Elina Leonova, Nadezhda Ryabokon, Evita Rostoka, Vitalijs Borisovs, Astrida Velena, Egils Bisenieks, Gunars Duburs, Maija Dzintare, Roza Goncharova, Nikolajs Sjakste
This review summarises current knowledge about the genotoxic and genoprotective effects of 1,4-dihydropyridines (DHP) with the main focus on the water-soluble 1,4-DHPs. Most of these water-soluble compounds manifest very low calcium channel blocking activity, which is considered "unusual" for 1,4-DHPs. Glutapyrone, diludine, and AV-153 decrease spontaneous mutagenesis and frequency of mutations induced by chemical mutagens. AV-153, glutapyrone, and carbatones protect DNA against the damage produced by hydrogen peroxide, radiation, and peroxynitrite...
March 1, 2023: Arhiv za Higijenu Rada i Toksikologiju