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Endokrynologia Polska

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https://www.readbyqxmd.com/read/28660988/clinical-and-immunological-changes-in-patients-with-active-moderate-to-severe-graves%C3%AC-orbitopathy-treated-with-very-low-dose-rituximab
#1
David Karasek, Lubica Cibickova, Marta Karhanova, Jana Kalitova, Jan Schovanek, Zdenek Frysak
INTRODUCTION: Glucocorticoids represent the therapy of choice for active and moderate-to-severe Graves̕ orbitopathy (GO). In some patients, rituximab, a monoclonal antibody against the cluster of differentiation (CD) 20 receptor of B-lymphocytes, can serve as a second-line or an alternative treatment. The effect of very low-doseof rituximabon the clinical activity of GO and corresponding clinical or laboratory changes is reported. MATERIAL AND METHODS: Changes of Clinical Activity Score (CAS) for GO, proptosis, levels of thyroid-stimulating hormone receptor antibodies, and depletion of CD19+ and CD20+ B-lymphocytes were determined in ten patients (two men and eight women) with active moderate-to-severe GO treated with a single 100-mg dose of rituximab...
June 29, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28660987/correlations-between-10-year-risk-of-death-from-cardiovascular-diseases-and-10-year-osteoporotic-fracture-risk-in-postmenopausal-women
#2
Anna Kawińska-Hamala, Andrzej Kawiński, Krzysztof Stanek, Michał Stuss, Ewa Sewerynek
INTRODUCTION: The goal was an evaluation of the correlation between 10-year risk of death from CVD and 10-year bone fracture risk (FRAX). MATERIAL AND METHODS: A total of 79 patients (Lodz, Poland), aged 50-83 years, consulted for osteoporosis were divided into two groups: study group - with osteoporosis (O; T-score ≤ -2.5SD) and control - without osteoporosis (T-sc > -2.5). Bone mineral density was evaluated by densitometric scanning of spine (L2-L4 T-score) and/or femoral neck (Neck T-score) and/or total hip (Total Hip T-score)...
June 29, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28660986/the-game-of-glial-fibrillary-acidic-and-s100-proteins-in-pituitary-adenomas-two-players-or-several
#3
Anca Maria Cimpean, Amalia Raluca Ceausu, Ana Corlan, Eugen Melnic, Andreea Adriana Jitariu, Marius Raica
INTRODUCTION: S100 protein and GFAP expression in pituitary adenomas tumour cells is not well known; few correlations with other prognostic or therapeutic factors have previously been reported in pituitary adenomas. We aim to elucidate their involvement in the pathogenesis of pituitary adenomas and to establish the correlation of their expression with different growth factors and growth factor receptors known to have a prognostic and/or therapeutic role. MATERIAL AND METHODS: Sixty-one cases of pituitary adenomas were immunohistochemically assessed for the expression of GFAP and S100 protein in both tumour cells and FS cells, in close relationship with hormone profile, and correlated with vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) expression, previously studied by our team...
June 29, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28604945/adrenal-tumour-bigger-than-5-cm-what-could-it-be-an-analysis-of-139-cases
#4
Andrzej Cichocki, Radoslaw Samsel, Lucyna Papierska, Katarzyna Roszkowska-Purska, Karolina Nowak, Zbigniew Jodkiewicz, Anna Kasperlik-Załuska
INTRODUCTION: There is an increasing number of adrenal being tumours discovered incidentally during imaging examinations performed for many different indications. Radiological findings suggesting adrenal pathology may be caused by true adrenal tumours or by other retroperitoneal masses. Generally, the larger the tumour, the higher the possibility of adrenal cancer. MATERIAL AND METHODS: Analysis of our data - 139 operations performed over 11 years (2004-2014) in patients with tumours in the adrenal area larger than 5 cm...
June 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28604944/the-influence-of-graves-orbitopathy-treatment-with-intravenous-glucocorticoids-on-adrenal-function
#5
Urszula Ambroziak, Gabriela Bluszcz, Tomasz Bednarczuk, Piotr Miśkiewicz
INTRODUCTION: Graves' orbitopathy (GO) is the commonest extrathyroidal feature of Graves' disease. For active, moderate to severe GO intravenous glucocorticoid pulse therapy (ivGCS) is the first-line treatment, which might be followed by oral glucocorticoid therapy. Glucocorticoid treatment, especially in the time of withdrawal, carries a risk of adrenal insufficiency. The aim of this study was to assess the pituitary-adrenal axis function in patients with GO before and at the cessation of ivGCS, and after further oral glucocorticoid therapy...
June 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28604943/adipokine-profile-in-patients-with-anorexia-nervosa
#6
Agnieszka Baranowska-Bik, Bogusława Baranowska, Lidia Martyńska, Anna Litwiniuk, Małgorzata Kalisz, Jan Kochanowski, Wojciech Bik
INTRODUCTION: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissue-derived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN. MATERIAL AND METHODS: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls...
June 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28585683/the-age-of-developing-diabetes-and-fto-polymorphisms-rs9939609-rs1421085-and-rs9930506
#7
Władysław Grzeszczak, Maciej Molsa, Marek Tłuczykont, Anna Markowicz, Ryszard Swoboda, Marta Biedak, Anna Kałuża, Sebastian Sirek, Krzysztof Strojek
INTRODUCTION: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people...
June 6, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28585682/the-usefulness-of-laparoscopic-adrenalectomy-in-the-treatment-of-adrenal-neoplasms-a-single-centre-experience
#8
Ryszard Pogorzelski, Sadegh Toutounchi, Ewa Krajewska, Patryk Fiszer, Agata Kącka, Mariusz Piotrowski, Małgorzata Szostek, Tomasz Wołoszko, Krzysztof Celejewski, Urszula Ambroziak, Tomasz Bednarczuk, Zbigniew Gałązka
INTRODUCTION: Adrenal neoplasms comprise about 10% of all tumours affecting this organ and constitute a significant, at first diagnostic and subsequently therapeutic, problem, especially since a relatively high proportion of neoplastic lesions are asymptomatic. The number of diagnosed metastases to adrenal glands is increasing. Surgical treatment involves both open surgery as well as laparoscopy. MATERIAL AND METHODS: There were 235 adrenalectomies performed at our centre due to various indications over the past four years...
June 6, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28585681/glucose-metabolism-disorders-in-patients-with-non-functioning-adrenal-adenomas-single-centre-experience
#9
Katarzyna Krzyżewska, Ewa Niemczuk, Bartosz Jakub Myśliwiec, Roman Junik
INTRODUCTION: The presence of glucose metabolism disorders and their possible correlation with degree of cortisol secretion were evaluated in patients with non-functioning adrenal incidentalomas (NFAIs). MATERIAL AND METHODS: The study group consisted of 131 patients with hormonally inactive adrenal incidentalomas. In each patient, besides hormonal and radiological evaluation, was assessed for fasting glucose and insulin concentrations, and the oral glucose tolerance test (OGTT) was performed in all participants without previous history of glucose disturbances...
June 6, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28585680/thyroid-cancer-post-radioactive-iodine-treatment-for-hyperthyroidism-case-series-and-review-of-the-literature
#10
Abdallah A Al Eyadeh, Khaldon M Al-Sarihin, Suzan M Etewi, Ahmed A Al-Omari, Rania Atallah Al-Asa'd, Fares Halim Haddad
INTRODUCTION: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI131 treatment for hyperthyroidism and to report the index cases' characteristics and management MATERIAL AND METHODS: A cohort of 264 patients who received RAI131 treatment for different causes of thyrotoxicosis were followed up over a period of 18 years (1996-2014) by physical exam, radiological evaluation and serial thyroid function tests. RESULTS: During the follow up period, three cases of thyroid cancer were identified...
June 6, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28585679/diagnostic-value-of-selected-biochemical-markers-in-the-detection-of-recurrence-of-medullary-thyroid-cancer-comparison-of-calcitonin-procalcitonin-chromogranin-a-and-carcinoembryonic-antigen
#11
Kosma Woliński, Jarosław Kaznowski, Aleksandra Klimowicz, Adam Maciejewski, Dagny Łapińska-Cwojdzińska, Edyta Gurgul, Adrian D Car, Marta Fichna, Paweł Gut, Maria Gryczyńska, Marek Ruchała
INTRODUCTION: Medullary thyroid cancer (MTC) is a malignancy of the thyroid gland, which derives from parafollicular C cells. Periodic measurement of biochemical markers of MTC remains a crucial part of patient follow-up and disease monitoring. The aim of the study was to compare the diagnostic value of four selected markers - calcitonin (Ct), procalcitonin (PCT), chromogranin A (CgA), and carcinoembryonic antigen (CEA). METHODS: Patients with histopathologically confirmed MTC hospitalised in a single department between January 2015 and December 2015 were included in the study...
June 6, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28553700/minimally-invasive-radioguided-parathyroid-surgery-using-low-dose-tc-99m-mibi-comparison-with-standard-high-dose
#12
Ali Jangjoo, Ramin Sadeghi, Zohreh Mousavi, Masoud Mohebbi, Mahtab Khaje, Mehdi Asadi
BACKGROUND: Surgery remains the most effective treatment for primary hyperparathyroidism (PHPT). Minimally invasive radioguided parathyroidectomy (MIRP) is a common technique for detecting and excising abnormal parathyroid glands. The aim of this study was to compare injections of low-dose and high-dose (99m) Tc methoxy isobutyl isonitrile (MIBI) for intraoperative localisation of parathyroid adenomas by means of a gamma probe in patients with primary hyperparathyroidism (PHPT). MATERIAL AND METHODS: Thirty patients with PHPT and a preoperative diagnosis of parathyroid adenoma were enrolled between 2010 and 2012...
May 29, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28353315/comparison-of-leukocyte-il6-expression-in-patients-with-gestational-diabetes-mellitus-gdm-diagnosed-by-the-polish-diabetes-association-pda-2011-and-2014-criteria
#13
Katarzyna Mac-Marcjanek, Andrzej Zieleniak, Lucyna Woźniak, Monika Źurawska-Kliś, Katarzyna Cypryk, Piotr Okła, Marzena Wójcik
INTRODUCTION: Controversial data exist in the literature regarding relationship of IL-6 with gestational diabetes mellitus (GDM), partially resulting from different criteria for GDM classification. In the present study, we revised this linkage by investigating leukocyte IL6 expression and its associations with clinical characteristics of patients diagnosed by the Polish Diabetes Association (PDA) 2011 and 2014 criteria. MATERIALS AND METHODS: 145 pregnant women underwent a 75 g 2-h OGTT and GDM was diagnosed according to the PDA 2011 and 2014 recommendations...
March 29, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28230891/parathyroid-hormone-serum-concentration-in-central-european-patients-with-non-ischemic-heart-failure-as-a-potential-marker-of-disease-severity-and-poor-prognosis
#14
Grzegorz Marcin Kubiak, Agnieszka Kolaszko, Ewa Nowalany-Kozielska
IntroductionParathyroid hormone (PTH) might be considered as a potential marker of disease severity and worse prognosis in heart failure (HF) patients. ObjectivesTo assess PTH, vitamin D, phosphorus (P) and total calcium (Ca2+) serum concentrations in Central European patients suffering from HF of non-ischemic origin compared to non-HF volunteers.To evaluate potential correlations among the enumerated parameters, established markers of worse prognosis and declared sun exposure. Patients and methodsSerum intact-PTH, 25-OH vitamin D, P and total Ca2+ concentrations were assessed in a group of HF patients and non-HF volunteers...
February 23, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28230890/effect-of-testosterone-replacement-therapy-on-vitamin-d-and-fgf-23-levels-in-congenital-hypogonadism
#15
Cem Haymana, Alper Sonmez, Aydogan Aydogdu, Serkan Tapan, Yalcin Basaran, Coskun Meric, Kamil Baskoy, Abdullah Taslipinar, Mahmut Ilker Yilmaz, Omer Azal
INTRODUCTION: Patients with hypogonadism are at increased risk of cardiac and metabolic diseases and osteoporosis. Vitamin D and Fibroblast growth factor-23 (FGF-23) play role in the regulation of bone mineral metabolism and endothelial functions. Low vitamin D levels are reported in hypogonadism, while there is no data about the effect of testosterone replacement therapy (TRT). We investigated the effect of TRT on vitamin D and FGF-23 levels along with endothelial functions and insulin resistance in hypogonadal patients...
February 23, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28819951/metformin-a-new-old-drug
#16
Marta Patrycja Wróbel, Bogdan Marek, Dariusz Kajdaniuk, Dominika Rokicka, Aleksandra Szymborska-Kajanek, Krzysztof Strojek
For many years metformin has been the gold standard in the treatment of type 2 diabetes. According to recommendations of the most important diabetes associations, this is the first-choice drug for use as monotherapy in patients with newly diagnosed type 2 diabetes. Metformin is also recommended in combined treatment when monotherapy is no longer effective. It is then combined with a sulfony-lurea, an incretin, flozin, or insulin, irrespective of the number of insulin injections per day. Besides its properties used in the treatment of diabetes, metformin has been treated for some time as a drug of a so-called pleiotropic activity, as each year brings new reports about its favourable effect in different conditions...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28819950/successful-eus-guided-ethanol-ablation-of-insulinoma-four-year-follow-up-case-report-and-literature-review
#17
Krzysztof Dąbkowski, Paula Gajewska, Kamila Walter, Magdalena Londzin-Olesik, Andrzej Białek, Elżbieta Andrysiak-Mammos, Beata Kos-Kudła, Teresa Starzyńska
INTRODUCTION: EUS-guided ethanol ablation of insulinoma is a new method of treatment of this neuroendocrine tumour. Ablation is recommended in patients who are poor surgical candidates or refuse surgery. We present a case of an 81-year-old female with symptomatic insulinoma, treated successfully with EUS-guided alcoholic ablation, along with a literature review including 28 other previously described cases. The effectiveness, safety of the therapy, and technical procedure-related issues are summarised...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28819949/addison-s-disease-concomitant-with-corticotropin-deficiency-and-pituitary-crh-resistance-a-case-report
#18
Krzysztof C Lewandowski, Katarzyna Malicka, Katarzyna Dąbrowska, Andrzej Lewiński
A 36-year-old woman was found to have a low morning ACTH concentration despite a history of Addison's disease. Past medical history: At the age of 23 years the subject developed Graves's disease, which was treated with radioiodine. At about the same time, she claimed to have two episodes of pancreatitis treated with cholecystectomy. About seven months later she was euthyroid on L-thyroxine (TSH 1.51 mIU/mL) but was admitted with hypotension, hyponatraemia (sodium 109 mmol/L), and low morning cortisol (119 nmol/L)...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28819948/the-role-of-selenium-in-thyroid-gland-pathophysiology
#19
Michał Stuss, Marta Michalska-Kasiczak, Ewa Sewerynek
It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium). Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28660996/models-of-cognitive-functions-with-respect-to-selected-parameters-of-functional-state-of-the-thyroid-gland-in-post-menopausal-women
#20
Mariusz Gujski, Jarosław Pinkas, Mariusz Witczak, Alfred Owoc, Iwona Bojar
INTRODUCTION: The objective of the study was the development of models of cognitive functions in a group of post-menopausal women, according to the concentration of the selected laboratory parameters evaluating the functional state of the thyroid gland. MATERIAL AND METHODS: The study was conducted during 2012-2014, and covered women aged 50-65 years, minimum two years after the last menstruation, without chronic diseases, cancerous diseases, mental disorders, addiction to drugs or alcohol, and who did not use hormone replacement therapy...
2017: Endokrynologia Polska
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