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Archives of Biochemistry and Biophysics

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https://www.readbyqxmd.com/read/28810138/corrigendum-to-a-comprehensive-review-on-the-colourless-carotenoids-phytoene-and-phytofluene-arch-biochem-biophys-572-2015-188-200
#1
Antonio J Meléndez-Martínez, Paula Mapelli-Brahm, Ana Benítez-González, Carla M Stinco
No abstract text is available yet for this article.
August 12, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28807613/identification-and-quantification-and-antioxidant-activity-of-flavonoids-in-different-strains-of-silk-cocoon-bombyx-mori
#2
Supamas Napavichayanun, Oliver Lutz, Martin Fischnaller, Thomas Jakschitz, Günther Bonn, Pornanong Aramwit
Silk cocoon is produced from silkworm (Bombyx mori) to protect itself from outer environment. Various strains of cocoon contain different forms and amounts of flavonoids, which may affect on their antioxidant activity. Moreover, the extraction method would influence the amount of flavonoids extracted. Therefore, the objectives of this study were to identify and quantify the flavonoids in 3 strains of bivoltine Bombyx mori silk cocoon (Chul 1/1; white cocoon, Chul 3/2; greenish cocoon, and Chul 4/2; yellow cocoon) extracted by 6 different solvents including acetone, ethyl acetate, dimethyl sulfoxide (DMSO), ethanol, methanol, and purified water...
August 11, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28803837/silencing-of-glut1-induces-chemoresistance-via-modulation-of-akt-gsk-3%C3%AE-%C3%AE-catenin-survivin-signaling-pathway-in-breast-cancer-cells
#3
Sunhwa Oh, KeeSoo Nam, Hyungjoo Kim, Incheol Shin
Cancer cells require increased aerobic glycolysis to support rapid cell proliferation. For their increased energy demands, cancer cells express glucose transporter (Glut) proteins at a high level. Glut1 is associated with basal-like breast cancer and is considered a potential therapeutic target. To investigate the possibility of Glut1 as a therapeutic target in breast cancer cells, we downregulated Glut1 in triple-negative breast cancer (TNBC) cell lines using a short hairpin system. We determined whether Glut1 silencing might enhance anti-proliferative effect of chemotherapeutic agents...
August 10, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28803836/methionine-sulfoxide-reductase-a-protects-against-lipopolysaccharide-induced-septic-shock-via-negative-regulation-of-the-proinflammatory-responses
#4
Mahendra Pratap Singh, Ki Young Kim, Geun-Hee Kwak, Suk-Hwan Baek, Hwa-Young Kim
Methionine sulfoxide reductase A (MsrA) is a major antioxidant enzyme that specifically catalyzes the reduction of methionine S-sulfoxide. In this study, we used MsrA gene-knockout (MsrA(-/-)) mice and bone marrow-derived macrophages (BMDMs) to investigate the role of MsrA in the regulation of inflammatory responses induced by lipopolysaccharide (LPS). MsrA(-/-) mice were more susceptible to LPS-induced lethal shock than wild-type (MsrA(+/+)) mice. Serum levels of the proinflammatory cytokines IL-6 and TNF-α induced by LPS were higher in MsrA(-/-) than in MsrA(+/+) mice...
August 10, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28802828/photolyase-dynamics-and-electron-transfer-mechanisms-of-dna-repair
#5
REVIEW
Meng Zhang, Lijuan Wang, Dongping Zhong
Photolyase, a flavoenzyme containing flavin adenine dinucleotide (FAD) molecule as a catalytic cofactor, repairs UV-induced DNA damage of cyclobutane pyrimidine dimer (CPD) and pyrimidine-pyrimidone (6-4) photoproduct using blue light. The FAD cofactor, conserved in the whole protein superfamily of photolyase/cryptochromes, adopts a unique folded configuration at the active site that plays a critical functional role in DNA repair. Here, we review our comprehensive characterization of the dynamics of flavin cofactor and its repair photocycles by different classes of photolyases on the most fundamental level...
August 9, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28802827/the-novel-heme-dependent-inducible-protein-srrd-regulates-heme-biosynthesis-and-circadian-rhythms
#6
Yuka Adachi, Mana Umeda, Asako Kawazoe, Tetsuya Sato, Yasuyuki Ohkawa, Sakihito Kitajima, Shingo Izawa, Ikuko Sagami, Shigeru Taketani
Heme plays a role in the regulation of the expression of genes related to circadian rhythms and heme metabolism. In order to identify new heme-regulated proteins, an RNA sequence analysis using mouse NIH3T3 cells treated without or with 5-aminolevulinic acid (ALA) was performed. Among the changes observed in the levels of various mRNAs including heme oxygenase-1 (HO-1) and ALA synthase-1 (ALAS1), a mouse homologue of the plant circadian-regulating protein SRR1, SRR1 domain containing (SRRD) was induced by the ALA treatment...
August 9, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28801166/nuclear-factor-erythroid-derived-2-like-2-nrf2-drug-discovery-biochemical-toolbox-to-develop-nrf2-activators-by-reversible-binding-of-kelch-like-ech-associated-protein-1-keap1
#7
REVIEW
Alberto Bresciani, Antonino Missineo, Mariana Gallo, Mauro Cerretani, Paola Fezzardi, Licia Tomei, Daniel Oscar Cicero, Sergio Altamura, Alessia Santoprete, Raffaele Ingenito, Elisabetta Bianchi, Robert Pacifici, Celia Dominguez, Ignacio Munoz-Sanjuan, Steven Harper, Leticia Toledo-Sherman, Larry C Park
Mechanisms that activate innate antioxidant responses, as a way to mitigate oxidative stress at the site of action, hold much therapeutic potential in diseases, such as Parkinson's disease, Alzheimer's disease and Huntington's disease, where the use of antioxidants as monotherapy has not yielded positive results. The nuclear factor NRF2 is a transcription factor whose activity upregulates the expression of cell detoxifying enzymes in response to oxidative stress. NRF2 levels are modulated by KEAP1, a sensor of oxidative stress...
August 8, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28797635/circadian-rhythmicity-a-functional-connection-between-differentiated-embryonic-chondrocyte-1-dec1-and-small-heterodimer-partner-shp
#8
Marek M Marczak, Bingfang Yan
Circadian rhythm misalignment has been increasingly recognized to pose health risk for a wide range of diseases, particularly metabolic disorders. The liver maintains metabolic homeostasis and expresses many circadian genes, such as differentiated embryo chondrocyte-1 (DEC1) and small heterodimer partner (SHP). DEC1 is established to repress transcription through E-box elements, and SHP belongs to the superfamily of nuclear receptors and has multiple E-box elements in its promoter. Importantly, DEC1 and SHP are inversely oscillated...
August 8, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28789935/tetramer-as-efficient-structural-mode-for-organizing-antioxidative-carboxylic-acids-the-case-in-inhibiting-dna-oxidation
#9
Ri Zhou, Zai-Qun Liu
To overcome the problem on the relationship of antioxidative effect with the branch number in a tetramer, we herein designed a series of antioxidants with pentaerythritol, glycerol, and ethylene glycol as the cores, and gallic, ferulic, caffeic, and p-hydroxybenzoic acids as the antioxidative moieties. In the case of DNA oxidation mediated by 2,2'-azobis(2-amidinopropane hydrochloride, AAPH), it was found that the stoichiometric factor (n) of a carboxylic acid increased rapidly when the acid was esterified with ethylene glycol, glycerol, and pentaerythritol to form a dimer, trimer, and tetramer, respectively...
August 5, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28784589/flavin-n5-oxide-a-new-catalytic-motif-in-flavoenzymology
#10
REVIEW
Sanjoy Adak, Tadhg P Begley
No abstract text is available yet for this article.
August 5, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28784588/probing-the-interaction-of-the-p53-c-terminal-domain-to-the-histone-demethylase-lsd1
#11
Valentina Speranzini, Giuseppe Ciossani, Chiara Marabelli, Andrea Mattevi
The p53 transcription factor plays a central role in the regulation of the expression of several genes, and itself is post-translationally regulated through its different domains. Of particular relevance for p53 function is its intrinsically disordered C-terminal domain (CTD), representing a hotspot for post-translational modifications and a docking site for transcriptional regulators. For example, the histone H3 lysine demethylase 1 (LSD1) interacts with p53 via the p53-CTD for mutual regulation. To biochemically and functionally characterize this complex, we evaluated the in vitro interactions of LSD1 with several p53-CTD peptides differing in length and modifications...
August 4, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28778458/automatic-regulation-of-nf-%C3%AE%C2%BAb-by-phsp70-i%C3%AE%C2%BAb%C3%AE-m-to-prevent-acute-lung-injury-in-mice
#12
Hai-Ying Dong, Yan Cui, Bo Zhang, Ying Luo, Yan-Xia Wang, Ming-Qing Dong, Man-Ling Liu, Peng-Tao Zhao, Wen Niu, Zhi-Chao Li
Controlling target gene expression is a vital step in the procedure of gene therapy upon acute lung injury (ALI). Excessive activation of nuclear factor-kappa B (NF-κB) has been the key point of the inflammation overwhelming process in onset of ALI. We designed and tested a variety of plasmid named pHSP70/IκBαm which conditionally carries a mutant inhibitor of kappa B (IκB) transgene to regulate the activity of NF-κB signaling pathway in its response to an inflammatory stimulus that causes acute lung injury...
August 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28774660/the-distribution-and-mechanism-of-iodotyrosine-deiodinase-defied-expectations
#13
REVIEW
Zuodong Sun, Qi Su, Steven E Rokita
Iodotyrosine deiodinase (IYD) is unusual for its reliance on flavin and ability to promote reductive dehalogenation under aerobic conditions. As implied by the name, this enzyme was first discovered to catalyze iodide elimination from iodotyrosine for recycling iodide during synthesis of tetra- and triiodothyronine collectively known as thyroid hormone. However, IYD likely supports many more functions and has been shown to debrominate and dechlorinate bromo- and chlorotyrosines. A specificity for halotyrosines versus halophenols is well preserved from humans to bacteria...
July 31, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28764891/2-methoxyethylacrylate-modified-polysulfone-membrane-and-its-blood-compatibility
#14
Xin Tian, Yun-Ren Qiu
Hydrophilic material of 2-methoxyethylacrylate (MEA) was grafted from polysulfone (PSF) membrane via Michael addition reaction. The (1)H-nuclear magnetic resonance ((1)H NMR) and X-ray photoelectron spectroscopy (XPS) characterizations of the modified membrane showed that MEA had been successfully grafted onto PSF membrane surface. The water contact angle of the membrane surface was tested. The results showed that the water contact angle changed from 76° to 59.5°, it means that the hydrophilicity of the modified membrane was improved...
July 29, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28760597/human-and-plasmodium-serine-hydroxymethyltransferases-differ-in-rate-limiting-steps-and-ph-dependent-substrate-inhibition-behavior
#15
Watcharee Amornwatcharapong, Somchart Maenpuen, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen
Serine hydroxymethyltransferase (SHMT), an essential enzyme for cell growth and development, catalyzes the transfer of -CH2OH from l-serine to tetrahydrofolate (THF) to form glycine and 5,10-methylenetetrahydrofolate (MTHF) which is used for nucleotide synthesis. Insights into the ligand binding and inhibition properties of human cytosolic SHMT (hcSHMT) and Plasmodium SHMT (PvSHMT) are crucial for designing specific drugs against malaria and cancer. The results presented here revealed strong and pH-dependent THF inhibition of hcSHMT...
July 29, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28755973/l-cysteine-supplementation-increases-insulin-sensitivity-mediated-by-upregulation-of-gsh-and-adiponectin-in-high-glucose-treated-3t3-l1-adipocytes
#16
Arunkumar E Achari, Sushil K Jain
Diabetic patients have lower blood levels of l-cysteine (LC) and glutathione (GSH). This study examined the hypothesis that LC supplementation positively up regulates the effects of insulin on GSH and glucose metabolism in 3T3-L1 adipocyte model. 3T3L1 adipocytes were treated with LC (250 μM, 2 h) and/or insulin (15 or 30 nM, 2 h), and high glucose (HG, 25 mM, 20 h). Results showed that HG caused significant increase (95%) in ROS and reduction in the protein levels of DsbA-L (43%), adiponectin (64%), GCLC (20%), GCLM (21%), GSH (50%), and GLUT-4 (23%) in adipocytes...
July 27, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28754323/the-ubix-ubid-system-the-biosynthesis-and-use-of-prenylated-flavin-prfmn
#17
REVIEW
Stephen A Marshall, Karl A P Payne, David Leys
The UbiX-UbiD system consists of the flavin prenyltransferase UbiX that produces prenylated FMN that serves as the cofactor for the (de)carboxylase UbiD. Recent developments have provided structural insights into the mechanism of both enzymes, detailing unusual chemistry in each case. The proposed reversible 1,3-dipolar cycloaddition between the cofactor and substrate serves as a model to explain many of the key UbiD family features. However, considerable variation exists in the many branches of the UbiD family tree...
July 25, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28754322/characterization-of-secondary-structure-and-lipid-binding-behavior-of-n-terminal-saposin-like-subdomain-of-human-wnt3a
#18
Aparna Krishnamoorthy, Andrzej Witkowski, Jesse J Tran, Paul M M Weers, Robert O Ryan
Wnt signaling is essential for embryonic development and adult homeostasis in multicellular organisms. A conserved feature among Wnt family proteins is the presence of two structural domains. Within the N-terminal (NT) domain there exists a motif that is superimposable upon saposin-like protein (SAPLIP) family members. SAPLIPs are found in plants, microbes and animals and possess lipid surface seeking activity. To investigate the function of the Wnt3a saposin-like subdomain (SLD), recombinant SLD was studied in isolation...
July 25, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28754321/crystal-structure-of-pisum-arvense-seed-lectin-pal-and-characterization-of-its-interaction-with-carbohydrates-by-molecular%C3%A2-docking-and-dynamics
#19
Vanir Reis Pinto-Junior, Mayara Queiroz Santiago, Camila Bezerra Nobre, Vinicius Jose Silva Osterne, Rodrigo Bainy Leal, Joao Batista Cajazeiras, Claudia Figueiredo Lossio, Bruno Anderson Matias Rocha, Maria Gleiciane Queiroz Martins, Clareane Avelino Simplicio Nobre, Mayara Torquato Lima Silva, Kyria Santiago Nascimento, Benildo Sousa Cavada
The Pisum arvense lectin (PAL), a legume protein belonging to the Vicieae tribe, is capable of specific recognition of mannose, glucose and its derivatives without altering its structure. In this work, the three-dimensional structure of PAL was determined by X-ray crystallography and studied in detail by a combination of molecular docking and molecular dynamics (MD). Crystals belonging to monoclinic space group P21 were grown by the vapor diffusion method at 293 K. The structure was solved at 2.16 Å and was similar to that of other Vicieae lectins...
July 25, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28750820/low-temperature-plasma-induces-angiogenic-growth-factor-via-up-regulating-hypoxia-inducible-factor-1%C3%AE-in-human-dermal-fibroblasts
#20
Hui Song Cui, So Young Joo, Dae Hoon Lee, Joo Hyang Yu, Je Hoon Jeong, June-Bum Kim, Cheong Hoon Seo
Numerous studies on the application of low temperature plasma (LTP) have produced impressive results, including antimicrobial, antitumor, and wound healing effects. Although LTP research has branched out to include medical applications, the detailed effects and working mechanisms of LTP on wound healing have not been fully investigated. Here, we investigated the potential effect of inducing growth factor after exposure to LTP and demonstrated the increased expression of angiogenic growth factor mediated by LTP-induced HIF1α expression in primary cultured human dermal fibroblasts...
July 24, 2017: Archives of Biochemistry and Biophysics
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