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Acta Psychiatrica Scandinavica

C Okhuijsen-Pfeifer, E A H Huijsman, A Hasan, I E C Sommer, S Leucht, R S Kahn, J J Luykx
OBJECTIVE: No consensus exists on whether clozapine should be prescribed in early stages of psychosis. This systematic review and meta-analysis therefore focus on the use of clozapine as first-line or second-line treatment in non-treatment-resistant patients. METHODS: Articles were eligible if they investigated clozapine compared to another antipsychotic as a first- or second-line treatment in non-treatment-resistant schizophrenia spectrum disorders (SCZ) patients and provided data on treatment response...
September 14, 2018: Acta Psychiatrica Scandinavica
N Berry, R Emsley, F Lobban, S Bucci
OBJECTIVE: An evidence-base is emerging indicating detrimental and beneficial effects of social media. Little is known about the impact of social media use on people who experience psychosis. METHOD: Forty-four participants with and without psychosis completed 1084 assessments of social media use, perceived social rank, mood, self-esteem and paranoia over a 6-day period using an experience sampling method (ESM). RESULTS: Social media use predicted low mood, but did not predict self-esteem and paranoia...
September 10, 2018: Acta Psychiatrica Scandinavica
K Kubo, W W Fleischhacker, T Suzuki, N Yasui-Furukori, M Mimura, H Uchida
OBJECTIVE: To examine characteristics of placebo responders and seek optimal criteria of early improvement with placebo for predicting subsequent placebo response in patients with schizophrenia. METHOD: Data of 672 patients with schizophrenia randomized to placebo in nine double-blind antipsychotic trials were analyzed. Multiple logistic regression analyses were conducted to examine associations between placebo response at week 6 (i.e., a ≥ 25% reduction in the Positive and Negative Syndrome Scale [PANSS] score) and gender, age, study locations, baseline PANSS total or Marder 5-Factor scores, and per cent PANSS score reduction at week 1...
September 9, 2018: Acta Psychiatrica Scandinavica
L V Kessing, H C Rytgaard, T A Gerds, M Berk, C T Ekstrøm, P K Andersen
OBJECTIVE: To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population-based registers. METHODS: All persons in Denmark who purchased the exposure medications of interest between 1995 and 2015 and a random sample of 30% of the Danish population was included in the study. Two different outcome measures were included, (i) a diagnosis of depressive disorder at a psychiatric hospital as in-patient or out-patient and (ii) a combined measure of a diagnosis of depression or use of antidepressants...
September 4, 2018: Acta Psychiatrica Scandinavica
M Cloitre, M Shevlin, C R Brewin, J I Bisson, N P Roberts, A Maercker, T Karatzias, P Hyland
OBJECTIVE: The purpose of this study was to finalize the development of the International Trauma Questionnaire (ITQ), a self-report diagnostic measure of post-traumatic stress disorder (PTSD) and complex PTSD (CPTSD), as defined in the 11th version of the International Classification of Diseases (ICD-11). METHOD: The optimal symptom indicators of PTSD and CPTSD were identified by applying item response theory (IRT) analysis to data from a trauma-exposed community sample (n = 1051) and a trauma-exposed clinical sample (n = 247) from the United Kingdom...
September 3, 2018: Acta Psychiatrica Scandinavica
S D Østergaard, L Foldager, O Mors, P Bech, C U Correll
OBJECTIVE: To test the validity and sensitivity of the six-item version (PANSS-6) of the 30-item Positive and Negative Syndrome Scale (PANSS-30) in treatment-resistant schizophrenia (TRS). METHOD: Using data from the clozapine phase (2E) of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study, we investigated the following: (i) The scalability of PANSS-6 and PANSS-30; (ii) The correlation between PANSS-6 and PANSS-30 total scores; (iii) Whether PANSS-6 could identify cross-sectional symptom remission; and (iv) The efficacy of clozapine, olanzapine, risperidone and quetiapine in TRS using the 'speed of change' on PANSS-6 and PANSS-30 (change in total score per week) as outcome measures...
August 30, 2018: Acta Psychiatrica Scandinavica
P S Santangelo, J Koenig, T D Kockler, M Eid, J Holtmann, S Koudela-Hamila, P Parzer, F Resch, M Bohus, M Kaess, U W Ebner-Priemer
OBJECTIVE: Longitudinal and cross-sectional studies suggest that affective instability is inversely related to greater age in borderline personality disorder (BPD). However, existing studies relied on retrospective self-reports of perceived instability. We examined affective instability in everyday life in patients with BPD and healthy controls (HCs) by age in a cross-sectional e-diary study. METHODS: Two hundred and sixty female participants between 14 and 53 years of age (130 patients with BPD and 130 HCs) carried an e-diary over 4 days...
August 26, 2018: Acta Psychiatrica Scandinavica
S D Østergaard, R E Nielsen, O Mors, R W Licht
No abstract text is available yet for this article.
August 24, 2018: Acta Psychiatrica Scandinavica
F Orhan, L Schwieler, H Fatouros-Bergman, A Malmqvist, S Cervenka, K Collste, L Flyckt, L Farde, C M Sellgren, F Piehl, G Engberg, S Erhardt
OBJECTIVE: Accumulating evidence implicates immune activation in the development of schizophrenia. Here, monocyte numbers, monocyte chemoattractant protein-1 (MCP-1) and chitinase-3-like protein 1 (YKL-40) were investigated in plasma and cerebrospinal fluid (CSF) in first-episode psychosis (FEP) patients. METHOD: CSF and blood were sampled from 42 first-episode psychosis (FEP) patients and 22 healthy controls. The levels of YKL-40 and MCP-1 were measured using electrochemiluminescence assay, and blood monocytes were counted using an XN-9000-hematology analyzer...
August 21, 2018: Acta Psychiatrica Scandinavica
M Na Takuathung, N Hanprasertpong, S Teekachunhatean, N Koonrungsesomboon
OBJECTIVE: To determine the impact of CYP1A2 genetic polymorphisms on the pharmacokinetics of CYP1A2-metabolized antipsychotic drugs in humans by means of systematic review and meta-analysis. METHOD: A systematic search was conducted in PubMed and Scopus databases as of June 26, 2018. Studies reporting the pharmacokinetic parameters of CYP1A2-metabolized antipsychotic drugs in individuals who were genotyped for CYP1A2 genetic polymorphisms were retrieved. Pharmacokinetic parameters of individuals who have mutant alleles of a CYP1A2 genetic polymorphism were compared with the wild-type individuals...
August 15, 2018: Acta Psychiatrica Scandinavica
S Amoretti, B Cabrera, C Torrent, G Mezquida, A Lobo, A González-Pinto, M Parellada, I Corripio, E Vieta, E de la Serna, A Butjosa, F Contreras, S Sarró, R Penadés, A M Sánchez-Torres, M Cuesta, M Bernardo
OBJECTIVE: Cognitive reserve (CR) refers to the brain's capacity to cope with pathology in order to minimize the symptoms. CR is associated with different outcomes in severe mental illness. This study aimed to analyze the impact of CR according to the diagnosis of first-episode affective or non-affective psychosis (FEP). METHOD: A total of 247 FEP patients (211 non-affective and 36 affective) and 205 healthy controls were enrolled. To assess CR, common proxies have been integrated (premorbid IQ; education-occupation; leisure activities)...
August 14, 2018: Acta Psychiatrica Scandinavica
I Arican, N Bass, K Neelam, K Wolfe, A McQuillin, G Giaroli
OBJECTIVE: To investigate the frequency of childhood and adult attention deficit hyperactivity disorder (ADHD) symptoms in a cohort of patients with schizophrenia (SCZ). METHODS: A systematic review was conducted to evaluate existing evidence. Two self-report questionnaires were used to investigate adult ADHD and childhood ADHD symptoms in 126 patients with ICD-10 diagnoses of SCZ. RESULTS: Five studies were included in the systematic review, with the prevalence of childhood and adult ADHD in SCZ subjects ranging between 17-57% and 10-47% respectively...
August 13, 2018: Acta Psychiatrica Scandinavica
E Osuch, S Gao, M Wammes, J Théberge, P Willimason, R J Neufeld, Y Du, J Sui, V Calhoun
OBJECTIVE: This study determined the clinical utility of an fMRI classification algorithm predicting medication-class of response in patients with challenging mood diagnoses. METHODS: Ninety-nine 16-27-year-olds underwent resting state fMRI scans in three groups-BD, MDD and healthy controls. A predictive algorithm was trained and cross-validated on the known-diagnosis patients using maximally spatially independent components (ICs), constructing a similarity matrix among subjects, partitioning the matrix in kernel space and optimizing support vector machine classifiers and IC combinations...
August 6, 2018: Acta Psychiatrica Scandinavica
C Hansson, E Joas, E Pålsson, K Hawton, B Runeson, M Landén
OBJECTIVE: Bipolar disorder carries a high risk of suicide. Identification of risk factors is important. The aim of this study was to study risk factors for suicide in a large cohort of men and women with bipolar disorder. METHOD: A prospective cohort study using clinical data from the Swedish National Quality Register for Bipolar Affective Disorder (BipoläR). The outcome variable was suicide captured in the Cause of Death Register between 2004 and 2014. Hazard ratios (HR) were calculated using Cox proportional hazards models...
August 3, 2018: Acta Psychiatrica Scandinavica
L Lorenzo-Luaces
No abstract text is available yet for this article.
July 30, 2018: Acta Psychiatrica Scandinavica
J Obbels, E Verwijk, K Vansteelandt, A Dols, F Bouckaert, S Schouws, M Vandenbulcke, L Emsell, M Stek, P Sienaert
OBJECTIVE: There is ongoing concern about the possible negative impact of ECT on neurocognitive functioning in older patients. In this study, we aimed to characterize the long-term cognitive effects of ECT in patients with late-life depression, using an extensive neuropsychological battery. METHODS: A total of 110 patients aged 55 years and older with unipolar depression, referred for ECT were included. The neuropsychological test battery was assessed prior to ECT and 6 months after the last ECT session...
July 12, 2018: Acta Psychiatrica Scandinavica
A J E Dirkzwager, P Nieuwbeerta
OBJECTIVE: Mental health problems are common in prison populations. Less is known about how mental health problems develop during imprisonment. The objective was to examine the longitudinal course of mental health symptoms during imprisonment and individual factors associated with the development of these symptoms. METHOD: In a prospective cohort study, 1.664 Dutch male prisoners were questioned 3 weeks after their arrival in detention. Those still in custody were questioned again after 3, 9, and 18 months...
July 12, 2018: Acta Psychiatrica Scandinavica
N Warren, D Siskind, C O'Gorman
OBJECTIVE: To review the psychiatric symptoms of anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, in an attempt to differentiate the presentation from a primary psychiatric disorder. METHOD: A systematic literature review of PubMed and EMBASE of all published cases of anti-NMDA receptor encephalitis was performed from inception to January 2018. RESULTS: There were 706 cases of anti-NMDA receptor encephalitis identified. Cases were typically young (mean age 22...
July 10, 2018: Acta Psychiatrica Scandinavica
P Bucci, S Galderisi, A Mucci, A Rossi, P Rocca, A Bertolino, E Aguglia, M Amore, I Andriola, A Bellomo, M Biondi, A Cuomo, L dell'Osso, A Favaro, F Gambi, G M Giordano, P Girardi, C Marchesi, P Monteleone, C Montemagni, C Niolu, L Oldani, F Pacitti, F Pinna, R Roncone, A Vita, P Zeppegno, M Maj
OBJECTIVE: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. METHOD: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored...
July 8, 2018: Acta Psychiatrica Scandinavica
P S Ritter, J Schwabedal, M Brandt, W Schrempf, F Brezan, A Krupka, C Sauer, A Pfennig, M Bauer, B Soltmann, E Nikitin
OBJECTIVE: Bipolar disorder is a severe mental disorder for which currently no reliable biomarkers exist. It has been shown that patients with schizophrenia but not with unipolar depression have a reduced density of fast sleep spindles during N2 sleep. The aim of this study was to assess fast sleep spindle density in euthymic patients with bipolar disorder. METHODS: Patients with bipolar disorder (n = 24) and healthy control subjects (n = 25) were assessed using all-night polysomnography...
July 4, 2018: Acta Psychiatrica Scandinavica
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