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Endokrynologia Polska

Marek Pawlikowski, Hanna Pisarek, Maria Jaranowska, Maciej Radek, Katarzyna Winczyk, Jolanta Kunert-Radek
INTRODUCTION: The pituitary adenomas secreting thyrotropin (TSH) are considered the rarest type of the hormonally active pituitary tumour. In spite of that, many cases are described in the literature. On the other hand, the observations of the co-expression of TSH with other pituitary hormones (mostly with growth hormone - GH) and "silent" expression of TSH in clinically nonfunctioning pituitary adenomas (CNFPA) are rather scarce. MATERIAL AND METHODS: Among 93 examined pituitary adenomas, 22 of them are diagnosed as active acromegaly and 71 as clinically nonfunctioning pituitary adenomas (CNFPA)...
July 12, 2016: Endokrynologia Polska
Nihal Yücel, Özlem Çakır Madenci, Aycan Bölük, Lale Köroğlu Dağdelen, Yusuf Temel, Mehmet Sargın, Asuman Orçun
INTRODUCTION: The relation of galectin-3 and diabetes mellitus or renal function have recently been investigated. In this study, we tried to evaluate the association of galectin-3 in urinary albumin excretion levels in type 2 diabetic patients. MATERIAL AND METHODS: In a total group of 137 type 2 diabetes patients, the mean of the last three urinary microalbumin/creatinine ratio and galectin-3 levels were evaluated. The patient group was divided into three subgroups according to their level of albuminuria calculated with urine microalbumin/creatinine ratio...
February 17, 2016: Endokrynologia Polska
Marlena Juszczak, Monika Wolak, Ewa Bojanowska, Lucyna Piera, Magdalena Roszczyk
INTRODUCTION: Melatonin exerts its biological role acting mainly via G protein-coupled membrane MT₁ and MT2 receptors. To determine whether a response of oxytocinergic neurons to different concentrations of melatonin is mediated through membrane MT₁ and/or MT₂ receptors, the effect of melatonin receptors antagonists, i.e. luzindole (a non-selective antagonist of both MT₁ and MT₂ receptors) and 4-phenyl-2-propionamidotetralin (4-P-PDOT - a selective antagonist of MT₂ receptor), on melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial (H-N) system, has been studied both in vitro and in vivo...
February 17, 2016: Endokrynologia Polska
Mustafa Altay, İhsan Ateş, Fatma Meriç Yılmaz, Canan Topçuoğlu, Mustafa Kaplan
INTRODUCTION: We aimed to investigate the role of sTWEAK in the pathogenesis of Hashimoto's thyroiditis which is a chronic inflammatory autoimmune disease. MATERIAL AND METHODS: A total of 80 patients were included in the study; 60 of which were newly diagnosed with Hashimoto's Thyroiditis (20 patients in each of the euthyroid, subclinical hypothyroid and overt hypothyroid subgroups), and 20 of which were healthy volunteers. Thyroid function tests and autoantibodies were measured using the electro-chemiluminescence immunoassay method and sTWEAK, IL-17A, IL-12 and TGF-β1 were measured using enzyme-linkedimmunosorbentassay method...
February 17, 2016: Endokrynologia Polska
Chiou Wen-Ko, Chen Szu-Tah, Liu Feng-Hsuan, Chang Chen-Nen, Wang Ming-Hsu, Lin Jen-Der
INDRODUCTION: An increased risk of mortality in patients with uncontrolled acromegaly has been reported in several studies. We aimed to assess the impact of co-morbidities on the survival of patients with acromegaly after long-term treatment and follow-up. MATERIAL AND METHODS: A retrospective analysis was performed for 285 patients with active acromegaly who were admitted to the Chang Gung Memorial Hospital, Taiwan between 1978 and 2012. Of these patients, 106 (37...
February 17, 2016: Endokrynologia Polska
Ariadna Zybek-Kocik, Nadia Sawicka-Gutaj, Elżbieta Wrotkowska, Jerzy Sowiński, Marek Ruchała
INTRODUCTION: Irisin, cleaved and secreted part of the transmembrane protein FNDC5, is a recently discovered adipo-myokine said to have a significant influence on body metabolism. Changes in thyrometabolic state may also alter serum irisin level. Since already reported data are not fully consistent, the aim of the present research is to evaluate the time-dependent changes in serum irisin level in patients affected by overt hypothyroidism. MATERIAL AND METHODS: Study involved 36 subjects - two groups of 12 patients with long-lasting (AITD) and short-term (TC) overt hypothyroidism, and control group (CG) of 12 subjects, matched for age and gender...
February 17, 2016: Endokrynologia Polska
Mustafa Demirpence, Hamiyet Yilmaz, Ayfer Colak, Hulya Yalcin, Burak Toprak, Hakan Turkon, Levent Ugurlu, Cengiz Aydin
INTRODUCTION: Irisin, a recently identified myokine, is associated with increased energy expenditure and has a potential role in obesity. Therefore, we investigated circulating irisin levels in morbidly obese patients undergoing sleeve gastrectomy (SG). MATERIAL AND METHODS: Thirty morbidly obese patients undergoing SG and 30 healthy subjects were included. All participants were evaluated at baseline and again at 3 months post-SG. Body weight and height, the lipid profile, and plasma glucose, HbA1c, insulin and irisin levels were measured at each visit...
February 17, 2016: Endokrynologia Polska
Idris Kuzu, Sayid Shafi Zuhur, Nazan Demir, Gokce Aktas, Feyza Yener Ozturk, Yuksel Altuntas
INTRODUCTION: Late-night salivary cortisol is a frequently used and easily implemented diagnostically valuable test for the diagnosis of overt Cushing's syndrome. The use of late-night salivary cortisol in the diagnosis of subclinical Cushing's syndrome is somewhat controversial. In this study, we aimed to determine the diagnostic value of late-night salivary cortisol in diagnosing subclinical Cushing's syndrome and compared it with 24-hour urinary free cortisol levels (UFC). MATERIAL AND METHOD: The study consisted of 33 cases of subclinical Cushing's syndrome, 59 cases of non-functioning adrenal adenoma and 41 control subjects...
February 17, 2016: Endokrynologia Polska
Ons Fekih, Sonia Triki, Jihene Rejeb, Fadoua Neffati, Wahiba Douki, Asma Ommezzine, Slaheddine Chouchane, Mohamed Neji Guediche, Ali Bouslama, Mohamed Fadhel Najjar
INTRODUCTION: Paraoxonase 1 (PON1) polymorphisms have been largely involved in diabetes complications. The aim of the study is to evaluate effects of PON1 polymorphisms (L55M and Q192R) on Diabetic nephropathy (DN). MATERIAL AND METHODS: The study involved 116 children and adolescents with Type 1 diabetes (T1D) and 91 healthy subjects. Albumin excretion rate (AER) was determined by immunoturbidimetry. PON1 activity was measured by a spectrophotometric method and genotyping of PON1 gene was assessed by multiplex PCR followed by RFLP...
February 17, 2016: Endokrynologia Polska
Łukasz Cieszyński, Monika Berendt-Obołończyk, Michał Szulc, Krzysztof Sworczak
Cushing's syndrome (CS) is defined as a constellation of clinical signs and symptoms occurring due to hypercortisolism. Cortisol excess may be endogenous or exogenous. The most common cause of CS is glucocorticoid therapy with supraphysiological (higher than in the case of substitution) doses used in various diseases (e.g. autoimmune). One possible CS cause is ectopic (extra-pituitary) ACTH secretion (EAS) by benign or malignant tumours. Since its first description in 1963, EAS aetiology has changed, i.e. as well as small cell lung cancer (SCLC), higher incidence in other malignancies has been reported...
2016: Endokrynologia Polska
Maciej Misołek, Ewa Niebudek-Bogusz, Joanna Morawska, Bogusława Orecka, Wojciech Ścierski, Grażyna Lisowska
The paper presents a case study of a transsexual patient who underwent a voice pitch elevation surgery performed in Poland for the first time. The human voice is a reflection of the working of hormones and human psyche. This fact is of particular importance in transsexualism, a disorder consisting in incongruence between the individual's biological sex and their identified gender. For many transsexual people, especially of the MTF (male to female) type, who have undergone hormonal and surgical sex change, the voice still presents a major problem, causing difficulties in everyday life...
2016: Endokrynologia Polska
Paulina Szyszka, Ashley B Grossman, Salvador Diaz-Cano, Krzysztof Sworczak, Dorota Dworakowska
Adrenocortical carcinoma is associated with a low cure rate and a high recurrence rate. The prognosis is poor, and at diagnosis 30-40% of cases are already metastatic. The current therapeutic options (surgical resection, followed by adjuvant mitotane treatment +/- chemotherapy) are limited, and the results remain unsatisfactory. Key molecular events that contribute to formation of adrenocortical cancer are IGF2 overexpression, TP53-inactivating mutations, and constitutive activation of the Wnt/b-catenin signalling pathway via activating mutations of the b-catenin gene...
2016: Endokrynologia Polska
Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski, John J Kopchick
The growth hormone (GH) and insulin-like growth factor (IGF) system plays an important role in the regulation of cell proliferation, differentiation, apoptosis, and angiogenesis. In terms of cell cycle regulation, the GH-IGF system induces signalling pathways for cell growth that compete with other signalling systems that result in cell death; thus the final effect of these opposed forces is critical for normal and abnormal cell growth. The association of the GH-IGF system with carcinogenesis has long been hypothesised, mainly based on in vitro studies and the use of a variety of animal models of human cancer, and also on epidemiological and clinical evidence in humans...
2016: Endokrynologia Polska
Elżbieta Andrysiak-Mamos, Ewa Żochowska, Agnieszka Kaźmierczyk-Puchalska, Michał Popow, Dorota Kaczmarska-Turek, Janusz Pachucki, Tomasz Bednarczuk, Anhelli Syrenicz
INTRODUCTION: Hypocalcaemia is a common postoperative complication, both after the resection of parathyroid adenoma associated with primary hyperparathyroidism and after total thyroidectomy due to thyroid cancer or nodular goitre. For a few years, in patients with postoperative hypoparathyroidism and severe hypocalcaemia, who cannot discontinue intravenous calcium preparations even with the use of high vitamin D doses, attempts have been made to add recombinant human parathormone (rhPTH) to the treatment schedule...
2016: Endokrynologia Polska
Magdalena Mitka, Michał Bednarek, Bogdan Kałużewski
INTRODUCTION: The SHOX gene has been mapped at the pseudoautosomal region 1 (PAR1) of chromosomes X (Xp22.33) and Y (Yp11.32). The loss of SHOX gene functionality is assumed to be responsible for the Leri-Weill syndrome formation and the disproportionate short stature (DSS). The SHOX gene rearrangements constitute the majority of cases of gene functionality loss. Therefore, a practical application of the method, which allows for the diagnostics of the gene rearrangements, becomes a primary issue...
2016: Endokrynologia Polska
Helena Jastrzębska, Magdalena Kochman, Zbigniew Bartoszewicz, Mariusz Ołtarzewski, Romuald Dębski, Wojciech Zgliczyński
INTRODUCTION: Pregnant women require about 250 μg of iodine daily. Hypothyroid women treated with L-thyroxine do not utilise iodine, and metabolism of L-thyroxine tablets is an additional source of iodine for their foetuses. The aim of the study was to evaluate the influence of iodine supplementation in hypothyroid pregnant women treated with L-thyroxine on neonate TSH concentration and maternal thyroid parameters. MATERIAL AND METHODS: Ninety-two pregnant women with primary hypothyroidism on adequate thyroid hormone replacement were voluntarily divided into two groups: "thyroxine" (n = 38) treated with L-thyroxine only, and "thyroxine + iodine" (n = 54) treated additionally with 150 μg/day of iodine since 10th gestational week...
2016: Endokrynologia Polska
Aleksandra Jawiarczyk-Przybyłowska, Jowita Halupczok-Żyła, Marek Bolanowski
INTRODUCTION: Klotho is a transmembrane protein that attenuates insulin/insulin-like growth factor-1 (IGF-1) signalling and appears to be involved in ageing. Recent data suggest that soluble a-Klotho (sKlotho) is also elevated in acromegaly. The aim of this study was to assess serum levels of sKlotho in patients in relation to the activity of the disease and to compare with the control group. MATERIAL AND METHODS: We studied 55 patients with acromegaly and 29 healthy controls (CG)...
2016: Endokrynologia Polska
Janusz Strzelczyk, Magdalena Szumska, Aleksandra Damasiewicz-Bodzek, Anna Krywult, Michał Długaszek, Justyna Czubilińska, Kaja Gawlik, Konrad Synowiec, Krystyna Tyrpień-Golder, Karolina Poczkaj, Beata Kos-Kudła
INTRODUCTION: The glycation process is a non-enzymatic modification of proteins occurring due to the reactions of reductive carbohydrates. The glycated residues lose their biological functions, and their removal process is ineffective. They accumulate, and as a result they cause an immunological response. The aim of this study was a determination of the concentrations of advanced glycation end-products and antibodies against carboxymethyl lysine (anti-CML) and carboxyethyl lysine (anti-CEL) in the sera of Graves' orbitopathy patients...
2016: Endokrynologia Polska
Lara Vera, Stefano Gay, Claudia Campomenosi, Sabrina Paolino, Giorgia Pera, Eleonora Monti, Lorenzo Mortara, Bruno Seriolo, Massimo Giusti
INTRODUCTION: After thyroidectomy and radioiodine therapy, patients with differentiated thyroid cancer (DTC) are indefinitely treated with levothyroxine (L-T4). Osteoporosis is a debated consequence of hypothyroxinaemia. The aim of this study was to evaluate bone mineral density (BMD) and fracture risk assessed by FRAX in a cohort of DTC women. MATERIAL AND METHODS: Seventy-four women with DTC (aged 56.5 ± 9.9 years) treated at the mean age of 51.9 ± 12.0 years were studied...
2016: Endokrynologia Polska
Edyta Cichocka, Anna Wietchy, Katarzyna Nabrdalik, Janusz Gumprecht
Insulin therapy is the most effective method of lowering blood glucose. Over 100 years have passed the studies for the optimisation of insulin action. To date, subcutaneous insulin administration has been the basic route of insulin delivery. The search for insulin therapy is simultaneously conducted in the following directions: the optimisation of insulin action, automatisation, and the decrease in the invasiveness of insulin delivery methods. The optimisation of insulin action has led to the discovery of ultra-rapid-acting human insulin analogues, ultra-long-acting human insulin analogues, and biosimilar insulin...
2016: Endokrynologia Polska
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