Xiaofang Zhao, Chenlong Yang, Xin Chen, Yu Sun, Weihai Liu, Qinggang Ge, Jun Yang
OBJECTIVE: Alpha-Synuclein (α-Syn), a presynaptic neuronal protein encoded by the SNCA gene, is involved in the pathogenesis of Parkinson's disease. Point mutations and multiplications of the α-Syn (A30P and A53T) are correlated with early-onset Parkinson's disease characterized by rapid progression and poor prognosis. Currently, the clinical identification of SNCA variants, especially disease-related A30P and A53T mutants, remains challenging and also time-consuming. This study has aimed to develop a novel label-free detection method for distinguishing the SNCA mutants using transmission terahertz (THz) time-domain spectroscopy...
April 13, 2024: Biophysical Journal