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Acta Cardiologica

Raphaëlle-Ashley Guerbaai, Indrajeet Mahata, Sylvestre Maréchaux, Thierry H Le Jemtel, Pierre-Vladimir Ennezat
Ticagrelor is a reversible P2Y12 receptor antagonist that is more potent than clopidogrel. When used in combination with aspirin, it reduces cardiovascular events in patients with acute coronary syndrome. However, unbiased review of 5 randomised controlled trials indicates that although statistically significant, the clinical superiority of ticagrelor over clopidogrel is modest. Thus, identification of patients who benefit the most from ticagrelor is a priority. Besides bleeding issues, ticagrelor can frequently cause bouts of dyspnoea, which requires ticagrelor replacement by another P2Y12 receptor antagonist, with a loading dose...
May 7, 2018: Acta Cardiologica
Philippe B Bertrand, Melanie Habran, Karlijn Kenis, Julie Lecomte, Linde Moonen, Didier Stroobants, Edouard Benit
BACKGROUND: Percutaneous left atrial appendage occlusion (LAAO) is an alternative to anticoagulation in atrial fibrillation patients at high bleeding risk. Dual antiplatelet therapy (DAPT) is generally recommended in the months following the procedure to prevent thrombotic complications. The aim of this study was to evaluate the safety and efficacy of DAPT after LAAO in a single-centre population of high bleeding risk patients. METHODS: All patients who received DAPT after LAAO using the Amplatzer Cardiac Plug at Jessa Hospital (Hasselt, BE) between February 2011 and October 2016 were included...
April 1, 2018: Acta Cardiologica
Frederik H Verbrugge, Pieter Martens, Koen Ameloot, Veerle Haemels, Joris Penders, Matthias Dupont, W H Wilson Tang, Walter Droogné, Wilfried Mullens
BACKGROUND: Signs and symptoms of volume overload are the most frequent reason for hospital admission in acute heart failure (AHF). Diuretics are mainstay treatment, but their optimal type and dose regimen remain unclear, especially in patients with cardiorenal syndrome. METHODS: This prospective study aimed to include 80 AHF patients with volume overload and cardiorenal syndrome. Through a 2 × 2 factorial design, patients were randomised towards (1) combinational treatment with acetazolamide and low-dose loop diuretics versus high-dose loop diuretics; and (2) open-label oral spironolactone 25 mg OD given upfront versus at discharge...
March 27, 2018: Acta Cardiologica
Frederic De Roeck, Benjamin Scott, Stefan Verheye, Paul Vermeersch
No abstract text is available yet for this article.
March 23, 2018: Acta Cardiologica
Alessandro Menotti, Paolo Emilio Puddu, Hanna Tolonen, Hisashi Adachi, Anthony Kafatos, Daan Kromhout
OBJECTIVES: To explore age at death (AD) for major cardiovascular diseases (CVD) and their risk factors in originally middle-aged men followed nearly to extinction in the Seven Countries Study. MATERIALS AND METHODS: Thirteen cohorts of men aged 40-59 years (N = 10,628) in seven countries (USA, Finland, the Netherlands, Italy, Serbia, Greece, Japan) were enrolled in late 1950s and early 1960s and were followed 45 years for mortality. AD was computed for coronary heart disease (CHD), stroke (STR), heart disease of uncertain aetiology (HDUE) and for all-causes...
March 23, 2018: Acta Cardiologica
Anne-Sophie Valschaerts, Michaël Dupont, Stéphanie Seldrum
No abstract text is available yet for this article.
March 23, 2018: Acta Cardiologica
Keir McCutcheon, Andreas S Triantafyllis, Thomas Marynissen, Tom Adriaenssens, Johan Bennett, Christophe Dubois, Peter R Sinnaeve, Walter Desmet
BACKGROUND: The optimal therapeutic strategy for ST-segment elevation myocardial infarction (STEMI) patients found to have multi-vessel disease (MVD) is controversial but recent data support complete revascularisation (CR). Whether CR should be completed during the index admission or during a second staged admission remains unclear. Our main objective was to measure rates of major adverse cardiovascular events (MACEs) during the waiting period in STEMI patients selected for staged revascularisation (SR), in order to determine the safety of delaying CR...
March 21, 2018: Acta Cardiologica
Catherine Paris, Raluca E Dulgheru
No abstract text is available yet for this article.
March 20, 2018: Acta Cardiologica
Thomas Castelein, Frank Van Praet, Kris Van Der Steen, Guy Van Camp
No abstract text is available yet for this article.
March 20, 2018: Acta Cardiologica
Salma I Patel, Michael J Ackerman, Fadi E Shamoun, Jeffrey B Geske, Steve R Ommen, William T Love, Stephen S Cha, Johan M Bos, Steven J Lester
INTRODUCTION: Risk assessment for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) remains complex. The goal of this study was to assess electrocardiogram (ECG)-derived risk factors on SCD in a large HCM population Methods: Retrospective review of adults with HCM evaluated at Mayo Clinic, Rochester, MN from 1 December 2002 to 31 December 2012 was performed. Data inclusive of ECG and 24-hour ambulatory Holter monitor were assessed. SCD events were documented by ventricular fibrillation (VF) noted on implantable cardioverter defibrillator (ICD), or appropriate VT or VF-terminating ICD shock...
March 7, 2018: Acta Cardiologica
Joseph Burns, Dharam Persaud-Sharma, Dollie Green
In the United States, hypertension is a significant medical problem that affects nearly 1 in 3 adults, causes thousands of deaths annually, and costs the nation billions of dollars annually for medical management in terms of hospitalisations, lost wages, and pharmacotherapy. The management guidelines of hypertension have greatly varied between different healthcare organisations including the American College of Cardiology (ACC), the European Society of Cardiology (ESC) and the Joint National Committee (JNC-7, 8)...
March 5, 2018: Acta Cardiologica
Inês Silveira, Maria Trêpa, Patricia Rodrigues, Filomena Oliveira
No abstract text is available yet for this article.
February 28, 2018: Acta Cardiologica
Stepan Jerabek, Tomas Kovarnik
BACKGROUND: The only indication for coronary revascularization is elimination of ischaemia. Invasive hemodynamic methods (fractional flow reserve - FFR and instantaneous wave-free ratio (iFR) are superior to coronary angiography in detection of lesions causing myocardial ischaemia. Current European guidelines for myocardial revascularization recommend using of FFR for detection of functional assessment of lesions severity in category IA and number of these procedures increases. However, routine usage of these methods requires knowledge of technical requirements and limitations...
February 27, 2018: Acta Cardiologica
Hiten Patel, Upamanyu Rampal, Yamini Sundermurthy, Priyank Shah, Fayez Shamoon, Satish Tiyyagura
No abstract text is available yet for this article.
April 2018: Acta Cardiologica
Adnan Kaya, Muhammed Keskin, Tolga Sinan Güvenç, Mustafa Adem Tatlısu, Osman Kayapınar
BACKGROUND: The prognostic value of thrombolysis in myocardial infarction (TIMI) risk index (TRI) has been reported in patients with coronary artery disease. In this study, we evaluated the additional prognostic value of blood urea nitrogen (BUN) level to the TRI in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: We evaluated the in-hospital and long-term (3-year) prognostic value of modified TRI (mTRI) in patients with STEMI. The mTRI is calculated using the following equation; mTRI = (TRI × BUN)/10...
February 23, 2018: Acta Cardiologica
Ali Rıza Akyuz, Levent Korkmaz, Ufuk Sayar, İlker Mataracı
No abstract text is available yet for this article.
February 23, 2018: Acta Cardiologica
Vinai C Bhagirath, Bernard Cosyns, John W Eikelboom
The 2016 European Society of Cardiology Guidelines recommend non-vitamin K antagonist oral anticoagulants (NOACs) in preference to vitamin K antagonists (VKA) for stroke prevention in atrial fibrillation. A recent report from the Belgian Healthcare Knowledge Centre (KCE) raised concerns about the results of the phase 3 randomised trials that led to the approval of the NOACs for this indication and concluded that NOACs should only be used for patients who fail or cannot undergo treatment with a vitamin K antagonist because they cannot achieve stable INR values...
February 23, 2018: Acta Cardiologica
Georges H Mairesse, Jean-Benoit Le Polain de Waroux, Rik Willems, Willem Alvoet, Ivan Blankoff, Johan Vijgen, Thierry Verbeet
This report presents and discusses, on behalf of the Belgian College of Cardiology, the evolution of the peer review process in arrhythmology, focussing on pacemaker implantation. Data from the last 22 years are compared. The national annual increase in implants is around 1%, clinical patient characteristics remained stable over the years while dual chamber pacing was proportionally increasing. Analyses of the normalised sick sinus and complete atrioventricular block ratios revealed a quite homogenous practice between centres and patient district with the only exception of the two more crowded districts...
February 20, 2018: Acta Cardiologica
Delphine De Smedt, Johan De Sutter, Michel De Pauw, Hans Vandekerckhove, Jan Trouerbach, Guy De Backer, Anne-Marie Willems, Sofie Pardaens, Pieter Vervaet, Nancy Deweerdt, Dirk De Bacquer
OBJECTIVE: The aim of this study was to assess lifestyle behaviour as well as risk factor management across Belgian coronary patients who participated in the cross-sectional European Action on Secondary Prevention through Intervention to Reduce Events (EUROASPIRE) surveys. METHODS: Analyses are based on a series of coronary patients by combining data from the Belgian participants in the EUROASPIRE III (328 patients; in 2006-2007) and EUROASPIRE IV (343 patients; in 2012-2013) surveys...
February 19, 2018: Acta Cardiologica
Michel de Ceuninck, Philip Muyldermans, Stefaan van de Walle, Bernard Bergez, Rik Haspeslagh, Francis Stammen, Karl Dujardin
The radiation exposure in the cath lab of patients, cardiologists, and nurses was measured during three consecutive periods of 8 weeks. The first 8 weeks the baseline radiation exposure was obtained. In the second period standard incidences for coronarography and frame rate were changed, without compromising the image quality of the examination. In the third period, a pelvic shield covered the lower part of the patient. This pilot quality project demonstrates that further significant reduction in radiation exposure of 37% is possible for patients...
February 19, 2018: Acta Cardiologica
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