journal
MENU ▼
Read by QxMD icon Read
search

Experimental Neurology

journal
https://www.readbyqxmd.com/read/29317193/an-essential-role-for-neuregulin-4-in-the-growth-and-elaboration-of-developing-neocortical-pyramidal-dendrites
#1
Blanca Paramo, Sean Wyatt, Alun M Davies
Neuregulins, with the exception of neuregulin-4 (NRG4), have been shown to be extensively involved in many aspects of neural development and function and are implicated in several neurological disorders, including schizophrenia, depression and bipolar disorder. Here we provide the first evidence that NRG4 has a crucial function in the developing brain. We show that both the apical and basal dendrites of neocortical pyramidal neurons are markedly stunted in Nrg4-/- neonates in vivo compared with Nrg4+/+ littermates...
January 6, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29309751/activation-of-npy-y2-receptors-ameliorates-disease-pathology-in-the-r6-2-mouse-and-pc12-cell-models-of-huntington-s-disease
#2
Oluwaseun Fatoba, Eugen Kloster, Christiane Reick, Carsten Saft, Ralf Gold, Jörg T Epplen, Larissa Arning, Gisa Ellrichmann
Huntington's disease (HD) is a monogenic inherited polyglutamine-mediated neurodegenerative disorder for which effective therapies are currently unavailable. Neuropeptide Y (NPY) has been implicated as a potential therapeutic target in several neurodegenerative diseases, including HD. However, its mechanisms of action in the context of HD pathology remain unknown. Here, we investigated the beneficial effects of Y2 receptor (Y2R) activation with NPY or Y2R selective agonist NPY13-36 in the R6/2 mouse and PC12 cell models of HD...
January 5, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29307609/decreased-glutathione-levels-cause-overt-motor-neuron-degeneration-in-hsod1wt-over-expressing-mice
#3
Kelby M Killoy, Benjamin A Harlan, Mariana Pehar, Kristi L Helke, Jeffrey A Johnson, Marcelo R Vargas
Mutations in Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive loss of motor neurons. Several lines of evidence have shown that SOD1 mutations cause ALS through a gain of a toxic function that remains to be fully characterized. A significant share of our understanding of the mechanisms underlying the neurodegenerative process in ALS comes from the study of rodents over-expressing ALS-linked mutant hSOD1. These mutant hSOD1 models develop an ALS-like phenotype...
January 4, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29306704/neuroprotective-effect-of-acute-ethanol-intoxication-in-tbi-is-associated-to-the-hierarchical-modulation-of-early-transcriptional-responses
#4
Akila Chandrasekar, Bahar Aksan, Florian Olde Heuvel, Philip Förstner, Daniela Sinske, Rida Rehman, Annette Palmer, Albert Ludolph, Markus Huber-Lang, Tobias Böckers, Daniela Mauceri, Bernd Knöll, Francesco Roselli
Ethanol intoxication is a risk factor for traumatic brain injury (TBI) but clinical evidence suggests that it may actually improve the prognosis of intoxicated TBI patients. We have employed a closed, weight-drop TBI model of different severity (2cm or 3cm falling height), preceded (-30min) or followed (+20min) by ethanol administration (5g/Kg). This protocol allows us to study the interaction of binge ethanol intoxication in TBI, monitoring behavioral changes, histological responses and the transcriptional regulation of a series of activity-regulated genes (immediate early genes, IEGs)...
January 4, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29305892/the-involvement-of-the-pathway-connecting-the-substantia-nigra-the-periaqueductal-gray-matter-and-the-retrotrapezoid-nucleus-in-breathing-control-in-a-rat-model-of-parkinson-s-disease
#5
Juliana C Lima, Luiz M Oliveira, Marina T Botelho, Thiago S Moreira, Ana C Takakura
Parkinson's disease (PD) is characterized by a reduction in the number of dopaminergic neurons of the substantia nigra (SNpc), accompanied by motor and non-motor deficiencies such as respiratory failure. Here, our aim was to investigate possible neuronal communications between the SNpc and chemoreceptor neurons within the retrotrapezoid nucleus (RTN), in order to explain neurodegeneration and the loss of breathing function in the 6-OHDA PD animal model. Male Wistar rats received tracer injections in the SNpc, RTN and periaqueductal gray (PAG) regions to investigate the projections between those regions...
January 4, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29305051/interneuron-synaptopathy-in-developing-rat-cortex-induced-by-the-pro-inflammatory-cytokine-lif
#6
Maren Engelhardt, Mohammad I K Hamad, Alexander Jack, Küpra Ahmed, Jennifer König, Lisa Marie Rennau, Nora Jamann, Andrea Räk, Sabine Schönfelder, Christian Riedel, Markus Joseph Wirth, Silke Patz, Petra Wahle
No abstract text is available yet for this article.
January 2, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29305050/intraspinal-microstimulation-for-respiratory-muscle-activation
#7
Michael D Sunshine, Comron N Ganji, Paul J Reier, David D Fuller, Chet T Moritz
A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activates diaphragm (DIA) and external intercostal (EIC) motor units. Respiratory muscle electromyography (EMG) was recorded in anesthetized female spinally intact adult rats while a stimulating electrode was advanced ventrally into the spinal cord in 600μm increments...
January 2, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29291404/ulinastatin-protects-brain-against-cerebral-ischemia-reperfusion-injury-through-inhibiting-mmp-9-and-alleviating-loss-of-zo-1-and-occludin-proteins-in-mice
#8
Xiao-Fang Li, Xiang-Jian Zhang, Cong Zhang, Li-Na Wang, Yao-Ru Li, Ye Zhang, Ting-Ting He, Xing-Yuan Zhu, Li-Li Cui, Bu-Lang Gao
BACKGROUND: The effects of Ulinastatin (UTI) on the blood-brain barrier (BBB) in the acute phase of cerebral ischemia/reperfusion (I/R) are not clear. This study was to investigate the potential protective effects of UTI on the BBB and the underlying mechanisms. METHODS: Male CD-1 mice were subjected to transient middle cerebral artery occlusion (tMCAO) and randomly assigned to four groups: Sham (sham-operated), tMCAO (tMCAO+0.9% saline), UTI-L (tMCAO+UTI 1500U/100g) and UTI-H (tMCAO+UTI 3000U/100g) group...
December 29, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29291403/electrical-stimulation-as-a-conditioning-strategy-for-promoting-and-accelerating-peripheral-nerve-regeneration
#9
J L B Senger, V M K Verge, H S J Macandili, J L Olson, K M Chan, C A Webber
The delivery of a nerve insult (a "conditioning lesion") prior to a subsequent test lesion increases the number of regenerating axons and accelerates the speed of regeneration from the test site. A major barrier to clinical translation is the lack of an ethically acceptable and clinically feasible method of conditioning that does not further damage the nerve. Conditioning electrical stimulation (CES), a non-injurious intervention, has previously been shown to improve neurite outgrowth in vitro. In this study, we examined whether CES upregulates regeneration-associated gene (RAG) expression and promotes nerve regeneration in vivo, similar to a traditional nerve crush conditioning lesion (CCL)...
December 29, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29291402/chop-induces-apoptosis-by-affecting-brain-iron-metabolism-in-rats-with-subarachnoid-hemorrhage
#10
Jun Zhao, Xiang Xiang, Hongxia Zhang, Dengzhi Jiang, Yidan Liang, Wang Qing, Liu Liu, Qing Zhao, Zhaohui He
The endoplasmic reticulum stress-related factor CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) aggravates early brain injury (EBI) in rats after subarachnoid hemorrhage (SAH). Our research aims to investigate the role of CHOP-mediated iron metabolism in EBI after SAH and the underlying mechanism. Male Sprague-Dawley rats were used to establish SAH models. Tunicamycin (Tm) was employed to excite CHOP expression, and two CHOP small interfering RNAs (siRNAs) were used to inhibit CHOP expression...
December 29, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29288635/foxd3-inhibits-scn2a-gene-transcription-in-intractable-epilepsy-cell-models
#11
Jun Xiang, Fang Wen, Lingyun Zhang, Yu Zhou
The expression of sodium voltage-gated channel alpha subunit 2 (SCN2A) is closely related to the development of epilepsy. This study investigated regulatory element of the SCN2A gene involved in epilepsy. An intractable epilepsy cell model was constructed using hippocampal primary neurons and the SH-SY5Y cell line. SCN2A protein and gene expression in cells as well as the level of lactic acid dehydrogenase (LDH) in the cell culture supernatants was detected. Potential regulatory factors of SCN2A and its upstream regulatory elements were identified using the dual-luciferase reporter assay...
December 27, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29288070/neonatal-erythropoietin-mitigates-impaired-gait-social-interaction-and-diffusion-tensor-imaging-abnormalities-in-a-rat-model-of-prenatal-brain-injury
#12
Shenandoah Robinson, Christopher J Corbett, Jesse L Winer, Lindsay A S Chan, Jessie R Maxwell, Christopher V Anstine, Tracylyn R Yellowhair, Nicholas A Andrews, Yirong Yang, Laurel O Sillerud, Lauren L Jantzie
Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these children. Moreover, the mechanisms of perinatal brain injury that result in functional deficits and imaging abnormalities in the mature brain are poorly defined, limiting the potential to target interventions to those who may benefit most...
December 26, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29277625/enhanced-axonal-transport-a-novel-form-of-plasticity-after-primate-and-rodent-spinal-cord-injury
#13
J H Brock, E S Rosenzweig, H Yang, M H Tuszynski
Deficient axonal transport after injury is believed to contribute to the failure of CNS regeneration. To better elucidate neural mechanisms associated with CNS responses to injury, we transected the dominant voluntary motor system, the corticospinal tract (CST), in the dorsolateral T10 spinal cord of rhesus monkeys. Three months later, a 4.5-fold increase in the number of CST axons located in the spared ventral corticospinal tract at both the lesion site and, surprisingly, remotely in the cervical spinal cord was observed...
December 22, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29274721/cpg-odn-exerts-a-neuroprotective-effect-via-the-tlr9-pampk-signaling-pathway-by-activation-of-autophagy-in-a-neonatal-hie-rat-model
#14
Lan Ye, Zhanhui Feng, Desislava Doycheva, Jay Malaguit, Brandon Dixon, Ningbo Xu, John H Zhang, Jiping Tang
Hypoxic Ischemic Encephalopathy (HIE) is an injury caused to the brain due to prolonged lack of oxygen and blood supply which results in death or long-term disabilities. The main aim of this study was to investigate the role of Cytosine-phospho-guanine oligodeoxynucleotide (CpG-ODN) in autophagy after HIE. Ten-day old (P10) rat pups underwent right common carotid artery ligation followed by 2.5h of hypoxia as previously described by Rice-Vannucci. At 1h post HIE, rats were intranasally administered with recombinant CpG-ODN...
December 21, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29269117/age-at-injury-and-genotype-modify-acute-inflammatory-and-neurofilament-light-responses-to-mild-chimera-traumatic-brain-injury-in-wild-type-and-app-ps1-mice
#15
Wai Hang Cheng, Sophie Stukas, Kris M Martens, Dhananjay R Namjoshi, Emily B Button, Anna Wilkinson, Asma Bashir, Jerome Robert, Peter A Cripton, Cheryl L Wellington
Peak incidence of traumatic brain injury (TBI) occurs in both young and old individuals, and older age at injury is associated with worse outcome and poorer recovery. Moderate-severe TBI is a reported risk factor for dementia, including Alzheimer's disease (AD), but whether mild TBI (mTBI) alters AD pathogenesis is not clear. To delineate how age at injury and predisposition to amyloid formation affect the acute response to mTBI, we used the Closed Head Impact Model of Engineered Rotational Acceleration (CHIMERA) model of TBI to induce two mild injuries in wild-type (WT) and APP/PS1 mice at either 6 or 13months of age and assessed behavioural, histological and biochemical changes up to 14day post-injury...
December 18, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29262292/mice-overexpressing-lamin-b1-in-oligodendrocytes-recapitulate-the-age-dependent-motor-signs-but-not-the-early-autonomic-cardiovascular-dysfunction-of-autosomal-dominant-leukodystrophy-adld
#16
Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Cristiano Bombardi, Giovanna Calandra-Buonaura, Sabina Capellari, Gary Cohen, Pietro Cortelli, Laura Gasparini, Quasar Padiath, Alice Valli, Giovanna Zoccoli, Alessandro Silvani
Autosomal dominant leukodystrophy (ADLD) is a rare adult-onset demyelinating disease caused by overexpression of lamin B1, a nuclear lamina filament. Early autonomic dysfunction involving the cardiovascular system before progressive somatic motor dysfunction is a striking feature of most cases of ADLD. In the Plp-FLAG-LMNB1 transgenic mouse model, lamin B1 overexpression in oligodendrocytes elicits somatic motor dysfunction and neuropathology akin to ADLD. Here, we investigate whether Plp-FLAG-LMNB1 mice also develop autonomic cardiovascular dysfunctions before or after somatic motor dysfunction...
December 17, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29258835/the-glun1-glun2b-nmda-receptor-and-metabotropic-glutamate-receptor-1-negative-allosteric-modulator-has-enhanced-neuroprotection-in-a-rat-subarachnoid-hemorrhage-model
#17
Zongyong Zhang, Junke Liu, Cundong Fan, Leilei Mao, Rongxia Xie, Suyun Wang, Mingfeng Yang, Hui Yuan, Xiaoyi Yang, Jingyi Sun, Jian Wang, Jiming Kong, Siluo Huang, Baoliang Sun
Excessive glutamate in cerebrospinal fluid after subarachnoid hemorrhage (SAH) causes excitotoxic damage through calcium overloading and a subsequent apoptotic cascade. GluN1/GluN2B containing N-methyl-Daspartate (NMDA) receptor and metabotropic glutamate receptor 1 (mGluR1) can play a leading role in glutamate-mediated excitotoxicity. Here we report that Ifenprodil (100μM), a negative allosteric modulator (NAM) of GluN1/GluN2B NMDA receptors, and JNJ16259685 (10μM), a NAM of mGluR1, have an additive efficacy against glutamate (100μM)-induced Ca2+ release and cell apoptosis in primary cortical, hippocampal, and cerebellar granule neurons...
December 16, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29253508/roles-of-cdc42-and-rac-in-bergmann-glia-during-cerebellar-corticogenesis
#18
Isao Sakamoto, Takehiko Ueyama, Masakazu Hayashibe, Takashi Nakamura, Hiroaki Mohri, Hiroshi Kiyonari, Michiko Shigyo, Chihiro Tohda, Naoaki Saito
Bergmann glia (BG) are important in the inward type of radial migration of cerebellar granule neurons (CGNs). However, details regarding the functions of Cdc42 and Rac in BG for radial migration of CGN are unknown. To examine the roles of Cdc42 and Rac in BG during cerebellar corticogenesis, mice with a single deletion of Cdc42 or Rac1 and those with double deletions of Cdc42 and Rac1 under control of the glial fibrillary acidic protein (GFAP) promoter: GFAP-Cre;Cdc42flox/flox (Cdc42-KO), GFAP-Cre;Rac1flox/flox (Rac1-KO), and GFAP-Cre;Cdc42flox/flox;Rac1flox/flox (Cdc42/Rac1-DKO) mice, were generated...
December 15, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29248630/cortical-slow-wave-activity-correlates-with-striatal-synaptic-strength-in-normal-but-not-in-parkinsonian-rats
#19
Salvatore Galati, Song Wei, Gergely Orban, Andreas R Luft, Alain Kaelin-Lang
Urethane-induced cortical slow wave activity (SWA) spreads into the basal ganglia in dopamine (DA)-depleted rat models of Parkinson's disease (PD). During physiological sleep, SWA is powerfully expressed at the beginning of night and progressively reduced during sleep-time reflecting the sleep need. However, its underlying slow oscillations may contribute directly to modulate cortical plasticity. In order to determine the impact of the SWA on synaptic strength and its interplay with DA, we simultaneously recorded the electrocorticogram (ECoG) and the corticocortical- and corticostriatal-evoked potentials (CC-EPs, CS-EPs) during eight hours of robust urethane-induced SWA in both normal and PD animals...
December 15, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29229294/impact-of-dha-intake-in-a-mouse-model-of-synucleinopathy
#20
Katherine Coulombe, Olivier Kerdiles, Cyntia Tremblay, Vincent Emond, Manon Lebel, Anne-Sophie Boulianne, Mélanie Plourde, Francesca Cicchetti, Frédéric Calon
Polyunsaturated fatty acids omega-3 (n-3 PUFA), such as docosahexaenoic acid (DHA), have been shown to prevent, and partially reverse, neurotoxin-induced nigrostriatal denervation in animal models of Parkinson's disease (PD). However, the accumulation of α-synuclein (αSyn) in cerebral tissues is equally important to the pathophysiology. To determine whether DHA intake improves various aspects related to synucleinopathy, ninety male mice overexpressing human αSyn under the Thy-1 promoter (Thy1-αSyn) were fed one of three diets (specially formulated control, low n-3 PUFA or high DHA) and compared to non-transgenic C57/BL6 littermate mice exposed to a control diet...
December 8, 2017: Experimental Neurology
journal
journal
23388
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"