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Endokrynologia Polska

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https://www.readbyqxmd.com/read/29022650/sleep-related-breathing-disorders-in-patients-with-prader-willi-syndrome-depending-on-the-period-of-growth-hormone-treatment
#1
Agnieszka Lecka-Ambroziak, Małgorzata Jędrzejczak, Marta Wysocka-Mincewicz, Mieczysław Szalecki
INTRODUCTION: Sleep-related breathing disorders (SRBD) are commonly present in patients with Prader-Willi syndrome (PWS). Recombinant human growth hormone (rhGH) treatment is reported to improve breathing function in PWS, but the findings are not explicit. MATERIAL AND METHODS: Screening polysomnography- polygraphy (PSG), assessing nasal respiratory flow, respiratory effort, and blood oxygen saturation, was used. Group 1 - before rhGH therapy (n = 11, mean age 3...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022649/the-quality-of-semen-among-a-sample-of-young-healthy-men-from-lower-silesia-androls
#2
Marek Mędraś, Felicja Lwow, Paweł Jóźków, Leszek Szmigiero, Aleksandra Zagrodna, Ewa Zagocka, Małgorzata Słowińska-Lisowska
INTRODUCTION: Contrary to other parts of the continent, little information is available regarding semen quality among subjects from central and eastern Europe. MATERIAL AND METHODS: We evaluated semen profiles among a sample of men from an industrialised region of Poland. We directly invited 5000 healthy inhabitants of the region (aged 18-35 years; with unchecked fecundity) to participate in the study. Among the 500 who were eligible and willing to participate, we acquired detailed information and semen and blood samples from 177 subjects...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022648/probiotics-for-experimental-obesity-prevention-focus-on-strain-dependence-and-viability-of-composition
#3
Nazarii Kobyliak, Tetyana Falalyeyeva, Tetyana Beregova, Mykola Spivak
INTRODUCTION: a comparative animal study of the efficacy of intermittent short-course administration of lyophilised single-, three-, and live multistrain probiotic on obesity. METHODS: We included 70 rats divided into seven groups (n = 10 in each). Rats of group I were intact. Newborn rats of groups II-VII were injected with monosodium glutamate (MSG) (4 mg/g). Rats of group II (MSG-obesity group) were untreated. The group III-V received lyophilised monoprobiotics B...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022647/use-of-metformin-is-associated-with-lower-incidence-of-cancer-in-patients-with-type-2-diabetes
#4
Alicja Muszyńska-Ogłaza, Grażyna Zarzycka-Lindner, Henryka Olejniczak, Mirosława Polaszewska-Muszyńska, Roman Junik
INTRODUCTION: The objective of the study was to assess the influence of metformin on the prevalence of cancer and risk factors for the development of cancer, in patients with type 2 diabetes. MATERIALS AND METHODS: A total of 1063 patients, treated between October 2012 and March 2013 in the Diabetes and Endocrinology Centre in Bydgoszcz, were enrolled in the study. Only patients who were first diagnosed with diabetes and consecutively with cancer were included in the analysis...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022646/low-skeletal-mass-is-an-important-predictor-of-osteoporosis-in-hiv-infected-men-in-india
#5
Deep Dutta, Meha Sharma, Rahul Bansal, Neera Sharma, Umesh Chandra Garga, Atul Anand, Kumar Gaurav
INTRODUCTION: This study evaluated prevalence and predictors of osteoporosis and sarcopenia in men with HIV. MATERIAL AND METHODS: 220 men with HIV were screened, of which 115 men, 30-50 years-age, having at least 1-year follow-up, underwent hormonal and DEXA analysis. 40 controls were also evaluated. RESULTS: Males with HIV had significantly lower BMD and Z-scores at all sites. Osteoporosis was diagnosed in 64.35%; commonest site being radius total (49...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022645/the-significance-of-trip11-and-t3-signaling-pathway-in-renal-cancer-progression-and-survival-of-patients
#6
Piotr Popławski, Agnieszka Piekiełko-Witkowska, Alicja Nauman
INTRODUCTION: TRIP11 is a multifunctional protein localizing either to Golgi apparatus, acting as a golgin, or in the nucleus, acting as coactivator of transcription mediated by thyroid hormone receptor (THR) and hypoxia induced factor (HIF). Triiodothyronine (T3) regulates nuclear localization of TRIP11 by inducing its phosphorylation. The exact mechanism of this regulation unknown. The expressions of THR and HIF are disturbed in various cancers, including renal cell cancer (RCC). In this study we aimed to analyze: 1) the mechanism of T3-dependent subcellular localization of TRIP11; 2) the significance of TRIP11 and T3 signaling pathway in RCC progression...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022644/assessment-of-risk-factors-in-metastatic-recurrent-tall-cell-variant-of-papillary-thyroid-carcinoma
#7
Kursat Okuyucu, Engin Alagoz, Semra Ince, Nuri Arslan
INTRODUCTION: Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor. A great majority of the cases live a disease-free life with quite favorable prognosis. There are lots of variants of PTC and a few of them exhibit aggressive behaviour. Typical example is the tall cell variant (TCV). Patients experience a greater incidence of recurrence, nodal and extranodal metastases, tumor associated mortality than other variants of PTC. Studies related to TCV almost always compared it with its patient population of PTC according to risk factors and clinicopathologic features...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022643/the-efficiency-of-elastography-in-the-diagnostics-of-follicular-lesions-and-nodules-with-an-unequivocal-fna-result
#8
Martyna Wojtaszek-Nowicka, Dorota Słowińska-Klencka, Stanisław Sporny, Bożena Popowicz, Krzysztof Kuzdak, Lech Pomorski, Krzysztof Kaczka, Jan Sopiński, Mariusz Klencki
INTRODUCTION: The aim was to assess the usefulness of strain elastography (SEG) in the diagnostics of two groups of thyroid nodules (TNs): follicular lesions (FL) with low malignancy risk (< 20.0%) and low percentage of papillary carcinomas (PTCs) among cancers as well as TNs with unequivocal cytology (UC) and high percentage of PTCs among cancers. MATERIAL AND METHODS: 168 TNs were analysed and eventually surgically treated: 100 UC (50 benign and 50 malignant - 90...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022642/induction-of-puberty-with-human-chorionic-gonadotropin-hcg-followed-by-reversal-of-hypogonadotropic-hypogonadism-in-kallmann-syndrome
#9
Malgorzata Maria Pierzchlewska, Maciej Grzegorz Robaczyk, Ida Vogel
INTRODUCTION: Kallmann syndrome (KS) is a rare, congenital disorder combining hypogonadotropic hypogonadism (HH) due to GnRH-deficiency with anosmia. Traditionally thought to require lifelong therapy it turns out to be a reversible condition in some patients. CASE REPORT: We present a case of a 22-year old man with absent puberty due to KS, in whom genetic testing revealed heterozygosity for a mutation in the PROK2 gene. Pubertal development and virilisation was achieved by using human chorionic gonadotropin (hCG) injections followed by testosterone replacement...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022641/-familial-isolated-pituitary-adenomas-fipa-case-report-of-four-families-and-review-of-literature
#10
Joanna Elżbieta Malicka, Joanna Świrska, Maria Kurowska, Marta Dudzińska, Jerzy S Tarach
BackgroundThe majority of pituitary adenomas are sporadic, but about 5% of them occur in a familial setting, predominantly in multiple endocrine neoplasia type 1 and Carney complex. Familial isolated pituitary adenomas (FIPA), unrelated to the syndromes mentioned above, were also described. The clinical course of FIPA differs significantly from sporadic cases, and is characterized by a larger tumor size, more aggressive course and younger patients' age at the moment of recognition. ObjectivesThe aim of this retrospective study is to present 4 families in which two closely related people were diagnosed with pituitary adenomas...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28879653/primary-neuroendocrine-carcinoma-of-the-breast-the-report-of-four-cases
#11
Katarzyna Steinhof-Radwańska, Anna Barczyk, Piotr Powązka, Maciej Kajor, Zuzanna Dobrosz, Ewa Świątkowska-Szlachta, Joanna Pilch-Kowalczyk
Breast neuroendocrine tumours are rare, accounting for up to 5% of all breasts tumours and approximately 1% of all neuroendocrine tumours. In most cases, breast neuroendocrine tumours are histologically and moderately well differentiated. Neuroendocrine breast tumours lack characteristic imaging patterns. The histopathological assessment of these tumours is difficult, and in most cases the correct diagnosis is made after proper examination of the postsurgical specimen.
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28879652/primary-squamous-cell-thyroid-carcinoma-a-successful-treatment-with-five-year-follow-up
#12
Andrzej Wygoda, Tomasz Rutkowski, Bogna Szcześniak-Kłusek, Jolanta Mrochem-Kwarciak, Maja Jędrzejewska, Krzysztof Składowski
Squamous cell carcinoma is an extremely rare neoplasm of the thyroid (SCTC) that represents no more than 1% of all primary thyroid malignancies. We report a case of a 42-year-old woman with rapidly growing mass in the right lower neck, primarily diagnosed in fine-needle aspiration cytology as a low-differentiated carcinoma. After the surgery, exclusion of all the other possible primary tumour locations, and immunohistochemistry tests, the diagnosis of primary squamous cell carcinoma of the thyroid gland was established...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28879651/preliminary-studies-on-the-differential-expression-of-adrenocorticotropic-hormone-receptor-in-adrenal-adenomas
#13
Dongliang Hu, Tongzu Liu, Xinghuan Wang
INTRODUCTION: The ACTH receptor (ACTHR) is primarily expressed in the adrenal cortex. Previous studies focused on the regulatory function of ACTHR in glucocorticoid secretion, but research on adrenal tumours is rare. The aim of this study was to evaluate ACTHR expression in common adrenal adenomas and investigate its influence on adrenal tumorigenesis using adrenocortical H295R cells. MATERIALS AND M: ETHODS: Real-time polymerase chain reaction and western blot were used to detect the expression of ACTHR in 18 aldosterone-producing adenomas, 16 cortisol-producing adenomas, nine non-functional adenomas, and 12 normal adrenal samples...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28879650/vascular-and-cardiac-function-in-young-adults-with-classical-congenital-adrenal-hyperplasia
#14
Joanna Wierzbicka-Chmiel, Artur Chmiel, Sławomir Rychlik, Monika Ogrodowczyk-Bobik, Bogdan Marek, Dariusz Kajdaniuk
INTRODUCTION: Patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk, but the vascular and cardiac function during longitudinal corticoids replacement therapy is not known thoroughly. MATERIAL AND METHODS: Cross-sectional study of 19 Caucasian adults with CAH (age 23.7 ± 3.8 years; twelve males) compared to 20 healthy volunteers matched for origin, sex, age, and body mass index (BMI). All of the participants were assessed for flow mediated dilatation of the brachial artery (FMD), intima-media thickness of the common carotid artery (cIMT) and common femoral artery (fIMT), standard echocardiography, and global longitudinal left ventricular function using two-dimensional speckle-tracking echocardiography (LSTE)...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28879649/melatonin-receptor-1b-gene-polymorphism-rs10830963-and-gestational-diabetes-mellitus-among-a-chinese-population-a-meta-analysis-of-association-studies
#15
Xiaolin Lu, Xiuying Yao, Xinli Liu, Yu Xin, Linlin Zhao, Zhen Wang, Mingming Cui, Lihua Wu, Shaofang Shangguan, Shaoyan Chang, Ting Zhang, Li Wang
INTRODUCTION: Studies have been conducted to investigate the association between rs10830963 of MTNR1B and the risk of gestational diabetes mellitus (GDM), but with inconclusive results. We aimed to clarify these controversies, especially with regard to the association in the Chinese population. MATERIAL AND METHODS: A systemic literature reference search inclusive to August 12, 2016 yielded 35 articles, from which 11 studies met the inclusion criteria for the final meta-analysis, including 3889 patients with GDM and 6708 controls...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28879648/is-there-any-difference-in-acromegaly-and-other-chronic-disease-in-quality-of-life-and-psychiatric-morbidity
#16
Dorota Maria Szcześniak, Aleksandra Jawiarczyk-Przybyłowska, Łukasz Matusiak, Anna Bolanowska, Julian Maciaszek, Małgorzata Siemińska, Joanna Rymaszewska, Marek Bolanowski
INTRODUCTION: The study aimed to evaluate the psychological profile of patients with acromegaly in comparison to other chronic diseases such as non-functioning pituitary adenomas, Cushing disease, plaque psoriasis, and to the healthy control group. MATERIALS AND METHODS: A total sample of 153 participants in clinical groups underwent a cross-sectional assessment including the quality of life (AcroQoL, WHOQoL-BREF), psychiatric morbidity (GHQ-28) and the acceptance of illness (AIS) and 65 participants in the healthy control group...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28879647/evaluation-of-vitamin-d-concentration-in-a-population-of-young-healthy-women-effects-of-vitamin-d-supplementation
#17
Ewa Sewerynek, Karol Cieślak, Małgorzata Janik, Ewelina Gowin, Michał Stuss
The goal of the study was an evaluation of serum vitamin D concentrations in healthy young women. MATERIAL AND METHODS: 106 healthy women, aged 20-30 years, were included in the study. Monthly evaluation - for three months - of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women with baseline values of vit. D < 20 ng/ml (Group 1) plus the effects of 800 IU/d dose in women with the baseline value of D > 20 ng/ml (Group2). Additionally, calcium and PTH concentrations were assessed at the study onset and after a 3-month supplementation...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28879646/acromegaly-treatment-in-romania-how-close-are-we-to-disease-control
#18
Dan Alexandru Niculescu, Ionela Florina Baciu, Cristina Capatina, Simona Andreea Galoiu, Monica Livia Gheorghiu, Serban Radian, Raluca Alexandra Trifanescu, Andra Caragheorgheopol, Mihail Coculescu, Catalina Poiana
INTRODUCTION: In Romania no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral center which covers an important part of Romanian territory and population of patients with acromegaly. MATERIAL AND METHODS: We reviewed the records of all 164 patients (49 males and 115 female; median age 55 (47, 63.5) years) with newly or previously diagnosed acromegaly who have been assessed at least once in our tertiary referral center between January 1st, 2012 and March 31st, 2016...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28660988/clinical-and-immunological-changes-in-patients-with-active-moderate-to-severe-graves%C3%AC-orbitopathy-treated-with-very-low-dose-rituximab
#19
David Karasek, Lubica Cibickova, Marta Karhanova, Jana Kalitova, Jan Schovanek, Zdenek Frysak
INTRODUCTION: Glucocorticoids represent the therapy of choice for active and moderate-to-severe Graves̕ orbitopathy (GO). In some patients, rituximab, a monoclonal antibody against the cluster of differentiation (CD) 20 receptor of B-lymphocytes, can serve as a second-line or an alternative treatment. The effect of very low-doseof rituximabon the clinical activity of GO and corresponding clinical or laboratory changes is reported. MATERIAL AND METHODS: Changes of Clinical Activity Score (CAS) for GO, proptosis, levels of thyroid-stimulating hormone receptor antibodies, and depletion of CD19+ and CD20+ B-lymphocytes were determined in ten patients (two men and eight women) with active moderate-to-severe GO treated with a single 100-mg dose of rituximab...
June 29, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28660986/the-game-of-glial-fibrillary-acidic-and-s100-proteins-in-pituitary-adenomas-two-players-or-several
#20
Anca Maria Cimpean, Amalia Raluca Ceausu, Ana Corlan, Eugen Melnic, Andreea Adriana Jitariu, Marius Raica
INTRODUCTION: S100 protein and GFAP expression in pituitary adenomas tumour cells is not well known; few correlations with other prognostic or therapeutic factors have previously been reported in pituitary adenomas. We aim to elucidate their involvement in the pathogenesis of pituitary adenomas and to establish the correlation of their expression with different growth factors and growth factor receptors known to have a prognostic and/or therapeutic role. MATERIAL AND METHODS: Sixty-one cases of pituitary adenomas were immunohistochemically assessed for the expression of GFAP and S100 protein in both tumour cells and FS cells, in close relationship with hormone profile, and correlated with vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) expression, previously studied by our team...
June 29, 2017: Endokrynologia Polska
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