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Current Therapeutic Research, Clinical and Experimental

Yoshikazu Kinoshita, Yuuichi Sakurai, Madoka Shiino, Kentaro Kudou, Akira Nishimura, Takuya Miyagi, Katsuhiko Iwakiri, Eiji Umegaki, Kiyoshi Ashida
BACKGROUND: For many patients, current treatments do not adequately resolve heartburn in nonerosive reflux disease (NERD). OBJECTIVE: To compare vonoprazan and placebo with respect to the frequency and severity of heartburn in patients with NERD. METHODS: This Phase III, double-blind, placebo-controlled, parallel-group, multicenter study included patients in Japan aged ≥20 years with Grade N or M NERD and recurrent acid reflux symptoms. Patients were blinded and randomized 1:1:1 to receive placebo or vonoprazan 10 mg or 20 mg...
2016: Current Therapeutic Research, Clinical and Experimental
Akira Mizuki, Masayuki Tatemichi, Terue Sakakibara, Yukihiko Miura, Shigeyuki Zeki, Mitsuru Ohata, Kenji Matsuo, Fumio Kawamura, Hiroshi Nagata
BACKGROUND: Approximately 20% to 40% of patients with gastroesophageal reflux disease (GERD) are refractory to standard-dose proton-pump inhibitor (PPI) treatment. OBJECTIVE: We compared the efficacy and quality-of-life effects of 20 mg once daily (QD) versus 10 mg twice daily (BID) rabeprazole (RPZ) in patients with refractory GERD-related symptoms and sleep disturbances. METHODS: This multicenter, prospective, randomized, open-label study included patients in whom PPI treatment >4 weeks was ineffective...
2016: Current Therapeutic Research, Clinical and Experimental
Ramon Balius, Guillermo Álvarez, Fernando Baró, Fernando Jiménez, Carles Pedret, Ester Costa, Daniel Martínez-Puig
BACKGROUND: Tendinopathy is an overuse tendon injury that occurs in loaded tendons and results in pain and functional impairment. Although many treatments for painful tendons are described, the scientific evidence for most of the conservative and surgical treatments is not always conclusive. OBJECTIVES: This study was designed to evaluate the efficacy of 3 different interventions in patients with Achilles tendinopathy. The interventions include the combination of 2 physical therapy programs (eccentric training [EC] or passive stretching [PS]) with a supplement containing mucopolisaccharides...
2016: Current Therapeutic Research, Clinical and Experimental
Luca Ivan Ardolino, Marisa Meloni, Giuseppe Brugali, Emanuela Corsini, Corrado Lodovico Galli
BACKGROUND: Polybactum (Effik International, Brussels, Belgium) is a vaginal mucoadhesive product (medical device) designed to form a film that acts as a mechanical barrier with the aim of inhibiting colonization by specific pathogens. It contains polycarbophil, a bioadhesive agent, and lauryl glucoside (LG), a nonionic surfactant that reinforces the barrier effect through its tensioactive properties. OBJECTIVE: To assess the local safety profile, tolerability, and efficacy of Polybactum formulations...
2016: Current Therapeutic Research, Clinical and Experimental
Kenneth S Thomson, Gina K Thomson, John Biehle, Andrew Deeb, Jamaal Crawford, R Herrera
BACKGROUND: The use of topical antimicrobial agents for management of minor skin infections is a clinical strategy that is commonly practiced in the community. Coupled with the use of topical antimicrobial agents is the emergence of antibiotic-resistant strains of pathogens leading to the need for alternative treatments. OBJECTIVE: A novel topical combination ointment consisting of salicylic acid, oak bark extract, benzoic acid, and polyethylene glycol (Bensal HP, Sonar products Inc...
2016: Current Therapeutic Research, Clinical and Experimental
Spencer C Greene, Patrick K Noonan, Carlos Sanabria, W Frank Peacock
BACKGROUND: Oral solution N-acetylcysteine (NAC) is an antidote for acetaminophen overdose, but its unpleasant taste and aroma can impede delivery even after the coadministration of antiemetic medications. Flavored effervescent NAC tablets dissolved in water might be a more palatable formulation than oral solution NAC diluted with soft drink. OBJECTIVES: To evaluate the relative bioavailability of these 2 formulations and assess subjective preferences between them...
2016: Current Therapeutic Research, Clinical and Experimental
Roberto Cañete
No abstract text is available yet for this article.
2016: Current Therapeutic Research, Clinical and Experimental
Mika Yuki, Yoshinori Komazawa, Yoshiya Kobayashi, Maho Kusunoki, Yoshiko Takahashi, Sayaka Nakashima, Goichi Uno, Isao Ikuma, Toshihiro Shizuku, Yoshikazu Kinoshita
BACKGROUND: Daikenchuto (DKT), a traditional Japanese herbal medicine, is widely used for treatment of gastrointestinal disorders. We evaluated the efficacy and safety of DKT for abdominal bloating in patients with chronic constipation. OBJECTIVE: To evaluate the efficacy and safety of DKT for the treatment of abdominal bloating. METHODS: After discontinuing as-needed use of laxatives, 10 patients received oral DKT for 14 days (15 g/d). To evaluate small intestinal bacteria overgrowth (SIBO), a glucose breath test was performed before and after treatment with DKT...
December 2015: Current Therapeutic Research, Clinical and Experimental
D Hamish Wright, Ramon Mols, Kevin R Brown, Geng-Chang Yeh, Eric Woolf, Lisa Hickey, Stefan Zajic
OBJECTIVE: This study was designed to demonstrate that alendronate (ALN)/vitamin D3 combination tablets (ALN/D5600) are bioequivalent to corresponding doses of ALN and vitamin D3 as individual tablets in healthy Taiwanese volunteers. METHODS: In this open-label, randomized, 2-period, crossover study, 68 volunteers were randomized to a single ALN/D5600 combination tablet or corresponding doses of 70 mg ALN + 5600 IU vitamin D3 (2 × 2800 IU), followed by a 12-day washout period and administration of the alternate formulation...
December 2015: Current Therapeutic Research, Clinical and Experimental
Samantha L Price, James S Minnion, Stephen R Bloom
AIMS: To investigate the effect of Glu-3 OXM-like analogues on food intake and bodyweight in male rats. BACKGROUND: Oxyntomodulin (OXM) is a natural agonist at both the glucagon receptor (GCGr) and the glucagon-like peptide 1 receptor (GLP-1r), and peripheral administration reduces food intake and increases energy expenditure in rodents and humans. Substituting the native glutamine (Gln) at amino acid position 3 of OXM for glutamate (Glu) has previously been shown to diminish GCGr activity without affecting GLP-1r activity...
December 2015: Current Therapeutic Research, Clinical and Experimental
Zhengtian Gu, Carlos Parra, Anissa Wong, Alice Nguyen, Ronnie Cheung, Thomas Catalano
OBJECTIVE: The post-reconstitution chemical stability and microbial challenge hold time of nonpreserved telavancin for injection was determined using common reconstitution diluents and intravenous (IV) infusion solutions stored at room temperature with light (ambient) or at 2°C to 8°C without light (refrigeration). METHODS: Telavancin was reconstituted with 5% dextrose, 0.9% normal saline, or sterile water (15 mg/mL). Infusion solutions at 0.6 and 8.0 mg/mL were prepared in ViaFlex (polyvinyl chloride) IV bags (Baxter International Inc, Deerfield, Illinois) using 5% dextrose, 0...
December 2015: Current Therapeutic Research, Clinical and Experimental
Patrick Sand, Traci Aladeen, Paul Kirkegaard, Dennis LaChance, Christine Slover
BACKGROUND: VIBATIV is a once-daily, injectable lipoglycopeptide antibiotic approved in the U.S. for the treatment of hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) caused by susceptible isolates of Staphylococcus aureus when alternative treatments are not suitable. In addition, VIBATIV is approved in the U.S. for the treatment of adult patients with complicated skin & skin structure infections (cSSSI) caused by susceptible isolates of Gram-positive bacteria, including Staphylococcus aureus, both methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) strains...
December 2015: Current Therapeutic Research, Clinical and Experimental
Bao-Xin Ma, Jie Li, Hua Li, Sui-Sheng Wu
OBJECTIVE: To investigate the potential mechanisms underlying the protective effects of recombinant human erythropoietin (rhEPO) and carbamylated EPO (CEPO) against myocardial cell apoptosis in epilepsy. METHODS: Rats were given an intra-amygdala injection of kainic acid to induce epilepsy. Groups of rats were treated with rhEPO or CEPO before induction of epilepsy, whereas additional rats were given a caudal vein injection of AG490, a selective inhibitor of Janus kinase 2 (JAK2)...
December 2015: Current Therapeutic Research, Clinical and Experimental
Majed M Masadeh, Karem H Alzoubi, Omar F Khabour, Sayer I Al-Azzam
BACKGROUND: Ciprofloxacin is a commonly used antibiotic for urinary tract infection that interacts with bacterial topoisomerases leading to oxidative radicals generation and bacterial cell death. Phosphodiesterase inhibitors (PDEis), on the other hand, are commonly used drugs for the management of erectile dysfunction. The group includes agents such as sildenafil, vardenafil, and tadalafil. OBJECTIVES: We investigated whether PDEi could interfere with the antibacterial activity of ciprofloxacin...
December 2015: Current Therapeutic Research, Clinical and Experimental
Tsuyoshi Ebihara, Shinji Oshima, Mitsuyoshi Okita, Sayumi Shiina, Akio Negishi, Kousuke Ohara, Shigeru Ohshima, Hiroyuki Iwasaki, Akira Yoneyama, Eiji Kitazumi, Daisuke Kobayashi
BACKGROUND: Pneumonia is the most common cause of death in patients with severe motor and intellectual disabilities (SMID), and intravenous ceftazidime (CAZ) is a widely used treatment for such infections. However, intravenous administration in patients with SMID may be difficult because of insufficient vascular development. OBJECTIVES: The aim of our study was to determine the feasibility of subcutaneous drug administration by mentholated warm compresses (WMCs) as an alternative delivery method for ceftazidime in patients with SMID...
December 2015: Current Therapeutic Research, Clinical and Experimental
Stefano Gonnelli, Carla Caffarelli, Kostantinos Stolakis, Claudia Cuda, Nicola Giordano, Ranuccio Nuti
BACKGROUND: Statins are at the forefront of strategies to manage hypercholesterolemia. However 10% to 15% of patients are intolerant to any statin drugs, even at low daily doses and almost one-third of statin users discontinue therapy within 1 year. Some nutraceuticals are prescribed as lipid-lowering substances, but doubts remain about their efficacy and tolerability. OBJECTIVES: We aimed to investigate the efficacy and the safety of a nutraceutical combination consisting mainly of 200 mg red yeast rice extract (equivalent to 3 mg monacolins), 500 mg berberine, and 10 mg policosanols (MBP-NC) in patients with low-moderate risk hypercholesterolemia...
December 2015: Current Therapeutic Research, Clinical and Experimental
Sudha S Shankar, R Ravi Shankar, Radha A Railkar, Chan R Beals, Helmut O Steinberg, David E Kelley
BACKGROUND: Insulin resistance heightens the risk for type 2 diabetes mellitus and cardiovascular disease. Amelioration of insulin resistance may reduce this risk. The thiazolidinedone class of insulin sensitizers improves insulin action in individuals with insulin-resistant diabetes and nondiabetic individuals. However, there are few reports on the time of onset of such effects independent of reversal of glucotoxicity. OBJECTIVE: The goal of our study was to test whether the thiazolidinedione pioglitazone has prominent early metabolic effects that can be detected in an obese, nondiabetic, insulin-resistant population...
December 2015: Current Therapeutic Research, Clinical and Experimental
Jeremy Fields, Jorge T Go, Konrad S Schulze
BACKGROUND: Pills (tablets and capsules) are widely used to administer prescription drugs or to take supplements such as vitamins. Unfortunately, little is known about how much effort it takes Americans to swallow these various pills. More specifically, it is not known to what extent hard-to-swallow pills might affect treatment outcomes (eg, interfering with adherence to prescribed medications or causing clinical complications). It is also unclear which properties (eg, size, shape, or surface texture) Americans prefer or reject for their pills...
December 2015: Current Therapeutic Research, Clinical and Experimental
Attalla Farag El-Kott, Mashael Mohammed Bin-Meferij
BACKGROUND: Severe destructive hepatic injuries can be induced by acetaminophen overdose and may lead to acute hepatic failure. OBJECTIVE: To investigate the ameliorative effects of Arctium lappa root extract on acetaminophen-induced hepatotoxicity. METHODS: Rats were divided into 4 groups: normal control group, Arctium lappa extract group, acetaminophen-injected group, and acetaminophen treated with Arctium lappa extract group. RESULTS: The treatment with Arctium lappa extract reduced serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase in the acetaminophen group when compared with the control group...
December 2015: Current Therapeutic Research, Clinical and Experimental
Karel Rauš, Stephan Pleschka, Peter Klein, Roland Schoop, Peter Fisher
BACKGROUND: Echinacea has antiviral activity against influenza viruses in vitro and has traditionally been used for treatment of colds and flu. OBJECTIVES: This randomized, double-blind, double-dummy, multicenter, controlled clinical trial compared a new echinacea formulation with the neuraminidase inhibitor oseltamivir, the gold standard treatment for influenza. METHODS: Following informed consent, 473 patients with early influenza symptoms (≤48 hours) were recruited in primary care in the Czech Republic and randomized to either 5 days of oseltamivir followed by 5 days of placebo, or 10 days of an Echinacea purpurea-based formulation called Echinaforce Hotdrink (A...
December 2015: Current Therapeutic Research, Clinical and Experimental
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