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Analytica Chimica Acta

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https://www.readbyqxmd.com/read/28224913/parent-heparin-and-daughter-lmw-heparin-correlation-analysis-using-lc-ms-and-nmr
#1
Xinyue Liu, Kalib St Ange, Xiaohua Wang, Lei Lin, Fuming Zhang, Lianli Chi, Robert J Linhardt
Heparin is a structurally complex, polysaccharide anticoagulant derived from livestock, primarily porcine intestinal tissues. Low molecular weight (LMW) heparins are derived through the controlled partial depolymerization of heparin. Increased manufacturing and regulatory concerns have provided the motivation for the development of more sophisticated analytical methods for determining both their structure and pedigree. A strategy, for the comprehensive comparison of parent heparins and their LMW heparin daughters, is described that relies on the analysis of monosaccharide composition, disaccharide composition, and oligosaccharide composition...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224912/high-throughput-screening-and-quantitation-of-guanidino-and-ureido-compounds-using-liquid-chromatography-drift-tube-ion-mobility-spectrometry-mass-spectrometry
#2
Ruo-Jing Fan, Fang Zhang, Xiu-Ping Chen, Wan-Shu Qi, Qing Guan, Tuan-Qi Sun, Yin-Long Guo
The present work focused on the high-throughput screening and quantitation of guanidino compounds (GCs) and ureido compounds (UCs) in human thyroid tissues. The strategy employed benzylic rearrangement stable isotope labeling (BRSIL) for the sample preparation and then detection using liquid chromatography-drift tube ion mobility spectrometry-quadrupole time of flight mass spectrometry (LC-DTIMS-QTOF MS). A short reversed-phase LC realized an on-line desalting and a measurement cycle of 5.0 min. DTIMS separation enhanced the better specificity and selectivity for the benzil labeled GCs and UCs...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224911/determination-of-total-cyanide-in-soil-by-isotope-dilution-gc-ms-following-pentafluorobenzyl-derivatization
#3
Beatrice Campanella, Lorenzo Biancalana, Lucia D'Ulivo, Massimo Onor, Emilia Bramanti, Zoltan Mester, Enea Pagliano
The high toxicity of cyanide, along with its widespread industrial use, has fuelled interest in the development of analytical methods for its determination in complex matrices. In this study, we propose a novel approach for the measurement of total cyanide in soil samples based on single-step derivatization with pentafluorobenzyl bromide (F5Bn-Br) followed by quantitation with gas chromatography mass spectrometry in negative chemical ionization mode. The reaction between CN(-) and F5Bn-Br resulted in the identification of several derivatives such as F5Bn-CN, (F5Bn)(F5Ph)CH-CN, and (F5Bn)2(F5Ph)C-CN...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224910/identification-of-sink-spots-in-two-thermal-desorption-gc-ms-systems-for-the-analysis-of-polycyclic-aromatic-hydrocarbons
#4
Yingjie Li, Jiping Zhu
Thermal desorption (TD) GC/MS has been used for the analysis of polycyclic aromatic hydrocarbons (PAHs) and other semi-volatile organic compounds. However, thermal desorption recovery of PAHs have not been well studied and the cause of PAH residues in a TD system has not been clearly understood. Our results showed that low volatility of PAHs can lead to their incomplete recovery in a TD system: for the PAHs with low vapour pressures, up to 10% and 3% could be lost in a two-stage (TS) TD system and a short-path (SP) TD system, respectively...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224909/hybrid-monolith-sorbent-of-polypyrrole-coated-graphene-oxide-incorporated-into-a-polyvinyl-alcohol-cryogel-for-extraction-and-enrichment-of-sulfonamides-from-water-samples
#5
Kochaporn Chullasat, Piyaluk Nurerk, Proespichaya Kanatharana, Pamornrat Kueseng, Thanyaporn Sukchuay, Opas Bunkoed
A hybrid monolith sorbent of polypyrrole-coated graphene oxide embedded in polyvinyl alcohol cryogel was prepared and used as an effective solid phase extraction sorbent for the determination of trace sulfonamides. The large surface areas with many adsorption sites of polypyrrole and graphene oxide facilitated the high adsorption of sulfonamides via hydrogen bonding, π-π and hydrophobic interactions. The high porosity of the polyvinyl alcohol cryogel helped to reduce the back pressure that occurs in a conventional packed solid phase extraction cartridge...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224908/comparison-of-multivariate-curve-resolution-strategies-in-quantitative-lcxlc-application-to-the-quantification-of-furanocoumarins-in-apiaceous-vegetables
#6
Daniel W Cook, Mackenzie L Burnham, David C Harmes, Dwight R Stoll, Sarah C Rutan
Comprehensive two-dimensional liquid chromatography (LC × LC) has been gaining popularity for the analysis of complex samples in a wide range of fields including metabolomics, environmental analysis, and food analysis. While LC × LC can provide greater chromatographic resolution than one-dimensional LC (1D-LC), overlapping peaks are often still present in separations of complex samples, a problem that can be alleviated by chemometric curve resolution techniques such as multivariate curve resolution-alternating least squares (MCR-ALS)...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224907/multi-block-data-analysis-using-comdim-for-the-evaluation-of-complex-samples-characterization-of-edible-oils
#7
Larissa Naida Rosa, Luana Caroline de Figueiredo, Elton Guntendorfer Bonafé, Aline Coqueiro, Jesuí Vergílio Visentainer, Paulo Henrique Março, Douglas N Rutledge, Patrícia Valderrama
The ComDim chemometrics method for multi-block analysis was employed to evaluate thirty-two vegetable oil samples analyzed by near infrared (NIR) and ultraviolet-visible (UV-Vis) spectroscopy, and by Gas Chromatography with flame ionization detection (GC-FID) for their fatty acids composition. This unsupervised pattern recognition method was able to extract information from the tables of results that could be presented in informative graphs showing the relationship between the samples through the scores, the predominance of information in particular tables through the saliences and the contribution of the variables in each table which were responsible for the similarities observed in the samples, through the loadings plots...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224906/a-comparative-study-of-sample-dissolution-techniques-and-plasma-based-instruments-for-the-precise-and-accurate-quantification-of-rees-in-mineral-matrices
#8
Laurence Whitty-Léveillé, Keven Turgeon, Claude Bazin, Dominic Larivière
The recent commercialisation of inductively coupled plasma tandem mass spectrometric (ICP-MS/MS) instruments has provided analytical chemists with a new tool to properly quantify atomic composition in a variety of matrices with minimal sample preparation. In this article, we report on our assessment of the compatibility of 3 sample preparation techniques (open-vessel acid digestion, microwave digestion and alkaline fusion) for the quantification of rare earth elements (REEs) in mineral matrices. The combination of the high digestion temperatures (1050 °C) and using LiBO2 as a flux was the most effective strategy for the digestion of all rare earth elements in mineral matrices and was compatible with ICP-MS/MS measurements...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224905/emerging-trends-in-biosensing-using-stripping-voltammetric-detection-of-metal-containing-nanolabels-a-review
#9
REVIEW
Christos Kokkinos, Anastasios Economou
Over the last years, nanomaterials have found many applications in the development of electrochemical biosensors. Among other functions, metal nanoparticles (NPs) and quantum dots (QDs) (semiconducting nanocrystals composed of metal salts) are increasingly being used as voltammetric labels in affinity biosensing. Labeling is based on the attachment of the label(s) on the target biomolecules or on a biorecognition reporting probe. After an appropriate specific affinity interaction between the target and the reporting probe, the metallic nanolabels are converted to the respective cations which are quantified by a voltammetric technique...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224904/design-development-and-method-validation-of-a-novel-multi-resonance-microwave-sensor-for-moisture-measurement
#10
Johanna Peters, Wolfgang Taute, Kathrin Bartscher, Claas Döscher, Michael Höft, Reinhard Knöchel, Jörg Breitkreutz
Microwave sensor systems using resonance technology at a single resonance in the range of 2-3 GHz have been shown to be a rapid and reliable tool for moisture determination in solid materials including pharmaceutical granules. So far, their application is limited to lower moisture ranges or limitations above certain moisture contents had to be accepted. Aim of the present study was to develop a novel multi-resonance sensor system in order to expand the measurement range. Therefore, a novel sensor using additional resonances over a wide frequency band was designed and used to investigate inherent limitations of first generation sensor systems and material-related limits...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224903/in%C3%A2-vivo-near-infrared-fluorescence-imaging-of-amyloid-%C3%AE-plaques-with-a-dicyanoisophorone-based-probe
#11
Jia-Ying Zhu, Lin-Fu Zhou, Yu-Kun Li, Shuo-Bin Chen, Jin-Wu Yan, Lei Zhang
A dicyanoisophorone-based probe with two-photon absorption and NIR emission was developed for the in vivo fluorescence imaging of amyloid-β plaques, which exhibited high selectivity toward Aβ aggregates over other intracellular proteins. The detection limit was calculated to be as low as 109 nM. In vivo imaging studies indicated that the probe could penetrate the blood-brain barrier and label Aβ plaques in the living transgenic mice, and its specific binding to cerebral Aβ plaques was further confirmed by one- and two-photon ex vivo fluorescence imaging...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224902/a-quartz-crystal-microbalance-sensor-for-endotoxin-assay-by-monitoring-limulus-amebocyte-lysate-protease-reaction
#12
Tao Liu, Wei Zhang, Lianqun Zhou, Zhen Guo, Yuguo Tang, Peng Miao
Endotoxin is able to trigger strong innate immune responses by interacting with specific receptors on immune cells. Therefore, accurate and rapid detection of endotoxin is of primary importance. In this study, endotoxin induced viscosity variation of limulus amebocyte lysate (LAL) reagent is monitored by a quartz crystal microbalance (QCM) sensor with enhanced signal. Based on the analysis of the relationship between endotoxin concentration and QCM frequency shift with time, an effective sensing strategy is developed for endotoxin assay, which shows excellent sensitivity and specificity in the linear detection range from 0...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224901/an-ssdna-library-immobilized-selex-technique-for-selection-of-an-aptamer-against-ractopamine
#13
Nuo Duan, Wenhui Gong, Shijia Wu, Zhouping Wang
An improved SELEX technique was developed for selecting aptamers against ractopamine (RAC) by immobilizing ssDNA library on the magnetic beads. After sixteen selection rounds, a highly enriched ssDNA pool was sequenced and nine families were grouped according to their homology and secondary structures analysis. One representative aptamer candidate from each family was picked out for binding affinity identification by graphene oxide (GO) adsorption platform. The aptamer RAC-6 was demonstrated as the optimal aptamer with high specificity and dissociation constant (Kd) value of 54...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224900/chemical-oxygen-demand-historical-perspectives-and-future-challenges
#14
REVIEW
René Bernard Geerdink, Ricardo Sebastiaan van den Hurk, Onno Jacob Epema
Determining the chemical oxygen demand (COD) is challenging because of the chemicals that are used in the current methods. There is an urgent need to determine the pollution in surface waters from (heavy) industry via a simple, reliable and fast method. However, the current procedures use hazardous chemicals, such as mercury, to suppress chloride interferences. This challenge has not been resolved. The introduction of modern detection techniques, such as chemiluminescence and oxidation procedures, e.g., microwave and ultrasound dissolution, has not resulted in a breakthrough...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28193366/development-of-c60-based-labeling-reagents-for-the-determination-of-low-molecular-weight-compounds-by-matrix-assisted-laser-desorption-ionization-mass-i-determination-of-amino-acids-in-microliter-biofluids
#15
Pin Wu, Hua-Ming Xiao, Jun Ding, Qian-Yun Deng, Fang Zheng, Yu-Qi Feng
Quantification of low molecular weight compounds (<800 Da) using matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI MS) is challenging due to the matrix signal interference at low m/z region and poor reproducibility of MS responses. In this study, a C60 labeling-MALDI MS strategy was proposed for the fast, sensitive and reliable determination of amino acids (AAs) in biofluids. An N-hydroxysuccinimide functionalized C60 was synthesized as the labeling reagent and added as an 880 Da tag to AAs; a carboxyl acid containing C60 was employed as the internal standards to normalize MS variations...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28193365/a-new-and-recyclable-system-based-on-tropin-ionic-liquids-for-resolution-of-several-racemic-amino-acids
#16
Zhixia Wang, Zhenbo Hou, Shun Yao, Min Lin, Hang Song
A new, recyclable solid-liquid resolution system was developed based on tropin ionic liquids [CnDTr][L-Pro]2 for the enantiomeric resolution of racemic phenylalanine and other α-substituted carboxylic acids including tryptophan, tyrosine, benzene glycine and mandelic acid. With racemic phenylalanine as resolution model, effect factors were investigated for better resolution conditions. On the conditions, some efficient resolution were achieved, for instance the e.e. (98%) and product yield (76%) in solid phase for phenylalanine, and the e...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28193364/application-of-carbon-nanosorbent-for-prime-pass-through-cleanup-of-10-selected-local-anesthetic-drugs-in-human-plasma-samples
#17
Jian-Bo Ma, Li-Ming Zhao, Qiu-Hong Rui, Yu-Feng Liao, Yan-Min Chen, Jin Xu, Yan Zhu, Yong-Gang Zhao
A novel PRiME (process, robustness, improvements, matrix effects, ease of use) pass-through cleanup procedure has been developed to improve the existing commercially available designs. Carbon nanosorbents, i.e., magnetic modified carboxyl-graphene (Mag-CG) and magnetic modified carboxyl-carbon nanotubes (Mag-CCNTs), have been synthesised and evaluated in PRiME pass-through cleanup procedure for human plasma prior to analysis of 10 selected local anesthetic drugs by liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS)...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28193363/co-solvent-enhanced-adsorption-with-magnetic-velvet-like-carbon-nitride-for-high-efficiency-solid-phase-extraction
#18
Shanshan Fan, Jun Zhu, Lixuan Ren, Man Wang, Wentao Bi, Huihui Li, Xiaohua Huang, David Da Yong Chen
Magnetic velvet-like graphitic carbon nitride (V-g-C3N4/Fe3O4) was used for rapid 1 min extraction of flavonoids from different tea extracts by co-solvent enhanced adsorptive magnetic solid phase extraction. The nanocomposite can interact with flavonoids, in which Fe3O4 provide hydrogen bond and V-g-C3N4 has hydrophobic and π-π interaction to promote adsorption. The enhanced adsorptive magnetic solid phase extraction method is developed with the addition of a co-solvent (water) to dramatically change the solvent environment, which enhanced the speed of movement of target compounds from the solvent to the sorbent and increase the adsorption capacity...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28193362/a-ftir-chemometrics-approach-to-characterize-the-gamma-radiation-effects-on-iodine-epoxy-paint-interactions-in-nuclear-power-plants
#19
Juliette Colombani, Elodie Chauvet, Sandrine Amat, Nathalie Dupuy, Didier Gigmes
The effects of radiation on polymeric materials are a topic of concern in a wide range of industries including the sterilization, and the nuclear power industry. While much work has concentrated on systems like polyolefins that are radiation sterilized, some work has been done on epoxy systems. The epoxy system studied is an epoxy/amine paint which is representative of the paint that covers the inner surfaces of the French nuclear reactor containment buildings. In case of a severe accident on a Nuclear Power Plant, fission products can be released from the nuclear fuel to the reactor containment building...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28193361/a-ray-casting-method-for-the-computation-of-the-area-of-feasible-solutions-for-multicomponent-systems-theory-applications-and-facpack-implementation
#20
Mathias Sawall, Klaus Neymeyr
Multivariate curve resolution methods suffer from the non-uniqueness of the solutions. The set of possible nonnegative solutions can be represented by the so-called Area of Feasible Solutions (AFS). The AFS for an s-component system is a bounded (s-1)-dimensional set. The numerical computation and the geometric construction of the AFS is well understood for two- and three-component systems but gets much more complicated for systems with four or even more components. This work introduces a new and robust ray casting method for the computation of the AFS for general s-component systems...
April 1, 2017: Analytica Chimica Acta
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