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Journal of Agricultural and Food Chemistry

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https://www.readbyqxmd.com/read/29164887/pterostilbene-enhances-trail-induced-apoptosis-through-the-induction-of-death-receptors-and-downregulation-of-cell-survival-proteins-in-trail-resistance-triple-negative-breast-cancer-cells
#1
Chao-Ming Hung, Liang-Chih Liu, Chi-Tang Ho, Ying-Chao Lin, Tzong-Der Way
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is nontoxic to normal cells and preferentially cytotoxic to cancer cells. However, recent data suggest that malignant breast cancer cells tend to be resistant to TRAIL. Pterostilbene (PTER), a natural dimethylated analog of resveratrol, is known to have diverse pharmacologic activities, including anticancer properties. In the present study, we investigated whether PTER affects TRAIL-induced apoptosis and its mechanism in TRAIL-resistant triple negative breast cancer (TNBC) cells...
November 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29164883/raspberry-ketone-reduced-lipid-accumulation-in-3t3-l1-cells-and-ovariectomy-induced-obesity-in-wistar-rats-by-regulating-autophagy-mechanisms
#2
Sy-Ying Leu, Yi-Chen Chen, Yung-Chieh Tsai, Yao-Wen Hung, Chih-Hsiung Hsu, Yen-Mei Lee, Pao-Yun Cheng
This study aimed to determine the anti-obesity effects of raspberry ketone (RK), one of the major aromatic compounds contained in raspberry, and its underlying mechanisms. During adipogenesis of 3T3-L1 cells, RK (300 μM) significantly reduced lipid accumulation and downregulated the expression of CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferation-activated receptor γ (PPARγ), fatty acid-binding protein 4 (FABP4), and fatty acid synthase (FAS). RK also reduced the expression of light chain 3B (LC3B), autophagy-related protein 12 (Atg12), sirtuin 1 (SIRT1), and phosphorylated-tuberous sclerosis complex 2 (TSC2), whereas it increased the level of p62 and phosphorylated-mammalian target of rapamycin (mTOR)...
November 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29161816/a-rapid-and-efficient-desulfonation-method-for-the-analysis-of-glucosinolates-by-high-resolution-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#3
Jashbir Singh, Guddadarangavvanahal Jayaprakasha, Bhimanagouda S Patil
The goal of our present research was to develop a simple and rapid method for the quantitation of desulfoglucosinolates (desulfoGLS) without using column chromatography. The proposed method involves extraction, concentration, incubation of glucosinolates with sulfatase enzyme, and HPLC analysis. Identification of desulfoGLS in green kohlrabi was performed by LC-HR-ESI-QTOF-MS in positive ionization mode. A total 11 desulfoGLS were identified with neoglucobrassicin (3.32±0.05 µmol/g DW) as the predominant indolyl, whereas progoitrin and sinigrin were the major aliphatic desulfoGLS...
November 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29161812/acute-amino-acid-d-serine-administration-similar-to-ketamine-produces-antidepressant-like-effects-through-the-identical-mechanisms
#4
I-Hua Wei, Kuang-Ti Chen, Mang-Hung Tsai, Ching-Hsiang Wu, Hsien-Yuan Lane, Chih-Chia Huang
D-serine is an amino acid and can work as an agonist at the glycine sites of N-methyl-D-aspartate receptor (NMDAR). Interestingly, both types of glutamatergic modulators, NMDAR enhancers and blockers, can improve depression through common targets, namely alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionaic acid receptors (AMPARs) and mammalian target of rapamycin (mTOR). To elucidate the cellular signaling pathway underlying this counterintuitive observation, we activated NMDARs in rats by using D-serine. Saline, ketamine (NMDAR antagonist), and desipramine (tricyclic antidepressant) were used as controls...
November 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29125749/lc-ms-ms-identification-of-species-specific-muscle-peptides-in-processed-animal-proteins
#5
Daniela Marchis, Alessandra Altomare, Marilena Gili, Federica Ostorero, Amina Khadjavi, Cristiano Corona, Giuseppe Ru, Benedetta Cappelletti, Silvia Gianelli, Francesca Amadeo, Cristiano Rumio, Marina Carini, Giancarlo Aldini, Cristina Casalone
An innovative analytical strategy has been applied to identify signature peptides able to distinguish among processed animal proteins (PAPs) derived from bovine, pig, fish, and milk products. Proteomics was first used to elucidate the proteome of each source. Starting from the identified proteins and using a funnel based approach, a set of abundant and well characterized peptides with suitable physical-chemical properties (signature peptides) and specific for each source was selected. An on-target LC-ESI-MS/MS method (MRM mode) was set up using standard peptides and was then applied to selectively identify the PAP source and also to distinguish proteins from bovine carcass and milk proteins...
November 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29108412/allium-discoloration-color-compounds-formed-during-greening-of-processed-garlic
#6
Roman Kubec, Petr Curko, Petra Urajová, Josep Rubert, Jana Hajšlová
Structures and formation pathways of compounds responsible for blue-green discoloration of processed garlic were studied in model systems. A procedure was developed for isolation of the color compounds and their tentative identification by high-performance liquid chromatography coupled to a diode array detector and tandem mass spectrometry. It was found that the pigment is a mixture of numerous pyrrole-based purple/blue and yellow species. Experiments with isotope-labeled precursors revealed that two molecules of an amino acid are involved in the formation of each color compound...
November 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29161815/bioactive-compounds-of-edible-purple-laver-porphyra-sp-nori
#7
Tomohiro Bito, Fei Teng, Fumio Watanabe
Porphyra sp. (nori) is widely cultivated as an important marine crop. Dried nori contains numerous nutrients including vitamin B12, which is the only vitamin absent from plant-derived food sources. Vegetarian diets are relatively low in iron and vitamin B12; depletion of both causes severe anemia. Nori also contains considerable amounts of iron compared with other plant-derived foods and eicosapentaenoic acid, which is an important fatty acid found in fish oils. In nori, there are also many bioactive compounds exhibiting various pharmacological activities, such as immunomodulation, anticancer, antihyperlipidemic, and antioxidative activities...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29161814/changes-in-aromatic-profile-sugars-and-bioactive-compounds-when-purple-garlic-is-transformed-into-black-garlic
#8
Lucia Martinez-Casas, Maria Lage-Yusty, Julia Lopez-Hernandez
Black garlic is a processed garlic product obtained from the treatment of fresh garlic (Allium sativum L.) under high temperature and high humidity conditions, which leads to modifications in colour, taste and texture. To clarify the physicochemical changes that occur during the thermal process, this study aimed to evaluate and compare the antioxidant activity and other compounds between purple garlic ecotype "Purple from Las Pedroñeras", and its black garlic derivative. Our results showed numerous differences between both, since black garlic presented a significant divergence in the volatile profile, a decreased amount of ascorbic acid, an increment in sugar and polyphenol contents, a greater antioxidant capacity and a different composition of phenolic acids and flavonoids...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29161813/function-analysis-of-an-udp-glycosyltransferase-involved-in-the-biosynthesis-of-polyphenolic-glucoside-in-tea-camellia-sinensis
#9
Xuecheng Zhao, Xinlong Dai, Liping Gao, Lina Guo, Juhua Zhuang, YaJun Liu, Xiubing Ma, Rui Wang, Tao Xia, Yunsheng Wang
Polyphenols are one of the largest groups of compounds that confer benefits to the health of plants and humans. Flavonol glycosides are a major ingredient of polyphenols in Camellia Sinensis. Flavonol 3-O-glycosides are characteristic astringent taste compounds in tea infusion. A polyphenolic glycosyltransferase (CsUGT72AM1) belonging to cluster III b was isolated from the tea plant. The full-length cDNA of CsUGT72AM1 is 1416 bp. It encodes 472 amino acids with a calculated molecular mass of 50.92 kDa and an isoelectric point of 5...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29160704/nanobiotechnology-for-environment-innovative-solutions-for-the-management-of-harmful-algal-blooms
#10
Matthew Robert Gellert, Beum Jun Kim, Samuel Evan Reffsin, Sebastian Eureko Jusuf, Nicole Denise Wagner, Stephen Winans, Mingming Wu
Nanobiotechnology has played important roles in solving contemporary health problems including cancer and diabetes, but has not yet been widely exploited for problems in food security and environmental protection. Water scarcity is an emerging worldwide problem due to climate change and population increase. Current methods of managing water resources are not efficient or sustainable. In this perspective, we focus on harmful algal blooms to demonstrate how nanobiotechnology can be explored to understand microbe-environment interaction and allow for toxin/pollutant detection with significantly improved sensitivity...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29160698/functional-characterization-of-salicylic-acid-carboxyl-methyltransferase-from-camellia-sinensis-providing-the-aroma-compound-of-methyl-salicylate-during-withering-process-of-white-tea
#11
Wei-Wei Deng, Rongxiu Wang, Tianyuan Yang, Li'na Jiang, Zhengzhu Zhang
Methyl salicylate (MeSA) is one of the volatile organic compounds (VOCs) that releases floral scent, and plays an important role in tea sweet flowery aroma. During the withering process for white tea producing, MeSA was generated by salicylic acid carboxyl methyltransferase (SAMT) with salicylic acid (SA), and the specific floral scent was formed. In this study, we firstly cloned a CsSAMT from tea leaves (GenBank accession No. MG459470) and used Escherichia coli and Saccharomyces cerevisiae to express the recombinant CsSAMT...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29156122/preparation-of-lignin-sds-composite-nanoparticles-and-its-application-in-pickering-emulsion-template-based-microencapsulation
#12
Yuxia Pang, Shengwen Wang, Xueqing Qiu, Yanling Luo, Hongming Lou, Jinhao Huang
Lignin is a vastly underutilized biomass resource. The preparation of water dispersed lignin nanoparticles is an effective way to realize the high-value utilization of lignin. However, the currently reported preparation methods of lignin nanoparticles still have some drawbacks, such as the requirement for toxic organic solvent or chemical modification, complicated operation process and poor dispersibility. Here, lignin/SDS composite nanoparticles (LSNPs) with outstanding water dispersibility and a size range of 70-200 nm were facilely prepared via acidifying the mixed basic solution of alkaline lignin and sodium dodecyl sulfate (SDS)...
November 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29155582/improved-chemical-stability-and-antiproliferative-activities-of-curcumin-loaded-nanoparticles-with-chitosan-chlorogenic-acid-conjugate
#13
Yuting Fan, Jiang Yi, Yuzhu Zhang, Wallace Yokoyama
Chitosan (CS)-chlorogenic acid (CA) conjugates were successfully prepared through a free radical-induced grafting method with a substitution of CA on CS of 103.5 mg/g. FT-IR and 1H NMR results confirmed the covalent conjugation of CA onto CS. XRD results indicated the decrease of crystallinity after CA conjugation. DPPH scavenging activity and reducing power studies indicated that CS-CA conjugates had stronger antioxidant activity than chitosan. The particle diameters of curcumin-loaded CS and CS-CA nanoparticles simultaneously formed by ionic gelling in the presence of tripolyphosphate (TPP) were less than 300 nm (243...
November 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29155570/chemistry-antimicrobial-mechanisms-and-antibiotic-activities-of-cinnamaldehyde-against-pathogenic-bacteria-in-animal-feeds-and-human-foods
#14
Mendel Friedman
Cinnamaldehyde is a major constituent of cinnamon essential oils produced by aromatic cinnamon plants. This compound has been reported to exhibit antimicrobial properties in vitro in laboratory media and in animal feeds and human foods contaminated with disease-causing bacteria including Bacillus cereus, Campylobacter jejuni, Clostridium perfringens, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. This integrated review surveys and interprets our current knowledge of the chemistry, analysis, safety, mechanism of action, and antibiotic activities of cinnamaldehyde in food animal (cattle, lambs, calves, pigs, poultry) diets and in widely consumed liquid (apple, carrot, tomato, and watermelon juices, milk) and solid foods...
November 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29129054/the-mulberry-morus-alba-l-fruit-a-review-of-characteristic-components-and-health-benefits
#15
Qingxia Yuan, Longyan Zhao
Mulberry (Morus alba L.) fruit has a high yield in one fruiting season in many countries, especially in Asia, and a long history of use as an edible fruit and traditional medicine. A great diversity of nutritive compounds such as fatty acids, amino acids, vitamins, minerals, and bioactive compounds, including anthocyanins, rutin, quercetin, chlorogenic acid, and polysaccharides have been found in mulberry fruit depending on the cultivars and maturity stages. Furthermore, the extracts and active components of mulberry fruit have demonstrated numerous biological activities, including antioxidant, neuroprotective, antiatherosclerosis, immunomodulative, antitumor, antihyperglycemic, and hypolipidemic activities in in vitro and in vivo studies, and they have received increasing interest from researchers and pharmaceutical companies...
November 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29115836/ros%C3%A3-wine-fining-using-polyvinylpolypyrrolidone-colorimetry-targeted-polyphenomics-and-molecular-dynamics-simulations
#16
Mélodie Gil, Fabian Avila-Salas, Leonardo S Santos, Nerea Iturmendi, Virginie Moine, Véronique Cheynier, Cédric Saucier
Polyvinylpolypyrrolidone (PVPP) is a fining agent polymer used in winemaking to adjust rosé wine color and to prevent organoleptic degradations by reducing polyphenol content. The impact of this polymer on color parameters and polyphenols of rosé wines was investigated, and the binding specificity of polyphenols toward PVPP was determined. Color measured by colorimetry decreased after treatment, thus confirming the adsorption of anthocyanins and other pigments. Phenolic composition was determined before and after fining by targeted polyphenomics (Ultra Performance Liquid Chromatography (UPLC)-Electrospray Ionization(ESI)-Mass Spectrometry (MS/MS))...
November 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29151354/the-discovery-of-a-new-fungicide-candidate-through-lead-optimization-of-pyrimidinamine-derivatives-and-their-activity-against-cucumber-downy-mildew
#17
Aiying Guan, Mingan Wang, Jinlong Yang, Lizeng Wang, Yong Xie, Jie Lan, Changling Liu
Downy mildew is one of the most highly destructive diseases which cause damage to fruits and vegetables. Due to the continual development of resistance, it is important to discover new fungicides with different modes of action from existing fungicides for the control of downy mildew. This study is a continuation of our previous work on the novel pyrimidinamine lead compound 9, followed by field trials to identify the optimal candidate. A new compound, 1c, was obtained which gave a lower EC50 value (0.10 mg/L) against downy mildew than lead compound 9 (0...
November 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29151343/deuterium-labelling-studies-reveal-the-mechanism-of-cytochrome-p450-catalyzed-formation-of-2-aminoacetophenone-from-3-methyl-indole-skatole-in-porcine-liver-microsomes
#18
Christoph Gerlach, Matthias Wuest
2-Aminoacetophenone, a product of the hepatic 3-methylindole (skatole) clearance in pigs, contributes to the specific aroma of fat from tainted boar meat. Surprisingly, high formation rates for 2-aminoacetophenone from 3-methylindole in microsomal preparations from Pietrain × Baden-Württemberg hybrid type boars have been previously demonstrated but the mechanism of this cytochrome P450-mediated reaction remained unknown. Therefore, microsomal fractions from boars were incubated with deuterium labelled skatole and with possible reaction intermediates...
November 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29148756/inhibitory-activities-of-compounds-from-the-marine-actinomycete-williamsia-sp-mccc-1a11233-variant-on-ige-mediated-mast-cells-and-passive-cutaneous-anaphylaxis
#19
Yuanyuan Gao, Qingmei Liu, Bo Liu, Chun-Lan Xie, Min-Jie Cao, Xian-Wen Yang, Guang-Ming Liu
Compounds of the deep-sea-derived marine Williamsia sp. MCCC 1A11233 (CDMW), which are secondary metabolites of the actinomycetes, were isolated. In this study, seven kinds of CDMW were found to decrease degranulation and histamine release in immunoglobulin E (IgE)-mediated rat basophilic leukemia (RBL)-2H3 cells. The production of cytokines (tumor necrosis factor-α and interleukin-4) was inhibited by these CDMW in RBL-2H3 cells, and their chemical structures were established mainly based on detailed analysis of their NMR spectra...
November 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29148742/identification-of-the-peptide-pyroq-%C3%AE-casein194-209-as-a-highly-specific-and-sensitive-marker-to-differentiate-between-ultrahigh-temperature-processed-uht-milk-and-mildly-heated-milk
#20
Sevim Dalabasmaz, Jennifer Ebner, Monika Pischetsrieder
In this study, a new approach was introduced to identify marker peptides that reflect the thermal treatment of commercial milk samples and differentiate ultrahigh-temperature processed (UHT) milk from mildly heated milk. Peptide profiles of training set samples, pasteurized (n=20), extended shelf life (n=29), and UHT (n=29) milk, were recorded by MALDI-TOF-MS after StageTip micro-extraction. As marker candidates, 13 peptides were selected and their cutoff levels were defined. The quality of the cutoff levels was then tested with a blind test set...
November 17, 2017: Journal of Agricultural and Food Chemistry
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