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American Journal of the Medical Sciences

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https://www.readbyqxmd.com/read/29289273/vascular-and-splenic-abnormalities-in-heterotaxy-syndrome
#1
LETTER
Kirtipal Bhatia, Abhishek Maiti, Saurav Chatterjee
No abstract text is available yet for this article.
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289272/when-patient-family-expectations-and-hospital-protocol-conflict
#2
EDITORIAL
Orel Shuker, Mogher Khamaisi
No abstract text is available yet for this article.
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289271/congenital-descending-aorta-pulmonary-vein-fistula
#3
Tingting Wu, Yiming Yu, Yun Zhang, Zaichun Deng
No abstract text is available yet for this article.
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289270/squamous-cell-carcinoma-of-the-pancreas
#4
Erica Lin, Hima Veeramachaneni, Benyam Addissie, Amindra Arora
No abstract text is available yet for this article.
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289269/myocardial-infarction-secondary-to-blunt-chest-trauma
#5
Tariq S Marroush, Amreeta V Sharma, Louis D Saravolatz, Robert Takla, Howard S Rosman
Myocardial infarction (MI) following blunt chest trauma is rare, but potentially fatal. We treated a young patient for acute MI after falling chest-first on ice while playing hockey. Coronary artery bypass grafting (CABG) was performed after percutaneous stenting attempts were unsuccessful. By reviewing the related literature, we found 179 cases, the majority of which affected young males following road accidents. Left anterior descending artery was most frequently affected followed by right coronary artery particularly in their proximal thirds...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289268/rhabdomyolysis-associated-acute-kidney-injury-with-normal-creatine-phosphokinase
#6
Faisal Kamal, Lindsay Snook, Jagannath H Saikumar
Rhabdomyolysis is a syndrome characterized by the breakdown of skeletal muscle and leakage of intracellular myocyte contents, such as creatine phosphokinase (CPK) and myoglobin, into the interstitial space and plasma resulting in acute kidney injury (AKI). Elevated CPK of at least 5 times the upper limit of normal is an important diagnostic marker of Rhabdomyolysis. We present a case of rhabdomyolysis with severe AKI with a normal CPK at presentation. A 32-year-old man presented with acute respiratory failure and AKI after an overdose of recreational drugs...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289267/role-of-bone-marrow-derived-mesenchymal-stem-cells-and-the-protective-effect-of-silymarin-in-cisplatin-induced-acute-renal-failure-in-rats
#7
Mohamed El-Tantawy Ibrahim, Eman El Bana, Hanan I El-Kerdasy
BACKGROUND: Cisplatin is a highly effective antitumor agent whose clinical application is limited by its nephrotoxicity, which is associated with high mortality and morbidity rates. We aimed to study the protective role of silymarin and mesenchymal stem cells as a therapeutic tool of cisplatin nephrotoxicity. MATERIALS AND METHODS: We injected rats with cisplatin in a dose of 5mg/kg body weight for 5 days to induce acute renal failure (ARF). Silymarin was administrated 6 hours before cisplatin injection and mesenchymal stem cells were injected 24 hours after cisplatin-induced ARF...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289266/is-myc-an-important-biomarker-myc-expression-in-immune-disorders-and-cancer
#8
REVIEW
Shivtia Trop-Steinberg, Yehudit Azar
The proto-oncogene Myc serves as a paradigm for understanding the dynamics of transcriptional regulation. Myc protein has been linked to immune dysfunction, cancer development and neoplastic transformation. We review recent research regarding functions of Myc as an important modulator in immune disorders, postallogeneic hematopoietic stem cell transplantation (HSCT) and several cancers. Myc overexpression has been repeatedly linked to immune disorders and specific cancers, such as myasthenia gravis, psoriasis, pemphigus vulgaris, atherosclerosis, long-term allogeneic survival among HSCT patients, (primary) inflammatory breast cancer, (primary) ovarian carcinoma and hematological malignancies: acute myeloid leukemia, chronic myelogenous leukemia, Hodgkin's lymphoma and diffuse large B-cell lymphoma...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289265/utility-of-serum-igg4-levels-in-a-multiethnic-population
#9
Ruyu Qi, Luke Y C Chen, Sujin Park, Robert Irvine, Michael A Seidman, John T Kelsall, David Collins, Vivian Yin, Graham W Slack, Andre Mattman, Eric Lam, Mollie N Carruthers
BACKGROUND: IgG4-related disease (IgG4-RD) is a recently recognized condition defined by characteristic histopathologic findings in affected organs. Serum IgG4 concentration is often but not always elevated. The sensitivity and specificity of serum IgG4 vary greatly across studies and has been anecdotally associated to ethnicity. Our study was conducted to investigate the difference in serum IgG4 levels between Asian and non-Asian patients with IgG4-RD. METHODS: This is a single-center retrospective study of 26 Asian and 10 non-Asian patients with histologically confirmed IgG4-RD...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289264/topical-treatment-of-degenerative-knee-osteoarthritis
#10
REVIEW
Zengdong Meng, Rongzhong Huang
This article reviews topical management strategies for degenerative osteoarthritis (OA) of the knee. A search of Pubmed, Embase and the Cochrane library using MeSH terms including "topical," "treatment," "knee" and "osteoarthritis" was carried out. Original research and review articles on the effectiveness and safety, recommendations from international published guidelines and acceptability studies of topical preparations were included. Current topical treatments included for the management of knee OA include topical nonsteroidal anti-inflammatory drugs, capsaicin, salicylates and physical treatments such as hot or cold therapy...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289263/longitudinal-changes-in-insulin-resistance-beta-cell-function-and-glucose-regulation-status-in-prediabetes
#11
Chul-Hee Kim, Hong-Kyu Kim, Eun-Hee Kim, Sung-Jin Bae, Jaewon Choe, Joong-Yeol Park
BACKGROUND: The changes in insulin resistance and insulin secretion and their association with changes in glucose regulation status in Asians with prediabetes remain uncertain. MATERIALS AND METHODS: We included Korean adults (aged 20-79 years) with prediabetes who underwent routine medical check-ups at a mean interval of 5 years. Prediabetes was defined as fasting plasma glucose (FPG) 5.6-6.9mmol/l or HbA1c 5.7-6.4% (39-46mmol/mol). Insulin resistance (HOMA-IR) and beta-cell function (HOMA-%B) indices were assessed by homeostasis model assessment...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289262/clinical-heterogeneity-of-interstitial-lung-disease-in-polymyositis-and-dermatomyositis-patients-with-or-without-specific-autoantibodies
#12
Fang Chen, Shanshan Li, Tao Wang, Jingli Shi, Guochun Wang
BACKGROUND: The aim of this study was to compare the heterogeneity of interstitial lung disease (ILD) in patients with polymyositis and dermatomyositis (PM/DM) according to serological type. METHODS: A total of 182 patients with PM/DM-ILD were observed retrospectively. Antiaminoacyl-tRNA synthetase (ARS) and antimelanoma differentiation-associated gene5 (MDA5) antibodies were screened using immunoblotting approach. The patients with ILD were divided into 3 groups: MDA5 (with anti-MDA5 antibody), ARS (with anti-ARS antibody) and MSN (without anti-MDA5 or anti-ARS antibody) group...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289261/r-wave-peak-time-at-lead-ii-in-adults-with-ventricular-premature-beats-bundle-branch-block-and-left-anterior-fascicular-block
#13
Min Yu, Tingting Chen, Shuang Hu, Shan Zou, Cantian Wang, Chujuan Zeng, Weijie Chen, Xuerui Tan
BACKGROUND: Recently, the R-wave peak time (RWPT) at lead II was reported to be a helpful and simple tool for differentiating wide QRS complex tachycardias with a RWPT ≥ 50ms for ventricular tachycardia diagnosis. Our previous study showed that the duration of RWPT at lead II in adults was ≈29ms. However, the effects of ventricular premature beats (VPBs), bundle branch block (BBB) or left anterior fascicular block (LAFB) on RWPT at lead II remain unknown. METHODS: The study was conducted in the First Affiliated Hospital of Shantou University Medical College in Southern China...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289260/relationship-between-serum-macrophage-migration-inhibitory-factor-level-and-insulin-resistance-high-sensitivity-c-reactive-protein-and-visceral-fat-mass-in-prediabetes
#14
Oktay Bilgir, Belma Gökçen, Ferda Bilgir, Aslı Guler, Mehmet Calan, Arif Yuksel, Behnaz Aslanıpour, Murat Akşit, Giray Bozkaya
BACKGROUND: Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered in subjects with prediabetes and also to determine the relationship between MIF and metabolic parameters as well as visceral fat mass. MATERIAL AND METHODS: This cross-sectional study included 40 subjects with prediabetes and 40 age-, body mass index (BMI)- and sex-matched subjects with normal glucose tolerance...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289259/cannabinoids-and-symptomatic-bradycardia
#15
Mark R Heckle, Mannu Nayyar, Scott E Sinclair, Karl T Weber
Cannabinoids, the bioactive components of marijuana, have adverse cardiovascular consequences, including symptomatic sinus bradycardia, sinus arrest and ventricular asystole. Physicians should be aware of these deleterious consequences which can appear in otherwise healthy persons who are chronic marijuana users.
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289258/identification-and-ablation-of-dormant-conduction-in-atrial-fibrillation-using-adenosine
#16
Faraz Khan Luni, Abdur Rahman Khan, Hemindermeet Singh, Haris Riaz, Sonia Ali Malik, Owais Khawaja, Talha Farid, Jennifer Cummings, Mohammed Taleb
BACKGROUND: Ablation is used for treatment of atrial fibrillation (AF) but recurrence is common. Dormant conduction is hypothesized to be responsible for these recurrences, and the role of adenosine in identification and ablation of these pathways is controversial with conflicting results on AF recurrence. MATERIALS AND METHODS: We conducted a meta-analysis for studies evaluating AF ablation and adenosine use. Included in the meta-analysis were human studies that compared ablation using adenosine or adenosine triphosphate (ATP) and reported freedom from AF in patients beyond a minimum follow-up of 6 months...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289257/the-association-between-major-depressive-disorder-and-outcomes-in-older-veterans-hospitalized-with-pneumonia
#17
Ami L DeWaters, Matthieu Chansard, Antonio Anzueto, Mary Jo Pugh, Eric M Mortensen
BACKGROUND: Major depressive disorder ("depression") has been identified as an independent risk factor for mortality for many comorbid conditions, including heart failure, cancer and stroke. Major depressive disorder has also been linked to immune suppression by generating a chronic inflammatory state. However, the association between major depression and pneumonia has not been examined. The aim of this study was to examine the association between depression and outcomes, including mortality and intensive care unit admission, in Veterans hospitalized with pneumonia...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289256/the-complexity-of-characteristics-diagnoses-and-treatment-of-older-patients-with-pulmonary-hypertension
#18
Hawa Edriss, Kavitha Selvan, Tatiana Denega, Terrance Rodrigues, Victor Test, Kenneth Nugent
BACKGROUND: Older patients with pulmonary hypertension (PH) are more likely to have complex comorbidity than younger patients with pulmonary arterial hypertension (PAH). The best approach to the evaluation and management of these patients is unclear. METHODS: We, retrospectively, reviewed the clinical records of patients older than 60 years referred for evaluation for PAH. We recorded patient demographics, comorbidity, functional classification (FC), right heart catheterization data, echocardiographic data, chest radiographic images and pulmonary function results...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29289255/pulmonary-hypertension-is-it-the-same-disease-in-young-versus-older-patients
#19
EDITORIAL
Karen A Fagan
No abstract text is available yet for this article.
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29208265/mulberry-shaped-gingival-overgrowth-induced-by-amlodipine-and-cyclosporine
#20
LETTER
Tanay Chaubal, Ranjeet Bapat
No abstract text is available yet for this article.
December 2017: American Journal of the Medical Sciences
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