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Analytica Chimica Acta

Liang Chen, Dimitra L Capone, David W Jeffery
A number of polyfunctional thiols are well-recognised as some of the most potent aroma compounds in nature and have been identified in various foods, and beverages such as wine. These potent character impact compounds are present at nanogram-per-litre levels and are particularly challenging to measure. Where present, enantiomeric forms having different odour qualities further complicate the analysis. In this work, a chiral high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method using stable isotope dilution analysis (SIDA) has been developed and validated for the individual enantiomers of 3-sulfanylhexan-1-ol (3-SH, 1) and its O-acetate, 3-sulfanylhexyl acetate (3-SHA, 2), in wine after extraction as their 4-thiopyridine derivatives...
January 15, 2018: Analytica Chimica Acta
Tara Mastren, Valery Radchenko, Jonathan W Engle, John W Weidner, Allison Owens, Lance E Wyant, Roy Copping, Mark Brugh, F Meiring Nortier, Eva R Birnbaum, Kevin D John, Michael E Fassbender
Column chromatographic methods have been developed to separate no-carrier-added (111)Ag from proton irradiated thorium targets and associated fission products as an ancillary process to an existing (225)Ac separation design. Herein we report the separation of (111)Ag both prior and subsequent to (225)Ac recovery using CL resin, a solvent impregnated resin (SIR) that carries an organic solution of alkyl phosphine sulfides (R3P = S) and alkyl phosphine oxides (R3P = O). The recovery yield of (111)Ag was 93 ± 9% with a radiochemical purity of 99...
January 15, 2018: Analytica Chimica Acta
Zdena Malá, Petr Gebauer
This work describes for the first time a functional electrolyte system setup for anionic isotachophoresis (ITP) with electrospray-ionization mass-spectrometric (ESI-MS) detection in the neutral to medium-alkaline pH range. So far no application was published on the analysis of very weak acids by anionic ITP-MS although there is a broad spectrum of potential analytes with pKa values in the range 5-10, where application of this technique promises interesting gains in both sensitivity and specificity. The problem so far was the lack of anionic ESI-compatible ITP systems in the mentioned pH range as all typical volatile anionic system components are fully ionized at neutral and alkaline pH and thus too fast to suit as terminators...
January 15, 2018: Analytica Chimica Acta
Xiao-Man Hai, Nan Li, Ke Wang, Zhi-Qi Zhang, Jing Zhang, Fu-Quan Dang
In the present study, a facile fluorescence aptasensor based on two-dimensional sheet metal-organic frameworks of N,N-bis(2-hydroxyethyl)dithiooxamidato copper(II) (H2dtoaCu) was developed for the sensitive detection of adenosine triphosphate (ATP). The sensing mechanism was based on the noncovalent interaction between FAM-labeled (fluorescein amidite) ATP aptamers and H2dtoaCu. In the absence of ATP, the FAM-labeled aptamer readily adsorbs onto H2dtoaCu, mainly via π-π stacking and hydrogen bond interactions between the nucleotide bases and the H2dtoaCu surface, leading to the reduction of fluorescence intensity of the FAM by photoinduced electron transfer (PET)...
January 15, 2018: Analytica Chimica Acta
Ke-Yu Xing, Juan Peng, Dao-Feng Liu, Li-Ming Hu, Chun Wang, Guo-Qiang Li, Gang-Gang Zhang, Zhen Huang, Song Cheng, Fang-Fei Zhu, Na-Mei Liu, Wei-Hua Lai
Colloidal gold immunochromatographic assay (ICA) has poor sensitivity when used for Escherichia coli O157:H7 (E. coli O157:H7) detection. Eu (III)-doped polystyrene nanoparticle (EuNP) has a large range of stokes shift, long decay time, and wide excitation spectrum and narrow emission spectra. EuNP has been used as novel probe in ICA to improve sensitivity. In this study, carboxyl-modified EuNPs were prepared with different linkers. ICA based on EuNP, EuNP-6 carbon chain (CC) complex, EuNP-200CC complex, EuNP-1000CC complex, and EuNP-streptavidin (EuNP-SA) complex were systematically compared for the detection of E...
January 15, 2018: Analytica Chimica Acta
Wei Wang, Xiaoshan Hou, Xin Li, Chen Chen, Xiliang Luo
In this work, an effective controlled-release biosensor based on Au nanocages (AuNCs) capped with disulfide-containing DNA molecular gates was developed for ultra-sensitive and highly selective detection of glutathione (GSH). Oligonucleotides containing the S-S bonds were assembled on the surface of the AuNCs by means of electrostatic interactions in order to inhibit the release of fluorescent molecules such as Rhodamine B (RhB) loaded by AuNCs. In the presence of GSH, due to the specific cleavage of S-S bonds in disulfide-containing single-stranded DNAs (ssDNAs) as well as their subsequent departure from the surface of AuNCs, the pores could be opened, and then the dye molecules would be released from AuNCs...
January 15, 2018: Analytica Chimica Acta
A Veber, M R Cicconi, H Reinfelder, D de Ligny
A new experimental setup combining DSC, Raman and Brillouin spectroscopies was developed. In order to estimate its accuracy and stability a study of silicon and the alpha-beta quartz phase transition were performed. The data obtained demonstrated good agreement with previous studies using these three different techniques. For quartz, the temperature behavior of its 147 cm(-1) Raman mode was studied in detail. Using a two-phonon coupling treatment of the Raman band, we show for the first time that its behavior can be well described by Landau theory of first-order phase transitions...
January 15, 2018: Analytica Chimica Acta
Lucia D'Ulivo, Roberto Spiniello, Massimo Onor, Beatrice Campanella, Zoltan Mester, Alessandro D'Ulivo
The behavior of NaBH4 (THB) and the amine boranes, NH3BH3 (AB), tertbutylNH2BH3 (TBAB), Me2NHBH3 (DMAB) was investigated in continuous flow chemical vapor generation of H2Se from aqueous Se(IV) coupled with atomic absorption spectrometry. Unexpected higher efficiency of H2Se generation was obtained with amine boranes compared to THB (TBAB > AB > THB) using millimolar concentration of reductant (0.001-0.1 mol L(-1)) under strongly acidic conditions (HCl, HClO4, H2SO4, HNO3, 0.5-5 mol L(-1) H(+))...
January 15, 2018: Analytica Chimica Acta
Dhanjai, Ankita Sinha, Lingxia Wu, Xianbo Lu, Jiping Chen, Rajeev Jain
Bisphenols (BPs) are well known endocrine disrupting chemicals (EDCs) that cause adverse effects on the environment, biotic life and human health. BPs have been studied extensively because of an increasing concern for the safety of the environment and for human health. They are major raw materials for manufacturing polycarbonates, thermal papers and epoxy resins and are considered hazardous environmental contaminants. A vast array of sensors and biosensors have been developed for the sensitive screening of BPs based on carbon nanomaterials (carbon nanotubes, fullerenes, graphene and graphene oxide), quantum dots, metal and metal oxide nanocomposites, polymer nanocomposites, metal organic frameworks, ionic liquids and molecularly imprinted polymers...
January 15, 2018: Analytica Chimica Acta
Senwu Li, Kaiguang Yang, Lukuan Liu, Baofeng Zhao, Yuanbo Chen, Xiao Li, Lihua Zhang, Yukui Zhang
Tailor-made materials for the purification of proteins with His-tag was designed through synergizing the selectivity of surface sieving and metal ion affinity. By excluding impurity proteins out of the surface polymer network, such materials could purify His-tagged proteins from the crude cell lysis with purity up to 90%, improved by 14% compared to that obtained by the commercial metal chelating affinity materials. This study might promote the His-tagged protein purification to a new level.
January 2, 2018: Analytica Chimica Acta
Somayeh Arghavani-Beydokhti, Maryam Rajabi, Alireza Asghari
In this work, a new, simple, rapid, and environmentally friendly method with a high sample clean-up capability termed as centrifugeless ultrasound-assisted dispersive micro solid-phase extraction coupled with salting-out ultrasound-assisted liquid-liquid microextraction based on solidification of a floating organic droplet followed by high performance liquid chromatography is introduced for the first time. In this method, the three non-steroidal anti-inflammatory drugs diclofenac, ibuprofen, and mefenamic acid are first extracted based on an effective nanoadsorbent named as the layered double hydroxide-carbon nanotube nanohybrid...
January 2, 2018: Analytica Chimica Acta
Lihua Zhao, Zhanfang Ma
Sensitivity enhancement and proteins adsorption are the common challenges faced in protein immunoassays. In this work, an ultrasensitive and protein-resistant label-free amperometric immunosening platform for carcinoma antigen-125 (CA125) based on redox polyaniline-polythionine hydrogel (PANI-PThi gel) was developed. The as-prepared hydrogel, which was facilely synthesized by electropolymerization, exhibited good conductivity and strong hydrophilicity while the sensitivity and specificity of the immunosensor can be enhanced...
January 2, 2018: Analytica Chimica Acta
Zhengyi Qu, Weidan Na, Xiaotong Liu, Hua Liu, Xingguang Su
In this paper, we developed a sensitive fluorescence biosensor for tyrosinase (TYR) and acid phosphatase (ACP) activity detection based on nitrogen-doped graphene quantum dots (N-GQDs). Tyrosine could be catalyzed by TYR to generate dopaquinone, which could efficiently quench the fluorescence of N-GQDs, and the degree of fluorescence quenching of N-GQDs was proportional to the concentration of TYR. In the presence of ACP, l-Ascorbic acid-2-phosphate (AAP) was hydrolyzed to generate ascorbic acid (AA), and dopaquinone was reduced to l-dopa, resulting in the fluorescence recovery of the quenched fluorescence by dopaquinone...
January 2, 2018: Analytica Chimica Acta
Zuzana Chaloupková, Anna Balzerová, Jitka Bařinková, Zdenka Medříková, Pavel Šácha, Petr Beneš, Václav Ranc, Jan Konvalinka, Radek Zbořil
Prostate cancer is one of the most common cancers among men and can in its later stages cause serious medical problems. Due to the limited suitability of current diagnostic biochemical markers, new biomarkers for the detection of prostate cancer are highly sought after. An ideal biomarker should serve as a reliable prognostic marker, be applicable for early diagnosis, and be applicable for monitoring of therapeutic response. One potential candidate is glutamate carboxypeptidase II (GCPII), also known as prostate specific membrane antigen (PSMA), which has a promising role for direct imaging...
January 2, 2018: Analytica Chimica Acta
Bin Bin Zhang, Yi Shi, Hui Chen, Qing Xia Zhu, Feng Lu, Ying Wei Li
By coupling surface-enhanced Raman spectroscopy (SERS) with thin-layer chromatography (TLC), a powerful method for detecting complex samples was successfully developed. However, in the TLC-SERS method, metal nanoparticles serving as the SERS-active substrate are likely to disturb the detection of target compounds, particularly in overlapping compounds after TLC development. In addition, the SERS detection of compounds that are invisible under both visible light and UV254/365 after TLC development is still a significant challenge...
January 2, 2018: Analytica Chimica Acta
Longjun Gu, Guodong Yu, Cheuk-Wing Li
Since polydimethylsiloxane (PDMS) is notorious for its severe sorption to biological compounds and even nanoparticles, thermoplastics become a promising substrate for microdevices. Although CO2 laser engraving is an efficient method for thermoplastic device fabrication, it accompanies with poor bonding issues due to severe bulging and large feature size determined by the diameter of laser beam. In this study, a low-cost microfabrication method is proposed by reversibly sealing a 1 mm thick polymethylmethacrylate (PMMA) over an engraving substrate to reduce channel feature size and minimize bulges of laser engraved channels...
January 2, 2018: Analytica Chimica Acta
Eduardo Luiz Rossini, Maria Izabel Milani, Emanuel Carrilho, Leonardo Pezza, Helena Redigolo Pezza
In this paper, we describe a validated paper-based microfluidic analytical device for the simultaneous quantification of two important biomarkers of renal function in urine. This paper platform provides an inexpensive, simple, and easy to use colorimetric method for the quantification of creatinine (CRN) and uric acid (UA) in urine samples. The microfluidic paper-based analytical device (μPAD) consists of a main channel with three identical arms, each containing a circular testing zone and a circular uptake zone...
January 2, 2018: Analytica Chimica Acta
Xuejun Cui, Rongguo Li, Xiaofei Liu, Jingfeng Wang, Xueqi Leng, Xiaolei Song, Qianqian Pei, Yu Wang, Su Liu, Jiadong Huang
Herein, we have reported the development of a simple, rapid, and low cost colorimetric method for the detection of antibiotic based on target-activated split peroxidase DNAzyme coupled with dual nicking enzyme signal amplification (NESA). To lower background signal in G-quadruplex DNAzyme-based detection, the two split G-rich parts are caged into two different hairpin probes, respectively, preventing the two parts from assembling into the G-quadruplex structure. By the combination of restriction endonuclease-assisted cleavage reaction with the spilt G-quadruplex probes, target-modulated release of the two split G-rich parts is achieved, affording high specificity of antibiotic detection...
January 2, 2018: Analytica Chimica Acta
Ashley E Richardson, Neil D Danielson
Hydrophilic interaction liquid chromatography (HILIC) has become increasingly popular as an alternative to reversed phase LC due to its ease of separating complex polar compound mixtures and the compatibility of the mobile phase with mass spectrometry (MS). Using a plain silica column (150  mm × 4.6  mm), we have shown a mixture containing three hydroxybenzoic acid isomers plus syringic and vanillic acid and three hydroxycinnamic acid isomers plus ferulic and sinapic acid can be separated using a mobile phase comprised of 90% acetonitrile (MeCN) and 10% 20 mM ammonium acetate at pH 6 in under 45 min...
December 15, 2017: Analytica Chimica Acta
Ángel Sánchez-Illana, Sudhin Thayyil, Paolo Montaldo, Dorothea Jenkins, Guillermo Quintás, Camille Oger, Jean-Marie Galano, Claire Vigor, Thierry Durand, Máximo Vento, Julia Kuligowski
Oxidative stress derived from perinatal asphyxia appears to be closely linked to neonatal brain damage and lipid peroxidation biomarkers have shown to provide predictive power of oxidative stress related pathologies in situations of hypoxia and reoxygenation in the newborn. The objective of this work was to develop and validate of a comprehensive liquid chromatography tandem mass spectrometry approach for the quantitative profiling of 28 isoprostanoids in newborn plasma samples covering a broad range of lipid peroxidation product classes...
December 15, 2017: Analytica Chimica Acta
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