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American Heart Journal

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https://www.readbyqxmd.com/read/28938971/response-to-the-letter-to-the-editor
#1
LETTER
Kelsey M Flint
No abstract text is available yet for this article.
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938970/building-the-case-for-aerobic-exercise-in-ambulatory-patients-with-heart-failure-and-a-reduced-ejection-fraction
#2
LETTER
Lukasz P Cerbin, Andrew P Ambrosy, Robert J Mentz
No abstract text is available yet for this article.
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938969/cardiac-rehabilitation-in-heart-failure-with-reduced-ejection-fraction-a-should-take-it-and-not-leave-it-intervention
#3
LETTER
Rod Taylor, Hayes Dalal, Russell Davies, Patrick Doherty, Kate Jolly, Chim Lang, Jenny Wingham
No abstract text is available yet for this article.
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938968/the-lipid-rich-plaque-study-of-vulnerable-plaques-and-vulnerable-patients-study-design-and-rationale
#4
REVIEW
Ron Waksman, Rebecca Torguson, Mia-Ashley Spad, Hector Garcia-Garcia, James Ware, Rui Wang, Sean Madden, Priti Shah, James Muller
BACKGROUND: It has been hypothesized that the outcome post-PCI could be improved by the detection and subsequent treatment of vulnerable patients and lipid-rich vulnerable coronary plaques (LRP). A near-infrared spectroscopy (NIRS) catheter capable of detecting LRP is being evaluated in The Lipid-Rich Plaque Study. STUDY DESIGN: The LRP Study is an international, multicenter, prospective cohort study conducted in patients with suspected coronary artery disease (CAD) who underwent cardiac catheterization with possible ad hoc PCI for an index event...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938967/increasing-propensity-to-pursue-operative-closure-of-atrial-septal-defects-following-changes-in-the-instructions-for-use-of-the-amplatzer-septal-occluder-device-an-observational-study-using-data-from-the-pediatric-health-information-systems-database
#5
MULTICENTER STUDY
Michael L O'Byrne, Russell T Shinohara, Elena K Grant, Joshua P Kanter, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Andrew C Glatz
Concern for device erosion following transcatheter treatment of atrial septal defects (TC-ASD) led in 2012 to a United States Food and Drug Administration panel review and changes in the instructions for use of the Amplatzer Septal Occluder (ASO) device. No studies have assessed the effect of these changes on real-world practice. To this end a multicenter observational study was performed to evaluate trends in the treatment of ASD. METHODS: A retrospective observational study was performed using data from the Pediatric Health Information Systems database of all patients with isolated ASD undergoing either TC-ASD or operative ASD closure (O-ASD) from January 1, 2007, to September 30, 2015, hypothesizing that the propensity to pursue O-ASD increased beginning in 2013...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938966/high-screen-failure-rate-in-patients-with-resistant-hypertension-findings-from-symplicity-htn-3
#6
RANDOMIZED CONTROLLED TRIAL
Ron Waksman, George L Bakris, Arie Steinvil, Hector Garcia-Garcia, Angela L Brown, William DiFilippo, Thomas Scott, Jasvindar Singh, Vanessa DeBruin, Denise Jones, Dan Jolivette, Deepak L Bhatt
BACKGROUND: The SYMPLICITY HTN-3 trial, which randomized subjects to renal denervation (RDN) or sham control, was designed to evaluate the efficacy and safety of RDN for the treatment of resistant hypertension. Outcomes were previously reported. This retrospective analysis evaluated reasons for screen failure (SF) for randomization in the trial. METHODS: SYMPLICITY HTN-3 enrolled subjects with office systolic blood pressure (SBP) ≥160 mmHg on stable and maximal doses of ≥3 antihypertensive medication classes...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938965/impact-of-atrial-fibrillation-on-outcomes-of-patients-treated-by-transcatheter-aortic-valve-implantation-a-systematic-review-and-meta-analysis
#7
REVIEW
Marco Mojoli, Bernard J Gersh, Alberto Barioli, Giulia Masiero, Paola Tellaroli, Gianpiero D'Amico, Giuseppe Tarantini
BACKGROUND: Conflicting data have been reported related to the impact of atrial fibrillation (AF) on the outcomes after transcatheter aortic valve implantation (TAVI). We aimed to assess the prognosis of TAVI-treated patients according to the presence of pre-existing or new-onset AF. METHODS: Studies published between April 2002 and November 2016 and reporting outcomes of pre-existing AF, new-onset AF, or sinus rhythm in patients undergoing TAVI were identified with an electronic search...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938964/predictors-of-permanent-pacemaker-implantation-after-transfemoral-aortic-valve-implantation-with-the-lotus-valve
#8
Mirjam Keßler, Birgid Gonska, Julia Seeger, Wolfgang Rottbauer, Jochen Wöhrle
BACKGROUND: Permanent pacemaker implantation (PPMI) after transcatheter aortic valve implantation is of high clinical relevance, but PPMI rates differ widely between valve types. Although the Lotus valve can be repositioned, reported rates for PPMI are high. The predictors of PPMI after Lotus valve implantation have not been defined yet. METHODS: We analyzed the impact of preexisting conduction disturbances, depth of implantation, oversizing, and amount of calcification on PPMI in 216 patients with severe symptomatic aortic stenosis underdoing Lotus valve implantation...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938963/study-design-and-rationale-for-elpis-a-phase-i-iib-randomized-pilot-study-of-allogeneic-human-mesenchymal-stem-cell-injection-in-patients-with-hypoplastic-left-heart-syndrome
#9
RANDOMIZED CONTROLLED TRIAL
Sunjay Kaushal, Brody Wehman, Nicholas Pietris, Casey Naughton, Soren M Bentzen, Grace Bigham, Rachana Mishra, Sudhish Sharma, Luca Vricella, Allen D Everett, Kristopher B Deatrick, Sihong Huang, Helina Mehta, William A Ravekes, Naru Hibino, Darcy L Difede, Aisha Khan, Joshua M Hare
Despite advances in surgical technique and postoperative care, long-term survival of children born with hypoplastic left heart syndrome (HLHS) remains limited, with cardiac transplantation as the only alternative for patients with failing single ventricle circulations. Maintenance of systemic right ventricular function is crucial for long-term survival, and interventions that improve ventricular function and avoid or defer transplantation in patients with HLHS are urgently needed. We hypothesize that the young myocardium of the HLHS patient is responsive to the biological cues delivered by bone marrow-derived mesenchymal stem cells (MSCs) to improve and preserve right ventricle function...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938962/regional-differences-in-presentation-and-antithrombotic-treatment-of-patients-with-atrial-fibrillation-baseline-characteristics-from-a-clustered-randomized-trial-to-improve-treatment-with-anticoagulants-in-patients-with-atrial-fibrillation-impact-af
#10
RANDOMIZED CONTROLLED TRIAL
Dragos Vinereanu, Hussein R Al-Khalidi, Meena P Rao, Wensheng He, Renato D Lopes, Cecilia M Bahit, Andrea O Ciobanu, Kathleen A Fox, Sean D Pokorney, Ying Xian, Jie Jiang, Deepak Y Kamath, Otavio Berwanger, Carlos Tajer, Yong Huo, Denis Xavier, Christopher B Granger
Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide. However, there are few contemporary comparative data on AF from middle-income countries. METHODS: Baseline characteristics of the IMPACT-AF trial were analyzed to assess regional differences in presentation and antithrombotic treatment of AF from 5 middle-income countries (Argentina, Brazil, China, India, and Romania) and factors associated with antithrombotic treatment prescription. RESULTS: IMPACT-AF enrolled 2281 patients (69 ± 11 years, 47% women) at 48 sites...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938961/rationale-and-design-of-the-icon-reloaded-study-international-collaborative-of-n-terminal-pro-b-type-natriuretic-peptide-re-evaluation-of-acute-diagnostic-cut-offs-in-the-emergency-department
#11
RANDOMIZED CONTROLLED TRIAL
Hanna Kim Gaggin, Annabel Angela Chen-Tournoux, Robert H Christenson, Gheorghe Doros, Judd Eric Hollander, Phillip David Levy, John Tobias Nagurney, Richard Michael Nowak, Peter S Pang, Darshita Patel, Willam Frank Peacock, Elizabeth Lea Walters, James Louis Januzzi
OBJECTIVES: The objectives were to reassess use of amino-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations for diagnosis and prognosis of acute heart failure (HF) in patients with acute dyspnea. BACKGROUND: NT-proBNP facilitates diagnosis, prognosis, and treatment in patients with suspected or proven acute HF. As demographics of such patients are changing, previous diagnostic NT-proBNP thresholds may need updating. Additionally, value of in-hospital NT-proBNP prognostic monitoring for HF is less understood...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938960/galectin-3-and-incidence-of-atrial-fibrillation-the-atherosclerosis-risk-in-communities-aric-study
#12
MULTICENTER STUDY
Oluwaseun E Fashanu, Faye L Norby, David Aguilar, Christie M Ballantyne, Ron C Hoogeveen, Lin Y Chen, Elsayed Z Soliman, Alvaro Alonso, Aaron R Folsom
BACKGROUND: Galectin-3, a β-galactoside binding lectin involved in important regulatory roles in adhesion, inflammation, immunity, and fibrosis, may be relevant to atrial fibrillation (AF) etiology. METHODS: We included 8,436 participants free of AF at baseline (1996-1998) and with measures of plasma galectin-3 from the Atherosclerosis Risk in Communities study. We ascertained incident AF through 2013 from study visit electrocardiograms, hospitalizations, and death certificates...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938959/rheumatoid-arthritis-complicates-noninvasive-whole-blood-gene-expression-testing-for-coronary-artery-disease
#13
Ryan Jessee, Erica Peart, Phil Beineke, Steven Rosenberg, James A Wingrove, William E Kraus, Kim M Huffman
BACKGROUND: Our objective was to evaluate an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive coronary artery disease (CAD) in patients with rheumatoid arthritis (RA). METHODS: We evaluated 20 pairs of nondiabetic coronary patients with and without RA, selected by matching on age, sex, race, body mass index, tobacco use, and number of diseased coronary vessels. Peripheral blood gene expression levels of 23 CAD-associated genes were measured, and a previously validated CAD risk score including age, sex, and gene expression levels (Corus CAD) was computed...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938958/pulmonary-hemodynamics-in-heart-failure-patients-with-reduced-or-preserved-ejection-fraction-and-pulmonary-hypertension-similarities-and-disparities
#14
Yochai Adir, Marco Guazzi, Amir Offer, Pier Luigi Temporelli, Antonia Cannito, Stefano Ghio
OBJECTIVE: The current understanding of pulmonary hypertension (PH) due to left ventricular diseases does not distinguish heart failure (HF) with reduced ejection fraction (HFrEF) from HF and preserved ejection fraction (HFpEF), in terms of pulmonary hemodynamics. The value of pulmonary vascular compliance (PCa) and diastolic pulmonary gradient (DPG) as predictors of survival in either HF syndrome is controversial. The aims of our study were to compare the pulmonary hemodynamics in the two HF phenotypes, given similar values of pulmonary artery wedge pressure (PAWP), and to evaluate the impact of PCa and DPG on survival...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938957/overview-of-the-2017-us-food-and-drug-administration-circulatory-system-devices-panel-meeting-on-the-sentinel-cerebral-protection-system
#15
Toby Rogers, M Chadi Alraies, Rebecca Torguson, Ron Waksman
No abstract text is available yet for this article.
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938956/effects-of-ticagrelor-versus-clopidogrel-on-platelet-function-in-fibrinolytic-treated-stemi-patients-undergoing-early-pci
#16
RANDOMIZED CONTROLLED TRIAL
Payam Dehghani, Andrea Lavoie, Shahar Lavi, Jennifer J Crawford, Sebastian Harenberg, Rodney H Zimmermann, Jeff Booker, Sheila Kelly, Warren J Cantor, Shamir R Mehta, Akshay Bagai, Shaun G Goodman, Asim N Cheema
OBJECTIVES: Patients undergoing PCI early after fibrinolytic therapy are at high risk for both thrombotic and bleeding complications. We sought to assess the pharmacodynamic effects of ticagrelor versus clopidogrel in the fibrinolytic-treated STEMI patients undergoing early PCI. METHODS AND RESULTS: Patients undergoing PCI within 24 hours of tenecteplase (TNK), aspirin, and clopidogrel for STEMI were randomized to receive additional clopidogrel 300 mg followed by 75 mg daily or ticagrelor 180 mg followed by 90 mg twice daily...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28938955/cumulative-psychological-stress-and-cardiovascular-disease-risk-in-middle-aged-and-older-women-rationale-design-and-baseline-characteristics
#17
REVIEW
Michelle A Albert, Eva M Durazo, Natalie Slopen, Alan M Zaslavsky, Julie E Buring, Ted Silva, Daniel Chasman, David R Williams
Although a growing body of evidence indicates strong links between psychological stress (stress) and untoward cardiovascular disease (CVD) outcomes, comprehensive examination of these effects remains lacking. The "Cumulative Psychological Stress and Cardiovascular Disease Risk in Middle Aged and Older Women" study is embedded within the landmark Women's Health Study (WHS) follow-up cohort and seeks to evaluate the individual and joint effects of stressors (cumulative stress) on incident CVD risk, including myocardial infarction, stroke, coronary revascularization and CVD death...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28888276/protocol-changes-to-the-triumph-study
#18
LETTER
Ruth Webster
No abstract text is available yet for this article.
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28888275/mean-arterial-pressure-of-65-mm-hg-versus-85-100-mm-hg-in-comatose-survivors-after-cardiac-arrest-rationale-and-study-design-of-the-neuroprotect-post-cardiac-arrest-trial
#19
RANDOMIZED CONTROLLED TRIAL
Koen Ameloot, Cathy De Deyne, Bert Ferdinande, Matthias Dupont, Pieter-Jan Palmers, Thibault Petit, Ward Eertmans, Clara Moonen, Ann Belmans, Robin Lemmens, Joseph Dens, Stefan Janssens
BACKGROUND: Post-cardiac arrest (CA) patients admitted to the intensive care unit (ICU) have a poor prognosis, with estimated survival rates of around 30%-50%. On admission, these patients have a large cerebral penumbra at risk for additional damage in case of suboptimal brain oxygenation during their stay in the ICU. The aim of the Neuroprotect post-CA trial is to investigate whether forcing mean arterial blood pressure (MAP) and mixed venous oxygen saturation (SVO2) in a specific range (MAP 85-100 mm Hg, SVO2 65%-75%) with additional pharmacological support (goal-directed hemodynamic optimization) may better salvage the penumbra, reduce cerebral ischemia, and improve functional outcome when compared with current standard of care (MAP 65 mm Hg)...
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28888274/blood-pressure-reactivity-to-psychological-stress-is-associated-with-clinical-outcomes-in-patients-with-heart-failure
#20
MULTICENTER STUDY
Andrew Sherwood, LaBarron K Hill, James A Blumenthal, Kirkwood F Adams, Nicola J Paine, Gary G Koch, Christopher M O'Connor, Kristy S Johnson, Alan L Hinderliter
INTRODUCTION: Cardiovascular (CV) reactivity to psychological stress has been implicated in the development and exacerbation of cardiovascular disease (CVD). Although high CV reactivity traditionally is thought to convey greater risk of CVD, the relationship between reactivity and clinical outcomes is inconsistent and may depend on the patient population under investigation. The present study examined CV reactivity in patients with heart failure (HF) and its potential association with long-term clinical outcomes...
September 2017: American Heart Journal
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