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Diabetes

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https://www.readbyqxmd.com/read/29038309/deletion-of-protein-kinase-d1-in-pancreatic-beta-cells-impairs-insulin-secretion-in-high-fat-fed-mice
#1
Valérie Bergeron, Julien Ghislain, Kevin Vivot, Natalia Tamarina, Louis H Philipson, Jens Fielitz, Vincent Poitout
Beta-cell adaptation to insulin resistance is necessary to maintain glucose homeostasis in obesity. Failure of this mechanism is a hallmark of type 2 diabetes (T2D). Hence, factors controlling functional beta-cell compensation are potentially important targets for the treatment of T2D. Protein kinase D1 (PKD1) integrates diverse signals in the beta cell and plays a critical role in the control of insulin secretion. However, the role of beta-cell PKD1 in glucose homeostasis in vivo is essentially unknown. Using beta-cell specific, inducible PKD1 knock-out mice (βPKD1KO), we examined the role of beta-cell PKD1 under basal conditions and during high-fat feeding...
October 16, 2017: Diabetes
https://www.readbyqxmd.com/read/29025860/negative-regulation-of-trpa1-by-amp-activated-protein-kinase-in-primary-sensory-neurons-as-a-potential-mechanism-of-painful-diabetic-neuropathy
#2
Shenglan Wang, Kimiko Kobayashi, Yoko Kogure, Hiroki Yamanaka, Satoshi Yamamoto, Hideshi Yagi, Koichi Noguchi, Yi Dai
AMP activated protein kinase (AMPK) is a widely expressed intracellular energy sensor that monitors and modulates energy expenditure. Transient receptor potential ankyrin 1 (TRPA1) channel is a widely recognized chemical and thermal sensor that plays vital roles in pain transduction. Here, we discovered a functional link between AMPK and TRPA1 in dorsal root ganglion (DRG) neurons, in which AMPK activation rapidly resulted in downregulation of membrane-associated TRPA1 and its channel activity within minutes...
October 12, 2017: Diabetes
https://www.readbyqxmd.com/read/29025859/erratum-direct-substrate-delivery-into-mitochondrial-fission-deficient-pancreatic-islets-rescues-insulin-secretion-diabetes-2017-66-1247-1257
#3
Uma D Kabra, Katrin Pfuhlmann, Adriana Migliorini, Susanne Keipert, Daniel Lamp, Olle Korsgren, Moritz Gegg, Stephen C Woods, Paul T Pfluger, Heiko Lickert, Charles Affourtit, Matthias H Tschöp, Martin Jastroch
No abstract text is available yet for this article.
October 12, 2017: Diabetes
https://www.readbyqxmd.com/read/29017999/erratum-genetic-disruption-of-adenosine-kinase-in-mouse-pancreatic-%C3%AE-cells-protects-against-high-fat-diet-induced-glucose-intolerance-diabetes-2017-66-1928-1938
#4
Guadalupe Navarro, Yassan Abdolazami, Zhengshan Zhao, Haixia Xu, Sooyeon Lee, Neali A Armstrong, Justin P Annes
No abstract text is available yet for this article.
October 10, 2017: Diabetes
https://www.readbyqxmd.com/read/28993341/insights-from-molecular-characterization-of-adult-patients-of-families-with-multigenerational-diabetes-mellitus
#5
Serena Pezzilli, Ornella Ludovico, Tommaso Biagini, Luana Mercuri, Federica Alberico, Eleonora Lauricella, Hamza Dallali, Daniele Capocefalo, Massimo Carella, Elide Miccinilli, Pamela Piscitelli, Maria Giovanna Scarale, Tommaso Mazza, Vincenzo Trischitta, Sabrina Prudente
Multigenerational diabetes of the adulthood is a mostly overlooked entity, simplistically comprised in the large basin of type 2 diabetes. The general aim we are pursuing in last years is to unravel the genetic causes of such form of diabetes. Identifying among families with multigenerational diabetes those carrying mutations in known monogenic diabetes genes is the first step to then concentrate on remaining pedigrees where to unravel new diabetogenes.Targeted Next Generation Sequencing of 27 monogenic diabetes-genes has been carried out in 55 family probands and identified mutations verified among their relatives by Sanger sequencing...
October 9, 2017: Diabetes
https://www.readbyqxmd.com/read/28993340/erratum-ddb1-mediated-cry1-degradation-promotes-foxo1-driven-gluconeogenesis-in-liver-diabetes-2017-66-2571-2582
#6
Xin Tong, Deqiang Zhang, Nicholas Charney, Ethan Jin, Kyle VanDommelon, Kenneth Stamper, Neil Gupta, Johnny Saldate, Lei Yin
No abstract text is available yet for this article.
October 9, 2017: Diabetes
https://www.readbyqxmd.com/read/28986399/objectively-measured-physical-activity-sedentary-behavior-and-genetic-predisposition-to-obesity-in-us-hispanics-latinos-results-from-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#7
Jee-Young Moon, Tao Wang, Tamar Sofer, Kari E North, Carmen R Isasi, Jianwen Cai, Marc D Gellman, Ashley E Moncrieft, Daniela Sotres-Alvarez, Maria Argos, Robert C Kaplan, Qibin Qi
Studies using self-reported data suggest gene-physical activity interaction on obesity, yet the influence of sedentary behavior, distinct from lack of physical activity, on genetic associations with obesity remains unclear. We analyzed interactions of accelerometer-measured moderate-to-vigorous physical activity (MVPA) and sedentary time with genetic variants on obesity among 9,645 US Hispanics/Latinos. An overall genetic risk score (GRS), central nervous system (CNS)-related GRS, and non-CNS GRS were calculated based on 97 BMI-associated SNPs...
October 6, 2017: Diabetes
https://www.readbyqxmd.com/read/28986398/inhibition-of-cdk5-promotes-%C3%AE-cell-differentiation-from-ductal-progenitors
#8
Ka-Cheuk Liu, Gunter Leuckx, Daisuke Sakano, Philip A Seymour, Charlotte L Mattsson, Linn Rautio, Willem Staels, Yannick Verdonck, Palle Serup, Shoen Kume, Harry Heimberg, Olov Andersson
Inhibition of notch signalling is known to induce differentiation of endocrine cells in zebrafish and mouse. After performing an unbiased in vivo screen of ∼2200 small molecules in zebrafish we identified an inhibitor of Cdk5 (roscovitine), which potentiated formation of β-cells along the intra-pancreatic duct during concurrent inhibition of notch signalling. We confirmed and characterized the effect with a more selective Cdk5 inhibitor, (R)-DRF053, which specifically increased the number of duct-derived β-cells without affecting their proliferation...
October 6, 2017: Diabetes
https://www.readbyqxmd.com/read/28982655/erratum-mediobasal-hypothalamic-sirt1-is-essential-for-resveratrol-s-effects-on-insulin-action-in-rats-diabetes-2011-60-2691-2700
#9
Colette M Knight, Roger Gutierrez-Juarez, Tony K T Lam, Isabel Arrieta-Cruz, Loli Huang, Gary Schwartz, Nir Barzilai, Luciano Rossetti
No abstract text is available yet for this article.
October 5, 2017: Diabetes
https://www.readbyqxmd.com/read/28982654/erratum-pathophysiological-mechanism-of-bone-loss-in-type-2-diabetes-involves-inverse-regulation-of-osteoblast-function-by-pgc-1%C3%AE-and-skeletal-muscle-atrogenes-adipor1-as-a-potential-target-for-reversing-diabetes-induced-osteopenia-diabetes-2015-64-2609-2623
#10
Mohd Parvez Khan, Abhishek Kumar Singh, Amit Arvind Joharapurkar, Manisha Yadav, Sonal Shree, Harish Kumar, Anagha Gurjar, Jay Sharan Mishra, Mahesh Chandra Tiwari, Geet Kumar Nagar, Sudhir Kumar, Ravishankar Ramachandran, Anupam Sharan, Mukul Rameshchandra Jain, Arun Kumar Trivedi, Rakesh Maurya, Madan Madhav Godbole, Jiaur Rahaman Gayen, Sabyasachi Sanyal, Naibedya Chattopadhyay
No abstract text is available yet for this article.
October 5, 2017: Diabetes
https://www.readbyqxmd.com/read/28982653/erratum-deletion-of-atf4-in-agrp-neurons-promotes-fat-loss-mainly-via-increasing-energy-expenditure-diabetes-2017-66-640-650
#11
Jiali Deng, Feixiang Yuan, Yajie Guo, Yuzhong Xiao, Yuguo Niu, Yalan Deng, Xiao Han, Youfei Guan, Shanghai Chen, Feifan Guo
No abstract text is available yet for this article.
October 5, 2017: Diabetes
https://www.readbyqxmd.com/read/28970284/stress-induced-microrna-708-impairs-%C3%AE-cell-function-and-growth
#12
Júlia Rodríguez-Comas, Alba Moreno-Asso, Juan Moreno-Vedia, Mercè Martín, Carlos Castaño, Anna Marzà-Florensa, Xavier Bofill-De Ros, Joan Mir-Coll, Joel Montané, Cristina Fillat, Rosa Gasa, Anna Novials, Joan-Marc Servitja
The pancreatic β-cell transcriptome is highly sensitive to external signals such as glucose oscillations and stress cues. MicroRNAs (miRNAs) have emerged as key factors in gene expression regulation. Here, we aimed to identify miRNAs that are modulated by glucose in mouse pancreatic islets. We identified miR-708 as the most upregulated miRNA in islets cultured at low glucose concentrations, a setting that triggers a strong stress response. miR-708 was also potently upregulated by triggering endoplasmic reticulum (ER) stress with thapsigargin and in islets of ob/ob mice...
October 2, 2017: Diabetes
https://www.readbyqxmd.com/read/28970283/dissociation-between-hormonal-counterregulatory-responses-and-cerebral-glucose-metabolism-during-hypoglycemia
#13
John J Lee, Nadia Khoury, Angela M Shackleford, Suzanne Nelson, Hector Herrera, Jo Ann Antenor-Dorsey, Katherine Semenkovich, Joshua S Shimony, William J Powers, Philip E Cryer, Ana María Arbeláez
Hypoglycemia is the most common complication of diabetes (DM), causing morbidity and death. Recurrent hypoglycemia alters the cascade of physiological and behavioral responses that maintain euglycemia. The extent to which these responses are normally triggered by decreased whole brain cerebral glucose metabolism (CMRglc) has not been resolved by previous studies. We measured plasma counterregulatory hormonal responses and whole brain CMRglc (along with blood-to-brain glucose transport rates and brain glucose concentrations) with 1-[(11)C]-D-glucose positron emission tomography during hyperinsulinemic glucose clamps at nominal plasma glucose concentrations of 90, 75, 60, and 45 mg/dL (5...
October 2, 2017: Diabetes
https://www.readbyqxmd.com/read/28970282/hyperlipidemia-induced-microrna-155-5p-improves-%C3%AE-cell-function-by-targeting-mafb
#14
Mengyu Zhu, Yuanyuan Wei, Claudia Geißler, Kathrin Abschlag, Judit Corbalán Campos, Michael Hristov, Julia Möllmann, Michael Lehrke, Ela Karshovska, Andreas Schober
A high-fat diet increases bacterial lipopolysaccharide (LPS) in the circulation, and thereby stimulates glucagon-like peptide-1 (GLP-1)-mediated insulin secretion by up-regulating interleukin (IL)-6. Although microRNA-155-5p (miR-155-5p), which increases IL-6 expression, is upregulated by LPS and hyperlipidemia, and patients with familial hypercholesterolemia less frequently develop diabetes, the role of miR-155-5p in the islet stress response to hyperlipidemia is unclear. Here, we demonstrate that hyperlipidemia-associated endotoxemia up-regulates miR-155-5p in murine pancreatic β-cells, which improved glucose metabolism and the adaptation of β-cells to obesity-induced insulin resistance...
September 29, 2017: Diabetes
https://www.readbyqxmd.com/read/28970281/rna-binding-protein-ybx2-regulates-rna-stability-during-cold-induced-brown-fat-activation
#15
Dan Xu, Shaohai Xu, Aung Maung Maung Kyaw, Yen Ching Lim, Sook Yoong Chia, Diana Teh Chee Siang, Juan R Alvarez-Dominguez, Peng Chen, Melvin Khee-Shing Leow, Lei Sun
Recent years have seen an upsurge of interest on brown adipose tissue (BAT) to combat the epidemic of obesity and diabetes. How its development and activation are regulated at the post-transcriptional level, however, has yet to be fully understood. RNA binding proteins (RBPs) lie in the center of post-transcriptional regulation. To systemically study the role of RBPs in BAT, we profiled >400 RBPs in different adipose depots and identified Y-box binding protein 2 (Ybx2) as a novel regulator in BAT activation...
September 29, 2017: Diabetes
https://www.readbyqxmd.com/read/28951389/genetically-determined-plasma-lipid-levels-and-risk-of-diabetic-retinopathy-a-mendelian-randomization-study
#16
Lucia Sobrin, Yong He Chong, Qiao Fan, Alfred Gan, Lynn K Stanwyck, Georgia Kaidonis, Jamie E Craig, Jihye Kim, Wen-Ling Liao, Yu-Chuen Huang, Wen-Jane Lee, Yi-Jen Hung, Xiuqing Guo, Yang Hai, Eli Ipp, Samuela Pollack, Heather Hancock, Alkes Price, Alan Penman, Paul Mitchell, Gerald Liew, Albert V Smith, Vilmundur Gudnason, Gavin Tan, Barbara E K Klein, Jane Kuo, Xiaohui Li, Mark W Christiansen, Bruce M Psaty, Kevin Sandow, Richard A Jensen, Ronald Klein, Mary Frances Cotch, Jie Jin Wang, Yucheng Jia, Ching J Chen, Yii-Der Ida Chen, Jerome I Rotter, Fuu-Jen Tsai, Craig L Hanis, Kathryn P Burdon, Tien Yin Wong, Ching-Yu Cheng
Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. We evaluated the causal relationship between plasma lipids and DR using a Mendelian randomization (MR) approach. We pooled genome-wide association studies summary statistics from 18 studies for 2 DR phenotypes: any DR (N=2,969 case; 4,096 controls) and severe DR, (N=1,277 cases; 3,980 controls). Previously identified lipid-associated single nucleotide polymorphisms (SNPs) served as instrumental variables...
September 26, 2017: Diabetes
https://www.readbyqxmd.com/read/28951388/retinal-microperimetry-a-new-tool-for-identifying-type-2-diabetic-patients-at-risk-of-developing-alzheimer%C3%A2-s-disease
#17
Andreea Ciudin, Olga Simó-Servat, Cristina Hernández, Gabriel Arcos, Susana Diego, Ángela Sanabria, Óscar Sotolongo, Isabel Hernández, Mercè Boada, Rafael Simó
Type 2 diabetes is associated with a high risk of cognitive impairment and dementia. Therefore, strategies aimed at identifying those patients at risk of dementia are needed. Given that the retina is a brain-derived tissue it may provide a non-invasive way of examining brain pathology. The aims of the study were to evaluate whether retinal sensitivity: 1) Correlates with the specific parameters of brain imaging related to cognitive impairment; 2) Discriminates diabetic patients with mild cognitive impairment (MCI) from those with normal cognition and Alzheimer's disease (AD)...
September 26, 2017: Diabetes
https://www.readbyqxmd.com/read/28935628/effect-of-exercise-induced-lactate-elevation-on-brain-lactate-levels-during-hypoglycemia-in-patients-with-type-1-diabetes-and-impaired-awareness-of-hypoglycemia
#18
Evita C Wiegers, Hanne M Rooijackers, Cees J Tack, Hans J M M Groenewoud, Arend Heerschap, Bastiaan E de Galan, Marinette van der Graaf
Since altered brain lactate handling has been implicated in the development of impaired awareness of hypoglycemia (IAH) in type 1 diabetes, the capacity to transport lactate into the brain during hypoglycemia may be relevant in its pathogenesis. High-intensity interval training (HIIT) increases plasma lactate levels. We compared the effect of HIIT-induced hyperlacticacidemia on brain lactate during hypoglycemia between 1) patients with type 1 diabetes and IAH, 2) patients with type 1 diabetes and normal awareness of hypoglycemia (NAH), and 3) healthy non-diabetic participants (n=6 per group)...
September 21, 2017: Diabetes
https://www.readbyqxmd.com/read/28931519/beta-cell-replacement-in-mice-using-human-type-1-diabetes-nuclear-transfer-embryonic-stem-cells
#19
Lina Sui, Nichole Danzl, Sean R Campbell, Ryan Viola, Damian Williams, Yuan Xing, Yong Wang, Neil Phillips, Greg Poffenberger, Bjarki Johannesson, Jose Oberholzer, Alvin C Powers, Rudolph L Leibel, Xiaojuan Chen, Megan Sykes, Dieter Egli
Beta cells derived from stem cells hold great promise for cell replacement therapy for diabetes. Here we examine the ability of nuclear transfer embryonic stem cells (NT-ES) derived from a type 1 diabetes patient to differentiate into beta cells, and provide a source of autologous islets for cell replacement. NT-ES cells differentiate in vitro with an average efficiency of 55% into C-peptide-positive cells, expressing markers of mature beta cells, including MAFA and NKX6.1. Upon transplantation in immunodeficient mice, grafted cells form vascularized islet-like structures containing MAFA/C-peptide-positive cells...
September 20, 2017: Diabetes
https://www.readbyqxmd.com/read/28928277/jnk-activation-of-bim-promotes-hepatic-oxidative-stress-steatosis-and-insulin-resistance-in-obesity
#20
Sara A Litwak, Lokman Pang, Sandra Galic, Mariana Igoillo-Esteve, William J Stanley, Jean-Valery Turatsinze, Kim Loh, Helen E Thomas, Arpeeta Sharma, Eric Trepo, Christophe Moreno, Daniel J Gough, Decio L Eizirik, Judy B de Haan, Esteban N Gurzov
The BCL-2 family are crucial regulators of the mitochondrial pathway of apoptosis in normal physiology and disease. Besides their role in cell death, BCL-2 proteins have been implicated in the regulation of mitochondrial oxidative phosphorylation and cellular metabolism. It remains unclear, however, whether these proteins have a physiological role in glucose homeostasis and metabolism in vivo Here we report that fat accumulation in the liver increases JNK-dependent BIM expression in hepatocytes. To determine the consequences of hepatic BIM deficiency in diet-induced obesity, we generated liver-specific BIM knockout (BLKO) mice...
September 19, 2017: Diabetes
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