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Acta Oto-laryngologica

Henryk Skarzynski, Artur Lorens, Marika Kruszynska, Anita Obrycka, Dorota Pastuszak, Piotr Henryk Skarzynski
CONCLUSION: Cochlear implants improve the hearing abilities of individuals with unilateral hearing loss and no tinnitus. The benefit is no different from that seen in patients with unilateral hearing loss and incapacitating tinnitus. OBJECTIVE: To evaluate hearing outcomes after cochlear implantation in individuals with unilateral hearing loss and no tinnitus and compare them to those obtained in a similar group who had incapacitating tinnitus. METHODS: Six cases who did not experience tinnitus before operation and 15 subjects with pre-operative tinnitus were evaluated with a structured interview, a monosyllabic word test under difficult listening situations, a sound localization test, and an APHAB (abbreviated profile of hearing aid benefit) questionnaire...
January 18, 2017: Acta Oto-laryngologica
Shengcai Wang, Jie Zhang, Wentong Ge, Yuanhu Liu, Yongli Guo, Yue Liu, Ning Wang, Yuzhu He, Jun Tai, Xin Ni
CONCLUSIONS: Low dose oral sildenafil citrate tablets are safe and effective to decrease the lesions volume in some LMs children, especially with macrocystic lesion or mixed type. OBJECTIVE: To evaluate the efficacy and safety of oral sildenafil in treatment of pediatric head and neck lymphatic malformations (LMs). SUBJECTS AND METHODS: In this open-label study, 21 children diagnosed with LMs were given oral sildenafil and stopped at week 24...
January 17, 2017: Acta Oto-laryngologica
Yang Xu, Wei Ping Yang, Bo Hua Hu, Shiming Yang, Donald Henderson
CONCLUSION: p53 and Bcl-2 (B-cell lymphoma 2) are involved in the process of sensory cell degeneration in aging cochleae. OBJECTIVE: To determine molecular players in age-related hair cell degeneration, this study examined the changes in p53 and Bcl-2 expression at different stages of apoptotic and necrotic death of hair cells in aging rat cochleae. METHODS: Young (3-4 months) and aging (23-24 months) Fisher 344/NHsd rats were used. The thresholds of the auditory brainstem response (ABR) were measured to determine the auditory function...
January 17, 2017: Acta Oto-laryngologica
Hiroshi Yoshida, Shigeyuki Murono, Takayoshi Ueno, Yosuke Nakanishi, Akira Tsuji, Miyako Hatano, Kazuhira Endo, Satoru Kondo, Hisashi Sugimoto, Naohiro Wakisaka, Tomokazu Yoshizaki
CONCLUSION: The detection of human papillomavirus (HPV)-DNA in oral rinse with auto-nested GP5+/GP6 + PCR is useful as a biomarker of oropharyngeal cancer. BACKGROUND: This study aimed to determine the usefulness of oral rinse to detect HPV-DNA as a biomarker of HPV-positive oropharyngeal cancer (OPC). PATIENTS AND METHODS: One hundred and ten patients with various head and neck diseases, including 19 patients with OPC, were enrolled. Oral rinse and tonsillar swab were collected, and auto-nested GP5+/GP6 + PCR for HPV-DNA was performed...
January 17, 2017: Acta Oto-laryngologica
Jorge Otero-Millan, Carolina Treviño, Ariel Winnick, David S Zee, John P Carey, Amir Kheradmand
CONCLUSION: vOCR can detect loss of otolith-ocular function without specifying the side of vestibular loss. Since vOCR is measured with a simple head tilt maneuver, it can be potentially used as a bedside clinical test in combination with video head impulse test. OBJECTIVE: Video-oculography (VOG) goggles are being integrated into the bedside assessment of patients with vestibular disorders. Lacking, however, is a method to evaluate otolith function. This study validated a VOG test for loss of otolith function...
January 13, 2017: Acta Oto-laryngologica
Xiao-Kai Yang, Yan-Yan Zheng, Xiao-Guo Yang
CONCLUSION: To make a comprehensive analysis with a variety of diagnostic maneuvers is conducive to the correct diagnosis and classification of BPPV. OBJECTIVE: Based on the standard spatial coordinate-based semicircular canal model for theoretical observation on diagnostic maneuvers for benign paroxysmal positional vertigo (BPPV) to analyze the meaning and key point of each step of the maneuver. MATERIALS AND METHODS: This study started by building a standard model of semicircular canal with space orientation by segmentation of the inner ear done with the 3D Slicer software based on MRI scans, then gives a demonstration and observation of BPPV diagnostic maneuvers by using the model...
January 13, 2017: Acta Oto-laryngologica
Mosaad Abdel-Aziz, Noha Azab, Hisham Lasheen, Nader Naguib, Ramez Reda
CONCLUSION: Diffuse idiopathic skeletal hyperostosis (DISH) is a cause of swallowing disorders in elderly, and otolaryngologists should be aware of the disease on dealing with old patients complaining of dysphagia. The condition may be treated conservatively in most patients; however, surgical reduction of cervical osteophytes may be needed in severe cases. OBJECTIVE: Large cervical osteophytes may cause dysphagia; they compress the pharynx leading to mechanical impairment of swallowing...
January 13, 2017: Acta Oto-laryngologica
Lijuan Li, Ting Xu, Yu Song, Yan Yan, Furong Ma, Li Wang
CONCLUSION: Airtraq(®) laryngoscope can obviously improve laryngeal visualization and may provide a useful solution to treatment of patients with difficult laryngeal exposure (DLE) under a conventional suspension laryngoscope in phonomicrosurgery. OBJECTIVE: In phonomicrosurgery, otolaryngologists may inevitably encounter DLE. Attempts to improve laryngeal exposure have yielded important advances, but the prevalence of DLE yet remains persistent. To overcome this problem, this study applied the Airtraq(®) laryngoscope to perform phonomicrosurgery combined with a video system...
January 13, 2017: Acta Oto-laryngologica
Hidenori Tanaka, Yukinori Takenaka, Susumu Nakahara, Atshushi Hanamoto, Takahito Fukusumi, Takahiro Michiba, Norihiko Takemoto, Hironori Cho, Masashi Yamamoto, Yoshifumi Yamamoto, Hidenori Inohara
CONCLUSION: The age-adjusted Charlson comorbidity index (ACCI) was associated with overall survival, disease-specific survival, and non-cancer death in patients treated with chemoradiation therapy (CRT) for hypopharyngeal cancer (HPC). Further studies using other CRT regimens are required. OBJECTIVE: To investigate the impact of the ACCI on survival in patients with HPC. METHODS: This study reviewed 128 patients with HPC who received CRT between 2004-2012...
January 13, 2017: Acta Oto-laryngologica
Kubra Topal, Bulent Aktan, Muhammed Sedat Sakat, Korhan Kilic, Mustafa Sitki Gozeler
CONCLUSION: Tramadol was found to be more effective than dexamethasone in post-operative pain control, with long-lasting relief of pain. OBJECTIVE: This study aimed to compare the effects of pre-operative local injections of tramadol and dexamethasone on post-operative pain, nausea and vomiting in patients who underwent tonsillectomy. DESIGN: Sixty patients between 3-13 years of age who were planned for tonsillectomy were included in the study...
January 13, 2017: Acta Oto-laryngologica
Jing Zhang, Ying Wang, Yumei Duan, Dan Fan, Zhijiao Zhou, Jianghai Huang, Rui Wei, Liangfang Shen
CONCLUSION: In patients with nasopharyngeal carcinoma (NPC), PKCα is linked to local advancement and plays dual roles in tumorigenesis. Moreover, positive PKCα is associated with 2-year overall survival of NPC. OBJECTIVE: This study seeks to investigate the role of PKCα to identify different sub-types in NPC. METHODS: PKCα expression levels were detected in a collection of NPC samples. CT and MRI scans of the corresponding patients were used to assess adjacent tissue invasion and lymph node metastasis...
January 13, 2017: Acta Oto-laryngologica
(no author information available yet)
No abstract text is available yet for this article.
January 13, 2017: Acta Oto-laryngologica
Jukka Ylikoski, Jarmo Lehtimäki, Ulla Pirvola, Antti Mäkitie, Antti Aarnisalo, Petteri Hyvärinen, Matti Ylikoski
CONCLUSION: Transcutaneous vagal nerve stimulation (tVNS) might offer a targeted, patient-friendly, and low-cost therapeutic tool for tinnitus patients with sympathovagal imbalance. OBJECTIVES: Conventionally, VNS has been performed to treat severe epilepsy and depression with an electrode implanted to the cervical trunk of vagus nerve. This study investigated the acute effects of tVNS on autonomic nervous system (ANS) imbalance, which often occurs in patients with tinnitus-triggered stress...
January 13, 2017: Acta Oto-laryngologica
(no author information available yet)
No abstract text is available yet for this article.
January 13, 2017: Acta Oto-laryngologica
Andreas Knopf, Nikolaus Cortolezis, Murat Bas, Naglaa Mansour, Benedikt Hofauer
CONCLUSION: The multimodal diagnostic algorithm is a simple diagnostic tool in the pre-operative assessment of submandibular masses that enables one-stage surgical concepts. BACKGROUND: The pre-operative assessment of submandibular masses is of major clinical impact. This study assesses the diagnostic utility of a newly introduced diagnostic algorithm in the differentiation of submandibular masses based on epidemiological and B-mode ultrasonographic data. METHODS: One hundred and eighty-eight patients with submandibular triangle masses were included...
January 13, 2017: Acta Oto-laryngologica
Wei Chen, Haijin Yi, Liang Zhang, Fei Ji, Shuolong Yuan, Yue Zhang, Lili Ren, Jianan Li, Lei Chen, Weiwei Guo, Shiming Yang
CONCLUSIONS: In this investigation, a large mammal, Rongchang pigs were used to successfully establish a research platform for cochlear implant study on the routine use of it in clinic. OBJECTIVE: The aim of this study was to establish a standard method of cochlear implant in a large mammal-pig. METHODS: Rongchang pigs were selected, then divided into two groups: normal-hearing group (Mitf +/+) and mutation group with hearing loss (Mitf -/-)...
January 12, 2017: Acta Oto-laryngologica
Marie Lundberg, Pia Nikander, Katja Tuomainen, Helena Orell-Kotikangas, Antti Mäkitie
CONCLUSION: Finnish head and neck cancer (HNC) patients show signs of severe malnutrition already at presentation, measured by bioelectric impedance analysis (BIA). BIA may be a practical method to detect malnutrition, analyze body composition, and to identify high-risk patients in this population. OBJECTIVES: BIA is a validated method for evaluating body composition and detecting malnutrition. Low phase angle (PA) is associated with increased mortality and morbidity...
January 12, 2017: Acta Oto-laryngologica
Haijin Yi, Bin Hu, Guoping Yin, Xin Li, Jinkun Xu, Jingying Ye, Shi-Ming Yang
CONCLUSION: Unusual primary tumors of the facial nerve should be considered in patients with progressive facial paralysis, especially if this is accompanied by hearing loss or vertigo. Misdiagnosis could increase the difficulties of operation, diminish the chance of facial nerve reconstruction, and increase the likelihood of poor reconstructive outcomes. OBJECTIVE: This paper was to determine the characteristics of facial nerve primary tumors misdiagnosed as tumor-free conditions many years prior, and to describe appropriate treatments...
January 12, 2017: Acta Oto-laryngologica
Anna Julkunen, Emma Terna, Jura Numminen, Antti Markkola, Prasun Dastidar, Matti Karjalainen, Heini Huhtala, Markus Rautiainen, Jukka Meurman, Sanna Toppila-Salmi
CONCLUSION: The study demonstrated considerable inter-observer variation in certain surgically important structures. This would indicate the significance for consultation when evaluating sinus CT scans of CRS patients for planned advanced sinus surgery. OBJECTIVES: After the failure of medical treatment of chronic rhinosinusitis (CRS), the need for surgery and the pre-operative planning of safe surgery is based on computed tomography (CT) findings. The aim of this prospective study was to compare inter-observer agreement of anatomical and surgical structures of sinus CT scans...
December 16, 2016: Acta Oto-laryngologica
Naomi Kudo, Atsushi Matsubara, Hisanori Nishizawa, Tomoya Miura
BACKGROUND: The most crucial clinical problem of Eosinophilic Otitis Media (EOM) is sensorineural hearing loss. A previous report revealed that repeated antigen stimulation of middle ear causes eosinophilic inflammation not only in the middle ear but also in the inner ear. OBJECTIVE: The purpose of the present study was to elucidate the mechanism of eosinophil infiltration to the inner ear in the animal model of EOM. METHODS: Continuous OVA stimulation to the middle ear of guinea pigs was performed for 7 days, 14 days, and 28 days...
December 16, 2016: Acta Oto-laryngologica
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