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Experimental and Molecular Pathology

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https://www.readbyqxmd.com/read/28545938/an-update-of-77-cases-diagnosed-as-oral-hemangiomas-based-on-glut-1-positivity
#1
Tiago João da Silva Filho, Denise Hélen Imaculada Pereira de Oliveira, Veruska Lima Moura Brasil, Cassiano Francisco Weege Nonaka, Éricka Janine Dantas da Silveira, Lélia Maria Guedes Queiroz
OBJECTIVES: To evaluate cases diagnosed as "oral hemangiomas" based on the immunohistochemical expression of human glucose transporter protein (GLUT-1) and on histopathological features, and to investigate whether the classification proposed by the ISSVA was used correctly to classify these lesions. MATERIAL AND METHODS: All cases stored in the archives of an Oral Pathology Service and diagnosed as "oral hemangiomas" were reviewed. Seventy-seven cases were analyzed regarding the expression of GLUT-1...
May 22, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28533125/markers-of-immune-mediated-inflammation-in-the-brains-of-young-adults-and-adolescents-with-type-1-diabetes-and-fatal-diabetic-ketoacidosis-is-there-a-difference
#2
William H Hoffman, Carol M Artlett, Dallas Boodhoo, Mary G F Gilliland, Luis Ortiz, Dries Mulder, David H T Tjan, Alvaro Martin, Alexandru Tatomir, Horea Rus
Due to the limited data on diabetic ketoacidosis and brain edema (DKA/BE) in children/adolescents and the lack of recent data on adults with type 1 diabetes (T1D), we addressed the question of whether neuroinflammation was present in the fatal DKA of adults. We performed immunohistochemistry (IHC) studies on the brains of two young adults with T1D and fatal DKA and compared them with two teenagers with poorly controlled diabetes and fatal DKA. C5b-9, the membrane attack complex (MAC) had significantly greater deposits in the grey and white matter of the teenagers than the young adults (p=0...
May 19, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28512015/the-association-between-mir-34-dysregulation-and-distant-metastases-formation-in-lung-adenocarcinoma
#3
Iben Daugaard, Alice Knudsen, Tina E Kjeldsen, Henrik Hager, Lise Lotte Hansen
Lung cancer has the highest mortality rate amongst human cancers and the majority of deaths can be attributed to metastatic spread. The miR-34 family includes three tumor suppressive miRs: miR-34a, miR-34b and miR-34c. miR-34 downregulation is a frequent observation in human malignancies and is often attributed to hypermethylation of the miR-34a and miR-34b/c promoters. Here, the potential association between aberrant miR-34 expression and promoter methylation and distant metastases formation in lung adenocarcinoma (LAC) is investigated...
May 13, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28506771/15d-pgj2-as-an-endoplasmic-reticulum-stress-manipulator-in-multiple-myeloma-in-vitro-and-in-vivo
#4
Marcelo Sperandio, Ana Paula D Demasi, Elizabeth F Martinez, Sara O Saad, Fernando V Pericole, Karla P Vieira, Nadir S Freitas, Vera C Araújo, Amy Louise Brown, Juliana Trindade Clemente-Napimoga, Marcelo Henrique Napimoga
Multiple myeloma (MM) is characterised by intense protein folding and, consequently endoplasmic reticulum (ER) stress. The prostaglandin 15d-PGJ2 is able to raise oxidative stress levels within the cell and potentially trigger cell death. The aim of this study was to evaluate the antineoplastic effect of 15d-PGJ2 on MM in vitro and in vivo via ER and oxidative stress pathways. MM.1R and MM.1S cell lines were treated with 15d-PGJ2 at 1-10μM and evaluated with regard to proliferation, mRNA expression of PRDX1, PRDX4, GRP78, GRP94, CHOP, BCL-2 and BAX...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28506770/prognostic-role-of-telomere-length-in-malignancies-a-meta-analysis-and-meta-regression
#5
Roman Adam, Laura Díez-González, Alberto Ocaña, Boštjan Šeruga, Eitan Amir, Arnoud J Templeton
Telomere length (TL) has been associated with several health conditions including cancer. To quantify the effect of TL on outcomes in malignancies and explore the role of type of TL measurement we conducted a librarian-led systematic search of electronic databases identified publications exploring the prognostic role of TL on cancer outcomes. Overall survival (OS) was the primary outcome measure while other time-to-event endpoints were secondary outcomes. Data from studies reporting a hazard ratio (HR) with 95% confidence interval (CI) and/or p-value were pooled in a meta-analysis...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28506769/molecular-biomarkers-for-an-early-diagnosis-effective-treatment-and-prognosis-of-colorectal-cancer-current-updates
#6
REVIEW
Amjad Mahasneh, Fawaz Al-Shaheri, Eshraq Jamal
Colorectal cancer (CRC) is the third most prevalent cancer in the world. Globally, it has been estimated that about 1.4 million new cases of colorectal cancer are diagnosed every year. CRC is a multifactorial disease that arises due to genetics as well as epigenetic alterations in a number of oncogenes, tumor suppressor genes, mismatch repair genes, as well as cell cycle regulating genes in colon mucosal cells. These molecular alterations have been considered as potential CRC biomarkers because they can provide the physicians with diagnostic, prognostic and treatment response information...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28506768/low-expression-of-long-non-coding-rna-gas5-is-associated-with-poor-prognosis-of-patients-with-thyroid-cancer
#7
Ling-Ji Guo, Shu Zhang, Bo Gao, Yan Jiang, Xiao-Hua Zhang, Wu-Guo Tian, Shuai Hao, Jian-Jie Zhao, Gang Zhang, Chun-Yan Hu, Jie Yan, Dong-Lin Luo
The study aims to investigate the role of long non-coding RNA (lncRNA) GAS5 in the diagnosis and prognosis of patients suffering from thyroid cancer (TC). A total of 212 patients with TC and 61 patients with benign thyroid tumor were enrolled in the study. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to detect the lncRNA GAS5 expression in TC and benign tumor tissues. All TC patients were categorized into high-risk and low-risk groups according to the MACIS, AGES and AMES prognostic scoring system...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28506767/mig-6-is-down-regulated-in-hcc-and-inhibits-the-proliferation-of-hcc-cells-via-the-p-erk-cyclin-d1-pathway
#8
Zixuan Li, Lianyue Qu, Wenting Luo, Yulong Tian, Huan Zhai, Ke Xu, Hongshan Zhong
The ablation of Mig-6 has been shown to induce tumor formation in various tissues. However, the relationships between Mig-6 expression, clinical pathological factors, and prognosis have not been clarified in hepatocellular carcinoma (HCC), and the mechanism by which Mig-6 regulates the proliferation of HCC cells has not been reported. In this study, we investigated the clinical significance of the loss of Mig-6 expression in HCC and the mechanism underlying the inhibition of cell proliferation by Mig-6. The down-regulation of Mig-6 correlated significantly with large tumors, a more advanced BCLC stage, and a more advanced TNM stage, and low Mig-6 expression predicted significantly reduced survival...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28506766/effects-of-microrna-183-on-epithelial-mesenchymal-transition-proliferation-migration-invasion-and-apoptosis-in-human-pancreatic-cancer-sw1900-cells-by-targeting-mta1
#9
Xizhou Lin, Hongliang Song, Jun Xiao, Bujian Pan, Haichuan Chen, Xiaodan Jin, Haibo Yu
OBJECTIVE: This study aims to explore effects of miR-183 on epithelial-mesenchymal transition (EMT) and invasion by targeting MTA1 in human pancreatic cancer (PC) cells. METHODS: Totally, 108 PC patients admitted in Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University from March 2010 to March 2014 were enrolled. qRT-PCR and immunohistochemistry were applied to examine expression of MTA1 mRNA and protein. Samples were divided into 6 groups: blank, NC, miR-183 mimics, miR-183 inhibitors, MTA1-siRNA and miR-183 inhibitors +MTA1-siRNA groups...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28506765/augmenter-of-liver-regeneration-alr-exhibits-a-dual-signaling-impact-on-hepatic-acute-phase-response
#10
Rania Dayoub, Leonhard Buerger, Sara Ibrahim, Michael Melter, Thomas S Weiss
The acute-phase response (APR) is an inflammatory process triggered mainly by IL-6 in response to neoplasm, tissue injury, infection or inflammation. Signaling of IL-6 is transduced by activating STAT3 which rapidly results in production of acute-phase proteins (APPs) such as fibrinogen β (FGB) and haptoglobin (HP). Augmenter of liver regeneration (ALR), a hepatotrophic factor supporting liver regeneration, was reported to be upregulated after liver damage. In this study we analyzed the role of ALR for IL-6 signaling and APR...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28506764/specific-localization-of-lc3b-in-autophagosome-a-correlative-labelling-study-with-nanoparticle-in-oral-squamous-cell-carcinoma
#11
Kenneth Lai, Murray Killingsworth, Jim Yong, Slade Matthews, Ardalan Ebrahimi, John McGuinness, Quan Ngo, Nicole Caixeiro, Angela Hong, Cheok Soon Lee
No abstract text is available yet for this article.
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28506763/neonatal-hyperoxia-disrupts-the-intestinal-barrier-and-impairs-intestinal-function-in-rats
#12
Hsiu-Chu Chou, Chung-Ming Chen
Animal studies have demonstrated that neonatal hyperoxia injures the distal small intestine and disrupts the intestinal barrier. This study evaluated the effects of brief hyperoxia exposure on intestinal function in newborn rats. Newborn Sprague-Dawley rat pups were exposed to room air or normobaric hyperoxia (85% O2) for 1week. The rats were euthanized on Postnatal Day 7, and their terminal ilea and sera were collected for histological analyses and intestinal permeability measurements, respectively. Bacterial translocation to the liver and spleen under aerobic and anaerobic conditions was determined...
May 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28502582/upregulation-of-rad51-expression-is-associated-with-progression-of-thyroid-carcinoma
#13
R Sarwar, A K Sheikh, I Mahjabeen, K Bashir, S Saeed, M A Kayani
AIMS: RAD51 participates in homologous recombination repair (HRR) of double-stranded DNA breaks (DSBs) which may cause genomic instability and cancer. The aim of this study was to investigate RAD51 gene expression at transcriptional and translational levels to measure mRNA and protein level and to correlate its relationship with proliferation marker, Ki67 in thyroid cancer patients. This study also explored correlation of these genes with different clinicopathological parameters of the study cohort by Spearman's rank correlation coefficient...
May 11, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28499885/the-role-of-gilz-in-modulation-of-adaptive-immunity-in-a-murine-model-of-myocardial-infarction
#14
Babak Baban, Lin Yin, Xu Qin, Jun Yao Liu, Xingming Shi, Mahmood S Mozaffari
Myocardial infarction (MI) is associated with intense immune and inflammatory responses which contribute to tissue injury. Increasing evidence indicates that the glucocorticoid-induced leucine zipper (GILZ) protein suppresses immune and inflammatory responses. However, the status of and the role of GILZ in MI are not known. We tested the hypotheses that a) MI reduces cardiac GILZ associated with intense inflammation and cell death and b) intramyocardial GILZ delivery confers cardioprotection in association with increased Tregs and suppression of inflammation...
May 10, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28456661/trichinella-spiralis-impact-on-mesenchymal-stem-cells-immunohistochemical-study-by-image-analyzer-in-murine-model
#15
Marwa A Hasby Saad, Eiman A Hasby
This study aims to elucidate whether Trichinella spiralis infection or its crude antigen administration can stimulate recruitment of CD105(+ve)/CD45(-ve) cells that could represent MSCs in intestine and skeletal muscle of experimental BALB/c albino mice compared to healthy control mice. Studied mice were divided into: 20 healthy control, 20 with orally induced T. spiralis infection, 20 received adult worm crude antigen orally and 20 received larval crude antigen intramuscular. According to specific timing schedule, mice were sacrificed and tissue sections were examined for CD105 and CD45 immunohistochemical expression using image J image analyzing software, to compare different study groups...
April 27, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28454892/dna-damage-response-activation-and-cell-cycle-dysregulation-in-infiltrative-ameloblastomas-a-proposed-model-for-ameloblastoma-tumor-evolution
#16
Marina Gonçalves Diniz, Bruna Viana Antonini Guimarães, Núbia Braga Pereira, Grazielle Helena Ferreira de Menezes, Carolina Cavalieri Gomes, Ricardo Santiago Gomez
No abstract text is available yet for this article.
April 25, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28442375/implication-of-hyperoxaluria-on-osteopontin-and-er-stress-mediated-apoptosis-in-renal-tissue-of-rats
#17
Rishi Bhardwaj, Ankita Bhardwaj, Chanderdeep Tandon, Devinder K Dhawan, Rakesh Kumar Bijarnia, Tanzeer Kaur
Hyperoxaluria is a stress that leads to calcium oxalate crystal deposition which further causes inflammation and renal cell necroptosis. Many studies have linked osteopontin expression with apoptosis and inflammation but so far its association with apoptosis with regard to hyperoxaluria is undiscovered. Moreover, a recent report has suggested that osteopontin induces endoplasmic reticulum stress and subsequently apoptosis in myocytes. In this study, the impact of hyperoxaluria on the modulation of osteopontin expression and endoplasmic reticulum (ER) stress mediated apoptosis in rats is explored...
April 24, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28347704/high-glucose-induced-endothelial-to-mesenchymal-transition-in-human-umbilical-vein-endothelial-cell
#18
Chun-Hong Yu, Suriguga, Meng Gong, Wen-Juan Liu, Ning-Xuan Cui, Ying Wang, Xin Du, Zong-Chun Yi
BACKGROUND: Studies have shown that endothelial-to-mesenchymal transition (EndMT) could contribute to the progression of diabetic nephropathy, diabetic renal fibrosis, and cardiac fibrosis. The aim of this study was to investigate the influence of high glucose and related mechanism of MAPK inhibitor or specific antioxidant on the EndMT. METHODS: In vitro human umbilical vein endothelial cells (HUVEC) were cultured with 11mM, 30mM, 60mM and 120mM glucose for 0, 24, 48, 72 and 168h...
March 24, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28315688/fullerenol-nanoparticles-prevents-doxorubicin-induced-acute-hepatotoxicity-in-rats
#19
Vesna Jacevic, Aleksandar Djordjevic, Branislava Srdjenovic, Vukosava Milic-Tores, Zoran Segrt, Viktorija Dragojevic-Simic, Kamil Kuca
Doxorubicin (DOX), commonly used antineoplastic agent, affects bone marrow, intestinal tract and heart, but it also has some hepatotoxic effects. Main mechanism of its toxicity is the production of free reactive oxygen species. Polyhidroxilated C60 fullerene derivatives, fullerenol nanoparticles (FNP), act as free radical scavengers in in vitro systems. The aim of the study was to investigate potential FNP protective role against DOX-induced hepatotoxicity in rats. Experiments were performed on adult male Wistar rats...
March 16, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28315687/-10-gingerol-a-major-phenolic-constituent-of-ginger-root-induces-cell-cycle-arrest-and-apoptosis-in-triple-negative-breast-cancer-cells
#20
Megan M Bernard, Jason R McConnery, David W Hoskin
The ginger rhizome is rich in bioactive compounds, including [6]-gingerol, [8]-gingerol, and [10]-gingerol; however, to date, most research on the anti-cancer activities of gingerols have focused on [6]-gingerol. In this study, we compared [10]-gingerol with [8]-gingerol and [6]-gingerol in terms of their ability to inhibit the growth of human and mouse mammary carcinoma cells. A colorimetric assay based on the enzymatic reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide revealed that [10]-gingerol was more potent than [6]-gingerol and at least as potent as [8]-gingerol for the inhibition of triple-negative human (MDA-MB-231, MDA-MB-468) and mouse (4T1, E0771) mammary carcinoma cell growth...
March 16, 2017: Experimental and Molecular Pathology
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