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Current Therapeutic Research, Clinical and Experimental

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https://www.readbyqxmd.com/read/30093925/investigating-tick-borne-flaviviral-like-particles-as-a-delivery-system-for-gene-therapy
#1
Anne H Neddermeyer, Kjell Hultenby, Maruthibabu Paidikondala, Ryan M Schuchman, Mehdi R M Bidokhti
Background: Research on the biogenesis of tick-borne encephalitis virus (TBEV) would benefit gene therapy. Due to specific arrangements of genes along the TBEV genome, its viral-like particles (VLPs) could be exploited as shuttles to deliver their replicon, which carries therapeutic genes, to immune system cells. Objective: To develop a flaviviral vector for gene delivery as a part of gene therapy research that can be expressed in secretable VLP suicidal shuttles and provide abundant unique molecular and structural data supporting this gene therapy concept...
2018: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/30069277/hyaluronic-acid-single-intra-articular-injection-in-knee-osteoarthritis-a-multicenter-open-prospective-study-art-one-75-with-placebo-post-hoc-comparison
#2
Dominique Baron, Christian Flin, Jérôme Porterie, Jacques Despaux, Patrice Vincent
Background: Viscosupplementation of the synovial liquid, by intra-articular injection of hyaluronic acid, is a widely used symptomatic treatment in knee osteoarthritis. Besides products designed for multi-injections (typically 3-5 injections at 1-week intervals), special interest is being given to single-injection products that offer specific advantages such as the reduction of the number of visits to the doctor and the number of invasive interventions with their associated risks. However, a question remains about the efficacy of these monoinjections, compared with the multi-injections regimens...
2018: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/30038671/efficacy-and-safety-profile-of-z-215-azeloprazole-sodium-a-proton-pump-inhibitor-compared-with-rabeprazole-sodium-in-patients-with-reflux-esophagitis-a-phase-ii-multicenter-randomized-double-blind-comparative-study
#3
Yoshikazu Kinoshita, Motoyasu Kusano, Katsuhiko Iwakiri, Mitsuhiro Fujishiro, Naoto Tachikawa, Ken Haruma
Background: The metabolism of many proton pump inhibitors is influenced by CYP2C19 genotype, which is a limitation of their use. Objectives: To determine the efficacy and safety profile of Z-215 (azeloprazole sodium) as initial treatment for reflux esophagitis (RE), dose response, and optimal dose compared with rabeprazole sodium (RPZ). Methods: We conducted an exploratory, multicenter, randomized, double-blind, parallel-group study in Japan...
2018: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29928468/tolerability-and-safety-profile-of-a-new-brand-generic-product-of-glatiramer-acetate-in-iranian-patients-with-relapsing-remitting-multiple-sclerosis-an-observational-cohort-study
#4
Roya Abolfazli, Shirin Pournourmohammadi, Ahmadreza Shamshiri, Sara Samadzadeh
Background: The aim of this study was to evaluate the safety, tolerability, and efficacy of a brand-generic glatiramer acetate product in patients with relapsing-remitting multiple sclerosis over a 12-month period. A noninterventional cohort study was conducted on 185 patients. The patients had a confirmed and documented diagnosis of relapsing-remitting multiple sclerosis as defined by the Revised McDonald Criteria (2010), were ambulatory with a Kurtzke Expanded Disability Status Scale score of 0 to 5...
2018: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29632620/experimental-hemorrhagic-shock-protocol-in-swine-models-the-effects-of-21-aminosteroid-on-the-small-intestine
#5
George Bouboulis, Vasileios G Bonatsos, Ageliki I Katsarou, Andreas Karameris, Antonis Galanos, Argyro Zacharioudaki, George Theodoropoulos, George Zografos, Apostolos E Papalois, Konstantinos Toutouzas
Background: The protective potential of lazaroids has been reported in previous studies on ischemia/reperfusion and induced hemorrhagic shock protocols. Objectives: The present study is the first experimental protocol on the effects of the antioxidant factor U-74389G on the small intestine of swine models in a hemorrhagic shock protocol and resuscitation with 3 different types of fluids. Methods: The study included 49 Landrace breed swine that were divided into groups of 7 each...
2018: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29276548/comparative-study-with-a-lip-balm-containing-0-5-propolis-special-extract-gh-2002-versus-5-aciclovir-cream-in-patients-with-herpes-labialis-in-the-papular-erythematous-stage-a-single-blind-randomized-two-arm-study
#6
Petr Arenberger, Monika Arenbergerova, Marie Hladíková, Simona Holcova, Bertram Ottillinger
Background and objectives: This controlled single-blind trial compared the efficacy of a lip balm with propolis special extract GH 2002 at a concentration of 0.5% in the treatment of episodes of herpes labialis with that of 5% aciclovir cream. Methods: Patients in the erythematous/papular stage were randomized: 189 patients were treated with propolis cream, 190 patients were treated with aciclovir cream (intention-to-treat population). Application was 5 times daily...
2018: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29234483/the-influence-of-emerging-markets-on-the-pharmaceutical-industry
#7
REVIEW
Maya Tannoury, Zouhair Attieh
Emerging markets represent an exceptional opportunity for the pharmaceutical industry. Although a precise definition is not yet available, economists define emerging markets as developing prosperous countries in which investment is expected to result in higher income despite high risks. Qualifying a market as emerging is not merely based on the economic status of the country, but also on several criteria that render the definition applicable to each country. Jim O'Neil, retired chairman of asset management at Goldman Sachs, identified leading economies of emerging markets: Brazil, Russia, India, and China (BRIC) and later Brazil, Russia, India, China, and South Africa (BRICS) and then Mexico, Indonesia, South Korea, and Turkey (MIST), which followed years later as the second tier of nations...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29234482/roads-to-health-in-developing-countries-understanding-the-intersection-of-culture-and-healing
#8
REVIEW
S Ibeneme, G Eni, A Ezuma, G Fortwengel
Background: The most important attribute to which all human beings aspire is good health because it enables us to undertake different forms of activities of daily living. The emergence of scientific knowledge in Western societies has enabled scientists to explore and define several parameters of health by drawing boundaries around factors that are known to influence the attainment of good health. For example, the World Health Organization defined health by taking physical and psychological factors into consideration...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29234481/in-defense-of-pharmaceutically-enhancing-human-morality
#9
Evangelos D Protopapadakis
Purpose: I will discuss the prospect of pharmaceutically enhancing human morality and decision making in such a way as to eliminate morally unjustifiable choices and promote desirable ones. Background: Our species in the relatively short period since it has emerged has enormously advanced in knowledge, science, and technical progress. When it comes to moral development, the distance it has covered is almost negligible. What if we could medically accelerate our moral development? What if we could once and for all render our species totally immune to certain vices? Methodology: I will examine whether pharmaceutically intervening in human morality would compromise the autonomy of moral agents...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29234480/which-benefits-are-mentioned-most-often-in-drug-development-publications
#10
Vanessa Strüver
Objectives: The aim was to identify theoretically expected as well as actually reported benefits from drug development and the importance of individual patient benefits compared to the collective benefits to society in general. Background: Ethical guidelines require that clinical research involving humans offer the potential for benefit. A number of characteristics can be applied to define research benefit. Often benefit is categorized as being either direct or indirect...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29234479/first-international-conference-on-health-research-hannover-germany
#11
EDITORIAL
Gerhard Fortwengel
No abstract text is available yet for this article.
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158856/intralesional-administration-of-human-recombinant-epidermal-growth-factor-improves-healing-and-reduces-amputations-in-patients-with-severe-diabetic-foot-ulcers
#12
Aristides L Garcia Herrera
No abstract text is available yet for this article.
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158855/clinical-evaluation-of-terap-c-vaccine-in-combined-treatment-with-interferon-and-ribavirin-in-patients-with-hepatitis-c
#13
Dorta Guridi Zaily, Castellanos Fernandez Marlen, Dueñas-Carrera Santiago, Martínez Donato Gillian, Valenzuela Silva Carmen, Cinza Estevez Zurina, Arús Soler Enrique R, Alvarez-Lajonchere Liz, González Fabián Lisset, Lazo Del Vallín Sacha, Ferrer Bataille Elena
Background: An estimated 170 million individuals worldwide are infected with the hepatitis C virus (HCV). Although treatment options using a combination of pegylated interferon and ribavirin (P-IFN/RBV) are available, sustained clearance of the virus is only achieved in approximately 40% of individuals infected with HCV genotype 1. Recent advances in the treatment of HCV using directly acting antiviral agents have been achieved; however, treatment can be very expensive and is associated with substantial side effects...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158854/current-condition-of-chronic-hepatitis-b-virus-infection-in-cuban-adults
#14
Castellanos Fernández Marlen Ivón, Dorta Guridi Zaily, Da Silva Conde-Eduardo Leda Patricia, Galbán García Enrique, Arús Soler Enrique, Martinez Pérez Yadina
Background: The reduction of the incidence of hepatitis B virus (HBV) infection in Cuba can be attributed to the effectiveness of the national immunization program. However, the number of patients with chronic HBV observed in clinical practice is not negligible. Objective: A cross-sectional study was conducted to describe the main clinical characteristics of patients with chronic hepatitis B virus infection. Methods: A total of 146 patients who had at least a 6-month history of hepatitis B surface antigen positivity were recruited between 2013 and 2015...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158853/diagnosis-and-treatment-of-autoimmune-liver-diseases-in-a-tertiary-referral-center-in-cuba
#15
Marlen Ivón Castellanos Fernández, Deyanira la Rosa Hernández, Diego Enrique Cabrera Eugenio, Wilson Palanca, Zaily Dorta Guridi, Licet González Fabián
Background: Autoimmune liver diseases (AILD) comprise a set of entities characterized by tissue damage as a result of the loss of self-tolerance. There are few reports of AILD from Caribbean countries. Objectives: The aim of our study was to investigate the clinical patterns, laboratory findings, and immunologic features, treatment responses, and prognoses of AILD in adult patients at a Cuban tertiary referral center. Methods: A prospective study was conducted at the National Institute of Gastroenterology in Havana, Cuba, from May 2012 to April 2016...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158852/curative-metatarsal-bone-surgery-combined-with-intralesional-administration-of-recombinant-human-epidermal-growth-factor-in-diabetic-neuropathic-ulceration-of-the-forefoot-a-prospective-open-uncontrolled-nonrandomized-observational-study
#16
Aristides L Garcia Herrera, Ridel de Jesús Febles Sanabria, Liliana de Los Ángeles Acosta Cabadilla, Miriam Moliner Cartaya
Background: Curative surgery is performed for a foot with ulcers and loss of protective sensation to heal the wound and prevent amputation. Evidence supports that patients with diabetes have decreased concentrations of growth factors in their tissues, notably epidermal growth factor (EGF). Injecting EGF deep into the bottom of the wound and its contours encourages a more effective response in terms of granulation tissue growth and wound closure. Objective: To assess the effectiveness and safety of curative metatarsal bone surgery combined with intralesional administration of human recombitant EGF in neuropathic diabetic forefoot ulceration...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158851/the-cuban-public-health-system-focuses-research-on-community-needs
#17
EDITORIAL
Roberto Cañete
No abstract text is available yet for this article.
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28912902/effects-of-dapagliflozin-on-body-composition-and-liver-tests-in-patients-with-nonalcoholic-steatohepatitis-associated-with-type-2-diabetes-mellitus-a-prospective-open-label-uncontrolled-study
#18
Hiroshi Tobita, Shuichi Sato, Tatsuya Miyake, Shunji Ishihara, Yoshikazu Kinoshita
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is an active form of nonalcoholic fatty liver disease. Risk factors for NASH include type 2 diabetes mellitus (T2DM) and obesity. Sodium-glucose cotransporter 2 (SGLT2) inhibitors used to treat T2DM prevent glucose reabsorption in the kidney and increase glucose urinary excretion. Dapagliflozin is a potent, selective SGLT2 inhibitor that reduces hyperglycemia in patients with T2DM and has been demonstrated to reduce some complications associated with NASH in rodent models...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28912901/can-a-selective-serotonin-reuptake-inhibitor-act-as-a-glutamatergic-modulator
#19
Marcos Emilio Frizzo
Sertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin reuptake inhibitors whose antidepressant mechanism of action is classically attributed to an elevation of the extracellular levels of serotonin in the synaptic cleft. However, the biological effects of these drugs seem to be more complex than their traditionally described mechanism of action. Among their actions is the inhibition of different types of Na(+) and K(+) channels, as well as of glutamate uptake activity. The clearance of extracellular glutamate is essential to maintain the central nervous system within physiological conditions, and this excitatory neurotransmitter is removed from the synaptic cleft by astrocyte transporters...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28912900/open-label-trial-of-the-efficacy-and-safety-profile-of-rikkunshito-used-for-the-treatment-of-gastrointestinal-symptoms-in-patients-with-parkinson-s-disease-a-pilot-study
#20
Koji Yakabi, Naomi Yamaguchi, Shino Ono, Norihito Yoshida, Eriko Hosomi, Kenjiro Hayashi, Mitsuko Ochiai, Kosuke Maezawa, Kyoichi Nomura
BACKGROUND: Patients with Parkinson's disease (PD) usually experience distress related not only to motor dysfunction, but also to nonmotor symptoms, including gastrointestinal dysfunction. OBJECTIVE: The purpose of this pilot study was to evaluate the efficacy and safety profile of a traditional Japanese medicine, rikkunshito (RKT), used for the treatment of gastrointestinal symptoms, associated with anorexia and dyspepsia, in patients with PD. METHODS: Patients were randomly assigned to either Group A (4-week treatment period with 7...
2017: Current Therapeutic Research, Clinical and Experimental
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