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Endokrynologia Polska

Anna La Salvia, Maria Pia Brizzi, Leonardo Muratori, Elena Trevisi, Massimo Di Maio, Giorgio Vittorio Scagliotti
INTRODUCTION: Neuroendocrine neoplasms (NENs) are a rare and heterogeneous group of tumors, with a variety of primary origins and variable aggressiveness. NENs with an atypical primary origin, such as breast and retroperitoneal NENs, are extremely rare. As a consequence, an established diagnostic and therapeutic strategy in this particular subgroup is lacking. The combination of capecitabineandtemozolomide, called CAPTEM regimen, has produced promising response rates in patients with grade1 or 2neuroendocrine tumors of multiple origins...
October 25, 2018: Endokrynologia Polska
Beata Banaszak, Elżbieta Świętochowska, Paweł Banaszak, Katarzyna Ziora
Introduction Hypertension is regarded to be a condition of mild inflammation and endothelial imbalance. The aim of the study was to evaluate serum concentrations of biomarkers of inflammation and endothelial function: tumor necrosis factor alpha (TNF-α), endothelin-1 (ET-1) and N-terminal fragment of proatrial natriuretic peptide (NTpro-ANP) in hypertensive and normotensive children. Material and methods We studied 63 children aged 13,56 ± 3,73 years, divided into: group with primary hypertension (n=50) and group with renal hypertension (n=13)...
October 25, 2018: Endokrynologia Polska
Sandra Pekic, Vladimir Jovanovic, Goran Tasic, Ivan Paunovic, Svetislav Tatic, Dusko Dundjerovic, Mirjana Doknic, Dragana Miljic, Marko Stojanovic, Marina Nikolic Djurovic, Milan Petakov, Vera Popovic
Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young, with only few cases reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He had a six months history of paroxysmal headache, palpitations and sweating. During examination he became somnolent and developed left-sided hemiplegia. A computed tomographic (CT) scan of the brain showed a right temporoparietal hematoma...
October 23, 2018: Endokrynologia Polska
Elżbieta Petriczko, Tomasz Jackowski, Anita Horodnicka-Józwa, Beata Wikiera, Anna Noczyńska, Maria Korpal-Szczyrska, Dorota Birkholz-Walerzak, Ewa Małecka-Tendera, Barbara Kalina-Fraska, Maria Kalina, Ewa Barg, Iwona Beń-Skowronek, Leszek Szewczyk, Maciej Hilczer, Joanna Smyczyńska, Renata Stawerska, Andrzej Lewiński, Katarzyna Ziora, Artur Bossowski, Edyta Pietrewicz, Beata Pyrżak, Andrzej Kędzia, Mieczysław Szalecki, Agnieszka Kilian, Mieczysław Walczak
INTRODUCTION: The objective of this study was to analyze the effects of the first three years of treatment with recombinant human insulin-like growth factor 1 (rhIGF-1) in patients from the Polish population. MATERIAL AND METHODS: Twenty-seven children (22 boys and 5 girls) aged 2.8 to 16.0 years old were qualified for treatment with rhIGF-1 (mecasermin) in different treatment centers, according to Polish criteria: body height below -3.0 SD and IGF-1 concentration below 2...
October 23, 2018: Endokrynologia Polska
Robert Krysiak, Bogdan Marek, Bogusław Okopień
INTRODUCTION: Although hyperthyroidism is characterized by female predominance, its presence may lead to the development of numerous complications in both sexes. This study was aimed at investigating sexual function and depressive symptoms in men with overt hyperthyroidism of autoimmune and non-autoimmune origin. MATERIAL AND METHODS: The study population consisted of three age-matched groups: men with overt hyperthyroidism and Graves' disease (group A; n=20), men with overt hyperthyroidism and toxic multinodular goiter or toxic adenoma (group B; n=21) and men with normal thyroid function (group C; n=23)...
October 11, 2018: Endokrynologia Polska
Adam Maciejewski, Rafał Czepczyński, Marek Ruchała
Patients affected by differentiated thyroid cancer are treated surgically and by ablative radioiodine therapy. Post-therapy whole body scan allows detecting thyroid remnants or local and distant metastases, although false-positive findings may be observed. We report a case of 75-year-old woman with follicular thyroid cancer, who underwent ablative radioiodine treatment. On post-therapy whole body scan, abnormal uptake in the left upper abdomen was found, although stimulated thyroglobulin level was not suggestive for distant metastases of differentiated thyroid carcinoma...
October 11, 2018: Endokrynologia Polska
Wojciech Gilowski, Robert Krysiak, Bogdan Marek, Bogusław Okopień
INTRODUCTION: Both angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers were found to reduce plasma levels of proinflammatory cytokines. No previous study has compared their effect on production of anti-inflammatory cytokines. MATERIAL AND METHODS: The study enrolled 52 patients with grade 1 and grade 2 arterial hypertension. The participants were divided into two groups treated with either perindopril (4 mg daily) or telmisatran (40 mg daily)...
September 27, 2018: Endokrynologia Polska
Barbara Grzechocinska, Filip Andrzej Dabrowski, Janusz Sierdzinski, Anna Cyganek, Miroslaw Wielgos
OBJECTIVE: Increased levels and activity of some MMPs are described in obesity-related vascular diseases. Factors that influence MMPs blood concentration are still investigated. This research aim to evaluate the concentration of most types of MMPs: collagenases (MMP-1,-3,-8,-13), matrilisine (MMP-7), gelatinase (MMP-9) and malloelsastase (MMP-12) in serum of women in reproductive age in relation with their body mass index (BMI), age, estradiol and progesterone concentrations. METHODS: Blood samples were taken from 54 healthy premenopausal women with normal menstrual cycles...
September 27, 2018: Endokrynologia Polska
Hande Peynirci, Bengür Taskiran, Nagehan Dik, Ozlem Saraydaroglu, Canan Ersoy
INTRODUCTION: Oncocytomas arising in adrenal glands are extremely rare and usually detected incidentally. Herein, we aimed to present clinical, radiological, pathological and immunohistochemical staining aspects of 11 patients diagnosed as adrenal oncocytomas and review the literature. MATERIAL AND METHODS: Patients' age, gender, symptoms suggesting hormonal activity, other illnesses, biochemical and endocrinological assessment, mass characteristics, pathological diagnosis and their follow-up periods from the date of surgery were recorded from their files who applied to internal medicine and endocrinology and metabolism outpatient clinics of Uludağ University Medical Faculty between January 2005 and November 2016...
September 27, 2018: Endokrynologia Polska
Piotr Kmieć, Ilona Minkiewicz, Krzysztof Sworczak, Michał A Żmijewski, Konrad Kowalski
INTRODUCTION: In the context of pleiotropic vitamin D effects its role has also been investigated in thyroid pathology, in particular autoimmune thyroid diseases (AITD). However, available data concerning vitamin D status among Polish adult population are inconclusive. AIM: In the study we investigated vitamin D status and adequacy of supplementation, as well as sunlight exposure during summer months among adult patients with thyroid diseases. MATERIALS AND METHODS: Adults with diagnosed or suspected thyroid disease were recruited almost entirely in an ambulatory setting from June through September in Northern Poland...
September 27, 2018: Endokrynologia Polska
Jovana Komazec, Vera Zdravkovic, Silvija Sajic, Maja Jesic, Marina Andjelkovic, Sonja Pavlovic, Milena Ugrin
INTRODUCTION: Maturity onset diabetes of the young (MODY) is a rare form of monogenic diabetes. Being clinically and genetically heterogeneous, it is often misdiagnosed as type 1 or type 2 diabetes, leading to inappropriate therapy. MODY is caused by a single gene mutation. Thirteen genes, defining 13 subtypes, have been identified to cause MODY. A correct diagnosis is important for the right therapy, prognosis and genetic counseling. MATERIALS AND METHODS: Twenty nine unrelated pediatric patients clinically suspected to have MODY diabetes were analyzed using TruSight One panel for next generation sequencing (NGS) and multiplex ligation-dependent probe amplification (MLPA) assay...
September 27, 2018: Endokrynologia Polska
Katarzyna Pasternak-Pietrzak, Constantine A Stratakis, Elżbieta Moszczyńska, Agnieszka Lecka-Ambroziak, Michał Staniszewski, Urszula Wątrobińska, Charalampos Lyssikatos, Monika Prokop-Piotrkowska, Wiesława Grajkowska, Maciej Pronicki, Mieczysław Szalecki
INTRODUCTION: Primary pigmented nodular adrenocortical disease (PPNAD) is a rare form of ACTH-independent Cushing's syndrome (CS). Half of patients with PPNAD are sporadic cases and the other half familial. MATERIAL AND METHODS: We present 2 patients with PPNAD confirmed by genetic analysis. RESULTS: In both patients there were no abnormal findings on diagnostic imaging of both adrenals and heart. Patients underwent bilateral two-stage adrenalectomy...
September 27, 2018: Endokrynologia Polska
Robert Krysiak, Agnieszka Barbara Drosdzol-Cop, Violetta Skrzypulec-Plinta, Bogusław Okopień
INTRODUCTION: Statins were found to improve erectile function in men. No previous study has investigated prospectively sexual functioning in women receiving these agents. AIM: The aim of this study was to evaluate the impact of atorvastatin therapy on female sexual functions and depressive symptoms in young women with elevated cholesterol levels. METHODS: The study included 14 women with elevated cholesterol levels and 14 matched women with normal plasma lipids...
September 27, 2018: Endokrynologia Polska
Aleksandra Zdrojowy-Wełna, Katarzyna Zatońska, Grażyna Bednarek-Tupikowska, Alicja Jokiel-Rokita, Katarzyna Kolackov, Andrzej Szuba, Marek Bolanowski
BACKGROUND: The knowledge about obesity pathogenesis is insufficient. The aim of our study was to investigate environmental and individual determinants of obesity in population of PURE study from Lower Silesia. MATERIALS AND METHODS: This was a cross sectional observation of 1064 inhabitants of Wroclaw and neighbouring rural area (671 women, 393 men), who took part in PURE study in years 2007-2010. Each participant answered PURE questionnaire and International Physical Activity Questionnaire providing information about obesity risk factors...
September 19, 2018: Endokrynologia Polska
Umit Gorkem, Zeynep Ozturk Inal, Hasan Ali Inal, Mehmet Omer Bostanci
OBJECTIVE: The aim of the present study was to investigate the changes in serum progranulin and sex hormone levels in infertile women with obesity. MATERIALS AND METHOD: A total of 171 infertile women who have fertility desire were included in this cross-sectional study. The initial assessment included the measurements of weight, height, waist circumference and hip circumference to calculate body mass index (BMI), and waist/hip ratio. All participants were categorized into two groups in accordance with BMI as a control group (< 30 kg/m2, n=135), and a study group (≥ 30 kg/m2, n=36)...
September 19, 2018: Endokrynologia Polska
Ewa Orlewska, Beata Kos-Kudła, Grzegorz Kamiński, Tadeusz Budlewski, Maria Jessa-Jabłońska, Aude Houchard, Tomasz Bednarczuk
INTRODUCTION: The primary objective of the LanroNET study was to evaluate resource utilization and cost of symptomatic treatment of patients with neuroendocrine tumors (NET) using lanreotide autogel 120 mg. MATERIAL AND METHODS: LanroNET was a multicentre, non-interventional, prospective study conducted at 12 clinical centers in Poland. Eligible patients were adults with symptomatic NET treated with lanreotide autogel 120 mg at least 3 months before enrolment. During 24-months of observation of real clinical practice, data on medical resource utilization and therapy course of patients with symptomatic NET were collected...
August 22, 2018: Endokrynologia Polska
Türkay Akbaş, İbrahim Ethem Sahin, Ayhan Ozturk
INTRODUCTION: Alterations in thyroid hormone levels occur in patients with acute neurologic disease states. The aim of this study is to study changes in thyroid hormones in patients with brain death (BD). MATERIAL AND METHODS: Eleven brain-dead patients were studied prospectively. Thyroid hormones were measured on admission to the intensive care unit, the day before BD diagnosis (BD before) and the day after BD diagnosis (BD day). RESULTS: Thyroid stimulating hormone (TSH) and free triiodothyronine (fT3) concentrations were found to be significantly low on admission, BD before and BD day compared to age-matched healthy controls...
August 22, 2018: Endokrynologia Polska
Agnieszka Baranowska-Bik, Małgorzata Kalisz, Lidia Martyńska, Ewa Wolińska-Witort, Maria Styczyńska, Małgorzata Chodakowska-Żebrowska, Maria Barcikowska, Bogusława Baranowska, Wojciech Bik
Introduction Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Typical features of AD include memory loss, social dysfunction and physical impairment. Although the pathological findings in the central nervous system are well established, the etiological factors are poorly known. Recent studies suggested the role of metabolic disturbances in the development of AD neurodegeneration. Adiponectin, an anti-inflammatory and metabolism regulating factor, was linked to AD. Aim The aim was to examine whether adiponectin fractions combined with insulin/insulin resistance-associated metabolic parameters correlate with AD progression...
August 17, 2018: Endokrynologia Polska
Andrzej Lewiński, Joanna Smyczyńska, Renata Stawerska, Maciej Hilczer, Magdalena Stasiak, Tomasz Bednarczuk, Marek Bolanowski, Roman Junik, Marek Ruchała, Anhelli Syrenicz, Mieczysław Walczak, Wojciech Zgliczyński, Małgorzata Karbownik-Lewińska
Growth hormone (GH) has been used in the treatment of short stature in children with GH deficiency (GHD) for 60 years, and for about 30 years also in the treatment of adults with GHD, in whom such treatment is carried out due to metabolic indications. In Poland, GH treatment is reimbursed only in children with GHD, while so far it has not been refunded in adults with GHD. There are two groups of adults (or adolescents after growth completion) with GHD, who require GH therapy: patients with GHD that occurred in childhood (childhood-onset GHD - CO-GHD) and patients with GHD acquired in adulthood (adulthood-onset GHD - AO-GHD)...
August 17, 2018: Endokrynologia Polska
Zoltan Herold, Marton Doleschall, Annamaria Kovesdi, Attila Patocs, Aniko Somogyi
Chromogranin A is a member of the granin glycoprotein family that is expressed by the endocrine and neuroendocrine cells of different organs. Intracellularly, Chromogranin A contributes to the regulation of secretion, and gives several cleavage products after secretion. Some of its cleavage products modify the hormone functions in autocrine and paracrine ways, while the functions of others have not been fully understood yet. Serum Chromogranin A level is most prominently used in neuroendocrine tumor diagnostics...
August 3, 2018: Endokrynologia Polska
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