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Metabolism: Clinical and Experimental

Xiuli Zhang, Tingwen Guan, Boxuan Yang, Zhihong Chi, Zhan-You Wang, Harvest F Gu
OBJECTIVE: Zinc is intimately involved in testosterone production. Zinc transporter 8 (ZnT8) is found to be localized in insulin secretory granules as a β-cell specific Zn transporter. The effect of ZnT8 and related zinc accumulation in steroidogenesis, however, is still unknown. The present study aimed to explore whether ZnT8 plays a role in the facilitation of zinc accumulation and regulation of testosterone synthesis in testicles. METHODS: Leydig cells were isolated from the testicles of human, CD-1 suckling and ZnT8-KO mice...
September 17, 2018: Metabolism: Clinical and Experimental
Maya Rahme, Laila Al Shaar, Ravinder Singh, Rafic Baddoura, Georges Halaby, Asma Arabi, Robert H Habib, Rose Daher, Darina Bassil, Karim El-Ferkh, Maha Hoteit, Ghada El-Hajj Fuleihan
CONTEXT: Liquid Chromatography Mass Spectroscopy (LC-MS/MS) is the preferred method to measure 25 hydroxyvitamin D (25OHD) levels, but laboratories are increasingly adopting automated platform assays. OBJECTIVE: We assessed the performance of commonly used automated immunoassays, with that of LC-MS/MS, and the National Institute of Standards and Technology (NIST) reference values, to measure 25OHD levels. METHODS/SETTING: We compared serum 25OHD levels obtained from 219 elderly subjects, enrolled in a vitamin D trial, using the Diasorin Liaison platform assay, and the tandem LC-MS/MS method...
September 15, 2018: Metabolism: Clinical and Experimental
Andras Franko, Marketa Kovarova, Susanne Feil, Robert Feil, Robert Wagner, Martin Heni, Alfred Königsrainer, Marc Ruoß, Andreas K Nüssler, Cora Weigert, Hans-Ulrich Häring, Stefan Z Lutz, Andreas Peter
BACKGROUND: The activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrosis, however the role of HSCs is less understood in hepatic insulin resistance. Since in the liver cGMP-dependent protein kinase I (cGKI) was detected in HSC but not in hepatocytes, and cGKI-deficient mice that express cGKI selectively in smooth muscle but not in other cell types (cGKI-SM mice) displayed hepatic insulin resistance, we hypothesized that cGKI modulates HSC activation and insulin sensitivity...
September 6, 2018: Metabolism: Clinical and Experimental
Fuyun Bian, Xiang Ma, Sneha Damal Villivalam, Dongjoo You, Lauren Raquel Choy, Anushka Paladugu, Sarah Fung, Sona Kang
Emerging evidence indicates that epigenetic mechanisms like DNA methylation directly contribute to metabolic regulation. For example, we previously demonstrated that de novo DNA methyltransferase Dnmt3a plays a causal role in the development of adipocyte insulin resistance. Recent studies suggest that DNA demethylation plays an important role in the developmental process of adipocytes. However, little is known about whether DNA demethylase ten-eleven translocation (TET) proteins regulate the metabolic functions of adipocytes...
September 5, 2018: Metabolism: Clinical and Experimental
Eun Roh, Jae Woo Park, Gil Myoung Kang, Chan Hee Lee, Hong Dugu, So Young Gil, Do Kyeong Song, Hyo Jin Kim, Gi Hoon Son, Rina Yu, Min-Seon Kim
BACKGROUND: Nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 is an important regulator of hypothalamic neuronal function. Thus, an adequate hypothalamic NAD content is critical for maintaining normal energy homeostasis. METHODS: We investigated whether NAD supplementation increases hypothalamic NAD levels and affects energy metabolism in mice. Furthermore, we investigated the mechanisms underlying the effects of exogenous NAD on central metabolism upon entering the hypothalamus...
September 1, 2018: Metabolism: Clinical and Experimental
Wilfredo Oliva-Olivera, Said Lhamyani, Leticia Coín-Aragüez, Juan Alcaide Torres, Fernando Cardona, Rajaa El Bekay, Francisco J Tinahones
OBJECTIVE: The expansion capacity of white adipose tissue influences the distribution of fat depots in the body, the visceral accumulation of which is linked to metabolic syndrome, regardless of the degree of obesity of the subjects. Alterations in the adipose tissue-derived mesenchymal stem cells (ASCs) may contribute to the adipose tissue remodeling associated with metabolic syndrome and impact the regional distribution of adipose tissue by generating inherently dysfunctional adipocytes...
August 30, 2018: Metabolism: Clinical and Experimental
Niki Katsiki, Dimitri P Mikhailidis, Christos Mantzoros
No abstract text is available yet for this article.
August 30, 2018: Metabolism: Clinical and Experimental
Pablo Villa-Pérez, Beatriz Merino, Cristina M Fernández-Díaz, Pilar Cidad, Carmen D Lobatón, Alfredo Moreno, Harrison T Muturi, Hilda E Ghadieh, Sonia M Najjar, Malcolm A Leissring, Irene Cózar-Castellano, Germán Perdomo
The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define its role in the etiology of hepatic insulin resistance. METHODS: We generated mice with liver-specific deletion of Ide (L-IDE-KO) and assessed insulin clearance and action. RESULTS: L-IDE-KO mice exhibited higher (~20%) fasting and non-fasting plasma glucose levels, glucose intolerance and insulin resistance...
August 8, 2018: Metabolism: Clinical and Experimental
Nikolaos Perakakis, Alireza Yazdani, George E Karniadakis, Christos Mantzoros
No abstract text is available yet for this article.
August 8, 2018: Metabolism: Clinical and Experimental
Rita Ferreira, Rita Nogueira-Ferreira, Fábio Trindade, Rui Vitorino, Scott K Powers, Daniel Moreira-Gonçalves
Mammals respond to muscular exercise by increasing cardiac output to meet the increased demand for oxygen in the working muscles and it is well-established that regular bouts of exercise results in myocardial remodeling. Depending on exercise type, intensity and duration, these cardiac adaptations lead to changes in the energetic substrates required to sustain cardiac contractility. In contrast to the failing heart, fatty acids are the preferred substrate in the trained heart, though glucose metabolism is also enhanced to support oxidative phosphorylation...
August 2, 2018: Metabolism: Clinical and Experimental
S Leon, I Velasco, M J Vázquez, A Barroso, D Beiroa, V Heras, F Ruiz-Pino, M Manfredi-Lozano, A Romero-Ruiz, M A Sanchez-Garrido, C Dieguez, L Pinilla, J Roa, R Nogueiras, M Tena-Sempere
BACKGROUND: RF-amide-related peptide-3 (RFRP-3), the mammalian ortholog of gonadotropin-inhibiting hormone, operates as inhibitory signal for the reproductive axis. Recently, RFRP-3 has been also suggested to stimulate feeding, and therefore might contribute to the control of body weight and its alterations. Yet, characterization of the metabolic actions of RFRP-3 has been so far superficial and mostly pharmacological. Here, we aim to investigate the physiological roles of RFRP-3 signaling in the control of feeding and metabolic homeostasis using a novel mouse model of genetic ablation of its canonical receptor, NPFF1R...
July 31, 2018: Metabolism: Clinical and Experimental
Maryam Akbari, Vahidreza Ostadmohammadi, Kamran B Lankarani, Reza Tabrizi, Fariba Kolahdooz, Seyed Reza Khatibi, Zatollah Asemi
OBJECTIVE: This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effect of alpha-lipoic acid (ALA) supplementation on glycemic control and lipid profiles among patients with metabolic diseases. METHODS: We searched the following databases till October 2017: MEDLINE, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool...
July 7, 2018: Metabolism: Clinical and Experimental
Christina Dimopoulou, Dimitrios G Goulis, Giovanni Corona, Mario Maggi
BACKGROUND: The complex association between metabolic syndrome (MetS) and male hypogonadism is well established. A number of observational studies show that low testosterone is associated with insulin resistance and an increased risk for diabetes mellitus and MetS in men. AIMS: To elucidate the association between MetS and male hypogonadism, present epidemiological data on the co-existence of the two comorbidities, enlighten the underlying pathophysiology and appraise the effects of testosterone supplementation therapy (TTh) and lifestyle modifications on MetS and body composition in men...
September 2018: Metabolism: Clinical and Experimental
Evangelia Kintiraki, Dimitrios G Goulis
Gestational diabetes mellitus (GDM) is the most common metabolic disease of pregnancy, associated with several perinatal complications. Adequate glycemic control has been proved to decrease risk of GDM-related complications. Several studies have shown the beneficial effect of exercise and medical nutrition treatment on glycemic and weight control in GDM-affected women. Moreover, pharmacological agents, such as insulin and specific oral anti-diabetic agents can be prescribed safely during pregnancy, decreasing maternal blood glucose and, thus, perinatal adverse outcomes...
September 2018: Metabolism: Clinical and Experimental
Stefania Lymperi, Aleksander Giwercman
Despite concerns of the scientific community regarding the adverse effects of human exposure to exogenous man-made chemical substances or mixtures that interfere with normal hormonal balance, the so called "endocrine disruptors (EDs)", their production has been increased during the last few decades. EDs' extensive use has been implicated in the increasing incidence of male reproductive disorders including poor semen quality, testicular malignancies and congenital developmental defects such as hypospadias and cryptorchidism...
September 2018: Metabolism: Clinical and Experimental
Gesthimani Mintziori, Dimitrios G Goulis
Recent findings, that specific G protein-coupled TSH receptors (TSHR) and the nuclear thyroid hormone receptors (THRs) are widely expressed in reproductive tissues, reveal the close links between hypothalamus-pituitary-thyroid and hypothalamus-pituitary-gonadal axes. It has been suggested that thyroid function as well as thyroid autoimmunity (TAI) have an impact on Assisted Reproduction Technology (ART) reproductive outcome. Lately, it became evident that ovarian stimulation (OS) may also have an impact on thyroid function...
September 2018: Metabolism: Clinical and Experimental
Dimitrios G Goulis, Christos S Mantzoros
No abstract text is available yet for this article.
September 2018: Metabolism: Clinical and Experimental
Christos P Tsametis, Andrea M Isidori
The finding of low circulating testosterone level in men is relatively frequent. The symptoms of hypogonadism are very frequent in the aging men. However, the diagnosis of hypogonadism is often neglected and the opportunity to replace low testosterone in older men is highly debated. The aim of this narrative review is to summarize the steps necessary to formulate a proper diagnosis and to guide toward an individualized treatment. While universally recognized the need to treat the young adults with known causes of pituitary or testicular failure, there are controversies on the cost-benefit of treating testosterone deficiency in older men...
September 2018: Metabolism: Clinical and Experimental
Mora Murri, María Insenser, Elena Fernández-Durán, José L San-Millán, Manuel Luque-Ramírez, Héctor F Escobar-Morreale
PURPOSE: Circulating micro-ribonucleic acids (miRNAs) are small noncoding RNA molecules that influence gene transcription. We conducted the present profiling study to characterize the expression of circulating miRNAs in lean and obese patients with polycystic ovary syndrome (PCOS), the most common endocrine and metabolic disorder in premenopausal women. BASIC PROCEDURES: We selected 11 control women, 12 patients with PCOS and 12 men so that they were similar in terms of body mass index...
September 2018: Metabolism: Clinical and Experimental
George A Kanakis, Eberhard Nieschlag
Klinefelter syndrome (KS) is the most frequent chromosome disorder in males (1:650 newborn males), defined by 47,XXY karyotype. The classical phenotype is that of a tall male with relatively long legs, small, firm testes and gynecomastia. Azoospermia and infertility are almost inevitably present, but may be overcome by TESE and ICSI. Nevertheless, a broad spectrum of phenotypes has been described and more than 70% of the actually existing KS men may remain undiagnosed throughout their lifespan. Accordingly, hypogonadism is usually not evident until early adulthood and progresses with ageing...
September 2018: Metabolism: Clinical and Experimental
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