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Journals Documenta Ophthalmologica. Adv...

Documenta Ophthalmologica. Advances in Ophthalmology

https://read.qxmd.com/read/38498077/morphological-and-functional-correlations-in-acute-central-serous-chorioretinopathy
#1
JOURNAL ARTICLE
Peter Kiraly, Maja Šuštar Habjan, Jaka Smrekar, Polona Jaki Mekjavić
PURPOSE: We evaluate morphological and functional correlations in patients with acute central serous chorioretinopathy (CSC). METHODS: A prospective study was conducted on 50 patients with an acute CSC episode lasting less than 3 months. At baseline, assessments included optical coherence tomography (OCT), best-corrected visual acuity (BCVA), contrast sensitivity (CS), microperimetry (MP), and multifocal electroretinography (mfERG). A correlation analysis between OCT morphological parameters (maximal subretinal fluid height (SRF), central retinal thickness (CRT), and macular volume (MV)) and functional parameters was conducted on the affected eye for each patient...
March 18, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38488946/iscev-standard-for-clinical-pattern-electroretinography-2024-update
#2
JOURNAL ARTICLE
D A Thompson, M Bach, J J McAnany, M Šuštar Habjan, S Viswanathan, A G Robson
The pattern electroretinogram (PERG) is a localized retinal response evoked by a contrast-reversing pattern, usually a black and white checkerboard, which provides information about macular and retinal ganglion cell function. This document, from the International Society for Clinical Electrophysiology of Vision (ISCEV; www.iscev.org ) presents an updated and revised Standard for clinical PERG testing. This replaces the 2013 and all earlier versions. Minimum protocols for basic PERG stimuli, recording methods and reporting are specified, to promote consistency of methods for diagnosis and monitoring purposes, while responding to evolving clinical practices and technology...
March 15, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38451375/electroretinographic-oscillatory-potentials-in-leber-hereditary-optic-neuropathy
#3
JOURNAL ARTICLE
Mirella T S Barboni, Maja Sustar Habjan, Sanja Petrovic Pajic, Marko Hawlina
PURPOSE: Leber hereditary optic neuropathy (LHON) affects retinal ganglion cells causing severe vision loss. Pattern electroretinogram and photopic negative response (PhNR) of the light-adapted (LA) full-field electroretinogram (ERG) are typically affected in LHON. In the present study, we evaluated dark-adapted (DA) and LA oscillatory potentials (OPs) of the flash ERG in genetically characterized LHON patients to dissociate slow from fast components of the response. METHODS: Seven adult patients (mean age = 28...
March 7, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38416305/effect-of-eccentric-fixation-on-the-steady-state-pattern-electroretinogram
#4
JOURNAL ARTICLE
Evelyn B N Friedel, Julia Haldina, Kathrin Nickel, Michael Bach, Ludger Tebartz van Elst, Sven P Heinrich
PURPOSE: The steady-state pattern electroretinogram (ssPERG) is used to assess retinal ganglion cell function in a variety of research contexts and diagnostic applications. In certain groups of patients or study participants, stable central fixation of the stimulus is not guaranteed. The present study aimed at assessing the effects of misfixation on the ssPERG response to checkerboard reversal stimuli. METHODS: Using two check sizes (0.8° and 15°), we compared ssPERG responses for several amounts of fixation deviation, ranging from 0° to 19° horizontally and from 0° to 14° diagonally...
February 28, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38363513/autoimmune-retinopathy-in-a-patient-with-smoldering-multiple-myeloma-a-case-report
#5
JOURNAL ARTICLE
Zachary Bergman, Taariq Mohammed, Lisa Schocket, Rachid Aouchiche, Mary A Johnson
PURPOSE: Multiple myeloma (MM) is a plasma cell dyscrasia leading to proliferation of monoclonal plasma cells. Ocular involvement in multiple myeloma is uncommon but can occur. The ocular manifestations of MM may include the cornea, uvea, and retinal vasculature. We present a rare case of autoimmune retinopathy associated with smoldering MM. CASE: A 76-year-old female with no significant past medical or ocular history presented with four months of worsening vision, difficulty with night driving, and loss of peripheral vision...
February 16, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38353842/the-ips-and-iscev-joint-guidelines-for-full-field-stimulus-testing
#6
EDITORIAL
J K Jolly, C Matsumoto, R Hamilton
No abstract text is available yet for this article.
February 14, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38351363/videoocular-assessment-of-eye-movement-activity-in-an-ataxia-telangiectasia-a-case-study
#7
JOURNAL ARTICLE
Sofia A Mironets, Marina A Shurupova, Alexander F Karelin
PURPOSE: Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by progressive neurological deficits, including prominent oculomotor dysfunction. We report 5 cases of eye movement assessment in children 9-15 years old with A-T. METHODS: Three different oculomotor tasks (gaze holding, visually guided saccades and visual search) were used, and video-oculography was performed. Additionally, the scale for the assessment and rating of ataxia (SARA) score was used to assess severity of the cerebellar ataxia...
February 14, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38265517/case-of-persistent-corneal-epithelial-damage-after-cataract-surgery-leading-to-diagnosis-of-vitamin-a-deficiency
#8
JOURNAL ARTICLE
Fuyuki Yamada, Kumiko Kato, Ryunosuke Nagashima, Yuka Yonekawa, Yuzen Kashima, Mineo Kondo
PURPOSE: To report our findings of reduced full-field electroretinograms (ff-ERGs) and abnormal optical coherence tomographic (OCT) images in a patient with poor visual acuity after cataract surgery who was eventually diagnosed with vitamin A deficiency (VAD). METHODS: This was a clinical study of a patient who complained of blurred vision after cataract surgery. To determine the cause of the reduced vision, we recorded full-field electroretinograms (ff-ERGs) to determine the scotopic and photopic status of the retina...
January 24, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38243039/sensitivity-and-specificity-of-the-uniform-field-electroretinogram-in-glaucoma-detection-in-comparison-to-the-pattern-electroretinogram
#9
JOURNAL ARTICLE
Asma Hermas, Catherine Tsilfidis, Rustum Karanjia, Garfield Miller, Ange-Lynca Kantungane, Amanda El-Salibi, Irfan N Kherani, Shveta Bali, Stuart Coupland
PURPOSE: To determine the ability of the photopic negative response (PhNR) of the uniform field electroretinogram (UF-ERG) to identify early glaucomatous changes in comparison to the checkerboard and bar stimuli of the pattern electroretinogram (PERG). METHODS: Forty-nine glaucoma patients were classified into two groups: glaucoma-suspect (23 eyes) and early to moderate glaucoma (30 eyes), based on their clinical examination and the results of standard automated perimetry...
January 20, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38238632/iscev-and-ips-guideline-for-the-full-field-stimulus-test-fst
#10
JOURNAL ARTICLE
J K Jolly, J R Grigg, A M McKendrick, K Fujinami, A V Cideciyan, D A Thompson, C Matsumoto, R Asaoka, C Johnson, M W Dul, P H Artes, A G Robson
The full-field stimulus test (FST) is a psychophysical technique designed for the measurement of visual function in low vision. The method involves the use of a ganzfeld stimulator, as used in routine full-field electroretinography, to deliver full-field flashes of light. This guideline was developed jointly by the International Society for Clinical Electrophysiology of Vision (ISCEV) and Imaging and Perimetry Society (IPS) in order to provide technical information, promote consistency of testing and reporting, and encourage convergence of methods for FST...
January 18, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38206458/unusual-oct-findings-in-a-patient-with-cabp4-associated-cone-rod-synaptic-disorder
#11
JOURNAL ARTICLE
Jit Kai Tan, Gavin Arno, Dragana Josifova, Moin D Mohamed, Omar A Mahroo
PURPOSE: Bi-allelic variants in CABP4 are associated with congenital cone-rod synaptic disorder, which has also been classified, electrophysiologically, as incomplete congenital stationary night blindness (iCSNB). We describe clinical findings in a patient who demonstrated an unusual macular optical coherence tomography (OCT) phenotype, not previously reported in this condition. METHODS: Our patient underwent multimodal retinal imaging, international standard full-field ERG testing and whole genome sequencing...
January 11, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38172268/genetic-morphological-and-electrophysiological-findings-in-a-patient-with-a-rare-pathogenic-variant-in-the-rs1-gene
#12
JOURNAL ARTICLE
Lorrana Souza Azevedo, Márcio Augusto Moraes Alvarez, Gabriel Izan Santos Botelho, Alexandre Antônio Marques Rosa, Givago Silva Souza
PURPOSE: In this study, we report a case of a young adult with X-linked juvenile retinoschisis (XLRS) with a rare pathogenic variant in the RS1 gene (c.522 + 2 T > A). METHODS: Ophthalmological evaluation, optical coherence tomography, full-field and multifocal electroretinograms and extensive genetic screening of genes related to visual loss were carried out in the participant. RESULTS: Clinical ophthalmological exams revealed a mild to moderate impairment of visual acuity...
January 3, 2024: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/38129706/an-incipient-late-onset-retinal-degeneration-with-a-c1qtnf5-mutation-a-case-report-with-an-11-year-follow-up
#13
JOURNAL ARTICLE
Nuria Torrell-Belzach, Alexandra Miere, Rakia Bhouri, Mayer Srour, Eric H Souied, Olivia Zambrowski
PURPOSE: The purpose of this study was to describe and diagnose the difficulty in a long-term follow-up (eleven years) patient with a very early presentation of late-onset retinal degeneration (L-ORD) and the significance of electrophysiological examinations and follow-up in assessing undiagnosed inherited retinal diseases. METHODS: This is an observational case report of a 56-year-old woman, with scattered multiple yellow-white retinal dots firstly diagnosed as fundus albipunctatus...
December 21, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37938426/iscev-standard-pattern-reversal-vep-development-paediatric-reference-limits-from-649-healthy-subjects
#14
JOURNAL ARTICLE
Dorothy A Thompson, Eszter Mikó-Baráth, Sharon E Hardy, Gábor Jandó, Martin Shaw, Ruth Hamilton
PURPOSE: To establish the extent of agreement for ISCEV standard reference pattern reversal VEPs (prVEPs) acquired at three European centres, to determine any effect of sex, and to establish reference intervals from birth to adolescence. METHODS: PrVEPs were recorded from healthy reference infants and children, aged 2 weeks to 16 years, from three centres using closely matched but non-identical protocols. Amplitudes and peak times were modelled with orthogonal quadratic and sigmoidal curves, respectively, and two-sided limits, 2...
November 8, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37924416/cone-driven-strong-flash-electroretinograms-in-healthy-adults-prevalence-of-negative-waveforms
#15
JOURNAL ARTICLE
Xiaofan Jiang, Taha Bhatti, Ambreen Tariq, Shaun M Leo, Nancy Aychoua, Andrew R Webster, Pirro G Hysi, Christopher J Hammond, Omar A Mahroo
PURPOSE: Both rod and cone-driven signals contribute to the electroretinogram (ERG) elicited by a standard strong flash in the dark. Negative ERGs usually reflect inner retinal dysfunction. However, in diseases where rod photoreceptor function is selectively lost, a negative waveform might represent the response of the dark-adapted cone system. To investigate the dark-adapted cone-driven waveform in healthy individuals, we delivered flashes on a dim blue background, designed to saturate the rods, but minimally adapt the cones...
November 4, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37889400/the-diagnostic-accuracy-of-photopic-negative-responses-evoked-by-broadband-and-chromatic-stimuli-in-a-clinically-heterogeneous-population
#16
JOURNAL ARTICLE
Shaun M Leo, Magella M Neveu, Patrick Yu-Wai-Man, Omar A Mahroo, Anthony G Robson
PURPOSE: To compare the diagnostic accuracy of the photopic negative response (PhNR) elicited by red-blue (RB) and white-white (WW) stimuli, for detection of retinal ganglion cell (RGC) dysfunction in a heterogeneous clinical cohort. METHODS: Adults referred for electrophysiological investigations were recruited consecutively for this single-centre, prospective, paired diagnostic accuracy study. PhNRs were recorded to red flashes (1.5 cd·s·m-2 ) on a blue background (10 cd·m-2 ) and to white flashes on a white background (the latter being the ISCEV standard LA 3 stimulus)...
October 27, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37804373/a-novel-pathogenic-crb1-variant-presenting-as-leber-congenital-amaurosis-8-and-evaluation-of-gene-editing-feasibility
#17
JOURNAL ARTICLE
Mohamed M Sylla, Masha Kolesinkova, Bruna Lopes da Costa, Irene H Maumenee, Stephen H Tsang, Peter M J Quinn
INTRODUCTION: Leber Congenital Amaurosis (LCA) is an inherited retinal disease that presents in infancy with severely decreased vision, nystagmus, and extinguished electroretinography findings. LCA8 is linked to variants in the Crumbs homolog 1 (CRB1) gene. CASE DESCRIPTION: We report a novel CRB1 variant in a 14-year-old male presenting with nystagmus, worsening vision, and inability to fixate on toys in his infancy. Color fundus photography revealed nummular pigments in the macula and periphery...
October 7, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37787933/accelerated-hydroxychloroquine-toxic-retinopathy
#18
JOURNAL ARTICLE
Ayushi Mohapatra, Prasad Gupta, Dhanashree Ratra
PURPOSE: To report a case series of patients with retinal toxicity due to hydroxychloroquine (HCQ) within a short span of treatment. METHODS: A retrospective review of case records of patients with accelerated HCQ toxicity within 1 year of starting the treatment was done. Systemic co-morbidities, details of HCQ treatment, details of ocular examination, and results of multimodal investigations were noted. RESULTS: Nine patients (1 male, 8 females) with age ranging from 40 to 73 years (mean 54...
October 3, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37495830/foveal-avascular-zone-size-and-mferg-metrics-in-diabetes-and-prediabetes-a-pilot-study-of-the-relationship-between-structure-and-function
#19
JOURNAL ARTICLE
Allison Jussel Zagst, Jennyffer D Smith, Rachel Wang, Wendy W Harrison
PURPOSE: Previous studies have demonstrated functional and structural retinal changes in type 2 diabetes (T2DM). However, less is understood in prediabetes, which is an important precursor to T2DM. Here, we evaluate the microvasculature structure of the foveal avascular zone (FAZ) and how it is correlated with retinal function as measured by the multifocal electroretinogram (mfERG) across levels of glucose dysfunction to uncover how T2DM and prediabetes alter this structure-function relationship...
October 2023: Documenta Ophthalmologica. Advances in Ophthalmology
https://read.qxmd.com/read/37775646/a-natural-history-study-of-autosomal-dominant-gucy2d-associated-cone-rod-dystrophy
#20
JOURNAL ARTICLE
Amanda J Scopelliti, Robyn V Jamieson, Elizabeth H Barnes, Benjamin Nash, Sulekha Rajagopalan, Elisa L Cornish, John R Grigg
PURPOSE: To describe the natural history of autosomal dominant (AD) GUCY2D-associated cone-rod dystrophies (CRDs), and evaluate associated structural and functional biomarkers. METHODS: Retrospective analysis was conducted on 16 patients with AD GUCY2D-CRDs across two sites. Assessments included central macular thickness (CMT) and length of disruption to the ellipsoid zone (EZ) via optical coherence tomography (OCT), electroretinography (ERG) parameters, best corrected visual acuity (BCVA), and fundus autofluorescence (FAF)...
September 29, 2023: Documenta Ophthalmologica. Advances in Ophthalmology
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