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American Heart Journal

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https://www.readbyqxmd.com/read/27979047/statin-therapy-and-low-density-lipoprotein-cholesterol-reduction-in-hiv-infected-individuals-after-acute-coronary-syndrome-results-from-the-pacs-hiv-lipids-substudy
#1
Franck Boccara, Joe Miantezila Basilua, Murielle Mary-Krause, Sylvie Lang, Emmanuel Teiger, Philippe Gabriel Steg, Christian Funck-Brentano, Pierre-Marie Girard, Dominique Costagliola, Ariel Cohen, Marguerite Guiguet
: Knowledge about lipid interventions in secondary prevention in HIV-infected individuals is limited; studies are sparse. METHODS: A prospective observational multicenter study enrolled 282 patients on statin 1 month after first acute coronary syndrome (ACS) (95 HIV-infected individuals, 187 HIV-uninfected). Data on fasting lipids (total cholesterol [TC], low-density lipoprotein cholesterol, high-density lipoprotein cholesterol [HDL-C], non-HDL-C, triglycerides, TC/HDL-C ratio) were collected over 3 years...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979046/effects-of-exercise-and-stress-management-training-on-nighttime-blood-pressure-dipping-in-patients-with-coronary-heart-disease-a-randomized-controlled-trial
#2
Andrew Sherwood, Patrick J Smith, Alan L Hinderliter, Anastasia Georgiades, James A Blumenthal
INTRODUCTION: Blunted nighttime blood pressure (BP) dipping is prognostic of cardiovascular morbidity and mortality. Patients with coronary heart disease (CHD) are often characterized by a blunted nighttime BP dipping pattern. The present study compared the effects of 2 behavioral intervention programs, aerobic exercise (EX) and stress management (SM) training, with a usual care (UC) control group on BP dipping in a sample of CHD patients. METHODS: This was a secondary analysis of a randomized, controlled trial with allocation concealment and blinded outcome assessment in 134 patients with stable CHD and exercise-induced myocardial ischemia...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979045/sex-differences-in-lipid-profiles-and-treatment-utilization-among-young-adults-with-acute-myocardial-infarction-results-from-the-virgo-study
#3
Yuan Lu, Shengfan Zhou, Rachel P Dreyer, Michael Caulfield, Erica S Spatz, Mary Geda, Nancy P Lorenze, Peter Herbert, Gail D'Onofrio, Elizabeth A Jackson, Judith H Lichtman, Héctor Bueno, John A Spertus, Harlan M Krumholz
BACKGROUND: Young women with acute myocardial infarction (AMI) have higher mortality risk than similarly aged men. An adverse lipid profile is an important risk factor for cardiovascular outcomes after AMI, but little is known about whether young women with AMI have a higher-risk lipid pattern than men. We characterized sex differences in lipid profiles and treatment utilization among young adults with AMI. METHODS: A total of 2,219 adults with AMI (1,494 women) aged 18-55 years were enrolled from 103 hospitals in the United States (2008-2012)...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979044/serum-brain-derived-neurotrophic-factor-and-risk-of-atrial-fibrillation
#4
Faisal Rahman, Jayandra J Himali, Xiaoyan Yin, Alexa S Beiser, Patrick T Ellinor, Steven A Lubitz, Ramachandran S Vasan, Jared W Magnani, David D McManus, Sudha Seshadri, Emelia J Benjamin
: Brain-derived neurotrophic factor (BDNF) is expressed by endothelial cells and can affect cardiovascular function. We examined if serum BDNF was associated with risk of incident atrial fibrillation (AF) in the Framingham Heart Study. METHODS: We studied individuals without an AF diagnosis at baseline from the Framingham original and offspring cohorts. We used age- and sex-adjusted, and multivariable-adjusted Cox proportional hazards regression models to examine the association of serum BDNF concentrations with 10-year risk of incident AF...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979043/switching-of-adenosine-diphosphate-receptor-inhibitor-after-hospital-discharge-among-myocardial-infarction-patients-insights-from-the-treatment-with-adenosine-diphosphate-receptor-inhibitors-longitudinal-assessment-of-treatment-patterns-and-events-after-acute
#5
Marjorie E Zettler, Eric D Peterson, Lisa A McCoy, Mark B Effron, Kevin J Anstrom, Timothy D Henry, Brian A Baker, John C Messenger, David J Cohen, Tracy Y Wang
: The reasons for postdischarge adenosine diphosphate receptor inhibitor (ADPri) switching among patients with myocardial infarction (MI) are unclear. We sought to describe the incidence and patterns of postdischarge ADPri switching among patients with acute MI treated with percutaneous coronary intervention. METHODS: We used TRANSLATE-ACS (2010-2012) data to assess postdischarge ADPri switching among 8,672 MI patients discharged after percutaneous coronary intervention who remained on ADPri therapy 1 year post-MI...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979042/socioeconomic-and-partner-status-in-chronic-heart-failure-relationship-to-exercise-capacity-quality-of-life-and-clinical-outcomes
#6
Amanda K Verma, Phillip J Schulte, Vera Bittner, Steven J Keteyian, Jerome L Fleg, Ileana L Piña, Ann M Swank, Meredith Fitz-Gerald, Stephen J Ellis, William E Kraus, David J Whellan, Christopher M O'Connor, Robert J Mentz
BACKGROUND: Prognosis in patients with heart failure (HF) is commonly assessed based on clinical characteristics. The association between partner status and socioeconomic status (SES) and outcomes in chronic HF requires further study. METHODS: We performed a post hoc analysis of HF-ACTION, which randomized 2,331 HF patients with ejection fraction ≤35% to usual care ± aerobic exercise training. We examined baseline quality of life and functional capacity and outcomes (all-cause mortality/hospitalization) by partner status and SES using adjusted Cox models and explored an interaction with exercise training...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979041/acute-cardioversion-vs-a-wait-and-see-approach-for-recent-onset-symptomatic-atrial-fibrillation-in-the-emergency-department-rationale-and-design-of-the-randomized-acwas-trial
#7
Elton Dudink, Brigitte Essers, Wouter Holvoet, Bob Weijs, Justin Luermans, Hemanth Ramanna, Anho Liem, Jurren van Opstal, Lukas Dekker, Vincent van Dijk, Timo Lenderink, Otto Kamp, Lennert Kulker, Michiel Rienstra, Bas Kietselaer, Marco Alings, Jos Widdershoven, Joan Meeder, Martin Prins, Isabelle van Gelder, Harry Crijns
BACKGROUND: Current standard of care for patients with recent-onset atrial fibrillation (AF) in the emergency department aims at urgent restoration of sinus rhythm, although paroxysmal AF is a condition that resolves spontaneously within 24 hours in more than 70% of the cases. A wait-and-see approach with rate-control medication only and when needed cardioversion within 48 hours of onset of symptoms is hypothesized to be noninferior, safe, and cost-effective as compared with current standard of care and to lead to a higher quality of life...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979040/validation-of-an-automated-electronic-algorithm-and-dashboard-to-identify-and-characterize-decompensated-heart-failure-admissions-across-a-medical-center
#8
Zachary L Cox, Connie M Lewis, Pikki Lai, Daniel J Lenihan
BACKGROUND: We aim to validate the diagnostic performance of the first fully automatic, electronic heart failure (HF) identification algorithm and evaluate the implementation of an HF Dashboard system with 2 components: real-time identification of decompensated HF admissions and accurate characterization of disease characteristics and medical therapy. METHODS: We constructed an HF identification algorithm requiring 3 of 4 identifiers: B-type natriuretic peptide >400 pg/mL; admitting HF diagnosis; history of HF International Classification of Disease, Ninth Revision, diagnosis codes; and intravenous diuretic administration...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979039/usefulness-of-cell-mediated-immune-function-in-risk-stratification-for-patients-with-advanced-heart-failure
#9
Vijaiganesh Nagarajan, Adrian V Hernandez, Clay A Cauthen, Randall C Starling, W H Wilson Tang
: Although heightened inflammation and autoimmune responses have been well described in patients with heart failure, the role of cell-mediated immune function in the pathogenesis and progression of heart failure is unclear. The aim of our study is to evaluate the prognostic role of cell-mediated immune function in patients with advanced heart failure. METHODS: We studied patients with advanced heart failure referred for evaluation of candidacy for advanced heart failure therapies between 2007 and 2010...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979038/baseline-assessment-and-comparison-of-arterial-anatomy-hyperemic-flow-and-skeletal-muscle-perfusion-in-peripheral-artery-disease-the-cardiovascular-cell-therapy-research-network-patients-with-intermittent-claudication-injected-with-aldh-bright-cells-cctrn-pace
#10
Bharath Ambale Venkatesh, Victor Nauffal, Chikara Noda, Tomoki Fujii, Phillip C Yang, Judy Bettencourt, Erin P Ricketts, Michael Murphy, Nicholas J Leeper, Lem Moyé, Ray F Ebert, Raja Muthupillai, David A Bluemke, Emerson C Perin, Alan T Hirsch, João A C Lima
BACKGROUND: Peripheral artery disease (PAD) is important to public health as a major contributor to cardiovascular morbidity and mortality. Recent developments in magnetic resonance imaging (MRI) techniques permit improved assessment of PAD anatomy and physiology, and may serve as surrogate end points after proangiogenic therapies. METHODS: The PACE study is a randomized, double-blind, placebo-controlled clinical trial designed to assess the physiologic impact and potential clinical efficacy of autologous bone marrow-derived ALDH(br) stem cells...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979037/chocolate-intake-and-incidence-of-heart-failure-findings-from-the-cohort-of-swedish-men
#11
Daniel A Steinhaus, Elizabeth Mostofsky, Emily B Levitan, Kirsten S Dorans, Niclas Håkansson, Alicja Wolk, Murray A Mittleman
: The objective of this study was to evaluate the association of chocolate consumption and heart failure (HF) in a large population of Swedish men. METHODS: We conducted a prospective cohort study of 31,917 men 45-79 years old with no history of myocardial infarction, diabetes, or HF at baseline who were participants in the population-based Cohort of Swedish Men study. Chocolate consumption was assessed through a self-administrated food frequency questionnaire. Participants were followed for HF hospitalization or mortality from January 1, 1998, to December 31, 2011, using record linkage to the Swedish inpatient and cause-of-death registries...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979036/relationship-between-hospital-procedure-volume-and-complications-following-congenital-cardiac-catheterization-a-report-from-the-improving-pediatric-and-adult-congenital-treatment-impact-registry
#12
Natalie Jayaram, John A Spertus, Michael L O'Byrne, Paul S Chan, Kevin F Kennedy, Lisa Bergersen, Andrew C Glatz
BACKGROUND: The association between institutional volume and outcomes has been demonstrated for cardiac catheterization among adults, but less is known about this relationship for patients with congenital heart disease (CHD) undergoing cardiac catheterization. METHODS: Within the IMPACT registry, we identified all catheterizations between January 2011 and March 2015. Hierarchical logistic regression, adjusted for patient and procedural characteristics, was used to determine the association between annual catheterization lab volume and occurrence of a major adverse event (MAE)...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979035/extending-the-volume-outcomes-debate-into-the-world-of-congenital-cardiac-catheterization
#13
EDITORIAL
Kevin D Hill
No abstract text is available yet for this article.
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979034/interventional-left-atrial-appendage-closure-vs-novel-anticoagulation-agents-in-patients-with-atrial-fibrillation-indicated-for-long-term-anticoagulation-prague-17-study
#14
Pavel Osmancik, Petr Tousek, Dalibor Herman, Petr Neuzil, Pavel Hala, Josef Stasek, Ludek Haman, Petr Kala, Martin Poloczek, Marian Branny, Jan Chovancik, Pavel Cervinka, Jiri Holy, Vlastimil Vancura, Richard Rokyta, Milos Taborsky, Tomas Kovarnik, David Zemanek, Petr Peichl, Sarka Haskova, Jiri Jarkovsky, Petr Widimsky
: Atrial fibrillation (AF), with a prevalence of 1% to 2%, is the most common cardiac arrhythmia. Without antithrombotic treatment, the annual risk of a cardioembolic event is 5% to 6%. The source of a cardioembolic event is a thrombus, which is usually formed in the left atrial appendage (LAA). Prevention of cardioembolic events involves treatment with anticoagulant drugs: either vitamin K antagonists or, recently, novel oral anticoagulants (NOAC). The other (nonpharmacologic) option for the prevention of a cardioembolic event involves interventional occlusion of the LAA...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979033/bendopnea-and-risk-of-adverse-clinical-outcomes-in-ambulatory-patients-with-systolic-heart-failure
#15
Jennifer T Thibodeau, Benjamin E Jenny, Jeomi O Maduka, Punag H Divanji, Colby R Ayers, Faris Araj, Alpesh A Amin, Robert M Morlend, Pradeep P A Mammen, Mark H Drazner
BACKGROUND: Recently, the symptom of bendopnea, that is, shortness of breath when bending forwards such as when putting on shoes, has been described in heart failure patients and found to be associated with higher ventricular filling pressures, particularly in the setting of low cardiac index. However, it is not known whether bendopnea is associated with clinical outcomes. METHODS: In a prospective convenience sample of 179 patients followed in our heart failure disease management clinic, we determined the presence of bendopnea at the time of enrollment and ascertained clinical outcomes through 1 year of follow-up...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979032/prevalence-and-outcome-of-thrombotic-and-embolic-complications-in-adults-after-fontan-operation
#16
Alexander C Egbe, Heidi M Connolly, Talha Niaz, Vidhushei Yogeswaran, Nathaniel W Taggart, Muhammad Y Qureshi, Joseph T Poterucha, Arooj Razzaq Khan, David J Driscoll
: There are limited studies of thrombotic and embolic complications (TEC) in the adult Fontan population. The purpose of the study was to determine the prevalence, risk factors, and outcomes of TECs in this population. METHODS: Retrospective review of adults with a previous Fontan operation, with follow-up at Mayo Clinic, 1994-2014. Systemic TEC was defined as intracardiac thrombus, ischemic stroke, or systemic arterial embolus. Nonsystemic TEC was defined as Fontan conduit/right atrial thrombus or pulmonary embolus...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27979031/clinical-value-of-post-percutaneous-coronary-intervention-fractional-flow-reserve-value-a-systematic-review-and-meta-analysis
#17
REVIEW
Goran Rimac, William F Fearon, Bernard De Bruyne, Fumiaki Ikeno, Hitoshi Matsuo, Zsolt Piroth, Olivier Costerousse, Olivier F Bertrand
BACKGROUND: Fractional flow reserve (FFR) prior to percutaneous coronary intervention (PCI) is useful to guide treatment. Whether post-PCI FFR assessment might have clinical impact is controversial. The aim of this study is to evaluate the range of post-PCI FFR values and analyze the relationship between post-PCI FFR and clinical outcomes. METHODS: We systematically searched the PubMed, EMBASE, and Cochrane Library databases with cross-referencing of articles reporting post-PCI FFR and correlating post-PCI FFR values and clinical outcomes...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27302626/b-type-natriuretic-peptide-and-plasma-hemoglobin-levels-following-transfusion-of-shorter-storage-versus-longer-storage-red-blood-cells-results-from-the-total-randomized-trial
#18
Aggrey Dhabangi, Brenda Ainomugisha, Christine Cserti-Gazdewich, Henry Ddungu, Dorothy Kyeyune, Ezra Musisi, Robert Opoka, Christopher P Stowell, Walter H Dzik
BACKGROUND: Prior studies have suggested that transfusion of stored red blood cells (RBCs) with increased levels of cell-free hemoglobin might reduce the bioavailability of recipient nitric oxide (NO) and cause myocardial strain. METHODS: Ugandan children (ages 6-60 months) with severe anemia and lactic acidosis were randomly assigned to receive RBCs stored 1-10 days versus 25-35 days. B-type natriuretic peptide (BNP), vital signs, renal function test results, and plasma hemoglobin were measured...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27914506/use-of-high-intensity-statins-for-patients-with-atherosclerotic-cardiovascular-disease-in-the-veterans-affairs-health-system-practice-impact-of-the-new-cholesterol-guidelines
#19
Fatima Rodriguez, Shoutzu Lin, David J Maron, Joshua W Knowles, Salim S Virani, Paul A Heidenreich
BACKGROUND: The November 2013 American College of Cardiology/American Heart Association cholesterol guidelines recommend the use of high-intensity statins for patients with atherosclerotic cardiovascular disease (ASCVD). We sought to determine how these guidelines are being adopted at the Veterans Affairs (VA) Health System and identify treatment gaps. METHODS: We examined administrative data from the VA 12 months prior to the index dates of April 1, 2013, and after April 1, 2014, to identify patients ≤75 years of age with ≥2 codes for ASCVD...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27914505/temporal-trends-and-factors-associated-with-diabetes-mellitus-among-patients-hospitalized-with-heart-failure-findings-from-get-with-the-guidelines-heart-failure-registry
#20
Justin B Echouffo-Tcheugui, Haolin Xu, Adam D DeVore, Phillip J Schulte, Javed Butler, Clyde W Yancy, Deepak L Bhatt, Adrian F Hernandez, Paul A Heidenreich, Gregg C Fonarow
BACKGROUND: The contribution of diabetes to the burden of heart failure (HF) remains largely undescribed. Assessing diabetes temporal trends among US patients hospitalized with HF and their relation with quality measures in real-world practice can help to define this burden. METHODS: Using data from the Get With the Guidelines-Heart Failure registry, we assessed temporal trends in diabetes prevalence among patients with HF and in subgroups with reduced ejection fraction (HFrEF; EF < 40%), borderline EF (HFbEF; 40%≤EF <50%), or preserved EF (HFpEF; EF ≥ 50%), hospitalized between 2005 and 2015...
December 2016: American Heart Journal
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