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Arhiv za Higijenu Rada i Toksikologiju

Kristīne Ošiņa, Elina Leonova, Sergejs Isajevs, Larisa Baumane, Evita Rostoka, Tatjana Sjakste, Egils Bisenieks, Gunars Duburs, Brigita Vīgante, Nikolajs Sjakste
Studies on the pathogenesis of diabetes mellitus complications indicate that the compounds reducing free radicals and enhancing DNA repair could be prospective as possible remedies. Carbatonides, the disodium-2,6-dimethyl-1,4- dihydropyridine-3,5-bis(carbonyloxyacetate) derivatives, were tested for these properties. EPR spectroscopy showed that metcarbatone was an effective scavenger of hydroxyl radicals produced in the Fenton reaction, etcarbatone, and propcarbatone were less effective, styrylcarbatone was ineffective...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Ivana Kerner, Marija Rakovac, Bruno Lazinica
Regular physical activity has a significant impact on health. There is scientific evidence for prescription of exercise in the treatment of at least 26 different chronic non-communicable diseases. Furthermore, it has an indirect role in the preservation of work capacity. The aim of this study was to review the published results of research on the relationship between leisure-time PA and absenteeism due to sickness. Medline database was searched using the keywords "leisuretime physical activity AND (sick leave OR sickness absence OR absenteeism)"...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Marina Cvjetko Bubalo, Kristina Radošević, Ivana Radojčić Redovniković, Igor Slivac, Višnja Gaurina Srček
Over the past three decades a growing awareness of environmental protection prompted the development of so-called green and sustainable technologies. Therefore, academic and wider community intensively explores new chemicals and safer, more energy efficient processes based on a rational compromise between economic, social, and environmental requirements. Due to low volatility and stability, ionic liquids emerged as a potential replacement for traditional volatile and harmful organic solvents. Various studies have been carried out to validate the green character of ionic liquids, whereby data published suggest that these compounds, due to their relatively high toxicity and poor biodegradability, could have an extremely negative impact on the environment...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Mesut Ergan, Ferdi Başkurt, Zeliha Başkurt
This study aimed to determine the frequency of work-related musculoskeletal discomforts (WMSDs) observed in veterinarians and the risk factors that may bring about these. Two hundred and seven veterinarians working in three provinces in south west Turkey were included in the study. The demographic and occupational information on the participants was recorded. The Modified Nordic Musculoskeletal Questionnaire was used to evaluate the musculoskeletal problems of different body parts, which cause difficulties at work and result in staying away from work...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Nina Kočevar Glavač, Svetlana Djogo, Slavica Ražić, Samo Kreft, Marjan Veber
Medicinal plants accumulate heavy metals from contaminated soil, and their consumption can cause poisoning. Our objective was to determine the levels of Pb, Cd, Zn, Cu, Fe, and Mn in four medicinal plant species (Achillea millefolium, Hypericum perforatum, Plantago lanceolata, and Urtica dioica) and their native soil, all sampled at a former smelter. The highest soil Cd, Pb, and Zn levels surpassed the maximum allowed limit 75-fold, 48-fold, and 14-fold, respectively. Their soil levels correlated with those in the plants, but this was not the case with Cu, Fe, and Mn...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Marijana Neuberg, Danica Železnik, Tomislav Meštrović, Rosana Ribić, Goran Kozina
As this issue has not yet been addressed in Croatia, our aim was to explore the presence of the burnout syndrome in nurses and see how it is related to their perception of elder mistreatment in nursing homes and extended care units. The burnout syndrome was assessed in 171 nursing professionals with a standardised Maslach Burnout Inventory for Human Services Survey (MBI-HSS) for three dimensions: emotional exhaustion (EE), depersonalisation (DP), and personal accomplishment (PA). High EE was reported by 43...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Valon Krasniqi, Aleksandar Dimovski, Hasime Qorraj Bytyqi, Aleksandar Eftimov, Livija Šimičević, Nada Božina
Cytochrome P450 genetic polymorphisms are responsible for individual variations in drug metabolism and drug-drug interactions. They are very important for pharmacogenetics, and their frequency varies across different populations. There is a big gap in the knowledge about the CYP gene family polymorphisms in the population of Kosovo, and the aim of our study was to fill that gap by determining the frequency of the most important variant alleles of CYP2C9, CYP2C19, and CYP3A5 in 234 nonrelated Kosovars. The allele frequencies of CYP2C9*2 and 2C9*3 were 17...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Gordana Brozović, Nada Oršolić, Ružica Rozgaj, Fabijan Knežević, Anica Horvat Knežević, Martina Maričić, Dajana Krsnik, Vesna Benković
The aim of this study was to evaluate the DNA damage and repair in kidney cells of Swiss albino mice after repeated exposure to sevoflurane and isoflurane and compare their detrimental effects. We used the alkaline comet assay to establish the genetic damage and measured three parameters: tail length, tail moment, and tail intensity of comets. These parameters were measured immediately after exposure to the above mentioned inhalation anaesthetics, two hours, six hours, and 24 hours later and were compared with the control group...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Branko Petrinec, Isabela Tišma, Marko Šoštarić, Marina Poje Sovilj, Dinko Babić, Vanja Radolić, Igor Miklavčić, Branko Vuković
For years, the town of Slavonski Brod in Croatia has been facing serious problems with air pollution, which is usually attributed to an oil refinery across the Sava River in Bosnia and Herzegovina. While the air quality is being monitored rigorously with regard to nonradioactive matter, no attention has been paid to the possibility of a coincidental radioactive pollution. This study is the first to have addressed this issue. We measured ambient dose rate equivalents at 150 sites and found that none exceeded 120 nSv h-1, while the average was 80 nSv h-1...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Hana Brborović, Ognjen Brborović
Healthcare workers have high rates of injuries and illnesses at the workplace, and both their absence from work due to illness (absenteeism) or working ill (presenteeism) can compromise patient safety and the quality of health care delivered. Following this premise, we wanted to determine whether presenteeism and absenteeism were associated with patient safety culture (PSC) and in what way. Our sample consisted of 595 Croatian healthcare workers (150 physicians and 445 nurses) who answered the short-form WHO Health and Work Performance Questionnaire and the Hospital Survey on Patient Safety Culture...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
Ivana Novak Jovanović, Ante Miličević
We present a new and simpler regression model for the estimation of the first oxidation potentials (Ep1) of flavonoids based on the number of phenolic, alcoholic, and carboxylic OH groups. In the regression we included the Ep1 of 12 polyphenols (mostly flavonols and catechins) that were measured in our laboratory at pH 3. The model yielded r=0.986 and SE=0.040. Later successive inclusions of previously reported Ep values into the regression model, 7 at pH 3, the model (N=19) yielded r=0.980, SE=0.046 and 19 at pH 7 the model (N=38), yielded r=0...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
Martina Oder, Rok Fink, Klemen Bohinc, Karmen Godič Torkar
Bacterial adhesion is a complex process influenced by many factors, including hydrodynamic conditions. They affect the transfer of oxygen, nutrients, and bacterial cells in a water supply and cooling systems. The aim of this study was to identify hydrodynamic effects on bacterial adhesion to and detachment from stainless steel surfaces. For this purpose we observed the behaviour of bacterium L. pneumophila in no-flow and laminar and turbulent flow conditions simulated in a fluid flow chamber. The bacterial growth in no-flow and laminar flow conditions was almost identical in the first 24 h, while at 48 and 72 h of incubation, the laminar flow stimulated bacterial growth...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
Saziye Sezin Palabiyik, Pinar Erkekoglu, Murat Kızılgun, Gonul Sahin, Belma Kocer-Gumusel
This study was designed to investigate the in vivo effects of ochratoxin A (OTA) and/or lycopene on the levels of selenium, zinc, and copper in the liver, kidneys, and testes of male Sprague-Dawley rats. The rats were treated with OTA (0.5 mg kg-1 day-1) and/or lycopene (5 mg kg-1 day-1) by gavage for 7 or 14 days. Trace element levels were measured by atomic absorption spectrometry. OTA significantly lowered selenium (20 % in the liver, 17 % in the kidney, and 40 % in the testis), zinc (24 % in the liver, 23 % in the kidney, and 26 % in the testis), and copper levels (40 % in the liver and 10 % in the kidney)...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
Marija Ljubičić, Marijana Matek Sarić, Irena Colić Barić, Ivana Rumbak, Draženka Komes, Zvonimir Šatalić, Raquel P F Guiné
Unlike fast and restaurant food, diet rich in fibre is known to contribute significantly to health. The aim of our study was to assess eating habits such as consumption of fibre-rich, fast, and restaurant food of the general population in Croatia. For this purpose we used a validated survey designed by the Polytechnic Institute Viseu in Portugal, which includes questions about demographics, good eating habits related to the consumption of the main sources of dietary fibre (fruit, vegetables, and whole grains), and unhealthy eating habits related to the consumption of fast food and restaurant meals...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
Karmen Godič Torkar, Sanja Ivić
This study was conducted to determine the bacterial colonization of some bacterial groups, including extended-spectrum β-lactamase (ESBLs) producers and methicillin-resistant Staphylococcus aureus (MRSA), on surfaces of the equipment and instruments in patient rooms and other workspaces in three different medical wards. The number of microorganisms on swabs was determined with the colony count method on selective microbiological mediums. The aerobic mesophylic microorganisms were found in 73.5 % out of 102 samples, with the average and maximum values of 2...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
Kinga Stuper-Szablewska, Tomasz Rogoziński, Juliusz Perkowski
Wood compounds, especially sterols, are connected with the level of contamination with microscopic fungi. Within this study, tests were conducted on wood dust samples collected at various work stations in a pine and birch timber conversion plant. Their contamination with mycobiota was measured as the concentration of ergosterol (ERG) by ultra performance liquid chromatography (UPLC). Another aim of this study was to assess the effect of contamination with microscopic fungi on the sterol contents in wood dusts...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
Jean-Paul Bourdineaud, Maja Šrut, Anamaria Štambuk, Mirta Tkalec, Daniel Brèthes, Krešimir Malarić, Göran I V Klobučar
Eisenia fetida earthworms were exposed to electromagnetic field (EMF) at a mobile phone frequency (900 MHz) and at field levels ranging from 10 to 120 V m-1 for a period of two hours (corresponding to specific absorption rates ranging from 0.13 to 9.33 mW kg-1). Potential effects of longer exposure (four hours), field modulation, and a recovery period of 24 h after two hours of exposure were addressed at the field level of 23 V m-1. All exposure treatments induced significant DNA modifications as assessed by a quantitative random amplified polymorphic DNA-PCR...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
Irena Brčić Karačonji, Sonja Anić Jurica, Dario Lasić, Karlo Jurica
Phthalates are esters of phthalic acid and aliphatic alcohol added to plastic to improve its softness, flexibility, and extensibility. They easily migrate from plastic products into the environment because of their physical and chemical properties. This review summarises their characteristics, distribution in the environment, monitoring, use, toxic effects on human health, regulatory limits in different matrices and products, and tolerable daily intake. The studies we have reviewed suggest that phthalates have a potential to affect reproduction and development in humans...
June 27, 2017: Arhiv za Higijenu Rada i Toksikologiju
Bożena Cwalina-Ambroziak, Tomasz P Kurowski, Agnieszka Waśkiewicz, Piotr Goliński, Arkadiusz Stępień, Małgorzata Głosek-Sobieraj, Adam Perczak
The fungi of the genus Fusarium cause Fusarium head blight (FHB), a devastating disease that reduces grain yield and quality. They also produce mycotoxins which may pose a serious threat to human and animal health. This study investigated the effects of NPK fertilisation, foliar application of Cu, Zn, and Mn, applied separately and in combination, and of the Nano-Gro® organic growth stimulator on the occurrence of FHB in cultivar Dańkowskie Diament rye based on the mycological analysis of kernels and on the concentrations of Fusarium mycotoxins in grain...
March 1, 2017: Arhiv za Higijenu Rada i Toksikologiju
Tihomir Kovač, Marija Kovač, Ivica Strelec, Ante Nevistić, Maja Molnar
The antifungal and antiaflatoxigenic effects of two series of coumarinyl thiosemicarbazides on Aspergillus flavus NRRL 3251 were studied. Fungi were grown in YES medium for 72 h at 29 °C in the presence of 0, 0.1, 1, and 10 μg mL-1 of coumarinyl thiosemicarbazides: one series with substitution in position 7 and another with substitution in position 4 of the coumarin core. Dry mycelia weight determination was used for antifungal activity estimation, while the aflatoxin B1 content in YES media, determined by the dilute and shoot LC-MS/MS technique, was used for the antiaflatoxigenic effect estimation...
March 1, 2017: Arhiv za Higijenu Rada i Toksikologiju
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