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Current Therapeutic Research, Clinical and Experimental

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https://www.readbyqxmd.com/read/28912902/effects-of-dapagliflozin-on-body-composition-and-liver-tests-in-patients-with-nonalcoholic-steatohepatitis-associated-with-type-2-diabetes-mellitus-a-prospective-open-label-uncontrolled-study
#1
Hiroshi Tobita, Shuichi Sato, Tatsuya Miyake, Shunji Ishihara, Yoshikazu Kinoshita
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is an active form of nonalcoholic fatty liver disease. Risk factors for NASH include type 2 diabetes mellitus (T2DM) and obesity. Sodium-glucose cotransporter 2 (SGLT2) inhibitors used to treat T2DM prevent glucose reabsorption in the kidney and increase glucose urinary excretion. Dapagliflozin is a potent, selective SGLT2 inhibitor that reduces hyperglycemia in patients with T2DM and has been demonstrated to reduce some complications associated with NASH in rodent models...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28912901/can-a-selective-serotonin-reuptake-inhibitor-act-as-a-glutamatergic-modulator
#2
Marcos Emilio Frizzo
Sertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin reuptake inhibitors whose antidepressant mechanism of action is classically attributed to an elevation of the extracellular levels of serotonin in the synaptic cleft. However, the biological effects of these drugs seem to be more complex than their traditionally described mechanism of action. Among their actions is the inhibition of different types of Na(+) and K(+) channels, as well as of glutamate uptake activity. The clearance of extracellular glutamate is essential to maintain the central nervous system within physiological conditions, and this excitatory neurotransmitter is removed from the synaptic cleft by astrocyte transporters...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28912900/open-label-trial-of-the-efficacy-and-safety-profile-of-rikkunshito-used-for-the-treatment-of-gastrointestinal-symptoms-in-patients-with-parkinson-s-disease-a-pilot-study
#3
Koji Yakabi, Naomi Yamaguchi, Shino Ono, Norihito Yoshida, Eriko Hosomi, Kenjiro Hayashi, Mitsuko Ochiai, Kosuke Maezawa, Kyoichi Nomura
BACKGROUND: Patients with Parkinson's disease (PD) usually experience distress related not only to motor dysfunction, but also to nonmotor symptoms, including gastrointestinal dysfunction. OBJECTIVE: The purpose of this pilot study was to evaluate the efficacy and safety profile of a traditional Japanese medicine, rikkunshito (RKT), used for the treatment of gastrointestinal symptoms, associated with anorexia and dyspepsia, in patients with PD. METHODS: Patients were randomly assigned to either Group A (4-week treatment period with 7...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761583/challenges-of-empirical-antibiotic-therapy-for-community-acquired-pneumonia-in-children
#4
REVIEW
Charlene M C Rodrigues
BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality globally, responsible for more than 14% of deaths in children younger than 5 years of age. Due to difficulties with pathogen identification and diagnostics of CAP in children, targeted antimicrobial therapy is not possible, hence the widespread use of empirical antibiotics, in particular penicillins, cephalosporin, and macrolides. OBJECTIVES: This review aimed to address medical, societal, and political issues associated with the widespread use of empirical antibiotics for CAP in the United Kingdom, India, and Nigeria...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761582/population-pharmacokinetic-characteristics-of-amikacin-in-suspected-cases-of-neonatal-sepsis-in-a-low-resource-african-setting-a-prospective-nonrandomized-single-site-study
#5
Seth K Amponsah, George O Adjei, Christabel Enweronu-Laryea, Kwasi A Bugyei, Kosta Hadji-Popovski, Jorgen A L Kurtzhals, Kim Kristensen
BACKGROUND: Amikacin exhibits marked pharmacokinetic (PK) variability and is commonly used in combination with other drugs in the treatment of neonatal sepsis. There is a paucity of amikacin PK information in neonates from low-resource settings. OBJECTIVES: To determine the PK parameters of amikacin, and explore the influence of selected covariates, including coadministration with aminophylline, on amikacin disposition in neonates of African origin. METHODS: Neonates with suspected sepsis admitted to an intensive care unit in Accra, Ghana, and treated with amikacin (15 mg/kg loading followed by 7...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761581/extended-release-guaifenesin-pseudoephedrine-hydrochloride-for-symptom-relief-in-support-of-a-wait-and-see-approach-for-the-treatment-of-acute-upper-respiratory-tract-infections-a-randomized-double-blind-placebo-controlled-study
#6
Edward J Septimus, Helmut H Albrecht, Gail Solomon, Tim Shea, Eric P Guenin
BACKGROUND: Despite the well-known fact that antibiotics (AB) are not effective against viruses, many patients ask for - and all too often doctors provide - AB for treating URTIs. Over-prescribing of AB is one of the key causes for the development of bacterial resistance, which the U.S. Centers for Disease Control and Prevention (CDC) calls "one of the world's most pressing public health problems". In addition to the CDC initiated "Get Smart About Antibiotics" campaign, focused on educating doctors the public about the importance of appropriate AB use, other programs tackling this problem include the development of new treatment paradigms...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761580/is-prostate-biopsy-recommended-in-turkish-men-with-a-prostate-specific-antigen-level-between-2-5-and-4-ng-ml
#7
Gokhan Koc, Hakan Turk, Mustafa Karabicak, Sitki Un, Batuhan Ergani, Rahmi Gokhan Ekin
BACKGROUND: Prostate cancer is the most common solid tumor. The incidence of prostate cancer shows regional and racial differences. The ideal PSA threshold for prostate biopsy is still being debated. OBJECTIVE: We aimed to investigate cancer detection rates in Turkish men who underwent transrectal ultrasound-guided prostate biopsy (TRUSPB) who had prostate-specific antigen (PSA) levels in the range of 2.5 to 4.0 ng/mL and compare them with the rates of cancer in patients with PSA levels in the range of 4...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761579/a-bayesian-approach-for-population-pharmacokinetic-modeling-of-alcohol-in-japanese-individuals
#8
Asuka Nemoto, Matsuura Masaaki, Kazue Yamaoka
BACKGROUND: Blood alcohol concentration data that were previously obtained from 34 healthy Japanese subjects with limited sampling times were reanalyzed. Characteristics of the data were that the concentrations were obtained from only the early part of the time-concentration curve. OBJECTIVE: To explore significant covariates for the population pharmacokinetic analysis of alcohol by incorporating external data using a Bayesian method, and to estimate effects of the covariates...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761578/esophageal-motility-and-rikkunshito-treatment-for-proton-pump-inhibitor-refractory-nonerosive-reflux-disease-a-prospective-uncontrolled-open-label-pilot-study-trial
#9
Takeo Odaka, Shigeru Yamato, Osamu Yokosuka
BACKGROUND: Only a few reports focused on esophageal motility in patients with proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) and there has been no established strategy for treatment. OBJECTIVE: To clarify the characteristics of esophageal motility in patients with PPI-refractory NERD, we evaluated esophageal function using combined multichannel intraluminal impedance and esophageal manometry (MII-EM). In addition, we evaluated the efficacy of rikkunshito (RKT), which is a gastrointestinal prokinetic agent...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761577/bleeding-risk-related-to-upper-gastrointestinal-endoscopic-biopsy-in-patients-receiving-antithrombotic-therapy-a-multicenter-prospective-observational-study
#10
Takafumi Yuki, Shunji Ishihara, Kazuo Yashima, Koichiro Kawaguchi, Hirofumi Fujishiro, Youichi Miyaoka, Mika Yuki, Yoshinori Kushiyama, Akiko Yasugi, Michiko Shabana, Koichirou Furuta, Kiwamu Tanaka, Masaharu Koda, Tetsuro Hamamoto, Yuichiro Sasaki, Hisao Tanaka, Teiji Yoshimura, Yoshikazu Murawaki, Hajime Isomoto, Yoshikazu Kinoshita
BACKGROUND: Although antithrombotic agents are widely used for cardiac and cerebrovascular disease prevention, they increase the risk of gastrointestinal (GI) bleeding. OBJECTIVE: To examine GI bleeding risk in association with an esophagogastroduodenoscopy (EGD) biopsy performed in patients without cessation of antithrombotic therapy. METHODS: This study was prospectively conducted at 14 centers. EGD biopsies were performed in patients receiving antithrombotic agents without cessation, as well as age- and sex-matched controls not receiving antithrombotic therapy...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761576/efficacy-and-safety-of-the-dipeptidyl-peptidase-4-inhibitor-sitagliptin-on-atherosclerosis-%C3%AE-cell-function-and-glycemic-control-in-japanese-patients-with-type-2-diabetes-mellitus-who-are-treatment-na%C3%A3-ve-or-poorly-responsive-to-antidiabetes-agents-a-multicenter
#11
Yuya Tsurutani, Masao Omura, Yoko Matsuzawa, Jun Saito, Mariko Higa, Matsuo Taniyama, Tetsuo Nishikawa
BACKGROUND: Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is widely used in patients with type 2 diabetes. However, the pleiotropic effects of sitagliptin is not well understood. OBJECTIVE: To assess the clinical efficacy and safety of sitagliptin on atherosclerosis, β-cell function, and glycemic control in Japanese patients with type 2 diabetes. METHODS: A prospective observational study of 270 patients with type 2 diabetes mellitus was carried out...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761575/chemical-stability-of-ceftolozane-tazobactam-in-polyvinylchloride-bags-and-elastomeric-pumps
#12
Joseph Terracciano, Elizabeth G Rhee, Jacqueline Walsh
BACKGROUND: Elastomeric pumps are often used to administer intravenous antibiotics in the outpatient setting, but effective infusion requires that the drug remain stable in solution throughout the procedure. OBJECTIVE: To determine the chemical stability of ceftolozane/tazobactam when reconstituted and stored over an extended time in the AccuFlo (EMED Technologies, El Dorado Hills, California) and I-Flow Homepump Eclipse (Halyard, Alpharetta, Georgia) elastomeric pumps compared with the results of the label-supporting studies in polyvinylchloride (PVC) bags...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761574/repurposed-therapeutic-agents-targeting-the-ebola-virus-a-systematic-review
#13
Hussein Sweiti, Obinna Ekwunife, Thomas Jaschinski, Stefan K Lhachimi
BACKGROUND: The Ebola virus has been responsible for numerous outbreaks since the 1970s, with the most recent outbreak taking place between 2014 and 2016 and causing an international public health emergency. Ebola virus disease (EVD) has a high mortality rate and no approved targeted treatment exists to date. A number of established drugs are being considered as potential therapeutic agents for the treatment of EVD. OBJECTIVE: We aimed to identify potential drug repositioning candidates and to assess the scientific evidence available on their efficacy...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761573/safety-efficacy-and-bioavailability-of-fixed-dose-combinations-in-type-2-diabetes-mellitus-a-systematic-updated-review
#14
REVIEW
Thangavel Mahalingam Vijayakumar, Jayasutha Jayram, Vishnu Meghana Cheekireddy, Dasari Himaja, Yalamanchili Dharma Teja, Damodharan Narayanasamy
PURPOSE: Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance. As time progresses, monotherapy often does not provide effective glycemic control, generating the need for an add-on therapy. Hence, multiple oral hypoglycemic agents formulated as a single-dose form called fixed-dose combinations (FDCs) play an essential role in glycemic control. The purpose of this systematic review is to appraise the recently published evidence on the safety, efficacy, and bioavailability of FDCs...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28761572/a-case-of-severe-iron-deficiency-anemia-associated-with-long-term-proton-pump-inhibitor-use
#15
REVIEW
David N Dado, Erin B Loesch, Sudha P Jaganathan
The use of proton pump inhibitors (PPIs) in the treatment of gastrointestinal diseases has evolved over recent years. Initially intended for short-term use, PPIs are increasingly being used, often inappropriately, as long-term maintenance medications. The mechanism of action of PPIs is suppression of gastric basal and stimulated acid secretion by inhibiting the parietal cell H(+)/K(+) ATP pump with a resultant increase in gastric pH and hypo- or achlorhydria. Although short-term use is related to few adverse effects, long-term use is associated with numerous complications...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28119763/evaluation-of-the-efficacy-and-safety-of-vonoprazan-in-patients-with-nonerosive-gastroesophageal-reflux-disease-a-phase-iii-randomized-double-blind-placebo-controlled-multicenter-study
#16
Yoshikazu Kinoshita, Yuuichi Sakurai, Madoka Shiino, Kentaro Kudou, Akira Nishimura, Takuya Miyagi, Katsuhiko Iwakiri, Eiji Umegaki, Kiyoshi Ashida
BACKGROUND: For many patients, current treatments do not adequately resolve heartburn in nonerosive reflux disease (NERD). OBJECTIVE: To compare vonoprazan and placebo with respect to the frequency and severity of heartburn in patients with NERD. METHODS: This Phase III, double-blind, placebo-controlled, parallel-group, multicenter study included patients in Japan aged ≥20 years with Grade N or M NERD and recurrent acid reflux symptoms. Patients were blinded and randomized 1:1:1 to receive placebo or vonoprazan 10 mg or 20 mg...
2016: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28066515/a-multicenter-randomized-open-label-trial-efficacy-of-once-daily-versus-twice-daily-double-dose-rabeprazole-on-refractory-gastroesophageal-reflux-disease-related-symptoms-and-quality-of-life
#17
Akira Mizuki, Masayuki Tatemichi, Terue Sakakibara, Yukihiko Miura, Shigeyuki Zeki, Mitsuru Ohata, Kenji Matsuo, Fumio Kawamura, Hiroshi Nagata
BACKGROUND: Approximately 20% to 40% of patients with gastroesophageal reflux disease (GERD) are refractory to standard-dose proton-pump inhibitor (PPI) treatment. OBJECTIVE: We compared the efficacy and quality-of-life effects of 20 mg once daily (QD) versus 10 mg twice daily (BID) rabeprazole (RPZ) in patients with refractory GERD-related symptoms and sleep disturbances. METHODS: This multicenter, prospective, randomized, open-label study included patients in whom PPI treatment >4 weeks was ineffective...
2016: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28053674/a-3-arm-randomized-trial-for-achilles-tendinopathy-eccentric-training-eccentric-training-plus-a-dietary-supplement-containing-mucopolysaccharides-or-passive-stretching-plus-a-dietary-supplement-containing-mucopolysaccharides
#18
Ramon Balius, Guillermo Álvarez, Fernando Baró, Fernando Jiménez, Carles Pedret, Ester Costa, Daniel Martínez-Puig
BACKGROUND: Tendinopathy is an overuse tendon injury that occurs in loaded tendons and results in pain and functional impairment. Although many treatments for painful tendons are described, the scientific evidence for most of the conservative and surgical treatments is not always conclusive. OBJECTIVES: This study was designed to evaluate the efficacy of 3 different interventions in patients with Achilles tendinopathy. The interventions include the combination of 2 physical therapy programs (eccentric training [EC] or passive stretching [PS]) with a supplement containing mucopolisaccharides...
2016: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/27766122/preclinical-evaluation-of-tolerability-of-a-selective-bacteriostatic-locally-active-vaginal-formulation
#19
Luca Ivan Ardolino, Marisa Meloni, Giuseppe Brugali, Emanuela Corsini, Corrado Lodovico Galli
BACKGROUND: Polybactum (Effik International, Brussels, Belgium) is a vaginal mucoadhesive product (medical device) designed to form a film that acts as a mechanical barrier with the aim of inhibiting colonization by specific pathogens. It contains polycarbophil, a bioadhesive agent, and lauryl glucoside (LG), a nonionic surfactant that reinforces the barrier effect through its tensioactive properties. OBJECTIVE: To assess the local safety profile, tolerability, and efficacy of Polybactum formulations...
2016: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/27668025/a-novel-topical-combination-ointment-with-antimicrobial-activity-against-methicillin-resistant-streptococcus-aureus-gram-negative-superbugs-yeasts-and-dermatophytic-fungi
#20
Kenneth S Thomson, Gina K Thomson, John Biehle, Andrew Deeb, Jamaal Crawford, R Herrera
BACKGROUND: The use of topical antimicrobial agents for management of minor skin infections is a clinical strategy that is commonly practiced in the community. Coupled with the use of topical antimicrobial agents is the emergence of antibiotic-resistant strains of pathogens leading to the need for alternative treatments. OBJECTIVE: A novel topical combination ointment consisting of salicylic acid, oak bark extract, benzoic acid, and polyethylene glycol (Bensal HP, Sonar products Inc...
2016: Current Therapeutic Research, Clinical and Experimental
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