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Brain: a Journal of Neurology

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https://www.readbyqxmd.com/read/30423029/local-structural-connectivity-is-associated-with-social-cognition-in-autism-spectrum-disorder
#1
Marc-Antoine d'Albis, Pamela Guevara, Miguel Guevara, Charles Laidi, Jennifer Boisgontier, Samuel Sarrazin, Delphine Duclap, Richard Delorme, Federico Bolognani, Christian Czech, Céline Bouquet, Myriam Ly-Le Moal, Stefan Holiga, Anouck Amestoy, Isabelle Scheid, Alexandru Gaman, Marion Leboyer, Cyril Poupon, Jean-François Mangin, Josselin Houenou
The current theory implying local, short-range overconnectivity in autism spectrum disorder, contrasting with long-range underconnectivity, is based on heterogeneous results, on limited data involving functional connectivity studies, on heterogeneous paediatric populations and non-specific methodologies. In this work, we studied short-distance structural connectivity in a homogeneous population of males with high-functioning autism spectrum disorder and used a novel methodology specifically suited for assessing U-shaped short-distance tracts, including a recently developed tractography-based atlas of the superficial white matter fibres...
November 13, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30423015/a-novel-atp1a2-mutation-in-a-patient-with-hypokalaemic-periodic-paralysis-and-cns-symptoms
#2
Marisol Sampedro Castañeda, Edmar Zanoteli, Renata S Scalco, Vinicius Scaramuzzi, Vitor Marques Caldas, Umbertina Conti Reed, Andre Macedo Serafim da Silva, Benjamin O'Callaghan, Rahul Phadke, Enrico Bugiardini, Richa Sud, Samuel McCall, Michael G Hanna, Hanne Poulsen, Roope Männikkö, Emma Matthews
Hypokalaemic periodic paralysis is a rare genetic neuromuscular disease characterized by episodes of skeletal muscle paralysis associated with low serum potassium. Muscle fibre inexcitability during attacks of paralysis is due to an aberrant depolarizing leak current through mutant voltage sensing domains of either the sarcolemmal voltage-gated calcium or sodium channel. We report a child with hypokalaemic periodic paralysis and CNS involvement, including seizures, but without mutations in the known periodic paralysis genes...
November 12, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30418586/how-right-hemisphere-damage-after-stroke-can-impair-speech-comprehension
#3
Andrea Gajardo-Vidal, Diego L Lorca-Puls, Thomas M H Hope, Oiwi Parker Jones, Mohamed L Seghier, Susan Prejawa, Jennifer T Crinion, Alex P Leff, David W Green, Cathy J Price
Acquired language disorders after stroke are strongly associated with left hemisphere damage. When language difficulties are observed in the context of right hemisphere strokes, patients are usually considered to have atypical functional anatomy. By systematically integrating behavioural and lesion data from brain damaged patients with functional MRI data from neurologically normal participants, we investigated when and why right hemisphere strokes cause language disorders. Experiment 1 studied right-handed patients with unilateral strokes that damaged the right (n = 109) or left (n = 369) hemispheres...
November 9, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30403785/early-microglial-activation-and-peripheral-inflammation-in-dementia-with-lewy-bodies
#4
Ajenthan Surendranathan, Li Su, Elijah Mak, Luca Passamonti, Young T Hong, Robert Arnold, Patricia Vázquez Rodríguez, William R Bevan-Jones, Susannah A E Brain, Tim D Fryer, Franklin I Aigbirhio, James B Rowe, John T O'Brien
Inflammation is increasingly recognized as part of the pathology of neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, but its role in dementia with Lewy bodies remains unclear. Using multimodal imaging and peripheral cytokine analysis, we therefore investigated central and peripheral inflammation in this common form of dementia. Nineteen participants with probable dementia with Lewy bodies and 16 similarly aged controls underwent 3 T MRI and PET imaging with 11C-PK11195, a marker of microglial activation in vivo...
November 6, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30380022/erratum
#5
(no author information available yet)
No abstract text is available yet for this article.
October 30, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30364932/reply-tdp-43-mutations-increase-hnrnp-a1-7b-through-gain-of-splicing-function
#6
Martine Tétreault, Jade-Emmanuelle Deshaies, Sabrina Semmler, Hadjara Sidibé, Lulzim Shkreta, Kathryn Volkening, Hermona Soreq, Michael J Strong, Benoit Chabot, Christine Vande Velde
No abstract text is available yet for this article.
October 25, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30364928/tdp-43-mutations-increase-hnrnp-a1-7b-through-gain-of-splicing-function
#7
Prasanth Sivakumar, Francesca De Giorgio, Agnieszka M Ule, Jacob Neeves, Remya R Nair, Matthew Bentham, Nicol Birsa, Jack Humphrey, Vincent Plagnol, Abraham Acevedo-Arozena, Thomas J Cunningham, Elizabeth M C Fisher, Pietro Fratta
No abstract text is available yet for this article.
October 25, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30358821/cognitive-control-involves-theta-power-within-trials-and-beta-power-across-trials-in-the-prefrontal-subthalamic-network
#8
Baltazar Zavala, Anthony Jang, Michael Trotta, Codrin I Lungu, Peter Brown, Kareem A Zaghloul
There is increasing evidence that the medial prefrontal cortex participates in conflict and feedback monitoring while the subthalamic nucleus adjusts actions. Yet how these two structures coordinate their activity during cognitive control remains poorly understood. We recorded from the human prefrontal cortex and the subthalamic nucleus simultaneously while participants (n = 22) performed a novel task involving high conflict trials, complete response inhibition trials, and trial-to-trial behavioural adaptations to conflict and errors...
October 25, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30358812/one-hundred-years-ago-nijinsky-and-the-origins-of-schizophrenia
#9
Emilio Fernandez-Egea
No abstract text is available yet for this article.
October 25, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30351346/atrophy-subtypes-in-prodromal-alzheimer-s-disease-are-associated-with-cognitive-decline
#10
Mara Ten Kate, Ellen Dicks, Pieter Jelle Visser, Wiesje M van der Flier, Charlotte E Teunissen, Frederik Barkhof, Philip Scheltens, Betty M Tijms
Alzheimer's disease is a heterogeneous disorder. Understanding the biological basis for this heterogeneity is key for developing personalized medicine. We identified atrophy subtypes in Alzheimer's disease dementia and tested whether these subtypes are already present in prodromal Alzheimer's disease and could explain interindividual differences in cognitive decline. First we retrospectively identified atrophy subtypes from structural MRI with a data-driven cluster analysis in three datasets of patients with Alzheimer's disease dementia: discovery data (dataset 1: n = 299, age = 67 ± 8, 50% female), and two independent external validation datasets (dataset 2: n = 181, age = 66 ± 7, 52% female; dataset 3: n = 227, age = 74 ± 8, 44% female)...
October 22, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30202947/stem-cell-therapies-in-neurology-the-good-the-bad-and-the-unknown
#11
Louisa Lyon
No abstract text is available yet for this article.
September 6, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30169600/improved-mobility-with-metformin-in-patients-with-myotonic-dystrophy-type-1-a-randomized-controlled-trial
#12
Guillaume Bassez, Etienne Audureau, Jean-Yves Hogrel, Raphaëlle Arrouasse, Sandrine Baghdoyan, Hamza Bhugaloo, Marie-Laurence Gourlay-Chu, Philippe Le Corvoisier, Marc Peschanski
Metformin, the well-known anti-diabetic drug, has been shown recently to improve the grip test performance of the DMSXL mouse model of myotonic dystrophy type 1. The drug may have positively affected muscle function via several molecular mechanisms, on RNA splicing, autophagia, insulin sensitivity or glycogen synthesis. Myotonic dystrophy remains essentially an unmet medical need. Since metformin benefits from a good toxicity profile, we investigated its potential for improving mobility in patients. Forty ambulatory adult patients were recruited consecutively at the neuromuscular reference centre of Henri-Mondor Hospital...
August 29, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30169601/basal-ganglia-and-cerebellar-pathology-in-x-linked-dystonia-parkinsonism
#13
Henrike Hanssen, Marcus Heldmann, Jannik Prasuhn, Volker Tronnier, Dirk Rasche, Cid C Diesta, Aloysius Domingo, Raymond L Rosales, Roland D Jamora, Christine Klein, Thomas F Münte, Norbert Brüggemann
X-linked dystonia-parkinsonism is a neurodegenerative movement disorder characterized by adult-onset dystonia combined with parkinsonism over the disease course. Previous imaging and pathological findings indicate exclusive striatal atrophy with predominant pathology of the striosomal compartment in the dystonic phase of X-linked dystonia-parkinsonism. The striosome occupies 10-15% of the entire striatal volume and the density of striosomes follows a rostrocaudal gradient with the rostral striatum being considered striosome-rich...
August 28, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30137217/induction-of-migraine-like-headache-but-not-aura-by-cilostazol-in-patients-with-migraine-with-aura
#14
Jawad H Butt, Egill Rostrup, Aina S Hansen, Kate L Lambertsen, Christina Kruuse
Whether migraine headache and migraine aura share common pathophysiological mechanisms remains to be understood. Cilostazol causes cAMP accumulation and provokes migraine-like headache in migraine patients without aura. We investigated if cilostazol induces aura and migraine-like headache in patients with migraine with aura and alters peripheral endothelial function and levels of endothelial markers. In a randomized, double-blinded, placebo-controlled crossover study, 16 patients with migraine with aura (of whom 12 patients exclusively had attacks of migraine with aura) received 200 mg cilostazol (Pletal®) or placebo on two separate days...
August 22, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30364983/multiple-sclerosis-is-it-all-black-and-white-in-optical-coherence-tomography
#15
Lilian Aly, Thomas Korn
No abstract text is available yet for this article.
November 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30364982/listening-for-the-rhythm-of-a-conscious-brain
#16
Rodika Sokoliuk, Damian Cruse
No abstract text is available yet for this article.
November 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30364981/phactring-in-actin-actin-deregulation-in-genetic-epilepsies
#17
Lara Eid, Praveen K Raju, Elsa Rossignol
No abstract text is available yet for this article.
November 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30364980/editorial
#18
Dimitri M Kullmann
No abstract text is available yet for this article.
November 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30364979/pre-and-postsynaptic-effects-of-lgi1-autoantibodies-in-a-murine-model-of-limbic-encephalitis
#19
Dominique Debanne, Oussama El Far
No abstract text is available yet for this article.
November 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30358817/brodmann-a-pioneer-of-human-brain-mapping-his-impact-on-concepts-of-cortical-organization
#20
Karl Zilles
No abstract text is available yet for this article.
November 1, 2018: Brain: a Journal of Neurology
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