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American Heart Journal

Neha J Pagidipati, Daniel W Mudrick, Karen Chiswell, Amanda Brucker, Eric D Peterson, Pamela S Douglas
BACKGROUND: Patients with nonobstructive coronary artery disease (CAD) have worse outcomes compared with those without CAD; however, few studies have compared the intermediate- and long-term impact of CAD severity as a function of patient sex. METHODS: We evaluated 5-year and long-term all-cause mortality of women and men undergoing elective coronary angiography at a single center by degree of CAD: no CAD (1%-24% stenosis), nonobstructive CAD (25%-69% epicardial stenosis or 25%-49% left main stenosis), or obstructive CAD (epicardial stenosis ≥70% or left main stenosis ≥50%), both overall and after adjusting for baseline clinical risk factors using Cox proportional-hazards models...
October 2, 2018: American Heart Journal
Michael Dandel, Roland Hetzer
By reduction of ventricular wall-tension and improving the blood supply to vital organs, ventricular assist devices (VADs) can eliminate the major pathophysiological stimuli for cardiac remodeling and even induce reverse remodeling occasionally accompanied by clinically relevant reversal of cardiac structural and functional alterations allowing VAD explantation, even if the underlying cause for the heart failure (HF) was dilated cardiomyopathy. Accordingly, a tempting potential indication for VADs in the future might be their elective implantation as a therapeutic strategy to promote cardiac recovery in earlier stages of HF, when the reversibility of morphological and functional alterations is higher...
September 17, 2018: American Heart Journal
Leah L Zullig, Lisa Egbuonu-Davis, Anjali Trasy, Christiana Oshotse, Karen M Goldstein, Hayden B Bosworth
No abstract text is available yet for this article.
September 14, 2018: American Heart Journal
Fabian R Reimold, Matthew R Reynolds
No abstract text is available yet for this article.
September 12, 2018: American Heart Journal
Christopher P Cannon, Darren K McGuire, Richard Pratley, Sam Dagogo-Jack, James Mancuso, Susan Huyck, Bernard Charbonnel, Weichung J Shih, Silvina Gallo, Urszula Masiukiewicz, Gregory Golm, Francesco Cosentino, Brett Lauring, Steven G Terra
BACKGROUND: Ertugliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), approved in the United States and European Union to improve glycemic control in adults with type 2 diabetes mellitus (T2DM). The VERTIS cardiovascular (CV) outcomes trial (NCT01986881) has a primary objective to demonstrate non-inferiority of ertugliflozin versus placebo on major adverse CV events: time to the first event of CV death, nonfatal myocardial infarction, or nonfatal stroke. Secondary objectives are to demonstrate superiority of ertugliflozin versus placebo on time to: 1) the composite outcome of CV death or hospitalization for heart failure (HF); 2) CV death; and 3) the composite outcome of renal death, dialysis/transplant, or doubling of serum creatinine from baseline...
September 5, 2018: American Heart Journal
José A Nieto, Julio A Vicente, Luis M Prieto, David Jiménez, Behnood Bikdeli, Agustina Rivas, José Antonio Porras, Mª Del Valle Morales, Marijan Bosevski, Manuel Monreal
BACKGROUND: The contemporary natural history of patients with acute pulmonary embolism (PE) not receiving (or early discontinuing) anticoagulant therapy has not been consistently evaluated. OBJECTIVE: To assess the rate of the composite outcome of PE-related death, sudden death, or recurrent thromboembolism (VTE) within 30 days in all PE patients in whom anticoagulation was not administered or discontinued prematurely (<90 days of anticoagulation). METHODS: We used the RIETE database to assess the incidence rates (per 100 person-days) of the composite outcome within the subsequent 30 days...
September 5, 2018: American Heart Journal
Renato D Lopes, Weimar Kunz Sebba Barroso, Andrea Araujo Brandao, Eduardo Costa Duarte Barbosa, Marcus Vinicius Bolivar Malachias, Marco Mota Gomes, Celso Amodeo, Rui Manoel Dos Santos Povoa, Margaret Assad Cavalcante, Dalton Bertolim Précoma, Antônio Carlos Sobral Sousa, João Miguel Malta Dantas, Evandro José Cesarino, Paulo Cesar B Veiga Jardim
A systematic, nationwide assessment of care of patients with hypertension in Brazil is needed. The objective of the First National Registry of Patients with Hypertension in Brazil is to evaluate the clinical profile, treatment patterns, and outcomes of diagnosed hypertensive patients in the country.
August 30, 2018: American Heart Journal
Islam Y Elgendy, Hend Mansoor, Qian Li, Yi Guo, Eileen M Handberg, C Noel Bairey Merz, Carl J Pepine
The aim of this study was to determine the long-term prognostic value of the Duke Activity Status Index-estimated metabolic equivalents (METs) values among women with suspected ischemic heart disease. At a median of 9.6 years, the incidence of death was 23.4% in those with METs <4.8 versus 8.2% in METs >9.9, P < .01. In conclusion, use of the simple, patient-reported Duke Activity Status Index could help identify higher-risk women with suspected ischemic heart disease for targeted risk management...
August 30, 2018: American Heart Journal
Nicolas M Van Mieghem, Martin Unverdorben, Marco Valgimigli, Roxana Mehran, Eric Boersma, Usman Baber, Christian Hengstenberg, Minggao Shi, Cathy Chen, Shigeru Saito, Roland Veltkamp, Pascal Vranckx, George D Dangas
Transcatheter aortic valve implantation, also called transcatheter aortic valve replacement (TAVR), is the treatment of choice for patients with severe aortic stenosis and intermediate to high operative risk. A significant portion of TAVR patients have atrial fibrillation (AF) requiring chronic oral anticoagulation. In moderate- to high-risk AF patients, the direct factor Xa inhibitor edoxaban is noninferior to vitamin K antagonists (VKAs) for prevention of stroke or systemic embolism with less bleeding and cardiovascular deaths...
August 29, 2018: American Heart Journal
Leif Friberg
AIM: The aim of the study was to assess and compare the safety of antiarrhythmic drugs (AADs) in an unselected real-world population of patients with atrial fibrillation (AF). METHODS AND RESULTS: This is a study of all patients with diagnosed AF in the Swedish Patient register who filled a prescription for sotalol, amiodarone, dronedarone, flecainide or disopyramide during 2010 to 2015. The main end point consisted of arrhythmic death, successful resuscitation, new diagnosis of sustained ventricular tachycardia, ventricular fibrillation or implantation of ICD...
August 25, 2018: American Heart Journal
Juhwan Lee, Rine Nakanishi, Dong Li, Kashif Shaikh, Chandana Shekar, Kazuhiro Osawa, Negin Nezarat, Eranthi Jayawardena, Maja Blanco, Matthew Chen, Matthew Sieckert, Eric Nelson, Darius Billingsley, Sajad Hamal, Matthew J Budoff
Warfarin, a vitamin K antagonist, is associated with systemic vascular calcification. We evaluated whether rivaroxaban (a direct oral factor Xa inhibitor with no interaction with vitamin K) will slow the progression in coronary plaque volumes compared with warfarin in patients with nonvalvular atrial fibrillation using coronary computed tomography angiography.
August 24, 2018: American Heart Journal
Fernando Alfonso, Javier Cuesta, Marcos García-Guimaraes, Esther Gonzalez-Barthol, Paula Antuña, Teresa Bastante, Fernando Rivero
No abstract text is available yet for this article.
August 24, 2018: American Heart Journal
Do-Yoon Kang, Yiu Tung Anthony Wong, Duk-Woo Park, Seung-Jung Park
No abstract text is available yet for this article.
August 23, 2018: American Heart Journal
Anoop N Koshy, Jithin K Sajeev, Kazuaki Negishi, Michael C Wong, Christopher B Pham, Sumudu P Cooray, Yeganeh Khavar, Louise Roberts, Jennifer C Cooke, Andrew W Teh
Despite the appeal of smartphone-based electrocardiograms (ECGs) for arrhythmia screening, a paucity of data exists on the accuracy of primary care physicians' and cardiologists' interpretation of tracings compared with the device's automated diagnosis. Using 408 ECGs in 51 patients, we demonstrate a variable accuracy in clinician interpretation of smartphone-based ECGs, with only cardiologists demonstrating satisfactory agreement when referenced against a 12-lead ECG. Combining the device automated diagnostic algorithm with cardiologist interpretation of only uninterpretable traces yielded excellent results and provides an efficient, cost-effective workflow for the utilization of a smartphone-based ECG in clinical practice...
August 23, 2018: American Heart Journal
Laura Mauri, Ajay J Kirtane, Stephan Windecker, Robert W Yeh, Harold L Dauerman, Matthew J Price, Thomas Christen, Dominic J Allocco, Ian T Meredith, Dean J Kereiakes
BACKGROUND: While extended dual antiplatelet therapy (DAPT) with aspirin and a platelet (P2Y12 ) inhibitor after percutaneous coronary intervention (PCI) reduces the risk of stent thrombosis (ST) and myocardial infarction (MI), it also increases bleeding. Newer generation drug-eluting stents with bioabsorbable polymer coatings may reduce thrombotic events and allow abbreviated DAPT in selected patients. The EVOLVE Short DAPT study is designed to evaluate the safety of 3-month DAPT in high bleeding risk subjects treated with the SYNERGY bioabsorbable polymer everolimus-eluting stent...
August 17, 2018: American Heart Journal
Niels Ramsing Holm, Lene Nyhus Andreasen, Simon Walsh, Olli A Kajander, Nils Witt, Christian Eek, Paul Knaapen, Lukasz Koltowski, Juan Luis Gutiérrez-Chico, Francesco Burzotta, Janusz Kockman, John Ormiston, Irene Santos-Pardo, Peep Laanmets, Darren Mylotte, Morten Madsen, Jakob Hjort, Indulis Kumsars, Truls Råmunddal, Evald Høj Christiansen
No abstract text is available yet for this article.
August 16, 2018: American Heart Journal
Eloisa Colin-Ramirez, Justin A Ezekowitz
BACKGROUND: Patients with heart failure (HF) remain at high risk for future events despite medical and device therapy. Dietary sodium reduction is often recommended based on limited evidence. However, it is not known whether dietary sodium reduction reduces the morbidity or mortality associated with HF. METHODS: The SODIUM study is a pragmatic, randomized, open-label trial assessing the efficacy of dietary sodium reduction to <1500 mg daily counseling compared to usual care for patients with chronic HF...
August 16, 2018: American Heart Journal
Daniëlle C Eindhoven, Hoi W Wu, Stijn W F Kremer, Judith A van Erkelens, Suzanne C Cannegieter, Martin J Schalij, C Jan Willem Borleffs
No abstract text is available yet for this article.
August 16, 2018: American Heart Journal
Christine J Chung, Ajay J Kirtane, Yiran Zhang, Bernhard Witzenbichler, Giora Weisz, Thomas D Stuckey, Bruce R Brodie, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Roxana Mehran, Gregg W Stone
BACKGROUND: Whether high on-aspirin platelet reactivity (HAPR) confers an increased risk of adverse outcomes after percutaneous coronary intervention (PCI) remains unclear. We sought to examine the specific relationship between HAPR and clinical outcomes in ADAPT-DES. METHODS: A total of 8,526 "all-comer" patients in the ADAPT-DES registry who underwent placement of drug-eluting stents (DES) and were treated with aspirin and clopidogrel were assessed to measure platelet reactivity...
August 15, 2018: American Heart Journal
William B White, Fatima Jalil, Dorothy B Wakefield, Richard F Kaplan, Richard W Bohannon, Charles B Hall, Nicola Moscufo, Douglas Fellows, Charles R G Guttmann, Leslie Wolfson
BACKGROUND: Subcortical small vessel disease, represented as white matter hyperintensity (WMH) on magnetic resonance images (MRI) is associated with functional decline in older people with hypertension. We evaluated the relationships of clinic and out-of-office blood pressures (BP) with WMH and functional status in older persons. METHODS: Using cross-sectional data from 199 older study participants enrolled in the INFINITY trial, we analyzed the clinic, 24-hour ambulatory, and home BPs and their relationships with WMH burden and mobility and cognitive outcomes...
August 11, 2018: American Heart Journal
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