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British Journal of Cancer

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https://www.readbyqxmd.com/read/30116026/prognostic-role-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-patients-with-bone-metastases
#1
Quirina C B S Thio, W Alexander Goudriaan, Stein J Janssen, Nuno Rui Paulino Pereira, Daniel M Sciubba, Rachel P Rosovksy, Joseph H Schwab
BACKGROUND: Skeletal metastases are a common problem in patients with cancer, and surgical decision making depends on multiple factors including life expectancy. Identification of new prognostic factors can improve survival estimation and guide healthcare providers in surgical decision making. In this study, we aim to determine the prognostic value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with bone metastasis. METHODS: One thousand and twelve patients from two tertiary referral centers between 2002 and 2014 met the inclusion criteria...
August 17, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30116025/proteomic-phenotyping-of-metastatic-melanoma-reveals-putative-signatures-of-mek-inhibitor-response-and-prognosis
#2
Christoph Krisp, Robert Parker, Dana Pascovici, Nicholas K Hayward, James S Wilmott, John F Thompson, Graham J Mann, Georgina V Long, Richard A Scolyer, Mark P Molloy
BACKGROUND: Genotyping of melanomas is used to identify patients for treatment with BRAF and MEK inhibitors, but clinical responses are highly variable. This study investigated the utility of protein expression phenotyping to provide an integrated assessment of gene expression programs in BRAF/NRAS melanoma which would be useful for prognosis and may predict response to MEK inhibition. METHODS: Mass spectrometry profiling of early passage cell lines established from Stage III cutaneous melanomas was conducted...
August 17, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30116024/a-prospective-phase-ii-study-of-pre-operative-chemotherapy-then-short-course-radiotherapy-for-high-risk-rectal-cancer-copernicus
#3
Simon Gollins, Nicholas West, David Sebag-Montefiore, Shabbir Susnerwala, Stephen Falk, Nick Brown, Mark Saunders, Philip Quirke, Ruby Ray, Philip Parsons, Gareth Griffiths, Tim Maughan, Richard Adams, Chris Hurt
BACKGROUND: Neoadjuvant chemotherapy (NAC) allows earlier treatment of rectal cancer micro-metastases but is not standard of care. There are currently no biomarkers predicting long-term progression-free survival (PFS) benefit from NAC. PATIENTS AND METHODS: In this single arm phase II trial, patients with non-metastatic magnetic resonance imaging (MRI)-defined operable rectal adenocarcinoma at high risk of post-operative metastatic recurrence, received 8 weeks of oxaliplatin/fluorouracil NAC then short-course preoperative radiotherapy (SCPRT) before immediate surgery...
August 15, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30111871/brca1-and-brca2-mrna-expression-prove-to-be-of-clinical-impact-in-ovarian-cancer
#4
Irina Tsibulak, Verena Wieser, Christine Degasper, Giridhar Shivalingaiah, Sören Wenzel, Susanne Sprung, Sigurd F Lax, Christian Marth, Heidelinde Fiegl, Alain G Zeimet
BACKGROUND: Mutations in BRCA1 and BRCA2 are associated with better survival in ovarian cancer (OC) patients due to a better response to platinum-based chemotherapy. However, the impact of the BRCA1/2 mRNA-expression is not well characterized in OC. PATIENTS AND METHODS: We investigated BRCA1/2 mRNA-expression in 12 non-neoplastic fallopian tubes and 201 epithelial OCs in relation to their clinical characteristics. RESULTS: We found higher BRCA1/2 mRNA-expression in OCs compared to controls (P = 0...
August 15, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30111870/cigarette-smoking-and-thyroid-cancer-risk-a-cohort-study
#5
Ara Cho, Yoosoo Chang, Jiin Ahn, Hocheol Shin, Seungho Ryu
BACKGROUND: We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS: We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years. RESULTS: During 511,052.9 person-years of follow-up, 1,250 participants developed thyroid cancer. In men, we observed a dose-dependent inverse association between current smoking, pack-years, and thyroid cancer...
August 15, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30108294/cancer-mortality-and-incidence-following-external-occupational-radiation-exposure-an-update-of-the-3rd-analysis-of-the-uk-national-registry-for-radiation-workers
#6
Richard G E Haylock, Michael Gillies, Nezahat Hunter, Wei Zhang, Mary Phillipson
BACKGROUND: This study provides direct evidence of cancer risk from low dose and dose rate occupational external radiation exposures. METHODS: Cancer mortality and incidence were studied in relation to external radiation exposure in the National Registry for Radiation Workers. A cohort of 167,003 workers followed for an average of 32 years was analysed using Poisson regression methods. RESULTS: Mortality and incidence risks were significantly raised for the group of all malignant neoplasms excluding leukaemia (ERR/Sv mortality = 0...
August 15, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30108293/the-growing-importance-of-radiation-worker-studies
#7
EDITORIAL
Richard Wakeford
Large radiation worker studies have the potential to provide precise risk estimates for protracted exposure to low-level ionising radiation. Recent worker studies have reported statistically discernible dose-related increased risks of cancer; however, results must be interpreted with care, and occupational radiation doses need to be treated with particular attention.
August 15, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30108292/persistent-inequalities-in-unplanned-hospitalisation-among-colon-cancer-patients-across-critical-phases-of-their-care-pathway-england-2011-13
#8
Camille Maringe, Bernard Rachet, Georgios Lyratzopoulos, Francisco Javier Rubio
BACKGROUND: Reducing hospital emergency admissions is a key target for all modern health systems. METHODS: We analysed colon cancer patients diagnosed in 2011-13 in England. We screened their individual Hospital Episode Statistics records in the 90 days pre-diagnosis, the 90 days post-diagnosis, and the 90 days pre-death (in the year following diagnosis), for the occurrence of hospital emergency admissions (HEAs). RESULTS: Between a quarter and two thirds of patients experience HEA in the three 90-day periods examined: pre-diagnosis, post-diagnosis and before death...
August 15, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30082686/mir-532-5p-suppresses-renal-cancer-cell-proliferation-by-disrupting-the-ets1-mediated-positive-feedback-loop-with-the-kras-nap1l1-p-erk-axis
#9
Wei Zhai, Junjie Ma, Rujian Zhu, Chen Xu, Jin Zhang, Yonghui Chen, Zhiguo Chen, Dongkui Gong, Jiayi Zheng, Chen Chen, Saiyang Li, Butang Li, Yiran Huang, Wei Xue, Junhua Zheng
BACKGROUND: Despite the fact that miRNAs play pivotal roles in various human malignancies, their molecular mechanisms influencing RCC are poorly understood. METHODS: The expression of miRNAs from RCC and paired normal renal specimens was analysed by a combined computational and experimental approach using two published datasets and qRT-PCR assays. The functional role of these miRNAs was further identified by overexpression and inhibition assays in vivo and in vitro...
August 7, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30078843/identification-of-beta-arrestin-1-as-a-diagnostic-biomarker-in-lung-cancer
#10
Victoria El-Khoury, Mélanie Béland, Anna Schritz, Sang-Yoon Kim, Petr V Nazarov, Louis Gaboury, Katriina Sertamo, François Bernardin, Roxane Batutu, Laurent Antunes, Catherine W Bennett, François Faÿs, Guy Berchem, Yeoun Jin Kim
BACKGROUND: Distinguishing lung adenocarcinoma (ADC) from squamous cell carcinoma (SCC) has a tremendous therapeutic implication. Sometimes, the commonly used immunohistochemistry (IHC) markers fail to discriminate between them, urging for the identification of new diagnostic biomarkers. METHODS: We performed IHC on tissue microarrays from two cohorts of lung cancer patients to analyse the expression of beta-arrestin-1, beta-arrestin-2 and clinically used diagnostic markers in ADC and SCC samples...
August 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30072745/phase-iii-study-of-cisplatin-with-or-without-s-1-in-patients-with-stage-ivb-recurrent-or-persistent-cervical-cancer
#11
Yoichi Aoki, Kazunori Ochiai, Soyi Lim, Daisuke Aoki, Shoji Kamiura, Hao Lin, Noriyuki Katsumata, Soon-Do Cha, Jae-Hoon Kim, Byoung-Gie Kim, Yasuyuki Hirashima, Keiichi Fujiwara, Young-Tak Kim, Seok Mo Kim, Hyun Hoon Chung, Ting-Chang Chang, Toshiharu Kamura, Ken Takizawa, Masahiro Takeuchi, Soon-Beom Kang
BACKGROUND: This open-label phase III trial evaluated efficacy and safety of S-1 plus cisplatin vs. cisplatin alone as first-line chemotherapy in patients with stage IVB, recurrent, or persistent cervical cancer. METHODS: Patients were randomised (1:1) to S-1 plus cisplatin (study group) or cisplatin alone (control group). In each cycle, cisplatin 50 mg/m2 was administered on Day 1 in both groups. S-1 was administered orally at 80-120 mg daily on Days 1-14 of a 21-day cycle in the study group...
August 3, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30072744/serial-mutational-tracking-in-surgically-resected-locally-advanced-colorectal-cancer-with-neoadjuvant-chemotherapy
#12
Keishi Sugimachi, Shotaro Sakimura, Shotaro Kuramitsu, Hidenari Hirata, Atsushi Niida, Tomohiro Iguchi, Hidetoshi Eguchi, Takaaki Masuda, Masaru Morita, Yasushi Toh, Yoshihiko Maehara, Yutaka Suzuki, Koshi Mimori
BACKGROUND: We aim to investigate the utility of serial gene mutation tracking for locally advanced CRC in those who underwent curative resection following neoadjuvant chemotherapy. METHODS: We prospectively collected 10 locally advanced CRC cases for which curative resection was performed following preoperative neoadjuvant chemotherapy. Tissues from the primary tumour, distant metastatic tumours, and blood plasma were obtained during serial treatment. Comprehensive mutation analysis of 47 cancer-associated genes was performed using a pre-designed gene panel and next-generation sequencing...
August 3, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30065256/detection-of-circulating-tumour-cell-clusters-in-human-glioblastoma
#13
Ilona Krol, Francesc Castro-Giner, Martina Maurer, Sofia Gkountela, Barbara Maria Szczerba, Ramona Scherrer, Niamh Coleman, Suzanne Carreira, Felix Bachmann, Stephanie Anderson, Marc Engelhardt, Heidi Lane, Thomas Ronald Jeffry Evans, Ruth Plummer, Rebecca Kristeleit, Juanita Lopez, Nicola Aceto
Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it is unclear whether multicellular CTC clusters are generated in this disease and whether they can bypass the physical hurdle of the blood-brain barrier.  Here, we assessed CTC presence and composition at multiple time points in 13 patients with progressing GBM during an open-label phase 1/2a study with the microtubule inhibitor BAL101553...
August 1, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30065255/the-value-of-using-the-faecal-immunochemical-test-in-general-practice-on-patients-presenting-with-non-alarm-symptoms-of-colorectal-cancer
#14
Jakob Søgaard Juul, Nete Hornung, Berit Andersen, Søren Laurberg, Frede Olesen, Peter Vedsted
BACKGROUND: Around 50% of individuals with colorectal cancer (CRC) initially present with non-alarm symptoms. METHODS: We investigated the value of using the faecal immunochemical test (FIT) in the diagnostic process of CRC and other serious bowel disease in individuals presenting with non-alarm symptoms in general practice. The study was conducted in the Central Denmark Region from 1 September 2015 to 30 August 2016. The FIT was used as a rule-in test on patients aged ≥30 years with non-alarm symptoms of CRC...
August 1, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30065254/cardiovascular-disease-incidence-after-internal-mammary-chain-irradiation-and-anthracycline-based-chemotherapy-for-breast-cancer
#15
Naomi B Boekel, Judy N Jacobse, Michael Schaapveld, Maartje J Hooning, Jourik A Gietema, Frances K Duane, Carolyn W Taylor, Sarah C Darby, Michael Hauptmann, Caroline M Seynaeve, Margreet H A Baaijens, Gabe S Sonke, Emiel J T Rutgers, Nicola S Russell, Berthe M P Aleman, Flora E van Leeuwen
BACKGROUND: Improved breast cancer (BC) survival and evidence showing beneficial effects of internal mammary chain (IMC) irradiation underscore the importance of studying late cardiovascular effects of BC treatment. METHODS: We assessed cardiovascular disease (CVD) incidence in 14,645 Dutch BC patients aged <62 years, treated during 1970-2009. Analyses included proportional hazards models and general population comparisons. RESULTS: CVD rate-ratio for left-versus-right breast irradiation without IMC was 1...
August 1, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30061587/practice-changing-radiation-therapy-trials-for-the-treatment-of-cancer-where-are-we-150-years-after-the-birth-of-marie-curie
#16
REVIEW
Mareike K Thompson, Philip Poortmans, Anthony J Chalmers, Corinne Faivre-Finn, Emma Hall, Robert A Huddart, Yolande Lievens, David Sebag-Montefiore, Charlotte E Coles
As we mark 150 years since the birth of Marie Curie, we reflect on the global advances made in radiation oncology and the current status of radiation therapy (RT) research. Large-scale international RT clinical trials have been fundamental in driving evidence-based change and have served to improve cancer management and to reduce side effects. Radiation therapy trials have also improved practice by increasing quality assurance and consistency in treatment protocols across multiple centres. This review summarises some of the key RT practice-changing clinical trials over the last two decades, in four common cancer sites for which RT is a crucial component of curative treatment: breast, lung, urological and lower gastro-intestinal cancer...
July 31, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30061586/trastuzumab-and-paclitaxel-in-patients-with-egfr-mutated-nsclc-that-express-her2-after-progression-on-egfr-tki-treatment
#17
Adrianus J de Langen, M Jebbink, Sayed M S Hashemi, Justine L Kuiper, J de Bruin-Visser, Kim Monkhorst, Erik Thunnissen, Egbert F Smit
BACKGROUND: HER2 expression and amplification are observed in ~15% of tumour biopsies from patients with a sensitising EGFR mutation who develop EGFR TKI resistance. It is unknown whether HER2 targeting in this setting can result in tumour responses. METHODS: A single arm phase II study was performed to study the safety and efficacy of trastuzumab and paclitaxel treatment in patients with a sensitising EGFR mutation who show HER2 expression in a tumour biopsy (IHC ≥ 1) after progression on EGFR TKI treatment...
July 31, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30061585/comment-on-anthropometric-measurements-and-survival-after-prostate-cancer-diagnosis
#18
LETTER
Luigino Dal Maso, Antonella Zucchetto, Carmen Stocco, Diego Serraino, Jerry Polesel
No abstract text is available yet for this article.
July 31, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30061584/reply-to-comment-on-anthropometric-measurements-and-survival-after-prostate-cancer-diagnosis
#19
LETTER
Megan S Farris, Kerry S Courneya, Karen A Kopciuk, S Elizabeth McGregor, Christine M Friedenreich
No abstract text is available yet for this article.
July 31, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/30057408/treatment-and-survival-of-rectal-cancer-patients-over-the-age-of-80-years-a-eurecca-international-comparison
#20
Yvette H M Claassen, Nina C A Vermeer, Lene H Iversen, Elizabeth van Eycken, Marianne G Guren, Pawel Mroczkowski, Anna Martling, Antonio Codina Cazador, Robert Johansson, Tamara Vandendael, Arne Wibe, Bjorn Moller, Hans Lippert, Harm J T Rutten, Johanneke E A Portielje, Gerrit J Liefers, Fabian A Holman, Cornelis J H van de Velde, Esther Bastiaannet
BACKGROUND: The optimal treatment strategy for older rectal cancer patients remains unclear. The current study aimed to compare treatment and survival of rectal cancer patients aged 80+. METHODS: Patients of ≥80 years diagnosed with rectal cancer between 2001 and 2010 were included. Population-based cohorts from Belgium (BE), Denmark (DK), the Netherlands (NL), Norway (NO) and Sweden (SE) were compared side by side for neighbouring countries on treatment strategy and 5-year relative survival (RS), adjusted for sex and age...
July 30, 2018: British Journal of Cancer
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