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Indian Journal of Physiology and Pharmacology

Krunal Dalal, Alpa Gor, Barna Ganguly
No abstract text is available yet for this article.
April 2016: Indian Journal of Physiology and Pharmacology
Amita M Pardeshi, Sunanda N Kirtikar
Hypertension is recognized as a key risk factor for cardiovascular disease mortality and morbidity. Early detection of prehypertensive stage may help an individual to lead a healthy life by altering the life style. The present study was attempted to compare blood pressure response and anthropometric parameter in children of hypertensive and non hypertensive parents. The study was conducted on total 120 participants, 60 in control and 60 in test group. Cardiovascular response to stress was determined by Harvard step test...
April 2016: Indian Journal of Physiology and Pharmacology
Snekalatha S
The effect of vitamin C on T lymphocyte function is not clear. In-vivo supplementation of vitamin C is found to have a stimulatory effect on T cells while studies in which ascorbic acid was added to T cell cultures show an inhibition of cell function. The study aims to investigate the effect of ascorbic acid on interleukin-2 secretion by T cells in whole blood cultures which better resembles the physiological environment than pure T cell cultures. It was found that ascorbic acid, when added to whole blood cultures at a very high concentration of 1 mM, inhibits interleukin-2 secretion by T cells (p<0...
April 2016: Indian Journal of Physiology and Pharmacology
Nishanth Sampath, Akanksha Singh, Shridhar Gopalakrishnan, Anu Thukral, M Jeeva Sankar, Ramesh Agarwal, Ashok Kumar Jaryal, Ashok Deorari, Vinod K Paul
Study background: Measurement of delivered pharyngeal pressure during continuous positive airway pressure (CPAP) therapy is not in routine practice due to lack of a simple and affordable technique of intrapharyngeal pressure measurement. To overcome the lack of the gold standard solid-state catheter-tip pressure measurement technology in our set up, we improvised a novel method of pressure measurement and tested its validity in a simulated pharynx. METHODS: A low-cost pressure transducer was improvised by attaching an orogastric tube to its one end...
April 2016: Indian Journal of Physiology and Pharmacology
Meghaa S Bhargava, Harmeet Singh Rehan, Dinesh Kataria
In schizophrenia, efficacy of antipsychotic therapy might be better measured by quality of life (QoL) of caregiver, due to less reliability of patient's account and greater burden of management on caregiver. Hence, we compared QoL of the primary caregiver of schizophrenics prescribed either olanzapine or risperidone. In a cross sectional analytical study, caregivers of 120 schizophrenic patients' on either olanzapine or risperidone filled the WHOQOL-BREF questionnaire containing physical, psychological, social and environmental domains...
April 2016: Indian Journal of Physiology and Pharmacology
Arumugam Ramamoorthy Vijayakumar, Nihar Ranjan Biswas, Vimla Menon, Rohit Saxena, Warisha Ahmed, Nabanita Halder, Thirumurthy Velpandian
An appropriate model to predict the effect of xenobiotics on the vision perception in neuropsychoharmacological studies is of great importance in drug development and toxicity studies. The present study valuated the effect of CNS stimulant, depressant and therapeutic agents known to have ocular toxicity on ptomotor response (OMR) using goldfish in a newly developed device. A digital light processing aided gyrating poly-chromatic dotted pattern-OMR (Gyro-dot-OMR) analyzer was developed and standardized for this study in our laboratory...
April 2016: Indian Journal of Physiology and Pharmacology
Vikas Maharshi, Harmeet Singh Rehan, Lalit Kumar Gupta, Madhur Yadav
An open label randomized controlled study was conducted to compare the quality of life (QoL) and safety of newly diagnosed stage I hypertensive patients randomized into two groups of 30 receiving either enalapril 5 mg or losartan 50 mg per-oral once daily for three months. QoL was assessed at the baseline and at the end of study using SF-36v2 health care questionnaire. Adverse drug reactions (ADRs) were monitored. Investigations at baseline were compared with those after intervention. Pre & post-intervention QoL transformed scores within each group and change in the same between two groups were analyzed using paired and unpaired t-test respectively...
April 2016: Indian Journal of Physiology and Pharmacology
K V Mitha, Saraswati Yadav, B Ganaraja
Prenatal ethanol exposure causes cognitive impairments in rats. This study was designed to evaluate the effect of Centella Asiatica (CeA) in offspring of alcoholic rats. Pregnant rats in alcoholic group were orally fed with 30% alcohol at a dose of 5 g/kg body weight during their gestation period. Pregnant rats in control group were given water. Offspring from alcoholic group were divided into treated group and untreated group. Offspring in treated group were orally given whole plant aqueous extract of CeA at a dose of 20 ml/kg body weight...
April 2016: Indian Journal of Physiology and Pharmacology
Parul Khare, Ajana Talwar, Anjali Trivedi, Dinu S Chandran, Randeep Guleria, Ashok K Jaryal, K K Deepak
BACKGROUND: Post-occlusive reactive hyperemia (RH) is impaired in Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA). The aim of the present study was to examine systemic vascular response and endothelial function in patients of Overlap Syndrome (OS) of COPD and OSA and also to investigate whether OS has any additional effect on endothelial dysfunction when compared to dysfunction caused by COPD alone. METHODS: 31 COPD patients and 13 healthy controls participated in the study...
April 2016: Indian Journal of Physiology and Pharmacology
O P Singh, I S Gambhir, S K Saraf, S B Deshpande, Gaurav Singh
OBJECTIVES: Altered biomechanics leads to the development of degenerative joint disease. The joint pressure and dynamic loading varies during activities of daily living. The study was undertaken to assess the muscle activation pattern of the medial and lateral knee compartments (tibiofemoral joint) during gait in osteoarthritis subjects without and with knee brace undergoing either exercise therapy or balance therapy. The joint load was assessed by the strain gauge transducer and the weight shift pattern is taken as an indicator for the muscle activation pattern...
April 2016: Indian Journal of Physiology and Pharmacology
Safa Anwar, Majumi M Noohu
The aim of the study was to determine the correlation of percentage body fat (%BF) and muscle mass (MM) with aerobic and anaerobic performance in collegiate soccer players. Forty eight male collegiate soccer players were recruited and all the subjects were measured for % BF and MM using bioelectrical impedance analysis (BIA) followed by anaerobic and aerobic performance. The anaerobic performance was measure using vertical jump test and 30 meter sprint test. Aerobic performance tests were Harvard step test and Cooper 12 min run/walk test...
April 2016: Indian Journal of Physiology and Pharmacology
Rupali Parlewar, Rubiya Shaikh
The present study is carried out to assess brainstem auditory evoked potentials in patients of COPD and to evaluate effects of COPD on it before any clinical signs and symptoms of auditory impairment appear. This early diagnosis will help in maintaining a better quality of life in patients of COPD. Study includes 100 individuals divided in two groups, study group (n=50) and controls (n=50). Study group consist of COPD patients those had duration of COPD for more than 5 years with stable course of disease. Latency of wave 1, 111, IV, Vwere prolonged in cases compared to controls in right ear and left ear...
April 2016: Indian Journal of Physiology and Pharmacology
Kaustubh P Telang, Pravin S Jadhao, Mrunal S Phatak
BACKGROUND: It is hypothesized that long-term hypertension might be associated with cognitive decline. OBJECTIVES: The present study was aimed at finding out whether persistently elevated blood pressure affects the processing capability of the central nervous system. METHODS: The cognitive functions of 62 male subjects with age ranging from 40 to 60 years forming various groups as normotensives and hypertensives were assessed through Mini-Cog and audio-visual reaction time...
April 2016: Indian Journal of Physiology and Pharmacology
K K Deepak
No abstract text is available yet for this article.
April 2016: Indian Journal of Physiology and Pharmacology
Sabyasachi Sircar
No abstract text is available yet for this article.
October 2015: Indian Journal of Physiology and Pharmacology
Madhuri Taranikanti, Nikhat Yasmeen, Sanghamitra Panda, Ratna Jyothi Meka, Jayalakshmi Behara, Abdul Raoof Omer Siddiqui
UNLABELLED: Hemostatic system is designed to maintain blood in a fluid state yet provide important defenses against bleeding when injury occurs to the vessel. During surgery, patients are exposed to hemostatic stress causing complications of either hypercoagulability or hemorrhage. The goal of the present study was to describe the clotting changes in patients who underwent major surgeries especially procoagulant mechanisms. METHODS: 30 patients belonging to both sexes who were undergoing surgery for various reasons were included in the study...
October 2015: Indian Journal of Physiology and Pharmacology
Rajiv Rastogi, Priti Bendore
BACKGROUND: Cervical spondylosis is a degenerative disease of cervical spine. The conventional management offered in this condition focuses upon pain, muscle relaxation and restoration of movements. This approach however has not been found adequate in many cases. CASE CHARACTERISTICS: This is a case of cervical spondylosis treated with naturopathy and yogic practices in an OP set up. Earlier to this treatment, the patient was on conventional medicine. INTERVENTION: The patient was given naturopathy treatments in form of cold spinal pack followed by other procedures and some yogic practices consisting of asanas, pranayam and relaxation for 30 minutes for a period of one month with an improvement in symptoms...
October 2015: Indian Journal of Physiology and Pharmacology
Kumar Sai Sailesh, J K Mukkadan
The present study was designed to standardize optimal vestibular stimulation and to investigate its impact on anxiety levels in college students. Vestibular stimulation was achieved by swinging on a swing (Back to front direction) and the participants were advised to adjust frequency, duration and intensity, according to comfort. Frequency, intensity and duration were recorded manually. The anxiety status was assessed by using Spielberger state-trait anxiety inventory (STAI) before and after vestibular stimulation...
October 2015: Indian Journal of Physiology and Pharmacology
Kishore K Deepak, Khalid Umran Al-Umran, Mona H AI-Sheikh, B V Dkoli, Abdullah Al-Rubaish
OBJECTIVES: The functionality of distracters in a multiple choice question plays a very important role. We examined the frequency and impact of functioning and non-functioning distracters on psychometric properties of 5-option items in clinical disciplines. METHODS: We analyzed item statistics of 1115 multiple choice questions from 15 summative assessments of undergraduate medical students and classified the items into five groups by their number of non-functioning distracters...
October 2015: Indian Journal of Physiology and Pharmacology
Vani Gupta, Sameeksha Mishra, Sandeep Kumar, Supriya Mishra
The present study was designed to investigate the association between circulating Orexin-A level with metabolic risk factors in North Indian adult women. 342 women were enrolled for the case-control study, 172 women were with metabolic syndrome (mets) and 170 healthy control women were without metabolic syndrome, (womets) according to (NCEP ATP III criteria). Circulating Orexin-A level was determined by enzyme-linked immunosorbent assay. Observations indicated low levels of orexin-A (26.06 ± 6.09 ng/ml) in women with mets and other metabolic risk factors compared to women without metabolic syndrome (36...
October 2015: Indian Journal of Physiology and Pharmacology
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