Lin Xin, Zhi-Yang Liu, Chen-Xi Liu, Jie Sheng, Qi Zhou, Yi-Wu Yuan, Zhen-Qi Yue, Hao Lu, Jin-Heng Gan
Gastric cancer metastasis is a major cause of poor prognosis. Our previous research showed that methionine restriction (MR) lowers the invasiveness and motility of gastric carcinoma. In this study, we investigated the particular mechanisms of MR on gastric carcinoma metastasis. In vitro, gastric carcinoma cells (AGS, SNU-5, MKN7, KATO III, SNU-1, and MKN45) were grown in an MR medium for 24 h. In vivo, BALB/c mice were given a methionine-free (Met- ) diet. Transwell assays were used to investigate cell invasion and migration...
March 16, 2024: Experimental Cell Research