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Fukushima Journal of Medical Science

Ryoma Suzuki, Kyoko Katakura, Tatsuo Fujiwara, Naohiko Gunji, Hiroshi Watanabe, Hiromasa Ohira
To investigate whether Imiquimod (IMQ) as TLR7 ligand protects mice from colonic inflammation and the mechanisms underlying in such immunoregulatory conditions. METHODS: Murine colitis was induced to Balb/c mice by administration of trinitrobenzene sulfonic acid (TNBS) with or without daily intraperitoneal administration of IMQ. Colitis was evaluated by body weight decreases and by histological score. Also colonic mRNA expression was measured by RT-PCR. To confirm the induction of Regulatory T cells (Tregs) by type-1 IFN from pDCs, we generated mouse bone marrow-derived pDCs and co-cultured these with CD4(+) T cells isolated from mouse spleen with or without IMQ stimulation...
December 16, 2016: Fukushima Journal of Medical Science
Toshihiko Nakamura, Daisuke Hatanaka, Mari Nakamura, Michiko Kusakari, Hidehiro Takahashi, Takashi Kamohara
Transient late-onset hyperglycemia was detected in a very low birth weight (VLBW) infant (gestational age 28 weeks, birth weight 1,082 g) by routine point-of-care glucose monitoring. The infant had no clinical symptom. Serial continuous glucose monitoring (CGM) was conducted for 3 days at 31, 35, and 39 weeks' post conceptual age. The difference values between the maximum and minimum blood glucose levels during the interval from one enteral feeding to the next enteral feeding were 32.3±14.3 mg/dL, 47...
December 16, 2016: Fukushima Journal of Medical Science
Ryoichi Kawakami, Soichi Ejiri, Michiyuki Hakozaki, Satoshi Hatashita, Nobuyuki Sasaki, Yoshitaka Kobayashi, Yoko Takahashi, Shin-Ichi Konno
BACKGROUND: The treatment of septic non-union of the tibia is a challenging area. The objective of this clinical study was to improve the treatment outcomes in patients with a highly active infection by the three strategies consisting of a two-staged operation, a flow-through technique for vascular anastomosis of a free vascularized fibular graft (FVFG), and continuous local intra-arterial infusion of heparin. PATIENTS & METHOD: Five patients with septic non-union of the tibia who were treated with an FVFG (mean age: 52...
December 16, 2016: Fukushima Journal of Medical Science
Taisuke Otani, Noriyuki Isohata, Kensuke Kumamoto, Shungo Endo, Kenichi Utano, Daiki Nemoto, Masato Aizawa, Alan K Lefor, Kazutomo Togashi
During the 1990s, laparoscopic resection was established as a treatment for gastrointestinal malignant tumors. A number of randomized controlled trials comparing laparoscopic-assisted colorectal surgery with conventional open colorectal surgery for colon cancer have been conducted. These trials have shown short-term benefits, and the vast majority demonstrated no significant difference in long-term outcomes. Laparoscopic-assisted colorectal surgery is widely performed for the treatment of colon cancer, whereas laparoscopic-assisted colorectal surgery for rectal cancer is less commonly performed...
December 16, 2016: Fukushima Journal of Medical Science
Ko Watanabe, Takuto Hikichi, Jun Nakamura, Tadayuki Takagi, Rei Suzuki, Mitsuru Sugimoto, Yuichi Waragai, Hitomi Kikuchi, Naoki Konno, Hiroyuki Asama, Mika Takasumi, Hiroshi Watanabe, Katsutoshi Obara, Hiromasa Ohira
A 58-year-old man with liver cirrhosis and renal failure was diagnosed with esophageal varices (EVs) and a gastric cardia varix (GCV) by esophagogastroduodenoscopy (EGD). The patient also exhibited early gastric cancer (EGC) in the upper gastric body adjacent to the GCV. The EVs and GCV were treated using endoscopy before endoscopic submucosal dissection (ESD) of the EGC to prevent variceal bleeding during ESD. Endoscopic variceal ligation (EVL) was performed to treat the EVs. In addition, extra-variceal polidocanol injection and argon plasma coagulation (APC) were performed after EVL...
December 16, 2016: Fukushima Journal of Medical Science
Nobuko Sakai, Yukihiko Kawasaki, Tomoko Waragai, Tomoko Oikawa, Masatoshi Kaneko, Tomoko Sato, Kazuhide Suyama, Mitsuaki Hosoya
Immunoglobulin A nephropathy (IgAN) is the most common form of chronic glomerulonephritis worldwide. In Japan, the treatment for use as an initial therapy was established in Guidelines for the Treatment of Childhood IgA nephropathy; however, no rescue therapy for recurrent or steroid-resistant pediatric IgAN was established. We report here a 15-year-old boy with severe IgAN, who was treated with combination therapy involving prednisolone, mizoribine, warfarin, and dilazep dihydrochloride for 2 years. The response to the combination therapy was good and both proteinuria and hematuria disappeared...
June 8, 2016: Fukushima Journal of Medical Science
Yuhko Suzuki, Taku Sato, Jun Sakuma, Masahiro Ichikawa, Yugo Kishida, Keiko Oda, Yoichi Watanabe, Takeshi Goto, Masahiro Sato, Kenneth E Nollet, Kiyoshi Saito, Hitoshi Ohto
We conducted a case series study to assess intracerebral hemorrhage (ICH) in the context of anti-platelets agents (APAs) and platelet (PLT) transfusion in Fukushima Prefecture.This study included patients who were newly diagnosed with ICH between January 2008 and June 2014 in the neurosurgical hospitals of Fukushima Prefecture. Four of ten neurosurgical hospitals responded to our questionnaire. Of 287 ICH patients, 51 (20.6%) were on APA therapy, of whom PLT transfusion was given to only one persistently bleeding patient who was on dual anti-platelet therapy...
June 8, 2016: Fukushima Journal of Medical Science
Noriko Abe, Tohru Ohtake, Katsuharu Saito, Kensuke Kumamoto, Takashi Sugino, Seiichi Takenoshita
To elucidate the association between the lymphangiogenesis and clinicopathological factors including the survival in breast cancer, 91 Japanese patients with breast cancer were investigated. The lymphangiogenesis was evaluated by the count of lymph vessel density (LVD) with immunohistochemical method using D2-40 monoclonal antibody, a specific marker for lymphatic endothelial cells.D2-40-positive lymph vessels were detected in 87 of 91 cases, and were mainly distributed in the peritumoral lesions or around the tumor edge...
June 8, 2016: Fukushima Journal of Medical Science
Takuto Hikichi, Masahiro Yamasaki, Ko Watanabe, Jun Nakamura, Masaki Sato, Tadayuki Takagi, Rei Suzuki, Mitsuru Sugimoto, Hitomi Kikuchi, Naoki Konno, Yuichi Waragai, Hiroyuki Asama, Mika Takasumi, Yutaka Ejiri, Hiroshi Watanabe, Hiromasa Ohira, Katsutoshi Obara
AIM: To investigate the feasibility of endoscopic submucosal dissection (ESD) using sodium carboxymethylcellulose (SCMC) for gastric cancer. METHODS: During October 2011 through April 2013, 98 lesions from 98 patients who underwent ESD using SCMC (ESD-SCMC) for early gastric cancer were enrolled in this study. Two endoscopists, who had each performed fewer than 30 ESD procedures (less-experienced ESD physicians), performed ESD-SCMC under the supervision of two experts...
June 8, 2016: Fukushima Journal of Medical Science
Kinshi Kato, Shoji Yabuki, Koji Otani, Takuya Nikaido, Ken-Ichi Otoshi, Kazuyuki Watanabe, Shin-Ichi Kikuchi, Shin-Ichi Konno
Symptomatic thoracic disc herniation is clinically rare. There are few cases of disc herniation of the thoracic spine in top athletes described in the literature. We herein present a rare case of chest wall pain due to thoracic disc herniation in a professional baseball pitcher. A 30-year-old, left-handed pitcher complained of left-sided chest wall pain in the region of his lower ribs during a game. Neurological examination revealed hypoesthesia of the left side of the chest at the level of the lower thoracic spine...
June 8, 2016: Fukushima Journal of Medical Science
Tetsuo Koshizuka, Ken Ishioka, Takahiro Kobayashi, Kazufumi Ikuta, Tatsuo Suzutani
UNLABELLED: The UL41 gene of herpes simplex virus type 1 (HSV-1) encodes a virion host shut off protein which is involved in immune evasion. The growth and virulence of HSV-1 is markedly reduced by the deletion of UL41. In this report, the UL41-deleted recombinant HSV-1 strain VR∆41 was evaluated as a prophylactic live attenuated vaccine against lethal HSV-1 infection in a mouse model. Intraperitoneal (i.p.) inoculation with the VR∆41 strain clearly inhibited lethal wild-type HSV-1 (VR-3 strain) infection after both i...
June 8, 2016: Fukushima Journal of Medical Science
Libing Li, Isao Matsuoka, Kazuho Sakamoto, Junko Kimura
We compared the effects of lysophosphatidylcholine (LPC) and acetylcholine (ACh) on IK(ACh), ICa and a non-selective cation current (INSC) in guinea-pig atrial myocytes to clarify whether LPC and ACh activate similar Gi/o-coupled effector systems. IK(ACh), ICa and INSC were analyzed in single atrial myocytes by the whole cell patch-clamp. LPC induced INSC in a concentration-dependent manner in atrial cells. ACh activated IK(ACh), but failed to evoke INSC. LPC also activated IK(ACh) but with significantly less potency than ACh...
June 8, 2016: Fukushima Journal of Medical Science
Mitsuko Fukasaku, Junko Kimura, Osamu Yamaguchi
Using the perforated patch voltage clamp, we investigated swelling-activated ionic channels (SACs) in rat urinary bladder smooth muscle cells. Hypo-osmotic (60%) bath solution increased a membrane current which was inhibited by the SAC inhibitor, gadolinium. The reversal potential of the hypotonicity-induced current shifted in the positive direction by increasing external K(+) concentration. The hypotonicity-induced current was inhibited by extracellular acidic pH, phorbol ester and forskolin. These pharmacological properties are identical to those of arachidonic acid-induced current present in these cells, suggesting the presence of TREK-1, a four-transmembrane two pore domain K(+) channel...
June 8, 2016: Fukushima Journal of Medical Science
Yasutaka Omori, Hiroaki Wakamatsu, Atsuyuki Sorimachi, Tetsuo Ishikawa
This study was conducted on the Fukushima Medical University (FMU) premises (in Fukushima City, Fukushima Prefecture) about four years after the Fukushima Daiichi Nuclear Power Plant accident. Its objectives were (1) to create a map of the ambient gamma dose rate (air-kerma rate) distribution, (2) to evaluate the air-kerma rate originating from natural radionuclides, and (3) to investigate the effects of snow cover on changes in the air-kerma rate. This man-borne survey revealed that the air-kerma rate varies widely, ranging from 0...
June 8, 2016: Fukushima Journal of Medical Science
Toshiyuki Yamamoto, Yasuhiro Hashimoto, Masayuki Yoshida, Kikuo Ohno, Hitoshi Ohto, Masafumi Abe
BACKGROUNDS: On March 11(th) 2011, the Tohoku region of Japan was struck by catastrophic disasters. Thousands of people were killed due to a magnitude 9.0 earthquake and its subsequent tsunami. Furthermore, a serious nuclear crisis occurred in Fukushima Prefecture as a result of the disasters, and an emergency evacuation was ordered to people living near the nuclear power plants. There was a lot of anxiety regarding lost families as well as the influences of radioactivity on the health of people and their children...
2015: Fukushima Journal of Medical Science
Toshihiko Nakamura, Tomoaki Nomura, Takashi Kamohara, Hidehiro Takahashi, Daisuke Hatanaka, Michiko Kusakari, Mari Nakamura, Kinuyo Kawabata, Hitoshi Ohto
Anti-HLA antibodies reportedly exist in the one third of pregnant women. But few occurrences of neonatal alloimmune thrombocytopenia (NAIT) caused by anti-HLA antibodies have been reported. Here a male baby, who was admitted for low birth weight with Down syndrome (DS), was suffered from thrombocytopenia without transient myeloproliferative disorder (TMD). Positive reactions of HLA-specific antibodies were detected in maternal serum. Cross-matching tests between maternal serum and paternal platelets and lymphocytes were strongly positive...
2015: Fukushima Journal of Medical Science
Hitomi Kikuchi, Takuto Hikichi, Tadayuki Takagi, Rei Suzuki, K O Watanabe, Jun Nakamura, Mitsuru Sugimoto, Yuichi Waragai, Naoki Konno, Hiroyuki Asama, Mika Takasumi, Hiroshi Watanabe, Katsutoshi Obara, Hiromasa Ohira
AIM: Peppermint oil, which suppresses gastric peristalsis during esophagogastroduodenoscopy (EGD), is effective for determining the margin of a gastric tumor. This study was conducted to evaluate the utility of an L-menthol preparation for suppressing gastric peristalsis and for diagnosing gastric tumors. METHODS: The study examined 124 patients who underwent EGD between January and April 2012. After 20 mL of 0.8% L-menthol was sprayed directly onto the mucosal surface of the gastric antrum, the degree of peristalsis suppression in the antrum was evaluated...
2015: Fukushima Journal of Medical Science
Ryoichi Kawakami, Shin-Ichi Konno, Soichi Ejiri, Satoshi Hatashita
BACKGROUND: Treatment strategies for bone defects include free bone grafting, distraction osteogenesis, and vascularized bone grafting. Because bone defect morphology is often irregular, selecting treatment strategies may be difficult. With the Masquelet technique, a fracture site is bridged and fixed with a locking plate after treating deep infection with antibiotic-containing cement, and a free cancellous bone-graft is concomitantly placed into the defects. This procedure avoids excessive bone resection...
2015: Fukushima Journal of Medical Science
Teruna Ito, Masayoshi Tsuji, Yayoi Mori, Hideyuki Kanda, Tomoo Hidaka, Takeyasu Kakamu, Tomohiro Kumagai, Takehito Hayakawa, Yoneatsu Osaki, And Tetsuhito Fukushima
OBJECTIVES: Nicotine in cigarettes is metabolized primarily by CYP2A6-catalyzed oxidation. The CYP2A6*4 allele, in which CYP2A6 is a homozygous whole-deletion variant, completely lacks enzyme activity. The aim of this study was to examine the effects of CYP2A6*4 genetic polymorphism on smoking behavior and nicotine dependence in a general population of Japanese men. METHODS: The subjects were 124 healthy Japanese men who gave informed consent to give saliva samples...
2015: Fukushima Journal of Medical Science
Yukihiko Kawasaki, Mitsuaki Hosoya, Seiji Yasumura, Tetsuya Ohira, Hiroaki Satoh, Hitoshi Suzuki, Akira Sakai, Akira Ohtsuru, Atsushi Takahashi, Kotaro Ozasa, Gen Kobashi, Kenji Kamiya, Shunichi Yamashita, Masafumi Abe
AIM: To assist in the long-term health management of residents and evaluate the health impacts after the Tokyo Electric Power Company's Fukushima Daiichi Nuclear Power Plant accident in Fukushima Prefecture, the Fukushima prefectural government decided to implement the Fukushima Health Management Survey. This report describes the results for residents aged 15 years or younger who received health checks and evaluates the data obtained from 2011 and 2012. METHODS: The target group consisted of residents aged 15 years or younger who had lived in the evacuation zone...
2015: Fukushima Journal of Medical Science
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