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Indian Journal of Medical Research

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https://www.readbyqxmd.com/read/27934815/hypopituitarism-following-rifle-cleaning-accident
#1
Vimal Upreti, Narendra Kotwal
No abstract text is available yet for this article.
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934814/giant-cutaneous-horns
#2
Gobinda Chatterjee, Atul Jain
No abstract text is available yet for this article.
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934813/revisiting-tuberculids-five-year-experience-in-a-tertiary-care-teaching-hospital
#3
LETTER
Maitreyee Panda, Nibedita Patro, Bikash Ranjan Kar, Chandra Sekhar Sirka, Bharati Sahu, Mrutunjaya Dash
No abstract text is available yet for this article.
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934812/haitian-variant-tcpa-in-vibrio-cholerae-o1-el-tor-strains-in-national-capital-region-india
#4
LETTER
Dhirendra Kumar, Naresh Chand Sharma, Thandavarayan Ramamurthy, Sushil Kumar Gupta, Devinder Kumar Seth
No abstract text is available yet for this article.
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934811/performance-of-the-2010-american-college-of-rheumatology-european-league-against-rheumatism-acr-eular-criteria-for-classification-of-rheumatoid-arthritis-in-an-indian-population-an-observational-study-in-a-single-centre
#5
Mvv Pavan Kedar, Raviraja V Acharya, K Prakashini
BACKGROUND & OBJECTIVES: The 1987 American College of Rheumatology (ACR) criteria were criticised for classifying patients only in the late stage. The 2010 ACR/European League against Rheumatism (ACR/EULAR) classification criteria for rheumatoid arthritis (RA) were thus formulated to recognize the early stage of disease with high sensitivity. This pilot study was designed to estimate and compare the sensitivities of the 1987 ACR and 2010 ACR/EULAR classification criteria for RA. METHODS: In a tertiary care hospital, the medical records of 97 patients diagnosed with RA were reviewed...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934810/effect-of-hypertension-at-presentation-on-prognosis-in-patients-with-dilated-cardiomyopathy-presenting-with-normal-renal-angiogram
#6
Swetha Balije, Ashutosh Kumar, Goru Bhawani, Kasturi S N Murthy, Neera Kumari
BACKGROUND & OBJECTIVES: Dilated cardiomyopathy (DCM) is a progressive disease of heart with systolic and diastolic dysfunction carrying a poor long-term prognosis. The prognostic index and predictors of mortality are considered to be useful in guiding the treatment. This study was undertaken to evaluate the effects of hypertension at presentation on prognosis in patients with DCM presenting with normal renal and coronary angiogram. METHODS: An observational, analytical, non-interventional and a combination of retrospective and prospective study was conducted in patients between 15 and 75 yr of age with DCM having on and off symptoms while receiving treatment in a cardiology outpatient department for more than a year...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934809/wilms-tumour-1-gene-mutations-in-south-indian-children-with-steroid-resistant-nephrotic-syndrome
#7
Aravind Selvin Kumar, R Srilakshmi, Smk Karthickeyan, K Balakrishnan, R Padmaraj, Prabha Senguttuvan
BACKGROUND & OBJECTIVES: Clinically, nephrotic syndrome (NS) is a diverse group of symptoms; about 20 per cent of NS cases are resistant to steroid treatment, and within ten years they progress to end-stage renal disease. The present study was undertaken to identify the mutations of Wilms' tumour 1 (WT1) gene in steroid-resistant NS (SRNS) children. METHODS: A total of 173 children with SRNS and 100 children in the control group were enrolled in the study. DNA extraction was done, screened for WT1 (exons 8 and 9) gene amplified by polymerase chain reaction and direct sequencing...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934808/presence-of-metallo-beta-lactamases-mbl-extended-spectrum-beta-lactamase-esbl-ampc-positive-non-fermenting-gram-negative-bacilli-among-intensive-care-unit-patients-with-special-reference-to-molecular-detection-of-blactx-m-blaampc-genes
#8
Richa Gupta, Abida Malik, Meher Rizvi, Moied Ahmed
BACKGROUND & OBJECTIVES: Non-fermenting Gram-negative bacilli (NFGNB) including Pseudomonas aeruginosa and Acinetobacter baumannii have been implicated in a variety of infections, particularly in the Intensive Care Units (ICUs). This study was aimed to overview the burden of multidrug-resistant NFGNB causing infections in ICU and also to assess the occurrence of extended-spectrum beta-lactamases (ESBLs), AmpC and metallo-beta-lactamases (MBLs) among these isolates. METHODS: Bacterial culture, identification and antibiotic susceptibility were carried out...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934807/transmission-of-mutans-streptococci-in-mother-child-pairs
#9
S G Damle, Renu Yadav, Shalini Garg, Abhishek Dhindsa, Vikas Beniwal, Ashish Loomba, Shailja Chatterjee
BACKGROUND & OBJECTIVES: Dental caries is an infectious, transmissible disease. Maternal transfer of mutans streptococci (MS) has been a subject of research. The aim of this study was to evaluate the transmission of MS from mother to children through genetic analysis. METHODS: Thirty mother-child pairs were included and divided into three groups according to the age of the children. Saliva samples were collected and MS colonies from each mother-child pair were isolated...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934806/molecular-appraisal-of-intestinal-parasitic-infection-in-transplant-recipients
#10
Pooja Yadav, Shehla Khalil, Bijay Ranjan Mirdha
BACKGROUND & OBJECTIVES: Diarrhoea is the main clinical manifestation caused by intestinal parasitic infections in patients, with special reference to transplant recipients who require careful consideration to reduce morbidity and mortality. Further, molecular characterization of some important parasites is necessary to delineate the different modes of transmission to consider appropriate management strategies. We undertook this study to investigate the intestinal parasitic infections in transplant recipients with or without diarrhoea, and the genotypes of the isolated parasites were also determined...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934805/comparison-of-clinical-effects-of-beclomethasone-dipropionate-budesonide-in-treatment-of-children-with-mild-persistent-asthma-a-double-blind-randomized-controlled-study
#11
Anju Singh, Devki Nandan, Vivek Dewan, Jhuma Sankar
BACKGROUND & OBJECTIVES: Various inhaled corticosteroids (ICSs) are available to control the symptoms of asthma. Although beclomethasone dipropionate (BDP) and budesonide (BUD) are one of the oldest ICSs, their wide availability and low cost make them attractive options in developing countries. Due to lack of consensus on which of the two drugs is better for controlling mild persistent asthma, we undertook this study to compare the efficacy of these two drugs by measuring the change in percentage predicted forced expiratory volume in one second (FEV 1 ) from baseline in children with mild persistent asthma...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934804/use-of-hydrogen-peroxide-vapour-plasma-irradiation-in-combination-for-quick-decontamination-of-closed-chambers
#12
Devendra T Mourya, Hamish C Shahani, Pragya D Yadav, Pradip V Barde
BACKGROUND & OBJECTIVES: Various conventional methods such as gaseous, vapour and misting systems, fogging, manual spray and wipe techniques employing a number of chemical agents are used for decontamination of enclosed spaces. Among all these methods, use of aerosolized formaldehyde is the most preferred method due to cost-effectiveness and practical aspects. However, being extremely corrosive in nature generating very irritating fumes and difficulty in maintaining a high level of gas concentration, many laboratories prefer the vaporization of hydrogen peroxide (H 2 O 2 ) as an alternative...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934803/chronic-vitamin-a-enriched-diet-feeding-regulates-hypercholesterolaemia-through-transcriptional-regulation-of-reverse-cholesterol-transport-pathway-genes-in-obese-rat-model-of-wnin-gr-ob-strain
#13
Shanmugam M Jeyakumar, Alex Sheril, Ayyalasomayajula Vajreswari
BACKGROUND & OBJECTIVES: Hepatic scavenger receptor class B1 (SR-B1), a high-density lipoprotein (HDL) receptor, is involved in the selective uptake of HDL-associated esterified cholesterol (EC), thereby regulates cholesterol homoeostasis and improves reverse cholesterol transport. Previously, we reported in euglycaemic obese rats (WNIN/Ob strain) that feeding of vitamin A-enriched diet normalized hypercholesterolaemia, possibly through hepatic SR-B1-mediated pathway. This study was aimed to test whether it would be possible to normalize hypercholesterolaemia in glucose-intolerant obese rat model (WNIN/GR/Ob) through similar mechanism by feeding identical vitamin A-enriched diet...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934802/circulating-heat-shock-protein-mrna-profile-in-gestational-hypertension-pre-eclampsia-foetal-growth-restriction
#14
Ilona Hromadnikova, Lenka Dvorakova, Katerina Kotlabova, Andrea Kestlerova, Lucie Hympanova, Veronika Novotna, Jindrich Doucha, Ladislav Krofta
BACKGROUND & OBJECTIVES: Heat shock proteins (Hsp) are ubiquitously distributed phylogenetically conserved molecules that regulate cellular homeostasis and maintain the integrity and function of cellular proteins. Increased levels of Hsp in maternal circulation have been shown to be associated with increased risk of pregnancy related complications. The objective of this study was to explore extracellular Hsp mRNA levels in maternal circulation and quantified Hsp27, Hsp60, Hsp70, Hsp90 and Hsp70 binding protein 1 (HspBP1) mRNAs in maternal plasma samples using real-time reverse-transcriptase polymerase chain reaction...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934801/derivation-validation-of-glycosylated-haemoglobin-hba-1c-cut-off-value-as-a-diagnostic-test-for-type-2-diabetes-in-south-indian-population
#15
Alladi Mohan, S Aparna Reddy, Alok Sachan, Kvs Sarma, D Prabath Kumar, Mahesh V Panchagnula, Pvln Srinivasa Rao, B Siddhartha Kumar, P Krishnaprasanthi
BACKGROUND & OBJECTIVES: Glycosylated haemoglobin (HbA 1c ) has been in use for more than a decade, as a diagnostic test for type 2 diabetes. Validity of HbA 1c needs to be established in the ethnic population in which it is intended to be used. The objective of this study was to derive and validate a HbA 1c cut-off value for the diagnosis of type 2 diabetes in the ethnic population of Rayalaseema area of south India. METHODS: In this cross-sectional study, consecutive patients suspected to have type 2 diabetes underwent fasting plasma glucose (FPG) and 2 h post-load plasma glucose (2 h-PG) measurements after a 75 g glucose load and HbA 1c estimation...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934800/effect-of-a-polyherbal-formulation-cream-on-diabetic-neuropathic-pain-among-patients-with-type-2-diabetes-a-pilot-study
#16
Vijay Viswanathan, Seena Rajsekar, Bamila Selvaraj, Satyavani Kumpatla
BACKGROUND & OBJECTIVES: Painful diabetic neuropathy is a common complication of diabetes and can severely limit patients' daily functions. The aim of this pilot study was to evaluate the safety and effect of using a polyherbal formulation in reducing the symptoms of diabetic neuropathic pain in comparison with placebo among patients with type 2 diabetes. METHODS: A total of 50 (M:F = 33:17) consecutive type 2 diabetes patients with painful diabetic neuropathy were enrolled in this study...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934799/subtelomeric-rearrangements-in-indian-children-with-idiopathic-intellectual-disability-developmental-delay-frequency-estimation-clinical-correlation-using-fluorescence-in-situ-hybridization-fish
#17
Shruthi Mohan, Teena Koshy, Perumal Vekatachalam, Sheela Nampoothiri, Dhanya Yesodharan, Kalpana Gowrishankar, Jeevan Kumar, Latha Ravichandran, Santhosh Joseph, Anupama Chandrasekaran, Solomon F D Paul
BACKGROUND & OBJECTIVES: Subtelomeres are prone to deleterious rearrangements owing to their proximity to unique sequences on the one end and telomeric repetitive sequences, which increase their tendency to recombine, on the other end. These subtelomeric rearrangements resulting in segmental aneusomy are reported to contribute to the aetiology of idiopathic intellectual disability/developmental delay (ID/DD). We undertook this study to estimate the frequency of subtelomeric rearrangements in children with ID/DD...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934798/identification-of-a-novel-collagen-type-iv-alpha-4-col4a4-mutation-in-a-chinese-family-with-autosomal-dominant-alport-syndrome-using-exome-sequencing
#18
Sheng Deng, Hongbo Xu, Jinzhong Yuan, Jingjing Xiao, Lamei Yuan, Xiong Deng, Liping Guan, Anding Zhu, Pengfei Rong, Jianguo Zhang, Hao Deng
BACKGROUND & OBJECTIVES: Alport syndrome (AS) is an inherited disorder characterized by glomerulonephritis and end-stage renal disease (ESRD). The aim of this study was to identify the gene responsible for the glomerulopathy in a Chinese family with autosomal dominant AS using exome sequencing. METHODS: A 4-generation, 30-member Chinese Han family was enrolled in this study. Exome sequencing was conducted in the proband of the family, and then direct sequencing was performed in family members of the pedigree and 100 normal controls...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934797/small-for-gestational-age-versus-appropriate-for-gestational-age-comparison-of-cord-blood-lipid-profile-insulin-levels-in-term-newborns-saga-act-study
#19
Limmy Loret Lobo, H Uday Kumar, Tejeswita Mishra, Tripura Sundari, Archana Singh, C Vijai Kumar, G Kondal Rao, B Jahangir, Vijay Misale, Poonam Prashant, Nirlep L Gajiwala, Ashok S Thakkar
BACKGROUND & OBJECTIVES: The genesis of atherosclerotic lesions, a major cardiovascular risk factor starts in the early stage of life. If the premature development of cardiovascular risk factors can be anticipated during childhood, cardiovascular events can be prevented effectively by taking appropriate measures. This study was carried out to assess the role of in utero malnutrition in cardiovascular disease development by comparing cord blood lipid profiles and serum insulin levels between small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) term newborns...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934796/plga-loaded-nanomedicines-in-melanoma-treatment-future-prospect-for-efficient-drug-delivery
#20
REVIEW
Sreemanti Das, Anisur Rahman Khuda-Bukhsh
Current treatment methods for melanoma have some limitations such as less target-specific action, severe side effects and resistance to drugs. Significant progress has been made in exploring novel drug delivery systems based on suitable biochemical mechanisms using nanoparticles ranging from 10 to 400 nm for drug delivery and imaging, utilizing their enhanced penetration and retention properties. Poly-lactide-co-glycolide (PLGA), a copolymer of poly-lactic acid and poly-glycolic acid, provides an ideally suited performance-based design for better penetration into skin cells, thereby having a greater potential for the treatment of melanoma...
August 2016: Indian Journal of Medical Research
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