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British Journal of Cancer

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https://www.readbyqxmd.com/read/29930252/correction-genistein-downregulates-onco-mir-1260b-and-upregulates-sfrp1-and-smad4-via-demethylation-and-histone-modification-in-prostate-cancer-cells
#1
H Hirata, Y Hinoda, V Shahryari, G Deng, Y Tanaka, Z L Tabatabai, R Dahiya
The authors report that there is a mistake in the representative picture of Fig. 4D (top row: PC3-miR1260b inh-0h) in the original version. The correct version of Fig. 4 with the original pictures for both PC3 miR-NC inh-0h and PC3-miR1260b inh-0h are provided below.
June 22, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29930251/treponema-denticola-chymotrypsin-like-protease-as-associated-with-hpv-negative-oropharyngeal-squamous-cell-carcinoma
#2
Anna Kaisa Kylmä, Lauri Jouhi, Dyah Listyarifah, Hesham Mohamed, Antti Mäkitie, Satu Maria Remes, Caj Haglund, Timo Atula, Mikko T Nieminen, Timo Sorsa, Jaana Hagström
BACKGROUND: An opportunistic oral pathogen, Treponema denticola (Td), has been linked to orodigestive carcinogenesis, but its role in oropharyngeal squamous cell carcinoma (OPSCC) has remained open. We evaluated the presence of Td chymotrypsin-like protease (Td-CTLP) in a series of 201 unselected consecutive OPSCC patients, and the relation of the Td-CTLP to human papillomavirus (HPV) status, to expression of toll-like receptors (TLR) 5, 7, and 9, and to clinical parameters and patient outcome...
June 22, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29925934/circulating-biomarkers-during-treatment-in-patients-with-advanced-biliary-tract-cancer-receiving-cediranib-in-the-uk-abc-03-trial
#3
Alison C Backen, Andre Lopes, Harpreet Wasan, Daniel H Palmer, Marian Duggan, David Cunningham, Alan Anthoney, Pippa G Corrie, Srinivasan Madhusudan, Anthony Maraveyas, Paul J Ross, Justin S Waters, William P Steward, Charlotte Rees, Mairéad G McNamara, Sandy Beare, John A Bridgewater, Caroline Dive, Juan W Valle
BACKGROUND: Advanced biliary tract cancer (ABC) has a poor prognosis. Cediranib, in addition to cisplatin/gemcitabine [CisGem], improved the response rate, but did not improve the progression-free survival (PFS) in the ABC-03 study. Minimally invasive biomarkers predictive of cediranib benefit may improve patient outcomes. METHODS: Changes in 15 circulating plasma angiogenesis or inflammatory-related proteins and cytokeratin-18 (CK18), measured at baseline and during therapy until disease progression, were correlated with overall survival (OS) using time-varying covariate Cox models (TVC)...
June 21, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29925933/validation-of-the-ibis-breast-cancer-risk-evaluator-for-women-with-lobular-carcinoma-in-situ
#4
Louisa Lisa Lo, Roger Laughlin Milne, Yuyan Liao, Jack Cuzick, Mary Beth Terry, Kelly-Anne Phillips
BACKGROUND: Management advice for women with lobular carcinoma in situ (LCIS) is hampered by the lack of accurate personalised risk estimates for subsequent invasive breast cancer (BC). Prospective validation of the only tool that estimates individual BC risk for a woman with LCIS, the International Breast Cancer Intervention Study Risk Evaluation Tool (IBIS-RET), is lacking. METHODS: Using population-based cancer registry data for 732 women with LCIS, the calibration and discrimination accuracy of IBIS-RET Version 7...
June 21, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29921949/expression-patterns-of-programmed-death-ligand-1-correlate-with-different-microenvironments-and-patient-prognosis-in-hepatocellular-carcinoma
#5
Chao-Qun Liu, Jing Xu, Zhong-Guo Zhou, Li-Lian Jin, Xing-Juan Yu, Gang Xiao, Jie Lin, Shi-Mei Zhuang, Yao-Jun Zhang, Limin Zheng
BACKGROUND: Recent clinical studies have suggested that programmed death ligand 1 (PD-L1) expression in a tumour could be a potential biomarker for PD-L1/PD-1 blockade therapies. METHODS: To better characterise PD-L1 expression in hepatocellular carcinoma (HCC), we analysed its expression patterns in 453 HCC patients by double staining for CD68 and PD-L1 using the Tyramide Signal Amplification Systems combined with immunohistochemistry. We also investigated its correlation with clinical features, prognosis and immune status...
June 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29921948/increased-sensitivity-to-apoptosis-upon-endoplasmic-reticulum-stress-induced-activation-of-the-unfolded-protein-response-in-chemotherapy-resistant-malignant-pleural-mesothelioma
#6
Duo Xu, Shun-Qing Liang, Haitang Yang, Ursina Lüthi, Carsten Riether, Sabina Berezowska, Thomas M Marti, Sean R R Hall, Rémy Bruggmann, Gregor J Kocher, Ralph A Schmid, Ren-Wang Peng
BACKGROUND: Standard treatment for advanced malignant pleural mesothelioma (MPM) is a cisplatin/pemetrexed (MTA) regimen; however, this is confronted by drug resistance. Proteotoxic stress in the endoplasmic reticulum (ER) is a hallmark of cancer and some rely on this stress signalling in response to cytotoxic chemotherapeutics. We hypothesise that ER stress and the adaptive unfolded protein response (UPR) play a role in chemotherapy resistance of MPM. METHODS: In vitro three-dimensional (3D) and ex vivo organotypic culture were used to enrich a chemotherapy-resistant population and recapitulate an in vivo MPM microenvironment, respectively...
June 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29915322/rare-germline-variants-in-dna-repair-genes-and-the-angiogenesis-pathway-predispose-prostate-cancer-patients-to-develop-metastatic-disease
#7
Martina Mijuskovic, Edward J Saunders, Daniel A Leongamornlert, Sarah Wakerell, Ian Whitmore, Tokhir Dadaev, Clara Cieza-Borrella, Koveela Govindasami, Mark N Brook, Christopher A Haiman, David V Conti, Rosalind A Eeles, Zsofia Kote-Jarai
BACKGROUND: Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes. METHODS: We sequenced germline whole exomes from 139 aggressive (metastatic, age of diagnosis < 60) and 141 non-aggressive (low clinical grade, age of diagnosis ≥60) PrCa cases. We conducted rare variant association analyses at gene and gene set levels using SKAT and Bayesian risk index techniques...
June 19, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29899395/addition-of-intraperitoneal-cisplatin-and-etoposide-to-first-line-chemotherapy-for-advanced-ovarian-cancer-a-randomised-phase-2-trial
#8
Tingyan Shi, Rong Jiang, Jinjin Yu, Huijuan Yang, Dongsheng Tu, Zhiyuan Dai, Yang Shen, Yuqin Zhang, Xi Cheng, Huixun Jia, Ruiqin Tu, Huaying Wang, Jie Tang, Yuting Luan, Shumo Cai, Rongyu Zang
BACKGROUND: We assessed the efficacy of adding intraperitoneal (IP) chemotherapy to standard first-line intravenous (IV) chemotherapy in epithelial ovarian cancer (EOC) patients. METHODS: Patients with stage IIIC-IV EOC who underwent optimal debulking surgery were randomly assigned to four cycles of weekly IP chemotherapy with cisplatin (50 mg/m2 ) and etoposide (100 mg/m2 ) followed by six cycles of IV chemotherapy every 3 weeks (IP/IV arm), or were administered IV chemotherapy alone (IV arm)...
June 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29899394/g1p3-ifi6-a-mitochondrial-localised-antiapoptotic-protein-promotes-metastatic-potential-of-breast-cancer-cells-through-mtros
#9
Venugopalan Cheriyath, Jaspreet Kaur, Anne Davenport, Ashjan Khalel, Nobel Chowdhury, Lalitha Gaddipati
BACKGROUND: Redox deregulations are ubiquitous in cancer cells. However, the role of mitochondrial redox deregulation in metastasis remains unclear. In breast cancer, upregulation of mitochondrial antiapoptotic protein G1P3 (IFI6) was associated with poor distance metastasis-free survival (DMFS). Therefore, we tested the hypothesis that G1P3-induced mitochondrial redox deregulation confers metastatic potentials in breast cancer cells. METHODS: Cell migration and invasion assays; confocal and immunofluorescence microscopy; and Illumina HumanHT-12 BeadChip to assess gene expression...
June 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29899393/transcriptomic-immune-profiling-of-ovarian-cancers-in-paraneoplastic-cerebellar-degeneration-associated-with-anti-yo-antibodies
#10
Clément Vialatte de Pémille, Giulia Berzero, Mathilde Small, Dimitri Psimaras, Marine Giry, Maïlys Daniau, Marc Sanson, Jean-Yves Delattre, Jérôme Honnorat, Virginie Desestret, Agusti Alentorn
BACKGROUND: Paraneoplastic neurological syndromes are rare conditions where an autoimmune reaction against the nervous system appears in patients suffering from a tumour, but not linked to the spreading of the tumour. A break in the immune tolerance is thought to be the trigger. METHODS: The transcriptomic profile of 12 ovarian tumours (OT) from patients suffering from paraneoplastic cerebellar degeneration (PCD) linked to anti-Yo antibodies (anti-Yo PCD OT) was compared with 733 ovarian tumours (OT control) from different public databases using linear model analysis...
June 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29899392/tgf%C3%AE-shuts-the-door-on-t-cells
#11
EDITORIAL
Tobias Bald, Mark J Smyth
T cell exclusion from cancers is a major problem for a proportion of patients suffering poor outcomes. Two papers recently published in Nature highlight the negative role of cancer associated fibroblast TGFβ. These studies indicate that TGFβ enables T cell exclusion in a proportion of colorectal and urothelial cancers, and in the latter disease may reduce their response to anti-PD-L1 immunotherapy.
June 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29899391/heterogeneous-relationships-of-squamous-and-basal-cell-carcinomas-of-the-skin-with-smoking-the-uk-million-women-study-and-meta-analysis-of-prospective-studies
#12
Kirstin Pirie, Valerie Beral, Alicia K Heath, Jane Green, Gillian K Reeves, Richard Peto, Penelope McBride, Catherine M Olsen, Adèle C Green
INTRODUCTION: Published findings on the associations between smoking and the incidence of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are inconsistent. We aimed to generate prospective evidence on these relationships overall and by anatomical site. METHODS: We followed 1,223,626 women without prior cancer by electronic linkage to national cancer registration data. Questionnaire information about smoking and other factors was recorded at recruitment (1996-2001) and every 3-5 years subsequently...
June 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29899390/correction-protein-biomarkers-predictive-for-response-to-anti-egfr-treatment-in-ras-wild-type-metastatic-colorectal-carcinoma
#13
Astrid Lièvre, Bérèngere Ouine, Jim Canet, Aurélie Cartier, Yael Amar, Wulfran Cacheux, Odette Mariani, Rosine Guimbaud, Janick Selves, Thierry Lecomte, Serge Guyetant, Ivan Bieche, Frédérique Berger, Leanne de Koning
Supplementary Table 1 and the Supplementary Figure legends were not included when this manuscript was first published. The files are now available here.
June 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29895939/midlife-weight-gain-is-a-risk-factor-for-obesity-related-cancer
#14
Susan Chadid, Martha R Singer, Bernard E Kreger, M Loring Bradlee, Lynn L Moore
BACKGROUND: Overweight and diabetes are known cancer risk factors. This study examines independent and combined effects of weight gain and metabolic dysfunction during middle-adult years on obesity-related cancer risk. METHODS: Subjects (n = 3850) aged 45-69 years at exams 3-5 in the Framingham Offspring Study were classified according to current and prior (~14 years earlier) weight status, interim weight change and prevalent metabolic dysfunction. Cancer risk among subjects who were overweight at baseline and remained overweight, as well as those who became overweight during follow-up, was compared with risk among normal-weight individuals...
June 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29891937/evaluation-of-efficacy-and-safety-of-sorafenib-in-kidney-cancer-patients-aged-75-years-and-older-a-propensity-score-matched-analysis
#15
Katsunori Tatsugami, Mototsugu Oya, Koki Kabu, Hideyuki Akaza
BACKGROUND: The average age of patients diagnosed with renal cell carcinoma (RCC) is increasing, but a limited number of reports have described therapy of tyrosine kinase inhibitor for elderly RCC patients. Hence, we analysed the efficacy and safety of sorafenib in elderly patients aged ≥75 years with advanced RCC. METHODS: Data were extracted from <75-year-old and ≥75-year-old patient groups, matching those demographics considered to affect prognosis. Differences in patients' characteristics, dose modification, adverse events, tumour response, progression-free survival, and renal function (glomerular filtration) were evaluated between the groups...
June 12, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29880907/prognostic-value-of-androgen-receptor-and-foxa1-co-expression-in-non-metastatic-triple-negative-breast-cancer-and-correlation-with-other-biomarkers
#16
Séverine Guiu, Caroline Mollevi, Céline Charon-Barra, Florence Boissière, Evelyne Crapez, Elodie Chartron, Pierre-Jean Lamy, Marian Gutowski, Céline Bourgier, Gilles Romieu, Joelle Simony-Lafontaine, William Jacot
BACKGROUND: In luminal androgen receptor (AR) tumours, FOXA1 may direct AR to sites occupied by ER in luminal tumours, thus stimulating proliferation. METHODS: AR and FOXA1 expression were evaluated by immunohistochemistry in 333 non-metastatic triple-negative breast cancers (TNBC). Positivity threshold was set at ≥ 1% staining. Lymphocytic infiltration, PD-L1expression, PIK3CA mutations, PTEN defects and BRCA1 promoter methylation were assessed. RESULTS: AR + /FOXA1 + tumours (42...
June 8, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29875471/variation-in-treatment-and-survival-of-older-patients-with-non-metastatic-breast-cancer-in-five-european-countries-a-population-based-cohort-study-from-the-eurecca-breast-cancer-group
#17
Marloes G M Derks, Esther Bastiaannet, Mandy Kiderlen, Denise E Hilling, Petra G Boelens, Paul M Walsh, Elizabeth van Eycken, Sabine Siesling, John Broggio, Lynda Wyld, Maciej Trojanowski, Agnieszka Kolacinska, Justyna Chalubinska-Fendler, Ana Filipa Gonçalves, Tomasz Nowikiewicz, Wojciech Zegarski, Riccardo A Audisio, Gerrit-Jan Liefers, Johanneke E A Portielje, Cornelis J H van de Velde
BACKGROUND: Older patients are poorly represented in breast cancer research and guidelines do not provide evidence based recommendations for this specific group. We compared treatment strategies and survival outcomes between European countries and assessed whether variance in treatment patterns may be associated with variation in survival. METHODS: Population-based study including patients aged ≥ 70 with non-metastatic BC from cancer registries from the Netherlands, Belgium, Ireland, England and Greater Poland...
June 7, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29872151/prognostic-role-of-carcinoembryonic-antigen-and-carbohydrate-antigen-19-9-in-metastatic-colorectal-cancer-a-braf-mutant-subset-with-high-ca-19-9-level-and-poor-outcome
#18
Maria Thomsen, Eva Skovlund, Halfdan Sorbye, Nils Bolstad, Kjell Johannes Nustad, Bengt Glimelius, Per Pfeiffer, Elin H Kure, Julia S Johansen, Kjell Magne Tveit, Thoralf Christoffersen, Tormod Kyrre Guren
BACKGROUND: Mutation status of RAS and BRAF, as well as serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9), are biomarkers used in clinical management of patients with gastrointestinal cancers. This study aimed to examine the prognostic role of these biomarkers in a patient population that started first-line chemotherapy for unresectable metastatic colorectal cancer (mCRC) in the NORDIC-VII study. METHODS: CEA and CA 19-9 were measured in serum samples from 545 patients obtained before the start of chemotherapy...
June 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29872150/adiposity-and-risks-of-colorectal-and-small-intestine-cancer-in-chinese-adults-a-prospective-study-of-0-5-million-people
#19
Yuanjie Pang, Christiana Kartsonaki, Yu Guo, Yiping Chen, Ling Yang, Zheng Bian, Fiona Bragg, Iona Y Millwood, Enke Mao, Yilei Li, Liya Shi, Junshi Chen, Liming Li, Michael V Holmes, Zhengming Chen
BACKGROUND: Uncertainty remains about the associations of adiposity with intestinal cancer in China and by its anatomical subtype. METHODS: The prospective China Kadoorie Biobank recorded 3024 incident cases of colorectal (CRC) and 143 cases of small intestine (SIC) cancer during a 10-year follow-up among 509 568 participants without prior cancer at baseline. Cox regression was used to estimate adjusted hazard ratios (HRs) for specific cancers associated with adiposity...
June 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29872149/agrin-has-a-pathological-role-in-the-progression-of-oral-cancer
#20
César Rivera, Flávia Silva Zandonadi, Celeste Sánchez-Romero, Ciro Dantas Soares, Daniela Campos Granato, Wilfredo Alejandro González-Arriagada, Adriana Franco Paes Leme
BACKGROUND: The extracellular matrix modulates the hallmarks of cancer. Here we examined the role of agrin-a member of this matrix-in progression of oral squamous cell carcinoma (OSCC). METHODS: We evaluated the immunohistochemical expression of agrin in OSCC and dysplasias. Benign lesions were used as control. In subsequent experiments, we investigated whether the silencing of agrin interferes with tumour expansion both in vitro as well as in vivo. To gain insights into the role of agrin, we identified its protein network (interactome) using mass spectrometry-based proteomics and bioinformatics...
June 6, 2018: British Journal of Cancer
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