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Antony P McNamee, Geoff D Tansley, Surendran Sabapathy, Michael J Simmonds
INTRODUCTION: Despite current generation mechanical assist devices being designed to limit shear stresses and minimise damage to formed elements in blood, severe secondary complications suggestive of impaired rheological functioning are still observed. At present, the precise interactions between the magnitude-duration of shear stress exposure and the deformability of red blood cells (RBC) remain largely undescribed for repeated subhaemolytic shear stress duty-cycles of less than 15 s...
September 20, 2016: Biorheology
Pinar Ulker
: Backround:Possible toxic effects of hyperoxia have been reported previously. However, the number of studies investigating the influence of hyperoxia on blood cells is limited and there are no data regarding its hemorheological effects. OBJECTIVE: The aim of this study was to investigate the effects of acute hyperoxia, performed in human subjects at normal atmospheric pressure, on the rheological properties of blood. METHOD: The study was conducted with 12 brain death patients mechanically ventilated in the intensive care unit...
August 10, 2016: Biorheology
Konstantinos M Lampropoulos, Dimitrios P Sokolis
BACKGROUND: Limited attention has been paid to the role of beta-adrenergic blocking agents on large artery function/structure, despite being clinically useful for treating many forms of cardiovascular disease. OBJECTIVE: To assess long-term consequences of beta-blocker administration on the biomechanical properties, geometry, and histological structure of two major elastic arteries. METHODS: Healthy male rats received water with their food, while beta-blockade was produced in rats by adding propranolol in their drinking water...
July 29, 2016: Biorheology
L Martin-Alarcon, T A Schmidt
The rheological properties of synovial fluid (SF) are largely attributed to the presence of high molecular weight hyaluronan (HA). However, rheological differences between SF and pure HA solutions suggest that SF proteins actively contribute towards the bulk viscoelasticity of this biological fluid. Due to various experimental challenges involved with the rheometry of low-viscosity biological fluids, the macromolecular interactions in SF and their relative rheological importance are still a matter of active discussion...
July 29, 2016: Biorheology
Jae-Suk Lee, Makoto Kaibara, Edgar A O'Rear
BACKGROUND: Devices gauging viscoelastic properties of blood during coagulation like the thromboelastograph support fundamental research as well as point of care needs. Associated fibrinolysis data are based on endogenous species or plasminogen activator added to a homogeneous sample prior to clot formation. Digestion in a monolithic structure differs from the physical situation of thrombolytic therapy where surface reactions dominate. OBJECTIVE: This study aims to develop rheological testing for heterogeneous phase fibrinolysis...
July 29, 2016: Biorheology
Mark B Plotnikov, Oleg I Aliev, Alexey V Nosarev, Alexander Y Shamanaev, Anastasia V Sidekhmenova, Yana Anfinogenova, Anna M Anishchenko, Ekaterina V Pushkina
BACKGROUND: Systemic arterial pressure (AP) depends on two physiological variables: cardiac output (CO) and total peripheral resistance (TPR). The latter depends on vascular hindrance and blood viscosity (BV). However, the relative contributions of the vascular and rheological factors to TPR remain unclear. OBJECTIVE: The aim of our work was to study the haemodynamic and haemorheologic effects of a treatment course with pentoxifylline (PTX) in SHRs in an effort to assess the impact of the rheological factor on TPR and AP...
July 26, 2016: Biorheology
Vasilios A Morikis, Chris Radecke, Yanyan Jiang, Volkmar Heinrich, Fitz-Roy Curry, Scott I Simon
No abstract text is available yet for this article.
July 4, 2016: Biorheology
Matthieu Robert de Saint Vincent
BACKGROUND: Biological cells exhibit complex mechanical properties which determine their responses to applied force. OBJECTIVE: We developed an optical method to probe the temporal evolution of power-law rheology of single cells. METHODS: The method consisted in applying optically a constant mechanical torque to a birefringent microparticle bound to the cell membrane, and observing dynamics of the particle's in-plane rotation. RESULTS: The deformation dynamics of the membrane followed a power law of time, which directly relates to cytoskeletal prestress as reported in the literature...
May 26, 2016: Biorheology
Dimitrios Kokkinos, Haider Dakhil, Andreas Wierschem, Heiko Briesen, André Braun
BACKGROUND: High-density cultures require operating below the critical threshold of shear stress, in order to avoid reducing the specific growth rate of the cells. When determining this threshold, direct inspection of the cells in flow provides insight into the conditions of shearing. OBJECTIVE: Aim of this study was using a novel rheo-optical setup for the observation of cells in laminar shear flow and the determination of the critical shear stress required to damage them in their natural environment...
March 10, 2016: Biorheology
Saranya Rajendran, Lakshmikirupa Sundaresan, Krithika Rajendran, Monica Selvaraj, Ravi Gupta, Suvro Chatterjee
BACKGROUND: Fluid flow plays an important role in vascular development. However, the detailed mechanisms, particularly the link between flow and modulation of gene expression during vascular development, remain unexplored. In chick embryo, the key events of vascular development from initiation of heart beat to establishment of effective blood flow occur between the stages HH10 and HH13. Therefore, we propose a novel in vivo model to study the flow experienced by developing endothelium...
February 11, 2016: Biorheology
Yali Wang, Feng Hu, Xiaoyan Mu, Feng Wu, Dechun Yang, Guixiang Zheng, Xiaoning Sun, Kaizheng Gong, Zhengang Zhang
OBJECTIVES: Drag-reducing polymers (DRPs) are blood-soluble macromolecules which may increase blood flow and reduce vascular resistance. The purpose of the present study was to observe the effect of DRPs on monocrotaline-induced pulmonary hypertension (PH) in the rat model. METHODS: A total of 64 male Wistar rats were randomly divided into four groups: Group I (pulmonary hypertension model + DRP treatment); Group II (pulmonary hypertension model + saline treatment); Group III (control + DRP treatment); Group IV (control + saline treatment)...
January 27, 2016: Biorheology
Mikhail Y Maslov, Tatiana M Plotnikova, Anna M Anishchenko, Oleg I Aliev, Nikolay E Nifantiev, Mark B Plotnikov
BACKGROUND: Postmenopausal women often develop hemorheological disorders which may affect the systemic blood circulation and present a cardiovascular risk factor. OBJECTIVE: We evaluated effects of secoisolariciresinol (SECO), a phytoestrogen, on hemorheological parameters and lipid peroxidation in a model of the age-related and/or surgical menopause induced by ovariectomy in rats. METHODS: Arterial blood was sampled from sham-operated female rats, ovariectomized rats (OVX), and OVX treated with SECO (OVXSECO) (20 mg/kg/day intragastrically for two weeks)...
January 7, 2016: Biorheology
Zhichao Fan, Klaus Ley
Integrins are a group of heterodimeric transmembrane receptors that play essential roles in cell-cell and cell-matrix interaction. Integrins are important in many physiological processes and diseases. Integrins acquire affinity to their ligand by undergoing molecular conformational changes called activation. Here we review the molecular biomechanics during conformational changes of integrins, integrin functions in leukocyte biorheology (adhesive functions during rolling and arrest) and molecules involved in integrin activation...
2015: Biorheology
Giles R Cokelet
No abstract text is available yet for this article.
2015: Biorheology
Shu Chien
No abstract text is available yet for this article.
2015: Biorheology
Herbert H Lipowsky, Gerard Nash
No abstract text is available yet for this article.
2015: Biorheology
Mathias Sander, Julia Flesch, Albrecht Ott
The cell monolayer rheology technique consists of a commercial rotational rheometer that probes the mechanical properties of a monolayer of isolated cells. So far we have described properties of an entire monolayer. In this short communication, we show that we can deduce average single cell properties. Results are in very good agreement with earlier work on single cell mechanics. Our approach provides a mean of 105-106 adherent cells within a single experiment. This makes the results very reproducible. We extend our work on cell adhesion strength and deduce cell adhesion forces of fibroblast cells on fibronectin coated glass substrates...
2015: Biorheology
William H McIntosh, Mesude Ozturk, Linden A Down, Dimitrios V Papavassiliou, Edgar A O'Rear
BACKGROUND: Energy losses at tube or blood vessel orifices depend on the extent of flare as measured by the dimensionless ratio of the fillet radius of curvature to diameter (r/D). OBJECTIVE: The goal of this study was to assess the effect of ostial fillet radii on energy losses at the aorta-renal artery junctions since as much as a quarter of cardiac output passes through the kidneys. METHOD: Pressure loss coefficients K for the renal artery ostia as a function of r/D have been determined for representative anatomical variants using finite volume simulations...
2015: Biorheology
Vasilios A Morikis, Chris Radecke, Yanyan Jiang, Volkmar Heinrich, Fitz-Roy Curry, Scott I Simon
BACKGROUND: Recombinant atrial natriuretic peptide (ANP) is administered in patients with acute heart failure in Japan to improve renal function and hemodynamics, but its anti-inflammatory effect on activated leukocytes may also contribute to its therapeutic efficacy. OBJECTIVE: Examine unconventional role of ANP in neutrophil adhesion to inflamed endothelium. METHODS: Human neutrophils were perfused over endothelial monolayers in a microfluidic lab-chip assay...
2015: Biorheology
Shu Zhu, Bradley A Herbig, Ruizhi Li, Thomas V Colace, Ryan W Muthard, Keith B Neeves, Scott L Diamond
Microfluidic devices create precisely controlled reactive blood flows and typically involve: (i) validated anticoagulation/pharmacology protocols, (ii) defined reactive surfaces, (iii) defined flow-transport regimes, and (iv) optical imaging. An 8-channel device can be run at constant flow rate or constant pressure drop for blood perfusion over a patterned collagen, collagen/kaolin, or collagen/tissue factor (TF) to measure platelet, thrombin, and fibrin dynamics during clot growth. A membrane-flow device delivers a constant flux of platelet agonists or coagulation enzymes into flowing blood...
2015: Biorheology
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