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Journals Documenta Ophthalmologica. Adv...

Documenta Ophthalmologica. Advances in Ophthalmology

https://read.qxmd.com/read/37775645/restoration-of-vision-by-combined-experimental-antithymocyte-therapy-and-orbital-radiation-with-high-dose-steroids-for-severe-acute-steroid-refractory-congestive-thyroid-orbitopathy
#21
JOURNAL ARTICLE
Monika Sarnat-Kucharczyk, Dorota Pojda-Wilczek, Maria Świerkot, Grażyna Kulawik, Ewa Mrukwa-Kominek
PURPOSE: We report diagnostic and therapeutic dilemmas in the difficult case of compressive optic neuropathy with severe visual acuity and visual field loss with subsequent visual recovery in both eyes, in a patient with Graves' orbitopathy (GO) by a combination of experimental antithymocyte therapy, orbital radiotherapy with high-dose steroids. METHODS: A 72-year-old man presented with severe vision loss in both eyes. The visual symptoms had appeared over a year before the GO diagnosis...
September 29, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37749441/objective-detection-of-visual-field-defects-with-multifrequency-veps
#22
JOURNAL ARTICLE
Katja Crux, Cord Huchzermeyer, Jan Kremers, Folkert K Horn
PURPOSE: To correlate multifrequency pattern reversal VEPs in quadrants (QmfrVEPs) with perimetric field losses for objective detection of visual field losses. METHODS: QmfrVEP measurements were performed using four LED-based checkerboard stimulators to stimulate the four quadrants of the visual field. QmfrVEPs were measured monocularly in 5 normal subjects and in 5 glaucoma patients who showed losses in conventional Octopus perimetry. The pattern reversal frequency varied slightly between the stimulators: (11...
September 26, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37715919/leber-congenital-amaurosis-as-the-initial-and-essential-manifestation-in-a-chinese-patient-with-autoimmune-polyglandular-syndrome-type-1
#23
JOURNAL ARTICLE
Xing Wei, Tian Zhu, Lei Wang, Ruifang Sui
PURPOSE: Autoimmune polyglandular syndrome Type 1 (APS-1) is a rare autosomal recessive disorder caused by defects in the autoimmune regulator (AIRE) gene. Patients are generally diagnosed at ages between five and fifteen years when they exhibit three or more manifestations, most typically mucocutaneous candidiasis, autoimmune Addison's disease, and hypoparathyroidism. Our study aims to report the first case of a Chinese APS-1 patient, presented with LCA as the initial and essential clinical feature of this rare syndrome...
September 16, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37668859/bilateral-macular-hole-in-a-patient-with-capn5-related-neovascular-inflammatory-vitreoretinopathy
#24
JOURNAL ARTICLE
Yong Je Choi, Se Joon Woo, Kwangsic Joo
PURPOSE: To characterize the genotype and phenotype of a patient with CAPN5-related neovascular inflammatory vitreoretinopathy (NIV) who have undergone surgery for macular holes. METHODS: We observed a patient presenting with retinitis pigmentosa and posterior uveitis who later developed vitreoretinal macular traction and a macular hole. Genetic testing was performed using a targeted gene panel. Fundus photography and spectral-domain optical coherence tomography were also performed...
September 5, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37642804/an-early-onset-cone-dystrophy-due-to-cep290-mutation-a-case-report
#25
JOURNAL ARTICLE
Anastasia Binder, Susanne Kohl, Ute Grasshoff, Karin Schäferhoff, Katarina Stingl
PURPOSE: Biallelic mutations in the CEP290 gene cause early onset retinal dystrophy or syndromic disease such as Senior-Loken or Joubert syndrome. Here, we present an unusual non-syndromic case of a juvenile retinal dystrophy caused by biallelic CEP290 mutations imitating initially the phenotype of achromatopsia or slowly progressing cone dystrophy. METHODS: We present 13 years of follow-up of a female patient who presented first with symptoms and findings typical for achromatopsia...
August 29, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37639171/diffuse-retinal-dysfunction-following-immune-reconstitution-uveitis-in-patients-with-prior-cytomegalovirus-retinitis-a-novel-observation
#26
JOURNAL ARTICLE
Yew Sen Yuen, Graham E Holder, Gopal Lingam, Tina Yu Ting Shen
PURPOSE: To report continuing diffuse retinal dysfunction following resolution of immune reconstitution uveitis (IRU) in patients with cytomegalovirus retinitis (CMVR). METHODS: Retrospective case series describing two patients with IRU following CMVR who underwent serial fundus photography and macular optical coherence tomography. One patient had serial electrophysiology. RESULTS: Both patients had CMVR successfully treated with antiviral medication...
August 28, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37639170/pattern-visual-evoked-potential-and-foveal-sensitivity-in-amblyopia
#27
JOURNAL ARTICLE
Manisha Dahal, Hira Nath Dahal, Pragati Gautam, Jyoti Baba Shrestha, Safal Khanal
PURPOSE: Amblyopic eyes show impaired visual functions such as poor visual acuity and reduced foveal sensitivity. The purpose of this study was to determine the association between foveal threshold and visual evoked potentials (VEP) in strabismic and anisometropic amblyopia. METHODS: Forty-five subjects (age range: 7-28 years, 43.3% female) including 15 strabismic and 15 anisometropic amblyopes, and 15 age-similar control subjects participated in this study...
August 28, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37530953/full-field-electroretinogram-recorded-with-skin-electrodes-in-6-to-12-year-old-children
#28
JOURNAL ARTICLE
Jiajun Wang, Yalan Wang, Weichen Guan, Yun-E Zhao
PURPOSE: To determine the full-field electroretinogram (ffERG) parameters, including the light-adapted (LA) 3 ERG and the photopic negative response (PhNR), in 6- to 12-year-old children. METHODS: ffERG data were obtained from 214 eyes of 214 healthy subjects. The amplitudes and peak time of the ffERG responses were obtained from children divided into 6- to 8-year-old and 9- to 12-year-old groups. Using a skin electrode, electrical signals were measured in response to white stimulating light and white background light (LA 3 ERG)...
August 2, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/36881212/pediatric-abusive-head-trauma-visual-outcomes-evoked-potentials-diffusion-tensor-imaging-and-relationships-to-retinal-hemorrhages
#29
JOURNAL ARTICLE
John P Kelly, Kenneth W Feldman, Jason N Wright, James B Metz, Avery Weiss
PURPOSE: Function and anatomy of the visual system were evaluated in children with abusive head trauma (AHT). The relationships between retinal hemorrhages at presentation were examined with outcome measures. METHODS: Retrospective review of data in children with AHT for 1) visual acuity at last follow-up, 2) visual evoked potentials (VEP) after recovery, 3) diffusion metrics of white matter tracts and grey matter within the occipital lobe on diffusion tensor imaging (DTI), and 4) patterns of retinal hemorrhages at presentation...
August 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37515709/retinal-dysfunction-in-parkinson-s-disease-results-of-the-extended-protocol-for-photopic-negative-response-phnr-full-field-electroretinogram-erg
#30
JOURNAL ARTICLE
Osman Ahmet Polat, Murat Gultekin, Hidayet Sener, Furkan Ozer, Hatice Arda
BACKGROUND: We investigated whether the photopic negative response (PhNR) in the electroretinogram (ERG) was affected in Parkinson's disease (PD) patients and whether it was associated with retinal changes on optical coherence tomography (OCT). METHODS: Thirty-two patients with PD and 31 age and sex-matched healthy controls from a single tertiary centre were included in the study. Hoehn and Yahr scale scores and the presence of REM sleep behaviour were recorded...
July 29, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37460904/fundus-autofluorescence-optical-coherence-tomography-and-electroretinography-abnormalities-in-a-patient-with-digoxin-retinopathy-that-resemble-those-in-kcnv2-associated-retinopathy
#31
JOURNAL ARTICLE
Yuki Nagae, Kazuki Kuniyoshi, Marika Ishibashi, Fumi Tanabe, Chota Matsumoto, Shunji Kusaka
BACKGROUND: Digoxin related retinal toxicity causes blurred vision, photophobia, central scotoma, color vision abnormality, and electroretinography (ERG) abnormalities. Here, we report a case with transient abnormalities in vison, in which fundus autofluorescence (FAF), optical coherence tomography (OCT), and ERG findings resembled those in KCNV2 (potassium voltage-gated channel modifier subfamily V member 2)-associated retinopathy. CASE REPORT: An 89-year-old woman presented with complaints of acute blurred vision, nyctalopia, photophobia, and color vision abnormality...
July 17, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37392267/electrophysiological-findings-in-extensive-macular-atrophy-with-pseudodrusen
#32
JOURNAL ARTICLE
Sung Eun Song Watanabe, Andressa Zanini Fantato Quercia, Paula Yuri Sacai
PURPOSE: To present electroretinogram findings in extensive macular atrophy with pseudodrusen (EMAP) and describe associated systemic factors. DESIGN: Retrospective case series. METHODS: Data on medical history, visual symptoms, multimodal imaging findings, and visual field were collected from the medical records of patients with extensive macular atrophy with pseudodrusen who attended a visual electrophysiology laboratory. Electrophysiological tests, including full-field electroretinogram, multifocal electroretinogram and photopic negative response, were performed...
July 1, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37369909/intravitreal-acetazolamide-implant-for-pseudophakic-cystoid-macular-edema
#33
JOURNAL ARTICLE
Rodrigo Jorge, Isabela Franco Villela, Christian Fernandes, Thais Marino de Azevedo Bastos, Ingrid U Scott, Armando da Silva Cunha, Silvia Ligório Fialho, Pedro Henrique Reis da Silva, André Messias
BACKGROUND: Pseudophakic cystoid macular edema (PCME) is the most common cause of visual acuity deterioration after uncomplicated cataract surgery. There is no consensus regarding how to manage recurrent or refractory cases. REPORT: A 54-year-old woman complained of decreased vision and central metamorphopsia in the right eye (OD) 3 months after uneventful cataract surgery. Visual acuity was 0.3 logMAR (20/40) OD and 0.1 logMAR (20/25) OS. Reduced macular brightness was seen OD on funduscopy associated with increased macular thickness on optical coherence tomography (OCT)...
June 28, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37302110/age-associated-changes-in-electroretinography-measures-in-companion-dogs
#34
JOURNAL ARTICLE
Michele M Salzman, Natascha Merten, Wojciech K Panek, Gilad Fefer, Alejandra Mondino, Hans D Westermeyer, Margaret E Gruen, Natasha J Olby, Freya M Mowat
PURPOSE: To determine the association between age and retinal full-field electroretinographic (ERG) measures in companion (pet) dogs, an important translational model species for human neurologic aging. METHODS: Healthy adult dogs with no significant ophthalmic abnormalities were included. Unilateral full-field light- and dark-adapted electroretinography was performed using a handheld device, with mydriasis and topical anaesthesia. Partial least squares effect screening analysis was performed to determine the effect of age, sex, body weight and use of anxiolytic medication on log-transformed ERG peak times and amplitudes; age and anxiolytic usage had significant effects on multiple ERG outcomes...
June 11, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37269394/iscev-guidelines-for-calibration-and-verification-of-stimuli-and-recording-instruments-2023-update
#35
JOURNAL ARTICLE
Daphne L McCulloch, Michael Bach, Mitchell Brigell, Hoover Chan, Ruth Hamilton, Chris Hogg, J Vernon Odom, Anthony G Robson
This document developed by the International Society for Clinical Electrophysiology of Vision (ISCEV) provides guidance for calibration and verification of stimulus and recording systems specific to clinical electrophysiology of vision. This guideline provides additional information for those using ISCEV Standards and Extended protocols and supersedes earlier Guidelines. The ISCEV guidelines for calibration and verification of stimuli and recording instruments (2023 update) were approved by the ISCEV Board of Directors 01, March 2023...
June 3, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/36702946/frequency-domain-analysis-of-transient-visual-evoked-potentials-in-schizophrenia
#36
JOURNAL ARTICLE
Yu-Ting Tsai, James Gordon, Pamela Butler, Vance Zemon
PURPOSE: Frequency-domain measures were applied to characterize neural deficits in individuals with schizophrenia using transient visual evoked potentials (tVEP). These measures were compared with conventional time-domain measures to elucidate underlying neurophysiological mechanisms and examine the value of frequency analysis. METHODS: Four frequency bands of activity identified in previous work were explored with respect to magnitude (spectral power), timing (phase), a combined measure, magnitude-squared coherence (MSC), and compared to amplitudes and times of prominent deflections in the response...
June 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37233898/analysis-of-the-slope-between-p50-and-n95-waves-of-the-large-field-pattern-electroretinogram-as-an-additional-indicator-of-ganglion-cell-dysfunction
#37
JOURNAL ARTICLE
Maja Sustar Habjan, Jelka Brecelj, Marko Hawlina
AIM: Dysfunction of the retinal ganglion cells (RGC) can be detected by the pattern electroretinogram (PERG) as a reduction of the N95 amplitude, a decrease of the ratio between N95 and P50 amplitude and/or a shortening of P50 peak time. Additionally, the slope from the top of the P50 towards the N95 (P50-N95 slope) is less steep than in control subjects. The aim of the study was to quantitatively evaluate this slope in large field PERGs in controls and patients with RGC dysfunction due to optic neuropathy...
May 26, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37227616/a-mild-form-of-poc1b-associated-retinal-dystrophy-with-relatively-preserved-cone-system-function
#38
JOURNAL ARTICLE
Takaaki Hayashi, Kei Mizobuchi, Shuhei Kameya, Shinji Ueno, Tomokazu Matsuura, Tadashi Nakano
PURPOSE: Biallelic variants in POC1B are rare causes of autosomal recessive cone dystrophy associated with generalized cone system dysfunction. In this report, we describe the clinical characteristics of a Japanese male patient with POC1B-associated retinopathy with relatively preserved cone system function. METHODS: We performed whole-exome sequencing (WES) to identify the disease-causing variants and a comprehensive ophthalmic examination, including full-field and multifocal electroretinography (ffERG and mfERG)...
May 25, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37219642/evaluation-of-correlation-between-diopsys%C3%A2-%C3%A2-nova%C3%A2-fixed-luminance-flicker-erg-and-diagnosys%C3%A2-%C3%A2-espion-2%C3%A2-flicker-erg-parameters
#39
JOURNAL ARTICLE
Jonathan Regenold, Hien Luong Doan, Hashem Ghoraba, Hassan Khojasteh, Jaclyn Joyce Jaclyn Hwang, Negin Yavari, Amir Akhavanrezayat, Ngoc Trong Tuong Than, Anthony Huy Dinh Le, Muhammad Sohail Halim, Quan Dong Nguyen
PURPOSE: Diopsys® NOVA™ is a novel full-field electroretinography (ffERG) device that can make rapid measurements of retinal electrophysiologic function. Diagnosys® Espion 2™ is a clinical gold-standard ERG device. This study aimed to investigate whether light-adapted Diopsys® NOVA™ fixed-luminance flicker ffERG magnitude and implicit time (converted from phase) measurements correlate with light-adapted Diagnosys® Espion 2™ flicker ffERG amplitude and implicit time measurements, respectively...
May 23, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37162688/electroretinographic-abnormalities-in-alport-syndrome-with-a-novel-col4a5-truncated-variant-p-try20glyfster19
#40
JOURNAL ARTICLE
Kei Mizobuchi, Takaaki Hayashi, Ryo Ohira, Tadashi Nakano
PURPOSE: Alport syndrome comprises a heterogeneous group of inherited kidney diseases that are associated with ocular complications. In this study, we aimed to detail the clinical characteristics of a patient with X-linked Alport syndrome. METHODS: We performed next-generation sequencing (NGS) with hybridization capture to identify the disease-causing variant of Alport syndrome and a comprehensive ophthalmic examination, including full-field electroretinography (FF-ERG)...
May 10, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
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