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Endokrynologia Polska

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https://www.readbyqxmd.com/read/29645066/intellectual-performance-of-children-of-mothers-with-an-untreated-thyroid-disorder-in-the-first-pregnancy-trimester
#1
Irena Komendová, Sylvie Špitálníková
INTRODUCTION: The focus of the present study was the importance of the mother's thyroid function for foetal development in the first trimester, when the baby is totally dependent on the mother for thyroid hormones. MATERIAL AND METHODS: The study consisted in testing the intellectual performance of children with both euthyroid and thyroid-dysfunction mothers. The experimental group comprised 60 children of mothers with an untreated thyroid disorder in the first trimester of their pregnancy (TSH≥3...
April 12, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29645065/-131-i-mibg-therapy-of-malignant-pheochromocytoma-and-paraganglioma-tumors-a-single-center-study
#2
Agnieszka Kotecka-Blicharz, Kornelia Hasse-Lazar, Daria Handkiewicz-Junak, Tomasz Gawlik, Agnieszka Pawlaczek, Małgorzata Oczko-Wojciechowska, Barbara Michalik, Sylwia Szpak-Ulczok, Jolanta Krajewska, Beata Jurecka-Lubieniecka, Barbara Jarząb
INTRODUCTION: Pheochromocytomas and paragangliomas are rare tumors deriving from chromaffin cells of adrenal medulla or paraganglia. They are usually benign but 10-35% of them present malignant behavior. The aim of the study was to evaluate the efficacy and safety of 131-I MIBG therapy in malignant pheochromocytoma /paraganglioma patients (MPPGL). MATERIAL AND METHODS: 18 patients (7 women and 11 men) were included in this study. Between 2002 and 2016 they underwent 131-I MIBG therapy because of MPPGL and their medical data were analyzed retrospectively...
April 12, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29645064/adiponectin-expression-in-visceral-adiposity-is-an-important-determinant-of-insulin-resistance-in-morbid-obesity
#3
Anca Elena Sirbu, Laura Buburuzan, Steliana Kevorkian, Sorina Martin, Carmen Barbu, Catalin Copaescu, Bogdan Smeu, Simona Fica
INTRODUCTION: Visceral adiposity is associated with decreased serum adiponectin levels, peripheral resistance to insulin and an increased risk of cardio-metabolic complications. However, the link between adiponectin expression in visceral adipose tissue (VAT), its serum levels and metabolic protection is controversial. The aim of this study was to investigate the relationship between the adiponectin gene expression in VAT and clinical and metabolic parameters in patients with severe obesity...
April 12, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29504626/red-cell-distribution-width-a-new-marker-for-exacerbation-of-heart-failure-in-patients-with-hypothyroidism-following-radioiodine-therapy
#4
Agata Czarnywojtek, Nadia Sawicka-Gutaj, Izabela Miechowicz, Magdalena Borowska, Kosma Woliński, Maria Teresa Płazińska, Ariadna Zybek-Kocik, Ewa Straburzyńska-Migaj, Małgorzata Zgorzalewicz-Stachowiak, Aleksandra Hernik, Ewelina Szczepanek-Parulska, Marek Ruchała
INTRODUCTION: Cardiovascular diseases constitute a major cause of health problems and death in developed countries across the world. The increased value of the index of distribution of red blood cells volume (RDW) may be a prognostic marker in patients diagnosed with chronic heart failure (CHF). Hypothyroid patients present higher RDW values if compared to healthy controls. Taking into consideration that RDW might be both affected by thyroid status and CHF, we decided to determine the effect of concomitant hypothyroidism following radioiodine therapy (RIT) and CHF on hematological parameters...
March 5, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29504625/fractionated-dosage-of-radioiodine-for-the-ablation-of-differentiated-thyroid-cancer-has-no-impact-on-survival
#5
Kosma Woliński, Rafał Czepczyński, Adam Stangierski, Maciej Trojanowski, Magdalena Rewaj-Łosyk, Katarzyna Ziemnicka, Maciej Bączyk, Agnieszka Dyzmann-Sroka, Marek Ruchała
INTRODUCTION: Due to a limited number of hospital beds dedicated to radioiodine therapy (RIT) in some countries, a fractionated dose of radioiodine may be considered as the ablation therapy of differentiated thyroid cancer (DTC). The aim of the study was to compare the late effects of ablation therapy with single and fractionated dose of radioiodine in patients with DTC. PATIENTS AND METHODS: Patients with low-risk DTC referred to our institution 5-16 weeks after thyroidectomy, treated with 2...
March 5, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29465158/evaluation-of-adipokines-in-children-with-cystic-fibrosis
#6
Edyta Machura, Maria Szczepańska, Elżbieta Świętochowska, Franciszek Halkiewicz, Małgorzata Barć-Czarnecka, Katarzyna Ziora, Dariusz Ziora
INTRODUCTION: Patients with CF present numerous pathological conditions such as malnutrition, depletion of fat-free mass, metabolic disturbances (abnormal glucose metabolism, increased insulin resistance, chronic energy deficit, local and chronic inflammation), which could affect or be associated with altered adipokines concentrationMaterial and Methods: We aimed in this study to investigate the levels of selected adipokines such as resistin, apelin, adiponectin to demonstrate their application as possible markers of inflammation...
February 21, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29465157/serum-concentrations-of-adipokines-in-men-with-prostate-cancer-and-benign-prostate-hyperplasia
#7
Lucyna Siemińska, Artur Borowski, Bogdan Marek, Mariusz Nowak, Dariusz Kajdaniuk, Jakub Warakomski, Beata Kos-Kudła
INTRODUCTION: Obesity and prostate cancer are related, but the causal relationship remains unknown. The aim of the study was to compare concentrations of leptin, adiponectin and chemerin in patients with prostate cancer and benign prostate hyperplasia and to examine associations of the adipokines with the grade of prostate cancer, interleukin-6 (IL-6), insulin resistance and anthropometric and metabolic variables. MATERIAL AND METHODS: The study group consisted of 140 men divided into two groups: I- prostate cancer (n=74) and II- with benign hyperplasia (n=66)...
February 21, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29465156/the-impact-of-serum-adropin-and-ischemia-modified-albumin-levels-based-on-bmi-in-pcos
#8
Zeynep Ozturk Inal, Sami Erdem, Yavuz Gederet, Cevdet Duran, Zehra Kucukaydin, Huseyin Kurku, Derya Kilic Sakarya
INTRODUCTION: The aim of this study was to evaluate the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on serum adropin and ischemia modified albumin (IMA) levels. MATERIALS AND METHODS: This prospective cross-sectional study was performed with a total of 120 women [group1; non-PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30) and group 2; PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30)]. Blood samples were collected between the third and fifth days of the women's menstrual cycles after a night of fasting...
February 21, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29465155/effects-of-physical-activity-on-sclerostin-concentrations
#9
Małgorzata Janik, Michał Stuss, Marta Michalska-Kasiczak, Anna Jegier, Ewa Sewerynek
Osteoporosis is a serious medical and socioeconomic problem of the 21st century. Mechanical load is a key regulator which controls bone formation and remodelling, with participation of osteocytes. Sclerostin is produced and released by mature osteocytes into bone surface, where it inhibits the conveyance of osteoblast proliferation and differentiation activating signals from mesenchymal cells, thus suppressing new bone formation. The goal of the study was an evaluation of the effects of a 12-week physical training programme on the levels of bone turnover markers [Sclerostin, Osteocalcin (OC), C-terminal telopeptide of type I collagen (β-CTX)] in blood serum of women with osteopenia...
February 21, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29442353/the-effect-of-vitamin-d-supplementation-on-sexual-functioning-and-depressive-symptoms-in-young-women-with-low-vitamin-d-status
#10
Robert Krysiak, Anna Szwajkosz, Bogdan Marek, Bogusław Okopień
BACKGROUND: Hypovitaminosis D is associated with abnormal female sexual functioning. The aim of our study was to assess whether vitamin D supplementation affects sexual functioning and depressive symptoms in young women with low vitamin D status. METHODS: The study included 47 women with vitamin D deficiency or insufficiency. All women with vitamin D deficiency were treated with oral vitamin D, while women with vitamin D insufficiency were either treated with vitamin D or left untreated...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29442351/milk-alkali-syndrome-mas-as-a-complication-of-the-treatment-of-hypoparathyroidism
#11
Agata Skwarek, Janusz Pachucki, Tomasz Bednarczuk, Zuzanna Żurecka, Michał Popow
Milk-alkali syndrome (MAS), characterized by renal failure, metabolic alkalosis and hypercalcemia, is a severe and life-threatening complication of the treatment of hypoparathyroidism. The clinical course is often sudden and is not preceded by any prodromal symptoms. Occurrence does not depend on the duration of hypoparathyroidism treatment, although it is closely related to the applied therapy, especially the dose of calcium carbonate and active vitamin D preparations. Drugs influencing the glomerular filtration rate (angiotensin receptor blockers, sartans, aldosterone receptor antagonists, thiazide diuretics), lack of adequate routine control, changing the calcium carbonate supplementation, dehydration, a diet rich in pH-basic foods (i...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29442350/occult-phosphaturic-mesenchymal-tumor-of-femur-cortex-causing-oncogenic-osteomalacia-diagnostic-challenges-and-clinical-outcomes
#12
Deep Dutta, Raghuvansh Kumar Pandey, Rakhee Gogoi, Nagender Solanki, Renu Madan, Anupam Mondal, Shruti Dogra, Pradeep Thapa
BACKGROUND: Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia. PATIENT AND METHODS: 41- year gentleman with 4-year history of musculoskeletal weakness and pathologic fractures presented in wheelchair bound incapacitated state of 1-year duration. Investigations were significant for severe hypophosphatemia, severe phosphaturia, normal serum calcium, reduced 1,25-dihydroxy vitamin-D, elevated ALP, elevated intact parathyroid hormone (iPTH), and pseudo-fractures involving pelvis and bilateral femur...
February 14, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29334119/evaluation-of-four-variants-of-the-thyroid-imaging-reporting-and-data-system-tirads-classification-in-patients-with-multinodular-goiter
#13
Bartosz Migda, Michal Migda, Anna Marta Migda, Jacek Bierca, Jadwiga Slowniska-Srzednicka, Wieslaw Jakubowski, Rafal Zenon Slapa
Purpose The goal this study was to evaluate the utility of four variants of the Thyroid Imaging Reporting and Data System (TIRADS) in the differentiation of focal lesions in individuals with multinodular goiter. Materials and Methods The study was approved by the Local Bioethical Committee. Each patient gave informed consent before enrolment. A total of 163 nodules in 124 patients with multinodular goiter were evaluated by ultrasound. B-mode and PD imaging and strain elastography were performed. Archived images were evaluated via retrospective analysis using four different proposed TIRADS classifications Results Sensitivity and specificity of the Horvath, Park, Kwak, and Russ classifications were 0...
January 15, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29334118/markers-of-proliferation-and-invasiveness-in-somatotropinomas
#14
Agata Baldys-Waligorska, Iga Wierzbicka, Grzegorz Sokolowski, Dariusz Adamek, Filip Golkowski
IntroductionIn the search for markers of invasiveness of pituitary adenomas, we studied the expression of Ki-67 antigen, TOPO 2A (topoisomerase 2 alpha), AIP (Aryl Hydrocarbon Receptor-Interacting Protein) and VEGF (Vascular Endothelial Growth Factor) in somatotropinomas.Material and MethodsWe retrospectively studied a group of 31 patients who underwent pituitary tumour surgery. Expression of Ki-67, TOPO 2A, AIP and VEGF in surgical specimens was determined by immunohistochemistry. Relations between quantitatively determined markers and clinical symptoms, tumour features, and MR imaging, were analysed...
January 15, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29319131/temozolomide-therapy-for-aggressive-pituitary-crooke-s-cells-corticotropinoma-causing-cushing-s-disease-a-case-report-with-literature-review
#15
Aleksandra Gilis-Januszewska, Małgorzata Wilusz, Jacek Pantofliński, Renata Turek-Jabrocka, Grzegorz Sokołowski, Anna Sowa-Staszczak, Łukasz Kluczyński, Dorota Pach, Grzegorz Zieliński, Alicja Hubalewska-Dydejczyk
AbstractContext: Aggressive pituitary tumours causing Cushing's Disease are very rare, difficult to treat, and usually resistant to conventional therapy. There is growing evidence for the use of temozolomide (TZM), an alkylating chemotherapeutic agent, as first line chemotherapy in tumours resistant to repeated neurosurgery, radiotherapy and adrenalectomy. OBJECTIVE: To present the response to TMZ in a rare case of an aggressive pituitary tumour in the course of Cushing's Disease and to review the literature referring to similar cases...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29492952/discrimination-of-papillary-thyroid-cancer-from-non-cancerous-thyroid-tissue-based-on-lipid-profiling-by-mass-spectrometry-imaging
#16
Anna Wojakowska, Laura M Cole, Mykola Chekan, Katarzyna Bednarczyk, Magdalena Maksymiak, Małgorzata Oczko-Wojciechowska, Barbara Jarząb, Malcolm R Clench, Joanna Polańska, Monika Pietrowska, Piotr Widlak
INTRODUCTION: The distinction of papillary thyroid carcinomas from benign thyroid lesions has important implication for clinical man-agement. Classification based on histopathological features can be supported by molecular biomarkers, including lipidomic signatures, identified with the use of high-throughput mass spectrometry techniques. Formalin fixation is a standard procedure for stabilization and preservation of tissue samples, therefore this type of samples constitute highly valuable source of clinical material for retrospective molecular studies...
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29442352/guidelines-of-polish-national-societies-diagnostics-and-treatment-of-thyroid-carcinoma-2018-update
#17
Barbara Jarząb, Marek Dedecjus, Dorota Słowińska-Klencka, Andrzej Lewiński, Zbigniew Adamczewski, Ryszard Anielski, Maciej Bagłaj, Agata Bałdys-Waligórska, Marcin Barczyński, Tomasz Bednarczuk, Artur Bossowski, Monika Buziak-Bereza, Ewa Chmielik, Andrzej Cichocki, Agnieszka Czarniecka, Rafał Czepczyński, Janusz Dzięcioł, Tomasz Gawlik, Daria Handkiewicz-Junak, Kornelia Hasse-Lazar, Alicja Hubalewska-Dydejczyk, Krystian Jażdżewski, Beata Jurecka-Lubieniecka, Michał Kalemba, Grzegorz Kamiński, Małgorzata Karbownik-Lewińska, Mariusz Klencki, Beata Kos-Kudła, Agnieszka Kotecka-Blicharz, Aldona Kowalska, Jolanta Krajewska, Aleksandra Kropińska, Aleksandra Kukulska, Emilia Kulik, Andrzej Kułakowski, Krzysztof Kuzdak, Dariusz Lange, Aleksandra Ledwon, Elżbieta Lewandowska-Jabłońska, Katarzyna Łącka, Barbara Michalik, Anna Nasierowska-Guttmejer, Janusz Nauman, Marek Niedziela, Ewa Małecka-Tendera, Małgorzata Oczko-Wojciechowska, Tomasz Olczyk, Ewa Paliczka-Cieślik, Lech Pomorski, Zbigniew Puch, Józef Roskosz, Marek Ruchała, Dagmara Rusinek, Stanisław Sporny, Agata Stanek-Widera, Zoran Stojcev, Aleksandra Syguła, Anhelli Syrenicz, Sylwia Szpak-Ulczok, Tomasz Tomkalski, Zbigniew Wygoda, Jan Włoch, Ewa Zembala-Nożyńska
Significant advances have been made in thyroid can-cer research in recent years, therefore relevant clinical guidelines need to be updated. The current Polish guidelines "Diagnostics and Treatment of Thyroid Carcinoma" have been formulated at the "Thyroid Cancer and Other Malignancies of Endocrine Glands" conference held in Wisła in November 2015 [1].
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29319130/anaplastic-thyroid-carcinoma-with-rapid-thyrotoxicosis-a-case-report-and-the-literature-review
#18
Jacek Daroszewski, Katarzyna Paczkowska, Aleksandra Jawiarczyk-Przybyłowska, Marek Bolanowski, Michał Jeleń
INTRODUCTION: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of the malignant neoplasms of the thyroid gland. ATC usually manifests itself with the local symptoms due to a rapidly enlarging thyroid mass, and as other thyroid cancers, has only seldom been reported to cause thyrotoxicosis. Up to now only 9 cases of ATC with concomitant thyrotoxicosis have been described. CASE REPORT: We report a rare case of a 66-year-old woman, who had had the preexisting large, euthyroid multinodular goiter for almost 50 years...
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29319129/cerebellar-metastasis-of-papillary-thyroid-carcinoma-detected-with-somatostatin-receptor-scintigraphy
#19
Rafał Czepczyński, Anna Wyszomirska, Maria Gryczyńska, Ewelina Szczepanek-Parulska, Marek Ruchała
INTRODUCTION: Distant metastases of papillary thyroid carcinoma (PTC) may lack the ability to concentrate radioiodine. In such cases, positive somatostatin receptor scintigraphy might be useful in demonstrating the expression of somatostatin receptors that are potential therapeutic targets. To date, only a few cerebellar metastases from PTC have been reported in the literature. PATIENT FINDINGS: We present an 82-year-old female, in whom an asymptomatic cerebellar metastasis from PTC was diagnosed by means of Tc-99m-EDDA/HYNIC-TOC scintigraphy four years after the initial diagnosis...
2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29319128/a-preliminary-study-on-the-expression-and-clinical-value-of-platelet-derived-growth-factor-bb-hypoxia-inducible-factor-1%C3%AE-and-c-c-motif-chemokine-receptor-2-in-peripheral-blood-during-the-pathogenesis-of-graves-disease
#20
Ying Liu, Jinglan Tang, Qiaohong Hu, Kefeng Lu, Chunjie Hou
INTRODUCTION: Platelet-derived growth factor BB (PDGF-BB) plays an important role in the development of GD (Graves' disease). However, it is still unknown whether PDGF-BB is expressed in peripheral blood and whether the expression of PDGF-BB contributes to GD. We aim to study the expression of PDGF-BB, hypoxia inducible factor (HIF)-1α and C-C motif chemokine receptor (CCR)-2 in peripheral blood of patients with GD and explore its effect and potential mechanism in pathogenesis. MATERIAL AND METHODS: 41 patients with GD (GD group) and forty-five healthy people (control group) were chosen...
2018: Endokrynologia Polska
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