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Endokrynologia Polska

Marzena Dębska, Małgorzata Gietka-Czernel, Piotr Kretowicz, Dagmara Filipecka-Tyczka, Łukasz Lewczuk, Joanna Dangel, Romuald Dębski
AbstractIntroduction: Fetal hypothyroidism negatively impacts somatic and neurological child development and can be the cause of serious obstetrical and perinatal complications. We present a rare case of a large fetal dyshormonogenetic goiter, causing fetal neck hyperextension, esophageal compression and cardiac high-output failure. MATERIAL AND METHODS: The fetal goiter complicated by cardiomegaly and polyhydramnios was diagnosed at 23 week of gestation (WG) on a routine ultrasonographic (US) assessment in a healthy nullipara...
June 29, 2018: Endokrynologia Polska
Dayan Cheng, Han Gao, Wentao Li
Rosiglitazone has been proposed as a treatment strategy for type 2 diabetes mellitus (T2DM), could provide robust glucose-lowering capability with risk of cardiovascular events. We thus did a systematic review and meta-analysis of controlled trials to assess the effect of this treatment on glycaemic control, cardiovascular events in patients with T2DM. We systematically search PubMed, Embase and Cochrane Central Register of Controlled Trials comparing rosiglitazone to other anti-diabetic treatments. These studies included randomized controlled trials (RCTs), cohort studies, and case-control studies that had treatment at least 6 months of follow-up in patients with T2DM...
June 28, 2018: Endokrynologia Polska
Dagmar Horakova, Ladislav Stepanek, Radka Nagelova, Dalibor Pastucha, Katerina Azeem, Helena Kollarova
INTRODUCTION: Adiponectin is a peptide secreted by adipocytes, whose reduction is connected with obesity-related diseases, including insulin resistance. The study analyzed levels of total adiponectin and its high molecular weight (HMW) oligomer in a group of metabolically healthy adults and in patients with type 2 diabetes mellitus (T2DM) to evaluate these levels as potential predictors of the development of insulin resistance. Material and mehods: The study comprised 269 metabolically healthy adults and 300 patients with T2DM...
June 28, 2018: Endokrynologia Polska
Ana Savic-Radojevic, Ilijana Mazibrada, Tatjana Djukic, Zoran B Stankovic, Marija Pljesa-Ercegovac, Katarina Sedlecky, Jelica Bjekic-Macut, Tatjana Simic, George Mastorakos, Djuro Macut
INTRODUCTION: It has been supposed that endocrine disturbances might be responsible for PCOS-associated oxidative stress, with special emphasis on hyperandrogenism.Considering potential relationship between hyperandrogenism and increased free radicals production, parameters of oxidative stress were determined in non-obese normoinsulinemic adolescent girls newly diagnosed with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS: Nitrotyrosine, thiol groups' concentrations, glutathione peroxidase and superoxide dismutase activities were determined under fasting conditions and during oral glucose tolerance test (OGTT) in 35 PCOS patients and 17 controls...
June 28, 2018: Endokrynologia Polska
Haiyang Lin, Minqiao Zheng, Xiaojie Mao, Xuewen Feng, Jing Li, Gaofeng Rao, Fang Lin
INTRODUCTION: Oxytocin might be used therapeutically as an ally to rescue osteopathy resulting from diabetes. However, the in vivo effect of oxytocin on marrow adipogenesis in diabetes remains unknown. In this longitudinal study, we aimed to investigate the protective effects of oxytocin on diabetes-induced marrow adiposity in rabbits using proton MR spectroscopy. MATERIALS AND METHODS: Forty-five female New Zealand rabbits were randomly divided into controls, diabetes and diabetes treated with oxytocin (ip, 0...
June 28, 2018: Endokrynologia Polska
Ryszard Pogorzelski, Sadegh Toutounchi, Urszula Ambroziak, Ewa Krajewska, Tomasz Wołoszko, Krzysztof Celejewski, Małgorzata Legocka, Małgorzata Szostek, Wawrzyniec Jakuczun, Przemysław Kwasiborski, Zbigniew Gałązka, Ewelina Biskup
lectomies were performed in the Department of General and Endocrine Surgery of the MUW. Hypercortisolemia was found in 50 (14%) patients, while overt hypercortisolemia in 31 patients. In the hypercortisolemia group, ACTH-dependent hypercortisolemia was diagnosed in 5 (10%) and ACTH-independent hypercortisolemia in 25 patients (50%). 1 patient with overt hypercortisolemia had cancer of the adrenal cortex. Remaining 19 (38%) patients had subclinical Cushing's syndrome. For our study, we compared patients with ACTH-independent hypercortisolemia (n=25) with those with Cushing's syndrome (n=19)...
June 28, 2018: Endokrynologia Polska
Elżbieta Wojarska-Tręda, Krzysztof Olejnik, Zoran Stojcev, Szymon Białka, Hanna Misiołek
BACKGROUND: The aim of this study was to compare hormonal stress responses (changes in adrenaline, noradrenaline and cortisol concentrations) to surgical injury during total intravenous propofol anesthesia and volatile anesthesia with sevoflurane in patients subjected to anterior resection of the rectum. METHODS: The prospective randomized study included 61 patients qualified for anterior resection of the rectum. The subjects were randomized into two groups, based on the type of anesthesia: 1) Group I (TIVA, n=31), administered total intravenous propofol anesthesia, and 2) Group II (VIMA, n=30), administered volatile induction and maintenance sevoflurane anesthesia...
June 28, 2018: Endokrynologia Polska
Jing Chen, Yingli Chen, Linong Ji, Puhong Zhang, Dongshan Zhu, Xian Li, Jiachao Ji, Fang Zhao, Heng Zhang
BACKGROUND: Type-2 diabetes mellitus (T2DM) is one of the most common diseases that endangers public health. T2DM may lead to diabetes-related microvascular complications, which in turn play a major role in exacerbating macrovascular complications. AIMS: This study evaluates an insulin dose titration model and factors that impact insulin dose adjustment in Chinese adults with type-2 diabetes, who receive basal insulin in real-world settings. METHODS: A total of 19,894 patients from the ORBIT study were included...
June 28, 2018: Endokrynologia Polska
Irena Komendová, Sylvie Špitálníková
INTRODUCTION: The focus of the present study was the importance of the mother's thyroid function for foetal development in the first trimester, when the baby is totally dependent on the mother for thyroid hormones. MATERIAL AND METHODS: The study consisted in testing the intellectual performance of children with both euthyroid and thyroid-dysfunction mothers. The experimental group comprised 60 children of mothers with an untreated thyroid disorder in the first trimester of their pregnancy (TSH≥3...
April 12, 2018: Endokrynologia Polska
Agnieszka Kotecka-Blicharz, Kornelia Hasse-Lazar, Daria Handkiewicz-Junak, Tomasz Gawlik, Agnieszka Pawlaczek, Małgorzata Oczko-Wojciechowska, Barbara Michalik, Sylwia Szpak-Ulczok, Jolanta Krajewska, Beata Jurecka-Lubieniecka, Barbara Jarząb
INTRODUCTION: Pheochromocytomas and paragangliomas are rare tumors deriving from chromaffin cells of adrenal medulla or paraganglia. They are usually benign but 10-35% of them present malignant behavior. The aim of the study was to evaluate the efficacy and safety of 131-I MIBG therapy in malignant pheochromocytoma /paraganglioma patients (MPPGL). MATERIAL AND METHODS: 18 patients (7 women and 11 men) were included in this study. Between 2002 and 2016 they underwent 131-I MIBG therapy because of MPPGL and their medical data were analyzed retrospectively...
April 12, 2018: Endokrynologia Polska
Anca Elena Sirbu, Laura Buburuzan, Steliana Kevorkian, Sorina Martin, Carmen Barbu, Catalin Copaescu, Bogdan Smeu, Simona Fica
INTRODUCTION: Visceral adiposity is associated with decreased serum adiponectin levels, peripheral resistance to insulin and an increased risk of cardio-metabolic complications. However, the link between adiponectin expression in visceral adipose tissue (VAT), its serum levels and metabolic protection is controversial. The aim of this study was to investigate the relationship between the adiponectin gene expression in VAT and clinical and metabolic parameters in patients with severe obesity...
April 12, 2018: Endokrynologia Polska
Agata Czarnywojtek, Nadia Sawicka-Gutaj, Izabela Miechowicz, Magdalena Borowska, Kosma Woliński, Maria Teresa Płazińska, Ariadna Zybek-Kocik, Ewa Straburzyńska-Migaj, Małgorzata Zgorzalewicz-Stachowiak, Aleksandra Hernik, Ewelina Szczepanek-Parulska, Marek Ruchała
INTRODUCTION: Cardiovascular diseases constitute a major cause of health problems and death in developed countries across the world. The increased value of the index of distribution of red blood cells volume (RDW) may be a prognostic marker in patients diagnosed with chronic heart failure (CHF). Hypothyroid patients present higher RDW values if compared to healthy controls. Taking into consideration that RDW might be both affected by thyroid status and CHF, we decided to determine the effect of concomitant hypothyroidism following radioiodine therapy (RIT) and CHF on hematological parameters...
March 5, 2018: Endokrynologia Polska
Kosma Woliński, Rafał Czepczyński, Adam Stangierski, Maciej Trojanowski, Magdalena Rewaj-Łosyk, Katarzyna Ziemnicka, Maciej Bączyk, Agnieszka Dyzmann-Sroka, Marek Ruchała
INTRODUCTION: Due to a limited number of hospital beds dedicated to radioiodine therapy (RIT) in some countries, a fractionated dose of radioiodine may be considered as the ablation therapy of differentiated thyroid cancer (DTC). The aim of the study was to compare the late effects of ablation therapy with single and fractionated dose of radioiodine in patients with DTC. PATIENTS AND METHODS: Patients with low-risk DTC referred to our institution 5-16 weeks after thyroidectomy, treated with 2...
March 5, 2018: Endokrynologia Polska
Edyta Machura, Maria Szczepańska, Elżbieta Świętochowska, Franciszek Halkiewicz, Małgorzata Barć-Czarnecka, Katarzyna Ziora, Dariusz Ziora
INTRODUCTION: Patients with CF present numerous pathological conditions such as malnutrition, depletion of fat-free mass, metabolic disturbances (abnormal glucose metabolism, increased insulin resistance, chronic energy deficit, local and chronic inflammation), which could affect or be associated with altered adipokines concentrationMaterial and Methods: We aimed in this study to investigate the levels of selected adipokines such as resistin, apelin, adiponectin to demonstrate their application as possible markers of inflammation...
February 21, 2018: Endokrynologia Polska
Lucyna Siemińska, Artur Borowski, Bogdan Marek, Mariusz Nowak, Dariusz Kajdaniuk, Jakub Warakomski, Beata Kos-Kudła
INTRODUCTION: Obesity and prostate cancer are related, but the causal relationship remains unknown. The aim of the study was to compare concentrations of leptin, adiponectin and chemerin in patients with prostate cancer and benign prostate hyperplasia and to examine associations of the adipokines with the grade of prostate cancer, interleukin-6 (IL-6), insulin resistance and anthropometric and metabolic variables. MATERIAL AND METHODS: The study group consisted of 140 men divided into two groups: I- prostate cancer (n=74) and II- with benign hyperplasia (n=66)...
February 21, 2018: Endokrynologia Polska
Zeynep Ozturk Inal, Sami Erdem, Yavuz Gederet, Cevdet Duran, Zehra Kucukaydin, Huseyin Kurku, Derya Kilic Sakarya
INTRODUCTION: The aim of this study was to evaluate the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on serum adropin and ischemia modified albumin (IMA) levels. MATERIALS AND METHODS: This prospective cross-sectional study was performed with a total of 120 women [group1; non-PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30) and group 2; PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30)]. Blood samples were collected between the third and fifth days of the women's menstrual cycles after a night of fasting...
February 21, 2018: Endokrynologia Polska
Małgorzata Janik, Michał Stuss, Marta Michalska-Kasiczak, Anna Jegier, Ewa Sewerynek
Osteoporosis is a serious medical and socioeconomic problem of the 21st century. Mechanical load is a key regulator which controls bone formation and remodelling, with participation of osteocytes. Sclerostin is produced and released by mature osteocytes into bone surface, where it inhibits the conveyance of osteoblast proliferation and differentiation activating signals from mesenchymal cells, thus suppressing new bone formation. The goal of the study was an evaluation of the effects of a 12-week physical training programme on the levels of bone turnover markers [Sclerostin, Osteocalcin (OC), C-terminal telopeptide of type I collagen (β-CTX)] in blood serum of women with osteopenia...
February 21, 2018: Endokrynologia Polska
Robert Krysiak, Anna Szwajkosz, Bogdan Marek, Bogusław Okopień
BACKGROUND: Hypovitaminosis D is associated with abnormal female sexual functioning. The aim of our study was to assess whether vitamin D supplementation affects sexual functioning and depressive symptoms in young women with low vitamin D status. METHODS: The study included 47 women with vitamin D deficiency or insufficiency. All women with vitamin D deficiency were treated with oral vitamin D, while women with vitamin D insufficiency were either treated with vitamin D or left untreated...
February 14, 2018: Endokrynologia Polska
Agata Skwarek, Janusz Pachucki, Tomasz Bednarczuk, Zuzanna Żurecka, Michał Popow
Milk-alkali syndrome (MAS), characterized by renal failure, metabolic alkalosis and hypercalcemia, is a severe and life-threatening complication of the treatment of hypoparathyroidism. The clinical course is often sudden and is not preceded by any prodromal symptoms. Occurrence does not depend on the duration of hypoparathyroidism treatment, although it is closely related to the applied therapy, especially the dose of calcium carbonate and active vitamin D preparations. Drugs influencing the glomerular filtration rate (angiotensin receptor blockers, sartans, aldosterone receptor antagonists, thiazide diuretics), lack of adequate routine control, changing the calcium carbonate supplementation, dehydration, a diet rich in pH-basic foods (i...
February 14, 2018: Endokrynologia Polska
Deep Dutta, Raghuvansh Kumar Pandey, Rakhee Gogoi, Nagender Solanki, Renu Madan, Anupam Mondal, Shruti Dogra, Pradeep Thapa
BACKGROUND: Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia. PATIENT AND METHODS: 41- year gentleman with 4-year history of musculoskeletal weakness and pathologic fractures presented in wheelchair bound incapacitated state of 1-year duration. Investigations were significant for severe hypophosphatemia, severe phosphaturia, normal serum calcium, reduced 1,25-dihydroxy vitamin-D, elevated ALP, elevated intact parathyroid hormone (iPTH), and pseudo-fractures involving pelvis and bilateral femur...
February 14, 2018: Endokrynologia Polska
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