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American Heart Journal

Peter F Aziz, Stuart Berger, Peter Kowey, Mitchell Krucoff, Martha Lopez-Anderson, Eric Michelson, Silvana Molossi, Valarie Morrow, Ignacio Rodriguez, Tess Elizabeth Saarel, Colette Strnadova, Victoria Vetter, Theressa J Wright, Salim F Idriss
Sudden cardiac death in the young (SCDY) spans gender, race, ethnicity, and socioeconomic class. The loss of any pediatric patient is a matter of national and international public health concern, and focused efforts should be aimed at preventing these burdensome tragedies. Prepared by members of the Cardiac Safety Research Consortium, this White Paper summarizes and reports the dialogue at the second Think Tank related to the issues and the proposed solutions for the development of a national resource for screening and prevention of SCDY...
May 23, 2018: American Heart Journal
Orly Vardeny, Jacob A Udell, Jacob Joseph, Michael E Farkouh, Adrian F Hernandez, Alison J McGeer, H Keipp Talbot, Deepak L Bhatt, Christopher P Cannon, Shaun G Goodman, Inder Anand, David L DeMets, Jon Temte, Janet Wittes, Kristin Nichol, Clyde W Yancy, J Michael Gaziano, Lawton S Cooper, KyungMann Kim, Scott D Solomon
BACKGROUND: Influenza leads to significant cardiopulmonary morbidity and mortality-particularly in patients with cardiovascular disease-that may be prevented with a standard influenza vaccine. However, patients with cardiovascular conditions have a reduced immune response to influenza vaccine, potentially resulting in reduced effectiveness for preventing clinical events. High-dose vaccine augments immune response in cardiac patients, suggesting that a high-dose influenza vaccination strategy may further reduce morbidity and mortality...
May 23, 2018: American Heart Journal
Johan Holmén, Johan Herlitz, Christer Axelsson
No abstract text is available yet for this article.
May 22, 2018: American Heart Journal
Miguel Cainzos-Achirica, Cristina Rebordosa, Emili Vela, Montse Cleries, Kunihiro Matsushita, Estel Plana, Elena Rivero-Ferrer, Cristina Enjuanes, Santiago Jimenez-Marrero, Luis Alberto Garcia-Rodriguez, Josep Comin-Colet, Susana Perez-Gutthann
Epidemiological studies on heart failure (HF) using large health care databases are becoming increasingly frequent, as they represent an invaluable opportunity to characterize the importance and risk factors of HF from a population perspective. Nevertheless, because of its complex diagnosis and natural history, the heterogeneous use of the relevant terminology in routine clinical practice, and the limitations of some disease coding systems, HF can be a challenging condition to assess using large health care databases as the main source of information...
May 21, 2018: American Heart Journal
Adriana Luk, John D Groarke, Akshay S Desai, Syed Saad Mahmood, Deepa M Gopal, Emer Joyce, Sachin P Shah, Joann Lindenfeld, Lynne Stevenson, Neal K Lakdawala
BACKGROUND: Relief of congestion is the primary goal of initial therapy for acute decompensated heart failure (ADHF). Early measurement of urine sodium concentration (UNa) may be useful to identify patients with diminished response to diuretics. The aim of this study was to determine if the first spot UNa after diuretic initiation could select patients likely to require more intensive therapy during hospitalization. METHODS: At the time of admission, 103 patients with ADHF were identified prospectively, and UNa was measured after the first dose of intravenous diuretic...
May 19, 2018: American Heart Journal
Sean van Diepen, Dat T Tran, Justin A Ezekowitz, David A Zygun, Jason N Katz, Renato D Lopes, L Kristin Newby, Finlay A McAlister, Padma Kaul
BACKGROUND: There is substantial variability among hospitals in critical care unit (CCU) utilization for patients admitted with non-ST-Segment Elevation Acute Coronary Syndromes (NSTE ACS). We estimated the potential cost saving if all hospitals adopted low CCU utilization practices for patients with NSTE ACS. METHODS: National hospital claims data were used to identify all patients with a primary diagnosis of NSTE ACS initially admitted to an acute care hospital between 2007 and 2013...
May 19, 2018: American Heart Journal
Kenichi Shibata, Masanori Yamamoto, Seiji Kano, Yutaka Koyama, Tetsuro Shimura, Ai Kagase, Sumio Yamada, Toshihiro Kobayashi, Norio Tada, Toru Naganuma, Motoharu Araki, Futoshi Yamanaka, Shinichi Shirai, Kazuki Mizutani, Minoru Tabata, Hiroshi Ueno, Kensuke Takagi, Akihiro Higashimori, Yusuke Watanabe, Toshiaki Otsuka, Kentaro Hayashida
BACKGROUND: Nutritional condition is one marker of patients' frailty. The Geriatric Nutritional Risk Index (GNRI) is a well-known marker of nutritional status. This study sought to assess the clinical outcomes of GNRI after transcatheter aortic valve replacement (TAVR). METHODS: We evaluated the GNRI value of 1,613 patients who underwent TAVR using data from a Japanese multicenter registry. According to baseline GNRI, patients were classified into 3 groups: GNRI ≥92 (n = 1,085; 67...
May 15, 2018: American Heart Journal
Maya L Chan, John A Spertus, Yuanyuan Tang, Monique Anderson Starks, Paul S Chan
BACKGROUND: Despite the high incidence of in-hospital cardiac arrest (IHCA) in US hospitals, the prognosis and end-of-life decision-making patterns of a patient with a recurrent IHCA are unknown. METHODS: Within Get-With-The-Guidelines-Resuscitation, we identified 192,250 patients from 711 hospitals with an IHCA from 2000 to 2015. Patients were categorized as having no recurrent IHCA (only 1 event), recurrent IHCA (≥2 IHCAs), and recurrent out-of-hospital cardiac arrest (OHCA), defined as an IHCA after an OHCA...
May 9, 2018: American Heart Journal
Jacob C Jentzer
No abstract text is available yet for this article.
May 9, 2018: American Heart Journal
Benjamin M Scirica, Sameer Bansilal, Farideh Davoudi, Paul W Armstrong, Robert M Clare, Phillip J Schulte, Karen S Pieper, Richard C Becker, Stefan K James, Robert F Storey, Philippe Gabriel Steg, Claes Held, Anders Himmelmann, Kenneth W Mahaffey, Lars Wallentin, Christopher P Cannon
BACKGROUND: Although bradyarrhythmias have been observed with ticagrelor and its use with advanced atrioventricular block is not recommended, questions arise regarding its use in patients with mild conduction abnormalities. The objectives were to compare rates of clinically relevant arrhythmias in relation to any mild baseline conduction abnormality in patients with acute coronary syndrome randomized to ticagrelor versus clopidogrel. METHODS: We included all subjects in the electrocardiographic (ECG) substudy of the Platelet Inhibition and Patient Outcomes trial, excluding those with missing baseline ECG or with a pacemaker at baseline (N = 15,460)...
May 7, 2018: American Heart Journal
Lars Jakobsen, Evald H Christiansen, Michael Maeng, Steen D Kristensen, Hans E Bøtker, Christian J Terkelsen, Morten Madsen, Bent Raungaard, Svend E Jensen, Martin K Christensen, Henrik Steen Hansen, Lisette O Jensen
BACKGROUND: The Combo stent (OrbusNeich, Hoevelaken, the Netherlands) combining an abluminal, bioabsorbable polymer eluting sirolimus with a luminal CD34+ antibody to capture endothelial progenitor cells has been developed to further improve safety and efficacy of coronary interventions. We have designed a large-scale registry-based randomized clinical trial to compare the Combo stent to the Orsiro stent (Biotronik, Bülach, Switzerland) in patients undergoing percutaneous coronary intervention...
May 5, 2018: American Heart Journal
Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Yh Lip
BACKGROUND: Most data on the clinical epidemiology of atrial fibrillation (AF) are reported from Western populations, and data for Asians are limited. We aimed to investigate the 10-year trends of the prevalence and incidence of non-valvular AF and provide prevalence projections till 2060 in Korea. We also investigated the annual risks of adverse outcomes among patients with AF. METHODS: Using the Korean National Health Insurance Service database involving the entire Korean population, a total of 679,416 adults with newly diagnosed AF were identified from 2006 to 2015...
May 1, 2018: American Heart Journal
Sudha R Raman, Lesley H Curtis, Robert Temple, Tomas Andersson, Justin Ezekowitz, Ian Ford, Stefan James, Keith Marsolo, Parsa Mirhaji, Mitra Rocca, Russell L Rothman, Barathi Sethuraman, Norman Stockbridge, Sharon Terry, Scott M Wasserman, Eric D Peterson, Adrian F Hernandez
Electronic health records (EHRs) can be a major tool in the quest to decrease costs and timelines of clinical trial research, generate better evidence for clinical decision making, and advance health care. Over the past decade, EHRs have increasingly offered opportunities to speed up, streamline, and enhance clinical research. EHRs offer a wide range of possible uses in clinical trials, including assisting with prestudy feasibility assessment, patient recruitment, and data capture in care delivery. To fully appreciate these opportunities, health care stakeholders must come together to face critical challenges in leveraging EHR data, including data quality/completeness, information security, stakeholder engagement, and increasing the scale of research infrastructure and related governance...
April 30, 2018: American Heart Journal
Amy M O'Connor, Andrew H Smith, Kim Crum, Todd L Edwards, Prince J Kannankeril
BACKGROUND: Atrial tachycardia (AT) after infant congenital heart disease (CHD) surgery is associated with increased mortality. Polymorphisms in PITX2 (rs2200733) and IL6 (rs1800795) are associated with postoperative atrial fibrillation in adults but have not been studied in CHD. The objective was to test the hypothesis that clinical factors and variants in PITX2 and IL6 are associated with postoperative AT in infants with CHD. METHODS: Infants (<1 year of age) undergoing CHD surgery between September 2007 and May 2016 were included...
April 30, 2018: American Heart Journal
Majd A El-Harasis, Heidi M Connolly, William R Miranda, Muhammad Y Qureshi, Nandini Sharma, Mohamad Al-Otaibi, Christopher V DeSimone, Alexander Egbe
BACKGROUND: The optimal interval between serial cardiac magnetic resonance imaging (CMRI) scans for monitoring right ventricular (RV) enlargement in the setting of severe pulmonic valve regurgitation (PR) is unknown. The purposes of this study were to (1) determine the annual change in RV volume on serial CMRI scans and (2) identify the risk factors for rapid progression of RV enlargement. METHODS: A retrospective study of adults with postintervention native valve PR and ≥2 CMRI scans at Mayo Clinic Rochester from 2000 to 2015 was conducted...
April 26, 2018: American Heart Journal
Tanya M Spruill, Harmony R Reynolds, Victoria Vaughan Dickson, Amanda J Shallcross, Pallavi D Visvanathan, Chorong Park, Jolaade Kalinowski, Hua Zhong, Jeffrey S Berger, Judith S Hochman, Glenn I Fishman, Gbenga Ogedegbe
BACKGROUND: Elevated stress is associated with adverse cardiovascular disease outcomes and accounts in part for the poorer recovery experienced by women compared with men after myocardial infarction (MI). Psychosocial interventions improve outcomes overall but are less effective for women than for men with MI, suggesting the need for different approaches. Mindfulness-based cognitive therapy (MBCT) is an evidence-based intervention that targets key psychosocial vulnerabilities in women including rumination (i...
April 21, 2018: American Heart Journal
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
Krishna K Patel, Suzanne V Arnold, Paul S Chan, Yuanyuan Tang, Philip G Jones, Jianping Guo, Donna M Buchanan, Mohammed Qintar, Carole Decker, David A Morrow, John A Spertus
BACKGROUND: Although the Seattle Angina Questionnaire (SAQ) has been widely used to assess disease-specific health status in patients with ischemic heart disease, it was originally developed in a predominantly male population and its validity in women has been questioned. METHODS: Using data from 8892 men and 4013 women across 2 multicenter trials and 5 registries, we assessed the construct validity, test-retest reliability, responsiveness to clinical change, and predictive validity of the SAQ Summary Score (SS) and its 5 subdomains (Physical Limitation (PL), Anginal Stability (AS), Angina Frequency (AF), Treatment Satisfaction (TS), and Quality of Life (QoL)) separately in men and women...
April 21, 2018: American Heart Journal
Kanjana S Perera, Mukul Sharma, Stuart J Connolly, Jia Wang, Michael R Gold, Stefan H Hohnloser, Chu Pak Lau, Isabelle C Van Gelder, Carlos Morillo, Alessandro Capucci, Carsten W Israel, Gluca Botto, Jeffery S Healey
BACKGROUND: The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) demonstrated that subclinical atrial fibrillation (SCAF) was associated with a 2.5-fold increased risk of stroke. However, the absolute stroke rate was only 1.7% per year and fewer than 20% patients with stroke had SCAF in the preceding 30 days. This raises the possibility that SCAF is merely a risk marker for stroke rather than the cause...
April 18, 2018: American Heart Journal
Jafna L Cox, Ratika Parkash, Syed Sr Abidi, Lehana Thabane, Feng Xie, James MacKillop, Samina R Abidi, Antonio Ciaccia, Shurjeel H Choudhri, A Abusharekh, Joanna Nemis-White
The Integrated Management Program Advancing Community Treatment of Atrial Fibrillation (IMPACT-AF) is an investigator designed, prospective, randomized, un-blinded, cluster design clinical trial, conducted in the primary care setting of Nova Scotia, Canada. Its aim is to evaluate whether an electronic Clinical Decision Support System (CDSS) designed to assist both practitioners and patients with evidence-based management strategies for Atrial Fibrillation (AF) can improve process of care and outcomes in a cost-efficient manner as compared to usual AF care...
April 7, 2018: American Heart Journal
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