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JOURNAL ARTICLE
Rajbala Yadav, Ajay Vir Singh, Shweta Kushwaha, Devendra Singh Chauhan
From an initial thought of being used as a cellular garbage bin to a promising target for liquid biopsies, the role of exosomes has drastically evolved in just a few years of their discovery in 1983. Exosomes are naturally secreted nano-sized vesicles, abundant in all types of body fluids and can be isolated intact even from the stored biological samples. Being stable carriers of genetic material (cellular DNA, mRNA and miRNA) and having specific cargo (signature content of originating cells), exosomes play a crucial role in pathogenesis and have been identified as a novel source of biomarkers in a variety of disease conditions...
February 1, 2024: Indian Journal of Medical Research
#22
JOURNAL ARTICLE
Upasana Baskey, Priya Verma, Palash Mondal, Supradip Dutta, Aritra Biswas, Sagnik Bakshi, Raina Das, Sudipta Bhaduri, Dipankar Maji, Shanta Dutta, Provash Chandra Sadhukhan
BACKGROUND OBJECTIVES: West Bengal is a dengue-endemic State in India, with all four dengue serotypes in co-circulation. The present study was conceived to determine the changing trends of circulating dengue virus (DENV) serotypes in five consecutive years (2015-2019) using a geographic information system (GIS) during the dengue season in West Bengal, India. METHODS: Molecular serotyping of dengue NS1 sero-reactive serum samples from individuals with ≤5 days of fever was performed using conventional nested reverse transcriptase-PCR...
February 1, 2024: Indian Journal of Medical Research
#23
JOURNAL ARTICLE
Vikram Jit Singh, Vandana Roy, Shubha Singhal, M K Daga
BACKGROUND OBJECTIVES: Expenditure on healthcare is a major concern in the geriatric age group. The current study was carried out to assess the expenditure patterns on medicines utilized in geriatric inpatients. METHODS: An observational study was conducted on 1000 geriatric inpatients, aged ≥60 yr, admitted to the medicine unit. Data were collected regarding demographic characteristics, prescribed medicines, expenditure incurred on medicines, appropriateness of medicines prescribed and adverse drug reactions (ADRs)...
February 1, 2024: Indian Journal of Medical Research
#24
JOURNAL ARTICLE
Purna Dwivedi, Mukul Sharma, Afzal Ansari, Pushpendra Singh
Leprosy, an ancient disease, continues to be a public health concern as it remains endemic in several countries. After reaching the elimination target (1/10,000) as a public health problem in 2005 in India, around 1.2 lakh cases have been detected every year over the last decade indicating active transmission of leprosy bacillus (Mycobacterium leprae). Single-nucleotide polymorphisms (SNPs), genomic insertions/deletions and variable-number tandem repeats (VNTRs) have been identified as genetic markers for tracking M...
February 1, 2024: Indian Journal of Medical Research
#25
JOURNAL ARTICLE
Karishma George, Supriya Chopra, Karthick Rajamanickam, Kishore Joshi, Jamema Swamidas, Nitin Shetty, Reena Engineer
BACKGROUND OBJECTIVES: There is limited evidence studying the relationship of liver segmental dose and segmental volume changes. The segmental dose thresholds could potentially allow for segmental regeneration after liver stereotactic body radiation therapy (SBRT). Given improved survival in hepatocellular cancer (HCC) and liver metastases and more salvage therapy options, this has become an important clinical question to explore. This study assesses the impact of liver segmental dose on segmental volume changes (gain or loss) after SBRT...
February 1, 2024: Indian Journal of Medical Research
#26
JOURNAL ARTICLE
Ruchika Gupta, Sanjay Gupta
Incidence of cervical cancer and associated mortality are still high in resource-constrained countries due to the lack of infrastructural facilities and trained workforce. Human papillomavirus (HPV)-based screening tests offer a better sensitivity (>90%) for the detection of cervical high-grade lesions. However, these tests usually require an extensive laboratory set-up and trained technical staff. Moreover, the high cost of the currently available and approved HPV tests precludes their use in the cervical cancer screening programmes in resource-limited settings...
January 15, 2024: Indian Journal of Medical Research
#27
JOURNAL ARTICLE
Sonu Goel, C Anjali, Sitanshu Sekhar Kar, Neema Joseph, Rajeev Kumar, Shravan Kumar Medini, Munmee Das
BACKGROUND OBJECTIVES: The Cigarette and Other Tobacco Products Act (COTPA) limits the sale of tobacco products, promotion and advertising and packaging of tobacco products in India. Periodic monitoring of the level of compliance with all sections of COTPA is obligatory to assess the effectiveness of the act. METHODS: This pre-post study aimed to assess the change in the level of compliance with different sections of COTPA in selected States. A total of 3849 and 2176 samples were assessed during the study in November 202 and October 2021, respectively; using the EpiData Software...
January 13, 2024: Indian Journal of Medical Research
#28
JOURNAL ARTICLE
Shilpi Gupta, Prabhat Kumar, Bhudev Chandra Das
No abstract text is available yet for this article.
January 13, 2024: Indian Journal of Medical Research
#29
JOURNAL ARTICLE
Manickam Ponnaiah, Tarun Bhatnagar, Rizwan Suliankachi Abdulkader, Rajalakshmi Elumalai, Janani Surya, Kathiresan Jeyashree, Muthusamy Santhosh Kumar, Ranjithkumar Govindaraju, Jeromie Wesley Vivian Thangaraj, Hari Krishan Aggarwal, Suresh Balan, Tridip Dutta Baruah, Ayan Basu, Yogita Bavaskar, Ajeet Singh Bhadoria, Ashish Bhalla, Pankaj Bhardwaj, Rachana Bhat, Jaya Chakravarty, Gina Maryann Chandy, Bal Kishan Gupta, Rakesh Kakkar, Ali Hasan Faiz Karnam, Sushila Kataria, Janakkumar Khambholja, Dewesh Kumar, Nithin Kumar, Monaliza Lyngdoh, M Selva Meena, Kedar Mehta, M P Sheethal, Subhasis Mukherjee, Anuj Mundra, Arun Murugan, Seetharaman Narayanan, Balamurugan Nathan, Jutika Ojah, Pushpa Patil, Sunita Pawar, A Charles Pon Ruban, R Vadivelu, Rishabh Kumar Rana, S Nagendra Boopathy, S Priya, Saroj Kumar Sahoo, Arti Shah, Mohammad Shameem, Karthikeyan Shanmugam, Sachin K Shivnitwar, Abhishek Singhai, Saurabh Srivastava, Sudheera Sulgante, Arunansu Talukdar, Alka Verma, Rajaat Vohra, Rabbanie Tariq Wani, Bhargavi Bathula, Gayathri Kumari, Divya Saravana Kumar, Aishwariya Narasimhan, N C Krupa, Thirumaran Senguttuvan, Parvathi Surendran, Dharsikaa Tamilmani, Alka Turuk, Gunjan Kumar, Aparna Murkherjee, Rakesh Aggarwal, Manoj Vasant Murhekar
No abstract text is available yet for this article.
January 5, 2024: Indian Journal of Medical Research
#30
JOURNAL ARTICLE
Diksha Walia, Sonu Goel
No abstract text is available yet for this article.
January 5, 2024: Indian Journal of Medical Research
#31
JOURNAL ARTICLE
Narinder K Mehra
No abstract text is available yet for this article.
January 1, 2024: Indian Journal of Medical Research
#32
JOURNAL ARTICLE
G Srimathi, R Revathy, Bhavani Shankara Bagepally, Beena Joshi
BACKGROUND OBJECTIVES: Iron deficiency anaemia (IDA) during pregnancy is treated with oral and parenteral iron. The objective of this review was to compare the clinical effectiveness, safety, pregnancy and neonatal outcomes of intravenous (iv) ferric carboxymaltose (FCM) and iv iron sucrose (IS) in treating IDA in pregnancy. METHODS: The Department of Health Research funded this study. PubMed, Cochrane Library, EMBASE and Scopus were searched to include studies published till November 2022...
January 1, 2024: Indian Journal of Medical Research
#33
JOURNAL ARTICLE
Paluru Vijayachari, S Awaradi, H M Siddaraju, K Nithin, S S Veerendra, U Suresh Babu, M Punnam Chander, C Kartick, M Anwesh, A P Sugunan
BACKGROUND OBJECTIVES: Shompens are one of the two mongoloid tribes of Nicobar district. There is little information about their recent health status since the last survey which was conducted in 1998. Hence, a comprehensive health and nutritional survey was conducted in March 2017 to assess the changes. The survey was carried out by a joint team of various organizations including the ICMR-Regional Medical Research Centre and Tribal Welfare and Health Department both located in Port Blair...
January 1, 2024: Indian Journal of Medical Research
#34
JOURNAL ARTICLE
Vijit Deepani, Itishree Nayak, Manju Rani, N K Taneja, Damodar Sahu, M Vishnu Vardhana Rao, Ravendra Kumar Sharma
BACKGROUND OBJECTIVES: The tribal populations are vulnerable to mental health issues owing to various reasons. However, limited research has been conducted to assess depression and related determinants among tribal adults aged ≥45 yr (45 years and older). The present study aimed to assess the prevalence and sociodemographic and health determinants of depressive symptoms among the scheduled tribe (ST) population aged ≥45 yr in India. METHODS: The present study analyzed the Wave I data of the Longitudinal Ageing Study in India conducted between April 2017 to December 2018...
January 1, 2024: Indian Journal of Medical Research
#35
JOURNAL ARTICLE
Aquinas Edassery, Ajay Kumar Meher, Vanshika Gupta, Rashmi Rodriguez
BACKGROUND OBJECTIVES: Severe malaria is a cause of excess mortality and morbidity in children in malaria-endemic areas where indigenous people live. Currently, available reports are all from secondary or tertiary care hospitals across India and some African countries. The objective of this study was to assess the clinical and epidemiological profiles of children under five years in two primary care health centres located in tribal-dominant Thuamul Rampur Block of Kalahandi district, Odisha...
January 1, 2024: Indian Journal of Medical Research
#36
JOURNAL ARTICLE
R Revathy, Himanshu Chaurasia, Siddesh Shetty, Beena Joshi
BACKGROUND OBJECTIVES: The Prong 2 of 4 prong strategy introduced by the World Health Organization aims at averting unintended pregnancies among people living with HIV (PLHIV). This systematic review aimed to generate evidence on the effectuality of facility-based interventions in improving uptake of modern and dual contraception, for reducing unmet family planning (FP) needs and unintended pregnancies among PLHIV. METHODS: Articles evaluating facility-based interventions to integrate human immunodeficiency virus (HIV) and FP published in English language were included...
December 27, 2023: Indian Journal of Medical Research
#37
JOURNAL ARTICLE
Rajatashuvra Adhikary
No abstract text is available yet for this article.
December 21, 2023: Indian Journal of Medical Research
#38
JOURNAL ARTICLE
Albina Arjuman
No abstract text is available yet for this article.
December 14, 2023: Indian Journal of Medical Research
#39
JOURNAL ARTICLE
Jigisha Chaudhary, Ekta Gupta, Prashant Kumar Singh, Shalini Singh
Links between tobacco use and poor pregnancy outcomes are well established. Despite various tobacco control measures taken by the government, nearly 5-8 per cent of pregnant women consume tobacco in India. Antenatal check-ups are an opportunity to assess and assist women in quitting tobacco during pregnancy. This review highlights the challenges faced in identifying pregnant tobacco users and providing cessation counselling to them in a formal healthcare setup in the Indian context. For this narrative review, open access databases like PubMed and Google Scholar were searched, using the following search terms: challenges, quitting tobacco use, smokeless tobacco, pregnancy and India...
December 12, 2023: Indian Journal of Medical Research
#40
JOURNAL ARTICLE
Mohammad Shahid, Sonal Srivastava, Priti Shukla, Ravi Yadav, Mohammad Sajid, Anuj Kumar, Shalini Singh, Mausumi Bharadwaj
BACKGROUND OBJECTIVES: Smokeless tobacco (SLT) product consumption has profound public health implications for its users. The pH and moisture of SLTs determine the bioavailability of nicotine, the microbial structure dynamics and the amount of microbial conversion of tobacco alkaloids to carcinogenic tobacco-specific nitrosamines. This study aimed to characterize and compare the pH, moisture and alkaloid content of various SLT products. METHODS: Thirty-seven SLT samples including khaini, snus, moist snuff, gul, pan masala, zarda, Mainpuri kapoori and qiwam were collected from the retail market around the National Capital Region in north India and their pH, moisture, nicotine and alkaloid content were measured...
December 12, 2023: Indian Journal of Medical Research
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