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Fukushima Journal of Medical Science

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https://www.readbyqxmd.com/read/30012939/prognostic-impact-of-preoperative-lymphocyte-to-monocyte-ratio-in-patients-with-colorectal-cancer-with-special-reference-to-myeloid-derived-suppressor-cells
#1
Tatsuo Shimura, Masahiko Shibata, Kenji Gonda, Suguru Hayase, Wataru Sakamoto, Hirokazu Okayama, Shotaro Fujita, Motonobu Saito, Tomoyuki Momma, Shinji Ohki, Koji Kono
AIMS: We aimed to investigate the relationship of colorectal cancer prognosis and inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), with reference to circulating myeloid-derived suppressor cells (MDSCs) in the current study. PATIENTS AND METHODS: Thirty-five patients who underwent curative-intent surgery were enrolled. A receiver-operating characteristic curve (ROC) was used to assess the usefulness of candidates for prognostic factors...
July 14, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30012938/comparisons-between-the-efficacy-of-limaprost-alfadex-and-pregabalin-in-cervical-spondylotic-radiculopathy-design-of-a-randomized-controlled-trial
#2
Akira Onda, Masashi Kimura
BACKGROUND: Cervical spondylotic radiculopathy (CSR) is a relatively common neurological disease caused by the mechanical compression of nerve roots. Limaprost, a prostaglandin E1 derivative, functions as a vasodilator and has been used in the treatment of lumbar spinal stenosis in Japan. However, the effects of limaprost in cervical radiculopathy remain unclear. Our aim was to compare the efficacy of limaprost with that of pregabalin, which is widely used for the treatment of neuropathic pain...
July 14, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30012937/feasibility-of-skin-acetone-analysis-in-patients-with-cardiovascular-diseases
#3
Tetsuro Yokokawa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Akiomi Yoshihisa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: Breath acetone is reported to be a noninvasive biomarker for heart failure. However, the measurement of this metabolite requires expertize and is not standardized yet. Acetone is also released from the skin; thus, measuring acetone as a skin gas may be easier than breath analysis. METHODS: We analyzed skin acetone collected from 41 hospitalized patients with cardiovascular diseases. Passive samplers were used to measure skin acetone emission. Passive sampler was softly fixed on the surface of forearm skin for 10 hour at night...
July 14, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29925726/methotrexate-associated-lymphoproliferative-disorder-complicated-by-severe-acute-respiratory-failure-and-ileal-perforation-a-case-report
#4
Eiji Suzuki, Takashi Kanno, Satoru Kimura, Takumi Irie, Hajime Odajima, Kiyoshi Migita
Lymphoproliferative disorder (LPD) is a potentially severe adverse effect of methotrexate (MTX) administration in patients with rheumatoid arthritis (RA). We report a case of MTX-associated LPD (MTX-LPD) in a patient with RA who developed severe pulmonary failure complicated by perforation of the terminal ileum. A 61-year-old woman with RA receiving MTX complained of dyspnea and abdominal pain. She was diagnosed with intestinal perforation and peritonitis, and underwent immediate abdominal surgery. Pathological examinations of the specimen obtained from the resected ileum and a bone marrow aspirate revealed diffuse large B-cell lymphoma...
June 19, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29780055/postoperative-neck-symptoms-of-posterior-approach-for-cervical-compressive-myelopathy-expansive-open-door-laminoplasty-vs-segmental-partial-laminectomy
#5
Koji Otani, Masumi Iwabuchi, Katsuhiko Sato, Shinichi Konno, Shinichi Kikuchi
BACKGROUND: Laminoplasty is widely accepted as a standard treatment of cervical compressive myelopathy. However, due to the risk of postoperative complications such as neck symptoms, segmental partial laminectomy (SPL) is performed instead, which results in fewer postoperative symptoms. The aim of this study was to describe the difference in the incidence and severity of postoperative neck symptoms between traditional C3-C7 expansive open-door laminoplasty (ELAP) and SPL. METHODS: A retrospective and comparative study was performed regarding neck complications following the two surgical procedures...
May 18, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29628468/induction-of-anti-pf4-heparin-antibodies-after-arthroplasty-for-rheumatic-diseases
#6
Kiyoshi Migita, Tomoyuki Asano, Shuzo Sato, Satoru Motokawa
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. These pathogenic antibodies against PF4/heparin bind and activate cellular FcγRIIa on platelets to induce a hypercoagulable state culminating in thrombosis. Recent studies indicate several conditions, including joint surgery, induce spontaneous HIT, which can occur without exposure to heparin. To determine the real-world evidences concerning the incidences of venous thromboembolism (VTE) after total joint arthroplasty for rheumatic disease, we conducted a multicenter cohort study (J-PSVT) designed to document the VTE and seroconversion rates of anti-PF4/heparin antibody in 34 Japanese National hospital organization (NHO) hospitals...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29628467/targeted-therapy-according-to-next-generation-sequencing-based-panel-sequencing
#7
Motonobu Saito, Tomoyuki Momma, Koji Kono
Targeted therapy against actionable gene mutations shows a significantly higher response rate as well as longer survival compared to conventional chemotherapy, and has become a standard therapy for many cancers. Recent progress in next-generation sequencing (NGS) has enabled to identify huge number of genetic aberrations. Based on sequencing results, patients recommend to undergo targeted therapy or immunotherapy. In cases where there are no available approved drugs for the genetic mutations detected in the patients, it is recommended to be facilitate the registration for the clinical trials...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29540624/surgical-outcomes-of-total-laparoscopic-hysterectomy-with-2-dimensional-versus-3-dimensional-laparoscopic-surgical-systems
#8
Hiroyuki Yazawa, Kaoru Takiguchi, Karin Imaizumi, Marina Wada, Fumihiro Ito
Three-dimensional (3D) laparoscopic surgical systems have been developed to account for the lack of depth perception, a known disadvantage of conventional 2-dimensional (2D) laparoscopy. In this study, we retrospectively compared the outcomes of total laparoscopic hysterectomy (TLH) with 3D versus conventional 2D laparoscopy. From November 2014, when we began using a 3D laparoscopic system at our hospital, to December 2015, 47 TLH procedures were performed using a 3D laparoscopic system (3D-TLH). The outcomes of 3D-TLH were compared with the outcomes of TLH using the conventional 2D laparoscopic system (2D-TLH) performed just before the introduction of the 3D system...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29459574/comparison-of-surgical-outcomes-after-pneumonectomy-and-pulmonary-function-preserving-surgery-for-non-small-cell-lung-cancer
#9
Mitsunori Higuchi, Hironori Takagi, Yuki Ozaki, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Yutaka Shio, Hiroyuki Suzuki
BACKGROUND: According to previous reports, lobectomy with bronchoplasty or angioplasty is a more feasible surgery than pneumonectomy for central-type non-small cell lung cancer. However, few studies have compared both the short- and long-term outcomes between pneumonectomy and pulmonary function-preserving surgery. METHODS: From January 2004 to December 2015, 18 patients underwent pneumonectomy (Group PN) and 12 patients underwent pulmonary function-preserving surgery (group PS) at Fukushima Medical University Hospital...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29398691/emotional-disturbance-assessed-by-the-self-rating-depression-scale-test-is-associated-with-mortality-among-japanese-hemodialysis-patients
#10
Sakumi Kazama, Junichiro James Kazama, Minako Wakasugi, Yumi Ito, Ichiei Narita, Motoko Tanaka, Fumi Horiguchi, Koichi Tanigawa
Emotional disturbance including depression is associated with increased mortality among dialysis patients. The Self-Rating Depression Scale (SDS) is a simple tool for assessing emotional disturbance. This study investigated the relationship between emotional conditions as assessed with the SDS test and mortality among 491 hemodialysis patients. At baseline, 183 (37.3%), 180 (36.7%), 108 (22.0%), and 20 (4.1%) were classified as normal, borderline depression, depression, and severe depression, respectively. During the two years of observation period, 57 of 491 (11...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29343655/spatiotemporal-alterations-of-autophagy-marker-lc3-in-rat-skin-fibroblasts-during-wound-healing-process
#11
Emiko Asai, Masaya Yamamoto, Kazuki Ueda, Satoshi Waguri
To investigate the possible implications of autophagy, one of the degradation pathways induced by metabolic stress, in the dynamic reconstructive process of wound healing, the appearance and changes of punctate structures for microtubule-associated protein 1 light chain 3 (LC3), an autophagosome marker, were examined in a rat skin wound healing model. Although the ratio of LC3-II/LC3-I in Western blotting was not evidently changed during the wound healing process, LC3-positive dots were clearly observed in fibroblasts and myofibroblasts, and occasionally in macrophages, by immunohistofluorescence microscopy...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29237989/the-characteristics-of-non-respondents-and-respondents-of-a-mental-health-survey-among-evacuees-in-a-disaster-the-fukushima-health-management-survey
#12
Naoko Horikoshi, Hajime Iwasa, Seiji Yasumura, Masaharu Maeda
The Fukushima Medical University conducted a mental health care program for evacuees after the Fukushima Daiichi nuclear power plant accident. However, the mental health status of non-respondents has not been considered for surveys using questionnaires. Therefore, the aim of this study was to clarify the characteristics of non-respondents and respondents. The target population of the survey (FY2011-2013) is people living in the nationally designated evacuation zone of Fukushima prefecture. Among these, the participants were 967 people (20 years or older)...
December 19, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29199261/tbx19-is-overexpressed-in-colorectal-cancer-and-associated-with-lymph-node-metastasis
#13
Jin Ando, Motonobu Saito, Jun-Ichi Imai, Emi Ito, Yuka Yanagisawa, Reiko Honma, Katsuharu Saito, Kazunoshin Tachibana, Tomoyuki Momma, Shinji Ohki, Tohru Ohtake, Shinya Watanabe, Satoshi Waguri, Koji Kono, Seiichi Takenoshita
The T-box 19 (TBX19) gene encodes a transcription factor characterized by a highly conserved DNA-binding motif (T-box). Recent studies have revealed that TBX19 has been identified as one of the genes activated by KRAS mutations, and is upregulated in colon adenoma. These results indicate that TBX19 may work as an oncogene in colorectal cancer (CRC). However, the expression and role of TBX19 have yet to be investigated. Here, we investigated TBX19 mRNA and protein expressions in colon cancer cells or surgically resected CRC...
December 19, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29142151/two-cases-of-liver-cirrhosis-treated-with-lusutrombopag-before-partial-splenic-embolization
#14
Masashi Fujita, Kazumichi Abe, Manabu Hayashi, Ken Okai, Atsushi Takahashi, Hiromasa Ohira
Lusutrombopag, a small molecule thrombopoietin receptor agonist, has been approved for the treatment of chronic liver disease-associated thrombocytopenia due to hypersplenism in patients scheduled to undergo elective invasive procedures in Japan. We performed partial splenic embolization (PSE) after administration of lusutrombopag in two patients with thrombocytopenia due to cirrhosis. Case 1 involved a 50-year-old man who developed cirrhosis due to hepatitis B virus (HBV) infection and alcohol consumption...
December 19, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28904302/the-incidence-and-severity-of-iga-vasculitis-with-nephritis-over-a-10-year-period-in-our-hospital
#15
Keishi Yamane, Yukihiko Kawasaki, Ryo Maeda, Shinichiro Ohara, Kazuhide Suyama, Mitsuaki Hosoya
BACKGROUND: To evaluate the recent frequency of onset and severity of IgA vasculitis with nephritis (IgAVN) in Fukushima Prefecture, we examined the epidemiology and clinico-pathological manifestations of IgAVN in our hospital over a 10-year period. METHODS: We enrolled 18 patients with IgAVN treated between 2004 and 2013 in the Department of Pediatrics, Fukushima Medical University School of Medicine. These patients were divided into two groups; Group 1 consisted of 12 patients with IgAVN hospitalized between 2004 and 2008 and Group 2 consisted of 6 patients with IgAVN hospitalized between 2009 and 2013...
December 19, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28904301/a-case-of-gastric-lipoma-resected-by-endoscopic-submucosa-dissection-with-difficulty-in-preoperative-diagnosis
#16
Mizue Ichinose, Takuto Hikichi, Yukiko Kanno, Naohiko Gunji, Masashi Fujita, Masahito Kuroda, Kumiko Terashima, Yoshinori Sato, Satoshi Kawana, Yuko Hashimoto, Hiromasa Ohira, Masayuki Miyata
A 66-year-old man was referred to our hospital with an increasing subepithelial lesion in the gastric antrum. Using esophagogastroduodenoscopy, a tumor with a steep, 20-mm-high rise protruding in the lumen was observed. The mucosal surface of the tumor was reddish, with ulcers forming at the base. Moreover, the tumor was mobile and soft. A biopsy specimen was taken from the ulcer, but tumor tissue was not collected from the submucosa. Endoscopic ultrasonography (EUS) showed a high echoic mass in the submucosa...
December 19, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28867684/neutralizing-epitopes-of-rsv-and-palivizumab-resistance-in-japan
#17
Koichi Hashimoto, Mitsuaki Hosoya
Respiratory Syncytial Virus (RSV) is one of the most important viral pathogen related to acute lower respiratory infection in young children. The virus surface envelope contains the G, F, and SH proteins as spike proteins. The F protein is considered to be a major antigenic target for the neutralizing (NT) epitope as only the F protein is essential for cell infection among the three viral envelope proteins, and it is more highly conserved than the G protein. Recently, four antigenic targets related to NT activity have been reported;site I, site II, site IV, and site zero (0)...
December 19, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28747618/comprehensive-approach-for-post-prostatectomy-incontinence-in-the-era-of-robot-assisted-radical-prostatectomy
#18
REVIEW
Nobuhiro Haga, Ruriko Takinami, Ryo Tanji, Akifumi Onagi, Kanako Matsuoka, Tomoyuki Koguchi, Hidenori Akaihata, Junya Hata, Soichiro Ogawa, Masao Kataoka, Yuichi Sato, Kei Ishibashi, Ken Aikawa, Yoshiyuki Kojima
Robot-assisted radical prostatectomy (RARP) has enabled steady and stable surgical procedures due to both meticulous maneuvers and magnified, clear, 3-dimensional vision. Therefore, better surgical outcomes have been expected with RARP than with other surgical modalities. However, even in the RARP era, post-prostatectomy incontinence has a relatively high incidence as a bothersome complication. To overcome post-prostatectomy incontinence, it goes without saying that meticulous surgical procedures and creative surgical procedures, i...
August 9, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28747617/prolonged-infection-at-the-tibial-bone-tunnel-after-anterior-cruciate-ligament-reconstruction
#19
Hironori Numazaki, Hideo Kobayashi, Katsuhiro Yoshida, Michiyuki Hakozaki, Shin-Ichi Konno
A 24-year-old man with severe atopic dermatitis underwent anterior cruciate ligament (ACL) reconstruction of the right knee seven years earlier but developed a surgical site infection. The infection did not heal after removal of the metal implants, and a fistula eventually developed. This condition was left untreated for six years before he was referred to our hospital. Magnetic resonance imaging showed fluid in the tibial bone tunnel and extensive bone marrow edema surrounding the bone tunnel. Based on these findings, abscess formation within the tibial bone tunnel and osteomyelitis spreading to the proximal tibia were suspected...
August 9, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28747616/assessment-of-non-invasive-chronic-fungal-rhinosinusitis-by-cone-beam-ct-comparison-with-multidetector-ct-findings
#20
COMPARATIVE STUDY
Tomohiko Yamauchi, Akiko Tani, Shuji Yokoyama, Hiroshi Ogawa
OBJECTIVE: To investigate the accuracy of cone beam CT (CBCT) to diagnose non-invasive chronic fungal rhinosinusitis. METHODS: Preoperative CT evaluation of non-invasive chronic fungal rhinosinusitis was performed by CBCT (3D Accuitomo 170® ) and traditional multidetector CT (MDCT) (Aquilion 32® ) in 13 and 38 patients with non-invasive chronic fungal maxillary sinusitis, respectively, in different facilities. Detection of intrasinus calcification was compared between these two groups...
August 9, 2017: Fukushima Journal of Medical Science
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