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Indian Journal of Medical Research

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https://www.readbyqxmd.com/read/29067990/erratum
#1
(no author information available yet)
[This corrects the article DOI: 10.4103/ijmr.IJMR_409_17.].
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067989/elephantiasis-nostras-verrucosa
#2
Nilay Sengul Samanci, Sule Poturoglu
No abstract text is available yet for this article.
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067988/report-of-diphtheria-cases-surveillance-among-contacts-in-dibrugarh-assam-india
#3
LETTER
Utpala Devi, Pranjal Jyoti Baruah, Prasanta Kumar Borah, Jagadish Mahanta, Prafulla Dutta
No abstract text is available yet for this article.
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067987/toxigenic-clostridium-difficile-isolates-from-clinically-significant-diarrhoea-in-patients-from-a-tertiary-care-centre
#4
Meenakshi Singh, Chetana Vaishnavi, Rakesh Kochhar, Safrun Mahmood
BACKGROUND & OBJECTIVES: Clostridium difficile is the primary cause of hospital-acquired colitis in patients receiving antibiotics. The pathogenicity of the organism is mainly due to the production of toxins. This study was conducted to investigate the presence of toxigenic C. difficile in the faecal samples of hospitalized patients suspected to have C. difficile infection (CDI) and corroborating the findings with their clinical and demographic data. METHODS: Diarrhoeic samples obtained from 1110 hospitalized patients were cultured for C...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067986/modelling-of-cerebral-tuberculosis-in-balb-c-mice-using-clinical-strain-from-patients-with-cns-tuberculosis-infection
#5
Aliabbas A Husain, Umesh Datta Gupta, Pushpa Gupta, Amit R Nayak, Nitin H Chandak, Hatim F Daginawla, Lokendra Singh, Rajpal Singh Kashyap
BACKGROUND & OBJECTIVES: Central nervous system (CNS) infection caused by Mycobacterium tuberculosis (MTB) is the most severe form of extrapulmonary tuberculosis (EPTB) due to a high level of mortality and morbidity. Limited studies are available on CNS-TB animal model development. The present study describes the development of a murine model of CNS-TB using a clinical strain (C3) isolated from the cerebrospinal fluid (CSF) of CNS-TB patients. METHODS: Groups of mice were infected by the intravenous route with MTB C3 strain isolated from the CSF of CNS-TB patients...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067985/point-prevalence-risk-factor-assessment-for-hospital-acquired-infections-in-a-tertiary-care-hospital-in-pune-india
#6
Velu Nair, A K Sahni, Dinesh Sharma, Naveen Grover, S Shankar, A Chakravarty, Seema Patrikar, Kailas Methe, S S Jaiswal, S S Dalal, Anupam Kapur, Rajesh Verma, Jyoti Prakash, Ashutosh Gupta, Anvita Bhansali, Deepak Batura, G Gopal Rao, D P Joshi, B K Chopra
BACKGROUND & OBJECTIVES: Hospital-acquired infections (HAIs) are a major challenge to patient safety and have serious public health implications by changing the quality of life of patients and sometimes causing disability or even death. The true burden of HAI remains unknown, particularly in developing countries. The objective of this study was to estimate point prevalence of HAI and study the associated risk factors in a tertiary care hospital in Pune, India. METHODS: A series of four cross-sectional point prevalence surveys were carried out between March and August 2014...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067984/association-between-intimate-partner-violence-hiv-aids-exploring-the-pathways-in-indian-context
#7
Seema Patrikar, Dashrath Basannar, Vijay Bhatti, Kunal Chatterjee, Ajoy Mahen
BACKGROUND & OBJECTIVES: Violence against women cutting across diverse socio-economic classes is an under-recognized human rights violation in the world. This analysis was undertaken to examine the prevalence along with predictors of intimate partner violence (IPV) and its association with HIV/AIDS and sexually transmitted infections (STIs) in Indian ever-married women. METHODS: The data obtained from 2005 to 2006 third round of National Family Health Survey-3 (NFHS-3) were used in this study...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067983/occurrence-patterns-predictors-of-hypogonadism-in-patients-with-hiv-infection-in-india
#8
Deep Dutta, Lokesh Kumar Sharma, Neera Sharma, Adesh K Gadpayle, Atul Anand, Kumar Gaurav, Ankit Gupta, Yashwanth Poondla, Bindu Kulshreshtha
BACKGROUND & OBJECTIVES: Data on hypogonadism among human immunodeficiency virus (HIV)-infected Indians are not available. This study was aimed to evaluate the occurrence, pattern and predictors of hypogonadism in HIV-infected Indians. METHODS: Consecutive stable HIV-infected patients, 18-70 yr age, without any severe comorbid state, having at least one year follow up data at the antiretroviral therapy clinic, underwent clinical assessment and hormone assays. RESULTS: From initially screened 527 patients, 359 patients (225 males; 134 females), having disease duration of 61...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067982/clinical-significance-of-magnetic-resonance-imaging-findings-in-chronic-low-backache
#9
A K Kohat, Jayantee Kalita, S Ramanivas, Usha K Misra, R V Phadke
BACKGROUND & OBJECTIVES: Magnetic resonance imaging (MRI) is frequently done for the evaluation of chronic low backache (CLBA), however, its significance in Indian patients has not been evaluated. We report here the MRI findings in patients with CLBA and their sensitivity and specificity with clinical evidence of radiculopathy and localized CLBA as well as correlate these with pain severity and disability. METHODS: Seventy two patients with CLBA aged 20-70 yr without trauma, infection, tumour, metastasis and vascular malformation were included in the study...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067981/coping-in-residual-schizophrenia-re-analysis-of-ways-of-coping-checklist
#10
Ruchita Shah, Sandeep Grover, Parmanand Kulhara
BACKGROUND & OBJECTIVES: Persons with schizophrenia use various coping strategies to adapt to distressing symptoms as well as to deal with daily stressors. Efforts have been made to explore alternative frameworks of coping using Ways of Coping Checklist (WCC) in persons with schizophrenia. This study aimed to re-analyze (factor analysis) the revised-WCC in Indian patients with residual schizophrenia. The secondary aim of the study was to evaluate the relationship of new framework of coping with psychopathology, disability and quality of life (QOL)...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067980/comparative-analysis-of-inflammatory-gene-expression-levels-in-metabolic-syndrome-coronary-artery-disease
#11
Jiny Nair, Vijay V Kakkar, Jayashree Shanker
BACKGROUND & OBJECTIVES: Metabolic syndrome (MetS) increases the likelihood of developing coronary artery disease (CAD), and inflammation is involved in the pathogenesis of both these conditions. The present work was conducted to examine the relative expression of 18 key inflammatory genes associated with MetS and incident CAD in a representative group of patients. METHODS: A total of 178 male patients, including 57 with CAD and 121 without CAD, were enrolled in the study...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067979/peripheral-blood-mononuclear-cells-of-patients-with-latent-autoimmune-diabetes-secrete-higher-levels-of-pro-anti-inflammatory-cytokines-compared-to-those-with-type-1-diabetes-mellitus-following-in-vitro-stimulation-with-%C3%AE-cell-autoantigens
#12
Darshan Badal, Rajendra Kumar, Mahinder Paul, Devi Dayal, Anil Bhansali, Sanjay Kumar Bhadada, Rajesh Kumar, Naresh Sachdeva
BACKGROUND & OBJECTIVES: Type-1 diabetes mellitus (T1DM) and latent autoimmune diabetes in adults (LADA) share similar pathological features but differ in age of onset and progression. There is a scarcity of information on differences in CD4+ T-cell responses, particularly, cytokine secretion, between the two forms of autoimmune diabetes. Here proliferative potential and concentration of pro- and anti-inflammatory cytokines secreted by peripheral blood mononuclear cells (PBMCs) of T1DM and LADA patients were compared, after in vitro stimulation with β-cell autoantigens...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067978/association-of-rheumatic-fever-rheumatic-heart-disease-with-plausible-early-late-stage-disease-markers
#13
Subendu Sarkar, Mukul Rastogi, Priyanka Chaudhary, Rajesh Kumar, Priya Arora, Vivek Sagar, Inderpal Singh Sahni, Sunil Shethi, Khemraj Thakur, Sourav Ailawadhi, Devinder Toor, Anuradha Chakraborti
BACKGROUND & OBJECTIVES: Rheumatic fever (RF) and rheumatic heart disease (RHD) are the autoimmune sequelae caused by Group A Streptococcus. RHD still remains a major concern in the developing countries due to its poor diagnosis, lack of vaccines and social awareness among population. This study was aimed to identify the plausible early- and late-stage disease markers associated with RF/RHD. METHODS: A total of 84 patients with confirmed pharyngitis (n=18), RF (n=23) and RHD (n=43) were included in the comparative analysis of different factors involved in host-pathogen interaction during RF/RHD pathogenesis...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067977/genetic-variations-in-the-dravidian-population-of-south-west-coast-of-india-implications-in-designing-case-control-studies
#14
Anitha D'Cunha, Lekha Pandit, Chaithra Malli
BACKGROUND & OBJECTIVES: Indian data have been largely missing from genome-wide databases that provide information on genetic variations in different populations. This hinders association studies for complex disorders in India. This study was aimed to determine whether the complex genetic structure and endogamy among Indians could potentially influence the design of case-control studies for autoimmune disorders in the south Indian population. METHODS: A total of 12 single nucleotide variations (SNVs) related to genes associated with autoimmune disorders were genotyped in 370 healthy individuals belonging to six different caste groups in southern India...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067976/combination-of-interleukin-10-gene-promoter-polymorphisms-with-hla-drb1-15-allele-is-associated-with-multiple-sclerosis
#15
Majid Shahbazi, Javad Sadeghi Allah Abadi, Danial Roshandel, Maryam Koochaki, Hosein Amiri, Rahim Kohansal, Seied Mohammad Baghbanian, Mahdi Zamani
BACKGROUND & OBJECTIVES: Multiple sclerosis (MS) is common in some ethnic groups. Interleukin-10 (IL-10) is a potent anti-inflammatory and immunosuppressive cytokine that may be an important regulator in MS disease pathogenesis. IL-10 promoter includes several single nucleotide polymorphisms and the level of IL-10 expression is related to these polymorphisms. Furthermore, loci within the histocompatibility regions are responsible for susceptibility to MS. The aim of this study was to investigate the association of IL-10 gene promoter polymorphisms and HLA-DRB1*15 allele frequencies with MS susceptibility in an Iranian population...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067975/sudden-unexpected-death-in-epilepsy
#16
REVIEW
Shishir Nagesh Duble, Sanjeev V Thomas
People with epilepsy have increased risk of premature death, and their life expectancy may reduce by 2-10 yr. Population- and hospital-based studies have shown that the excess mortality in epilepsy is not entirely explained by deaths directly attributable to epilepsy such as accidents and drowning during a seizure. It is also significantly contributed by deaths from other causes such as cardiac deaths, deaths due to malignancies and other causes. It had recently been recognized that sudden unexpected deaths in epilepsy (SUDEP) contributed to a small yet important proportion of mortality in epilepsy...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067974/telomere-length-as-a-potential-biomarker-of-coronary-artery-disease
#17
REVIEW
Joyeeta Bhattacharyya, Keichiro Mihara, Deborshi Bhattacharjee, Manjarí Mukherjee
Coronary artery disease (CAD) is a multifactorial disease whose prevalence remains unabated especially in developing countries. Both lifestyle factors and genetic predisposition contribute to this disorder. Though notable achievements have been made in the medical, interventional and surgical management of CAD, the need for its prevention is more important. Among other modalities, this calls for defining evidence-based new biomarkers, which on their own or in combination with other known biomarkers may predict the risk of CAD to enable institution of appropriate preventive strategies...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067973/alzheimer-s-disease-an-alternative-approach
#18
REVIEW
Sadanandavalli Retnaswami Chandra
Alzheimer's disease (AD) is the most common neurodegenerative cortical dementia. It starts with memory loss, spatial disorientation in people above the age of 65 yr with a preference to females. Its incidence is expected to increase threefold by 2050. It affects almost one out of ten persons above the age of 65 years. Majority of patients are sporadic, but a very small percentage is autosomal dominant. The pathomechanisms postulated include amyloid cascade hypothesis according to which mutation in amyloid precursor protein causes Aβ aggregation...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067972/challenges-options-in-dengue-prevention-control-a-perspective-from-the-2015-outbreak
#19
Siddharth Jain, Surendra K Sharma
No abstract text is available yet for this article.
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29067971/designing-genetic-association-studies-for-complex-traits-in-india
#20
Balraj Mittal, Rama Devi Mittal, Surendra Kumar
No abstract text is available yet for this article.
June 2017: Indian Journal of Medical Research
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