D E Korenchan, C Taglang, C von Morze, J E Blecha, J W Gordon, R Sriram, P E Z Larson, D B Vigneron, H F VanBrocklin, J Kurhanewicz, D M Wilson, R R Flavell
Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-(13)C,D10]diethylmalonic acid, which exhibits a large pH-dependent (13)C chemical shift over the physiological range. We demonstrate that co-polarization with [1-(13)C,D9]tert-butanol accurately measures pH via(13)C NMR and magnetic resonance spectroscopic imaging in phantoms.
March 21, 2017: Analyst