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American Journal of the Medical Sciences

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https://www.readbyqxmd.com/read/30219170/central-retinal-artery-occlusion-following-hyaluronic-acid-fillers-injection
#1
LETTER
Ji-Long Hao, Om Prakash Pant, Cheng-Wei Lu
No abstract text is available yet for this article.
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219169/kallmann-syndrome-with-micropenis
#2
LETTER
Chia-Po Fu, I-Te Lee
No abstract text is available yet for this article.
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219168/timing-of-repeated-lactate-measurement-in-patients-with-septic-shock-at-the-emergency-department
#3
Seung Mok Ryoo, Ryeok Ahn, JungBok Lee, Chang Hwan Sohn, Dong Woo Seo, Jin Won Huh, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Won Young Kim
BACKGROUND: The objective of this study was to evaluate the prognostic value of lactate levels during the first 12 hours after shock development and to identify the optimal timing for repeated lactate measurements in patients with septic shock. METHODS: We conducted a retrospective cohort study using a prospective data registry, and enrolled 2,226 consecutive adult patients with septic shock between January 2010 and December 2015. Blood lactate was measured at shock development, and after 2, 4, 6 and 12 hours (T0 , T2 , T4 , T6 and T12 ) during protocol-driven resuscitation bundle therapy...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219167/the-dust-bowl-in-the-us-an-analysis-based-on-current-environmental-and-clinical-studies
#4
EDITORIAL
Robert Alexander, Connie Nugent, Kenneth Nugent
The Dust Bowl occurred in the Central Plains states in the United States between 1930 and 1940. Prolonged drought, intense recurrent dust storms and economic depression had profound effects on human welfare. The causes included increased farming on marginal land, poor land management, and prolonged drought. There was a significant increase in the number of cases of measles, increased hospitalization for respiratory disorders and increased infant and overall mortality in Kansas during the Dust Bowl. Recent scientific studies have demonstrated that dust transmits measles virus, influenza virus and Coccidioides immitis, and that mortality in the United States increases following dust storms with 2-3-day lag periods...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219166/an-offer-we-cannot-refuse-cell-free-dna-as-a-novel-biomarker-of-myocardial-infarction
#5
EDITORIAL
Daria V Ilatovskaya, Kristine Y DeLeon-Pennell
No abstract text is available yet for this article.
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219165/does-timing-matter-using-lactate-to-predict-outcomes-in-sepsis
#6
EDITORIAL
Michael Baram, Bharat Awsare
No abstract text is available yet for this article.
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219164/experiential-learning-in-undergraduate-education-doing-and-reflecting
#7
LETTER
Veronica M Roman
No abstract text is available yet for this article.
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219163/experiential-learning-in-medical-education
#8
EDITORIAL
Urvashi Vaid
No abstract text is available yet for this article.
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219162/the-summer-enrichment-program-a-multidimensional-experiential-enriching-experience-for-junior-medical-students
#9
LETTER
Abdulhadi A AlAmodi, Ahmed Abu-Zaid, Abdulaziz M Eshaq, Khaled Al-Kattan
No abstract text is available yet for this article.
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219161/recurrent-severe-hypoinsulinemic-hypoglycemia-responsive-to-temozolomide-and-bevacizumab-in-a-patient-with-doege-potter-syndrome
#10
REVIEW
Amie A Ogunsakin, Holly L Hilsenbeck, David C Portnoy, Ebenezer A Nyenwe
Nonislet cell tumor hypoglycemia is rare. We highlight the diagnosis and treatment of recurrent severe hypoglycemia in a 49-year-old woman with malignant solitary fibrous tumor of the pleura (Doege-Potter syndrome). The clinical, laboratory and radiologic findings of the case are presented and a brief literature review is provided. Of note, imaging studies showed a large mass in the right hemithorax and pathology and immunehistochemical stains confirmed a malignant solitary fibrous tumor of the pleura. She was a poor surgical candidate owing to a large tumor burden...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219160/evaluation-and-management-of-gross-hematuria-in-autosomal-dominant-polycystic-kidney-disease-a-point-of-care-guide-for-practicing-internists
#11
REVIEW
Bhavna Bhasin, Mohammed Alzubaidi, Juan Carlos Q Velez
Gross hematuria is common in autosomal dominant polycystic kidney disease (ADPKD). It is an alarming symptom and may be the first manifestation of ADPKD. Cyst hemorrhage is a frequent cause of hematuria in ADPKD while other differential diagnoses include cyst infection, urinary tract infection, renal stones and an underlying malignancy. Knowledge of the precipitating factors and clinical presentation of these conditions will help practicing internists in performing an appropriate evaluation and management of these entities and their complications, as well as executing timely referrals to subspecialists when indicated...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219159/silent-information-regulator-1-negatively-regulates-atherosclerotic-angiogenesis-via-mammalian-target-of-rapamycin-complex-1-signaling-pathway
#12
Runtai Chen, Zhenchun Huang, Junyi Wang, Xiaoying Chen, Yucai Fu, Wei Wang
BACKGROUND: This study aimed to investigate the interactions between silent information regulator 1 (SIRT1) and mammalian target of rapamycin (mTOR) in intraplaque angiogenesis and their potential mechanisms through in vivo and in vitro studies. METHODS: An atherosclerosis model was established in 12 rabbits on a high-cholesterol diet. The rabbits were equally divided into 3 groups: a control group (high-lipid diet), RAP group (high-lipid diet supplemented with rapamycin) and RAP + NAM group (high-lipid diet supplemented with rapamycin and nicotinamide)...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219158/gender-specific-association-of-leptin-and-adiponectin-genes-with-multiple-sclerosis
#13
Marziyeh Yousefian, Reza Nemati, Gholamreza Daryabor, Naser Gholijani, Alireza Nikseresht, Afshin Borhani-Haghighi, Eskandar Kamali-Sarvestani
BACKGROUND: Adipocytokines such as leptin (LEP) and adiponectin (ADIPOQ) represent a link between metabolism, nutritional status and immune responses. The present study aimed to determine the possible association between single nucleotide polymorphisms of LEP and ADIPOQ genes with multiple sclerosis (MS). MATERIALS AND METHODS: Single nucleotide polymorphisms in LEP (rs2167270 or 19G > A and rs7799039 or -2,548G > A) and ADIPOQ (rs1501299 or +276G > T and rs266729 or -11,377C > G) were genotyped in 305 patients and 255 healthy individuals using polymerase chain reaction-restriction fragment length polymorphism...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219157/tricuspid-regurgitation-pressure-gradient-as-a-useful-predictor-of-adverse-cardiovascular-events-and-all-cause-mortality-in-patients-with-atrial-fibrillation
#14
Po-Chao Hsu, Wen-Hsien Lee, Chun-Yuan Chu, Wei-Chung Tsai, Hung-Hao Lee, Chee-Siong Lee, Hsueh-Wei Yen, Tsung-Hsien Lin, Wen-Chol Voon, Wen-Ter Lai, Sheng-Hsiung Sheu, Ho-Ming Su
BACKGROUND: Tricuspid regurgitation pressure gradient (TRPG) is reportedly a predictor of cardiovascular (CV) mortality in patients without atrial fibrillation (AF); its relationship with cardiac outcomes in patients with AF has never been evaluated. This study aimed to examine the ability of TRPG to predict CV events and all-cause mortality in patients with AF. MATERIALS AND METHODS: Comprehensive echocardiography was performed in 155 patients with persistent AF...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219156/hepatitis-b-virus-infection-is-independently-associated-with-advanced-colorectal-adenoma
#15
Su Hwan Kim, Ji Won Kim, Kook Lae Lee, Seohui Lee, Seong-Joon Koh, Ji Bong Jeong, Byeong Gwan Kim
BACKGROUND: Studies on the association of chronic hepatitis B virus (HBV) infection with colonic neoplasm are rare. We aimed to investigate the association between chronic HBV infection and the development of colonic adenoma. MATERIALS AND METHODS: One hundred thirty-three patients with chronic HBV infection who underwent colonoscopic examination, were enrolled. A healthy HBV-uninfected group was matched with the HBV group. Those with a previous history of colorectal cancer, inflammatory bowel diseases or colorectal surgery were excluded from both HBV and HBV-uninfected groups...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219155/modifiable-predictors-of-in-hospital-mortality-in-patients-undergoing-transcatheter-aortic-valve-replacement
#16
Oluwaseun A Akinseye, Muhammad Shahreyar, Chioma C Nwagbara, Mannu Nayyar, Salem A Salem, Mohamed Morsy, Rami N Khouzam, Uzoma N Ibebuogu
BACKGROUND: Transcatheter aortic valve replacement (TAVR) has become an acceptable therapy for patients with severe aortic valve stenosis at high or prohibitive surgical risk. Attempts are ongoing to validate risk prediction models for in-hospital mortality after TAVR. Our aim was to define modifiable risk factors predictive of in-hospital mortality after TAVR. METHODS: We identified patients who underwent TAVR from the 2012 database of the National Inpatient Sample...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219154/braf-v600e-gene-mutation-is-associated-with-bilateral-malignancy-of-papillary-thyroid-cancer
#17
Zhuoran Liu, Tian Lv, Cong Xie, Zhongmin Di
BACKGROUND: Papillary thyroid cancer (PTC) is the most prevalent type of thyroid cancer, which is the most common type of endocrine malignancy. Stratification and personalized surgical management of PTC patients are the major challenges for thyroid surgeons. Though BRAF V600E gene mutation presents in 50-70% of PTCs, it is unclear whether BRAF V600E testing could contribute to clinical practice. Therefore, this study investigated the association between BRAF V600E mutation and clinicopathologic features of PTC to evaluate the benefit of BRAF V600E testing to clinical management of PTC...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219153/correlations-of-circulating-cell-free-dna-with-clinical-manifestations-in-acute-myocardial-infarction
#18
Jin Xie, Jiawei Yang, Pei Hu
BACKGROUND: The objective of the study was to examine the potential use of circulating cell free DNA (cfDNA) in acute myocardial infarction (AMI) patients and correlate it with clinical features. Serial monitoring was conducted to assess any associations to disease. METHODS: Quantification of cfDNA was performed on 130 cardiovascular disease (CVD) patients as well as 30 healthy volunteers. Serial samplings were conducted using PicoGreen dsDNA assay. Of the 130 patients with CVD, 100 had an AMI and measurements were taken during treatment...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219152/coding-and-noncoding-variants-in-cfh-act-synergistically-for-complement-activation-in-immunoglobulin-a-nephropathy
#19
Wei-Yi Guo, Qing-Zhen Liu, Li Zhu, Zeng-Yan Li, Si-Jun Meng, Su-Fang Shi, Li-Jun Liu, Ji-Cheng Lv, Ping Hou, Hong Zhang
BACKGROUND: In immunoglobulin A nephropathy (IgAN), complement activation occurs in both the systemic circulation and in situ (glomerular). A recent IgAN-genome-wide association study (GWAS) identified 1q32 as an IgAN susceptible locus that contained the complement regulatory protein coding gene complement factor H (CFH). Here, we explored the combined genetic effects of coding and noncoding variants in CFH, rs6677604 and rs800292 on complement activation in IgAN. METHODS: In total, 1,194 IgAN patients and 900 healthy controls who were the same as the Beijing Discovery Cohort in our recent IgAN-GWAS were recruited...
August 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/30219151/reduced-stroke-after-transcatheter-patent-foramen-ovale-closure-a-systematic-review-and-meta-analysis
#20
Chikezie Alvarez, Waqas Javed Siddiqui, Sandeep Aggarwal, Syed Farhan Hasni, Shelly Hankins, Howard Eisen
BACKGROUND: Recent randomized control trials (RCTs) have suggested benefit with transcatheter patent foramen ovale (PFO) closure plus antiplatelet therapy over medical treatment alone for secondary stroke prevention. MATERIAL AND METHODS: Data sources: we searched PubMed and Ovid MEDLINE from the inception until November 10, 2017 for RCTs comparing TPFO closure to medical therapy in patients with a PFO and a history of cryptogenic stroke. RESULTS: Five RCTs with 3,627 patients (TPFO closure = 1,829 versus medical therapy =1,798) were included...
August 2018: American Journal of the Medical Sciences
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