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Documenta Ophthalmologica. Advances in Ophthalmology

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https://www.readbyqxmd.com/read/30417311/modified-erg-jet%C3%A2-contact-lens-electrodes-for-use-in-infants-and-toddlers-update
#1
Scott E Brodie
PURPOSE: To describe recent changes in the dimensions of the ERG-jet contact lens electrode, and to suggest corresponding changes in the dimensions of cylindrical stents to facilitate the use of ERG-jet contact lens electrodes in infants and small children. METHODS: Upon the observation that existing cylindrical stents no longer fit newly purchased ERG-jet contact lenses, the spacings between the "bumps" on the front surface of old and new electrodes were measured with calipers, and prototype stents were newly machined from acrylic plastic...
November 11, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30411184/consecutive-unilateral-recording-of-the-two-eyes-affects-dark-adapted-erg-responses-when-compared-to-simultaneous-bilateral-recording
#2
Maya Ross, Hen Honig, Raaya Ezra-Elia, Eyal Banin, Alexey Obolensky, Edward Averbukh, Alexander Rosov, Elisha Gootwine, Ron Ofri
PURPOSE: Our aim was to compare the electroretinographic (ERG) responses of two eyes obtained by consecutive unilateral recordings to those obtained by a simultaneous bilateral recording in sheep. METHODS: Eight sheep underwent two full-field ERG recordings, using two recording strategies of the standard ISCEV protocol: consecutive unilateral recordings of one eye after the other, and simultaneous bilateral recording of both eyes. The order of recording strategy within an animal (unilateral/bilateral), eye recording sequence in the unilateral session (OD/OS), and amplifier channel assignment for each eye were all randomized...
November 9, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30374652/the-importance-of-the-electrophysiological-tests-in-the-early-diagnosis-of-ganglion-cells-and-or-optic-nerve-dysfunction-coexisting-with-pituitary-adenoma-an-overview
#3
REVIEW
Ewelina Lachowicz, Wojciech Lubiński
BACKGROUND AND METHODS: Based on the available literature, it is suggested, in the clinical evaluation of the chiasmal tumors, that the following electrophysiological tests: visual evoked potentials to pattern-reversal stimulation, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (PERG) play an important role in the diagnosis of the optic nerve and retinal dysfunction in the course of pituitary tumors. RESULTS: Macroadenomas and also microadenomas may cause dysfunction of retinal ganglion cells (RGCs) and their axons, even in the absence of changes in the routine ophthalmological examination, retinal sensitivity in standard automated perimetry, and retinal nerve fiber layer thickness in optical coherent tomography...
October 29, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30368631/evaluating-the-neuroprotective-effect-of-17%C3%AE-estradiol-in-rodent-models-of-oxidative-retinopathies
#4
Samaneh Chaychi, Anna Polosa, Sylvain Chemtob, Pierre Lachapelle
PURPOSE: To determine the neuroprotective effect of estrogen on the structure and function of the retina exposed to an oxidative stress. METHODS: Male Sprague-Dawley rat pups were exposed to either hyperoxia (O2 E: from P8 to P14) or bright light (LE: from P14 to P28) with or without 17 β-estradiol (βE2 ) treatment. Retinal structure (histology) and function (ERG) were assessed at selected time points. RESULTS: In the O2 E model, βE2 injections caused a significant reduction of the ERG and a significantly thinner OPL compared to untreated oxygen-exposed group (O2 -exposed) rats...
October 27, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30357588/evaluation-of-light-and-dark-adapted-ergs-using-a-mydriasis-free-portable-system-clinical-classifications-and-normative-data
#5
Henry Liu, Xiang Ji, Sabrina Dhaliwal, Syeda Naima Rahman, Michelle McFarlane, Anupreet Tumber, Jeff Locke, Tom Wright, Ajoy Vincent, Carol Westall
PURPOSE: The full-field electroretinogram (ff-ERG) is a widely used clinical tool to evaluate generalized retinal function by recording electrical potentials generated by the cells in the retina in response to flash stimuli and requires mydriasis. The purpose of this study was to determine the intra-visit reliability and diagnostic capability of a handheld, mydriasis-free ERG, RETeval (LKC Technologies, Gaithersburg, MD, USA), in comparison with the standard clinical ff-ERG by measuring responses recommended by the International Society for Clinical Electrophysiology of Vision (ISCEV)...
October 24, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30334119/role-of-a-mydriasis-free-full-field-flicker-erg-device-in-the-detection-of-diabetic-retinopathy
#6
Mehmet Fatih Kağan Değirmenci, Sibel Demirel, Figen Batıoğlu, Emin Özmert
PURPOSE: To determine if the RETeval system can be used for the screening of diabetic retinopathy (DR) to provide early diagnosis. METHODS: The subjects were 42 diabetic patients selectively recruited by examination of their medical records to have varying severities of DR. The severity of DR was classified into four groups according to the International Clinical Diabetic Retinopathy Disease Severity Scale. Full-field electroretinograms (ERG) without mydriasis were obtained by the DR assessment protocol of the RETeval system...
October 17, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30306358/foveal-amplitudes-of-multifocal-electroretinograms-are-larger-following-full-field-electroretinograms
#7
Wendy Harrison, Kaila Osmotherly, Nathan Biancardi, Jamison Langston, Russell Gray, Taylor Kneip, Reese Loveless
PURPOSE: The clinical standards for multifocal electroretinograms (mfERG) call for adaption to normal room lighting before the mfERG begins. They specify that any assessments where bright lights are used, should be done after the mfERG to prevent excess stimulation of retinal cells. However, full-field electroretinograms (FFERG) are performed prior to mfERGs in some clinical settings. It is unclear from the literature whether the FFERG has an impact on the mfERG. This study seeks to examine the effect of the FFERG on the mfERG when performed sequentially...
October 10, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30209775/retinal-function-in-eyes-with-proliferative-diabetic-retinopathy-treated-with-intravitreal-ranibizumab-and-multispot-laser-panretinal-photocoagulation
#8
Katharina Messias, Rafael de Montier Barroso, Rodrigo Jorge, Andre Messias
PURPOSE: To compare retinal function changes in eyes with proliferative diabetic retinopathy (PDR) after intravitreal ranibizumab (IVR), combined or not with conventional (ETDRS) or multispot laser panretinal (PASCAL) photocoagulation (PRP). METHODS: This study included laser-naive PDR patients that required PRP. Eyes were randomly and prospectively assigned to receive IVR or IVR combined with PASCAL or EDTRS. PRP was performed at baseline in 1 (PASCAL) or 2 (ETDRS) sessions...
September 12, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30099644/a-novel-mutation-in-the-prpf31-in-a-north-indian-adrp-family-with-incomplete-penetrance
#9
Sofia Bhatia, Shiwali Goyal, Indu R Singh, Daljit Singh, Vanita Vanita
PURPOSE: To identify the underlying genetic defect for non-syndromic autosomal dominant retinitis pigmentosa (adRP) with incomplete penetrance in a North Indian family. METHODS: Family history and clinical data were collected. Linkage analysis using 72 fluorescently labeled microsatellite markers flanking all the 26 candidate genes known for adRP was performed. Mutation screening in candidate gene at the mapped region was performed by bi-directional DNA sequencing...
October 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30074097/transplantation-of-rat-embryonic-stem-cell-derived-retinal-cells-restores-visual-function-in-the-royal-college-of-surgeons-rats
#10
Hongxi Wu, Jia Li, Xinbang Mao, Guodong Li, Lin Xie, Zhipeng You
AIM OF STUDY: To evaluate the feasibility of transplantation of embryonic stem cell (ESC)-derived retinal cells in the treatment of retinal degeneration. MATERIALS AND METHODS: Rat ESCs were isolated and induced into retinal progenitor cells (RPCs) in vitro, which were subsequently induced into retinal pigment epithelium cells (RPEs) and photoreceptors (PRCs). All cells were identified by Western blot detection of their specific markers. RPEs and PRCs were, respectively, injected into the retina of Royal College of Surgeons (RCSs) rats...
October 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30051304/phenotypic-characterization-of-complete-csnb-in-the-inbred-research-beagle-how-common-is-csnb-in-research-and-companion-dogs
#11
Annie Oh, Ellis R Loew, Melanie L Foster, Michael G Davidson, Robert V English, Kristen J Gervais, Ian P Herring, Freya M Mowat
PURPOSE: Although congenital stationary night blindness (CSNB) has been described in a Japanese beagle dog research colony, certain clinical correlates with human CSNB have not yet been described, nor has an estimate of frequency of the condition been made in inbred and outbred beagle populations. METHODS: A beagle with CSNB obtained from a commercial research dog supplier in the USA and matched control dogs (n = 3) underwent examination, refraction, ocular imaging, assessment of visual navigation ability and detailed electroretinography (ERG)...
October 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30046929/effect-of-varying-skin-surface-electrode-position-on-electroretinogram-responses-recorded-using-a-handheld-stimulating-and-recording-system
#12
Angharad E Hobby, Diana Kozareva, Ekaterina Yonova-Doing, Ibtesham T Hossain, Mohamed Katta, Byki Huntjens, Christopher J Hammond, Alison M Binns, Omar A Mahroo
PURPOSE: A handheld device (the RETeval system, LKC Technologies) aims to increase the ease of electroretinogram (ERG) recording by using specially designed skin electrodes, rather than corneal electrodes. We explored effects of electrode position on response parameters recorded using this device. METHODS: Healthy adult twins were recruited from the TwinsUK cohort and underwent recording of light-adapted flicker ERGs (corresponding to international standard stimuli)...
October 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30051303/riggs-type-dominant-congenital-stationary-night-blindness-erg-findings-a-new-gnat1-mutation-and-a-systemic-association
#13
Michael F Marmor, Christina Zeitz
PURPOSE: Complete congenital stationary night blindness (CSNB) is most often x-linked or recessive, and associated with a transmission defect from photoreceptors to bipolar cells. This produces a characteristic "negative" Schubert-Bornschein type of scotopic rod-cone electroretinogram (ERG) with a large a-wave and minimal b-wave. CSNB from abnormalities in phototransduction can be recessive or dominant and is much less common. This produces a Riggs type of ERG with loss of the rod a-wave as well as the b-wave...
August 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30030672/clinical-display-of-mferg-data
#14
Michael F Marmor, Lorella Cabael
PURPOSE: Many mfERG displays show normal responses that are larger at the center than peripherally, and the typical linear display of signals is inaccurate with respect to the retinal location of the signals. Printouts do not always indicate retinal or field view, they sometimes emphasize 3-D topographic plots which are not always representative of physiologic signals, and they show ring response densities which are different in every ring and hard to interpret without norms. These problems limit the clinical usefulness of the mfERG and limit communication in the literature...
August 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/30027431/clinical-and-genetic-findings-of-a-japanese-patient-with-rp1-related-autosomal-recessive-retinitis-pigmentosa
#15
Kentaro Kurata, Katsuhiro Hosono, Yoshihiro Hotta
PURPOSE: This study reports the ophthalmic and genetic findings of a Japanese patient with autosomal recessive retinitis pigmentosa (arRP) caused by retinitis pigmentosa 1 (RP1) mutations. PATIENT AND METHODS: The 34-year-old female patient and her unaffected parents underwent comprehensive ophthalmic examinations, including visual acuity measurements, perimetry, electroretinography (ERG), and optical coherence tomography. Fundus autofluorescence was also evaluated in the patient...
August 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29968203/the-clinical-value-of-the-multi-channel-pvep-and-perg-in-the-diagnosis-and-management-of-the-patient-with-pituitary-adenoma-a-case-report
#16
Ewelina Lachowicz, Wojciech Lubiński
PURPOSE: To present a patient with a diagnosis of pituitary adenoma and progressive visual pathway dysfunction detected in the electrophysiological tests in one-year follow-up. Patient is a 59-year-old male with a non-secreting pituitary macroadenoma. METHODS: Routine ophthalmological evaluation, standard automatic perimetry (SAP), retinal nerve fibers layer and the ganglion cell complex thickness in optical coherent tomography (OCT), as well as electrophysiological examinations (pattern electroretinogram-PERG, multi-channel pattern visual evoked potentials-multi-channel PVEPs record according to ISCEV standards) were performed...
August 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29858967/dark-adapted-red-flash-ergs-in-healthy-adults
#17
R Hamilton, K Graham
PURPOSE: The x-wave of the dark-adapted (DA) ERG to a red flash reflects DA cone function. This exploratory study of healthy adults aimed to investigate changes in the DA red ERG with flash strength and during dark adaptation to optimise visualisation and therefore quantification of the x-wave. METHODS: The effect of altering red flash strength was investigated in four subjects by recording ERGs after 20 min dark adaptation to red flashes (0.2-2.0 cd s m-2 ) using skin electrodes and natural pupils...
August 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29987673/macular-staphyloma-in-patients-affected-by-joubert-syndrome-with-retinal-dystrophy-a-new-finding-detected-by-sd-oct
#18
Caterina Toma, Giulio Ruberto, Federico Marzi, Giulio Vandelli, Sabrina Signorini, Enza Maria Valente, Mauro Antonini, Chiara Bertone, Paolo Emilio Bianchi
PURPOSE: Joubert syndrome (JS) is an inherited autosomal recessive or X-lined disorder characterized by a congenital malformation of the mid-hindbrain and a large spectrum of clinical features. It is estimated that retinal dystrophy is present in association with the typical neurological findings in about one-third of the patients. The aim of this study is to better characterize the macular region in JS patients with and without retinal dystrophy. METHODS: We describe six individuals affected by JS as demonstrated by the presence of the typical "molar tooth sign" on MRI...
July 10, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29934802/iscev-extended-protocol-for-the-photopic-on-off-erg
#19
Maja Sustar, Graham E Holder, Jan Kremers, Claire S Barnes, Bo Lei, Naheed W Khan, Anthony G Robson
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On-Off ERG, and outlines common clinical applications. A light stimulus duration of 150-200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components. The On-response occurs after the stimulus onset and has a negative a-wave and positive b-wave...
June 22, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29934801/iscev-extended-protocol-for-the-dark-adapted-red-flash-erg
#20
Dorothy A Thompson, Kaoru Fujinami, Ido Perlman, Ruth Hamilton, Anthony G Robson
The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the dark-adapted (DA) red flash ERG. The DA red flash ERG can be incorporated conveniently within the ISCEV standard ERG protocol after a minimum of 20-min DA and recorded after the DA 0.01 ERG to a flash strength of 0.3 phot cd s m-2 , eliciting a waveform with two positive peaks in healthy individuals...
June 22, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
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