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Analytica Chimica Acta

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https://www.readbyqxmd.com/read/28433062/electrospun-nafion-polyacrylonitrile-nanofibers-as-an-ion-exchange-ultrathin-layer-chromatographic-stationary-phase
#1
Yanhui Wang, Susan V Olesik
An ion-exchange method to separate charged biomolecules on ultrathin layer chromatographic (UTLC) plates using electrospun Nafion-Polyacrylonitrile (PAN) nanofibers as the stationary phase is described. Sulfonate groups on Nafion provide the ion-exchange sites. The addition of PAN (a higher molecular weight polymer than Nafion) was used to facilitate the nanofiber formation process using electrospinning. Electrospinning parameters and separation conditions were optimized using fractional factorial design and response surface methodology...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28433061/graphene-coated-polymeric-anion-exchangers-for-ion-chromatography
#2
Kai Zhang, Minyi Cao, Chaoyan Lou, Shuchao Wu, Peimin Zhang, Mingyu Zhi, Yan Zhu
Carbonaceous stationary phases have gained much attention for their peculiar selectivity and robustness. Herein we report the fabrication and application of a graphene-coated polymeric stationary phase for anion exchange chromatography. The graphene-coated particles were fabricated by a facile evaporation-reduction method. These hydrophilic particles were proven appropriate substrates for grafting of hyperbranched condensation polymers (HBCPs) to make pellicular anion exchangers. The new phase was characterized by zeta potentials, Fourier transform infrared spectroscopy, thermogravimetry and scanning electron microscope...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28433060/enhanced-photoresponsive-polyethyleneimine-citric-acid-co-carbonized-dots-for-facile-and-selective-sensing-and-intracellular-imaging-of-cobalt-ions-at-physiologic-ph
#3
Wen-Sheng Zou, Qing-Chun Zhao, Jun Zhang, Xiao-Ming Chen, Xiu-Fang Wang, Lin Zhao, Shao-Hua Chen, Ya-Qin Wang
Whether as an important biological element or as a radioactive source/medicine, the monitoring of trace levels of cobalt ions (Co) has become a non-negligible factor for human health and green environment. Current technologies for the detection of Co are cost-expensive and time-consuming, and require cumbersome sample pretreatment process. Herein a novel sensing platform has been developed for Co detection based on the quenching of the enhanced fluorescence signal of polyamine functionalized C-dots. Amine groups at the surface of the C-dots can capture Zn(2+)/Cd(2+) to form coordination compound, which can inhibit the photoinduced electron transfer pathways of C-dots and then induce the fluorescence enhancement of the C-dots by ∼80% margin...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28433059/an-entropy-driven-signal-amplifying-strategy-for-real-time-monitoring-of-dna-methylation-process-and-high-throughput-screening-of-methyltransferase-inhibitors
#4
Siyi Chen, Huan Ma, Wang Li, Zhou Nie, Shouzhuo Yao
Based on the entropy-driven toehold-mediated hairpin displacement (ETHDA), a facile and sensitive one-step fluorescence sensing platform has been proposed for the evaluation DNA methylation process catalyzed by methyltransferase (MTase). In this designed system, a hairpin probe is methylated by DNA adenine methylation (Dam) MTase and cleaved by DpnI endonuclease successively, liberating a catalyzer strand to initiate the signal amplification. The fluorescence intensity is increasing upon the catalyzer strand triggered circulating procedure of the ETHDA process...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28433058/ultrathin-au-nanowires-assisted-magnetic-graphene-silica-zic-hilic-composites-for-highly-specific-enrichment-of-n-linked-glycopeptides
#5
Fenglong Jiao, Fangyuan Gao, Heping Wang, Yulin Deng, Yangjun Zhang, Xiaohong Qian, Yukui Zhang
Protein glycosylation has been proven to participate in a variety of complex biological processes; however, the low abundance of glycopeptides in natural samples makes it essential to develop methods to isolate and enrich glycopeptides. In this study, a novel ultrathin Au nanowire assisted zwitterionic hydrophilic magnetic graphene oxide (GO-Fe3O4/SiO2/AuNWs/L-Cys) was synthesized with the good biocompatibility of GO, strong magnetic responses of Fe3O4, large surface area of ultrathin Au nanowires and excellent hydrophilicity of L-Cys via four simple and rapid steps...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28433057/low-cost-humic-acid-bonded-silica-as-an-effective-solid-phase-extraction-sorbent-for-convenient-determination-of-aflatoxins-in-edible-oils
#6
Neng-Zhi Zhou, Ping Liu, Xiao-Chuan Su, Yan-Hua Liao, Ning-Sheng Lei, Yong-Hong Liang, Shao-Huan Zhou, Wen-Si Lin, Jie Chen, Yu-Qi Feng, Yang Tang
Aflatoxins (AFs) are highly toxic, mutagenic, carcinogenic, and teratogenic secondary metabolites produced by the toxigenic fungi Aspergillus flavus and Aspergillus parasiticus. AFs tend to contaminate a wide range of foods which is a serious and recurring food safety problem worldwide. Currently, immunoaffinity chromatography (IAC) has become the most conventional sample clean-up method for determining AFs in foodstuffs. However, IAC method is limited in the large-scale food analysis because it requires the use of expensive disposable cartridges and the IA procedure is time-consuming...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28433056/discriminative-sensing-of-dopa-enantiomers-by-cyclodextrin-anchored-graphene-nanohybrids
#7
Salih Ates, Erhan Zor, Ilker Akin, Haluk Bingol, Sabri Alpaydin, Emine G Akgemci
Discriminative sensing of chiral species with a convenient and robust system is a challenge in chemistry, pharmaceutics and particularly in biomedical science. Advanced nanohybrid materials for discrimination of these biologically active molecules can be developed by combination of individual obvious advantages of different molecular scaffolds. Herein, we report on the comparison of the performance of cyclodextrin functionalized graphene derivatives (x-CD/rGO, x: α-, β-, γ-) for discrimination of DOPA enantiomers...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28433055/pyrenyl-carbon-nanostructures-for-ultrasensitive-measurements-of-formaldehyde-in-urine
#8
Gayan Premaratne, Sabrina Farias, Sadagopan Krishnan
Measurement of ultra-low (e.g., parts-per-billion) levels of small-molecule markers in body fluids (e.g., serum, urine, saliva) involves a considerable challenge in view of designing assay strategies with sensitivity and selectivity. Herein we report for the first time an amperometric nano-bioelectrode design that uniquely combines 1-pyrenebutyric acid units pi-pi stacked with carboxylated multiwalled carbon nanotubes on the surface of gold screen printed electrodes for covalent attachment of NAD(+) dependent formaldehyde dehydrogenase (FDH)...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28433054/technical-aspects-and-challenges-of-colorimetric-detection-with-microfluidic-paper-based-analytical-devices-%C3%AE-pads-a-review
#9
REVIEW
Giorgio Gianini Morbioli, Thiago Mazzu-Nascimento, Amanda M Stockton, Emanuel Carrilho
Paper-based devices are a leading alternative among the main analytical tools for point-of-care testing, due to their portability, low-cost, and ease-of-use. Colorimetric readouts are the most common method of detection in these microfluidic devices, enabling qualitative, semi-quantitative and fully quantitative analysis of multiple analytes. There is a multitude of ways to obtain a colorimetric output in such devices, including nanoparticles, dyes, redox and pH indicators, and each has unique drawbacks and benefits...
June 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411633/proximity-hybridization-regulated-catalytic-dna-hairpin-assembly-for-electrochemical-immunoassay-based-on-in-situ-dna-template-synthesized-pd-nanoparticles
#10
Fuyi Zhou, Yao Yao, Jianjun Luo, Xing Zhang, Yu Zhang, Dengyang Yin, Fenglei Gao, Po Wang
Novel hybridization proximity-regulated catalytic DNA hairpin assembly strategy has been proposed for electrochemical immunoassay based on in situ DNA template-synthesized Pd nanoparticles as signal label. The DNA template-synthesized Pd nanoparticles were characterized with atomic force microscopic and X-ray photoelectron spectroscopy. The highly efficient electrocatalysis by DNA template synthesized Pd nanoparticles for NaBH4 oxidation produced an intense detection signal. The label-free electrochemical method achieved the detection of carcinoembryonic antigen (CEA) with a linear range from 10(-15) to 10(-11) g mL(-1) and a detection limit of 0...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411632/an-ultra-specific-and-sensitive-sandwich-elisa-for-imatinib-using-two-anti-imatinib-antibodies
#11
Tetsuya Saita, Yuta Yamamoto, Kazuhisa Hosoya, Yutaro Yamamoto, Sakiko Kimura, Yutaka Narisawa, Masashi Shin
The development of an immunoassay for a low-molecular-weight drug first requires the identification of specific antibodies that do not cross-react with the drug's metabolites. If two antibodies can simultaneously recognize the entire structure of the drug, we can then utilize them to establish an ultra-specific sandwich ELISA, free from interference due to the metabolic products of the drug. This paper reports an ultra-specific and sensitive sandwich ELISA for determination of the tyrosine kinase inhibitor imatinib using two anti-imatinib antibodies...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411631/escherichia-coli-adhesive-coating-as-a-chiral-stationary-phase-for-open-tubular-capillary-electrochromatography-enantioseparation
#12
Qifeng Fu, Kailian Zhang, Die Gao, Lujun Wang, Fengqing Yang, Yao Liu, Zhining Xia
Bacteria, the microorganism with intrinsic chirality, have numerous fascinating chiral phenomena such as various chirality-triggered biological processes and behaviors. Herein, bacteria were firstly explored as novel chiral stationary phases in open-tubular capillary electrochromatography (OT-CEC) for enantioseparation of fluoroquinolone enantiomers and simultaneous separation of six fluoroquinolone antibiotics. The model strain, i.e. non-pathogenic Escherichia coli (E. coli) DH5α, was adhered onto the inner surface of positively charged polyethyleneimine (PEI) modified capillaries based on the bacterial adhesion characteristics and strong electrostatic interaction...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411630/an-immunochromatographic-assay-for-carcinoembryonic-antigen-on-cotton-thread-using-a-composite-of-carbon-nanotubes-and-gold-nanoparticles-as-reporters
#13
Xiaobo Jia, Tingting Song, Yan Liu, Lili Meng, Xun Mao
This paper describes a low-cost, sensitive, visual and rapid immunochromatographic assay method on cotton thread for carcinoembryonic antigen (CEA) detection by using novel carbon nanotube/gold nanoparticles (CNT/GNPs) nanocomposite reporter probe. CEA, a lung cancer protein biomarker, was used as analyte to demonstrate the principle of the immunochromatographic assay on cotton thread biosensor. In the presence of target CEA, the decreasing aggregation amount of CNT/GNPs nanocomposite reporter probes on the test zone induced directly readout by naked eye...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411629/fluorescence-probe-for-hypochlorous-acid-in-water-and-its-applications-for-highly-lysosome-targetable-live-cell-imaging
#14
Xiaojie Jiao, Chang Liu, Qing Wang, Kun Huang, Song He, Liancheng Zhao, Xianshun Zeng
Hypochloric acid (HOCl) plays important roles in cell signaling and homeostasis, such as anti-inflammation and immune regulation, pathogen response and so on. Accordingly, direct detection of HOCl at the organelle level is important for investigation of the complex contributions of HOCl to human health. In the present study, a water soluble lysosome-targeting fluorescent probe Lyso-1 bearing a hydrazone moiety as a HOCl-responsive site and a morpholine unit as a lysosomal-targeting group has been synthesized and evaluated for its ability to image lysosomal HOCl...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411628/accurate-and-sensitive-determination-of-molar-fractions-of-13-c-labeled-intracellular-metabolites-in-cell-cultures-grown-in-the-presence-of-isotopically-labeled-glucose
#15
Mario Fernández-Fernández, Pablo Rodríguez-González, David Hevia Sánchez, Pedro González-Menéndez, Rosa M Sainz Menéndez, J Ignacio García Alonso
This work describes a methodology based on multiple linear regression and GC-MS for the determination of molar fractions of isotopically-labeled intracellular metabolites in cell cultures. Novel aspects of this work are: i) the calculation of theoretical isotopic distributions of the different isotopologues from an experimentally measured value of % 13C enrichment of the labeled precursor ii) the calculation of the contribution of lack of mass resolution of the mass spectrometer and different fragmentation mechanism such as the loss or gain of hydrogen atoms in the EI source to measure the purity of the selected cluster for each metabolite and iii) the validation of the methodology not only by the analysis of gravimetrically prepared mixtures of isotopologues but also by the comparison of the obtained molar fractions with experimental values obtained by GC-Combustion-IRMS based on (13)C/(12)C isotope ratio measurements...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411627/combination-of-electrospray-ionization-atmospheric-pressure-photoionization-and-laser-desorption-ionization-fourier-transform-ion-cyclotronic-resonance-mass-spectrometry-for-the-investigation-of-complex-mixtures-application-to-the-petroleomic-analysis-of-bio
#16
Jasmine Hertzog, Vincent Carré, Yann Le Brech, Colin Logan Mackay, Anthony Dufour, Ondřej Mašek, Frédéric Aubriet
The comprehensive description of complex mixtures such as bio-oils is required to understand and improve the different processes involved during biological, environmental or industrial operation. In this context, we have to consider how different ionization sources can improve a non-targeted approach. Thus, the Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been coupled to electrospray ionization (ESI), laser desorption ionization (LDI) and atmospheric pressure photoionization (APPI) to characterize an oak pyrolysis bio-oil...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411626/quantitative-determination-of-polysulfide-in-albumins-plasma-proteins-and-biological-fluid-samples-using-a-novel-combined-assays-approach
#17
Mayumi Ikeda, Yu Ishima, Akitomo Shibata, Victor T G Chuang, Tomohiro Sawa, Hideshi Ihara, Hiroshi Watanabe, Ming Xian, Yuya Ouchi, Taro Shimizu, Hidenori Ando, Masami Ukawa, Tatsuhiro Ishida, Takaaki Akaike, Masaki Otagiri, Toru Maruyama
Hydrogen sulfide (H2S) signaling involves polysulfide (RSSnSR') formation on various proteins. However, the current lack of sensitive polysulfide detection assays poses methodological challenges for understanding sulfane sulfur homeostasis and signaling. We developed a novel combined assay by modifying Sulfide Antioxidant Buffer (SAOB) to produce an "Elimination Method of Sulfide from Polysulfide" (EMSP) treatment solution that liberates sulfide, followed with methylene blue (MB) sulfide detection assay. The combined EMSP-MB sulfide detection assay performed on low molecular weight sulfur species showed that sulfide was produced from trisulfide compounds such as glutathione trisulfide and diallyl trisulfide, but not from the thiol compounds such as cysteine, cystine and glutathione...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28411625/rapid-imaging-and-detection-of-circulating-tumor-cells-using-a-wide-field-fluorescence-imaging-system
#18
Tomoko Yoshino, Kaori Takai, Ryo Negishi, Tatsuya Saeki, Hisashige Kanbara, Yoshihito Kikuhara, Tadashi Matsunaga, Tsuyoshi Tanaka
Circulating tumor cells (CTCs) provide potentially accessible in vivo sources of metastatic cancer cells. As such, considerable focus has been placed on analyzing the genetics of single-CTCs. Prior to these analyses, however, CTCs must first be detected within the blood samples of cancer patients. Current methods for detection of CTCs by fluorescence microscopy require the analysis of hundreds of images per blood sample, making this a time-consuming process that creates a bottleneck in CTC analysis. In this study, we therefore developed a wide-field fluorescence imaging system for rapid CTC detection...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28395779/a-novel-near-infrared-fluorescent-probe-for-sensitive-detection-of-%C3%AE-galactosidase-in-living-cells
#19
Jingtuo Zhang, Cong Li, Colina Dutta, Mingxi Fang, Shuwei Zhang, Ashutosh Tiwari, Thomas Werner, Fen-Tair Luo, Haiying Liu
A novel near-infrared fluorescent probe for β-galactosidase has been developed based on a hemicyanine skeleton, which is conjugated with a d-galactose residue via a glycosidic bond. The probe serves as a substrate of β-galactosidase and displays rapid and sensitive turn-on fluorescent responses to β-galactosidase in aqueous solution. A 12.8-fold enhancement of fluorescence intensity at 703 nm was observed after incubation of 10 nM of β-galactosidase with 5 μM probe for 10 min. The probe can sensitively detect as little as 0...
May 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28395778/an-on-off-on-fluorescent-nanoprobe-for-recognition-of-chromium-vi-and-ascorbic-acid-based-on-phosphorus-nitrogen-dual-doped-carbon-quantum-dot
#20
Xiaojuan Gong, Yang Liu, Zhenhua Yang, Shaomin Shuang, Zeyu Zhang, Chuan Dong
Chromium (VI) [Cr(VI)] is a harsh environmental contaminates and has been proved to be highly toxic, carcinogenic and mutagenic. Therefore, developing an inexpensive, good selective and highly sensitive nanoprobe for the detection of Cr(VI) is in urgent demand. Recently, the highly fluorescent carbon quantum dots (CQDs) have been successfully utilized as efficient fluorescent nanoprobes for the detection of ions, pH and molecular substances. In this work, an "on-off" fluorescence phosphorus/nitrogen dual-doped CQDs (PNCQDs) probe was developed for the determination of Cr(VI) based on inner filter effect (IFE)...
May 22, 2017: Analytica Chimica Acta
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