Marguerite R Irvin, Tian Ge, Amit Patki, Vinodh Srinivasasainagendra, Nicole D Armstrong, Brittney Davis, Alana C Jones, Emma Perez, Lauren Stalbow, Matthew Lebo, Eimear Kenny, Ruth J F Loos, Maggie C Y Ng, Jordan W Smoller, James B Meigs, Leslie A Lange, Elizabeth W Karlson, Nita A Limdi, Hemant K Tiwari
African Americans (AAs) have been underrepresented in polygenic risk score (PRS) studies. Herein, we integrated genome-wide data from multiple observational studies on type 2 diabetes (T2D), encompassing a total of 101,987 AAs, to train and optimize an AA focused T2D PRS (PRSAA), using a Bayesian polygenic modeling method (PRS-CS). We further tested the score in three independent studies with a total of 7,275 AAs. We then compared the PRSAA to other published scores. Results show that a 1 standard deviation increase in the PRSAA was associated with 40%-60% increase in the odds of T2D (OR=1...
March 12, 2024: Diabetes