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Indian Journal of Medical Research

Maja Prutki, Igor Petrovic
No abstract text is available yet for this article.
August 2017: Indian Journal of Medical Research
D V R Kiran, Anil Kumar Gupta, Bikash Medhi, Rakesh Kapoor, Navin Pandey
No abstract text is available yet for this article.
August 2017: Indian Journal of Medical Research
K N Nishanth, R K Chadda, M Sood, A Biswas, R Lakshmy
The presence of common physical comorbidities, their demographic and clinical correlates and impact on functioning was assessed in 100 patients with schizophrenia. The patients had a mean age of 35.12±10.7 yr with mean duration of illness of 8.3±0.58 years. Seventy per cent were detected to have a comorbid physical condition. Common conditions included hypertension (21%), diabetes mellitus (15%) and anaemia (12%). Increasing age, being female, being married, longer duration of illness and longer duration of treatment were associated with higher risk of having a comorbid physical illness...
August 2017: Indian Journal of Medical Research
Probodh Borah, Steffen Porwollik, Prerak Desai, Prakash Nayak, Partha Pratim Borah, Pui Cheng, Michael McClelland
BACKGROUND & OBJECTIVES: A rapid and simple alternative method is needed to replace the laborious, time-consuming Salmonella serotyping. The objective of the present study was to improve and simplify a previously reported multiplex polymerase chain reaction (PCR)-based method and to create an online server to enable rapid determination of serovars. METHODS: A method of multiplex PCR-based genome typing (MPGT) was standardized using 59 Salmonella isolates of 31 serovars...
August 2017: Indian Journal of Medical Research
Mithu Medhi, Lahari Saikia, Saurav Jyoti Patgiri, Vicky Lahkar, Md Ezaz Hussain, Sanjeeb Kakati
BACKGROUND & OBJECTIVES: Japanese encephalitis (JE) is a major public health problem in India because of high mortality rate and residual neuropsychiatric damage in the survivors. The present study was undertaken to investigate JE positivity amongst patients admitted with acute encephalitis syndrome (AES) in upper Assam districts and different parameters with their changing trends related to it. METHODS: It was a hospital-based prospective cross-sectional study conducted from January 2012 to December 2014...
August 2017: Indian Journal of Medical Research
Neha Chaturvedi, Sri Krishna, Praveen K Bharti, Deepak Gaur, Virander S Chauhan, Neeru Singh
BACKGROUND & OBJECTIVES: Balaghat district in Central India is a highly malarious district where both Plasmodium falciparum and P. vivax are prevalent. In this district, the persistence of malaria was on an increase and not responsive to intervention measures even though there was no drug resistance. This study was undertaken by conducting mass screening to determine the prevalence of malaria among particularly vulnerable tribe of Balaghat, for developing evidence-based intervention measures for malaria control in hard to reach areas...
August 2017: Indian Journal of Medical Research
Gauresh S Somani, Mruniya S Nahire, Aakash D Parikh, Mandar B Mulik, Priya J Ghumatkar, Kirti S Laddha, Sadhana Sathaye
BACKGROUND & OBJECTIVES: Acetylcholinesterase (AChE) inhibitors represent a major class of drugs which provide symptomatic relief and improvement in cognitive function in Alzheimer's disease (AD). In this study, cubebin, a dibenzylbutyrolactone lignan, was isolated from Piper cubeba and investigated for its AChE inhibitory activity in an attempt to explore its potential for memory-enhancing activities in mice. METHODS: Molecular docking of cubebin was carried out followed by in vitro AChE activity...
August 2017: Indian Journal of Medical Research
Varsha Pursani, Sona Kapoor, S M Metkari, Prabha Nair, Deepa Bhartiya
BACKGROUND & OBJECTIVES: Diabetes is a global disease burden. Various stem cell types are being explored to serve as an alternative source of islets. This study was conducted to evaluate the ability of in-house developed human embryonic stem (hES) cells-derived pancreatic progenitors to ameliorate diabetic symptoms in mice. METHODS: Pancreatic progenitors were packed in macro-capsules and transplanted into six male Swiss mice and four mice were taken as controls...
August 2017: Indian Journal of Medical Research
Agnieszka Sliwinska, Jacek Kasznicki, Marcin Kosmalski, Melania Mikolajczyk, Aneta Rogalska, Karolina Przybylowska, Ireneusz Majsterek, Jozef Drzewoski
BACKGROUND & OBJECTIVES: Tumour protein p53 (TP53) is a stress sensitive transcription factor responsible for the control of cell survival and death to prevent from tumour formation. In vitro and animal studies have indicated that TP53 also responds to metabolic changes and influences metabolic pathways. This study was undertaken to determine the serum level of TP53 and its correlations with clinical and biochemical parameters in type 2 diabetes mellitus (T2DM) patients in comparison to non-diabetic control individuals...
August 2017: Indian Journal of Medical Research
Pinar Kaplan Ozer, Ozlem Sahin, Zafer Ozer, Ahmet Kivanc Cengiz, Yunus Durmaz, Ece Kaptanoglu
BACKGROUND & OBJECTIVES: It has been shown that joint damage due to subclinical synovitis progresses despite apparent clinical remission in rheumatoid arthritis (RA). Hence, finding more objective methods to investigate subclinical synovitis has become a current issue. Ultrasonography (US) has been among the most investigated methods. This study was conducted to detect whether there was subclinical inflammation in RA patients in clinical remission by power Doppler ultrasonography (PDUS) and to evaluate the effects of this inflammation on upper extremity function...
August 2017: Indian Journal of Medical Research
Maryam Rastin, Mahmoud Mahmoudi, Maryam Sahebari, Nafiseh Tabasi
BACKGROUND & OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which affects females more than males. Gender affects the manifestations of SLE and men with lupus show more severe symptoms and worse prognosis. This study was aimed to compare clinical and immunological features in female and male lupus patients in Iran. METHODS: Demographic, clinical and laboratory data from 78 women and 20 men with lupus were collected. Autoantibodies (against nRNP, Sm, SSA, SSB, Ro-52, CENP, Jo-1, Scl-70, nucleosome, anti-dsDNA, histone and Rib-p protein) were determined using immunoblotting technique...
August 2017: Indian Journal of Medical Research
Rachna Seth, Amitabh Singh, Sandeep Seth, Savita Sapra
BACKGROUND & OBJECTIVES: With improved survival of childhood cancer patients, the number of long-term cancer survivors is increasing. Some studies have assessed the long-term morbidity after childhood cancer treatment in the developing countries. This study was conducted to assess the spectrum of late effects of cancer treatment in paediatric cancer survivors. METHODS: Evaluation of the first 300 patients who completed five years of follow up in the after treatment completion clinic was done...
August 2017: Indian Journal of Medical Research
Man Mohan Singh, Madhu Gupta, Sandeep Grover
BACKGROUND & OBJECTIVES: Depression among adolescents is a rising problem globally. There is a need to understand the factors associated with depression among adolescents. This study was conducted to ascertain the prevalence of depressive disorders and associated factors among schoolgoing adolescents in government and private schools in Chandigarh, India. METHODS: A cross-sectional study was conducted among 542 randomly selected schoolgoing adolescents (13-18 yr), from eight schools by multistage sampling technique...
August 2017: Indian Journal of Medical Research
Savita Malhotra, Subho Chakrabarti, Ruchita Shah, Minali Sharma, Kanu Priya Sharma, Akanksha Malhotra, Suneet K Upadhyaya, Mushtaq A Margoob, Dar Maqbool, Gopal D Jassal
BACKGROUND & OBJECTIVES: A knowledge-based, logically-linked online telepsychiatric decision support system for diagnosis and treatment of mental disorders was developed and validated. We evaluated diagnostic accuracy and reliability of the application at remote sites when used by non-psychiatrists who underwent a brief training in its use through video-conferencing. METHODS: The study was conducted at a nodal telepsychiatry centre, and three geographically remote peripheral centres...
August 2017: Indian Journal of Medical Research
Shalini Singh, Yatan Pal Singh Balhara
BACKGROUND & OBJECTIVES: Cannabis is a widely used illicit drug and its use is often associated with co-occurring psychiatric disorders. This systematic review was aimed to provide information on the published Indian studies on co-occurring cannabis use disorders and psychiatric disorders. METHODS: An electronic search of available Indian literature using relevant search terms was carried out in May 2015 and 52 articles in English language published from India were included in the current review...
August 2017: Indian Journal of Medical Research
Sureshkumar Kamalakannan, Aashrai S V Gudlavalleti, Venkata S Murthy Gudlavalleti, Shifalika Goenka, Hannah Kuper
BACKGROUND & OBJECTIVES: There has been more than 100 per cent increase in incidence of stroke in low- and middle-income countries including India from 1970-1979 to 2000-2008. Lack of reliable reporting mechanisms, heterogeneity in methodology, study population, and small sample size in existing epidemiological studies, make an accurate estimation of stroke burden in India challenging. We conducted a systematic review of epidemiologic studies on stroke conducted in India to document the magnitude of stroke...
August 2017: Indian Journal of Medical Research
Nirmalya Roy Moulik, Archana Kumar, Suraksha Agrawal
Folate has been studied in relation to many diseases, especially cancer. Although it has been postulated to exert a dual effect on development of cancer, its role remains to be clearly defined. Its effect on cancer is the result of gene-nutrient interaction between the genes in folate metabolic pathway and dietary folate availability; mutations in genes of folate metabolism have been shown to alter individual susceptibility to certain childhood cancers as well as response to cancer chemotherapy. Although mandatory fortification of food items with folate has been initiated in some countries, many countries are yet to adopt this due to concerns about undesired adverse effects of high folate levels on health, especially cancer...
August 2017: Indian Journal of Medical Research
T Jacob John, Valsan Philip Verghese, Govindakarnavar Arunkumar, Nivedita Gupta, Soumya Swaminathan
No abstract text is available yet for this article.
August 2017: Indian Journal of Medical Research
Prabhdeep Kaur, Ravi Mehrotra, Sankaranarayanan Rengaswamy, Tanvir Kaur, Roopa Hariprasad, Sanjay M Mehendale, Preetha Rajaraman, G K Rath, Neerja Bhatla, Suneeta Krishnan, Anjali Nayyar, Soumya Swaminathan
No abstract text is available yet for this article.
August 2017: Indian Journal of Medical Research
Prakash Balkrishna Behere, Himanshu Deepak Mansharamani, Kanika Kumar
No abstract text is available yet for this article.
August 2017: Indian Journal of Medical Research
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