journal
https://read.qxmd.com/read/38395293/angiographic-characteristics-of-patients-with-stemi-and-covid-19-insights-from-nacmi-registry
#21
JOURNAL ARTICLE
Payam Dehghani, Jyotpal Singh, G B John Mancini, Larissa Stanberry, Seth Bergstedt, Mina Madan, Catherine P Benziger, Nima Ghasemzadeh, Anna Bortnick, Rohan Kankaria, Cindy L Grines, Keshav Nayak, Mehmet Yildiz, M Chadi Alraies, Akshay Bagai, Rajan A G Patel, Shy Amlani, Brian C Case, Ron Waksman, Jay S Shavadia, Jay H Stone, Deepak Acharya, Nosheen Javed, Rodrigo Bagur, Ross Garberich, Santiago Garcia, Timothy D Henry
BACKGROUND: To date, there has been no independent core lab angiographic analysis of patients with COVID-19 and STEMI. The study characterized the angiographic parameters of patients with COVID-19 and STEMI. METHODS: Angiograms of patients with COVID-19 and STEMI from the North American COVID-19 Myocardial Infarction (NACMI) Registry were sent to a Core Laboratory in Vancouver, Canada. Culprit lesion(s), Thrombolysis In Myocardial Infarction (TIMI) flow, Thrombus Grade Burden (TGB), and percutaneous coronary intervention (PCI) outcome were assessed...
February 21, 2024: American Heart Journal
https://read.qxmd.com/read/38395292/regional-variation-in-cause-of-death-in-patients-with-type-2-diabetes-insights-from-exscel-cause-of-death-in-type-2-diabetes
#22
JOURNAL ARTICLE
Vishal N Rao, Abhinav Sharma, Amanda Stebbins, John B Buse, Brian G Katona, Neha J Pagidipati, Rury R Holman, Adrian Hernandez, Robert J Mentz, Renato D Lopes
AIMS: Type 2 diabetes (T2D) is a risk factor for cardiovascular and non-cardiovascular mortality. However, global distribution of cause-specific deaths in T2D is poorly understood. We characterized cause-specific deaths by geographic region among individuals with T2D at risk for cardiovascular disease (CVD). METHODS AND RESULTS: The international EXSCEL trial included 14,752 participants with T2D (73% with established CVD). We identified the proportion of deaths over 5-year follow-up attributed to cardiovascular and non-cardiovascular causes, and associated risk factors...
February 21, 2024: American Heart Journal
https://read.qxmd.com/read/38369219/landmark-trial-update-in-study-protocol
#23
JOURNAL ARTICLE
Akihiro Tobe, Yoshinobu Onuma, Osama Soliman, Andreas Baumbach, Patrick W Serruys
No abstract text is available yet for this article.
February 16, 2024: American Heart Journal
https://read.qxmd.com/read/38369218/variation-in-risk-adjusted-cardiac-intensive-care-unit-cicu-length-of-stay-and-the-association-with-in-hospital-mortality-an-analysis-from-the-critical-care-cardiology-trials-network-ccctn-registry
#24
JOURNAL ARTICLE
Daniel M Koerber, Jason N Katz, Erin Bohula, Jeong-Gun Park, Mark W Dodson, Daniel A Gerber, Dustin Hillerson, Shuangbo Liu, Matthew J Pierce, Rajnish Prasad, Scott W Rose, Pablo A Sanchez, Jeffrey Shaw, Jeffrey Wang, Jacob C Jentzer, L Kristin Newby, Lori B Daniels, David A Morrow, Sean van Diepen
BACKGROUND: Previous studies have suggested that there is wide variability in cardiac intensive care unit (CICU) length of stay (LOS); however, these studies are limited by the absence of detailed risk assessment at the time of admission. Thus, we evaluated inter-hospital differences in CICU LOS, and the association between LOS and in-hospital mortality. METHODS: Using data from the Critical Care Cardiology Trials Network (CCCTN) registry, we included 22,862 admissions between 2017 and 2022 from 35 primarily tertiary and quaternary CICUs that captured consecutive admissions in annual two-month snapshots...
February 16, 2024: American Heart Journal
https://read.qxmd.com/read/38367894/anatomic-and-physiologic-classification-of-adults-with-congenital-heart-disease-to-predict-adverse-outcomes-use-of-administrative-codes-compared-to-clinical-staging
#25
JOURNAL ARTICLE
Lindsey C Ivey, Attila Ahmad, Joy Chen, Fred H Rodriguez, Cheryl Raskind-Hood, Wendy M Book
BACKGROUND: The 2018 anatomic physiologic (AP) classification American Heart Association/American College of Cardiology (AHA/ACC) Guidelines for Adults with Congenital Heart Disease (ACHD) encompasses both native and post-operative anatomy and physiology to guide care management. As some physiologic conditions and post-operative states lack specific International Classification of Diseases (ICD) 9- Clinical Modification (CM) and 10-CM codes, an ICD code-based classification approximating the ACHD AP classification is needed for population-based studies...
February 15, 2024: American Heart Journal
https://read.qxmd.com/read/38367893/dapagliflozin-and-blood-pressure-in-patients-with-chronic-kidney-disease-and-albuminuria
#26
JOURNAL ARTICLE
Hiddo Jl Heerspink, Michele Provenzano, Priya Vart, Niels Jongs, Ricardo Correa-Rotter, Peter Rossing, Patrick B Mark, Roberto Pecoits-Filho, John Jv McMurray, Anna Maria Langkilde, David C Wheeler, Robert B Toto, Glenn M Chertow
BACKGROUND AND AIMS: Sodium-glucose cotransporter 2 inhibitors decrease blood pressure in patients with type 2 diabetes, but the consistency and magnitude of blood pressure lowering with dapagliflozin in patients with chronic kidney disease (CKD) is unknown. A pre-specified analysis of the DAPA-CKD trial to investigate the effect of dapagliflozin on systolic blood pressure (SBP) in patients with CKD, with and without type 2 diabetes was conducted. METHODS: A total of 4304 adults with baseline estimated glomerular filtration rate (eGFR) 25-75 mL/min/1...
February 15, 2024: American Heart Journal
https://read.qxmd.com/read/38365073/empagliflozin-to-elderly-and-obese-patients-with-increased-risk-of-developing-heart-failure-study-protocol-for-the-empire-prevent-trial-program
#27
JOURNAL ARTICLE
Camilla Fuchs Andersen, Julie Hempel Larsen, Jesper Jensen, Massar Omar, Nina Nouhravesh, Caroline Kistorp, Christian Tuxen, Finn Gustafsson, Filip K Knop, Julie Lyng Forman, Filip Soeskov Davidovski, Lars Thorbjørn Jensen, Kurt Højlund, Lars Køber, Lisbeth Antonsen, Mikael Kjær Poulsen, Morten Schou, Jacob Eifer Møller
INTRODUCTION: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have previously demonstrated cardioprotective properties in patients with type 2 diabetes, suggesting a preventive effect on heart failure (HF). The Empire Prevent trial program investigates the therapeutic potential for HF prevention by evaluating the cardiac, metabolic, and renal effects of the SGLT2 inhibitor empagliflozin in patients with increased risk of developing HF, but without diabetes or established HF. METHODS: The Empire Prevent trial program is an investigator-initiated, double-blind, randomized clinical trial program including elderly and obese patients (60-84 years, body mass index >28 kg/m2 ) with at least one manifestation of hypertension, cardiovascular or chronic kidney disease, but no history of diabetes or HF...
February 14, 2024: American Heart Journal
https://read.qxmd.com/read/38365072/out-of-pocket-prescription-drug-costs-for-adults-with-cardiovascular-risk-factors-under-amazon-s-direct-to-consumer-pharmacy-service
#28
JOURNAL ARTICLE
D August Oddleifson, Zhaonian Zheng, Rishi K Wadhera
BACKGROUND: US adults often overpay for generic prescription medications, which can lead to medication nonadherence that negatively impacts cardiovascular outcomes. As a result, new direct-to-consumer online medication services are growing in popularity nationwide. Amazon recently launched a $5/month direct-to-consumer medication subscription service (Amazon RxPass), but it is unclear how many US adults could save on out-of-pocket drug costs by using this new service. OBJECTIVES: To estimate out-of-pocket savings on generic prescription medications achievable through Amazon's new direct-to-consumer subscription medication service for adults with cardiovascular risk factors and/or conditions...
February 14, 2024: American Heart Journal
https://read.qxmd.com/read/38354997/gamification-augmented-home-based-exercise-for-peripheral-artery-disease-rationale-and-design-of-the-gamepad-study
#29
JOURNAL ARTICLE
Alexander C Fanaroff, Samantha Coratti, David Farraday, Laurie Norton, Charles Rareshide, Jingsan Zhu, Michael G Levin, Scott M Damrauer, Jay S Giri, Neel P Chokshi, Benjamin M Jackson, Mitesh S Patel
BACKGROUND: Supervised treadmill exercise improves walking performance, functional capacity, and quality of life in patients with peripheral artery disease (PAD). However, few patients with PAD are enrolled in supervised exercise programs, and there are a number of logistical and financial barriers to their participation. A home-based walking intervention is likely to be more accessible to patients with PAD, but no fully home-based walking program has demonstrated efficacy. Concepts from behavioral economics have been used to design scalable interventions that increase daily physical activity in patients with atherosclerotic vascular disease, but whether a similar program would be effective in patients with PAD is uncertain...
February 12, 2024: American Heart Journal
https://read.qxmd.com/read/38342392/should-ecg-criteria-for-low-qrs-voltage-lqrsv-be-specific-for-sex
#30
JOURNAL ARTICLE
Jason V Tso, Samuel Montalvo, Jeffrey Christle, David Hadley, Victor Froelicher
INTRODUCTION: Low QRS peak-to-nadir voltage (LQRSV) is associated with arrhythmogenic right ventricular cardiomyopathy (ARVC) and other cardiomyopathies. Recent studies have proposed criteria for LQRSV when screening athletes for cardiovascular disease. These criteria have not yet been evaluated in a large population of healthy young athletes. METHODS: 10,728 (42.5% female, 57.5% male, mean age 18.1±4.3 years) athletes who participated in mass ECG screenings between 2014-2021 at multiple sites across the United States including grade schools (11%), high schools (32%), colleges (50%), and professional athletic teams (6%) with digitally recorded ECGs and a standardized protocol were considered...
February 9, 2024: American Heart Journal
https://read.qxmd.com/read/38336159/characterizing-advanced-heart-failure-risk-and-hemodynamic-phenotypes-using-interpretable-machine-learning
#31
JOURNAL ARTICLE
Josephine Lamp, Yuxin Wu, Steven Lamp, Prince Afriyie, Nicholas Ashur, Kenneth Bilchick, Khadijah Breathett, Younghoon Kwon, Song Li, Nishaki Mehta, Edward Rojas Pena, Lu Feng, Sula Mazimba
BACKGROUND: Although previous risk models exist for advanced heart failure with reduced ejection fraction (HFrEF), few integrate invasive hemodynamics or support missing data. This study developed and validated a heart failure (HF) hemodynamic risk and phenotyping score for HFrEF, using Machine Learning (ML). METHODS: Prior to modeling, patients in training and validation HF cohorts were assigned to one of five risk categories based on the composite endpoint of death, left ventricular assist device (LVAD) implantation or transplantation (DeLvTx), and rehospitalization in 6 months of follow-up using unsupervised clustering...
February 7, 2024: American Heart Journal
https://read.qxmd.com/read/38325523/plasma-proteomics-for-prediction-of-subclinical-coronary-artery-calcifications-in-primary-prevention
#32
JOURNAL ARTICLE
Patrick Royer, Elias Björnson, Martin Adiels, María Bueno Álvez, Linn Fagerberg, Fredrik Bäckhed, Mathias Uhlén, Anders Gummesson, Göran Bergström
BACKGROUND AND AIMS: Recent developments in high-throughput proteomic technologies enable the discovery of novel biomarkers of coronary atherosclerosis. The aims of this study were to test if plasma protein subsets could detect coronary artery calcifications (CAC) in asymptomatic individuals and if they add predictive value beyond traditional risk factors. METHODS: Using proximity extension assays, 1342 plasma proteins were measured in 1827 individuals from the Impaired Glucose Tolerance and Microbiota (IGTM) study and 883 individuals from the Swedish Cardiopulmonary BioImage Study (SCAPIS) aged 50-64 years without history of ischaemic heart disease and with CAC assessed by computed tomography...
February 5, 2024: American Heart Journal
https://read.qxmd.com/read/38309610/transcatheter-aortic-valve-implantation-and-fractional-flow-reserve-guided-percutaneous-coronary-intervention-versus-conventional-surgical-aortic-valve-replacement-and-coronary-bypass-grafting-for-treatment-of-patients-with-aortic-valve-stenosis-and-multivessel
#33
JOURNAL ARTICLE
Elvin Kedhi, Andi Rroku, Rik S Hermanides, Jan Henk Dambrink, Sandeep Singh, Jurriën Ten Berg, Dirk-Jan van Winkel, Martin Hudec, Giovanni Amoroso, Ignacio J Amat-Santos, Martin Andreas, Rui Campante Teles, Guillaume Bonnet, Eric Van Belle, Lenard Conradi, Leen van Garsse, Wojtek Wojakowski, Vasileious Voudris, Jerzy Sacha, Pavel Cervinka, Erik Lipsic, Samer Somi, Luis Nombela-Franco, Sonja Postma, Kerstin Piayda, Giuseppe De Luca, Krzysztof Malinofski, Thomas Modine
BACKGROUND: Patients with severe aortic stenosis (AS) frequently present with concomitant obstructive coronary artery disease (CAD). In those, current guidelines recommend combined coronary artery bypass grafting (CABG) and surgical aortic valve replacement (SAVR) as the preferred treatment option, although this surgical approach is associated with a high rate of clinical events. Combined transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) with or without FFR have evolved as a valid alternative for cardiac surgery in patients with AS and multivessel or advanced CAD...
February 1, 2024: American Heart Journal
https://read.qxmd.com/read/38307365/regional-differences-in-outcomes-with-ablation-versus-drug-therapy-for-atrial-fibrillation-results-from-the-cabana-trial
#34
JOURNAL ARTICLE
Riccardo Cappato, Daniel B Mark, Adam P Silverstein, Peter A Noseworthy, Gianluca Bonitta, Jeanne E Poole, Jonathan P Piccini, Tristram D Bahnson, Melanie R Daniels, Hussein R Al-Khalidi, Kerry L Lee, Douglas L Packer
BACKGROUND: The finding of unexpected variations in treatment benefits by geographic region in international clinical trials raises complex questions about the interpretation and generalizability of trial findings. We observed such geographical variations in outcome and in the effectiveness of atrial fibrillation (AF) ablation versus drug therapy in the Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) trial. This paper describes these differences and investigates potential causes...
January 31, 2024: American Heart Journal
https://read.qxmd.com/read/38307364/variability-in-guideline-directed-medical-therapy-across-sites-and-operators-and-long-term-mortality-and-amputation-outcomes-risk-in-patients-undergoing-peripheral-vascular-interventions
#35
JOURNAL ARTICLE
Kim G Smolderen, Gaëlle Romain, Jacob Cleman, Lindsey Scierka, Carlos Mena-Hurtado
BACKGROUND: The use of guideline-directed medical therapy (GDMT) in patients undergoing peripheral vascular interventions (PVIs) decreases the risk of death and amputation and may decrease hospital readmissions. The variability of GDMT prescription across sites and operators and the proportionality of risk is not well understood. We aimed to study the association between variability of GDMT prescription at the site and operator level and outcomes (including 90-day readmissions and 24-month all-cause mortality and major amputation)...
January 31, 2024: American Heart Journal
https://read.qxmd.com/read/38278503/intracoronary-electrocardiogram-detects-coronary-microvascular-dysfunction-and-ischemia-in-patients-with-no-obstructive-coronary-arteries-disease
#36
JOURNAL ARTICLE
Erdem Cevik, Ahmet Tas, Zeynep G Demirtakan, Peter Damman, Yaren Alan, Christopher J Broyd, Alp Ozcan, Duygu H Simsek, Mehmet R Sonsoz, Niels van Royen, Divaka Perera, Justin E Davies, Sabahattin Umman, Murat Sezer
BACKGROUND: Coronary Microvascular Dysfunction (CMD) is the leading cause of ischemia with No Obstructive Coronary Arteries Disease (INOCA) disease. Diagnosis of CMD relies on surrogate physiological indices without objective proof of ischemia. OBJECTIVES: Intracoronary electrocardiogram (icECG) derived hyperemic indices may accurately and objectively detect CMD and reversible ischemia in related territory. METHODS: INOCA patients with proven ischemia by myocardial perfusion scan (MPS) and completely normal coronary arteries underwent simultaneous intracoronary electrophysiological (icECG) and physiological (Intracoronary Doppler) assessment in all three coronary arteries during rest and under adenosine induced hyperemia...
January 24, 2024: American Heart Journal
https://read.qxmd.com/read/38266665/rationale-and-design-of-the-node-303-study-evaluating-the-safety-of-symptom-prompted-self-administered-etripamil-for-paroxysmal-supraventricular-tachycardia-episodes-in-real-world-settings
#37
JOURNAL ARTICLE
James E Ip, Hanh Bui, A John Camm, Benoit Coutu, Peter A Noseworthy, Maria Leonor Parody, Samuel F Sears, Narendra Singh, Juan Agudelo Uribe, John Vyselaar, Sarah Omodele, Silvia Shardonofsky, David B Bharucha, Bruce Stambler
Paroxysmal supraventricular tachycardia (PSVT) is a common episodic arrhythmia characterized by unpredictable onset and burdensome symptoms including palpitations, dizziness, chest pain, distress, and shortness of breath. Treatment of acute episodes of PSVT in the clinical setting consists of intravenous adenosine, beta-blockers, and calcium channel blockers (CCBs). Etripamil is an intranasally self-administered L-type CCB in development for acute treatment of AV-nodal dependent PSVT in a non-medical supervised setting...
January 22, 2024: American Heart Journal
https://read.qxmd.com/read/38253305/radial-artery-versus-right-internal-mammary-artery-as-a-second-conduit-during-coronary-artery-bypass-grafting
#38
JOURNAL ARTICLE
Eishan Ashwat, James A Brown, Sarah Yousef, Danial Ahmad, Yisi Wang, Floyd W Thoma, Derek Serna-Gallegos, Pyongsoo Yoon, David West, Danny Chu, Johannes Bonatti, David Kaczorowski, Ibrahim Sultan
OBJECTIVE: To compare the clinical outcomes of radial artery (RA) grafts during CABG to those of right internal mammary artery (RIMA) grafts. METHODS: This was a retrospective, single-institution cohort study of isolated CABG with multiple grafts between 2010-2022. To balance graft cohorts, propensity score matching (PSM) was performed using a 1:1 match ratio. Long-term postoperative survival was compared among RA and RIMA groups. Similarly, major adverse cardiac and cerebrovascular events (MACCE) were compared among both cohorts, with MACCE comprising death, myocardial infarction (MI), coronary revascularization, and stroke...
January 20, 2024: American Heart Journal
https://read.qxmd.com/read/38253304/long-term-follow-up-of-balloon-expandable-valves-according-to-the-implantation-strategy-insight-from-the-directavi-trial
#39
JOURNAL ARTICLE
Nidal Jammoul, Valentin Dupasquier, Mariama Akodad, Pierre-Alain Meunier, Lionel Moulis, Sonia Soltani, Jean-Christophe Macia, Pierre Robert, Laurent Schmutz, Matthieu Steinecker, Christophe Piot, Frederic Targosz, Henri Benkemoun, Benoît Lattuca, François Roubille, Guillaume Cayla, Florence Leclercq
BACKGROUND: Safety and feasibility of transcatheter aortic valve replacement (TAVR) without balloon aortic valvuloplasty (BAV) using the SAPIEN 3 balloon-expandable device has been previously demonstrated. The impact on long-term valve hemodynamic performances and outcomes remains however unknown. We evaluate long-term clinical and hemodynamic results according to the implant strategy (direct TAVR versus BAV pre TAVR) in patients included in the DIRECTAVI randomized trial (NCT02729519)...
January 20, 2024: American Heart Journal
https://read.qxmd.com/read/38242417/drug-development-for-major-chronic-health-conditions-aligning-with-growing-public-health-needs-proceedings-from-a-multi-stakeholder-think-tank
#40
JOURNAL ARTICLE
Konstantin A Krychtiuk, Tomas Lg Andersson, Ulrike Bodesheim, Javed Butler, Lesley H Curtis, Mitchell Elkind, Adrian F Hernandez, Christoph Hornik, Gary H Lyman, Pooja Khatri, Michael Mbagwu, Masahiro Murakami, Gwen Nichols, Lothar Roessig, Anne Quinn Young, Richard L Schilsky, Neha Pagidipati
The global pharmaceutical industry portfolio is skewed towards cancer and rare diseases due to more predictable development pathways and financial incentives. In contrast, drug development for major chronic health conditions that are responsible for a large part of mortality and disability worldwide is stalled. To examine the processes of novel drug development for common chronic health conditions, a multi-stakeholder Think Tank meeting, including thought leaders from academia, clinical practice, non-profit healthcare organizations, the pharmaceutical industry, the Food and Drug Administration (FDA), payors as well as investors, was convened in July 2022...
January 17, 2024: American Heart Journal
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