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Analytica Chimica Acta

S Ansari, M Shahnawaze Ansari, S P Satsangee, R Jain
Ranolazine (RZ) is an anti-anginal drug with a distinct mechanism of action and widely employed in patients with chronic angina. Its measurement is essential in clinical environment to ensure adequate drug level and understand the redox mechanism which gives an idea of in-vivo fate of the drug. In view of this, an exemplary voltammetric approach is proposed here for determination of RZ utilizing glassy carbon electrode (GCE) fabricated with WO3 decorated graphene nanocomposite. The structural and morphological characterizations of modifier were made by employing XRD, FESEM, EDAX, HRTEM, XPS, Raman and FT-IR spectroscopy which revealed successful formation of the nanocomposite...
January 10, 2019: Analytica Chimica Acta
Qia Wang, Chun Yang, Qingui Yang, Shenghao Yu, Haipeng Yang
In 2009, Sreekumar found that sarcosine, as an effective biomarker, can be used to identify prostate cancer. However, it is difficult to detect sarcosine in urine or plasma because of its low concentration. In this work, we describe a simple strategy for the preparation of sarcosine biosensor based on platinum-loaded mesoporous nickel phosphonate (Pt/MNP) and subsequently apply it to detect sarcosine. Mesoporous structure could increase the active sites on the MNP surface, which makes the Pt/MNP have excellent electrochemical performance for detecting hydrogen peroxide, one of the enzymatic products, and the sarcosine biosensor exhibited a superior electrochemical performance...
January 10, 2019: Analytica Chimica Acta
D Barišić, V Tomišić, N Bregović
Knowledge regarding the acid-base behaviour in non-aqueous media has remained relatively scarce in spite of its importance for many aspects of chemistry. The research presented in this work fills some of particularly important gaps in the corresponding thermodynamic data. We report on a detailed study of acid-base properties of dihydrogen phosphate and acetate in aprotic organic solvents (acetonitrile, dimethyl sulfoxide, and dimethylformamide). It was found that several processes, i.e. protonation, homoassociation, and dimerisation play important roles in defining the basicity of these widely important anions...
January 10, 2019: Analytica Chimica Acta
A V Ivanova, E L Gerasimova, E R Gazizullina
For the first time, the dependence of a redox potential change during a reaction of peroxyl radical generation and their interaction with antioxidants was studied. A regular change of a potential is due to oxidation of an antioxidant by initiating peroxyl radicals accompanied by an electron transfer. An original direct method for determining induction periods, inhibition coefficients and an antiradical capacity using the potentiometric method is proposed. Using the proposed approach the induction periods and the inhibition coefficients of various OH, NH, SH containing antioxidants were determined...
January 10, 2019: Analytica Chimica Acta
Kyle B Lynch, Jiangtao Ren, Matthew A Beckner, Chiyang He, Shaorong Liu
In this article we survey 256 references (with an emphasis on the papers published in the past decade) on monolithic columns for intact protein separation. Protein enrichment and purification are included in the broadly defined separation. After a brief introduction, we describe the types of monolithic columns and modes of chromatographic separations employed for protein separations. While the majority of the work is still in the research and development phase, papers have been published toward utilizing monolithic columns for practical applications...
January 10, 2019: Analytica Chimica Acta
Michele Protti, Roberto Mandrioli, Laura Mercolini
Volumetric absorptive microsampling (VAMS) is a recent microsampling technique used to obtain dried specimens of blood and other biological matrices for application to a plethora of bioanalytical purposes. As such, it can be likened to dried blood spot (DBS) technique that has been in wide use for the last 40 years. However, VAMS promises to bring some significant advantages over DBS, related to sampling volume accuracy, haematocrit (HCT) dependence, pre-treatment and automation. Although some aspects still need to be investigated in depth, VAMS is increasingly recognised as a viable alternative to DBS and other dried microsampling techniques...
January 10, 2019: Analytica Chimica Acta
Sheng-Dong Pan, Xiao-Hong Chen, Hao-Yu Shen, Xiao-Ping Li, Mei-Qiang Cai, Yong-Gang Zhao, Mi-Cong Jin
This article has been retracted at the request of the Editor after the corresponding author pointed the Editor to comments from an anonymous reader. The article reports electron micrographs of different preparations while showing identical images as used in previous publications by the same authors. The particles in Fig. 4C (SEM image of Fe3O4@SiO2) are identical to each other and the corresponding author confirmed that these have been copy-pasted. In addition, these particles have previously been communicated as different substances in Fig...
January 10, 2019: Analytica Chimica Acta
Haiyang Zhang, Xiaowei Li, Yating Yao, Shujuan Ma, Zhen Liu, Junjie Ou, Yinmao Wei, Mingliang Ye
Hierarchically porous monoliths as a key feature of biological materials have been applied in enrichment and separation. In this work, a metal immobilized hierarchically porous organosilica hybrid monolith was synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and diethoxyphosphorylethyl-triethoxysilane (DPTS) under alkaline environment. Phosphonate ester groups were firstly introduced by the employment of DPTS as functional monomer, and then acidified to phosphonic acids. The surface area of optimal monolith could reach to 1170 m2 /g, which simultaneously contained micropores and mesopores (4 nm) obtained from nitrogen sorption measurement...
January 10, 2019: Analytica Chimica Acta
Piotr Kowalski, Ilona Olędzka, Alina Plenis, Natalia Miękus, Michał Pieckowski, Tomasz Bączek
In this study, a field amplified sample injection (FASI) and hydrophobic interaction electrokinetic chromatography (HIEKC) method has been developed for the separation of five macrolide antibiotics: spiramycin, ivermectin, tylosin, josamycin, rapamycin, and one ansamycin drug - rifamycin. By the manipulation of both the sample and separation buffer compositions, their pH values and molarity, a systematic approach has been achieved to maximize analyte differential electrophoretic mobility and signal amplification...
January 10, 2019: Analytica Chimica Acta
Shi-Li Shen, Xiao-Qing Huang, Hong-Li Jiang, Xiao-Hui Lin, Xiao-Qun Cao
A rhodamine B-based derivative (RL1) was developed as a specific fluorescent probe for HOCl. Meanwhile, morpholine moiety was introduced into the probe. It was found that the probe could display highly selective, sensitive and naked-eye detection upon the addition of HOCl. And the detection limit (LOD) was calculated to be as low as 2.8 nM. Furthermore, cellular confocal microscopic studies revealed that the introduction of morpholine moiety realized the lysosome-targeting capability. Moreover, RL1 was successfully applied for the imaging of endogenous HOCl with low cytotoxicity...
January 10, 2019: Analytica Chimica Acta
Li Shangguan, Yuanqing Wei, Kan Wang, Yuanjian Zhang, Songqin Liu
Current in vitro bioassays of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, a major threat carcinogen) are relied on murine cells and fluorescent probe 7-ethoxyresorufin (7-ER), in which TCDD mostly causes abnormal expression of cytochrome P450 1A1 (CYP1A1). However, for human cells, TCDD mainly leads to a distinct abnormal expression of cytochrome P450 1A2 (CYP1A2). The poor response of 7-ER to CYP1A2 limits the traditional bioassay for human cells. Herein, we report a fluorescent probe N-(3-hydroxybutyl)-4-methoxy-1,8-naphthalimide (HBMN) for in vitro bioassay of TCDD with human cells...
January 10, 2019: Analytica Chimica Acta
Fangfang Xue, Fei Qu, Wenli Han, Lian Xia, Jinmao You
Metal nanoclusters protected by glutathione (GSH) have attracted a wide attention due to the unique aggregation-induced emission (AIE) feature. However, the "trigger" effects of ethanol, temperature, pH values, and metal ions may restrict the application of these particles. In this work, the amino modified silicon nanoparticles (SiNPs) and GSH-capped gold nanoclusters (GSH-AuNCs) can self-assemble into well-defined spherical particles due to the electrostatic interaction. As a result, the unique aggregation-induced emission enhancement (AIEE) of GSH-AuNCs arises at 570 nm, and the SiNPs keep their own blue fluorescence at 450 nm, so a novel nanohybrid probe (SiNPs@GSH-AuNCs) with dual-emission property has been constructed...
January 10, 2019: Analytica Chimica Acta
Azadeh Nilghaz, Xiaonan Lu
This work demonstrates a sensitive and rapid method for the detection of antibiotic residues in food samples by employing the filtration behaviour of paper combined with aggregation and precipitation of chemical reagents. Using this concept, we successfully determined the presence of oxytetracycline and norfloxacin residues in pork using metal complexation on microfluidic paper-based analytical devices (μPADs). The base substrate (top layer of the device) was fabricated by printing letter channels of the words "oxytetracycline" and "norfloxacin" before functionalization with copper (II) sulfate pentahydrate in 0...
January 10, 2019: Analytica Chimica Acta
Pablo Llano Suárez, Marta García-Cortés, María Teresa Fernández-Argüelles, Jorge Ruiz Encinar, Marta Valledor, Francisco Javier Ferrero, Juan Carlos Campo, José Manuel Costa-Fernández
Inorganic nanoparticles are a fascinating class of materials which promise great potential in numerous fields, including optical (bio)sensing. Many different kinds of such nanoparticles have been widely used for fluorescent sensing and imaging due to the different merits of fluorescent nanoparticles compared to molecular fluorophores. Progress made in the rational design of nanomaterials also allowed the synthesis of hybrid phosphorescent nanoparticles, that finds growing applications in sensing due to the combination of the interesting size- and shape-dependent properties of nanomaterials with a phosphorescence-type emission...
January 10, 2019: Analytica Chimica Acta
Marcella Nunziato, Maria Valeria Esposito, Flavio Starnone, Maria Angela Diroma, Alessandra Calabrese, Valentina Del Monaco, Pasqualina Buono, Giuseppe Frasci, Gerardo Botti, Massimiliano D'Aiuto, Francesco Salvatore, Valeria D'Argenio
By analyzing multiple gene panels, next-generation sequencing is more effective than conventional procedures in identifying disease-related mutations that are useful for clinical decision-making. Here, we aimed to test the efficacy of an 84 genes customized-panel in BRCA1 and BRCA2 mutation-negative patients. Twenty-four patients were enrolled in this study. DNA libraries were prepared using a picodroplet PCR-based approach and sequenced with the MiSeq System. Highly putative pathogenic mutations were identified in genes other than the commonly tested BRCA1/2: 2 pathogenic mutations one in TP53 and one in MUTYH; 2 missense variants in MSH6 and ATM, respectively; 2 frameshift variants in KLLN, and ATAD2, respectively; an intronic variant in ANPEP, and 3 not functionally known variants (a frameshift variant in ATM a nonsense variant in ATM and a missense variant in NFE2L2)...
January 10, 2019: Analytica Chimica Acta
Shuai Sun, Shunjun Xu, Yijuan Xu, Longgang Guo, Hailing Liu, Liu Yang, Zhengtao Wang, Li Yang
In this paper, a novel high throughput screening method for antioxidants was described. The screening process was completed on a 5 cm × 5 cm silica gel 60 plate. Luminol was used as the fluorogenic substrate while hydrogen peroxide employed to excite the chemiluminescence. A dark spot was observed due to quenching effect of antioxidant. A linear model of the integral area of the spot as a function of analyte amount was fit by using vitamin C as positive control. Excellent linearity (R2  = 0.9978) was obtained in the range of 2...
January 10, 2019: Analytica Chimica Acta
Nicholas A Owens, Colin C Young, Lars B Laurentius, Prithwiraj De, Delphi Chatterjee, Marc D Porter
The development of an accurate and rapid diagnostic test for tuberculosis (TB) to use at point of need is vital to efforts aimed at reducing the global burden from this disease. This paper builds on our previous studies of mannose-capped lipoarabinomannan (ManLAM) as a serum biomarker for active TB infection by means of a heterogeneous immunoassay. That work found that complexation with components in serum (e.g., proteins) sterically hindered the capture and/or labeling of ManLAM in an immunoassay at levels <10 ng mL-1 , compromising the clinical utility of this biomarker for detection of active TB infection...
January 10, 2019: Analytica Chimica Acta
José Ángel Salatti-Dorado, Soledad González-Rubio, Diego García-Gómez, Rafael Lucena, Soledad Cárdenas, Soledad Rubio
Supramolecular solvent (SUPRAS) extraction is gaining attraction as a sample treatment technique because of its great performance in terms of effectiveness, versatility, sample clean-up, quickness, cost and sustainability. However, the nature of SUPRASs, being formed by amphiphile molecules, results in poor compatibility with Gas Chromatography (GC). Here, we show the hitherto unexplored development of a SUPRAS with high thermal stability (HTS) suitable for subsequent direct analysis by Headspace (HS)-GC. This novel HTS-SUPRAS, based on poly-undecylenic acid -an oligomeric surfactant-, tetraglyme -a polar aprotic solvent with excellent chemical and thermal stability- and water, was fully characterized in terms of composition and physical properties such as thermal stability...
January 10, 2019: Analytica Chimica Acta
Mohga Khater, Alfredo de la Escosura-Muñiz, Daniel Quesada-González, Arben Merkoçi
Tristeza is one of the destructive diseases of citrus causing by citrus tristeza virus (CTV). Historically, CTV has been associated with serious outbreaks of quick decline of citrus, therefore CTV monitoring is important aspect for avoiding such re-emerging epidemics, which would threat citrus production through the world. In this context, we have designed for the first time a label-free impedimetric biosensor for the detection of nucleic acid of CTV. The sensing platform based on a screen-printed carbon electrode (SPCE) was modified by electrodeposited gold nanoparticles (AuNPs), which allowed to efficiently immobilizing thiolated ssDNA probes as well to enhance the electrode conductivity...
January 10, 2019: Analytica Chimica Acta
Xingxing Wu, Shucheng Wu, Yingchun Li, Han Chen, Qunhui Yuan, Wei Gan
Lately, an "all-in-one" strategy via direct pyrolysis of protic salt has attracted great attention in the preparation of hetero-doped porous carbons due to its distinctive simplicity. However, protic salt derived carbons usually process large grain sizes thus hamper their applications. Herein, a protic salt derived N, S co-doped porous carbon (N, S-PC) with improved porosity was synthesized by nanocasting and carbonization of protic salt. In the nanocasting silica sphere was used as auxiliary template and an easily obtained protic salt ([pPDA][nHSO4 ]) was served as C, N and S sources...
January 10, 2019: Analytica Chimica Acta
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