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Hereditas

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https://www.readbyqxmd.com/read/28974924/regulatory-pathway-analysis-of-coat-color-genes-in-mongolian-horses
#1
Bei Li, Xiaolong He, Yiping Zhao, Dongyi Bai, Wunierfu Shiraigo, Qinan Zhao, Dugarjaviin Manglai
BACKGROUND: Studies on the molecular genetics of horse skin pigmentation have typically focused on very few genes and proteins. In this study, we used Illumina sequencing to determine the global gene expression profiles in horses with white-colored coats and those with black-colored coats, with the goal of identifying novel genes that could regulate horse coat color. RESULTS: Genes encoding ribosomal-associated proteins were highly expressed in horse skin. We found a total of 231 unigenes that were differentially expressed between horses with white coats and horses with black coats; 119 were down-regulated, and 112 were up-regulated...
2018: Hereditas
https://www.readbyqxmd.com/read/28974923/drosophila-exoribonuclease-nibbler-is-a-tumor-suppressor-acts-within-the-rna-i-machinery-and-is-not-enriched-in-the-nuage-during-early-oogenesis
#2
Casimiro Castillejo-López, Xiaoli Cai, Khalid Fahmy, Stefan Baumgartner
BACKGROUND: micro RNAs (miRNAs) are important regulators of many biological pathways. A plethora of steps are required to form, from a precursor, the mature miRNA that eventually acts on its target RNA to repress its expression or to inhibit translation. Recently, Drosophila nibbler (nbr) has been shown to be an important player in the maturation process of miRNA and piRNA. Nbr is an exoribonuclease which helps to shape the 3' end of miRNAs by trimming the 3' overhang to a final length...
2018: Hereditas
https://www.readbyqxmd.com/read/28943832/identification-of-candidate-genes-involved-in-the-sugar-metabolism-and-accumulation-during-pear-fruit-post-harvest-ripening-of-red-clapp-s-favorite-pyrus-communis-l-by-transcriptome-analysis
#3
Long Wang, Yun Chen, Suke Wang, Huabai Xue, Yanli Su, Jian Yang, Xiugen Li
BACKGROUND: Pear (Pyrus spp.) is a popular fruit that is commercially cultivated in most temperate regions. In fruits, sugar metabolism and accumulation are important factors for fruit organoleptic quality. Post-harvest ripening is a special feature of 'Red Clapp's Favorite'. RESULTS: In this study, transcriptome sequencing based on the Illumina platform generated 23.8 - 35.8 million unigenes of nine cDNA libraries constructed using RNAs from the 'Red Clapp's Favorite' pear variety with different treatments, in which 2629 new genes were discovered, and 2121 of them were annotated...
2018: Hereditas
https://www.readbyqxmd.com/read/28878591/mutations-in-the-gene-of-the-g%C3%AE-subunit-of-the-heterotrimeric-g-protein-are-the-cause-for-the-brachytic1-semi-dwarf-phenotype-in-barley-and-applicable-for-practical-breeding
#4
Ilka Braumann, Christoph Dockter, Sebastian Beier, Axel Himmelbach, Finn Lok, Udda Lundqvist, Birgitte Skadhauge, Nils Stein, Shakhira Zakhrabekova, Ruonan Zhou, Mats Hansson
BACKGROUND: Short-culm mutants have been widely used in breeding programs to increase lodging resistance. In barley (Hordeum vulgare L.), several hundreds of short-culm mutants have been isolated over the years. The objective of the present study was to identify the Brachytic1 (Brh1) semi-dwarfing gene and to test its effect on yield and malting quality. RESULTS: Double-haploid lines generated through a cross between a brh1.a mutant and the European elite malting cultivar Quench, showed good malting quality but a decrease in yield...
2018: Hereditas
https://www.readbyqxmd.com/read/28860957/mirnas-of-peripheral-blood-as-the-biomarker-of-schizophrenia
#5
REVIEW
Kuanjun He, Chuang Guo, Lin He, Yongyong Shi
The diagnosis of schizophrenia is currently based on the symptoms and bodily signs rather than on the pathological and physiological markers of the patient. In the search for new molecular targeted therapy medicines, and recurrence of early-warning indicators have become the major focus of contemporary research, because they improve diagnostic accuracy. Biomarkers reflect the physiological, physical and biochemical status of the body, and so have extensive applicability and practical significance. The ascertainment of schizophrenia biomarkers will help diagnose, stratify of disease, and treat of schizophrenia patients...
2018: Hereditas
https://www.readbyqxmd.com/read/28827983/genotypic-and-phenotypic-evaluation-of-off-type-grasses-in-hybrid-bermudagrass-cynodon-dactylon-l-pers-x-c-transvaalensis-burtt-davy-putting-greens-using-genotyping-by-sequencing-and-morphological-characterization
#6
Eric H Reasor, James T Brosnan, Margaret E Staton, Thomas Lane, Robert N Trigiano, Phillip A Wadl, Joann A Conner, Brian M Schwartz
BACKGROUND: Interspecific hybrid bermudagrass [Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy] is one of the most widely used grasses on golf courses, with cultivars derived from 'Tifgreen' or 'Tifdwarf' particularly used for putting greens. Many bermudagrass cultivars established for putting greens can be genetically unstable and lead to the occurrence of undesirable off-type grasses that vary in phenotype. The objective of this research was to genetically and phenotypically differentiate off-type grasses and hybrid cultivars...
2018: Hereditas
https://www.readbyqxmd.com/read/28794693/human-genetics-in-troubled-times-and-places
#7
REVIEW
Peter S Harper
The development of human genetics world-wide during the twentieth century, especially across Europe, has occurred against a background of repeated catastrophes, including two world wars and the ideological problems and repression posed by Nazism and Communism. The published scientific literature gives few hints of these problems and there is a danger that they will be forgotten. The First World War was largely indiscriminate in its carnage, but World War 2 and the preceding years of fascism were associated with widespread migration, especially of Jewish workers expelled from Germany, and of their children, a number of whom would become major contributors to the post-war generation of human and medical geneticists in Britain and America...
2018: Hereditas
https://www.readbyqxmd.com/read/28729817/ssr-marker-variations-in-brassica-species-provide-insight-into-the-origin-and-evolution-of-brassica-amphidiploids
#8
Ajay Kumar Thakur, Kunwar Harendra Singh, Lal Singh, Joghee Nanjundan, Yasin Jeshima Khan, Dhiraj Singh
BACKGROUND: Oilseed Brassica represents an important group of oilseed crops with a long history of evolution and cultivation. To understand the origin and evolution of Brassica amphidiploids, simple sequence repeat (SSR) markers were used to unravel genetic variations in three diploids and three amphidiploid Brassica species of U's triangle along with Eruca sativa as an outlier. RESULTS: Of 124 Brassica-derived SSR loci assayed, 100% cross-transferability was obtained for B...
2018: Hereditas
https://www.readbyqxmd.com/read/28725167/genetic-risk-between-the-cacna1i-gene-and-schizophrenia-in-chinese-uygur-population
#9
Wei Xu, Yahui Liu, Jianhua Chen, Qingli Guo, Ke Liu, Zujia Wen, Zhaowei Zhou, Zhijian Song, Juan Zhou, Lin He, Qizhong Yi, Yongyong Shi
BACKGROUND: Schizophrenia (SCZ) is a common mental disorder with high heritability, and genetic factors play a major role in the pathogenesis. Recent researches indicated that the CACNA1I involved in calcium channels probably affect the potential pathogenesis of SCZ. RESULTS: In this study, we attempted to investigate whether the CACNA1I gene contributes the risk to SCZ in the Uighur Chinese population, and performed a case-control study involving 985 patient samples and 1218 normal controls to analyze nine SNPs within the CACNA1I gene...
2018: Hereditas
https://www.readbyqxmd.com/read/28701907/adaptation-of-human-skin-color-in-various-populations
#10
REVIEW
Lian Deng, Shuhua Xu
BACKGROUND: Skin color is a well-recognized adaptive trait and has been studied extensively in humans. Understanding the genetic basis of adaptation of skin color in various populations has many implications in human evolution and medicine. DISCUSSION: Impressive progress has been made recently to identify genes associated with skin color variation in a wide range of geographical and temporal populations. In this review, we discuss what is currently known about the genetics of skin color variation...
2018: Hereditas
https://www.readbyqxmd.com/read/28690479/microarray-study-of-gene-expression-profile-to-identify-new-candidate-genes-involved-in-the-molecular-mechanism-of-leptin-induced-knee-joint-osteoarthritis-in-rat
#11
Qing Fan, Zhu Liu, Chao Shen, Hai Li, Jing Ding, Fangchun Jin, Lin Sha, Ziming Zhang
BACKGROUND: Osteoarthritis (OA) is one of the most prevalent chronic joint diseases while the precise genetic mechanism remains elusive. In this study, we investigated the gene expression profile in OA by microarray analysis. RESULTS: Histopathological characteristics of OA cartilage were examined using a rat model of leptin-induced OA. Gene expression profile of leptin-induced articular cartilage and healthy rat cartilage were compared using genome-wide microarray hybridization...
2018: Hereditas
https://www.readbyqxmd.com/read/28690478/genetic-diversity-and-structure-of-core-collection-of-winter-mushroom-flammulina-velutipes-developed-by-genomic-ssr-markers
#12
Xiao Bin Liu, Jing Li, Zhu L Yang
BACKGROUND: A core collection is a subset of an entire collection that represents as much of the genetic diversity of the entire collection as possible. The establishment of a core collection for crops is practical for efficient management and use of germplasm. However, the establishment of a core collection of mushrooms is still in its infancy, and no established core collection of the economically important species Flammulina velutipes has been reported. RESULTS: We established the first core collection of F...
2018: Hereditas
https://www.readbyqxmd.com/read/28690477/identity-by-descent-refines-mapping-of-candidate-regions-for-preaxial-polydactyly-ii-iii-in-a-large-chinese-pedigree
#13
Xingyan Yang, Quankuan Shen, Xierzhatijiang Sulaiman, Hequn Liu, Minsheng Peng, Yaping Zhang
Preaxial polydactyly (PPD) is congenital hand malformation characterized by the duplication of digit. Herein, we scan the genome-wide SNPs for a large Chinese family with PPD-II/III. We employ the refined IBD algorithm to identify the identity-by-decent (IBD) segments and compare the frequency among the patients and normal relatives. A total of 72 markers of 0.01 percentile of the permutation are identified as the peak signals. Among of them, 57markers locate on chromosome 7q36 which is associated with PPD...
2018: Hereditas
https://www.readbyqxmd.com/read/28559761/a-systematic-review-of-rye-secale-cereale-l-as-a-source-of-resistance-to-pathogens-and-pests-in-wheat-triticum-aestivum-l
#14
REVIEW
Leonardo A Crespo-Herrera, Larisa Garkava-Gustavsson, Inger Åhman
Wheat is globally one of the most important crops. With the current human population growth rate, there is an increasing need to raise wheat productivity by means of plant breeding, along with development of more efficient and sustainable agricultural systems. Damage by pathogens and pests, in combination with adverse climate effects, need to be counteracted by incorporating new germplasm that makes wheat more resistant/tolerant to such stress factors. Rye has been used as a source for improved resistance to pathogens and pests in wheat during more than 50 years...
2017: Hereditas
https://www.readbyqxmd.com/read/28529470/microdissection-of-the-ah01-chromosome-in-upland-cotton-and-microcloning-of-resistance-gene-anologs-from-the-single-chromosome
#15
Xinchuan Cao, Yuling Liu, Zhen Liu, Fang Liu, Yalei Wu, Zhongli Zhou, Xiaoyan Cai, Xingxing Wang, Zhenmei Zhang, Yuhong Wang, Zhimin Luo, Renhai Peng, Kunbo Wang
BACKGROUND: Chromosome microdissection is one of the most important techniques in molecular cytogenetic research. Cotton (Gossypium Linnaeus, 1753) is the main natural fiber crop in the world. The resistance gene analog (RGA) cloning after its single chromosome microdissection can greatly promote cotton genome research and breeding. RESULTS: Using the linker adaptor PCR (LA-PCR) with the primers of rice disease-resistance homologues, three nucleotide sequences PS016 (KU051681), PS054 (KU051682), and PS157 (KU051680) were obtained from the chromosome Ah01 of upland cotton (cv...
2017: Hereditas
https://www.readbyqxmd.com/read/28529469/a-comparative-genomics-approach-revealed-evolutionary-dynamics-of-microsatellite-imperfection-and-conservation-in-genus-gossypium
#16
Muhammad Mahmood Ahmed, Chao Shen, Anam Qadir Khan, Muhammad Atif Wahid, Muhammad Shaban, Zhongxu Lin
BACKGROUND: Ongoing molecular processes in a cell could target microsatellites, a kind of repetitive DNA, owing to length variations and motif imperfection. Mutational mechanisms underlying such kind of genetic variations have been extensively investigated in diverse organisms. However, obscure impact of ploidization, an evolutionary process of genome content duplication prevails mostly in plants, on non-coding DNA is poorly understood. RESULTS: Genome sequences of diversely originated plant species were examined for genome-wide motif imperfection pattern, and various analytical tools were employed to canvass characteristic relationships among repeat density, imperfection and length of microsatellites...
2017: Hereditas
https://www.readbyqxmd.com/read/28529468/contrasting-patterns-of-nucleotide-polymorphism-suggest-different-selective-regimes-within-different-parts-of-the-pgic1-gene-in-festuca-ovina-l
#17
Yuan Li, Bengt Hansson, Lena Ghatnekar, Honor C Prentice
BACKGROUND: Phosphoglucose isomerase (PGI, EC 5.3.1.9) is an essential metabolic enzyme in all eukaryotes. An earlier study of the PgiC1 gene, which encodes cytosolic PGI in the grass Festuca ovina L., revealed a marked difference in the levels of nucleotide polymorphism between the 5' and 3' portions of the gene. METHODS: In the present study, we characterized the sequence polymorphism in F. ovina PgiC1 in more detail and examined possible explanations for the non-uniform pattern of nucleotide polymorphism across the gene...
2017: Hereditas
https://www.readbyqxmd.com/read/28484361/analysis-of-differentially-expressed-genes-and-adaptive-mechanisms-of-prunus-triloba-lindl-under-alkaline-stress
#18
Jia Liu, Yongqing Wang, Qingtian Li
BACKGROUND: Prunus triloba Lindl. is a naturally salt-alkaline-tolerant plant with several unique characteristics, and it can be used as the rootstock of Chinese plum (Prunus salicina Lindl.) in saline-alkaline soils. To comprehensively investigate the alkaline acclimation mechanisms in P. triloba, a series of analyses were conducted under alkaline stress, including analyses of the kinetics of molecular and physiological changes, and leaf microstructure. RESULTS: To understand the kinetics of molecular changes under short-term alkaline stress, we used Illumina HiSeq 2500 platform to identify alkaline stress-related differentially expressed genes (DEGs) in P...
2017: Hereditas
https://www.readbyqxmd.com/read/28461811/genetic-diversity-and-population-structure-analysis-of-kala-bhat-glycine-max-l-merrill-genotypes-using-ssr-markers
#19
Yegappa Hipparagi, Rakesh Singh, Debjani Roy Choudhury, Veena Gupta
BACKGROUND: Kala bhat (Black soybean) is an important legume crop in Uttarakhand state, India, due to its nutritional and medicinal properties. In the current study, the genetic variabilities present in Kala bhat were estimated using SSR markers and its variability was compared with other improved soybean varieties cultivated in Uttarakhand state, India. RESULTS: Seventy-five genotypes cultivated in different districts of Uttarakhand were collected, and molecular analysis was done using 21 SSR markers...
2017: Hereditas
https://www.readbyqxmd.com/read/28461810/ancient-role-of-ten-m-odz-in-segmentation-and-the-transition-from-sequential-to-syncytial-segmentation
#20
Axel Hunding, Stefan Baumgartner
BACKGROUND: Until recently, mechanisms of segmentation established for Drosophila served as a paradigm for arthropod segmentation. However, with the discovery of gene expression waves in vertebrate segmentation, another paradigm based on oscillations linked to axial growth was established. The Notch pathway and hairy delay oscillator are basic components of this mechanism, as is the wnt pathway. With the establishment of oscillations during segmentation of the beetle Tribolium, a common segmentation mechanism may have been present in the last common ancestor of vertebrates and arthropods...
2017: Hereditas
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