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Arhiv za Higijenu Rada i Toksikologiju

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https://www.readbyqxmd.com/read/29604201/discrepancies-in-the-evaluation-of-incapacity-for-work-in-a-patient-with-epidermolysis-bullosa-acquisita-between-public-pension-fund-and-occupational-medicine-expert-raise-the-issue-of-competencies
#1
Hrvoje Lalić
Abstrat A 50-year-old female patient suffering from a severe form of epidermolysis bullosa acquisita (EBA) took legal action against the Croatian Pension Insurance Institute (CPII) in an attempt to overturn their assessment that she was no longer capable of working as a seamstress but still capable of doing administrative jobs. Her claim was that she was not capable of doing any job at all. She was first diagnosed EBA in 2000, and the disease progressed slowly with intermittent remissions. In 2012, skin erosions appeared on her feet, followed by the loss of all toenails and lesions and infiltrations on the tongue and oral mucosa...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29604200/the-efficiency-of-lactic-acid-bacteria-against-pathogenic-fungi-and-mycotoxins
#2
Adam Perczak, Piotr Goliński, Marcin Bryła, Agnieszka Waśkiewicz
Mycotoxins are produced by some fungal species of the genera Aspergillus, Penicillium, and Fusarium and are common contaminants of a wide range of food commodities. Numerous strategies are used to minimise fungal growth and mycotoxin contamination throughout the food chain. This review addresses the use of lactic acid bacteria, which can inhibit fungal growth and participate in mycotoxin degradation and/or removal from contaminated food. Being beneficial for human and animal health, lactic acid bacteria have established themselves as an excellent solution to the problem of mycotoxin contamination, yet in practice their application in removing mycotoxins remains a challenge to be addressed by future research...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29604199/antimycobacterial-potential-of-the-juniper-berry-essential-oil-in-tap-water
#3
Dolores Peruč, Ivana Gobin, Maja Abram, Dalibor Broznić, Tomislav Svalina, Sanja Štifter, Mladenka Malenica Staver, Brigita Tićac
Mycobacterium avium complex-related diseases are often associated with poorly maintained hot water systems. This calls for the development of new control strategies. The aim of this study was to investigate the activity of essential oils (EOs) from the Mediterranean plants, common juniper, immortelle, sage, lavandin, laurel, and white cedar against Mycobacterium avium ssp. avium, Mycobacterium intracellulare, and Mycobacterium gordonae in culturing broth and freshwater as their most common habitat. To do that, we developed a new method of water microdilution to determine their minimal effective concentrations (MEC)...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29604198/evaluation-of-breath-alcohol-analysers-by-comparison-of-breath-and-blood-alcohol-concentrations
#4
Andreja Jurič, Andrija Fijačko, Lana Bakulić, Tanja Orešić, Ines Gmajnički
The main goal of this study was to determine the reliability of hand-held breath alcohol analysers currently approved for roadside screening of traffic offenders. The first part of the study included a retrospective data analysis of 714 offence records collected in 2011. Blood alcohol concentrations (BAC) obtained from the offenders 0-303 min after the police had screened them for breath alcohol concentration (BrAC) were back-calculated (cBAC) to assess the accuracy of breathalyser screening. All participants were in the alcohol elimination phase, and our analyses did not reveal any significant differences between cBAC and BrAC...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29604197/glutathionylation-a-regulatory-role-of-glutathione-in-physiological-processes
#5
Kristina Dominko, Domagoj Đikić
Glutathione (γ-glutamyl-cysteinyl-glycine) is an intracellular thiol molecule and a potent antioxidant that participates in the toxic metabolism phase II biotransformation of xenobiotics. It can bind to a variety of proteins in a process known as glutathionylation. Protein glutathionylation is now recognised as one of important posttranslational regulatory mechanisms in cell and tissue physiology. Direct and indirect regulatory roles in physiological processes include glutathionylation of major transcriptional factors, eicosanoids, cytokines, and nitric oxide (NO)...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29604196/occupational-exposure-to-blood-and-bodily-fluids-among-healthcare-workers-in-serbian-general-hospitals
#6
Bojana Mandić, Stefan Mandić-Rajčević, Ljiljana Marković-Denić, Petar Bulat
The risk of occupational bloodborne infections (HBV, HCV, and HIV) among healthcare workers remains a serious issue in developing countries. The aim of this study was to estimate occupational exposure to bloodborne infections among general hospital workers in Serbia. This cross-sectional study was conducted in the spring of 2013 and included 5,247 healthcare workers from 17 general hospitals. The questionnaire was anonymous, self-completed, and included sociodemographic information with details of blood and bodily fluid exposure over the career and in the previous year (2012)...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29604195/role-of-gene-polymorphisms-in-vitamin-d-metabolism-and-in-multiple-sclerosis
#7
Aylin Elkama, Bensu Karahalil
Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) resulting in neurological impairment and disability. There is evidence that adequate vitamin D levels may lower the risk of MS development. The aetiology of MS is complex and involves both genetic and environmental factors. In fact, not one but several genes are believed to lead to the disease. As for environmental factors, one of the most important risk factors is vitamin D deficiency, which, in turn, is closely related to gene polymorphisms that play a role in vitamin D metabolism and regulation...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29604194/canned-sea-fish-marketed-in-serbia-their-zinc-copper-and-iron-levels-and-contribution-to-the-dietary-intake
#8
Aleksandar R Popović, Dubravka J Relić, Danijela V Vranić, Jelena A Babić-Milijašević, Lato L Pezo, Jasna M Đinović-Stojanović
The aim of this study was to determine the levels of Zn, Cu, and Fe in three canned fish species marketed Serbia to see if they meet recommended daily intake requirements or exceed safety limits. We collected a total of 207 samples of canned tuna, sardine, and mackerel, in oil or tomato sauce and analysed them with inductively coupled plasma mass spectrometry (ICP-MS) after acid digestion. The highest levels were obtained for Zn (15.1 mg kg-1) and Cu (1.37 mg kg-1) in sardine in oil and tomato sauce, respectively, and for Fe (18...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337687/comparison-of-the-solid-phase-and-liquid-liquid-extraction-methods-for-methadone-determination-in-human-serum-and-whole-blood-samples-using-gas-chromatography-mass-spectrometry
#9
Maja Veršić Bratinčević, Tanja Visković, Davorka Sutlović
The aim of this study was to determine the optimal biological sample and the optimal extraction technique for monitoring methadone concentrations in biological samples. We analysed methadone in serum and whole blood samples using gas chromatography/mass spectrometry (GC/MS). Before analysis, we compared five solid-phase extraction (SPE) and two liquid-liquid extraction (LLE) methods and determined that SPE with Supelco LC-18 in serum yielded the best extraction efficiency. The limit of detection was 10 ng mL-1 and the limit of quantification 25 ng mL-1...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337686/forgotten-public-health-impacts-of-cancer-an-overview
#10
Susana Viegas, Carina Ladeira, Ana Costa-Veiga, Julian Perelman, Goran Gajski
Cancer is one of the diseases of greatest concern in developed countries and much effort has been invested in discovering and developing therapeutics for curing cancer. Despite the improvements in antineoplastic therapeutics in the last decades, cancer is still one of the most harmful diseases worldwide. The global burden of cancer also implies financial costs: these can be direct costs, such as those related to treatment, care, and rehabilitation and indirect, which include the loss of economic output due to missed work (morbidity costs) and premature death (mortality costs)...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337685/radiological-risk-assessment-an-overview-of-the-erica-integrated-approach-and-the-erica-tool-use
#11
Ivica Prlić, Ana Mostečak, Marija Surić Mihić, Želimir Veinović, Luka Pavelić
The ERICA project (Environmental Risk from Ionising Contaminants: Assessment and Management) was co-funded by the European Union as part of the 6th Framework Programme (FP EURATOM). The project was carried out between 2004 and 2007 as the collective work of 15 organisations in seven European countries. Two significant outputs of the project are the ERICA Integrated Approach and the ERICA Tool. The ERICA Integrated Approach consists of three elements: assessment, risk characterisation and management. The ERICA Tool is a practical implementation of the assessment component of the ERICA Integrated Approach and has a three-tier structure...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337684/hepatotoxicity-associated-with-statins
#12
Bensu Karahalil, Emine Hare, Göksel Koç, İrem Uslu, Kerem Şentürk, Yağmur Özkan
Treatment with statins is known all over the world. They are generally considered safe at therapeutic doses. Nevertheless, clinical trials are not enough to assess their scarce adverse effects such as idiosyncratic drug induced liver injury (DILI). Due to some conditions, such as concomitant usage (drug-drug interaction using an identical metabolising enzyme) and genetic polymorphisms, there is an increasing concern about their safety. Hepatotoxicity and rhabdomyolysis have begun to appear in published studies...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337683/how-protein-coronas-determine-the-fate-of-engineered-nanoparticles-in-biological-environment
#13
Ivona Capjak, Sandra Šupraha Goreta, Darija Domazet Jurašin, Ivana Vinković Vrček
Nanomedicine is a booming medical field that utilises nanoparticles (NPs) for the development of medicines, medical devices, and diagnostic tools. The behaviour of NPs in vivo may be quite complex due to their interactions with biological molecules. These interactions in biological fluids result in NPs being enveloped by dynamic protein coronas, which serve as an interface between NPs and their environment (blood, cell, tissue). How will the corona interact with this environment will depend on the biological, chemical, and physical properties of NPs, the properties of the proteins that make the corona, as well as the biological environment...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337682/adverse-effects-of-organophosphorus-pesticides-on-the-liver-a-brief-summary-of-four-decades-of-research
#14
Somayyeh Karami-Mohajeri, Ahmad Ahmadipour, Hamid-Reza Rahimi, Mohammad Abdollahi
Organophosphorus pesticides (OPs) are widely used volatile pesticides that have harmful effects on the liver in acute and chronic exposures. This review article summarises and discusses a wide collection of studies published over the last 40 years reporting on the effects of OPs on the liver, in an attempt to propose general mechanisms of OP hepatotoxicity and possible treatment. Several key biological processes have been reported as involved in OP-induced hepatotoxicity such as disturbances in the antioxidant defence system, oxidative stress, apoptosis, and mitochondrial and microsomal metabolism...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337681/dissipation-dynamics-of-terbuthylazine-in-soil-during-the-maize-growing-season
#15
Sanja Stipičević, Gordana Mendaš, Marija Dvoršćak, Sanja Fingler, Natalija Galzina, Klara Barić
Ever since terbuthylazine (TBA) replaced atrazine in herbicide crop treatment, its much greater persistence has raised considerable environmental concern. The aim of our field experiment was to establish the dissipation dynamics of TBA and its degradation product desethylterbuthylazine (DET) in soil over five months of maize growth. We applied TBA as part of pre-emergent treatment in the regular and double-the-regular amounts. Soil samples were collected periodically at the following depths: 0-10 cm, 10-20 cm, 20-30 cm, and 30-50 cm...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337680/in-vitro-assessment-of-the-cytotoxic-dna-damaging-and-cytogenetic-effects-of-hydroquinone-in-human-peripheral-blood-lymphocytes
#16
Karlo Jurica, Irena Brčić Karačonji, Vesna Benković, Nevenka Kopjar
This study investigated the mechanisms of hydroquinone toxicity and assessed the relationships between its cytotoxic, genotoxic, and cytogenetic effects tested at 8, 140, and 280 μg mL-1 in human peripheral blood lymphocytes exposed for 24 h. The outcomes of the treatments were evaluated using the apoptosis/necrosis assay, the alkaline comet assay, and the cytokinesis-block micronucleus (CBMN) cytome assay. The tested hydroquinone concentrations produced relatively weak cytotoxicity in resting lymphocytes, which mostly died via apoptosis...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337679/the-effects-of-physical-activity-on-chronic-subclinical-systemic-inflammation
#17
Alba Maria Dalbello Tir, Marina Labor, Davor Plavec
Chronic subclinical systemic inflammation (CSSI) is a pathogenic event and a common risk factor for many noncommunicable diseases like atherosclerosis, metabolic syndrome, cardiovascular disease, insulin resistance and type 2 diabetes, cancer, and obstructive lung disease. On the other hand, regular physical activity has been found to reduce this risk. Many studies of different design were conducted to assess the association between inflammatory mediators as markers of CSSI and regular physical activity. The aim of this review was to present the current level of evidence and understanding of potential mechanisms by which physical activity reduces inflammatory mediators involved in CSSI and the types of physical activity required for the expected effect...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337678/salivary-scd14-as-a-potential-biomarker-of-dental-caries-activity-in-adults
#18
Ljerka Prester, Nives Protrka, Jelena Macan, Marina Katunarić
CD14 is a co-receptor involved in the recognition of Gram-negative and Gram-positive bacteria, the latter known to cause dental caries. The aim of this study was to determine whether soluble CD14 (sCD14) in saliva was associated with caries activity and the collection method from the saliva. The study included 55 participants aged 20 to 40 years, 30 with dental caries and 25 caries-free controls. We collected 110 saliva samples in total, 55 of resting saliva and 55 of mechanically stimulated saliva. Median levels of sCD14, measured with a matrix-matched enzyme-linked immunosorbent assay (ELISA), were higher in the caries-active than in the caries-free group in either resting (203...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/28976888/modifications-of-expression-of-genes-and-proteins-involved-in-dna-repair-and-nitric-oxide-metabolism-by-carbatonides-disodium-2-6-dimethyl-1-4-dihydropyridine-3-5-bis-carbonyloxyacetate-derivatives-in-intact-and-diabetic-rats
#19
Kristīne Ošiņa, Elina Leonova, Sergejs Isajevs, Larisa Baumane, Evita Rostoka, Tatjana Sjakste, Egils Bisenieks, Gunars Duburs, Brigita Vīgante, Nikolajs Sjakste
Studies on the pathogenesis of diabetes mellitus complications indicate that the compounds reducing free radicals and enhancing DNA repair could be prospective as possible remedies. Carbatonides, the disodium-2,6-dimethyl-1,4- dihydropyridine-3,5-bis(carbonyloxyacetate) derivatives, were tested for these properties. EPR spectroscopy showed that metcarbatone was an effective scavenger of hydroxyl radicals produced in the Fenton reaction, etcarbatone, and propcarbatone were less effective, styrylcarbatone was ineffective...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/28976887/leisure-time-physical-activity-and-absenteeism
#20
Ivana Kerner, Marija Rakovac, Bruno Lazinica
Regular physical activity has a significant impact on health. There is scientific evidence for prescription of exercise in the treatment of at least 26 different chronic non-communicable diseases. Furthermore, it has an indirect role in the preservation of work capacity. The aim of this study was to review the published results of research on the relationship between leisure-time PA and absenteeism due to sickness. Medline database was searched using the keywords "leisuretime physical activity AND (sick leave OR sickness absence OR absenteeism)"...
September 26, 2017: Arhiv za Higijenu Rada i Toksikologiju
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