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Hereditas

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https://www.readbyqxmd.com/read/30305809/enhancement-of-grain-number-per-spike-by-rna-interference-of-cytokinin-oxidase-2-gene-in-bread-wheat
#1
Yulian Li, Guoqi Song, Jie Gao, Shujuan Zhang, Rongzhi Zhang, Wei Li, Mingli Chen, Min Liu, Xianchun Xia, Thierry Risacher, Genying Li
Background: This study aimed to validate the function of CKX gene on grain numbers in wheat. Methods: we constructed and transformed a RNA interference expression vector of TaCKX2.4 in bread wheat line NB1. Southern blotting analysis was used to select transgenic plants with single copy. The expression of TaCKX2.4 gene was estimated by Quantitative real-time PCR (qRT-PCR) analysis. Finally, the relation between expression of TaCKX2.4 gene and grain numbers was validated...
2018: Hereditas
https://www.readbyqxmd.com/read/30279644/long-read-sequencing-identified-a-causal-structural-variant-in-an-exome-negative-case-and-enabled-preimplantation-genetic-diagnosis
#2
Hefan Miao, Jiapeng Zhou, Qi Yang, Fan Liang, Depeng Wang, Na Ma, Bodi Gao, Juan Du, Ge Lin, Kai Wang, Qianjun Zhang
Background: For a proportion of individuals judged clinically to have a recessive Mendelian disease, only one heterozygous pathogenic variant can be found from clinical whole exome sequencing (WES), posing a challenge to genetic diagnosis and genetic counseling. One possible reason is the limited ability to detect disease causal structural variants (SVs) from short reads sequencing technologies. Long reads sequencing can produce longer reads (typically 1000 bp or longer), therefore offering greatly improved ability to detect SVs that may be missed by short-read sequencing...
2018: Hereditas
https://www.readbyqxmd.com/read/30279643/variations-in-morphological-traits-of-bermudagrass-and-relationship-with-soil-and-climate-along-latitudinal-gradients
#3
Jingxue Zhang, Miaoli Wang, Zhipeng Guo, Yongzhuo Guan, Yuxia Guo, Xuebing Yan
Background: This complex environmental heterogeneity coupled with the long-standing history offers scenario suitable for and favoring the evolution and existence of variation of morphological traits. Methods: In this study, we measured 10 morphological traits of 310 Cynodon dactylon individuals sampled at 16 different locations along latitudinal gradients between 22°35'N and 36°18'N to reveal phenotypic plasticity influenced by latitude. In addition, the relationships between morphological variation and soil nutrient and climate factors were analyzed...
2018: Hereditas
https://www.readbyqxmd.com/read/30275809/development-of-17-polymorphic-microsatellite-loci-from-jeju-striped-field-mouse-apodemus-agrarius-chejuensis-rodentia-muridae-by-454-pyrosequencing
#4
Han-Na Kim, Han-Ul Kim, Yeong-Seok Jo, Jongwoo Jung
Background: The striped field mouse, Apodemus agrarius , is the most common mammal in Korea. Although microsatellite loci for the species have been identified from populations in southwestern China, amplification of those markers for Korean populations have been unsuccessful. The complicated taxonomy of Korean striped field mouse including populations on Jeju Island ( A. a chejuensis ) necessitates identification of additional molecular markers. Findings: We applied 454 pyrosequencing systems to develop a suite of microsatellite markers...
2018: Hereditas
https://www.readbyqxmd.com/read/30258345/comparative-analysis-of-the-genetic-variability-within-the-q-type-c2h2-zinc-finger-transcription-factors-in-the-economically-important-cabbage-canola-and-chinese-cabbage-genomes
#5
Susan D Lawrence, Nicole G Novak
Background: Brassica oleracea, B. rapa and B. napus encompass many economically important vegetable and oil crops; such as cabbage, broccoli, canola and Chinese cabbage. The genome sequencing of these species allows for gene discovery with an eye towards discerning the natural variability available for future breeding. The Q-type C2H2 zinc-finger protein (ZFP) transcription factors contain zinc finger motifs with a conserved QALGGH as part of the motif and they may play a critical role in the plants response to stress...
2018: Hereditas
https://www.readbyqxmd.com/read/30220899/seeing-is-believing-the-bicoid-protein-reveals-its-path
#6
Stefan Baumgartner
In this commentary, I will review the latest findings on the Bicoid (Bcd) morphogen in Drosophila , a paradigm for gradient formation taught to biology students for more than two decades. "Seeing is believing" also summarizes the erroneous steps that were needed to elucidate the mechanisms of gradient formation and the path of movement of Bcd. Initially proclaimed as a dogma in 1988 and later incorporated into the SDD model where the broad diffusion of Bcd throughout the embryo was the predominant step leading to gradient formation, the SDD model was irrefutable for more than two decades until first doubts were raised in 2007 regarding the diffusion properties of Bcd associated with the SDD model...
2018: Hereditas
https://www.readbyqxmd.com/read/30202398/overexpression-of-the-drosophila-atr-homologous-checkpoint-kinase-mei-41-induces-a-g2-m-checkpoint-in-drosophila-imaginal-tissue
#7
Fabienne E Bayer, Mirjam Zimmermann, Anette Preiss, Anja C Nagel
Background: DNA damage generally results in the activation of ATM/ATR kinases and the downstream checkpoint kinases Chk1/Chk2. In Drosophila melanogaster, the ATR homologue meiotic 41 ( mei-41) is pivotal to DNA damage repair and cell cycle checkpoint signalling. Although various mei-41 mutant alleles have been analyzed in the past, no gain-of-function allele is yet available. To fill this gap, we have generated transgenic flies allowing temporal and tissue-specific induction of mei-41...
2018: Hereditas
https://www.readbyqxmd.com/read/30123102/characterization-of-tadreb1-in-wheat-genotypes-with-different-seed-germination-under-osmotic-stress
#8
Meng Liu, Zeng Wang, Hong-Mei Xiao, Yan Yang
Background: The cis-acting element DRE/CRT plays an important role in activating gene expression responsive to osmotic stress, low temperature and high-salinity. DREB1 / CBF genes encode DRE-binding proteins with the function as transcript activators. TaDREB1 was also found to be induced by osmotic stress. Methods: The dates of osmotic stress was assessed by seed germination drought resistance index; the full-length cDNA sequences of TaDREB1 gene were downloaded from NCBI datebase; identification of allelic variation and transcript expression were assessed by PCR and semi-quantitive RT-PCR analysis, respectively...
2018: Hereditas
https://www.readbyqxmd.com/read/30083084/the-genetic-locus-underlying-red-foliage-and-fruit-skin-traits-is-mapped-to-the-same-location-in-the-two-pear-bud-mutants-red-zaosu-and-max-red-bartlett
#9
Huabai Xue, Suke Wang, Jia-Long Yao, Xiaoli Zhang, Jian Yang, Long Wang, Yanli Su, Lei Chen, Huirong Zhang, Xiugen Li
Background: Red-skinned pears are attractive to consumers because of their aesthetic appeal and the antioxidant-associated health benefits provided by the anthocyanins in their red skin. In China, the 'Red Zaosu' (RZS) red bud mutation of the Zaosu (ZS) pear has been used as a parent in Asian pear breeding to generate new cultivars with crispy red fruit and red tender shoots resembling those of the 'Max Red Bartlett' (MRB) pears. Results: In this study, a segregation ratio of 1:1 was observed between plants with red or green shoots in four families with RZS as the only red shoot gene donor parent, suggesting that the red shoot trait of RZS is associated with a dominant gene...
2018: Hereditas
https://www.readbyqxmd.com/read/30026675/a-novel-rasa1-mutation-causing-capillary-malformation-arteriovenous-malformation-cm-avm-the-first-genetic-clinical-report-in-east-asia
#10
Ren Cai, Fatao Liu, Chen Hua, Zhang Yu, Michele Ramien, Claudia Malic, Wenxin Yu, Xiaolin Zhang, Yun Liu, Yunbo Jin, Xun Hu, Xiaoxi Lin
Capillary malformation-arteriovenous malformation (CM-AVM) is a clinical entity newly identified in 2003 that is caused by mutation of the RASA-1 gene, which encodes the protein p120-RasGAP. To date, most of the clinical reports on CM-AVM in the literature involve samples entirely consisting of Caucasians of European and North American descent, while reports from China or East Asia are few. Here, we describe a genetic clinical report of CM-AVM. Sequencing revealed a novel stop mutation in the RASA-1 gene causing loss of function (LOF) of the RasGAP domain...
2018: Hereditas
https://www.readbyqxmd.com/read/29785177/characterization-of-new-microsatellite-markers-based-on-the-transcriptome-sequencing-of-clematis-finetiana
#11
Zhigao Liu, Weili Shao, Yamei Shen, Mengcheng Ji, Wenchao Chen, Ying Ye, Yongbao Shen
Background: Clematis is the biggest genus in the family Ranunculaceae with about 300 species. Clematis is also a globally important commercial group of flowers, especially in the United States and European countries. Their petals with different colors and shapes make the genus the "Queen of the Vines". However, the genomic information and phylogeny of Clematis based on existing molecular studies are limited. In this paper, new microsatellites (SSR) markers were identified from the transcriptome data of C...
2018: Hereditas
https://www.readbyqxmd.com/read/29773972/genetic-diversity-and-structure-of-tea-plant-in-qinba-area-in-china-by-three-types-of-molecular-markers
#12
Yu Zhang, Xiaojuan Zhang, Xi Chen, Wang Sun, Jiao Li
Background: Qinba area has a long history of tea planting and is a northernmost region in China where Camellia sinensis L. is grown. In order to provide basic data for selection and optimization of molecular markers of tea plants. 118 markers, including 40 EST-SSR, 40 SRAP and 38 SCoT markers were used to evaluate the genetic diversity of 50 tea plant ( Camellia sinensis. ) samples collected from Qinb. tea germplasm, assess population structure. Results: In this study, a total of 414 alleles were obtained using 38 pairs of SCoT primers, with an average of 10...
2018: Hereditas
https://www.readbyqxmd.com/read/29760609/identification-of-potential-crucial-genes-and-construction-of-microrna-mrna-negative-regulatory-networks-in-osteosarcoma
#13
Yue Pan, Lingyun Lu, Junquan Chen, Yong Zhong, Zhehao Dai
Background: This study aimed to identify potential crucial genes and construction of microRNA-mRNA negative regulatory networks in osteosarcoma by comprehensive bioinformatics analysis. Methods: Data of gene expression profiles (GSE28424) and miRNA expression profiles (GSE28423) were downloaded from GEO database. The differentially expressed genes (DEGs) and miRNAs (DEMIs) were obtained by R Bioconductor packages. Functional and enrichment analyses of selected genes were performed using DAVID database...
2018: Hereditas
https://www.readbyqxmd.com/read/29686601/molecular-markers-associated-with-aluminium-tolerance-in-sorghum-bicolor
#14
Emily Jepkosgei Too, Augustino Osoro Onkware, Beatrice Ang'iyo Were, Samuel Gudu, Anders Carlsson, Mulatu Geleta
Background: Sorghum ( Sorghum bicolor , L. Moench) production in many agro-ecologies is constrained by a variety of stresses, including high levels of aluminium (Al) commonly found in acid soils. Therefore, for such soils, growing Al tolerant cultivars is imperative for high productivity. Methods: In this study, molecular markers associated with Al tolerance were identified using a mapping population developed by crossing two contrasting genotypes for this trait...
2018: Hereditas
https://www.readbyqxmd.com/read/29636655/genetic-structure-divergence-and-admixture-of-han-chinese-japanese-and-korean-populations
#15
Yuchen Wang, Dongsheng Lu, Yeun-Jun Chung, Shuhua Xu
Background: Han Chinese, Japanese and Korean, the three major ethnic groups of East Asia, share many similarities in appearance, language and culture etc., but their genetic relationships, divergence times and subsequent genetic exchanges have not been well studied. Results: We conducted a genome-wide study and evaluated the population structure of 182 Han Chinese, 90 Japanese and 100 Korean individuals, together with the data of 630 individuals representing 8 populations wordwide...
2018: Hereditas
https://www.readbyqxmd.com/read/29483849/comparative-transcriptome-reveal-the-potential-adaptive-evolutionary-genes-in-andrias-davidianus
#16
Qiaomu Hu, Quanhe Wang, Yan Meng, Haifeng Tian, Hanbing Xiao
To search the evidence of molecular evolution mechanism for aquatic and cave habitat in Andrias davidianus , the evolution analysis was carried out among several species transcriptome data. The transcriptome data of Notophthalmus viridescens , Xenopus tropicalis, Cynops pyrrhogaster, Hynobius chinensis and A. davidianus were obtained from the Genbank and reassembled except Xenopus tropicalis . The BLAST search of transcriptome data obtained 1244 single-copy orthologous genes among five species . A phylogenetic tree showed A...
2018: Hereditas
https://www.readbyqxmd.com/read/29371858/bioinformatics-based-identification-of-mir-542-5p-as-a-predictive-biomarker-in-breast-cancer-therapy
#17
Qiong-Ni Zhu, Helen Renaud, Ying Guo
Background: Tamoxifen is the first-line hormone therapy for estrogen receptor alpha positive (ERα+) breast cancer. However, about 40% of patients with ERα + breast cancer who receive tamoxifen therapy eventually develop resistance resulting in a poor prognosis. The aim of this study was to mine available data sets in the Gene Expression Omnibus (GEO) database, including in vitro (cell lines) and in vivo (tissue samples), and to identify all miRNAs associated with tamoxifen resistance (TamR) in breast cancer...
2018: Hereditas
https://www.readbyqxmd.com/read/29308060/further-evidence-for-the-genetic-association-between-cacna1i-and-schizophrenia
#18
Yijun Xie, Di Huang, Li Wei, Xiong-Jian Luo
Background: Recent large-scale genome-wide association studies (GWAS) have showed that the neuronal calcium signaling has pivotal roles in schizophrenia (SCZ) in populations of European of ancestry. However, it is not known if calcium signaling pathway genes are also associated with SCZ in Han Chinese population. Methods: Here we investigated the association between genetic variants in three calcium signaling pathway genes ( CACNB2 , CACNA1C and CACNA1I ) and SCZ in 1615 SCZ cases and 1597 controls...
2018: Hereditas
https://www.readbyqxmd.com/read/29123463/switchgrass-pvdreb1c-plays-opposite-roles-in-plant-cold-and-salt-tolerance-in-transgenic-tobacco
#19
Wuwu Wen, Zheni Xie, Guohui Yu, Chengliang Zhao, Jing Zhang, Linkai Huang, Bin Xu, Bingru Huang
Background: The C-repeat-binding factors/DRE-binding factors (CBF/DREBs) comprise a key transcription factor family involved in plant stress tolerance. Yet, there is limited information about switchgrass DREB genes and their functional roles. Results: In this study, four cold-inducible PvDREB1s were identified from switchgrass ( Panicum virgatum ), among which PvDREB1C was the one responded to cold stress later than the other three PvDREB1s . Yet, ectopic overexpression of PvDREB1C led to significantly compromised, instead of improved cold tolerance in transgenic tobacco...
2018: Hereditas
https://www.readbyqxmd.com/read/29075165/characterizing-the-transcriptome-and-microsatellite-markers-for-almond-amygdalus-communis-l-using-the-illumina-sequencing-platform
#20
Linsen Zhang, Xiaoni Yang, Xiangning Qi, Chunhui Guo, Zhaobin Jing
BACKGROUND: The almond tree ( Prunus amygdalus Batsch) is an important nut tree grown in subtropical regions that produces nutrient-rich nuts. However, a paucity of genomic information and DNA markers has restricted the development of modern breeding technologies for almond trees. RESULTS: In this study, almonds were sequenced with Illumina paired-end sequencing technology to obtain transcriptome data and develop simple sequence repeats (SSR) markers. We generated approximately 64 million clean reads from the various tissues of mixed almonds, and a total of 42,135 unigenes with an average length of 988 bp were obtained in the present study...
2018: Hereditas
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