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Analytica Chimica Acta

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https://www.readbyqxmd.com/read/28915947/immunosensor-array-platforms-based-on-self-assembled-dithiols-for-the-electrochemical-detection-of-tetrodotoxins-in-puffer-fish
#1
Laia Reverté, Katrina Campbell, Maria Rambla-Alegre, Christopher T Elliott, Jorge Diogène, Mònica Campàs
The recent detection of tetrodotoxins (TTXs) in European fish and shellfish has emphasized the urgent need to develop specific, selective, rapid and easy-to-use methods for their detection to assess the potential risk posed to human health. For this purpose, a dithiol self-assembled monolayer (SAM)-based immunoassay previously performed on maleimide plates (mELISA) has been adapted to gold electrode arrays for the development of an electrochemical immunosensor for TTX. The electrochemical SAM-based immunosensor designed herein, provided an oriented, stable and spaced sensing platform for the determination of TTX, attaining a limit of detection of 2...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915946/a-hydrogen-peroxide-sensor-based-on-tnm-functionalized-reduced-graphene-oxide-grafted-with-highly-monodisperse-pd-nanoparticles
#2
Sait Bozkurt, Berna Tosun, Betül Sen, Süleyman Akocak, Aysun Savk, Mehmet Faruk Ebeoğlugil, Fatih Sen
Addressed herein, we report the synthesis and characterization of a tert-nonyl mercaptan (TNM) functionalized reduced graphene oxide (rGO) supported palladium (Pd) nanoparticles (NPs) (Pd/TNM@rGO) as electrochemical sensor. The highly monodisperse Pd/TNM@rGO nanocomposite was applied for electrochemical determination of hydrogen peroxide (H2O2) at a potential range of -0.6 to +0.8 V. The Pd/TNM@rGO sensor demonstrated very high activity, sensitivity, reusability and durability toward H2O2 sensing. The well dispersed Pd/TNM@rGO nanocomposite has been characterized by using several analytical techniques such as, X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), electron energy loss spectroscopy (EELS) and electrochemical impedance spectroscopy (EIS)...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915945/potentiometric-sensor-for-non-invasive-lactate-determination-in-human-sweat
#3
Massimo Onor, Stefano Gufoni, Tommaso Lomonaco, Silvia Ghimenti, Pietro Salvo, Fiodor Sorrentino, Emilia Bramanti
The present work describes a non invasive lactate sensing in sweat during workout. The sensing system is based on a non-equilibrium potentiometric measure performed using disposable, chemically modified, screen printed carbon electrodes (SPCEs) that can be wetted with sweat during the exercise. The potentiometric signal, which is proportional to lactate concentration in sweat, is produced by a redox reaction activated by UV radiation, as opposed to the enzymatic reaction employed in traditional, blood-based measuring devices...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915944/a-novel-substrate-inspired-fluorescent-probe-to-monitor-native-albumin-in-human-plasma-and-living-cells
#4
Guang-Bo Ge, Lei Feng, Qiang Jin, Yi-Ru Wang, Zhao-Ming Liu, Xin-Yue Zhu, Ping Wang, Jie Hou, Jing-Nan Cui, Ling Yang
Human albumin (HA) displays crucial roles in maintaining health and fighting diseases. Accurate determination of native HA in plasma or non-plasma samples are of immense significance in both basic research and clinical practice. Herein, a novel ratiometric two-photon fluorescent probe (N-butyl-4-(4-phenyl-benzoyloxy) 1,8-naphthalimide, BPBN) has been designed and developed for highly selective and sensitive sensing the enzymatic activities of HA, on the basis of its unique pseudo-esterase feature. BPBN exhibits excellent selectivity, high sensitivity and good reactivity under physiological conditions...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915943/derivatization-enhanced-separation-and-sensitivity-of-long-chain-free-fatty-acids-application-to-asthma-using-targeted-and-non-targeted-liquid-chromatography-mass-spectrometry-approach
#5
Xiqing Bian, Baoqing Sun, Peiyan Zheng, Na Li, Jian-Lin Wu
Long chain-free fatty acids (LCFFAs) play pivotal roles in various physiological functions, like inflammation, insulin resistance, hypertension, immune cell behavior and other biological activities. However, the detection is obstructed by the low contents, structural diversity, high structural similarity, and matrix interference. Herein, a fast cholamine-derivatization, within 1 min at room temperature, coupled with liquid chromatography-mass spectrometry (LC-MS) approach was developed to determine LCFFAs in complex samples...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915942/development-of-a-validated-lc-ms-ms-method-for-the-quantification-of-19-endogenous-asthma-copd-potential-urinary-biomarkers
#6
Mona M Khamis, Darryl J Adamko, Anas El-Aneed
Obstructive airways inflammatory diseases sometimes show overlapping symptoms that hinder their early and correct diagnosis. Current clinical tests are tedious and are of inadequate specificity in special population such as the elderly and children. Therefore, we are developing tandem mass spectrometric (MS/MS) methods for targeted analysis of urine biomarkers. Recently, proton-nuclear magnetic resonance ((1)H-NMR) analysis proposed 50 urinary metabolites as potential diagnostic biomarkers among asthma and chronic obstructive pulmonary disease (COPD) patients...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915941/paper-spray-and-kendrick-mass-defect-analysis-of-block-and-random-ethylene-oxide-propylene-oxide-copolymers
#7
Robert B Cody, Thierry Fouquet
Paper spray ionization coupled with a high-resolution time-of-flight mass spectrometer was applied to the analysis of 13 block and 2 random ethylene oxide/propylene oxide (EO/PO) copolymers as well as to standard samples of poly(ethylene oxide) and poly(propylene oxide) homopolymers. Paper spray mass spectra could be obtained rapidly and, unlike electrospray ionization, were not subject to contamination and sample carryover. For comparison, polyether samples were also measured on a MALDI/TOF system with ultrahigh mass resolving power...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915940/accurate-and-reliable-quantification-of-the-protein-surface-coverage-on-protein-functionalized-nanoparticles
#8
Siyao Liu, Jeannie Horak, Markus Höldrich, Michael Lämmerhofer
The ability to accurately quantify the protein coverage on nanoparticles is critical for assessing the quality of the surface chemistry and the success of the functionalization process of protein-nanoparticle conjugates. Surface coverage determination is therefore an integral part in the quality control of protein-modified nanoparticles in industrial nanotechnology. In this work, a novel and conventional method was established for direct quantification of the protein surface coverage on metallic nanoparticles...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915939/porous-organic-polymers-with-different-pore-structures-for-sensitive-solid-phase-microextraction-of-environmental-organic-pollutants
#9
Zhoubing Huang, Shuqin Liu, Jianqiao Xu, Li Yin, Juan Zheng, Ningbo Zhou, Gangfeng Ouyang
Adsorption capacity is the major sensitivity-limited factor in solid-phase microextraction. Due to its light-weight properties, large specific surface area and high porosity, especially tunable pore structures, the utilization of porous organic polymers as solid-phase microextraction adsorbents has attracting researchers' attentions. However, these works mostly concentrated on the utilization of specific porous organic polymers for preparing high-performance solid-phase microextraction coatings. The relationship between pore structures and adsorption performance of the porous organic polymers still remain unclear...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915938/a-magnetic-field-directed-self-assembly-solid-contact-for-construction-of-an-all-solid-state-polymeric-membrane-ca-2-selective-electrode
#10
Tanji Yin, Xiaojing Jiang, Wei Qin
A magnetic field-directed self-assembly solid contact has been proposed for developing an all-solid-state polymeric membrane Ca(2+)-selective electrode. The solid contact is prepared by physically adsorbing magnetic graphene powder on a magnetic gold electrode under the direction of the magnetic field. The proposed method for preparing solid contact avoids using the aqueous solutions and is simple, fast and general as compared to the multilayer drop-casting and electrodeposition methods. The all-solid-state Ca(2+)-selective electrode based on magnetic graphene as solid contact shows a stable potential response in the linear range of 1...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915937/ultra-high-performance-supercritical-fluid-chromatography-mass-spectrometry-procedure-for-analysis-of-monosaccharides-from-plant-gum-binders
#11
Volodymyr Pauk, Tomáš Pluháček, Vladimír Havlíček, Karel Lemr
The ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC/MS) procedure for analysis of native monosaccharides was developed. Chromatographic conditions were investigated to separate a mixture of four hexoses, three pentoses, two deoxyhexoses and two uronic acids. Increasing water content in methanol modifier to 5% and formic acid to 4% improved peak shapes of neutral monosaccharides and allowed complete elution of highly polar uronic acids in a single run. An Acquity HSS C18SB column outperformed other three tested stationary phases (BEH (silica), BEH 2-ethylpyridine, CSH Fluoro-Phenyl) in terms of separation of isomers and analysis time (4...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915936/high-sensitivity-and-selectivity-in-quantitative-analysis-of-drugs-in-biological-samples-using-4-column-multidimensional-micro-uhplc-ms-enabling-enhanced-sample-loading-capacity
#12
Ronald de Vries, Liesbeth Vereyken, Isabelle François, Lieve Dillen, Rob J Vreeken, Filip Cuyckens
Sensitivity is often a critical parameter in quantitative bioanalyses in drug development. For liquid-chromatography-based methods, sensitivity can be improved by reducing the column diameter, but practical sensitivity gains are limited by the reduced sample loading capacity on small internal diameter (I.D.) columns. We developed a set-up that has overcome these limitations in sample loading capacity. The set-up uses 4 columns with gradually decreasing column diameters along the flow-path (2.1 → 1 → 0...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915935/secondary-ion-mass-spectrometry-the-application-in-the-analysis-of-atmospheric-particulate-matter
#13
REVIEW
Di Huang, Xin Hua, Guang-Li Xiu, Yong-Jie Zheng, Xiao-Ying Yu, Yi-Tao Long
Currently, considerable attention has been paid to atmospheric particulate matter (PM) investigation due to its importance in human health and global climate change. Surface characterization, single particle analysis and depth profiling of PM is important for a better understanding of its formation processes and predicting its impact on the environment and human being. Secondary ion mass spectrometry (SIMS) is a surface technique with high surface sensitivity, high spatial resolution chemical imaging and unique depth profiling capabilities...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916109/systematic-approach-in-mg-2-ions-analysis-with-a-combination-of-tailored-fluorophore-design
#14
L Lvova, C Guanais Gonçalves, L Prodi, M Sgarzi, N Zaccheroni, M Lombardo, A Legin, C Di Natale, R Paolesse
A systematic study of a series of diaza-18-crown-6 8-hydroxyquinoline (DCHQ) chemosensors, devoted to Mg(II) ion detection, was performed. Functionalization of DCHQ by peripheral substituents allowed the development of novel all-solid-state optodes via inclusion inside PVC-based polymeric films. The influence on the DCHQ-based optode response of the lipophilic sites functionalization and of the nature of the plasticizer, was investigated. Fluorimetric studies on optodes sensitivity towards a number of different metal cations (Ca(2+), Na(+), K(+), Li(+), Co(2+), Cd(2+), Pb(2+), Cu(2+), Hg(2+), Zn(2+)) and NH4(+) were carried out...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916108/a-eu-iii-doped-metal-organic-framework-conjugated-with-fluorescein-labeled-single-stranded-dna-for-detection-of-cu-ii-and-sulfide
#15
Han Weng, Bing Yan
In this paper, Bio-MOF-1 is prepared as reported and then Eu(3+) is introduced into it via cation exchange method. A FAM-labeled ssDNA is chosen to fabricate with the obtained Eu(3+)@Bio-MOF-1. A luminescent hybrid material is assembled, which can exhibit the fluorescence of Eu(3+) and FAM simultaneously by adjusting the ratio of FAM-ssDNA and Eu(3+)@Bio-MOF-1. The sample is then used for the detecting of metal ions, results shows which has good selectively for Cu(2+) (LOD = 0.14 μM, 0-250 μM). The introduction of Cu(2+) can quench the fluorescence of FAM while the luminescent intensity of Eu(3+) enhancing...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916107/genetically-functionalized-ferritin-nanoparticles-with-a-high-affinity-protein-binder-for-immunoassay-and-imaging
#16
Jong-Won Kim, Woosung Heu, Sukyo Jeong, Hak-Sung Kim
Molecular detection of target molecules with high sensitivity and specificity is of great significance in bio and medical sciences. Here, we present genetically functionalized ferritin nanoparticles with a high-affinity protein binder, and their utility as a signal generator in a variety of immunoassays and imaging. As a high-affinity protein binder, human IgG-specific repebody, which is composed of LRR (Leucine-rich repeat) modules, was used. The repebody was genetically fused to the N-terminal heavy-chain ferritin, and the resulting subunits were self-assembled to the repebody-ferritin nanoparticles composed of 24 subunits...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916106/silver-nanoclusters-capped-silica-nanoparticles-as-a-ratiometric-photoluminescence-nanosensor-for-the-selective-detection-of-i-and-s-2
#17
Xinan Huang, Sohail Anjum Shahzad, Yongxin Li, Yunyi Zhang, Lijia Sang, Huipeng Zhou, Hong Jiang, Kenneth Kam-Wing Lo, Cong Yu
A novel and efficient approach has been established for the synthesis of silver nanoclusters capped silica nanoparticles (SiO2@AgNCs). These nanoclusters (AgNCs) capped silica nanoparticles were utilized as a novel ratiometric photoluminescence (PL) nanosensor for extremely sensitive and selective detection of I(-) and S(2-) ions. The AgNCs were prepared in situ on the silica nanoparticles through polyethyleneimine (PEI) template approach. While dual PL emissions of AgNCs (at 500 nm) and luminescent silica nanoparticles (at 602 nm) formed the basis for the ratiometric sensing...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916105/selective-imaging-of-cancer-cells-with-a-ph-activatable-lysosome-targeting-fluorescent-probe
#18
Rongguang Shi, Lu Huang, Xiaoxue Duan, Guohao Sun, Gui Yin, Ruiyong Wang, Jun-Jie Zhu
Fluorescence imaging with tumor-specific fluorescent probe has emerged as a tool to aid surgeons in the identification and removal of tumor tissue. We report here a new lysosome-targeting fluorescent probe (NBOH) with BODIPY fluorephore to distinguish tumor tissue out of normal tissue based on different pH environment. The probe exhibited remarkable pH-dependent fluorescence behavior in a wide pH range from 3.0 to 11.0, especially a sensitive pH-dependent fluorescence change at pH range between 3.5 and 5.5, corresponding well to the acidic microenvironment of tumor cells, in aqueous solution...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916104/highly-selective-and-sensitive-visualization-and-identification-of-glycoproteins-using-multi-functionalized-soluble-dendrimer
#19
Tiantian Li, Zhenlong Yu, Liyuan Zhang, Chao Wang, Sa Deng, Xiaokui Huo, Xiangge Tian, Baojing Zhang, Xiaochi Ma
Glycoproteins are the most important and complex group of posttranslational modifications known in proteins. Many clinical biomarkers and therapeutic targets in cancer are glycoproteins. However, the isolation of glyco-specific antibodies and their poor stability remains a significant challenge in analytical method and diagnostic development. In this work, for the first time, we present a technology for highly efficient and selective glycosylation analysis on membrane without the use of glyco-specific antibodies...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916103/controlled-synchronized-actuation-of-microdroplets-by-gravity-in-a-superhydrophobic-3d-printed-device
#20
P E Oomen, J P S H Mulder, E Verpoorte, R D Oleschuk
Droplet manipulation over open surfaces allows one to perform assays with a large degree of control and high throughput, making them appealing for applications in drug screening or (bio)analysis. However, the design, manufacturing and operation of these systems comes with high technical requirements. In this study we employ a commercial, low-friction, superhydrophobic coating, Ultra-Ever Dry(®), on a 3D-printed microfluidic device. The device features individual droplet compartments, which allow the manipulation of discrete droplets (10-50 μL) actuated by gravity alone...
October 2, 2017: Analytica Chimica Acta
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