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Fukushima Journal of Medical Science

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https://www.readbyqxmd.com/read/30404951/safety-and-effectiveness-of-transcatheter-closure-of-atrial-septal-defects-initial-results-in-fukushima-prefecture
#1
Atsushi Kobayashi, Hiroyuki Kunii, Tetsuro Yokokawa, Yuya Sakuma, Masayoshi Oikawa, Akiomi Yoshihisa, Takayoshi Yamaki, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: Atrial septal defect is the third most common type of congenital heart disease. Surgical closure was the standard treatment for atrial septal defects before transcatheter closure was approved as minimally invasive treatment in Japan in 2006. In our hospital, this procedure has been performed since 2015. OBJECTIVE: To evaluate the safety and effectiveness of transcatheter closure of atrial septal defects in our hospital. METHODS: Thirty patients (mean age 57...
November 6, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30369521/fukushima-journal-of-medical-science-original-articles-re-revised-manuscript-no-2018-05-predictive-factors-for-poor-outcome-in-pediatric-c3-glomerulonephritis
#2
Mamiko Hosoya, Yukihiko Kawasaki, Ryo Maeda, Masatoki Sato, Kazuhide Suyama, Koichi Hashimoto, Mitsuaki Hosoya
BACKGROUND: To clarify the predictive factors for poor outcome in pediatric C3 glomerulonephritis (C3GN), we retrospectively evaluated the relationship between the clinico-pathological findings and prognosis in cases of pediatric C3GN. METHODS: We enrolled 18 patients diagnosed with C3GN. These patients were divided into two groups, four patients in the end-stage renal disease (ESRD) group and 14 patients in non-ESRD group, based on clinical status at the last examination...
October 27, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30369518/interleukin-6-induces-drug-resistance-in-renal-cell-carcinoma
#3
Kei Ishibashi, Tomoyuki Koguchi, Kanako Matsuoka, Akifumi Onagi, Ryo Tanji, Ruriko Takinami-Honda, Seiji Hoshi, Mitsutaka Onoda, Yoshimasa Kurimura, Junya Hata, Yuichi Sato, Masao Kataoka, Soichiro Ogawsa, Nobuhiro Haga, Yoshiyuki Kojima
Metastatic renal cell carcinoma (mRCC) is a tumor entity with poor prognosis due to limited therapy options. Tyrosine kinase inhibitors (TKIs), the novel targeted agents have been used for the treatment of mRCC and have shown efficacy. Interferon (IFN)-α is also one of the most frequently used agents in immunotherapy. However, drug resistance needs to be overcome to achieve a sufficiently positive effect. Interleukin-6 (IL-6), which induce suppressor of cytokine signaling-3 (SOCS3) expression, is one of the factors associated with poor prognosis of patients with renal cell carcinoma (RCC)...
October 23, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30344206/propofol-is-a-more-effective-and-safer-sedative-agent-than-midazolam-in-endoscopic-injection-sclerotherapy-for-esophageal-varices-in-patients-with-liver-cirrhosis-a-randomized-controlled-trial
#4
Ko Watanabe, Takuto Hikichi, Tadayuki Takagi, Rei Suzuki, Jun Nakamura, Mitsuru Sugimoto, Hitomi Kikuchi, Naoki Konno, Mika Takasumi, Yuki Sato, Minami Hashimoto, Hiroki Irie, Katsutoshi Obara, Hiromasa Ohira
OBJECTIVE: The efficacy of sedation during endoscopic injection sclerotherapy (EIS) for esophageal varices (EVs) in patients with liver cirrhosis remains unclear. The aim of this study is to compare the efficacy and safety between propofol- and midazolam-based sedation for EIS. METHODS: Twenty-three patients with EVs were prospectively and randomly assigned to midazolam-based (Midazolam group) or propofol-based (Propofol group) sedation. All patients underwent a number connection test (NCT) to evaluate minimal hepatic encephalopathy (MHE) on the day before and at 2 and 24 hours following EIS...
October 21, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30344205/molecular-mechanisms-and-clinical-features-of-heart-failure
#5
Satoshi Suzuki, Yasuchika Takeishi
Heart failure (HF) is a common disease with high prevalence, mortality in hospitalization and after discharge, readmission rates, and burden on healthcare system. Activation of the inflammatory systems is an important role for HF progression, and pentraxin 3 (PTX3) is one of the inflammatory markers. The plasma PTX3 levels increased with advancing the HF severity, and high levels of plasma PTX3 indicated poor prognosis in HF patients. Moreover, we demonstrated that PTX3 had the crucial role for cardiac remodeling under pressure overload using two different genotypes of mice: PTX3 systemic knockout mice and transgenic mice with cardiac-specific overexpression of PTX3...
October 21, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30197399/endoscopic-ultrasound-guided-fine-needle-aspiration-for-pancreatic-cancer
#6
Rei Suzuki, Tadayuki Takagi, Mitsuru Sugimoto, Naoki Konno, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Mika Takasumi, Minami Hashimoto, Takuto Hikichi, Hiromasa Ohira
Since the development of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in the early 1990s, its application has been extended to various diseases. For pancreatic cancer (PC), EUS-FNA can obtain specimens from the tumor itself with fewer complications than other methods. EUS-FNA can also be more useful for TNM staging than other imaging modalities. Furthermore, EUS-FNA can contribute to precision medicine by obtaining tissue for immunohistochemical or genetic studies from primary or metastatic sites of diseases...
September 8, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30197398/delayed-perforation-after-endoscopic-submucosal-dissection-for-mucosal-colon-cancer-a-conservatively-treated-case
#7
Kazumasa Kawashima, Takuto Hikichi, Tatsuo Fujiwara, Naohiko Gunji, Jun Nakamura, Ko Watanabe, Kyoko Katakura, Hiromasa Ohira
A 66-year-old man was diagnosed from colonoscopy as having a 40-mm elevated tumor in the cecum. With a preoperative diagnosis of intramucosal carcinoma, endoscopic submucosal dissection (ESD) was performed. The tumor was resected en bloc, yielding a specimen with a 66-mm diameter. No perforation was detected during the operation.Although neither abdominal pain nor fever was observed immediately after ESD, abdominal pain developed on the following day. Two days after ESD, the abdominal pain ceased. The patient was managed conservatively with fasting and intravenous antibiotic treatment...
September 8, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30058598/immunotherapy-for-esophageal-squamous-cell-carcinoma-a-review
#8
Kosaku Mimura, Leo Yamada, Daisuke Ujiie, Suguru Hayase, Takeshi Tada, Hiroyuki Hanayama, Aung Kyi Thar Min, Masahiko Shibata, Tomoyuki Momma, Zenichiro Saze, Shinji Ohki, Koji Kono
Cancer vaccines and immune checkpoint inhibitors (ICI) have recently been employed as immunotherapies for esophageal squamous cell carcinoma (ESCC). Cancer vaccines for ESCC have yielded several promising results from investigator-initiated phase I and II clinical trials. Furthermore, a Randomized Controlled Trial as an adjuvant setting after curative surgery is in progress in Japan. On the other hand, ICI, anti-CTLA-4 mAb and anti-PD-1 mAb, have demonstrated tumor shrinkage and improved overall survival in patients with multiple cancer types...
August 29, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30012939/prognostic-impact-of-preoperative-lymphocyte-to-monocyte-ratio-in-patients-with-colorectal-cancer-with-special-reference-to-myeloid-derived-suppressor-cells
#9
Tatsuo Shimura, Masahiko Shibata, Kenji Gonda, Suguru Hayase, Wataru Sakamoto, Hirokazu Okayama, Shotaro Fujita, Motonobu Saito, Tomoyuki Momma, Shinji Ohki, Koji Kono
AIMS: We aimed to investigate the relationship of colorectal cancer prognosis and inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), with reference to circulating myeloid-derived suppressor cells (MDSCs) in the current study. PATIENTS AND METHODS: Thirty-five patients who underwent curative-intent surgery were enrolled. A receiver-operating characteristic curve (ROC) was used to assess the usefulness of candidates for prognostic factors...
August 29, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30012938/comparisons-between-the-efficacy-of-limaprost-alfadex-and-pregabalin-in-cervical-spondylotic-radiculopathy-design-of-a-randomized-controlled-trial
#10
Akira Onda, Masashi Kimura
BACKGROUND: Cervical spondylotic radiculopathy (CSR) is a relatively common neurological disease caused by the mechanical compression of nerve roots. Limaprost, a prostaglandin E1 derivative, functions as a vasodilator and has been used in the treatment of lumbar spinal stenosis in Japan. However, the effects of limaprost in cervical radiculopathy remain unclear. Our aim was to compare the efficacy of limaprost with that of pregabalin, which is widely used for the treatment of neuropathic pain...
August 29, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30012937/feasibility-of-skin-acetone-analysis-in-patients-with-cardiovascular-diseases
#11
Tetsuro Yokokawa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Akiomi Yoshihisa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: Breath acetone is reported to be a noninvasive biomarker for heart failure. However, the measurement of this metabolite requires expertize and is not standardized yet. Acetone is also released from the skin; thus, measuring acetone as a skin gas may be easier than breath analysis. METHODS: We analyzed skin acetone collected from 41 hospitalized patients with cardiovascular diseases. Passive samplers were used to measure skin acetone emission. Passive sampler was softly fixed on the surface of forearm skin for 10 hour at night...
August 29, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29925726/methotrexate-associated-lymphoproliferative-disorder-complicated-by-severe-acute-respiratory-failure-and-ileal-perforation-a-case-report
#12
Eiji Suzuki, Takashi Kanno, Satoru Kimura, Takumi Irie, Hajime Odajima, Kiyoshi Migita
Lymphoproliferative disorder (LPD) is a potentially severe adverse effect of methotrexate (MTX) administration in patients with rheumatoid arthritis (RA). We report a case of MTX-associated LPD (MTX-LPD) in a patient with RA who developed severe pulmonary failure complicated by perforation of the terminal ileum. A 61-year-old woman with RA receiving MTX complained of dyspnea and abdominal pain. She was diagnosed with intestinal perforation and peritonitis, and underwent immediate abdominal surgery. Pathological examinations of the specimen obtained from the resected ileum and a bone marrow aspirate revealed diffuse large B-cell lymphoma...
August 29, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29780055/postoperative-neck-symptoms-of-posterior-approach-for-cervical-compressive-myelopathy-expansive-open-door-laminoplasty-vs-segmental-partial-laminectomy
#13
Koji Otani, Masumi Iwabuchi, Katsuhiko Sato, Shinichi Konno, Shinichi Kikuchi
BACKGROUND: Laminoplasty is widely accepted as a standard treatment of cervical compressive myelopathy. However, due to the risk of postoperative complications such as neck symptoms, segmental partial laminectomy (SPL) is performed instead, which results in fewer postoperative symptoms. The aim of this study was to describe the difference in the incidence and severity of postoperative neck symptoms between traditional C3-C7 expansive open-door laminoplasty (ELAP) and SPL. METHODS: A retrospective and comparative study was performed regarding neck complications following the two surgical procedures...
August 29, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29628468/induction-of-anti-pf4-heparin-antibodies-after-arthroplasty-for-rheumatic-diseases
#14
REVIEW
Kiyoshi Migita, Tomoyuki Asano, Shuzo Sato, Satoru Motokawa
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. These pathogenic antibodies against PF4/heparin bind and activate cellular FcγRIIa on platelets to induce a hypercoagulable state culminating in thrombosis. Recent studies indicate several conditions, including joint surgery, induce spontaneous HIT, which can occur without exposure to heparin. To determine the real-world evidences concerning the incidences of venous thromboembolism (VTE) after total joint arthroplasty for rheumatic disease, we conducted a multicenter cohort study (J-PSVT) designed to document the VTE and seroconversion rates of anti-PF4/heparin antibody in 34 Japanese National hospital organization (NHO) hospitals...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29628467/targeted-therapy-according-to-next-generation-sequencing-based-panel-sequencing
#15
Motonobu Saito, Tomoyuki Momma, Koji Kono
Targeted therapy against actionable gene mutations shows a significantly higher response rate as well as longer survival compared to conventional chemotherapy, and has become a standard therapy for many cancers. Recent progress in next-generation sequencing (NGS) has enabled to identify huge number of genetic aberrations. Based on sequencing results, patients recommend to undergo targeted therapy or immunotherapy. In cases where there are no available approved drugs for the genetic mutations detected in the patients, it is recommended to be facilitate the registration for the clinical trials...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29540624/surgical-outcomes-of-total-laparoscopic-hysterectomy-with-2-dimensional-versus-3-dimensional-laparoscopic-surgical-systems
#16
Hiroyuki Yazawa, Kaoru Takiguchi, Karin Imaizumi, Marina Wada, Fumihiro Ito
Three-dimensional (3D) laparoscopic surgical systems have been developed to account for the lack of depth perception, a known disadvantage of conventional 2-dimensional (2D) laparoscopy. In this study, we retrospectively compared the outcomes of total laparoscopic hysterectomy (TLH) with 3D versus conventional 2D laparoscopy. From November 2014, when we began using a 3D laparoscopic system at our hospital, to December 2015, 47 TLH procedures were performed using a 3D laparoscopic system (3D-TLH). The outcomes of 3D-TLH were compared with the outcomes of TLH using the conventional 2D laparoscopic system (2D-TLH) performed just before the introduction of the 3D system...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29459574/comparison-of-surgical-outcomes-after-pneumonectomy-and-pulmonary-function-preserving-surgery-for-non-small-cell-lung-cancer
#17
COMPARATIVE STUDY
Mitsunori Higuchi, Hironori Takagi, Yuki Ozaki, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Yutaka Shio, Hiroyuki Suzuki
BACKGROUND: According to previous reports, lobectomy with bronchoplasty or angioplasty is a more feasible surgery than pneumonectomy for central-type non-small cell lung cancer. However, few studies have compared both the short- and long-term outcomes between pneumonectomy and pulmonary function-preserving surgery. METHODS: From January 2004 to December 2015, 18 patients underwent pneumonectomy (Group PN) and 12 patients underwent pulmonary function-preserving surgery (group PS) at Fukushima Medical University Hospital...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29398691/emotional-disturbance-assessed-by-the-self-rating-depression-scale-test-is-associated-with-mortality-among-japanese-hemodialysis-patients
#18
Sakumi Kazama, Junichiro James Kazama, Minako Wakasugi, Yumi Ito, Ichiei Narita, Motoko Tanaka, Fumi Horiguchi, Koichi Tanigawa
Emotional disturbance including depression is associated with increased mortality among dialysis patients. The Self-Rating Depression Scale (SDS) is a simple tool for assessing emotional disturbance. This study investigated the relationship between emotional conditions as assessed with the SDS test and mortality among 491 hemodialysis patients. At baseline, 183 (37.3%), 180 (36.7%), 108 (22.0%), and 20 (4.1%) were classified as normal, borderline depression, depression, and severe depression, respectively. During the two years of observation period, 57 of 491 (11...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/29343655/spatiotemporal-alterations-of-autophagy-marker-lc3-in-rat-skin-fibroblasts-during-wound-healing-process
#19
Emiko Asai, Masaya Yamamoto, Kazuki Ueda, Satoshi Waguri
To investigate the possible implications of autophagy, one of the degradation pathways induced by metabolic stress, in the dynamic reconstructive process of wound healing, the appearance and changes of punctate structures for microtubule-associated protein 1 light chain 3 (LC3), an autophagosome marker, were examined in a rat skin wound healing model. Although the ratio of LC3-II/LC3-I in Western blotting was not evidently changed during the wound healing process, LC3-positive dots were clearly observed in fibroblasts and myofibroblasts, and occasionally in macrophages, by immunohistofluorescence microscopy...
April 17, 2018: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/30158336/acute-peri-myocarditis-with-an-unusual-initial-manifestation-of-gallbladder-edema-and-a-profound-eosinophilic-surge-during-convalescence
#20
Takahiro Zenda, Ichiro Araki, Otoyuki Nakamiya, Mitsuko Ogawa, Kotaro Higashi, Toshio Ueno
A 29-year-old man with fever and right upper quadrant pain was referred to our hospital. Ultrasonography revealed intense gallbladder edema and pericardial effusion. Despite no symptoms and signs related to heart failure, the patient was clinically suspected of cardiac dysfunction related to acute peri-myocarditis based on his symptoms of preceding fever and headache, pericardial effusion, positive troponin T value, elevated B-type natriuretic peptide level, and sequential changes on electrocardiography. With a profound eosinophilic surge (8,022/µL) during convalescence, acute peri-myocarditis and gallbladder edema resolved spontaneously...
2018: Fukushima Journal of Medical Science
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