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American Heart Journal

Peter Nørkjær Laursen, Lene Holmvang, Jacob Lønborg, Lars Køber, Dan E Høfsten, Steffen Helqvist, Peter Clemmensen, Henning Kelbæk, Erik Jørgensen, Jens Flensted Lassen, Frants Pedersen, Thomas Høi-Hansen, Christian Juhl Therkelsen, Hans-Henrik Tilsted, Lisette Okkels Jensen, Lars Nepper-Christensen, Golnaz Sadjadieh, Thomas Engstrøm
BACKGROUND: The objective was to compare patients with ischemic heart disease (IHD) undergoing percutaneous coronary intervention (PCI) who were included in randomized controlled trials (RCTs) (trial participants) with patients who were not included (nonparticipants) on a trial-by-trial basis and according to indication for PCI. METHODS: In this cohort study, we compared patients with IHD who were randomized in RCTs in relation to undergoing PCI in Denmark between 2011 and 2015 were considered as RCT-participants in this study...
August 10, 2018: American Heart Journal
Linzi Li, Elizabeth Selvin, Pamela L Lutsey, Ron C Hoogeveen, Wesley T O'Neal, Elsayed Z Soliman, Lin Y Chen, Alvaro Alonso
BACKGROUND: Circulating N-terminal pro B-type natriuretic peptide (NT-proBNP) predicts incidence of atrial fibrillation (AF), but the association of longitudinal changes in NT-proBNP concentrations with incident AF has not been explored. METHODS: We studied 9705 individuals without prevalent AF in 1996-1998 and with available NT-proBNP measurements obtained in samples collected during two visits in 1990-1992 (visit 2) and 1996-1998 (visit 4) in the Atherosclerosis Risk in Communities (ARIC) Study...
August 9, 2018: American Heart Journal
Tiffany Patterson, Alexander Perkins, Gavin D Perkins, Tim Clayton, Richard Evans, Hanna Nguyen, Karen Wilson, Mark Whitbread, Johanna Hughes, Rachael T Fothergill, Joanne Nevett, Iris Mosweu, Paul McCrone, Miles Dalby, Roby Rakhit, Philip MacCarthy, Divaka Perera, Jerry P Nolan, Simon R Redwood
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) is a global public health issue. There is wide variation in both regional and inter-hospital survival rates from OHCA and overall survival remains poor at 7%. Regionalization of care into cardiac arrest centers (CAC) improves outcomes following cardiac arrest from ST elevation myocardial infarction (STEMI) through concentration of services and greater provider experience. The International Liaison Committee on Resuscitation (ILCOR) recommends delivery of all post-arrest patients to a CAC, but that randomized controlled trials are necessary in patients without ST elevation (STE)...
August 6, 2018: American Heart Journal
Sophie E Claudel, Joel Adu-Brimpong, Alnesha Banks, Colby Ayers, Michelle A Albert, Sandeep R Das, James A de Lemos, Tammy Leonard, Ian J Neeland, Joshua P Rivers, Tiffany M Powell-Wiley
BACKGROUND: Cardiovascular disease is a leading economic and medical burden in the United States (US). As an important risk factor for cardiovascular disease, hypertension represents a critical point of intervention. Less is known about longitudinal effects of neighborhood deprivation on blood pressure outcomes, especially in light of new hypertension guidelines. METHODS: Longitudinal data from the Dallas Heart Study facilitated multilevel regression analysis of the relationship between neighborhood deprivation, blood pressure change, and incident hypertension over a 9-year period...
August 6, 2018: American Heart Journal
Borislav Dinov, Sabrina Oebel, Sebastian Hilbert, Susanne Loebe, Arash Arya, Andreas Bollmann, Philipp Sommer, Cosima Jahnke, Ingo Paetsch, Gerhard Hindricks
BACKGROUND: In human patients, studies about the cardiac magnetic resonance (CMR) appearance of the acute radiofrequency (RF) lesions in relation to the procedural outcomes after catheter ablation (CA) of ventricular arrhythmias (VA) are scarce. We aimed to investigate the RF lesions characteristics in relation to the procedural success. METHODS: Patients referred for ablation of VA received CMR (1.5 T) using gadolinium contrast before and after ablation. CA in left ventricle was performed using a 3...
August 2, 2018: American Heart Journal
Faye L Norby, Lin Y Chen, Elsayed Z Soliman, Rebecca F Gottesman, Thomas H Mosley, Alvaro Alonso
BACKGROUND: Left ventricular hypertrophy (LVH) is an indicator of organ damage largely due to hypertension. We assessed whether LVH was associated with dementia and cognitive function in the Atherosclerosis Risk in Communities study. METHODS: Our analysis included 12,665 individuals (23% black race, 56% female, mean age 57) who attended visit 2 in 1990-1992. Cornell voltage (SV3 + RaVL) was derived from 12-lead electrocardiograms and dichotomized as LVH using sex-specific criteria (>28 mm men; >22 mm women)...
August 2, 2018: American Heart Journal
William J Davison, Phyo K Myint, Allan B Clark, Lois G Kim, Edward C Wilson, Maggie Langley, John F Potter
The therapeutic benefit of self-monitoring blood pressure in stroke patients is uncertain. We investigated the effect of self-monitoring with or without guided antihypertensive management compared with usual care in patients with a recent cerebrovascular event. No between-group differences in blood pressure at outcome were found, but blood pressure self-monitoring and management was well tolerated.
July 27, 2018: American Heart Journal
Nuccia Morici, Fabrizio Oliva, Silvia Ajello, Miriam Stucchi, Alice Sacco, Manlio Gianni Cipriani, Michele De Bonis, Andrea Garascia, Maria Pia Gagliardone, Giulio Melisurgo, Claudio Francesco Russo, Carlo La Vecchia, Maria Frigerio, Federico Pappalardo
Management of acute decompensated heart failure patients presenting with cardiogenic shock (CS) is not straightforward, as few data are available from clinical trials. Stabilization before left ventricle assist device (LVAD) or heart transplantation (HTx) is strongly advocated, as patients undergoing LVAD implant or HTx in critical status have worse outcomes. This was a multicenter phase II study with a Simon 2-stage design, including 24 consecutive patients treated with low-moderate epinephrine doses, whose refractory CS prompted implantation of intra-aortic balloon pump (IABP) which was subsequently upgraded with peripheral venoarterial extracorporeal membrane oxygenation...
July 20, 2018: American Heart Journal
Robert J Mentz, Christopher M O'Connor, Bradi B Granger, Hongqiu Yang, Chetan B Patel, Karen E Steinhauser, Mona Fiuzat, Kimberly S Johnson, Kevin J Anstrom, Gwen C Dodson, Donald H Taylor, Daniel B Mark, James A Tulsky, Joseph G Rogers
No abstract text is available yet for this article.
July 20, 2018: American Heart Journal
Geoff Strange, David S Celermajer, Tom Marwick, David Prior, Marcus Ilton, Jim Codde, Gregory M Scalia, Simon Stewart, Max Bulsara, Eli Gabbay, David Playford
The National Echocardiography Database Australia (NEDA) is a new echocardiography database collecting digital measurements on both a retrospective and prospective basis. To date, echocardiographic data from 435,133 individuals (aged 61.6 ± 17.9 years) with linkage to 59,725 all-cause deaths during a median of 40 months follow-up have been collected. These data will inform a number of initial analyses focusing on pulmonary hypertension, aortic stenosis and the role of artificial intelligence to facilitate accurate diagnoses of cardiac abnormalities...
July 17, 2018: American Heart Journal
Lida Feyz, Nahid El Faquir, Miguel E Lemmert, Karan Ramdat Misier, Laurens J C van Zandvoort, Ricardo P J Budde, Eric Boersma, Felix Zijlstra, Peter de Jaegere, Nicolas M Van Mieghem, Joost Daemen
BACKGROUND: Dedicated data on the prevalence of incidental findings (IF) stratified according to overall clinical relevance and their subsequent correlation to outcome are lacking. The aim of the present study was to describe the prevalence and consequences of noncardiac IF on computed tomography or magnetic resonance imaging in the workup for interventional cardiovascular procedures. METHODS: A total of 916 patients underwent preprocedural computed tomography or magnetic resonance imaging in the workup for transcatheter aortic valve implantation (TAVI), renal sympathetic denervation (RDN), or MitraClip implantation...
July 12, 2018: American Heart Journal
Elizabeth R Stevens, Daniel Farrell, Saahil A Jumkhawala, Joseph A Ladapo
BACKGROUND: The American College of Cardiology/American Heart Association (ACC/AHA) recently published a rigorous framework to guide integration of economic data into clinical guidelines. We assessed the quality of economic evaluations in a major ACC/AHA clinical guidance report. METHODS: We systematically identified cost-effectiveness analyses (CEAs) of RCTs cited in the ACC/AHA 2012 Guideline for the Diagnosis and Management of Patients with Stable Ischemic Heart Disease...
July 11, 2018: American Heart Journal
Sandra Korol, Michel White, Eileen O'Meara, François Tournoux, Normand Racine, Anique Ducharme, Jean-Lucien Rouleau, Mark Liszkowski, Asmaa Mansour, Martin Jutras, Marie-Claude Guertin, Mathieu Bernier, Joël Lavoie, Grégoire Leclair, Paul-Eduard Neagoe, Diana Chaar, Martin G Sirois, Simon de Denus
Mineralocorticoid receptor antagonists (MRAs) decrease morbidity and mortality in patients with heart failure (HF). However, spironolactone, a non-selective MRA, has been shown to exert a harmful effect on glucose homeostasis. The objective of this multicenter, randomized, controlled, double-blind trial was to compare the effects of spironolactone to those of the selective MRA eplerenone on glucose homeostasis among 62 HF patients with glucose intolerance or type II diabetes. TRIAL REGISTRATION NUMBER: NCT01586442...
July 10, 2018: American Heart Journal
Steven J Keteyian, Dennis J Kerrigan, Barry Lewis, Jonathan K Ehrman, Clinton A Brawner
BACKGROUND: In patients with coronary heart disease, the exercise workload (i.e., metabolic equivalents of task, METs) at which patients exercise train upon entry and completion of cardiac rehabilitation (CR) are independently related to prognosis. Unknown is the association between exercise training workloads in CR and clinical outcomes in patients with heart failure (HF). METHODS: Patients with HF who participated in an early outpatient CR program were used in this retrospective analysis...
July 10, 2018: American Heart Journal
Raymond J Gibbons, William S Weintraub, Ralph G Brindis
IMPORTANCE: Although percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) are both commonly employed in the treatment of stable ischemic heart disease (SIHD), their ability to reduce subsequent heart attacks and death is currently in question. These procedures will come under increasing scrutiny as the healthcare reimbursement system moves away from the traditional fee for service model in favor of "pay for value". OBSERVATION: Both international and domestic data show wide variability in the use of PCI and CABG in patients with SIHD...
July 10, 2018: American Heart Journal
Anna Gundlund, Thomas Kümler, Jonas Bjerring Olesen, Anders Nissen Bonde, Gunnar H Gislason, Christian Torp-Pedersen, Lars Køber, Emil Loldrup Fosbøl
BACKGROUND: The aim of this study was to compare long-term thromboembolic risk in infection-related and non-infection-related atrial fibrillation (AF). METHODS: Using Danish nationwide registries, we identified patients with first-time AF from 1996-2015 and performed a retrospective cohort study. We did a 1:1 match (upon sex, age, calendar year, and oral anticoagulation (OAC) status at the beginning of follow-up) of patients with infection-related (concurrent discharge diagnosis code for infection) and non-infection-related AF...
July 10, 2018: American Heart Journal
Sarah Hugelshofer, Marco Roffi, Fabienne Witassek, Franz R Eberli, Thomas Pilgrim, Giovanni Pedrazzini, Hans Rickli, Dragana Radovanovic, Paul Erne, Sophie Degrauwe, Olivier Muller, Pier Giorgio Masci, Stephan Windecker, Juan F Iglesias
BACKGROUND: The benefits of manual thrombus aspiration (TA) during primary percutaneous coronary intervention (pPCI) for ST-elevation myocardial infarction (STEMI) remain uncertain. We assessed the influence of total ischemic time (TIT) on clinical outcomes among STEMI patients undergoing manual TA during pPCI. METHODS AND RESULTS: We conducted a retrospective study of patients enrolled in the Acute Myocardial Infarction in Switzerland Plus registry. STEMI patients undergoing pPCI with (TA group) or without (PCI-alone group) manual TA were stratified based on short (<3 hours), intermediate (3-6 hours), and long (>6 hours) TIT...
July 10, 2018: American Heart Journal
Matthew W Sherwood, Sreekanth Vemulapalli, John Kevin Harrison, David Dai, Amit N Vora, Michael J Mack, David R Holmes, John S Rumsfeld, David J Cohen, Vinod H Thourani, Ajay Kirtane, Eric D Peterson
BACKGROUND: Dual antiplatelet therapy (DAPT) is recommended following transcatheter aortic valve replacement (TAVR); however, the optimal antiplatelet strategy is undefined, and little is known about practice patterns. We aimed to describe contemporary practice patterns of antiplatelet therapy and their relationship to outcomes post-TAVR. METHODS: The population was derived from the National Cardiovascular Data Registry, Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry with Center for Medical Services linkage for 1-year outcomes from October 1, 2011 to June 30,2016...
July 9, 2018: American Heart Journal
Danielle M Gualandro, Christian Puelacher, Giovanna LuratiBuse, Andreas Lampart, Celia Strunz, Francisco A Cardozo, Pai C Yu, Allan S Jaffe, Sanela Barac, Lukas Bock, Patrick Badertscher, Jeanne du Fay de Lavallaz, Stella Marbot, Lorraine Sazgary, Daniel Bolliger, Katharina Rentsch, Raphael Twerenbold, Angelika Hammerer-Lercher, Edielle S Melo, Daniela Calderaro, Alberto Js Duarte, Nelson de Luccia, Bruno Caramelli, Christian Mueller
BACKGROUND: We aimed to directly compare preoperative high-sensitivity cardiac troponin (hs-cTn) I and T concentration for the prediction of major cardiac complications after non-cardiac surgery. METHODS: We measured hs-cTnI and hs-cTnT preoperatively in a blinded fashion in 1022 patients undergoing non-cardiac surgery. The primary endpoint was a composite of major cardiac complications including cardiac death, cardiac arrest, myocardial infarction, clinically relevant arrhythmias, and acute heart failure within 30 days...
July 5, 2018: American Heart Journal
Sonali R Gnanenthiran, John Yiannikas, Harry C Lowe, David Brieger, Sandhya Limaye
Dual antiplatelet therapy, consisting of aspirin and a P2Y12 receptor antagonist, has been the cornerstone of management in those undergoing percutaneous coronary intervention, reducing stent thromboses and cardiovascular events. Given the pivotal role of aspirin in cardiovascular disease management, patients with aspirin hypersensitivity pose complex clinical challenges. Allergy to aspirin is reported in 1.5-2.6% of patients presenting with cardiac disease. Identification of the subtype of aspirin hypersensitivity will determine suitability for aspirin desensitization, dictate choice of desensitization protocol and inform risk management...
July 4, 2018: American Heart Journal
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