journal
MENU ▼
Read by QxMD icon Read
search

Endocrinology

journal
https://www.readbyqxmd.com/read/28009534/ldb1-regulates-energy-homeostasis-during-diet-induced-obesity
#1
Christine Loyd, Yanping Liu, Teayoun Kim, Cassie Holleman, Jamie Galloway, Maigen Bethea, Benjamin N Ediger, Yawen Tang, Thomas A Swain, Doris A Stoffers, Glenn C Rowe, Martin Young, Chad Steele, Kirk M Habegger, Chad S Hunter
The broadly-expressed transcriptional coregulator, Ldb1, is essential for β-cell development and glucose homeostasis. However, it is unclear whether Ldb1 has metabolic roles beyond the β-cell, especially under metabolic stress. Global Ldb1 deletion results in early embryonic lethality; thus, we utilized global heterozygous Ldb1(+/-) and inducible β-cell-specific Ldb1-deficient (Ldb1(Δβ-cell)) mice. We assessed glucose and insulin tolerance, body composition, feeding, and energy expenditure during high-fat diet exposure...
December 23, 2016: Endocrinology
https://www.readbyqxmd.com/read/28009527/reg2-expression-is-required-for-pancreatic-islet-compensation-in-response-to-aging-and-high-fat-diet-induced-obesity
#2
Qing Li, Bing Li, Xiaoliang Miao, Christopher Ramgattie, Zu-Hua Gao, Jun-Li Liu
Maintaining pancreatic β-cell mass and function is essential for normal insulin production and glucose homeostasis. Regenerating islet-derived 2 (Reg2, Reg II, human orthologue Reg1B) gene is normally expressed in pancreatic acinar cells and significantly induced in responses to diabetes, pancreatitis, high-fat diet and during pancreatic regeneration. In order to evaluate the role of endogenous Reg2 production in normal β-cell function, we characterized Reg2 gene deficient mice normally and when subjected to several pathological challenges...
December 23, 2016: Endocrinology
https://www.readbyqxmd.com/read/28005411/a-mutation-in-the-dmp1-gene-alters-phosphate-responsiveness-in-mice
#3
Shoji Ichikawa, Rita Gerard-O'Riley, Dena Acton, Amie K McQueen, Isabel E Strobel, Phillip C Witcher, Jian Q Feng, Michael J Econs
Mutations in the dentin matrix protein 1 (DMP1) gene cause autosomal recessive hypophosphatemic rickets (ARHR). Hypophosphatemia in ARHR results from increased circulating levels of a phosphaturic hormone, fibroblast growth factor 23 (FGF23). Similarly, elevated FGF23, caused by mutations in the PHEX gene, is responsible for the hypophosphatemia in X-linked hypophosphatemic rickets (XLH). Previously, we demonstrated that a Phex mutation in mice creates a lower set point for extracellular phosphate, where an increment in phosphorus further stimulates Fgf23 production to maintain low serum phosphorus levels...
December 22, 2016: Endocrinology
https://www.readbyqxmd.com/read/28005399/bisphenol-s-bps-alters-maternal-behavior-and-brain-in-mice-exposed-during-pregnancy-lactation-and-their-daughters
#4
Mary C Catanese, Laura N Vandenberg
Estrogenic endocrine disrupting chemicals (EDCs) have been shown to disrupt maternal behavior in rodents. We investigated the effects of an emerging xenoestrogen, bisphenol S (BPS), on maternal behavior and brain in CD-1 mice exposed during pregnancy and lactation (F0 generation) and in female offspring exposed during gestation and perinatal development (F1 generation). We observed different effects in F0 and F1 dams for a number of components of maternal behavior including time on the nest, time spent on nest-building, latency to retrieve pups, and latency to retrieve the entire litter...
December 22, 2016: Endocrinology
https://www.readbyqxmd.com/read/28005395/conditional-ablation-of-progesterone-receptor-membrane-component-2-causes-female-premature-reproductive-senescence
#5
N C Clark, C A Pru, S P Yee, J P Lydon, J J Peluso, J K Pru
The non-classical progesterone receptors, progesterone receptor membrane component (PGRMC) 1 and PGRMC2 have been implicated in regulating cell survival of endometrial and ovarian cells in vitro and are abundantly expressed in these cell types. The objective of this study was to determine if Pgrmc1 and Pgrmc2 are essential for normal female reproduction. To accomplish this objective, Pgrmc1 and/or Pgrmc2 floxed mice (Pgrmc2(fl/fl) and Pgrmc1/2(fl/fl)) were crossed with Pgr-cre mice which resulted in the conditional ablation of Pgrmc1 and/or Pgrmc2 from female reproductive tissues (i...
December 22, 2016: Endocrinology
https://www.readbyqxmd.com/read/28001444/vitamin-d-receptor-expression-in-plasmablastic-lymphoma-and-myeloma-cells-confers-susceptibility-to-vitamin-d
#6
Duncan M Gascoyne, Linden Lyne, Hayley Spearman, Francesca M Buffa, Elizabeth J Soilleux, Alison H Banham
Plasmablastic B-cell malignancies include plasmablastic lymphoma and subsets of multiple myeloma and diffuse large B-cell lymphoma (DLBCL). These diseases can be difficult to diagnose and treat, and lack well-characterised cell line models. Here, immunophenotyping and FOXP1 expression profiling identified plasmablastic characteristics in DLBCL cell lines HLY-1 and SU-DHL-9, associated with CTNNAL1, HPGD, RORα, IGF1 and/or vitamin D receptor (VDR) transcription. We demonstrated VDR protein expression in primary plasmablastic tumour cells, and confirmed in cell lines expression of both VDR and the metabolic enzyme CYP27B1, which catalyses active vitamin D3 production...
December 21, 2016: Endocrinology
https://www.readbyqxmd.com/read/27983870/kisspeptin-in-the-hypothalamus-of-two-rat-models-of-polycystic-ovary-syndrome
#7
Satoko Osuka, Akira Iwase, Tatsuo Nakahara, Mika Kondo, Ai Saito, Bayasula, Tomoko Nakamura, Sachiko Takikawa, Maki Goto, Tomomi Kotani, Fumitaka Kikkawa
Hyperandrogenism, disturbance of the hypothalamus-pituitary-ovary axis followed by elevated serum luteinizing hormone (LH) levels, and insulin resistance are involved in the complicated pathophysiology of polycystic ovary syndrome (PCOS). Kisspeptin is co-expressed with neurokinin B (NKB) in the arcuate nucleus (ARC), the center of the gonadotropin-releasing hormone (GnRH)-pulse generator that is responsible for pulsatile LH secretion. We compared two androgenized rat models of PCOS to evaluate the estrous cycle, hormonal profiles, and expression of kisspeptin and NKB in the ARC...
December 16, 2016: Endocrinology
https://www.readbyqxmd.com/read/27983867/roles-of-rfrp-3-in-the-daily-and-seasonal-regulation-of-reproductive-activity-in-female-syrian-hamsters
#8
Jo B Henningsen, Caroline Ancel, Jens D Mikkelsen, François Gauer, Valérie Simonneaux
In females, reproductive activity relies on proper integration of daily and environmental changes as well as cyclic sex-steroid feedback. This study aimed at investigating the role of the hypothalamic Arg-Phe amide-related peptide (RFRP)-3 in the daily and seasonal control of reproductive activity in female Syrian hamsters, by analyzing the RFRP system and investigating the effects of central administration of RFRP-3 at different reproductive stages. In long day-adapted sexually active female hamsters, the number of c-Fos activated RFRP-ir neurons was reduced in the afternoon of diestrus and proestrus, the latter being correlated with increased kisspeptin activity and the LH surge...
December 16, 2016: Endocrinology
https://www.readbyqxmd.com/read/27983866/minireview-therapeutic-implications-of-epigenetic-signaling-in-breast-cancer
#9
Tae Gyu Oh, Shu-Ching M Wang, George E O Muscat
Breast cancer is a heterogeneous disease and its complexity has hindered the development of efficacious treatments targeting all breast cancer subtypes. Many studies have linked the diversity of breast carcinogenesis and metastasis to aberrant epigenetic signaling and control. Here, we focus on the current state of the discipline and review the major epigenetic enzymes controlling chromatin structure and function in the context of breast cancer, including i) DNA methyltransferases, ii) lysine methyltransferases and demethylases, iii) protein arginine methyltransferases, iv) histone acetyltransferases and deacetylases...
December 16, 2016: Endocrinology
https://www.readbyqxmd.com/read/27977298/the-chemical-chaperone-phenylbutyrate-rescues-mct8-mutations-associated-with-milder-phenotypes-in-patients-with-ahds
#10
Doreen Braun, Ulrich Schweizer
Mutations in the thyroid hormone transporter MCT8 prevent appropriate entry of thyroid hormones into brain cells during development and cause severe mental retardation in affected patients. Current treatment options are thyromimetic compounds that enter the brain independent of MCT8. Some MCT8 deficient patients (e.g. those carrying MCT8(delF501)) are not as severely affected than most others. We have shown that MCT8(delF501) protein has decreased protein stability, but significant residual function once it reaches the plasma membrane...
December 15, 2016: Endocrinology
https://www.readbyqxmd.com/read/27967242/low-dose-dihydrotestosterone-drives-metabolic-dysfunction-via-cytosolic-and-nuclear-hepatic-androgen-receptor-mechanisms
#11
Stanley Andrisse, Shameka Childress, Yaping Ma, Katelyn Billings, Yi Chen, Ping Xue, Ashley Stewart, Momodou L Sonko, Andrew Wolfe, Sheng Wu
Androgen excess in women is associated with metabolic dysfunction (obesity, hyperinsulinemia, insulin resistance, and increased risk of type 2 diabetes (T2D)) and reproductive dysfunction (polycystic ovaries, amenorrhea, dysregulated gonadotropin release, and infertility). We sought to identify the effects of androgen excess on glucose metabolic dysfunction and the specific mechanisms of action by which androgens are inducing pathology. We developed a mouse model that displayed pathophysiological serum androgen levels with normal body mass/composition to ensure that the phenotypes were directly from androgens and not an indirect consequence of obesity...
December 14, 2016: Endocrinology
https://www.readbyqxmd.com/read/27967239/lipid-osteoclastokines-regulate-breast-cancer-bone-metastasis
#12
Jing Y Krzeszinski, Adam G Schwaid, Wing Yin Cheng, Zixue Jin, Zachary R Gallegos, Alan Saghatelian, Yihong Wan
Bone metastasis is a deadly consequence of cancers, in which osteoclast forms a vicious cycle with tumor cell. Bone metastasis attenuation by clinical usage of osteoclast inhibitors and in our osteopetrotic mouse genetic models with β-catenin constitutive activation or PPARγ deficiency, fully support the important role of osteoclast in driving the bone metastatic niche. However, the mechanisms for this "partnership in crime" are underexplored. Here we show that osteoclasts reprogram their lipid secretion to support cancer cells...
December 14, 2016: Endocrinology
https://www.readbyqxmd.com/read/27967238/a-refill-for-the-brain-mineralocorticoid-receptor-the-benefit-of-cortisol-add-on-to-dexamethasone-therapy
#13
Onno C Meijer, E Ronald de Kloet
Some serious medical conditions require life-saving treatment with high doses of synthetic glucocorticoids such as dexamethasone. A substantial number of patients subjected to this treatment develops psychosis, mood disturbance or sleep problems. A recent clinical trial demonstrated that dexamethasone therapy of young patients suffering from acute lymphoblastic leukemia (ALL) caused in about 30% of these patients severe adverse psychological effects and sleep disturbances. These side effects were ameliorated by co-administration of a low dose of the naturally occurring glucocorticoid hormone cortisol...
December 14, 2016: Endocrinology
https://www.readbyqxmd.com/read/27967236/pka-riib-deficiency-induces-brown-fat-like-adipocytes-in-inguinal-wat-and-promotes-energy-expenditure-in-male-fvb-nj-mice
#14
Su Jing, Wei Wu, Shan Huang, Ruidan Xue, Yi Wang, Yun Wan, Lv Zhang, Lang Qin, Qiongyue Zhang, Xiaoming Zhu, Zhaoyun Zhang, Hongying Ye, Xiaohui Wu, Yiming Li
Obesity has become the most common metabolic disorder worldwide. Promoting brown adipose tissue (BAT) and beige adipose tissue formation, hence, a functional increase in energy expenditure may counteract obesity. Mice lacking type II-beta regulatory subunit of cAMP-dependent protein kinase A (PKA-RIIB) display reduced adiposity and resistance to diet-induced obesity (DIO). PKA-RIIB, encoded by the Prkar2b gene, is most abundant in BAT and white adipose tissue (WAT) and the brain. In this study, we show that mice lacking PKA-RIIB have increased energy expenditure, limited weight gain, and improved glucose metabolism...
December 14, 2016: Endocrinology
https://www.readbyqxmd.com/read/27967235/17%C3%AE-hsd-type-12-like-is-responsible-for-maturation-inducing-hormone-synthesis-during-oocyte-maturation-in-masu-salmon
#15
Shigeho Ijiri, Yasushi Shibata, Nonoha Takezawa, Yukinori Kazeto, Naoki Takatsuka, Erika Kato, Seishi Hagihara, Yuichi Ozaki, Shinji Adachi, Kohei Yamauchi, Yoshitaka Nagahama
The maturation-inducing hormone 17α,20β-dihydroxy-4-pregnen-3-one (DHP) was first identified in the amago salmon. However, although carbonyl reductase-like 20β-hydroxysteroid dehydrogenase (CR/20β-HSD) was reported to convert 17α-hydroxyprogesterone (17OHP) to DHP in rainbow trout, we previously found that CR/20β-HSD mRNA was not up-regulated in stimulated granulosa cells from masu salmon, which suggested that DHP is synthesized by a different enzyme. Accordingly, the present study aimed to identify the specific 20β-hydroxysteroid dehydrogenase (20β-HSD) responsible for DHP production by granulosa cells during final oocyte maturation in masu salmon...
December 14, 2016: Endocrinology
https://www.readbyqxmd.com/read/27967217/diet-polyphenol-curcumin-stimulates-hepatic-fgf21-production-and-restores-its-sensitivity-in-high-fat-diet-fed-male-mice
#16
Kejing Zeng, Lili Tian, Rucha Patel, Weijuan Shao, Zhuolun Song, Ling Liu, Justin Manuel, Xuezhong Ma, Ian McGilvray, Carolyn L Cummins, Jianping Weng, Tianru Jin
We found previously that short-term curcumin gavage stimulated mouse hepatic Fgf21 expression. Here we conducted mechanistic exploration and investigated the potential pathophysiological relevance on this regulation. Fgf21 stimulation was observed at mRNA and protein levels in mice with daily-curcumin gavage for 4 or 8 days; and in primary hepatocytes with curcumin treatment. Using PPARα agonist and antagonist, along with luciferase reporter and chromatin immune-precipitation approaches, we determined that curcumin stimulates Fgf21 transcription in a mechanism involving PPARα activation...
December 14, 2016: Endocrinology
https://www.readbyqxmd.com/read/27967206/silencing-med12-gene-reduces-proliferation-of-human-leiomyoma-cells-mediated-via-wnt-%C3%AE-catenin-signaling-pathway
#17
Ayman Al-Hendy, Archana Laknaur, Michael P Diamond, Nahed Ismail, Thomas G Boyer, Sunil K Halder
Uterine fibroids, or leiomyoma, are the most common benign tumors in women of reproductive age. Herein, the effect of silencing the mediator complex subunit 12 (Med12) gene in human uterine fibroid cells was evaluated. The role of Med12 in the modulation of Wnt/β-catenin and cell-proliferation-associated signaling was evaluated in human uterine fibroid cells. Med12 was silenced in the immortalized human uterine fibroid cell line (HuLM) using a lentivirus-based Med12 gene-specific RNA interference (RNAi) strategy...
December 14, 2016: Endocrinology
https://www.readbyqxmd.com/read/27967205/gestational-hyperandrogenism-in-developmental-programming
#18
C Hakim, V Padmanabhan, A K Vyas
Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. Potential causes of androgen excess in women include: polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity amongst many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. This paper reviews the various phenotypes of hyperandrogenism during pregnancy, its origin, pathophysiology, and the impact of hyperandrogenism on fetal developmental trajectory and offspring consequences...
December 14, 2016: Endocrinology
https://www.readbyqxmd.com/read/27929669/fgf23-is-not-required-to-regulate-fetal-phosphorus-metabolism-but-exerts-effects-within-12-hours-after-birth
#19
Yue Ma, Beth J Kirby, Nicholas A Fairbridge, Andrew C Karaplis, Beate Lanske, Christopher S Kovacs
Loss of fibroblast growth factor 23 (FGF23) causes hyperphosphatemia, extraskeletal calcifications, and early mortality; excess FGF23 causes hypophosphatemia with rickets or osteomalacia. However, FGF23 may not be important during fetal development. FGF23 deficiency (Fgf23 null) and FGF23 excess (Phex null) did not alter fetal phosphorus or skeletal parameters. In this study we further tested our hypothesis that FGF23 is not essential for fetal phosphorus regulation but becomes important after birth. Although co-receptor Klotho null adults have extremely high FGF23 concentrations, intact FGF23 was normal in Klotho null fetuses, as were fetal phosphorus and skeletal parameters, and placental and renal expression of FGF23 target genes...
December 8, 2016: Endocrinology
https://www.readbyqxmd.com/read/27929668/cd40-signaling-in-graves-disease-is-mediated-through-canonical-and-non-canonical-thyroidal-nf-%C3%AE%C2%BAb-activation
#20
Hanna J Lee, Angela Lombardi, Mihaela Stefan, Cheuk Wun Li, William B Inabnet, Randall P Owen, Erlinda Concepcion, Yaron Tomer
CD40, a tumor necrosis factor receptor, is a major immune-modulating susceptibility gene for Graves' disease (GD) as well as for a variety of other autoimmune diseases. Its broad association with autoimmunity underscores its paramount role in the development of a normal adaptive immune response, primarily in coordinating effective antigen presentation. The molecular pathways by which CD40 activation in the thyroid induces GD are unknown. In this study, we investigated whether NF-κB, a ubiquitious family of transcription factors, mediates the downstream effects of thyroid-specific CD40 activation...
December 8, 2016: Endocrinology
journal
journal
23776
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"