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Analytica Chimica Acta

Weiyong Feng, Shengyi Gong, Enbo Zhou, Xinyu Yin, Guoqiang Feng
In this paper, a new colorimetric and ratiometric fluorescent probe for the rapid detection of phosgene is reported. This probe is based on a readily prepared and highly fluorescent iminocoumarin, which reacts rapidly with phosgene to form a cyclic carbamate product to produce, distinctive colorimetric and ratiometric fluorescent signal changes. The detection of phosgene with this probe is fast (complete within 2 min), highly selective and sensitive with a detection limit of 27 nM in solution. Moreover, this probe can be used to prepare easy-to-use paper test strips for convenient visual and fluorescent detection of phosgene gas even at a concentration of 0...
October 31, 2018: Analytica Chimica Acta
Anna Rita Bizzarri, Ilaria Moscetti, Salvatore Cannistraro
p53 is a powerful transcription factor playing a pivotal role in the prevention of cancer development and in maintaining genome integrity. This oncosuppressor is found to be functionally inactivated by mutations in many human tumors. Accordingly, wild type p53 and its oncogenic mutants represent valuable cancer biomarkers for diagnostic and prognostic purposes. We developed a highly sensitive biosensor, based on Surface Enhanced Raman Spectroscopy, for detection of wild type p53 and of p53R175H , which is one of the most frequent tumor-associated mutants of p53...
October 31, 2018: Analytica Chimica Acta
Yan He, Minggang Zhao, Meiyan Yu, Yunpeng Zhuang, Frank Cheng, Shougang Chen
3D NiO/polyaniline p-p junction foam was prepared and applied for electrochemical detection of Cr6+ . The electrochemical detection using interfacial potential barrier was illustrated and a mature theoretical model was built to demonstrate the mechanism. Electrochemical sensing signals of targets can be revealed by changing the height of potential barrier after specific adsorption. The extra high sensitivity (0.78 μA nM-1 ) and low detection limit (3.96 × 10-4  nM) of Cr6+ were achieved by applying the p-p junction interfacial potential barrier as driven factors...
October 31, 2018: Analytica Chimica Acta
Young-Ji Kim, Hong-Seok Kim, Jung-Whan Chon, Dong-Hyeon Kim, Ji-Yeon Hyeon, Kun-Ho Seo
Campylobacter is the most common cause of infectious intestinal disease, with nearly all cases caused by two species: C. jejuni and C. coli. We recently reported a gold nanoparticle-based two-stage aptasensing platform, which was improved in the present study for the rapid and on-site detection of both C. jejuni and C. coli in food samples. Compared to the previous platform, the improved platform yielded a more obvious colour change from red to purple due to the aggregation of gold nanoparticles, and does not require additional time or a pH optimization step for the aptamers to be adsorbed onto the gold nanoparticles...
October 31, 2018: Analytica Chimica Acta
Jiehua Ma, Hai Shi, Meiling Zhang, Chao Li, Yang Xiang, Ping Liu
Cancer stem cells (CSCs) are responsible for maintaining tumor growth, metastasis and recurrence. The high expression of cancer stem cell transcription factors (Oct4, Sox2 and Nanog) is a valuable prognostic factor, suggesting a higher risk of tumor recurrence and metastasis. So, the development of a convenient and cost-effective method for multiplex assay of these transcription factors (TFs) is highly required. In this work, we have proposed a universal homogeneous assay for multicolor detection of these TFs based on anti-dsDNA antibody-decorated Fe3 O4 magnetite nanoparticles (aadMNPs)...
October 31, 2018: Analytica Chimica Acta
Ting Li, Song Lu Li, Cheng Fang, Yun Nan Hou, Qiaoxia Zhang, Xin Du, Hon Cheung Lee, Yong Juan Zhao
BACKGROUND: CD38 is a surface membrane antigen highly expressed in malignant blood cells, such as multiple myeloma (MM). A soluble form of CD38 (sCD38) is also present in the plasma, deriving likely from the shedding from the cells. The plasma levels of sCD38 should thus correlate closely with the proliferation of the MM cells, allowing the development of a simple diagnostic blood test for monitoring the progress of the disease. However, the plasma sCD38 levels are extremely low, requiring the design of a highly sensitive and specific assay...
October 31, 2018: Analytica Chimica Acta
Jumei Liu, Ye Zhang, Qianwen Zhao, Bo Situ, Jiamin Zhao, Shihua Luo, Bo Li, Xiaohui Yan, Pankaj Vadgama, Lei Su, Wen Ma, Wen Wang, Lei Zheng
The presence of cancer cells in body fluids confirms the occurrence of metastasis and guides treatment. A simple, fast, and homogeneous fluorescent method was developed to detect cancer cells based on catalytic hairpin assembly (CHA) and bifunctional aptamers. The bifunctional aptamer had a recognition domain for binding to target cancer cells and an initiator domain for triggering the CHA reaction. In the presence of target cells, the bifunctional aptamer was released from the inhibitor and initiated a cascade reaction of assembly and disassembly of the hairpins...
October 31, 2018: Analytica Chimica Acta
Zhucui Li, Yan Lu, Yufeng Guo, Haijie Cao, Qinhong Wang, Wenqing Shui
Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS data. Although a number of software packages have been developed to facilitate untargeted data processing, they have not been comprehensively scrutinized in the capability of feature detection, quantification and marker selection using a well-defined benchmark sample set. In this study, we acquired a benchmark dataset from standard mixtures consisting of 1100 compounds with specified concentration ratios including 130 compounds with significant variation of concentrations...
October 31, 2018: Analytica Chimica Acta
Yan Hong, Chaoqun Huang, Sheng Liu, Lei Xia, Chengyin Shen, Yannan Chu
In order to suppress or eliminate the spurious peaks and improve signal-to-noise ratio (SNR) of Hadamard transform ion mobility spectrometry (HT-IMS), a normal-inverse bimodule operation Hadamard transform - ion mobility spectrometry (NIBOHT-IMS) technique was developed. In this novel technique, a normal and inverse pseudo random binary sequence (PRBS) was produced in sequential order by an ion gate controller and utilized to control the ion gate of IMS, and then the normal HT-IMS mobility spectrum and the inverse HT-IMS mobility spectrum were obtained...
October 31, 2018: Analytica Chimica Acta
Kajorngai Thajee, Lu Wang, Kate Grudpan, Eric Bakker
Potassium ion concentration can be successfully determined volumetrically by moving the titration from a homogeneous phase to a two phase solvent system. This is because potassium can be readily complexed in a selective and thermodynamically stable manner by ionophores such as valinomycin. Previous work demonstrated the successful titration of potassium by ion-exchange into an organic phase containing valinomycin, but the sample itself served as titrant, which is not sufficiently practical for routine applications...
October 31, 2018: Analytica Chimica Acta
Xintong Xie, Junhui Wang, Juan Zheng, Junlong Huang, Chuyi Ni, Jie Cheng, Zhengping Hao, Gangfeng Ouyang
A cost-effective microporous polymer was synthesized using cheap monomer and catalyst via one-step Scholl-coupling reaction, and its chemical, morphological characteristics and pore structure were investigated. The as-synthesized polymer with large surface area and narrow pore distribution (centered in 1.2 nm) was prepared as a fiber coating for solid-phase microextraction (SPME). Headspace SPME was used for the extraction of the light aromatic compounds, e.g. benzene, toluene, ethylbenzene, m-xylene, naphthalene and acenaphthene...
October 31, 2018: Analytica Chimica Acta
Shaohua Ding, Zhipeng Gu, Ruhong Yan, Yuguo Tang, Peng Miao
Sensitive and specific detection of protein is of great significance for early diagnosis and prognosis of many diseases. However, great challenges remain unsolved including relative low sensitivity, high cost, long testing time, complicated instrument and laborious operation. To improve the performance of protein detection methods, development of fine reaction interface for recognition and signal amplification is of great importance. In this work, we construct a novel mode of DNA assembly at electrode interface based on a tripodal surface anchor and an electrochemical aptasensor for protein assay is developed...
October 31, 2018: Analytica Chimica Acta
Yashuang Hei, Xiqian Li, Xiao Zhou, Jingju Liu, Mehboob Hassan, Siyi Zhang, Yu Yang, Xiangjie Bo, Hsing-Lin Wang, Ming Zhou
In this work, the three-dimensional nitrogen-doped nanostructured carbons with hierarchical architectures (3D-NNCsHAs) with high density of defective sites, high surface area and pluralities of pore size distributions was prepared through the pyrolysis of sea-tangle (Laminaria japonica), an inexpensive, eco-friendly and abundant precursor. Benefitting from their structural uniqueness, a selective and sensitive ascorbic acid (AA) sensor based on 3D-NNCsHAs was developed. Compared to the glassy carbon electrode (GCE) and the carbon nanotubes modified GCE (CNTs/GCE), the 3D-NNCsHAs modified GCE (3D-NNCsHAs/GCE) presents higher performance towards the electrocatalysis and detection of AA, such as lower detection limit (1 μM), wider linear range (10-4410 μM) and lower electrooxidation peak potential (-0...
October 31, 2018: Analytica Chimica Acta
Dhanjai, Ankita Sinha, Lingxia Wu, Xianbo Lu, Jiping Chen, Rajeev Jain
No abstract text is available yet for this article.
October 31, 2018: Analytica Chimica Acta
Agnès Le Masle, Sandra Santin, Léa Marlot, Ludovic Chahen, Nadège Charon
Biomass fast pyrolysis oils contain molecules having a large variety of chemical functions and a wide range of molecular weights (from several tens to several thousand grams per mole). The good knowledge of their complex composition is essential for optimizing the conversion of bio-oils to biofuels, thereby requiring powerful separation techniques. In this work, we investigate the interest of centrifugal partition chromatography (CPC) as a first dimension for the analysis of a bio-oil. A CPC method is proposed to separate oxygen containing compounds according to their partition coefficients in the solvent system...
October 31, 2018: Analytica Chimica Acta
Krzysztof Kamil Wojtanowski, Tomasz Mroczek
The high performance liquid chromatography (HPLC) coupled to electrospray ionization (ESI) octopole orthogonal acceleration time-of-flight (TOF) mass spectrometry (MS) was developed to separate secondary metabolites belonging to different groups of compounds with a wide range of polarity, i.e. phenolic acids, flavonoids, sesquiterpenes and others present in minute amounts, in a single run. Moreover, application of ESI-TOF-MS with a simple in source type of fragmentation and high mass accuracy measurements (around 2 ppm) in both positive and negative ionization modes with different and optimized fragmentor voltages, enabled the identification of each single compound based on proposed fragmentation patterns...
October 31, 2018: Analytica Chimica Acta
Stefano Cinti, Vincenzo Mazzaracchio, Gökçe Öztürk, Danila Moscone, Fabiana Arduini
The development of portable and user-friendly sensing platforms is a hot topic in the field of analytical chemistry. Among others, electroanalytical approaches exhibit a high amenability for reaching this purpose, i.e. the commercial strips for diabetes care are an obvious success. However, providing fully-integrated and user-friendly methods is the leitmotiv. In this work we evaluate the use of a disposable pipette tip, opportunely configured, to realize the first example of lab-on-a-tip. The combination of a pipette tip, wire electrodes, and cotton wool filter, highlights the suitability of producing a novel one-shot electroanalytical platform that does not require expertise-required tasks...
October 31, 2018: Analytica Chimica Acta
Pavle Jovanov, Milan Vraneš, Marijana Sakač, Slobodan Gadžurić, Jovana Panić, Aleksandar Marić, Sergej Ostojić
The biosynthesis of creatine (Cr) is closely related to the bioavailability of guanidinoacetate (GAA). The lack of one or the other may compromise their role in the energy transport and cell signaling. A reliable estimate of their levels in biological samples is imperative since they are important markers of many metabolic disorders. Therefore, a new LC-MS/MS method for simultaneous determination and quantification of GAA and Cr by multiple reaction monitoring (MRM) mode was developed based on the hydrophilic interaction chromatography (HILIC) and response surface methodology (RSM) for the optimization of chromatographic parameters...
October 22, 2018: Analytica Chimica Acta
Mohammad Russel, Marios Sophocleous, Shan JiaJia, Weiping Xu, Lehui Xiao, Thomas Maskow, Mahbub Alam, Julius Georgiou
This paper describes a novel technique to quantify and identify bacterial cultures of Bacillus Subtilis (2.10-1.30 × 109  CFU mL-1 ) and Escherichia Coli (1.60-1.00 × 109  CFU mL-1 ), in corn oil using dielectric spectroscopy at elevated frequencies of 0.0100-20.0 GHz. This technique is using the electrophysiological/biophysical differences (e.g. gram positive and gram negative) between various bacteria types, as a basis to distinguish between bacteria concentrations and bacteria types. A close-ended, coaxial probe of 20...
October 22, 2018: Analytica Chimica Acta
Chandra K Dixit, Snehasis Bhakta, John Macharia, Jared Furtado, Steven L Suib, James F Rusling
We have developed a novel method to develop epoxy silica nanoparticles (EfSiNP) in a single pot. High surface coverage of epoxy functional groups between 150 and 57000 molecules per particles (∼1013 -1016 molecules/mL of 200 nm EfSiNPs) was achieved for different preparation conditions. We then created a red colored probe by conjugating Fuchsin dye to the epoxy functionalities of EfSINPs. Anti-mouse IgG was co-immobilized with Fuchsin and their ratios were optimized for achieving optimum ratios by testing those in functional assays...
October 22, 2018: Analytica Chimica Acta
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