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Endokrynologia Polska

Aleksandra Zdrojowy-Wełna, Katarzyna Zatońska, Grażyna Bednarek-Tupikowska, Alicja Jokiel-Rokita, Katarzyna Kolackov, Andrzej Szuba, Marek Bolanowski
BACKGROUND: The knowledge about obesity pathogenesis is insufficient. The aim of our study was to investigate environmental and individual determinants of obesity in population of PURE study from Lower Silesia. MATERIALS AND METHODS: This was a cross sectional observation of 1064 inhabitants of Wroclaw and neighbouring rural area (671 women, 393 men), who took part in PURE study in years 2007-2010. Each participant answered PURE questionnaire and International Physical Activity Questionnaire providing information about obesity risk factors...
September 19, 2018: Endokrynologia Polska
Umit Gorkem, Zeynep Ozturk Inal, Hasan Ali Inal, Mehmet Omer Bostanci
OBJECTIVE: The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity. MATERIALS AND METHOD: A total of 171 infertile women who have fertility desire were included in this cross-sectional study. The initial assessment included the measurements of weight, height, waist circumference and hip circumference to calculate body mass index (BMI), and waist/hip ratio. All participants were categorized into two groups in accordance with BMI as a control group (< 30 kg/m2, n=135), and a study group (≥ 30 kg/m2, n=36)...
September 19, 2018: Endokrynologia Polska
Ewa Orlewska, Beata Kos-Kudła, Grzegorz Kamiński, Tadeusz Budlewski, Maria Jessa-Jabłońska, Aude Houchard, Tomasz Bednarczuk
INTRODUCTION: The primary objective of the LanroNET study was to evaluate resource utilization and cost of symptomatic treatment of patients with neuroendocrine tumors (NET) using lanreotide autogel 120 mg. MATERIAL AND METHODS: LanroNET was a multicentre, non-interventional, prospective study conducted at 12 clinical centers in Poland. Eligible patients were adults with symptomatic NET treated with lanreotide autogel 120 mg at least 3 months before enrolment. During 24-months of observation of real clinical practice, data on medical resource utilization and therapy course of patients with symptomatic NET were collected...
August 22, 2018: Endokrynologia Polska
Türkay Akbaş, İbrahim Ethem Sahin, Ayhan Ozturk
INTRODUCTION: Alterations in thyroid hormone levels occur in patients with acute neurologic disease states. The aim of this study is to study changes in thyroid hormones in patients with brain death (BD). MATERIAL AND METHODS: Eleven brain-dead patients were studied prospectively. Thyroid hormones were measured on admission to the intensive care unit, the day before BD diagnosis (BD before) and the day after BD diagnosis (BD day). RESULTS: Thyroid stimulating hormone (TSH) and free triiodothyronine (fT3) concentrations were found to be significantly low on admission, BD before and BD day compared to age-matched healthy controls...
August 22, 2018: Endokrynologia Polska
Agnieszka Baranowska-Bik, Małgorzata Kalisz, Lidia Martyńska, Ewa Wolińska-Witort, Maria Styczyńska, Małgorzata Chodakowska-Żebrowska, Maria Barcikowska, Bogusława Baranowska, Wojciech Bik
Introduction Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Typical features of AD include memory loss, social dysfunction and physical impairment. Although the pathological findings in the central nervous system are well established, the etiological factors are poorly known. Recent studies suggested the role of metabolic disturbances in the development of AD neurodegeneration. Adiponectin, an anti-inflammatory and metabolism regulating factor, was linked to AD. Aim The aim was to examine whether adiponectin fractions combined with insulin/insulin resistance-associated metabolic parameters correlate with AD progression...
August 17, 2018: Endokrynologia Polska
Andrzej Lewiński, Joanna Smyczyńska, Renata Stawerska, Maciej Hilczer, Magdalena Stasiak, Tomasz Bednarczuk, Marek Bolanowski, Roman Junik, Marek Ruchała, Anhelli Syrenicz, Mieczysław Walczak, Wojciech Zgliczyński, Małgorzata Karbownik-Lewińska
Growth hormone (GH) has been used in the treatment of short stature in children with GH deficiency (GHD) for 60 years, and for about 30 years also in the treatment of adults with GHD, in whom such treatment is carried out due to metabolic indications. In Poland, GH treatment is reimbursed only in children with GHD, while so far it has not been refunded in adults with GHD. There are two groups of adults (or adolescents after growth completion) with GHD, who require GH therapy: patients with GHD that occurred in childhood (childhood-onset GHD - CO-GHD) and patients with GHD acquired in adulthood (adulthood-onset GHD - AO-GHD)...
August 17, 2018: Endokrynologia Polska
Zoltan Herold, Marton Doleschall, Annamaria Kovesdi, Attila Patocs, Aniko Somogyi
Chromogranin A is a member of the granin glycoprotein family that is expressed by the endocrine and neuroendocrine cells of different organs. Intracellularly, Chromogranin A contributes to the regulation of secretion, and gives several cleavage products after secretion. Some of its cleavage products modify the hormone functions in autocrine and paracrine ways, while the functions of others have not been fully understood yet. Serum Chromogranin A level is most prominently used in neuroendocrine tumor diagnostics...
August 3, 2018: Endokrynologia Polska
Marlena Juszczak, Anna Krzyminska, Ewa Bojanowska, Magdalena Roszczyk
INTRODUCTION: Melatonin was found to inhibit forskolin-stimulated oxytocin (OT) and vasopressin (VP) release in vitro. The purpose of the present investigation was to evaluate the contribution of the cyclic 3',5'-adenosine monophosphate/protein kinase A (cAMP/PKA) signaling pathway in melatonin-dependent inhibition of OT and VP secretion from the rat hypothalamo-neurohypophysial (H-NH) system in vitro. MATERIAL AND METHODS: The H-NH explants were placed in 1 ml of normal Krebs-Ringer (nK-R) buffer and first preincubated for 30 min in control buffer or in the presence of PKA inhibitor, i...
August 3, 2018: Endokrynologia Polska
Borys M Kwinta, Aleksander Wilk, Małgorzata Trofimiuk-Muldner, Ewelina Grzywna, Roger M Krzyżewski, Krzysztof Stachura, Dariusz Adamek
INTRODUCTION: Cavernous sinus invasion by pituitary adenoma affects surgical procedure radicality, and consequently the postoperative course and prognosis in pituitary adenomas treatment. The search for pituitary adenoma aggressive behaviour markers is still a matter of debate. MATERIAL AND METHODS: This study evaluates the relation of pituitary adenoma invasiveness to the expression of topoisomerase IIα in 72 patients who underwent transsphenoidal pituitary surgery...
August 3, 2018: Endokrynologia Polska
Marek Pawlikowski Łódź, Maria Jaranowska, Jolanta Fryczak, Maciej Radek, Jacek Świętosławski, Jolanta Kunert-Radek, Katarzyna Winczyk
INTRODUCTION: Although the active gonadotropin-secreting pituitary adenomas are considered as very rare, the vast majority of pituitary tumours diagnosed as "nonfunctioning" express gonadotropins or their free β or α subunits. However, the systemic investigations comparing the serum concentrations of follitropin (FSH), lutropin (LH) and α-subunit (αSU) before surgery with the immunoreactivity of the respective substances in the excised tumours are still lacking. MATERIALS AND METHODS: Immunostaining of FSH, LH and αSU was compared in 43 surgically removed gonadotropin - expressing pituitary adenomas with serum concentrations of the above mentioned substances before surgery in the same patients...
August 3, 2018: Endokrynologia Polska
Dagmar Horakova, Ladislav Stepanek, Radka Nagelova, Dalibor Pastucha, Katerina Azeem, Helena Kollarova
INTRODUCTION: Adiponectin is a peptide secreted by adipocytes, whose reduction is connected with obesity-related diseases, including insulin resistance. The study analyzed levels of total adiponectin and its high molecular weight (HMW) oligomer in a group of metabolically healthy adults and in patients with type 2 diabetes mellitus (T2DM) to evaluate these levels as potential predictors of the development of insulin resistance. Material and mehods: The study comprised 269 metabolically healthy adults and 300 patients with T2DM...
June 28, 2018: Endokrynologia Polska
Ana Savic-Radojevic, Ilijana Mazibrada, Tatjana Djukic, Zoran B Stankovic, Marija Pljesa-Ercegovac, Katarina Sedlecky, Jelica Bjekic-Macut, Tatjana Simic, George Mastorakos, Djuro Macut
INTRODUCTION: It has been supposed that endocrine disturbances might be responsible for PCOS-associated oxidative stress, with special emphasis on hyperandrogenism.Considering potential relationship between hyperandrogenism and increased free radicals production, parameters of oxidative stress were determined in non-obese normoinsulinemic adolescent girls newly diagnosed with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS: Nitrotyrosine, thiol groups' concentrations, glutathione peroxidase and superoxide dismutase activities were determined under fasting conditions and during oral glucose tolerance test (OGTT) in 35 PCOS patients and 17 controls...
June 28, 2018: Endokrynologia Polska
Beata Matyjaszek-Matuszek, Aneta Szafraniec, Dominik Porada
Obesity, which affects about 13% of the world population, results in significant deterioration of health and serious clinical, mainly meta-bolic and cardiovascular complications. Although the basis of therapeutic treatment is behavioural treatment, often non-pharmacological effects do not produce the desired effect. Currently there are several drugs with a safe action profile that improve the effect of treatment (5-10% weight reduction). The aim of the paper is to present the potential of modern pharmacotherapy in the treatment of obesity, in terms of mechanism of action, efficacy, and side effects, in order to individualise therapy...
2018: Endokrynologia Polska
Katarzyna Cypryk, Piotr Małecki
Type 2 diabetes is a complex metabolic disorder associated with a high risk of cardiovascular complications. In December 2008, due to concerns about the cardiac safety of antihyperglycaemic therapies, the Food and Drug Administration (FDA) published a new guidance on special requirements for the demonstration of cardiovascular safety for these medications. In 2012, similar recommendations were made for antidiabetic drug manufacturers by the European Medicines Agency (EMA). Since then, both FDA and EMA recommendations have been applied in cardiovascular outcome trials (CVOTs) for several new antihyperglycaemic drugs...
2018: Endokrynologia Polska
Magdalena Góralska, Tomasz Bednarczuk, Marek Rosłon, Maria Libura, Mieczysław Szalecki, Maciej Hilczer, Renata Stawerska, Joanna Smyczyńska, Małgorzata Karbownik-Lewińska, Mieczysław Walczak, Andrzej Lewiński
Prader-Willi syndrome (PWS) is a complex genetic disorder characterised by a set of phenotypic traits, which include infantile hypotonia, short stature, and morbid obesity. Over the last 12 years, visible progress has been made in medical care management of PWS patients in Poland. Increasing awareness of the disorder in neonatal and paediatric care has led to early identification of the condition in neonates, followed by the institution of an appropriate dietary regime, introduction of physiotherapy, and early-onset recombinant human growth hormone (rhGH) treatment...
2018: Endokrynologia Polska
Andrzej Milewicz, Marek Kudła, Robert Z Spaczyński, Romuald Dębski, Błażej Męczekalski, Mirosław Wielgoś, Marek Ruchała, Ewa Małecka-Tendera, Beata Kos-Kudła, Diana Jędrzejuk, Agnieszka Zachurzok
Polycystic ovary syndrome (PCOS) diagnosis and therapy still arouse a lot of controversy. Each year brings new information, so, having collected the experience of three scientific societies, we present contemporary recommendations concerning PCOS diagnostics and treat-ment. In adult female diagnosis, we still use the Rotterdam criteria, which is two out of three of the follwing characteristics: a) ovulation abnormality, b) clinical or biochemical hyperandrogenism, and c) polycystic ovaries. In the case of teenagers, diagnostic criteria are as follows: menstruation disturbances two years after menarche and clinical or biochemical hyperandrogenism...
2018: Endokrynologia Polska
Marzena Dębska, Małgorzata Gietka-Czernel, Piotr Kretowicz, Dagmara Filipecka-Tyczka, Łukasz Lewczuk, Joanna Dangel, Romuald Dębski
INTRODUCTION: Foetal hypothyroidism negatively impacts somatic and neurological child development and can be the cause of serious obstetric and perinatal complications. We present a rare case of a large foetal dyshormonogenetic goitre, causing foetal neck hyperexten-sion, oesophageal compression, and cardiac high-output failure. MATERIAL AND METHODS: A foetal goitre complicated by cardiomegaly and polyhydramnios was diagnosed at 23 weeks of gestation (WG) on a routine ultrasonographic (US) assessment in a healthy nullipara...
2018: Endokrynologia Polska
Elżbieta Andrysiak-Mamos, Karol Sagan, Leszek Sagan, Elżbieta Sowińska-Przepiera, Anhelli Syrenicz
The differentiation of cystic lesions located in the sellar-suprasellar region is a significant problem in clinical practice because of the similarities in their clinical, radiological, and even histopathological picture. Arriving at the right diagnosis is vital for taking appropriate therapeutic decisions. The most frequent clinical manifestation of lesions located in the sellar-suprasellar region is headache. It often co-exists with symptoms of anterior pituitary gland insufficiency or hyperprolactinaemia caused by compression of the pituitary stalk...
2018: Endokrynologia Polska
Marek Pawlikowski Łódź
In normal conditions follicle stimulating hormone receptors (FSHR) are expressed in zona granulosa cells of the ovary and Sertoli cells of the testis. However, the ectopic expression of FSHR was recently discovered in intra-tumoral blood vessels endothelia and/or in tumoral cells of many extra-gonadal human tumors (particularly in endocrine tumours). The paper reviews the data concerning the appearance of ectopic FSHR in particular human neoplasms. The possible involvement of FSHR in tumor progression and the use of FSHR examination for diagnostic purposes is also reviewed...
2018: Endokrynologia Polska
Robert Krysiak, Agnieszka Drosdzol-Cop, Violetta Skrzypulec-Plinta, Bogusław Okopień
INTRODUCTION: No previous study has investigated sexual functioning in prediabetic women. AIM: This study was aimed at investigating sexual function in young women with various types of prediabetes. METHODS: The study included four groups of women: women with isolated impaired fasting glucose (Group A; n=19), isolated impaired glucose tolerance (Group B; n=18), presence of both impaired fasting glucose and impaired glucose tolerance (Group C; n=18), as well as matched healthy controls (Group D; n=19)...
2018: Endokrynologia Polska
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