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Acta Psychiatrica Scandinavica

J Obbels, E Verwijk, K Vansteelandt, A Dols, F Bouckaert, S Schouws, M Vandenbulcke, L Emsell, M Stek, P Sienaert
OBJECTIVE: There is ongoing concern about the possible negative impact of ECT on neurocognitive functioning in older patients. In this study, we aimed to characterize the long-term cognitive effects of ECT in patients with late-life depression, using an extensive neuropsychological battery. METHODS: A total of 110 patients aged 55 years and older with unipolar depression, referred for ECT were included. The neuropsychological test battery was assessed prior to ECT and 6 months after the last ECT session...
July 12, 2018: Acta Psychiatrica Scandinavica
A J E Dirkzwager, P Nieuwbeerta
OBJECTIVE: Mental health problems are common in prison populations. Less is known about how mental health problems develop during imprisonment. The objective was to examine the longitudinal course of mental health symptoms during imprisonment and individual factors associated with the development of these symptoms. METHOD: In a prospective cohort study, 1.664 Dutch male prisoners were questioned 3 weeks after their arrival in detention. Those still in custody were questioned again after 3, 9, and 18 months...
July 12, 2018: Acta Psychiatrica Scandinavica
N Warren, D Siskind, C O'Gorman
OBJECTIVE: To review the psychiatric symptoms of anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, in an attempt to differentiate the presentation from a primary psychiatric disorder. METHOD: A systematic literature review of PubMed and EMBASE of all published cases of anti-NMDA receptor encephalitis was performed from inception to January 2018. RESULTS: There were 706 cases of anti-NMDA receptor encephalitis identified. Cases were typically young (mean age 22...
July 10, 2018: Acta Psychiatrica Scandinavica
P Bucci, S Galderisi, A Mucci, A Rossi, P Rocca, A Bertolino, E Aguglia, M Amore, I Andriola, A Bellomo, M Biondi, A Cuomo, L dell'Osso, A Favaro, F Gambi, G M Giordano, P Girardi, C Marchesi, P Monteleone, C Montemagni, C Niolu, L Oldani, F Pacitti, F Pinna, R Roncone, A Vita, P Zeppegno, M Maj
OBJECTIVE: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. METHOD: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored...
July 8, 2018: Acta Psychiatrica Scandinavica
P S Ritter, J Schwabedal, M Brandt, W Schrempf, F Brezan, A Krupka, C Sauer, A Pfennig, M Bauer, B Soltmann, E Nikitin
OBJECTIVE: Bipolar disorder is a severe mental disorder for which currently no reliable biomarkers exist. It has been shown that patients with schizophrenia but not with unipolar depression have a reduced density of fast sleep spindles during N2 sleep. The aim of this study was to assess fast sleep spindle density in euthymic patients with bipolar disorder. METHODS: Patients with bipolar disorder (n = 24) and healthy control subjects (n = 25) were assessed using all-night polysomnography...
July 4, 2018: Acta Psychiatrica Scandinavica
C Dondé, P Vignaud, E Poulet, J Brunelin, F Haesebaert
OBJECTIVES: Depression is a frequent but potentially treatable clinical dimension in patients with schizophrenia spectrum disorders (PWS). However, there is a lack of consensual recommendations regarding the optimal strategy to manage depression in PWS. In this study, we aimed to compare the various proposed strategies to define a core set of valid care recommendations for depression management in PWS. METHODS: After a systematic search of the literature, the methodological quality of 10 international guidelines from four continents was compared using a validated guideline appraisal instrument (AGREE II)...
July 4, 2018: Acta Psychiatrica Scandinavica
K S Bingham, B S Meyers, B H Mulsant, A J Rothschild, E M Whyte, S Banerjee, A S Artis, G S Alexopoulos, A J Flint
OBJECTIVE: We conducted a 12-week double-blind study of stabilization pharmacotherapy in patients with remitted psychotic depression (PD). METHODS: Seventy-one persons aged 18 years or older who had achieved remission of PD when randomized to either olanzapine plus sertraline or olanzapine plus placebo were continued on the double-blind treatment associated with remission. Symptoms of depression and psychosis, and weight, were measured once every 4 weeks. Cholesterol, triglycerides, and glucose were measured at stabilization phase baseline and Week 12/termination...
June 29, 2018: Acta Psychiatrica Scandinavica
Y Quidé, F Andersson, D Dufour-Rainfray, C Descriaud, B Brizard, V Gissot, H Cléry, M-P Carrey Le Bas, S Osterreicher, M Ogielska, P Saint-Martin, W El-Hage
OBJECTIVE: Exposure to sexual assault is a significant risk factor to develop post-traumatic stress disorder (PTSD) in females. The early neurobiological changes leading to the development of PTSD remain understudied and unclear in this population. METHODS: Participants were 27 adult females recruited within a month following exposure to sexual assault (T1) and 20 age-matched non-exposed controls. Among the victims, 10 participants met (PTSD+) and 15 did not meet (PTSD-) DSM-IV criteria for PTSD 6 months post-trauma (T2)...
June 27, 2018: Acta Psychiatrica Scandinavica
D Erritzoe, L Roseman, M M Nour, K MacLean, M Kaelen, D J Nutt, R L Carhart-Harris
OBJECTIVE: To explore whether psilocybin with psychological support modulates personality parameters in patients suffering from treatment-resistant depression (TRD). METHOD: Twenty patients with moderate or severe, unipolar, TRD received oral psilocybin (10 and 25 mg, one week apart) in a supportive setting. Personality was assessed at baseline and at 3-month follow-up using the Revised NEO Personality Inventory (NEO-PI-R), the subjective psilocybin experience with Altered State of Consciousness (ASC) scale, and depressive symptoms with QIDS-SR16...
June 19, 2018: Acta Psychiatrica Scandinavica
C Abé, S Rolstad, P Petrovic, C-J Ekman, T Sparding, M Ingvar, M Landén
OBJECTIVE: Frontal cortical abnormalities and executive function impairment co-occur in bipolar disorder. Recent studies have shown that bipolar subtypes differ in the degree of structural and functional impairments. The relationships between cognitive performance and cortical integrity have not been clarified and might differ across patients with bipolar disorder type I, II, and healthy subjects. METHOD: Using a vertex-wise whole-brain analysis, we investigated how cortical integrity, as measured by cortical thickness, correlates with executive performance in patients with bipolar disorder type I, II, and controls (N = 160)...
June 15, 2018: Acta Psychiatrica Scandinavica
S H Ameis, C Kassee, P Corbett-Dick, L Cole, S Dadhwal, M-C Lai, J Veenstra-VanderWeele, C U Correll
OBJECTIVE: Evidence-based guidance of clinical decision-making for the management of Autism Spectrum Disorder (ASD) is lacking, particularly for co-occurring psychiatric symptoms. This review evaluates treatment evidence for six common symptom targets in children/adolescents with ASD and provides a resource to facilitate application of the evidence to clinical practice. METHOD: A systematic search identified randomized controlled trials (RCTs) and high-quality systematic reviews published between 2007 and 2016, focused on: social interaction/communication impairment, stereotypic/repetitive behaviours, irritability/agitation, attention-deficit/hyperactivity disorder symptoms, mood or anxiety symptoms, and sleep difficulties...
June 14, 2018: Acta Psychiatrica Scandinavica
A Tanskanen, J Tiihonen, H Taipale
OBJECTIVE: Recent reports suggest that the mortality gap between persons with schizophrenia and the general population is increasing. We investigated the mortality, age at death, and causes of death among persons diagnosed with schizophrenia and the general population in Finland during 1984-2014. METHODS: All persons with schizophrenia in Finland were identified from hospital discharge register, and compared with the Finnish population aged 16 years and older during 1984-2014, based on data from Statistics Finland...
June 13, 2018: Acta Psychiatrica Scandinavica
T Bschor, J Henssler, M Müller, C Baethge
OBJECTIVE: To evaluate the efficacy and tolerability of baclofen vs. placebo for long-term treatment of alcohol use disorder. METHOD: Systematic review and meta-analysis following methods of the Cochrane Collaboration Handbook (PROSPERO registration: CRD42017073663). Primary outcome was the random-effects summary estimate of all standardized mean differences (SMDs), as calculated from the primary outcomes of each study. RESULTS: Fourteen double-blind RCTs (1522 patients) were included...
June 10, 2018: Acta Psychiatrica Scandinavica
K W Miskowiak, N A Petersen, C J Harmer, E Ehrenreich, L V Kessing, M Vinberg, J Macoveanu, H R Siebner
OBJECTIVE: Bipolar disorder is associated with impairments in social cognition including the recognition of happy faces. This is accompanied by imbalanced cortico-limbic response to emotional faces. We found that EPO improved the recognition of happy faces in patients with bipolar disorder. This randomized, controlled, longitudinal fMRI study explores the neuronal underpinnings of this effect. METHOD: Forty-four patients with bipolar disorder in full or partial remission were randomized to eight weekly erythropoietin (EPO; 40 000 IU) or saline (NaCl 0...
June 7, 2018: Acta Psychiatrica Scandinavica
R Tamouza, J Oliveira, B Etain, D Bengoufa, N Hamdani, C Manier, C Mariaselvam, A Sundaresh, F Bellivier, C Henry, J-P Kahn, R Krishnamoorthy, D Charron, M Leboyer
OBJECTIVE: Bipolar Disorder (BD) is characterized by deregulated adaptive immune processes. Recent genome-wide association studies (GWAS) implicate the major histocompatibility complex (MHC) region in BD. The present study investigates the potential influence of variations in human leukocyte antigen (HLA) on BD risk and/or clinical presentations. This may have relevance to the dysregulated inflammatory processes commonly found in BD. METHOD: DNAs from 475 BD patients and 195 healthy controls (HC) were genotyped for classical HLA class I and II loci...
June 4, 2018: Acta Psychiatrica Scandinavica
L Tondo, G H Vázquez, M Pinna, P A Vaccotto, R J Baldessarini
OBJECTIVE: To assess differences between subjects with vs. without mixed features in major affective disorders. METHODS: In 3099 out-patient subjects with DSM-5 major depressive disorder (MDD, n = 1921) or bipolar disorders (BD, n = 1178), we compared those with (Mx) vs. without (Non-Mx) mixed features (agitated-irritable depression or dysphoric [hypo]mania) in an index episode. RESULTS: Prevalence of Mx averaged 21.9% [CI: 20.5-23.4] overall, ranking: BD-II > BD-I > MDD, and in BD depression ≥ [hypo]mania > MDD...
June 3, 2018: Acta Psychiatrica Scandinavica
V Tapiainen, H Taipale, A Tanskanen, J Tiihonen, S Hartikainen, A-M Tolppanen
OBJECTIVE: To assess the association between benzodiazepine and related drug (BZDR) use and risk of Alzheimer's disease (AD) with cumulative consumption and duration of use based models. METHOD: A nationwide nested case-control study of all Finnish community-dwelling persons who received clinically verified AD diagnosis in 2005-2011 (N = 70 719) and their matched controls (N = 282 862). AD diagnosis was based on DSM-IV and NINCDS-ADRDA criteria. BZDR purchases were extracted from the Prescription Register since 1995...
May 31, 2018: Acta Psychiatrica Scandinavica
H Brochard, O Godin, P A Geoffroy, S Yeim, C Boudebesse, C Benizri, V Benard, J Maruani, M Leboyer, F Bellivier, B Etain
OBJECTIVE: This study explored the correlations between sleep and circadian rhythm measures and the metabolic syndrome (MetS) components in remitted patients with bipolar disorder (BD). METHOD: Euthymic patients with BD (n = 67) were recorded by 3 weeks with actigraphy. We used nonparametric correlations to study the links between the MetS parameters, atherogenic index of plasma (AIP), sleep efficacy, sleep latency, fragmentation index, and phase and amplitude of rhythms...
May 30, 2018: Acta Psychiatrica Scandinavica
G Kadra, R Stewart, H Shetty, J H MacCabe, C-K Chang, D Taylor, R D Hayes
OBJECTIVES: To investigate the association between long-term antipsychotic polypharmacy use and mortality; and determine whether this risk varies by cause of death and antipsychotic dose. METHODS: Using data from a large anonymised mental healthcare database, we identified all adult patients with serious mental illness (SMI) who had been prescribed a single antipsychotic or polypharmacy, for six or more months between 2007 and 2014. Multivariable Cox regression models were constructed, adjusting for sociodemographic, socioeconomic, clinical factors and smoking, to examine the association between APP use and the risk of death...
May 29, 2018: Acta Psychiatrica Scandinavica
N Myles, H Myles, S Xia, M Large, S Kisely, C Galletly, R Bird, D Siskind
BACKGROUND: Clozapine is associated with life-threatening neutropenia. There are no previous meta-analyses of the epidemiology of clozapine-associated neutropenia. OBJECTIVES: To determine the cumulative incidence of mild, moderate and severe neutropenia, incidence of death related to severe neutropenia, case fatality rate of neutropenia and the longitudinal incidence of neutropenia following exposure to clozapine. DATA SOURCES: A systematic search of Medline, EMBASE and PsycINFO using search terms [clozapine OR clopine OR zaponex OR clozaril] AND [neutropenia OR agranulocytosis]...
May 21, 2018: Acta Psychiatrica Scandinavica
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