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Indian Journal of Medical Research

Zile Singh Kundu, R C Siwach
No abstract text is available yet for this article.
June 2018: Indian Journal of Medical Research
Pawan Kumar Singh, Shipra Sharma, Manju Ghosh, Shivaram S Shastri, Neerja Gupta, Madhulika Kabra
No abstract text is available yet for this article.
June 2018: Indian Journal of Medical Research
Shihail Jinna, Ujjwala Nitin Gaikwad
Background & objectives: Legionella pneumophila, a ubiquitous aquatic organism is found to be associated with the development of the community as well as hospital-acquired pneumonia. Diagnosing Legionella infection is difficult unless supplemented with, diagnostic laboratory testing and established evidence for its presence in the hospital environment. Hence, the present study was undertaken to screen the hospital water supplies for the presence of L. pneumophila to show its presence in the hospital environment further facilitating early diagnosis and prevention of hospital-acquired legionellosis...
June 2018: Indian Journal of Medical Research
R Sarita, Sarkaraisamy Ponmariappan, Arti Sharma, Dev Vrat Kamboj, A K Jain
Background & objectives: Botulism, a potentially fatal paralytic illness, is caused by the botulinum neurotoxins (BoNTs) secreted by Clostridium botulinum. It is an obligate anaerobic, Gram-positive, spore-forming bacterium. BoNTs are classified into seven serotypes based on the serological properties. Among these seven serotypes, A, B, E and, rarely, F are responsible for human botulism. The present study was undertaken to develop an enzyme-linked immunosorbent assay (ELISA)-based detection system for the detection of BoNT/E...
June 2018: Indian Journal of Medical Research
Tapinder Kaur Grewal, Shahnawaz Majeed, Sadhna Sharma
Background & objectives: Mycobacterium avium causes atypical infection in both immunocompetent and immunocompromised individuals. Conventional chemotherapy for M. avium infection is not efficient due to lengthy course of treatment and drug-associated toxic side effects. The present study was aimed at reducing dosing frequency of antimicrobial regimen consisting of azithromycin (AZM), rifabutin (RBT) and ethambutol (EMB) by encapsulation of drugs in nanoparticles (NPs) in experimental M...
June 2018: Indian Journal of Medical Research
Vineeta Sharma, V G Ramachandran, Narendra Singh Mogha, Mausumi Bharadwaj
Background & objectives: Hepatitis B and hepatitis C virus (HBV and HCV) cause acute and chronic hepatitis, and infections with HBV and HCV are common in HIV-infected patients. The present study was conducted to determine the co-infection of hepatitis B and C virus in stored serum samples of HIV-positive/negative individuals attending an Integrated Counselling and Testing Centre (ICTC) in north India and their association with certain risk factors. Methods: This study included a total of 840 serum samples, of which 440 were from HIV seropositive individuals and 400 were from control individuals seeking voluntary check-up of HIV status at ICTC...
June 2018: Indian Journal of Medical Research
Aritra Biswas, Rushna Firdaus, Kallol Saha, Prosanto Chowdhury, Debyojyoti Bhattacharya, Maitreyee Bhattacharyya, Provash Chandra Sadhukhan
Background & objectives: Multiple transfusions in β-thalassaemia patients undergoing regular transfusion regimen are at a risk of developing transfusion transmitted infections, including hepatitis C virus (HCV). The present study was conducted to investigate the association of HCV viraemia and genotype with clinical parameters in HCV seroreactive β-thalassaemic individuals. Methods: A total of 172 HCV seroreactive β-thalassaemic individuals aged between 2-35 yr with at least 25 units of blood transfusion were catagorized into four groups (2-12 yr, group 1; 13-19 yr, group 2; 20-29 yr, group 3; 30-35 yr, group 4)...
June 2018: Indian Journal of Medical Research
Vijay Kumar Karra, Soumya Jyoti Chowdhury, Rajesh Ruttala, Phani Kumar Gumma, Sunil Kumar Polipalli, Anita Chakravarti, Premashis Kar
Background & objectives: Clinical outcome after hepatitis B virus (HBV) exposure varies extremely from spontaneous clearance to chronic hepatitis B and often progresses to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Host genetic factor plays an important role in the regulation of immune response. This study was aimed to investigate whether HLA class II DQA1 and DQB1 gene polymorphism were associated with chronic hepatitis B infection and in the development of HBV-related LC and HCC...
June 2018: Indian Journal of Medical Research
Neeraj Kumar, Krishan Gauba, Ashima Goyal, Aditi Kapur
Background & objectives: Various indices are available to record different grade of severity of dental fluorosis. These indices have chances of inter- and intra- examiner variability. Therefore, study was conducted to compare three different indices for recording dental fluorosis to find out the best and most practical index of recording dental fluorosis for field studies in children living in a fluoride endemic area. Methods: The severity grades were recorded in 300 schoolchildren aged 12-15 yr having dental fluorosis of low, medium and high fluoride areas using three different indices, viz...
June 2018: Indian Journal of Medical Research
Panneer Devaraju, Sonal Mehra, Reena Gulati, Paul T Antony, Vikramraj K Jain, Durga Prasanna Misra, Vir Singh Negi
Background & objectives: Genetic aberrations disrupting toll-like receptor and interferon homeostasis enhance the risk of systemic lupus erythematosus (SLE). Raised serum interferon-alpha (IFN-α) levels in SLE patients have been ascribed to polymorphism (rs2004640 G/T) in interferon regulatory factor 5 (IRF5) gene, resulting in enhanced transcript splicing. A positive association between IRF5 polymorphism and SLE risk has been reported in many populations. This study was aimed to find out frequency of IRF5 rs2004640 G/T polymorphism in patients with SLE and healthy controls and to assess its influence on susceptibility, clinical and serological characteristics of SLE...
June 2018: Indian Journal of Medical Research
Manisha Sudhir Chaudhari-Kank, Kusum Zaveri, Vistasp Antia, Indira Hinduja
Background & objectives: CD9 and CD146 are important adhesion molecules that play a role in the implantation of an embryo. This study was undertaken to correlate the expression of these markers in fertile and infertile women's endometrial stromal cells. Methods: Human endometrial stromal cell culture from endometrial biopsies of fertile (n=50) and infertile females (n=50) was performed and primary cell lines were established. Expression of CD9 and CD146 was studied for all the 100 cell lines with the help of flow cytometry...
June 2018: Indian Journal of Medical Research
Prateek Sharma, Sanjeev Kumar
Background & objectives: Insulin resistance associated with hyperinsulinaemia and overexpression of insulin receptors (IRs) have been intricately linked to the pathogenesis and treatment outcomes of the breast carcinoma. Studies have revealed that upregulated expression of IRs in breast cancer pathogenesis regulates several aspects of the malignant phenotype, including cell proliferation and metastasis. This study was aimed to investigate the pivotal role of an IR antagonist S961 on IR signalling and other biological parameters in MCF-7, MDA-MB-231 and T47D cell lines...
June 2018: Indian Journal of Medical Research
Dilip Abraham, Saravanakumar Puthupalayam Kaliappan, Judd L Walson, Sitara Swarna Rao Ajjampur
Soil-transmitted helminth (STH) infections continue to be a major global cause of morbidity, with a large proportion of the burden of STH infections occurring in India. In addition to direct health impacts of these infections, including anaemia and nutritional deficiencies in children, these infections also significantly impact economic development, as a result of delays in early childhood cognitive development and future income earning potential. The current World Health Organization strategy for STH is focused on morbidity control through the application of mass drug administration to all pre-school-aged and school-aged children...
June 2018: Indian Journal of Medical Research
Priya Srinivas, Madhavan Radhakrishna Pillai
No abstract text is available yet for this article.
June 2018: Indian Journal of Medical Research
Ugochi O Ogu, Henny H Billett
No abstract text is available yet for this article.
June 2018: Indian Journal of Medical Research
Sonali Bajaj, Kabir Sardana
No abstract text is available yet for this article.
May 2018: Indian Journal of Medical Research
O P Dhakal, Mona Dhakal
No abstract text is available yet for this article.
May 2018: Indian Journal of Medical Research
C K Singh, Ajaz Ahmad
Background & objectives: The ante-mortem diagnosis of rabies is of great significance in establishing the status of infection in dogs, especially since they are involved in exposure to human beings. The present study was, therefore, undertaken to elucidate the most appropriate secretion/tissue for reliable diagnosis of rabies in 26 living dogs suspected to be rabid. Methods: In the present study 26 dogs suspected to have rabies were included for ante-mortem diagnosis of rabies in clinical samples of skin and saliva by molecular approach viz...
May 2018: Indian Journal of Medical Research
Bharti Malhotra, Anu Kanwar, P V Janardhan Reddy, Aradhana Chauhan, Jitendra Tiwari, Shipra Bhargava, H N Verma
Background & objectives: Hepatitis A virus (HAV) infection is a major cause of childhood hepatitis, prevalent worldwide. HAV is classified into seven genotypes I-VII; genotypes III and I are the most common among humans. The present work was carried out to identify the genotypes prevalent in children suspected to have acute viral hepatitis (AVH), hospitalized at a tertiary care centre in northwest India. Methods: A total of 1269 blood samples from children (0-15 yr of age) clinically suspected of viral hepatitis were screened for anti-HAV IgM...
May 2018: Indian Journal of Medical Research
Nishanth Krishna Kodyalamoole, Sanjeev Badiger, Nalam Udaya Kiran, Sunil Kumar Dodderi, B B Rewari
Background & objectives: Karnataka is a high HIV prevalent State in India. Although benefits have been shown by disclosing the HIV status to the child, information regarding HIV status disclosure in Karnataka is limited. Hence, this study was conducted to estimate the proportion of children who had been disclosed of their HIV status and its pattern among those who visited the district antiretroviral therapy (ART) centre in coastal Karnataka. Methods: A cross-sectional study was conducted in an ART centre in a district hospital in coastal Karnataka between October 2014 and July 2015...
May 2018: Indian Journal of Medical Research
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