvement of glucose metabolism in obese individuals with type-2 diabetes. Weight loss can also positively influence the unfavorable inflammatory profile associated with obesity. However, a direct comparison of the effect of VLCD and RYGB on systemic inflammation is lacking. METHODS: Systemic inflammation was investigated in age- and BMI-matched morbidly obese T2DM women by determining the number and activation- or memory status of peripheral blood leukocytes by flow cytometry, in addition to measuring circulating levels of cytokines and CRP...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27733248/effects-of-diet-composition-on-weight-loss-metabolic-factors-and-biomarkers-in-a-1-year-weight-loss-intervention-in-obese-women-examined-by-baseline-insulin-resistance-status
#19
Cheryl L Rock, Shirley W Flatt, Bilge Pakiz, Elizabeth L Quintana, Dennis D Heath, Brinda K Rana, Loki Natarajan
BACKGROUND: Obesity is a risk factor for postmenopausal breast cancer incidence and premenopausal and postmenopausal breast cancer mortality, which may be explained by several metabolic and hormonal factors (sex hormones, insulin resistance, and inflammation) that are biologically related. Differential effects of dietary composition on weight loss and these metabolic factors may occur in insulin-sensitive vs. insulin-resistant obese women. OBJECTIVE: To examine the effect of diet composition on weight loss and metabolic, hormonal and inflammatory factors in overweight/obese women stratified by insulin resistance status in a 1-year weight loss intervention...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27733247/klotho-response-to-treatment-with-growth-hormone-and-the-role-of-igf-i-as-a-mediator
#20
Tami Rubinek, Shiri Shahmoon, Ayelet Shabtay-Orbach, Michal Ben Ami, Yael Levy-Shraga, Kineret Mazor-Aronovitch, Yonatan Yeshayahu, Ram Doolman, Rina Hemi, Hannah Kanety, Ido Wolf, Dalit Modan-Moses
CONTEXT: Klotho is an aging-modulating protein expressed mainly in the kidneys, which can be cleaved and shed to act as a circulating hormone. Several lines of evidence suggest a tight interaction between klotho and the GH-IGF-I axis. We showed previously that klotho levels are decreased in pediatric patients with growth hormone deficiency (GHD). Our aim now is to investigate the effect of GH therapy on klotho levels in these patients and to elucidate the role of IGF-1 in mediating secretion of klotho...
November 2016: Metabolism: Clinical and Experimental
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