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Brain: a Journal of Neurology

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https://www.readbyqxmd.com/read/28899027/editorial
#1
Dimitri M Kullmann
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899026/dead-salmon-and-voodoo-correlations-should-we-be-sceptical-about-functional-mri
#2
Louisa Lyon
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899025/the-nociferous-influence-of-interictal-discharges-on-memory
#3
Jonathan K Kleen, Heidi E Kirsch
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899024/a-restless-night-makes-for-a-rising-tide-of-amyloid
#4
Bryce A Mander, Joseph R Winer, Matthew P Walker
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899023/the-circadian-profile-of-epilepsy-improves-seizure-forecasting
#5
Philippa J Karoly, Hoameng Ung, David B Grayden, Levin Kuhlmann, Kent Leyde, Mark J Cook, Dean R Freestone
It is now established that epilepsy is characterized by periodic dynamics that increase seizure likelihood at certain times of day, and which are highly patient-specific. However, these dynamics are not typically incorporated into seizure prediction algorithms due to the difficulty of estimating patient-specific rhythms from relatively short-term or unreliable data sources. This work outlines a novel framework to develop and assess seizure forecasts, and demonstrates that the predictive power of forecasting models is improved by circadian information...
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899022/correlating-quantitative-susceptibility-mapping-with-cognitive-decline-in-alzheimer-s-disease
#6
Paul J Derry, Thomas A Kent
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899021/cortex-wide-optical-imaging-and-network-analysis-of-antidepressant-effects
#7
Ben S Huang, Conor Liston
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899020/progression-marker-of-parkinson-s-disease-a-4-year-multi-site-imaging-study
#8
Roxana G Burciu, Edward Ofori, Derek B Archer, Samuel S Wu, Ofer Pasternak, Nikolaus R McFarland, Michael S Okun, David E Vaillancourt
Progression markers of Parkinson's disease are crucial for successful therapeutic development. Recently, a diffusion magnetic resonance imaging analysis technique using a bitensor model was introduced allowing the estimation of the fractional volume of free water within a voxel, which is expected to increase in neurodegenerative disorders such as Parkinson's disease. Prior work demonstrated that free water in the posterior substantia nigra was elevated in Parkinson's disease compared to controls across single- and multi-site cohorts, and increased over 1 year in Parkinson's disease but not in controls at a single site...
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899019/cerebral-quantitative-susceptibility-mapping-predicts-amyloid-%C3%AE-related-cognitive-decline
#9
Scott Ayton, Amir Fazlollahi, Pierrick Bourgeat, Parnesh Raniga, Amanda Ng, Yen Ying Lim, Ibrahima Diouf, Shawna Farquharson, Jurgen Fripp, David Ames, James Doecke, Patricia Desmond, Roger Ordidge, Colin L Masters, Christopher C Rowe, Paul Maruff, Victor L Villemagne, Olivier Salvado, Ashley I Bush
See Derry and Kent (doi:10.1093/awx167) for a scientific commentary on this article.The large variance in cognitive deterioration in subjects who test positive for amyloid-β by positron emission tomography indicates that convergent pathologies, such as iron accumulation, might combine with amyloid-β to accelerate Alzheimer's disease progression. Here, we applied quantitative susceptibility mapping, a relatively new magnetic resonance imaging method sensitive to tissue iron, to assess the relationship between iron, amyloid-β load, and cognitive decline in 117 subjects who underwent baseline magnetic resonance imaging and amyloid-β positron emission tomography from the Australian Imaging, Biomarkers and Lifestyle study (AIBL)...
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899018/encephalitis-lethargica-100-years-after-the-epidemic
#10
Leslie A Hoffman, Joel A Vilensky
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899017/cortical-functional-hyperconnectivity-in-a-mouse-model-of-depression-and-selective-network-effects-of-ketamine
#11
Alexander McGirr, Jeffrey LeDue, Allen W Chan, Yicheng Xie, Timothy H Murphy
See Huang and Liston (doi:10.1093/awx166) for a scientific commentary on this article.Human depression is associated with glutamatergic dysfunction and alterations in resting state network activity. However, the indirect nature of human in vivo glutamate and activity assessments obscures mechanistic details. Using the chronic social defeat mouse model of depression, we determine how mesoscale glutamatergic networks are altered after chronic stress, and in response to the rapid acting antidepressant, ketamine...
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899016/reply-the-phenotypic-and-molecular-spectrum-of-peho-syndrome-and-peho-like-disorders
#12
Anna-Kaisa Anttonen, Anna-Elina Lehesjoki
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899015/the-phenotypic-and-molecular-spectrum-of-peho-syndrome-and-peho-like-disorders
#13
Vincenzo Salpietro, Massimo Zollo, Jana Vandrovcova, Mina Ryten, Juan A Botia, Veronica Ferrucci, Andreea Manole, Stephanie Efthymiou, Fuad Al Mutairi, Enrico Bertini, Marco Tartaglia
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899014/slow-wave-sleep-disruption-increases-cerebrospinal-fluid-amyloid-%C3%AE-levels
#14
Yo-El S Ju, Sharon J Ooms, Courtney Sutphen, Shannon L Macauley, Margaret A Zangrilli, Gina Jerome, Anne M Fagan, Emmanuel Mignot, John M Zempel, Jurgen A H R Claassen, David M Holtzman
See Mander et al. (doi:10.1093/awx174) for a scientific commentary on this article.Sleep deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote amyloid plaques and other downstream Alzheimer's disease pathologies including tauopathy or inflammation. To date, studies have not examined which aspect of sleep modulates amyloid-β or other Alzheimer's disease biomarkers. Seventeen healthy adults (age 35-65 years) without sleep disorders underwent 5-14 days of actigraphy, followed by slow wave activity disruption during polysomnogram, and cerebrospinal fluid collection the following morning for measurement of amyloid-β, tau, total protein, YKL-40, and hypocretin...
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899013/the-fatigue-conundrum
#15
Annapoorna Kuppuswamy
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899012/reply-neuronal-intranuclear-hyaline-inclusion-disease-and-fragile-x-associated-tremor-ataxia-syndrome-a-morphological-and-molecular-dilemma
#16
Jun Sone, Tomohiko Nakamura, Haruki Koike, Masahisa Katsuno, Fumiaki Tanaka, Yasushi Iwasaki, Mari Yoshida, Gen Sobue
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899011/neuronal-intranuclear-hyaline-inclusion-disease-and-fragile-x-associated-tremor-ataxia-syndrome-a-morphological-and-molecular-dilemma
#17
Ellen Gelpi, Teresa Botta-Orfila, Laia Bodi, Stefanie Marti, Gabor Kovacs, Oriol Grau-Rivera, Manuel Lozano, Raquel Sánchez-Valle, Esteban Muñoz, Francesc Valldeoriola, Javier Pagonabarraga, Gian-Gaetano Tartaglia, Montserrat Milà
No abstract text is available yet for this article.
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899010/modelling-apoe-%C3%A9-3-4-allele-associated-sporadic-alzheimer-s-disease-in-an-induced-neuron
#18
Hongwon Kim, Junsang Yoo, Jaein Shin, Yujung Chang, Junghyun Jung, Dong-Gyu Jo, Janghwan Kim, Wonhee Jang, Christopher J Lengner, Byung-Soo Kim, Jongpil Kim
The recent generation of induced neurons by direct lineage conversion holds promise for in vitro modelling of sporadic Alzheimer's disease. Here, we report the generation of induced neuron-based model of sporadic Alzheimer's disease in mice and humans, and used this system to explore the pathogenic mechanisms resulting from the sporadic Alzheimer's disease risk factor apolipoprotein E (APOE) ɛ3/4 allele. We show that mouse and human induced neurons overexpressing mutant amyloid precursor protein in the background of APOE ɛ3/4 allele exhibit altered amyloid precursor protein (APP) processing, abnormally increased production of amyloid-β42 and hyperphosphorylation of tau...
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899009/in-and-out-of-control-brain-mechanisms-linking-fluency-of-action-selection-to-self-agency-in-patients-with-schizophrenia
#19
Martin Voss, Valérian Chambon, Dorit Wenke, Simone Kühn, Patrick Haggard
Sense of agency refers to the feeling of control over one's actions, and their consequences. It involves both predictive processes linked to action control, and retrospective 'sense-making' causal inferences. Schizophrenia has been associated with impaired predictive processing, but the underlying mechanisms that impair patients' sense of agency remain unclear. We introduce a new 'prospective' aspect of agency and show that subliminally priming an action not only influences response times, but also influences reported sense of agency over subsequent action outcomes...
August 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28899008/phenotypic-analysis-of-303-multiplex-families-with-common-epilepsies
#20
MULTICENTER STUDY
(no author information available yet)
Gene identification in epilepsy has mainly been limited to large families segregating genes of major effect and de novo mutations in epileptic encephalopathies. Many families that present with common non-acquired focal epilepsies and genetic generalized epilepsies remain unexplained. We assembled a cohort of 'genetically enriched' common epilepsies by collecting and phenotyping families containing multiple individuals with unprovoked seizures. We aimed to determine if specific clinical epilepsy features aggregate within families, and whether this segregation of phenotypes may constitute distinct 'familial syndromes' that could inform genomic analyses...
August 1, 2017: Brain: a Journal of Neurology
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