journal
MENU ▼
Read by QxMD icon Read
search

Metabolism: Clinical and Experimental

journal
https://www.readbyqxmd.com/read/28920863/white-matter-microstructure-and-cognitive-decline-in-metabolic-syndrome-a-review-of-diffusion-tensor-imaging
#1
REVIEW
Freddy J Alfaro, Anna Gavrieli, Patricia Saade, Vasileios-Arsenios Lioutas, Jagriti Upadhyay, Vera Novak
Metabolic syndrome is a cluster of cardiovascular risk factors defined by the presence of abdominal obesity, glucose intolerance, hypertension and/or dyslipidemia. It is a major public health epidemic worldwide, and a known risk factor for the development of cognitive dysfunction and dementia. Several studies have demonstrated a positive association between the presence of metabolic syndrome and worse cognitive outcomes, however, evidence of brain structure pathology is limited. Diffusion tensor imaging has offered new opportunities to detect microstructural white matter changes in metabolic syndrome, and a possibility to detect associations between functional and structural abnormalities...
September 8, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28920862/enhanced-endothelium-epithelial-sodium-channel-signaling-prompts-left-ventricular-diastolic-dysfunction-in-obese-female-mice
#2
Guanghong Jia, Javad Habibi, Annayya R Aroor, Michael A Hill, Vincent G DeMarco, Li E Lee, Lixin Ma, Brady J Barron, Adam Whaley-Connell, James R Sowers
OBJECTIVE: Enhanced activation of cell specific mineralocorticoid receptors (MRs) in obesity plays a key role in the development of cardiovascular disease including cardiac diastolic dysfunction as a critical prognosticator. Our previous investigations demonstrated that selective endothelium MR activation promotes a maladaptive inflammatory response and fibrosis in cardiovascular tissue in female mice fed a western diet (WD), and this was associated with expression and activation of the epithelial sodium channel on the surface of endothelial cells (EnNaC)...
September 8, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28920861/pharmacotherapy-of-type-2-diabetes-an-update
#3
REVIEW
Jagriti Upadhyay, Stergios A Polyzos, Nikolaos Perakakis, Bindiya Thakkar, Stavroula A Paschou, Niki Katsiki, Patricia Underwood, Kyung-Hee Park, Jochen Seufert, Eun Seok Kang, Elliot Sternthal, Asterios Karagiannis, Christos S Mantzoros
Type 2 diabetes (T2DM) is a leading cause of morbidity and mortality worldwide and a major economic burden. The prevalence of T2DM is rising, suggesting more effective prevention and treatment strategies are necessary. The aim of this narrative review is to summarize the pharmacologic treatment options available for patients with T2DM. Each therapeutic class is presented in detail, outlining medication effects, side effects, glycemic control, effect on weight, indications and contraindications, and use in selected populations (heart failure, renal insufficiency, obesity and the elderly)...
September 8, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28780255/paget-s-disease-of-bone
#4
Tim Cundy
Paget's disease is a chronic focal high turnover bone disorder that is primarily present in middle-aged or older adults. It seems to be restricted to humans and has no clear parallels with other diseases. Although much has been learnt about its pathology and epidemiology, and treatment is now highly effective we still lack a complete understanding of its etiology and biology. This review focusses on the natural history of the disorder, in particular its changing epidemiology, recent discoveries about its genetic basis and current approaches to diagnosis and treatment...
July 4, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28774733/current-child-but-not-maternal-snoring-is-bi-directionally-related-to-adiposity-and-cardiometabolic-risk-markers-a-cross-sectional-and-a-prospective-cohort-analysis
#5
Olivia M Farr, Sheryl L Rifas-Shiman, Emily Oken, Elsie M Taveras, Christos S Mantzoros
PURPOSE: Obstructive sleep apnea (OSA), typically manifested as snoring, is closely associated with obesity. However, the directionality of associations of OSA with cardiometabolic risk markers is unclear, as obesity increases risk for OSA, and OSA results in excess weight gain and its metabolic consequences. Less is known about how obesity and OSA may relate in children and adolescents and whether maternal OSA may influence the development of obesity and cardiometabolic dysfunction in offspring...
June 29, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28764846/uric-acid-promotes-vascular-stiffness-maladaptive-inflammatory-responses-and-proteinuria-in-western-diet-fed-mice
#6
Annayya R Aroor, Guanghong Jia, Javad Habibi, Zhe Sun, Francisco I Ramirez-Perez, Barron Brady, Dongqing Chen, Luis A Martinez-Lemus, Camila Manrique, Ravi Nistala, Adam T Whaley-Connell, Vincent G Demarco, Gerald A Meininger, James R Sowers
OBJECTIVE: Aortic vascular stiffness has been implicated in the development of cardiovascular disease (CVD) and chronic kidney disease (CKD) in obese individuals. However, the mechanism promoting these adverse effects are unclear. In this context, promotion of obesity through consumption of a western diet (WD) high in fat and fructose leads to excess circulating uric acid. There is accumulating data implicating elevated uric acid in the promotion of CVD and CKD. Accordingly, we hypothesized that xanthine oxidase(XO) inhibition with allopurinol would prevent a rise in vascular stiffness and proteinuria in a translationally relevant model of WD-induced obesity...
September 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28764845/impaired-calcium-sensing-distinguishes-primary-hyperparathyroidism-phpt-patients-with-low-bone-mineral-density
#7
Thomas J Weber, James Koh, Samantha M Thomas, Joyce A Hogue, Randall P Scheri, Sanziana A Roman, Julie A Sosa
CONTEXT: A subset of PHPT patients exhibit a more severe disease phenotype characterized by bone loss, fractures, recurrent nephrolithiasis, and other dysfunctions, but the underlying reasons for this disparity in clinical presentation remain unknown. OBJECTIVE: We sought to identify new mechanistic indices that could inform more personalized management of PHPT. DESIGN: Pre-, peri-, and postoperative data and demographic, clinical, and pathological information from patients undergoing parathyroidectomy for PHPT were collected...
September 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28764844/biliopancreatic-diversion-with-duodenal-switch-leads-to-better-postprandial-glucose-level-and-beta-cell-function-than-sleeve-gastrectomy-in-individuals-with-type-2-diabetes-very-early-after-surgery
#8
Andréanne Michaud, Thomas Grenier-Larouche, Dominique Caron-Dorval, Simon Marceau, Laurent Biertho, Serge Simard, Denis Richard, André Tchernof, André C Carpentier
OBJECTIVE: The aim of this study was to compare the short-term effect of sleeve gastrectomy (SG) and biliopancreatic diversion with duodenal switch (DS) in order to determine if exclusion of the upper gastrointestinal tract confers greater metabolic improvement, independent of weight loss. METHODS: Standard meals were administered before and on day 3 and 4 after SG to assess insulin sensitivity, β-cell function and gastrointestinal hormone responses in matched normoglycemic (NG) and type 2 diabetes (T2D) participants...
September 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28764843/current-role-of-the-nlrp3-inflammasome-on-obesity-and-insulin-resistance-a-systematic-review
#9
REVIEW
Jakeline Rheinheimer, Bianca M de Souza, Natali S Cardoso, Andrea C Bauer, Daisy Crispim
NLRP3 inflammasome activation seems to be a culprit behind the chronic inflammation characteristic of obesity and insulin resistance (IR). Nutrient excess generates danger-associated molecules that activate NLRP3 inflammasome-caspase 1, leading to maturation of IL-1β and IL-18, which are proinflammatory cytokines released by immune cells infiltrating the adipose tissue (AT) from obese subjects. Although several studies have reported an association of the NLRP3 inflammasome with obesity and/or IR; contradictory results were also reported by other studies...
September 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28095989/prolonged-k-deficiency-increases-intracellular-atp-cell-cycle-arrest-and-cell-death-in-renal-tubular-cells
#10
Kedsarin Fong-Ngern, Nardtaya Ausakunpipat, Nilubon Singhto, Kanyarat Sueksakit, Visith Thongboonkerd
BACKGROUND: Chronic potassium (K(+)) deficiency can cause renal damage namely hypokalemic nephropathy with unclear pathogenic mechanisms. In the present study, we investigated expression and functional alterations in renal tubular cells induced by prolonged K(+) deficiency. METHODS: MDCK cells were maintained in normal-K(+) (CNK) (K(+)=5.3mmol/L), low-K(+) (CLK) (K(+)=2.5mmol/L), or K(+)-depleted (CKD) (K(+)=0mmol/L) medium for 10days (n=5 independent cultures/condition)...
September 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732575/beraprost-sodium-a-prostacyclin-analogue-reduces-fructose-induced-hepatocellular-steatosis-in-mice-and-in-vitro-via-the-microrna-200a-and-sirt1-signaling-pathway
#11
Pengyuan Zhang, Lijuan Xu, Hongyu Guan, Liehua Liu, Juan Liu, Zhimin Huang, Xiaopei Cao, Zhihong Liao, Haipeng Xiao, Yanbing Li
PURPOSE: To determine whether beraprost sodium, a prostacyclin analogue, could reduce hepatic lipid accumulation induced by fructose in mice and cultured human hepatocytes, and to investigate the expression of microRNAs and the sirtuin 1 (SIRT1) pathway. METHODS: Male C57BL/6JNju mice were divided into three groups and fed one of the following diets: a normal diet, a high fructose diet, or a high fructose diet with beraprost sodium treatment. In addition, human-derived HepG2 cells were cultured and treated with fructose (25mmol/L) with or without beraprost sodium (10μmol/L) for 24h, and transfected with small interfering RNA (siRNA) against SIRT1, miR-200a mimic, or miR-200a inhibitor for 48h...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732574/albiflorin-ameliorates-obesity-by-inducing-thermogenic-genes-via-ampk-and-pi3k-akt-in-vivo-and-in-vitro
#12
Mi-Young Jeong, Jinbong Park, Dong-Hyun Youn, Yunu Jung, JongWook Kang, Seona Lim, Min-Woo Kang, Hye-Lin Kim, Hong-Seob So, Raekil Park, Seung-Heon Hong, Jae-Young Um
OBJECTIVE: Brown adipose tissue (BAT) activation has been identified as a possible target to treat obesity and to protect against metabolic diseases by increasing energy consumption. We explored whether albiflorin (AF), a natural compound, could contribute to lowering the high risk of obesity with BAT and primary brown preadipocytes in vivo and in vitro. MATERIALS/METHODS: Human adipose tissue-derived mesenchymal stem cells (hAMSCs) were cultured with adipogenic differentiation media with or without AF...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732573/the-association-between-immunoglobulin-concentrations-and-prediabetes-prevalence-in-a-large-chinese-cohort
#13
Honglei Wang, Yanqi Song, Shaomei Sun, Li Gao, Li Liu, Ge Meng, Hongmei Wu, Yang Xia, Xue Bao, Yeqing Gu, Hongbin Shi, Qian Su, Liyun Fang, Huijun Yang, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Qing Zhang, Kaijun Niu
AIMS: Prediabetes has received public attention owing to the increasing prevalence worldwide. Mounting evidence has indicated that inflammation directly contributed to the etiology of glucose metabolism disorders. Although immunoglobulins play a crucial role in immune responses, little research has been done on the link between immunoglobulins and prediabetes in adults. Hence, the aim of the present study was to explore the associations between immunoglobulins levels and prevalence of prediabetes in a general adult population...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732572/vitamin-d-supplementation-and-glycemic-control-in-type-2-diabetes-patients-a-systematic-review-and-meta-analysis
#14
Chunhua Wu, Shanhu Qiu, Xiangyun Zhu, Ling Li
INTRODUCTION: Low vitamin D status has been found to be associated with impaired glycemic control in patients who suffer from type 2 diabetes; however, whether vitamin D supplementation is associated with improved glycemic status remains controversial. The aim of this study was to summarize evidence from randomized controlled trials (RCTs) to assess the efficacy of vitamin D supplementation in reducing glycosylated haemoglobinA1c (HbA1c) and fasting blood glucose (FBG) levels. MATERIALS/METHODS: We searched PubMed, Web of Science and the Cochrane Library for reports published up to March 2017...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732571/examining-the-gut-bacteriome-virome-and-mycobiome-in-glucose-metabolism-disorders-are-we-on-the-right-track
#15
REVIEW
Charikleia Stefanaki, Melpomeni Peppa, George Mastorakos, George P Chrousos
Human gut microbiome is defined as the gene complement of the gut microbial community, measured via laboratory metagenomic techniques. It includes bacteriome, virome and mycobiome, which represent, respectively, the assemblages of bacteria, viruses and fungi, living in the human gut. Gut microbiota function as a living "organ" that interacts with the gastro-intestinal environment, provides nutrients and vitamins to the organism and transduces hormonal messages, essentially influencing the main metabolic pathways, including drug metabolism...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732570/incident-type-2-diabetes-is-associated-with-hdl-but-not-with-its-anti-oxidant-constituent-paraoxonase-1-the-prospective-cohort-prevend-study
#16
Setor K Kunutsor, Lyanne M Kieneker, Stephan J L Bakker, Richard W James, Robin P F Dullaart
OBJECTIVE: High-density lipoprotein cholesterol (HDL-C) is an established risk marker for cardiovascular disease and consistently associated with type 2 diabetes risk. Serum paraoxonase-1 (PON-1) - an anti-oxidant constituent of HDL - is inversely associated with cardiovascular disease risk, but its relationship with incident type 2 diabetes is uncertain. We aimed to investigate the prospective association between PON-1 and type 2 diabetes risk. METHODS: PON-1 was measured as its arylesterase activity at baseline in the Prevention of Renal and Vascular End-stage Disease (PREVEND) prospective study of 5947 predominantly Caucasian participants aged 28-75years with no pre-existing diabetes, that recorded 500 type 2 diabetes cases during a median follow-up of 11...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732569/high-insulin-like-growth-factor-binding-protein-1-igfbp-1-is-associated-with-low-relative-muscle-mass-in-older-women
#17
Frej Stilling, Sara Wallenius, Karl Michaëlsson, Christine Dalgård, Kerstin Brismar, Alicja Wolk
OBJECTIVE: Skeletal muscles serve several important roles in maintaining good health. Insulin-like growth factor-1 (IGF-1) is a promoter of protein synthesis in skeletal muscle. Its binding protein, Insulin-like growth factor-binding protein-1 (IGFBP-1) can be one determinant of IGF-1 activity. In the present study we investigate the association between serum IGFBP-1 and muscle mass. DESIGN: Cross-sectional analysis of 4908 women, between 55 and 85years old, participating in the Swedish Mammography Cohort-Clinical...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732568/effects-of-oral-contraceptives-on-metabolic-profile-in-women-with-polycystic-ovary-syndrome-a-meta-analysis-comparing-products-containing-cyproterone-acetate-with-third-generation-progestins
#18
REVIEW
Mina Amiri, Fahimeh Ramezani Tehrani, Fatemeh Nahidi, Ali Kabir, Fereidoun Azizi, Enrico Carmina
BACKGROUND: Although oral contraceptives (OCs) are the most common treatment in women with polycystic ovary syndrome (PCOS), their effects and safety on the metabolic profiles of these patients are relatively unknown. In this meta-analysis the effects of the different durations (from 3months to 1year) of OC treatment using cyproterone acetate (CA) or third generation progestins on metabolic profile of patients with PCOS were assessed. MATERIALS AND METHODS: PubMed, Scopus, Google Scholar and ScienceDirect databases (2001-2015) were searched to identify clinical trials investigating the effects of OC containing CA or third generation progestins on metabolic profiles of women with PCOS...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732567/curcumin-3-4-dichloro-phenyl-pyrazole-cdpp-overcomes-curcumin-s-low-bioavailability-inhibits-adipogenesis-and-ameliorates-dyslipidemia-by-activating-reverse-cholesterol-transport
#19
Abhishek Gupta, Vinay Kumar Singh, Durgesh Kumar, Pragya Yadav, Santosh Kumar, Muheeb Beg, Kripa Shankar, Salil Varshney, Sujith Rajan, Ankita Srivastava, Rakhi Choudhary, Vishal M Balaramnavar, Rabi Bhatta, Narender Tadigoppula, Anil Nilkanth Gaikwad
BACKGROUND: Adipocyte dysfunction, obesity and associated metabolic disorders are of prime healthcare concern worldwide. Among available medications, natural products and inspired molecules hold 40% space in clinically prescribed medicines. In queue, this study overcomes the drawback of curcumin's low bioavailability with potent anti-adipogenic and anti-dyslipidemic activity. METHODS: To evaluate the role of CDPP on adipocyte differentiation, 3T3-L1 adipocytes were used as an in-vitro model...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732566/association-of-circulating-irisin-levels-with-metabolic-and-metabolite-profiles-of-korean-adolescents
#20
Han Byul Jang, Hyo-Jin Kim, Jae Heon Kang, Sang Ick Park, Kyung Hee Park, Hye-Ja Lee
CONTEXT: Irisin, a novel exercise-induced myokine, has been suggested to regulate energy metabolism. OBJECTIVE: We studied the relationship between circulating irisin and metabolic and metabolite profiles of Korean adolescents, and investigated the effects of physical activity, obesity, and metabolic syndrome (MetS) on irisin levels. MATERIALS AND METHODS: Data were obtained from the Korean Children-Adolescents Study. Our cross-sectional study included 618 adolescents (370 normal-weight and 248 obese adolescents; 316 boys and 302 girls) aged 12-15years...
August 2017: Metabolism: Clinical and Experimental
journal
journal
23785
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"