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Documenta Ophthalmologica. Advances in Ophthalmology

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https://www.readbyqxmd.com/read/29139045/electroretinography-in-idiopathic-intracranial-hypertension-comparison-of-the-pattern-erg-and-the-photopic-negative-response
#1
Jason C Park, Heather E Moss, J Jason McAnany
PURPOSE: To evaluate the relationship between electrophysiological measures of retinal ganglion cell (RGC) function in patients who have idiopathic intracranial hypertension (IIH). METHODS: The pattern electroretinogram (pERG) and photopic negative response (PhNR) were recorded from 11 IIH patients and 11 age-similar controls. The pERG was elicited by a contrast-reversing checkerboard. The PhNR, a slow negative component following the flash ERG b-wave, was recorded in response to a long-wavelength flash presented against a short-wavelength adapting field...
November 14, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29134296/p300-based-acuity-estimation-in-imitated-amblyopia
#2
Marvin L Beusterien, Sven P Heinrich
PURPOSE: A frequent approach to estimating visual acuity objectively is the recording of visual evoked potentials (VEPs) to patterns of different coarseness. This, however, overestimates acuity in patients with fragmented and distorted vision such as in amblyopia. This is likely due to VEP-based techniques using checkerboard or grating stimuli. We hypothesized that no overestimation would occur when the event-related potential P300 in response to optotype stimuli is used for acuity estimation...
November 13, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29134295/rod-versus-cone-driven-ergs-at-different-stimulus-sizes-in-normal-subjects-and-retinitis-pigmentosa-patients
#3
Avinash J Aher, Declan J McKeefry, Neil R A Parry, John Maguire, I J Murray, Tina I Tsai, Cord Huchzermeyer, Jan Kremers
PURPOSE: To study how rod- and cone-driven responses depend on stimulus size in normal subjects and patients with retinitis pigmentosa (RP), and to show that comparisons between responses to full-field (FF) and smaller stimuli can be useful in diagnosing and monitoring disorders of the peripheral retina without the need for lengthy dark adaptation periods. METHOD: The triple silent substitution technique was used to isolate L-cone-, M-cone- and rod-driven ERGs with 19, 18 and 33% photoreceptor contrasts, respectively, under identical mean luminance conditions...
November 13, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29128949/elvisml-an-open-data-format-for-the-exchange-and-storage-of-electrophysiological-data-in-ophthalmology
#4
Torsten Strasser, Tobias Peters, Herbert Jägle, Eberhart Zrenner
PURPOSE: The ISCEV standards and recommendations for electrophysiological recordings in ophthalmology define a set of protocols with stimulus parameters, acquisition settings, and recording conditions, to unify the data and enable comparability of results across centers. Up to now, however, there are no standards to define the storage and exchange of such electrophysiological recordings. The aim of this study was to develop an open standard data format for the exchange and storage of visual electrophysiological data (ElVisML)...
November 11, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29124422/perifoveal-interdigitation-zone-loss-in-hydroxychloroquine-toxicity-leads-to-subclinical-bull-s-eye-lesion-appearance-on-near-infrared-reflectance-imaging
#5
Avenell L Chew, Danuta M Sampson, Enid Chelva, Jane C Khan, Fred K Chen
PURPOSE: To characterize the ultrastructural and functional correlates of hydroxychloroquine (HCQ)-induced subclinical bull's eye lesion seen on near-infrared reflectance (NIR) imaging. METHODS: An asymptomatic 54-year-old male taking HCQ presented with paracentral ring-like scotoma, abnormal multifocal electroretinography (mfERG) and preserved ellipsoid zone on optical coherence tomography (OCT). Dense raster OCT was performed to create en face reflectivity maps of the interdigitation zone...
November 9, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29027635/international-society-for-clinical-electrophysiology-of-vision-miami-fl-usa-55th-annual-symposium-october-21-26-2017
#6
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29027143/iscev-2017-symposium-program-listing-in-chronological-order
#7
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29027142/55th-annual-symposium-of-the-international-society-for-clinical-electrophysiology-of-vision-iscev-2017
#8
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29027141/iscev-2017-symposium-author-index
#9
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29019002/a-meta-analysis-of-clinical-electro-oculography-values
#10
Paul A Constable, David Ngo, Stephen Quinn, Dorothy A Thompson
BACKGROUND: The aim of the meta-analysis was to derive a range of mean normal clinical electrooculogram (EOG) values from a systematic review of published EOG studies that followed the guidelines of the ISCEV standard for clinical electro-oculography. METHODS: A systematic literature review was performed using four relevant databases limited to peer-reviewed articles in English between 1967 and February 2017. Studies reporting clinical EOG or FO normal values were included when the report used a standard 30° horizontal saccade, a retinal luminance of between 100 and 250 cd m(-2), and had > 10 subjects in their normative values...
December 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28980154/vep-based-acuity-assessment-in-low-vision
#11
Michael B Hoffmann, Jan Brands, Wolfgang Behrens-Baumann, Michael Bach
PURPOSE: Objective assessment of visual acuity (VA) is possible with VEP methodology, but established with sufficient precision only for vision better than about 1.0 logMAR. We here explore whether this can be extended down to 2.0 logMAR, highly desirable for low-vision evaluations. METHODS: Based on the stepwise sweep algorithm (Bach et al. in Br J Ophthalmol 92:396-403, 2008) VEPs to monocular steady-state brief onset pattern stimulation (7.5-Hz checkerboards, 40% contrast, 40 ms on, 93 ms off) were recorded for eight different check sizes, from 0...
December 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28975461/measurement-of-dark-adaptometry-during-iscev-standard-flash-electroretinography
#12
Jeff Rabin, Brooke Houser, Carolyn Talbert, Rue Patel
PURPOSE: Dark adaptometry (DA) is a sensitive test for diagnosis of retinal disease. Patients requiring flash electroretinograms (ERGs) benefit from DA for proper diagnosis. Our purpose was to develop a DA test to be administered during the 20-min dark adaptation period of the flash ERG ( www.iscev.org ) using alternating red and blue stimuli to bias responses in favor of cones (red) and rods (blue). METHODS: An ERG Ganzfeld was used to measure DA in 21 normal subjects and 21 patients with retinal disease...
December 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28900746/electrophysiological-features-and-multimodal-imaging-in-ritonavir-related-maculopathy
#13
Céline Faure, Michel Paques, Isabelle Audo
PURPOSE: The purpose of this study is to report a case of ritonavir-related retinal toxicity followed over a year. Electrophysiological features and multimodal imaging, including adaptive optics, are provided and discussed. METHODS: Electrophysiological recordings and multimodal imaging were performed and repeated over 1 year. RESULTS: Fundus examination revealed crystalline maculopathy in conjunction with pigment disruption. Spectral domain optical coherence tomography displayed thinning of the macula without cysts...
December 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28852896/retinal-toxicity-related-to-hydroxychloroquine-in-patients-with-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#14
Hande Husniye Telek, Nilufer Yesilirmak, Gulten Sungur, Yaprak Ozdemir, Nesibe Karahan Yesil, Firdevs Ornek
PURPOSE: To compare the retinal toxicity due to hydroxychloroquine (HCQ) use in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) using multifocal electroretinography (mfERG), fundus autofluorescence (FAF) and optical coherence tomography (OCT). METHODS: Patients who were using HCQ due to SLE and RA, and healthy subjects evaluated in this study. Central foveal thickness (CFT), inner-outer segment (IS-OS) junction irregularity, retinal nerve fiber layer thickness, mfERG and FAF measurements were performed to evaluate retinal toxicity...
December 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28825191/infliximab-exerts-a-dose-dependent-effect-on-retinal-safety-in-the-albino-rabbit
#15
Shiri Zayit-Soudry, Igor Vainer, Esther Zemel, Michael Mimouni, Melvin Rabena, Dante J Pieramici, Ido Perlman, Anat Loewenstein
PURPOSE: To assess the retinal toxicity of an intravitreal injection of infliximab, a monoclonal antibody to tumor necrosis factor α, in a rabbit model. MATERIALS AND METHODS: Two groups of adult albino rabbits (n = 5) received intravitreal injections of infliximab (0.1 ml) in the study eye and balanced salt solution (BSS, 0.1 ml) in the control eye at baseline. Group 1 was administered with 1.5 mg/0.1 ml, and group 2 was injected with 7.5 mg/0.1 ml of infliximab solution...
December 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28815346/unilateral-cancer-associated-retinopathy-diagnosis-serology-and-treatment
#16
Dimitri Roels, Shinji Ueno, Cornelia D Talianu, Dafina Draganova, Mineo Kondo, Bart P Leroy
PURPOSE: To report a case of unilateral cancer-associated retinopathy (CAR) with clinical, serological and electroretinogram (ERG) normalization after aggressive cancer treatment combined with steroids and rituximab. METHODS: Work-up included extensive clinical and electrophysiological testing. Also, serological work-up for antiretinal antibodies and oncological screening was organized. RESULTS: A 45-year-old female presented with progressive photopsias, photophobia and relative central scotoma in the right eye since 6 weeks prior...
December 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28756595/structural-and-functional-assessment-after-intravitreal-injection-of-ranibizumab-in-diabetic-macular-edema
#17
YuDong Fu, Ping Wang, XuXia Meng, Zhaodong Du, DaBo Wang
PURPOSE: To evaluate structure and function improvement in central retina by optical coherence tomography (OCT) and multifocal electroretinography (mf-ERG) in diabetic macular edema (DME) patients after intravitreal injection of ranibizumab (IVR) treatment. METHODS: Twenty-seven eyes in 27 patients with DME received three consecutive monthly injections of IVR (0.05 ml, 10 mg/ml) and as needed thereafter. The clinical parameters of best-corrected visual acuity (BCVA), central foveal thickness (CFT) and mf-ERG were monitored for 6 months before and after IVR...
December 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28795295/predictive-value-of-n95-waveforms-of-pattern-electroretinograms-pergs-in-children-with-optic-nerve-hypoplasia-onh
#18
Daphne McCulloch, Pamela Garcia-Filion, Cassandra Fink, Anthony C Fisher, Antonio Eleuteri, Mark S Borchert
PURPOSE: As part of a long-term, prospective study of prenatal and clinical risk factors for optic nerve hypoplasia (ONH) at Children's Hospital Los Angeles, pattern ERGs (PERGs) were evaluated for prognostic value using an automated objective and robust analytical method. METHODS: Participants were 33 children with ophthalmoscopically diagnosed ONH [disc diameter-to-disc macula ratio (DD/DM) less than 0.35 in one or both eyes on fundus photographs]. Using cycloplegia and chloral hydrate sedation in one session before 26 months of age, we recorded PERGs to checkerboard reversal using five check sizes...
October 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28779336/multifocal-electroretinography-changes-at-the-1-year-follow-up-in-a-cohort-of-diabetic-macular-edema-patients-treated-with-ranibizumab
#19
Marc Baget-Bernaldiz, Pedro Romero-Aroca, Angel Bautista-Perez, Joaquin Mercado
PURPOSE: To determine the changes in the multifocal electroretinogram (mfERG) at 1 year in a clinical series of diabetic macular edema (DME) patients treated with ranibizumab (RNBZ) using a pro re nata protocol. METHODS: We analyzed a clinical series of 35 eyes of 35 patients with DME at baseline and after treating them with RNBZ over 1 year, in order to determine the change in the macular function, which was assessed by means of the response density and the implicit time of the first-order kernel (FOK) P1 wave of the mfERG at the foveola (R1), fovea (R2) and parafovea (R3)...
October 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28756596/new-photic-stimulating-system-with-white-light-emitting-diodes-to-elicit-electroretinograms-from-zebrafish-larvae
#20
Hisashi Matsubara, Yoshitsugu Matsui, Ryohei Miyata, Yuhei Nishimura, Tetsuro Yamamoto, Toshio Tanaka, Mineo Kondo
PURPOSE: The zebrafish is an established animal model commonly used in biological, neuroscience, and genetic research. We have developed a new light stimulating system using white light-emitting diodes (LEDs) to elicit ERGs from zebrafish larvae. The purpose of this study was to record full-field ERGs and to evaluate the inter-trial reliability of the ERGs recorded with our system from zebrafish larvae. METHODS: The stimulating device used white LEDs that were attached to a stereomicroscope, and the location of the recording electrode on the cornea could be monitored while the eye was being stimulated...
October 2017: Documenta Ophthalmologica. Advances in Ophthalmology
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