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Hereditas

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https://www.readbyqxmd.com/read/30083084/the-genetic-locus-underlying-red-foliage-and-fruit-skin-traits-is-mapped-to-the-same-location-in-the-two-pear-bud-mutants-red-zaosu-and-max-red-bartlett
#1
Huabai Xue, Suke Wang, Jia-Long Yao, Xiaoli Zhang, Jian Yang, Long Wang, Yanli Su, Lei Chen, Huirong Zhang, Xiugen Li
Background: Red-skinned pears are attractive to consumers because of their aesthetic appeal and the antioxidant-associated health benefits provided by the anthocyanins in their red skin. In China, the 'Red Zaosu' (RZS) red bud mutation of the Zaosu (ZS) pear has been used as a parent in Asian pear breeding to generate new cultivars with crispy red fruit and red tender shoots resembling those of the 'Max Red Bartlett' (MRB) pears. Results: In this study, a segregation ratio of 1:1 was observed between plants with red or green shoots in four families with RZS as the only red shoot gene donor parent, suggesting that the red shoot trait of RZS is associated with a dominant gene...
2018: Hereditas
https://www.readbyqxmd.com/read/30026675/a-novel-rasa1-mutation-causing-capillary-malformation-arteriovenous-malformation-cm-avm-the-first-genetic-clinical-report-in-east-asia
#2
Ren Cai, Fatao Liu, Chen Hua, Zhang Yu, Michele Ramien, Claudia Malic, Wenxin Yu, Xiaolin Zhang, Yun Liu, Yunbo Jin, Xun Hu, Xiaoxi Lin
Capillary malformation-arteriovenous malformation (CM-AVM) is a clinical entity newly identified in 2003 that is caused by mutation of the RASA-1 gene, which encodes the protein p120-RasGAP. To date, most of the clinical reports on CM-AVM in the literature involve samples entirely consisting of Caucasians of European and North American descent, while reports from China or East Asia are few. Here, we describe a genetic clinical report of CM-AVM. Sequencing revealed a novel stop mutation in the RASA-1 gene causing loss of function (LOF) of the RasGAP domain...
2018: Hereditas
https://www.readbyqxmd.com/read/29785177/characterization-of-new-microsatellite-markers-based-on-the-transcriptome-sequencing-of-clematis-finetiana
#3
Zhigao Liu, Weili Shao, Yamei Shen, Mengcheng Ji, Wenchao Chen, Ying Ye, Yongbao Shen
Background: Clematis is the biggest genus in the family Ranunculaceae with about 300 species. Clematis is also a globally important commercial group of flowers, especially in the United States and European countries. Their petals with different colors and shapes make the genus the "Queen of the Vines". However, the genomic information and phylogeny of Clematis based on existing molecular studies are limited. In this paper, new microsatellites (SSR) markers were identified from the transcriptome data of C...
2018: Hereditas
https://www.readbyqxmd.com/read/29773972/genetic-diversity-and-structure-of-tea-plant-in-qinba-area-in-china-by-three-types-of-molecular-markers
#4
Yu Zhang, Xiaojuan Zhang, Xi Chen, Wang Sun, Jiao Li
Background: Qinba area has a long history of tea planting and is a northernmost region in China where Camellia sinensis L. is grown. In order to provide basic data for selection and optimization of molecular markers of tea plants. 118 markers, including 40 EST-SSR, 40 SRAP and 38 SCoT markers were used to evaluate the genetic diversity of 50 tea plant ( Camellia sinensis. ) samples collected from Qinb. tea germplasm, assess population structure. Results: In this study, a total of 414 alleles were obtained using 38 pairs of SCoT primers, with an average of 10...
2018: Hereditas
https://www.readbyqxmd.com/read/29760609/identification-of-potential-crucial-genes-and-construction-of-microrna-mrna-negative-regulatory-networks-in-osteosarcoma
#5
Yue Pan, Lingyun Lu, Junquan Chen, Yong Zhong, Zhehao Dai
Background: This study aimed to identify potential crucial genes and construction of microRNA-mRNA negative regulatory networks in osteosarcoma by comprehensive bioinformatics analysis. Methods: Data of gene expression profiles (GSE28424) and miRNA expression profiles (GSE28423) were downloaded from GEO database. The differentially expressed genes (DEGs) and miRNAs (DEMIs) were obtained by R Bioconductor packages. Functional and enrichment analyses of selected genes were performed using DAVID database...
2018: Hereditas
https://www.readbyqxmd.com/read/29686601/molecular-markers-associated-with-aluminium-tolerance-in-sorghum-bicolor
#6
Emily Jepkosgei Too, Augustino Osoro Onkware, Beatrice Ang'iyo Were, Samuel Gudu, Anders Carlsson, Mulatu Geleta
Background: Sorghum ( Sorghum bicolor , L. Moench) production in many agro-ecologies is constrained by a variety of stresses, including high levels of aluminium (Al) commonly found in acid soils. Therefore, for such soils, growing Al tolerant cultivars is imperative for high productivity. Methods: In this study, molecular markers associated with Al tolerance were identified using a mapping population developed by crossing two contrasting genotypes for this trait...
2018: Hereditas
https://www.readbyqxmd.com/read/29636655/genetic-structure-divergence-and-admixture-of-han-chinese-japanese-and-korean-populations
#7
Yuchen Wang, Dongsheng Lu, Yeun-Jun Chung, Shuhua Xu
Background: Han Chinese, Japanese and Korean, the three major ethnic groups of East Asia, share many similarities in appearance, language and culture etc., but their genetic relationships, divergence times and subsequent genetic exchanges have not been well studied. Results: We conducted a genome-wide study and evaluated the population structure of 182 Han Chinese, 90 Japanese and 100 Korean individuals, together with the data of 630 individuals representing 8 populations wordwide...
2018: Hereditas
https://www.readbyqxmd.com/read/29483849/comparative-transcriptome-reveal-the-potential-adaptive-evolutionary-genes-in-andrias-davidianus
#8
Qiaomu Hu, Quanhe Wang, Yan Meng, Haifeng Tian, Hanbing Xiao
To search the evidence of molecular evolution mechanism for aquatic and cave habitat in Andrias davidianus , the evolution analysis was carried out among several species transcriptome data. The transcriptome data of Notophthalmus viridescens , Xenopus tropicalis, Cynops pyrrhogaster, Hynobius chinensis and A. davidianus were obtained from the Genbank and reassembled except Xenopus tropicalis . The BLAST search of transcriptome data obtained 1244 single-copy orthologous genes among five species . A phylogenetic tree showed A...
2018: Hereditas
https://www.readbyqxmd.com/read/29371858/bioinformatics-based-identification-of-mir-542-5p-as-a-predictive-biomarker-in-breast-cancer-therapy
#9
Qiong-Ni Zhu, Helen Renaud, Ying Guo
Background: Tamoxifen is the first-line hormone therapy for estrogen receptor alpha positive (ERα+) breast cancer. However, about 40% of patients with ERα + breast cancer who receive tamoxifen therapy eventually develop resistance resulting in a poor prognosis. The aim of this study was to mine available data sets in the Gene Expression Omnibus (GEO) database, including in vitro (cell lines) and in vivo (tissue samples), and to identify all miRNAs associated with tamoxifen resistance (TamR) in breast cancer...
2018: Hereditas
https://www.readbyqxmd.com/read/29308060/further-evidence-for-the-genetic-association-between-cacna1i-and-schizophrenia
#10
Yijun Xie, Di Huang, Li Wei, Xiong-Jian Luo
Background: Recent large-scale genome-wide association studies (GWAS) have showed that the neuronal calcium signaling has pivotal roles in schizophrenia (SCZ) in populations of European of ancestry. However, it is not known if calcium signaling pathway genes are also associated with SCZ in Han Chinese population. Methods: Here we investigated the association between genetic variants in three calcium signaling pathway genes ( CACNB2 , CACNA1C and CACNA1I ) and SCZ in 1615 SCZ cases and 1597 controls...
2018: Hereditas
https://www.readbyqxmd.com/read/29123463/switchgrass-pvdreb1c-plays-opposite-roles-in-plant-cold-and-salt-tolerance-in-transgenic-tobacco
#11
Wuwu Wen, Zheni Xie, Guohui Yu, Chengliang Zhao, Jing Zhang, Linkai Huang, Bin Xu, Bingru Huang
Background: The C-repeat-binding factors/DRE-binding factors (CBF/DREBs) comprise a key transcription factor family involved in plant stress tolerance. Yet, there is limited information about switchgrass DREB genes and their functional roles. Results: In this study, four cold-inducible PvDREB1s were identified from switchgrass ( Panicum virgatum ), among which PvDREB1C was the one responded to cold stress later than the other three PvDREB1s . Yet, ectopic overexpression of PvDREB1C led to significantly compromised, instead of improved cold tolerance in transgenic tobacco...
2018: Hereditas
https://www.readbyqxmd.com/read/29075165/characterizing-the-transcriptome-and-microsatellite-markers-for-almond-amygdalus-communis-l-using-the-illumina-sequencing-platform
#12
Linsen Zhang, Xiaoni Yang, Xiangning Qi, Chunhui Guo, Zhaobin Jing
BACKGROUND: The almond tree ( Prunus amygdalus Batsch) is an important nut tree grown in subtropical regions that produces nutrient-rich nuts. However, a paucity of genomic information and DNA markers has restricted the development of modern breeding technologies for almond trees. RESULTS: In this study, almonds were sequenced with Illumina paired-end sequencing technology to obtain transcriptome data and develop simple sequence repeats (SSR) markers. We generated approximately 64 million clean reads from the various tissues of mixed almonds, and a total of 42,135 unigenes with an average length of 988 bp were obtained in the present study...
2018: Hereditas
https://www.readbyqxmd.com/read/28974924/regulatory-pathway-analysis-of-coat-color-genes-in-mongolian-horses
#13
Bei Li, Xiaolong He, Yiping Zhao, Dongyi Bai, Wunierfu Shiraigo, Qinan Zhao, Dugarjaviin Manglai
BACKGROUND: Studies on the molecular genetics of horse skin pigmentation have typically focused on very few genes and proteins. In this study, we used Illumina sequencing to determine the global gene expression profiles in horses with white-colored coats and those with black-colored coats, with the goal of identifying novel genes that could regulate horse coat color. RESULTS: Genes encoding ribosomal-associated proteins were highly expressed in horse skin. We found a total of 231 unigenes that were differentially expressed between horses with white coats and horses with black coats; 119 were down-regulated, and 112 were up-regulated...
2018: Hereditas
https://www.readbyqxmd.com/read/28974923/-drosophila-exoribonuclease-nibbler-is-a-tumor-suppressor-acts-within-the-rna-i-machinery-and-is-not-enriched-in-the-nuage-during-early-oogenesis
#14
Casimiro Castillejo-López, Xiaoli Cai, Khalid Fahmy, Stefan Baumgartner
BACKGROUND: micro RNAs (miRNAs) are important regulators of many biological pathways. A plethora of steps are required to form, from a precursor, the mature miRNA that eventually acts on its target RNA to repress its expression or to inhibit translation. Recently, Drosophila nibbler ( nbr ) has been shown to be an important player in the maturation process of miRNA and piRNA. Nbr is an exoribonuclease which helps to shape the 3' end of miRNAs by trimming the 3' overhang to a final length...
2018: Hereditas
https://www.readbyqxmd.com/read/28943832/identification-of-candidate-genes-involved-in-the-sugar-metabolism-and-accumulation-during-pear-fruit-post-harvest-ripening-of-red-clapp-s-favorite-pyrus-communis-l-by-transcriptome-analysis
#15
Long Wang, Yun Chen, Suke Wang, Huabai Xue, Yanli Su, Jian Yang, Xiugen Li
BACKGROUND: Pear ( Pyrus spp.) is a popular fruit that is commercially cultivated in most temperate regions. In fruits, sugar metabolism and accumulation are important factors for fruit organoleptic quality. Post-harvest ripening is a special feature of 'Red Clapp's Favorite'. RESULTS: In this study, transcriptome sequencing based on the Illumina platform generated 23.8 - 35.8 million unigenes of nine cDNA libraries constructed using RNAs from the 'Red Clapp's Favorite' pear variety with different treatments, in which 2629 new genes were discovered, and 2121 of them were annotated...
2018: Hereditas
https://www.readbyqxmd.com/read/28878591/mutations-in-the-gene-of-the-g%C3%AE-subunit-of-the-heterotrimeric-g-protein-are-the-cause-for-the-brachytic1-semi-dwarf-phenotype-in-barley-and-applicable-for-practical-breeding
#16
Ilka Braumann, Christoph Dockter, Sebastian Beier, Axel Himmelbach, Finn Lok, Udda Lundqvist, Birgitte Skadhauge, Nils Stein, Shakhira Zakhrabekova, Ruonan Zhou, Mats Hansson
BACKGROUND: Short-culm mutants have been widely used in breeding programs to increase lodging resistance. In barley ( Hordeum vulgare L.), several hundreds of short-culm mutants have been isolated over the years. The objective of the present study was to identify the Brachytic1 ( Brh1 ) semi-dwarfing gene and to test its effect on yield and malting quality. RESULTS: Double-haploid lines generated through a cross between a brh1.a mutant and the European elite malting cultivar Quench, showed good malting quality but a decrease in yield...
2018: Hereditas
https://www.readbyqxmd.com/read/28860957/mirnas-of-peripheral-blood-as-the-biomarker-of-schizophrenia
#17
REVIEW
Kuanjun He, Chuang Guo, Lin He, Yongyong Shi
The diagnosis of schizophrenia is currently based on the symptoms and bodily signs rather than on the pathological and physiological markers of the patient. In the search for new molecular targeted therapy medicines, and recurrence of early-warning indicators have become the major focus of contemporary research, because they improve diagnostic accuracy. Biomarkers reflect the physiological, physical and biochemical status of the body, and so have extensive applicability and practical significance. The ascertainment of schizophrenia biomarkers will help diagnose, stratify of disease, and treat of schizophrenia patients...
2018: Hereditas
https://www.readbyqxmd.com/read/28827983/genotypic-and-phenotypic-evaluation-of-off-type-grasses-in-hybrid-bermudagrass-cynodon-dactylon-l-pers-x-c-transvaalensis-burtt-davy-putting-greens-using-genotyping-by-sequencing-and-morphological-characterization
#18
Eric H Reasor, James T Brosnan, Margaret E Staton, Thomas Lane, Robert N Trigiano, Phillip A Wadl, Joann A Conner, Brian M Schwartz
BACKGROUND: Interspecific hybrid bermudagrass [ Cynodon dactylon (L.) Pers. x C. transvaalensis Burtt-Davy] is one of the most widely used grasses on golf courses, with cultivars derived from 'Tifgreen' or 'Tifdwarf' particularly used for putting greens. Many bermudagrass cultivars established for putting greens can be genetically unstable and lead to the occurrence of undesirable off-type grasses that vary in phenotype. The objective of this research was to genetically and phenotypically differentiate off-type grasses and hybrid cultivars...
2018: Hereditas
https://www.readbyqxmd.com/read/28794693/human-genetics-in-troubled-times-and-places
#19
REVIEW
Peter S Harper
The development of human genetics world-wide during the twentieth century, especially across Europe, has occurred against a background of repeated catastrophes, including two world wars and the ideological problems and repression posed by Nazism and Communism. The published scientific literature gives few hints of these problems and there is a danger that they will be forgotten. The First World War was largely indiscriminate in its carnage, but World War 2 and the preceding years of fascism were associated with widespread migration, especially of Jewish workers expelled from Germany, and of their children, a number of whom would become major contributors to the post-war generation of human and medical geneticists in Britain and America...
2018: Hereditas
https://www.readbyqxmd.com/read/28729817/ssr-marker-variations-in-brassica-species-provide-insight-into-the-origin-and-evolution-of-brassica-amphidiploids
#20
Ajay Kumar Thakur, Kunwar Harendra Singh, Lal Singh, Joghee Nanjundan, Yasin Jeshima Khan, Dhiraj Singh
BACKGROUND: Oilseed Brassica represents an important group of oilseed crops with a long history of evolution and cultivation. To understand the origin and evolution of Brassica amphidiploids, simple sequence repeat (SSR) markers were used to unravel genetic variations in three diploids and three amphidiploid Brassica species of U's triangle along with Eruca sativa as an outlier. RESULTS: Of 124 Brassica-derived SSR loci assayed, 100% cross-transferability was obtained for B...
2018: Hereditas
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