Yitao Liang, Yu Jiang, Lu Fang, Zhen Dai, Shanshan Zhang, Yue Zhou, Yu Cai, Dong Wang, Zhaoyang Wang, Xuesong Ye, Bo Liang
DNA methylation aberrations have a strong correlation with cancer in early detection, diagnosis, and prognosis, which make them possible candidate biomarkers. Electrochemical biosensors offer rapid protocols for detecting DNA methylation status with minimal pretreatment of samples. However, the inevitable presence of background current in the time domain, including electrochemical noise and variations, limits the detection performance of these biosensors, especially for low concentration analytes. Here, we propose an ultrasensitive frequency-domain electrochemical analysis strategy to effectively separate the weak signals from background current...
March 18, 2024: Analytical Biochemistry