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Documenta Ophthalmologica. Advances in Ophthalmology

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https://www.readbyqxmd.com/read/28702796/accuracy-of-isolated-check-visual-evoked-potential-technique-for-diagnosing-primary-open-angle-glaucoma
#1
Li Juan Xu, Liang Zhang, Sha Ling Li, Vance Zemon, Gianni Virgili, Yuan Bo Liang
PURPOSE: The aim of this study was to determine the diagnostic accuracy, sensitivity and specificity of isolated-check visual evoked potentials (icVEP) in primary open-angle glaucoma (POAG). METHODS: Ninety POAG patients and sixty-six healthy controls were recruited consecutively. All subjects underwent icVEP and visual field testing. Swept icVEP response functions were obtained by increasing contrast in six stimulus steps, recording the electroencephalogram synchronized to the stimulus display's frame rate and calculating the corresponding signal-to-noise ratio (SNR) of the response at the fundamental frequency to evaluate visual function...
July 12, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28638951/isoflurane-and-ketamine-xylazine-differentially-affect-intraocular-pressure-associated-scotopic-threshold-responses-in-sprague-dawley-rats
#2
Vivian Choh, Akshay Gurdita, Bingyao Tan, Yunwei Feng, Kostadinka Bizheva, Daphne L McCulloch, Karen M Joos
PURPOSE: Amplitudes of electroretinograms (ERG) are enhanced during acute, moderate elevation of intraocular pressure (IOP) in rats anaesthetised with isoflurane. As anaesthetics alone are known to affect ERG amplitudes, the present study compares the effects of inhalant isoflurane and injected ketamine:xylazine on the scotopic threshold response (STR) in rats with moderate IOP elevation. METHODS: Isoflurane-anaesthetised (n = 9) and ketamine:xylazine-anaesthetised (n = 6) rats underwent acute unilateral IOP elevation using a vascular loop anterior to the equator of the right eye...
June 21, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28612321/the-changing-shape-of-the-iscev-standard-pattern-onset-vep
#3
Dorothy A Thompson, Dennis M Fritsch, Sharon E Hardy
PURPOSE: Pattern onset VEPs do not always show distinct C1-C2-C3 peaks and troughs. Our purpose was to study changes in pattern onset VEP with age to determine when the illustrated ISCEV standard onset VEP waveform can be reliably recorded. METHODS: We recorded pattern onset VEPs from an Oz electrode referred to mid-frontal electrode according to ISCEV standards by presenting checks of 60' and 15' side length in a 15° field. Twenty-four adults aged 20-63 years participated...
June 13, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28593392/multimodal-imaging-and-functional-correlations-identify-unusual-cases-of-macular-retinal-pigment-epithelium-hypopigmentation-occurring-without-functional-loss
#4
E Boulanger-Scemama, J Akesbi, S Tick, S Mohand-Said, J-A Sahel, I Audo
PURPOSE: Patients with unusual macular retinal pigment epithelium (RPE) hypopigmentation are described and analyzed using retinal multimodal imaging. METHODS: We report three cases of patients with unilateral (2) or bilateral (1) macular lesions discovered incidentally on fundoscopy. A comprehensive ophthalmic examination including visual acuity, fundoscopy, spectral-domain optical coherence tomography (SD-OCT), short-wavelength light and near-infrared autofluorescence, fluorescein angiography, microperimetry, multifocal electroretinogram, adaptive optics (AO), and OCT-angiography (OCT-A) has been performed...
June 7, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28593391/wavelet-decomposition-analysis-in-the-two-flash-multifocal-erg-in-early-glaucoma-a-comparison-to-ganglion-cell-analysis-and-visual-field
#5
Livia M Brandao, Matthias Monhart, Andreas Schötzau, Anna A Ledolter, Anja M Palmowski-Wolfe
PURPOSE: To further improve analysis of the two-flash multifocal electroretinogram (2F-mfERG) in glaucoma in regard to structure-function analysis, using discrete wavelet transform (DWT) analysis. METHODS: Sixty subjects [35 controls and 25 primary open-angle glaucoma (POAG)] underwent 2F-mfERG. Responses were analyzed with the DWT. The DWT level that could best separate POAG from controls was compared to the root-mean-square (RMS) calculations previously used in the analysis of the 2F-mfERG...
June 7, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28567618/ganglion-cell-loss-in-early-glaucoma-as-assessed-by-photopic-negative-response-pattern-electroretinogram-and-spectral-domain-optical-coherence-tomography
#6
Barbara Cvenkel, Maja Sustar, Darko Perovšek
PURPOSE: To evaluate discrimination ability of pattern electroretinography (PERG) and photopic negative response (PhNR) between early glaucoma and healthy controls, and their relationship with structural measurements using spectral-domain optical coherence tomography (SD-OCT). METHODS: Cross-sectional study with 34 patients with ocular hypertension (n = 7), suspect glaucoma (n = 17), and early glaucoma (n = 10), plus 24 age-matched controls. The following parameters were analyzed: P50 and N95 amplitude of the PERG, PhNR amplitude and PhNR/b-wave ratio, peripapillary retinal and macular nerve fiber layer (NFL) thicknesses, and ganglion cell complex (GCC) thickness...
May 31, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28560498/gender-based-normative-values-for-pattern-reversal-and-flash-visually-evoked-potentials-under-binocular-and-monocular-stimulation-in-healthy-adults
#7
Patrícia de Freitas Dotto, Adriana Berezovsky, Paula Yuri Sacai, Daniel Martins Rocha, Solange Rios Salomão
PURPOSE: To determine gender-based normative values for pattern-reversal (PR) and flash (F) visually evoked potentials (VEP) under binocular and monocular stimulation in healthy adults. METHODS: Healthy adults (age ≥18 years) were recruited among university employees and students. Inclusion criteria were absence of abnormalities in fundoscopy, tracking ability, stereopsis and pupillary reflexes; best-corrected visual acuity ≤.00 logMAR; and refractive error (spherical equivalent) from -6...
May 30, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28508299/intensity-response-function-of-the-photopic-negative-response-phnr-effect-of-age-and-test-retest-reliability
#8
Nabin R Joshi, Emma Ly, Suresh Viswanathan
PURPOSE: To assess the effect of age and test-retest reliability of the intensity response function of the full-field photopic negative response (PhNR) in normal healthy human subjects. METHODS: Full-field electroretinograms (ERGs) were recorded from one eye of 45 subjects, and 39 of these subjects were tested on two separate days with a Diagnosys Espion System (Lowell, MA, USA). The visual stimuli consisted of brief (<5 ms) red flashes ranging from 0.00625 to 6...
May 15, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28451988/correlation-of-macular-structure-and-function-in-a-boy-with-primary-foveomacular-retinitis-and-sequence-of-changes-over-5%C3%A2-years
#9
Anurag Badhani, Tapas Ranjan Padhi, Gopal Krishna Panda, Sujoy Mukherjee, Taraprasad Das, Subhadra Jalali
PURPOSE: To describe the clinical characteristics, macular structure and function, and to document sequential changes over 5 years in a 10-year-old boy with bilateral primary foveomacular retinitis. METHODS: A 10-year-old boy presented with sudden onset scotoma in both eyes, experienced after getting up from bed on a non-eclipse day. He persistently denied direct sun-gazing. He neither had any significant systemic illness, nor was using any medications. In addition to a detailed examination at presentation that included fundus fluorescein angiogram (FFA), electroretinogram (ERG), pattern ERG and electrooculogram (EOG), he was examined periodically for 5 years with Humphrey visual field (HVF), spectral domain optical coherence tomogram (SDOCT), Amsler grid charting and multifocal ERG...
April 27, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28451987/erg-and-other-discriminators-between-advanced-hydroxychloroquine-retinopathy-and-retinitis-pigmentosa
#10
Archana A Nair, Michael F Marmor
PURPOSE: To study whether the ERG and other clinical findings help to distinguish between advanced hydroxychloroquine (HCQ) retinopathy and pericentral or diffuse retinitis pigmentosa (RP) with similar fundus appearance. METHODS: We conducted a retrospective analysis of patients with advanced HCQ retinopathy (n = 11), pericentral RP (n = 8) and diffuse RP (n = 8). Pericentral RP was defined as having limited fundus damage and relatively normal flicker ERG time-to-peak...
June 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28421377/vep-and-perg-in-patients-with-multiple-sclerosis-with-and-without-a-history-of-optic-neuritis
#11
M Janáky, Á Jánossy, G Horváth, G Benedek, G Braunitzer
PURPOSE: Visual electrophysiology is routinely used to detect the visual complications of multiple sclerosis, but the analysis mostly focuses on visual evoked potential (VEP) and especially the P100 component. Our goal was to analyze the components and waveform alterations of VEPs and pattern electroretinograms (PERGs) in patients with multiple sclerosis (MS) with good vision. METHODS: The main VEP and PERG components of 85 patients with MS were analyzed in two groups: 38 patients who had optic neuritis in their history (ON group) and 47 patients who had never had optic neuritis (MS group)...
June 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28389912/pigmented-and-albino-rats-differ-in-their-responses-to-moderate-acute-and-reversible-intraocular-pressure-elevation
#12
Akshay Gurdita, Bingyao Tan, Karen M Joos, Kostadinka Bizheva, Vivian Choh
PURPOSE: To compare the electrophysiological and morphological responses to acute, moderately elevated intraocular pressure (IOP) in Sprague-Dawley (SD), Long-Evans (LE) and Brown Norway (BN) rat eyes. METHODS: Eleven-week-old SD (n = 5), LE (n = 5) and BN (n = 5) rats were used. Scotopic threshold responses (STRs), Maxwellian flash electroretinograms (ERGs) or ultrahigh-resolution optical coherence tomography (UHR-OCT) images of the rat retinas were collected from both eyes before, during and after IOP elevation of one eye...
June 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28382556/acute-progressive-paravascular-placoid-neuroretinopathy-with-negative-type-electroretinography-in-paraneoplastic-retinopathy
#13
Fred K Chen, Avenell L Chew, Dan Zhang, Shang-Chih Chen, Enid Chelva, Erandi Chandrasekera, Eleanor M H Koay, John Forrester, Samuel McLenachan
PURPOSE: Paraneoplastic retinopathy can be the first manifestation of systemic malignancy. A subset of paraneoplastic retinopathy is characterized by negative-type electroretinography (ERG) without fundus abnormality. Here we describe the multimodal imaging and clinico-pathological correlation of a unique case of acute progressive paravascular placoid neuroretinopathy with suspected retinal depolarizing bipolar cell dysfunction preceding the diagnosis of metastatic small cell carcinoma of the prostate...
June 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28349282/detailed-electroretinographic-findings-in-rd8-mice
#14
Alan B Saul, Xuezhi Cui, Shanu Markand, Sylvia B Smith
PURPOSE: Previous work has suggested that the retinal degeneration mutant rd8 mouse lacks an electroretinographic (ERG) phenotype until about 9 months of age. We evaluated the ERG phenotype of these mice by measuring both conventional ERG responses and scotopic threshold responses. METHODS: Groups of 4-month-old wild-type (WT) and mutant (rd8) mice were anesthetized and tested for mass retinal responses (ERGs) to several types of visual stimuli. Scotopic threshold responses were accumulated with brief scotopic flashes at a series of very dim intensities...
June 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28332008/case-of-adult-onset-neuronal-intranuclear-hyaline-inclusion-disease-with-negative-electroretinogram
#15
Wataru Yamada, Akira Takekoshi, Kyoko Ishida, Kiyofumi Mochizuki, Jun Sone, Gen Sobue, Yuichi Hayashi, Takashi Inuzuka, Yozo Miyake
PURPOSE: To report the findings in a 72-year-old man with neuronal intranuclear hyaline inclusion disease (NIHID) with the negative-type electroretinogram (ERG) and without night blindness. METHODS: Standard ophthalmological examinations including the medical history, measurements of the best-corrected visual acuity and intraocular pressures, slit-lamp biomicroscopy, ophthalmoscopy, spectral-domain optical coherence tomography, fundus autofluorescence, and perimetry were performed...
June 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28315987/early-postoperative-evaluation-of-retinal-function-by-electroretinography-after-vitreous-surgery-for-idiopathic-epimacular-membrane
#16
Akira Watanabe, Tamaki Gekka, Kota Arai, K Kohzaki, Hiroshi Tsuneoka
PURPOSE: In this study, we used the PuREC to carry out electroretinography (ERG) measurements using skin electrodes to assess changes before and after microincision vitreous surgery (MIVS) for epiretinal membrane (ERM) and evaluate the stress on retinal function soon after MIVS. METHODS: The study subjects were 18 eyes of 18 patients who underwent MIVS for ERM simultaneously with cataract surgery. ERG measurements were performed using a skin electrode on the day before vitreous surgery, on the day after surgery, and 1 week later...
June 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28303363/test-retest-reliability-of-scotopic-full-field-electroretinograms-in-rabbits
#17
Jan Luebke, Alexandra Anton, Michael Bach
PURPOSE: To explore test-retest reliability of standard scotopic full-field ERG measurements in New Zealand White rabbits. The ERG is widely used for testing of retinal integrity after any ocular treatment. We here present detailed stimulus-response dependencies for single healthy and untreated animals, concentrating on test-retest reproducibility. MATERIALS AND METHODS: Five New Zealand White rabbits (aged 8-10 weeks, weight about 2.0-2.5 kg) underwent binocular ERG measurements after intramuscular anesthesia and pharmaceutical pupillary dilatation at a baseline day and 10 days later...
June 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28281104/electroretinogram-and-visual-field-changes-in-a-case-of-birdshot-chorioretinopathy
#18
Hisham Elbaz, Volker Besgen, Klara Rechberger, Walter Sekundo, Eckart Apfelstedt-Sylla
PURPOSE: This case report explores the role of the visual field perimetry and electroretinogram (ERG) in cases of non-infectious uveitis in the assessment and monitoring of retinal function and response to treatment. METHODS: A 59-year-old Caucasian female presenting with bilateral posterior uveitis newly diagnosed as birdshot chorioretinopathy (BSCR) presenting with bilateral decrease in visual acuity and cystoid macular edema, as well as a paracentral scotoma in the right eye...
April 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28243926/comparing-three-different-modes-of-electroretinography-in-experimental-glaucoma-diagnostic-performance-and-correlation-to-structure
#19
Laura Wilsey, Sowjanya Gowrisankaran, Grant Cull, Christy Hardin, Claude F Burgoyne, Brad Fortune
PURPOSE: To compare diagnostic performance and structure-function correlations of multifocal electroretinogram (mfERG), full-field flash ERG (ff-ERG) photopic negative response (PhNR) and transient pattern-reversal ERG (PERG) in a non-human primate (NHP) model of experimental glaucoma (EG). METHODS: At baseline and after induction of chronic unilateral IOP elevation, 43 NHP had alternating weekly recordings of retinal nerve fiber layer thickness (RNFLT) by spectral domain OCT (Spectralis) and retinal function by mfERG (7F slow-sequence stimulus, VERIS), ff-ERG (red 0...
April 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28224239/the-importance-of-electrode-position-in-visual-electrophysiology
#20
A Kurtenbach, S Kramer, T Strasser, E Zrenner, H Langrová
PURPOSE: The DTL fibre electrode is commonly used to record the electric potentials elicited by stimulation of the retina. Two positions are commonly used: it is placed either on the cornea along the lower lid or in the conjunctival fornix. The PERG and OPs have previously been examined and compared under both conditions. The aim of this study was to examine the ERG, flicker response and on-off responses with differing electrode positions. METHODS: Before recruitment, all subjects underwent an ophthalmological examination...
April 2017: Documenta Ophthalmologica. Advances in Ophthalmology
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