Maki Kanzawa, Hiroki Shichi, Keitaro Kanie, Masaaki Yamamoto, Naoki Yamamoto, Yasutaka Tsujimoto, Hironori Bando, Genzo Iguchi, Shigehisa Kitano, Naoko Inoshita, Shozo Yamada, Wataru Ogawa, Tomoo Itoh, Hidenori Fukuoka
BACKGROUND: Corticotrophs are susceptible to lymphocyte cytotoxicity, as seen in hypophysitis, suggesting that an immunological approach may be a potential strategy for corticotroph-derived tumors. OBJECTIVES: We aimed clarify whether corticotroph tumors that induce hypercortisolemia (ACTHomas) could be targets for immunotherapy. METHODS: Tumor-infiltrating immune cells were immunohistochemically analyzed. ACTHomas (Naïve: ACTHomas without preoperative treatment) were compared with other pituitary tumors, and further divided into three different cortisol-exposed milieus: Naïve, Met (ACTHomas with preoperative metyrapone), and SCA (silent corticotroph adenomas)...
February 10, 2024: Endocrinology