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Indian Journal of Tuberculosis

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https://www.readbyqxmd.com/read/27865246/renal-tuberculosis-presenting-as-acute-pyelonephritis-a-rarity
#1
Ajay Kumar Verma, Ashwini Kumar Mishra, Manoj Kumar, Surya Kant, Anubhuti Singh, Ajay Singh
One of the major health problems faced particularly by the developing world since ages is that of tuberculosis (TB). Genito-urinary tuberculosis (GUTB) is the second most common extrapulmonary TB, with kidney being the most frequent site of infection. Due to the diverse and atypical clinical manifestations of urinary TB, the disease is easy to misdiagnose. The diagnosis of renal TB should be suspected in a nonspecific bacterial cystitis associated with a therapeutic failure or a sterile pyuria and a past history of pulmonary TB with important radiologic findings, particularly with the help of CT scan...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865245/adolescent-with-recurrent-tuberculosis-can-it-be-chronic-granulomatous-disease
#2
Yashashree Gupta, Ira Shah
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder with recurrent bacterial and fungal infections like Staphylococcus aureus, Nocardia spp, Serratia marcescens, Burkholderia cepacia, Salmonella spp. and Aspergillus species. We present a 13-year-old male child who had 3 episodes of tuberculosis (TB) at 5 years, 8 years and 13 years of age, respectively, with no other intercurrent infections and who was diagnosed as CGD at the age of 13 years. This case highlights the possibility of phenotypic variations of CGD...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865244/tubercular-osteomyelitis-of-calcaneum-bone-a-rare-occurrence
#3
Rajendra Takhar, Motilal Bunkar, Savita Arya, Nitin Mirdha
In spite of the endemic nature of tuberculosis in India, skeletal tuberculosis is relatively infrequent. Involvement of foot bones is uncommon and isolated calcaneum is even rarer. Osteoarticular tuberculosis is a diagnostic enigma, as the characteristic signs and symptoms of this disease may be absent, or mimic other disorders, leading to emergence of complications and therapeutic delay, particularly when the disease affects unusual sites. Here, we are reporting the case of 20-year-old male, who presented with a rare localization of tubercular osteomyelitis involving the calcaneum without adjacent joint involvement to draw attention to this exceptional location in adults, managed with anti-tubercular treatment and gained excellent recovery...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865243/lessons-learnt-from-active-tuberculosis-case-finding-in-an-urban-slum-setting-of-agra-city-india
#4
Banuru Muralidhara Prasad, Srinath Satyanarayana, Sarabjit Singh Chadha
Active case finding (ACF) is recognized as one of the key strategies to reach the missing 3 million cases in high tuberculosis (TB) burden countries. In India, we conducted ACF as a pilot project to assess its operational feasibility in four slums of Agra city in 2012 and covered 3940 households (in 14 wards) with a population of 21,870. Trained community volunteers visited households with an intention to provide information on TB and refer those with cough ≥2 weeks for sputum smear examination. Volunteers identified 8 persons with cough of ≥2 weeks by asking the first or the main respondent of the household...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865242/a-study-on-knowledge-and-awareness-about-tuberculosis-in-senior-school-children-in-bangalore-india
#5
K Vanaja, Reshma Banu, Lokeshwar Reddy, P Chethan Kumar, Chaitra Srinivas, T Rajani, Navyashree, H S Shekar
BACKGROUND: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis), commonly affecting the lungs. All health care professionals including the pharmacists provide a valuable public health role in promoting community awareness of TB particularly in reducing stigma attached to TB. Thus, creating awareness at a community level could play a vital role in control and prevention of TB. OBJECTIVES: To determine whether educational intervention would affect the level of TB awareness among students of selected schools and pre-university colleges (PUCs) in Bangalore urban and Bangalore rural regions...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865241/tobacco-use-and-its-impact-on-pulmonary-health-among-elderly-population-in-rural-area-of-muzaffarnagar-a-cross-sectional-study
#6
Sanjeev Davey, Jai Vir Singh, Santosh Kumar Raghav, Khursheed Muzammil, Rama Shankar
BACKGROUND: The tobacco use is significant in Indian rural population. Among them, elderly people in rural area are at special risk due to ageing and other factors. The impact of tobacco use on elderly health, therefore, needs to be studied in depth in rural context. OBJECTIVE: To study the patterns of tobacco use and its consequent impact on pulmonary health of the elderly. DESIGN AND METHODOLOGY: A community-based cross-sectional study was done (April 1st to September 30th, 2014) in the field practice area (village Bilaspur) of Rural Health Training Centre (RHTC) of Muzaffarnagar Medical College, Muzaffarnagar...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865240/prediction-equations-for-spirometry-in-adults-in-western-india
#7
Unnati Desai, Jyotsna M Joshi, S K Chhabra, Mujeeb-Ur Rahman
BACKGROUND: Spirometry is an essential investigation in pulmonology. The predicted normal spirometry values depend on various physiological parameters. This study was conducted to collect updated information on pulmonary functions in normal adults from western India. MATERIAL AND METHODS: A prospective observational study was undertaken at a tertiary hospital in Mumbai enrolling healthy subjects, 18-75 years, with ethnic origin from western India. Spirometry measurements were carried out as per ATS/ERS-2005 guidelines using a non-heated Fleish Pneumotachograph spirometer...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865239/patterns-of-granulomatous-responses-in-tb-lymphadenitis-and-their-correlation-with-treatment-outcomes
#8
Debarshi Saha, Komal Rautela, Ashwani Kumar, Pooja K Suresh
INTRODUCTION: Four patterns are noted in aspirates of TB lymphadenitis with or without concomitant HIV. They are granulomatous, necrotizing granulomatous, predominantly necrotizing and necrotizing suppurative designated pattern 1, 2, 3 and 4, respectively. The present study attempted to correlate granulomatous patterns, Acid Fast Bacilli (AFB) density with treatment outcomes. MATERIALS AND METHODS: The MGG and Papanicolaou stained slides of 56 lymphadenitis patients, 38 TB and 18 TB with seropositive HIV were studied for two years...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865238/tuberculosis-prevalence-and-socio-economic-differentials-in-the-slums-of-four-metropolitan-cities-of-india
#9
Palaniappan Marimuthu
AIM: To understand tuberculosis (TB) prevalence among the slum dwellers of metropolitan cities of India and the factors associated with TB prevalence. METHODS: National Family Health Survey-III data for four metropolitan cities namely, Delhi, Mumbai, Kolkata and Chennai was used for this study. RESULTS: Prevalence of TB is significantly (P=0.001) higher in the slums than non-slums of Mumbai, Chennai and Kolkata cities. As the living standard increases, TB prevalence decreases...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865237/smoked-and-smokeless-tobacco-use-among-pulmonary-tuberculosis-patients-under-rntcp-in-urban-puducherry-india
#10
Veerakumar Arumugam Mariappan, Swaroop Kumar Sahu, Sonali Sarkar, Shivanand Kattimani, Govindarajan Soundappan
BACKGROUND: Smoking is associated with unfavourable treatment outcomes like failures and defaults among the TB patients. OBJECTIVES: To study the prevalence and pattern of tobacco use among the pulmonary tuberculosis (PTB) patients in urban Pondicherry and study the association of various socio-demographic variables with current smoked and smokeless tobacco users. METHODS: A cross-sectional study was conducted among 235 PTB patients from 6 randomly selected urban PHCs of Pondicherry from Jan 2013 to March 2014...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865236/pcr-targeting-is6110-in-diagnosing-tuberculosis-in-children-in-comparison-to-mgit-culture
#11
Rajeshwar Dayal, Dipti Agarwal, Harish Pathak, Shehraj Feroz, Manoj Kumar, Devendra S Chauhan, Rakesh Bhatia
BACKGROUND: Diagnosis of tuberculosis (TB) in children is difficult in children especially in extrapulmonary tuberculosis (EPTB). This study was conducted to evaluate the use of polymerase chain reaction (PCR) targeting IS6110 in the diagnosis of TB in children with pulmonary TB and EPTB and also to compare its performance with MGIT 960 culture and conventional microscopy. METHODS: A total of 142 cases (50 pulmonary, 92 extrapulmonary) of suspected TB patients <15 years of age were included in the study...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865235/role-of-real-time-pcr-for-detection-of-tuberculosis-and-drug-resistance-directly-from-clinical-samples
#12
Parashuram Rao, Kiran Chawla, Vishnu Prasad Shenoy, Chiranjay Mukhopadhyay
BACKGROUND: Only a few studies done earlier in India reveal the utility of real-time PCR in detecting drug resistance in cases of pulmonary tuberculosis. OBJECTIVES: The study was carried out to standardise real-time PCR (Quantitative real-time PCR, qPCR) targeting 16s RNA for the rapid detection of tuberculosis and its drug resistance from suspected TB patients. MATERIALS AND METHODS: Sputum samples from 100 clinically suspected tuberculosis patients, after processing were subjected to microscopy, MGIT culture and qPCR...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865234/rapid-detection-of-extensively-drug-resistant-xdr-tb-strains-from-multidrug-resistant-tuberculosis-mdr-tb-cases-isolated-from-smear-negative-pulmonary-samples-in-an-intermediate-reference-laboratory-in-india
#13
Himanshu Vashistha, M Hanif, Sanjeev Saini, Ashwani Khanna, Srashty Sharma, Zeeshan Sidiq, Vasim Ahmed, Manoj Dubey, K K Chopra, Divya Shrivastava
BACKGROUND: Direct sputum smear microscopy is commonly used for diagnosing tuberculosis (TB). The objectives of the study were first, to determine the recovery of Mycobacterium tuberculosis in smear-negative sputum samples through liquid culture (using MGIT 960) and solid culture (using LJ slant) and second, to screen multidrug-resistant isolates through line probe assay and further third, to identify XDR isolates through MGIT second-line DST from these positive MDR cultures in Delhi region...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865233/cyp2e1-polymorphism-acetylator-profiles-and-drug-induced-liver-injury-incidence-of-indonesian-tuberculosis-patients
#14
Dyah A Perwitasari, Lalu M Irham, Endang Darmawan, Ully A Mulyani, J Atthobari
OBJECTIVE: A polymorphism of CYP2E1 may be directly associated with the development of INH hepatotoxicity. We conducted this study to evaluate the association between polymorphisms of CYP2E1, Isoniazid (INH) concentration and the acetylator status of INH in cases of Indonesian tuberculosis patients with drug-induced liver disease (DILI). METHODS: We conducted our study with a cohort design consisting of 55 Indonesian adult tuberculosis (TB) patients. Acetylating phenotypes were studied in using the metabolic ratio of plasma AcHZ/HZ...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27865232/bedaquiline-introducing-a-new-drug-to-the-mdr-tb-armamentarium
#15
EDITORIAL
Chrispin Kambili
No abstract text is available yet for this article.
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27451826/-cryptic-mediastinal-tuberculosis-with-myasthenia-thymoma-complex
#16
George Jose Valooran, Shiv Kumar Nair, Krishnan Chandrasekharan, Sunitha Thomas, Joejo John
Mediastinal tuberculosis, although common in endemic areas, is rare in association with myasthenia-thymoma complex. Immunosuppressive therapy for myasthenia with thymoma might increase the susceptibility for mediastinal tuberculosis. Previous reports suggest aggravation of myasthenic symptoms with this association. This rare combination of pathologies adds to the diagnostic dilemma of the surgeon. Further research is warranted in the management aspects of this combination as regards to the timing of radiotherapy, weaning of immunosuppression and anti-tubercular therapy after maximal thymectomy...
April 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27451825/an-outbreak-of-multidrug-resistant-tuberculosis-among-a-family
#17
Sinem Iliaz, Emel Caglar, Orhan Kaya Koksalan, Efsun Gonca Ugur Chousein
Tuberculosis is a major public health problem and it may be complicated by multidrug-resistant tuberculosis (MDR-TB). Wide transmission among immunocompetent contacts of the index case is possible. If you detect tuberculosis in two contacts of the index case, it is called an outbreak. The aim of our paper is to evaluate the characteristics of a MDR-TB outbreak affecting 7 people in a family treated during 2012-2014 in Istanbul Yedikule Training and Research Hospital for Chest Disease and Thoracic Surgery, Turkey...
April 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27451824/multiple-lumps-in-the-breast-due-to-mycobacterium-fortuitum
#18
Shirish S Chandanwale, Ishita Gulati, Dadaso S Baravkar, Sumedha P Shinde, Neha Mishra
Although breast tissue is the most resistant to tuberculosis, its incidence is increasing worldwide. High incidence of breast tuberculosis is presumed in India. The rapidly growing nontubercular mycobacteria, such as Mycobacterium fortuitum and Mycobacterium chelonae, are of increasing clinical importance because infections due to these organisms are often hospital acquired. The true incidence of M. fortuitum is unknown but it has been estimated to be between 4 and 6 cases per one million people. It causes skin or soft tissue infections following trauma or surgery...
April 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27451823/non-communicable-disease-comorbidities-and-risk-factors-among-tuberculosis-patients-meghalaya-india
#19
Bibha Marak, Prabhdeep Kaur, Sudha R Rao, Sriram Selvaraju
We did cross-sectional study to estimate the prevalence of tobacco, alcohol use, hypertension and diabetes among tuberculosis (TB) patients in comparison to the non-TB patients in East Garo Hills District, Meghalaya, India. We surveyed 110 TB patients attending outpatient TB clinic and 110 age/sex matched non-TB subjects from the general outpatient department as comparison group. Prevalence of ever smoking was 74.5% and 55.4%; alcohol consumption 31.0% and 22.3%; hypertension 24.5% and 17.3%; diabetes 7.5%, 4...
April 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27451822/drug-susceptibility-testing-of-rapidly-growing-mycobacteria-in-extrapulmonary-tuberculosis
#20
Geeta V Gole, Reena Set, Nishat Khan, Jayanthi Shastri
There has been an increasing awareness of the rapidly growing mycobacteria (RGM), of which numerous species and phylogenetic groups are clearly established human pathogens. It is important to appropriately distinguish RGM from other mycobacteria, as first-line antituberculous drugs are ineffective for their treatment. Variability in susceptibility of RGM is seen in relation to species, different geographical areas, and time. Therefore, we conducted a study to speciate the isolates of RGM and perform antimicrobial susceptibility testing...
April 2016: Indian Journal of Tuberculosis
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