journal
MENU ▼
Read by QxMD icon Read
search

Canadian Journal of Physiology and Pharmacology

journal
https://www.readbyqxmd.com/read/29244962/expression-of-the-frizzled-receptors-and-their-co-receptors-in-calcified-human-aortic-valves
#1
Ateeque Siddique, Bin Yu, Kashif Khan, Ryan Buyting, Hamood Al-Kindi, Hossny Alaws, Eric Rhéaume, Jean-Claude Tardif, Renzo Cecere, Adel Schwertani
The cellular mechanisms that induce calcific aortic stenosis are yet to be unravelled. Wnt signaling is increasingly being considered as a major player in the disease process. However, the presence of Wnt Frizzled receptors (Fzd) and co-receptors LRP5 and 6 in normal and diseased human aortic valves remains to be elucidated. Immunohistochemistry and qPCR were used to determine Fzd receptor expression in normal and calcified human aortic valve tissue, as well as human aortic valve interstitial cells (HAVICs) isolated from calcified and normal human aortic valves...
December 15, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29244961/time-dependent-therapeutic-roles-of-nitazoxanide-on-high-fat-diet-streptozotocin-induced-diabetes-in-rats-effects-on-hepatic-ppar-%C3%AE-receptors
#2
Samah Mohamed Elaidy, Mona A Hussain, Mohamed K El-Kherbetawy
Targeting Peroxisome Proliferator-Activated Receptor-gamma (PPAR-γ) is an approved strategy in facing insulin resistance (IR) for the diabetes mellitus (DM)-type 2. The PPAR-γ modulators display improvements in the insulin sensitizing and adverse effects of the traditional thiazolidinediones (TZDs). Nitazoxanide (NTZ) is proposed as a PPAR-γ receptor ligand, with agonistic post-transcriptional effects. Currently, NTZ-antidiabetic activities versus pioglitazone (PIO) in a high-fat diet/streptozotocin (HFD/STZ) rat model of type-2 diabetes was explored...
December 15, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29220591/cholinergic-and-cytoprotective-signaling-cascades-mediate-the-mitigative-effect-of-erythropoietin-on-acute-radiation-syndrome
#3
Shereen Mohamed Galal, Mohamed Khairy Abdel-Rafei, Hesham Hasan
The present investigation aimed to evaluate the radiomitigative efficacy of the recombinant human erythropoietin (rhEPO) against acute radiation syndrome (ARS) in a rat model. Rats were irradiated with a single sublethal dose of γ- radiation (7 Gy; total body irradiation; TBI) at the 1st day of experimental course, then received EPO (5000 IU/kg; i.p) 24 hrs post irradiation, rats were observed for 30 days of survival analysis. Administration of EPO improved 30 days survival, alleviated TBI- induced myelosuppression and pancytopenia, by augmenting lymphocytes and WBCs in the peripheral blood of rats, while bone marrow (BM) and spleen cellularity were restored...
December 8, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29216442/lycopene-depresses-glutamate-release-through-inhibition-of-voltage-dependent-ca-sup-2-sup-entry-and-protein-kinase-c-in-rat-cerebrocortical-nerve-terminals
#4
Cheng-Wei Lu, Chi-Feng Hung, Wei-Horng Jean, Tzu-Yu Lin, Shu-Kuei Huang, Su Jane Wang
Lycopene is a natural dietary carotenoid which was reported to exhibit neuroprotective profile. Considering that excitotoxicity and cell death induced by glutamate are involved in many brain disorders, the effect of lycopene on glutamate release in rat cerebrocortical nerve terminals and the possible mechanism involved in such effect was investigated. We observed here that lycopene inhibited 4-aminopyridine (4-AP)-evoked glutamate release and intrasynaptosomal Ca <sup>2+<sup> concentration elevation...
December 7, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29169010/oxidative-stress-burden-inhibits-spermatogenesis-in-adult-male-rats-testosterone-protective-effect
#5
Samy Makary, Mohamed Abdo, Ereny Fekry
In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MTX has been shown to induce oxidative stress and exhibit antiproliferative effects in the testes. Adult male rats received oral saline gavage (control group with no treatment), the potential protective agents (LET, GSE, or Tp) alone, MTX alone, or a combination of one of the potential protective agents and MTX...
November 23, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29131966/activation-of-the-central-melanocortin-system-in-rats-persistently-reduces-body-and-fat-mass-independently-of-caloric-reduction
#6
Isabelle Côté, Sara M Green, Drake Morgan, Christy Carter, Nihal Tümer, Philip James Scarpace
Recent evidence indicate that Melanotan II (MTII) reduces body mass independently of caloric reduction. Because MTII induces a transient hypophagia, caloric reduction is still considered a primary mechanism for MTII-mediated body mass loss. To examine the contribution of caloric reduction to long-term body mass loss in response to Melanotan II (MTII), we centrally infused MTII or vehicle in ad libitum fed (MTII and Control) animals in comparison to a group of animals that were pair-fed (PF) to the MTII group...
November 13, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29120676/glutamine-protection-in-an-experimental-model-of-acetaminophen-nephrotoxicity
#7
Marco Brovedan, Sara María Molinas, Gerardo Pisani, Liliana Alicia Monasterolo, Laura Trumper
Acetaminophen (APAP) is a widely prescribed analgesic - antipyretic drug. In the present work we studied the effects of glutamine (Gln) in an "in vivo" model of APAP-induced nephrotoxicity in male Wistar rats. Renal function, histological characteristics and Na+, K+ ATPase cortical abundance and distribution were analyzed. The appearance of HSP70 and actin in urine were also evaluated. Mieloperoxidase activity in cortical tissue was measured as an index of the inflammatory response. Gln administration 30 min before APAP protected from the renal functional and histological damage promoted by APAP...
November 9, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29120671/erythropoietin-reduces-collagen-deposition-after-myocardial-infarction-but-does-not-improve-cardiac-function
#8
Fernanda G Pessoa, Charles Mady, Keila C B Fonseca, Adriana M Oliveira-Fonoff, Vera M C Salemi, Mauricio R Jordao, Fabio Fernandes, Felix J A Ramires
Myocardial remodeling includes inappropriate collagen deposition in the interstitium. Erythropoietin (EPO) may have cardioprotective effects. We aimed to assess the role of EPO on myocardial remodeling during the chronic phase. We studied 60 Wistar rats divided into Control (CT), Control+EPO (CT+EPO), Infarcted+EPO (MI+EPO), and Infarcted (MI). The interstitial collagen volume fraction (ICVF) was quantified. Echocardiography was performed. We quantified ADMA and glutathione by ELISA, and RT-PCR to assess apoptosis and inflammation...
November 9, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29053935/capsaicin-the-pungent-principle-of-peppers-ameliorates-alcohol-induced-acute-liver-injury-in-mice-via-modulation-of-matrix-metalloproteinases
#9
Meghana Koneru, Bidya Dhar Sahu, Salma Mukhtar Mir, Halley Gora Ravuri, Madhusudana Kuncha, Jerald Mahesh Kumar, Eswar Kumar Kilari, Ramakrishna Sistla
Alcohol, the most common cause for hepatic injury, may further deteriorate the hepatic tissue when left unattended. Capsaicin, the pungent principle of chilli-peppers, possesses antioxidant and anti-inflammatory properties and is a proven dietary antioxidant in various ailments. However, its role in alcohol induced hepatic injury is unclear. In this study, we investigated the effects of capsaicin on the hepatic tissue of mice treated with alcohol. Acute liver injury was induced in mice by oral gavage of 5 doses of 10 ml/kg of 50% ethyl alcohol at an interval of 12 hours each...
October 20, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29028441/physiological-and-pharmacological-inductors-of-hsp70-enhance-the-anti-oxidative-defense-mechanisms-of-the-liver-and-pancreas-in-diabetic-rats
#10
Maja Dimitrovska, Mirsada Dervisevik, Natasa Cipanovska, Katerina Gerazova, Suzana Dinevska-Kjovkarovska, Biljana Miova
Heat preconditioning (HP) is a powerful adaptive and protective phenomenon and the heat stress proteins (HSPs) it produces are an important determinant for the development of diabetic complications. Aspirin has been reported to modulate heat shock response in different organisms through increased induction of HSPs and is also known to exert anti-oxidative and radical scavenging effects in diabetes. We estimated the effect of physiological [heat stress (HS), 45min / 41±0.5ºC)] and pharmacological (aspirin treatment) induction of HSP70 on several parameters of oxidative state in the pancreas and liver of diabetic rats...
October 13, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29028440/intracerebroventricular-infusion-of-an-angiotensin-at2-receptor-agonist-novokinin-aggravates-some-diabetes-mellitus-induced-alterations-in-wistar-rats
#11
Daniela Pechlivanova, Kiril Petrov, Petar Grozdanov, Zlatina Nenchovska, Jana Tchekalarova, Alexander Stoynev
Cumulative data suggest the significant role of the Renin - Angiotensin System in the development of the pathological consequences of diabetes mellitus (DM). Newly synthesized AT2 receptor agonists gained importance as a target for creating new antihypertensives. The aim of the present work was to study the effects of a peptide AT2 agonist Novokinin, infused intracerebroventricularly, on the consequences of the streptozotocin-induced type 1 DM (T1 DM) in Wistar rats. Food and water consumption, body weight, urine excretion (metabolic cages), motor activity (open field test), anxiety (elevated plus maze), nociception (paw pressure analgesimeter test), spatial memory (T-maze alternation test) and plasma levels of glucose and corticosterone (ELISA) were assessed two weeks after the T1 DM induction...
October 13, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29020462/syk-inhibitor-r406-down-regulates-inflammation-in-an-in-vitro-model-of-pseudomonas-aeruginosa-infection
#12
Alaa Alhazmi, Joshua Choi, Marina Ulanova
As Pseudomonas aeruginosa infections are characterized by strong inflammation of infected tissues anti-inflammatory therapies in combination with antibiotics have been considered for the treatment of associated diseases. Syk tyrosine kinase is an important regulator of inflammatory responses, and its specific inhibition was explored as a therapeutic option in several inflammatory conditions; however, this has not been studied in bacterial infections. We used a model of in vitro infection of human monocytic cell line THP-1 and lung epithelial cell line H292 with both wild type and flagella-deficient mutant of P...
October 11, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28977777/omega-3-polyunsaturated-fatty-acid-docosahexaenoic-acid-and-its-role-in-exhaustive-exercise-induced-changes-in-female-rat-ovulatory-cycle
#13
Abeer F Mostafa, Shereen M Samir, Reham M Nagib
INTRODUCTION: Exhaustive exercises can cause delayed menarche or menstrual cycle irregularities in female. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are incorporated into a wide range of benefits in many physiological systems. AIM OF WORK: aimed to assess the role of ω-3 PUFA docosahexaenoic acid (DHA) on the deleterious effects of exhaustive exercise on female reproductive system in rats. MATERIALS AND METHODS: virgin female rats were randomly divided into four groups (12 rats in each): Control group (C), Omega 3 (ω-3) group treated with DHA, exhaustive exercise group (Ex), and exhaustive exercised rats treated with DHA...
October 4, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28977772/caffeine-alters-emotion-and-emotional-responses-in-low-habitual-caffeine-consumers
#14
Grace E Giles, Alexander M Spring, Heather L Urry, Joseph M Moran, Caroline R Mahoney, Robin B Kanarek
Caffeine reliably increases emotional arousal, but it is unclear if and how it influences other dimensions of emotion such as emotional valence. These experiments documented whether caffeine influences emotion and emotion regulation choice and success. Low to abstinent caffeine consumers (maximum 100 mg/day) completed measures of state anxiety, positive and negative emotion, and salivary cortisol before, 45 minutes, and 75 minutes after consuming 400 mg caffeine or placebo. Participants also completed an emotion regulation choice task in which they chose to employ cognitive reappraisal or distraction in response to high and low intensity negative pictures (Experiment 1) or a cognitive reappraisal task, in which they employed cognitive reappraisal or no emotion regulation strategy in response to negative and neutral pictures (Experiment 2)...
October 4, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28977758/nh4cl-affects-the-expression-of-wnt-%C3%AE-catenin-pathway-in-hepatocytes
#15
Lu Bai, Jingjing Li, Xiaorui Liu, Shasha Li, Fulei Li, Yanling Chen, Zujiang Yu
We intend to explore whether NH4Cl influences the viability and regulates the expression of Wnt/β-catenin pathway in hepatocytes.The Chang liver cell line was used and culture with different concentrations of NH4Cl (2.5, 5, 10, 20, 40 and 50mM/l) for 12h, 24h and 48h, respectively. The viability of hepatocytes was detected by MTT assay. The mRNA and protein expression level was analyzed with qRT-PCR and Western blotting, respectively. NH4Cl concentration significantly affects the viability of hepatocytes. With the increase of NH4Cl concentration, the viability of hepatocytes was decreased, accordingly...
October 4, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28977756/hypersensitivity-reactions-to-lmwhs-different-patterns-of-cross-reactivity-in-three-patients-case-series-and-a-literature-review
#16
Danica Juricic Nahal, Ivana Cegec, Viktorija Erdeljic Turk, Ksenija Makar Ausperger, Iva Kraljickovic, Iveta Simic
Low molecular weight heparins (LMWH) are used for a variety of indications. The most common type of hypersensitivity reactions to LMWHs are delayed-type hypersensitivity reactions (DHR). Immediate-type hypersensitivity reactions (IHR) occur only sporadically. Cross-reactivity of different LMWHs is a common and unpredictable problem. We present two cases of patients who developed DHR to nadroparin and enoxaparin, respectively. The third case presents a patient who developed IHR to nadroparin. Skin tests confirmed the hypersensitivity in all cases...
October 4, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28968507/does-posttreatment-thymoquinone-reverse-high-dose-atorvastatin-induced-hepatic-oxidative-injury-in-rats
#17
Sherif M Sabry Hassan, Ahmer Razzaque, Zulfiqar Ahmad, Vanessa Pazdernik, Shaimaa Nasr Amin
Atorvastatin (ATO) was commonly used to lower blood cholesterol, but it caused harmful effects to organs, including the liver. Thymoquinone (TQ), a prominent constituent of Nigella sativa, has antioxidant, antiinflammatory, antiapoptotic, antimicrobial, and anticancer activity. The current study investigated the mechanism of ATO-induced hepatotoxicity, whether posttreatment TQ could reverse ATO-induced hepatic injury, and the mechanism of action of TQ as a hepatoprotective agent. Forty adult male Sprague Dawley rats were divided into 4 equal groups: control, TQ-treated, ATO-treated, and combined ATO/TQ-treated...
October 2, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28957639/serum-levels-of-chemerin-apelin-vaspin-and-omentin-1-in-obese-type-2-diabetic-egyptian-patients-with-coronary-artery-stenosis
#18
Tarek M K Motawi, Soliman G Mahdy, Maha M El-Sawalhi, Eman N Ali, Rania Farag A El-Telbany
Cardiovascular diseases (CVD) are the leading cause of death in the diabetic population. Obesity is a serious problem that has been linked with CVD and diabetes via a variety of adipokines. The aims of this study were to evaluate and correlate circulating chemerin, apelin, vaspin, and omentin-1 levels in obese type 2 diabetic Egyptian patients with coronary artery stenosis (CAS), and to assess their usefulness as noninvasive diagnostic biomarkers. Chemerin, apelin, vaspin, and omentin-1 levels were determined by enzyme immunoassay in coronary artery disease (CAD) I patients (45 non-obese, nondiabetic with CAS), CAD II patients (45 obese, diabetic with CAS), and 30 controls...
September 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29068744/special-issue-of-selected-papers-from-the-3rd-european-section-meeting-of-the-international-academy-of-cardiovascular-sciences-held-in-marseille-france-on-1-4-october-2016-num%C3%A3-ro-sp%C3%A3-cial-d-articles-s%C3%A3-lectionn%C3%A3-s-de-la-3-e-r%C3%A3-union-de-la-section-europ%C3%A3-enne
#19
https://www.readbyqxmd.com/read/28758414/modulation-of-n-methyl-d-aspartate-receptors-in-isolated-rat-heart
#20
Ivan Srejovic, Vladimir Zivkovic, Tamara Nikolic, Nevena Jeremic, Isidora Stojic, Jovana Jeremic, Dragan Djuric, Vladimir Jakovljevic
Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isolated rat heart. The hearts of Wistar albino rats were retrogradely perfused according to the Langendorff technique at a constant perfusion pressure. The experimental protocol for all experimental groups included the stabilization period, application of estimated substance for 5 min, followed by a washout period of 10 min...
November 2017: Canadian Journal of Physiology and Pharmacology
journal
journal
23586
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"