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Acta Oto-laryngologica

Zhi-Jian Zhang, Hong-Xia Guan, Kun Yang, Bo-Kui Xiao, Hua Liao, Yang Jiang, Tao Zhou, Qing-Quan Hua
CONCLUSION: The auditory brainstem response (ABR) wave I threshold, latency and amplitude are insensitive to spiral ganglion neurons (SGNs) degeneration, but are sensitive to the degeneration of Schwann cells and can estimate the status of Schwann cells in a neural degeneration mouse model. The thorough pre-operative ABR assessment would be helpful in predicting cochlear implant performance. OBJECTIVES: This study aimed in finding a non-invasive electrophysiological method to evaluate the status of the auditory nerve and the Schwann cells in sensorineural hearing loss (SNHL) and auditory neuropathy (AN) ears, and providing useful information for candidates screening and outcome prediction in cochlear implantation...
March 19, 2018: Acta Oto-laryngologica
Ulrich Hoppe, Thomas Hocke, Frank Digeser
OBJECTIVE: To determine speech perception in quiet and noise of adult cochlear implant listeners retaining a hearing aid contralaterally. Second, to investigate the influence of contralateral hearing thresholds and speech perception on bimodal hearing. PATIENTS AND METHODS: Sentence recognition with hearing aid alone, cochlear implant alone and bimodally at 6 months after cochlear implantation were assessed in 148 postlingually deafened adults. Data were analyzed for bimodal summation using measures of speech perception in quiet and in noise...
March 19, 2018: Acta Oto-laryngologica
Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Michihiro Nakada, Takuma Makino, Yasutoshi Komatsubara, Yuko Matsuyama, Yuto Naoi, Kazunori Nishizaki
OBJECTIVES: We reviewed surgical results of canal wall-down tympanoplasty (CWDT) with soft posterior meatal wall reconstruction (SWR) for acquired cholesteatoma (AC), and identified factors associated with surgical outcomes. METHODS: Results from 119 ears with AC (pars flaccida, n = 99; pars tensa, n = 20) that underwent CWDT with SWR were retrospectively reviewed. We defined postoperative balloon-like retraction (PBR) with web formation, which needed reoperation to clean accumulated cerumen, as postoperative deep retraction pocket (PDRP)...
March 8, 2018: Acta Oto-laryngologica
Hideaki Moteki, Yuichi Isaka, Yuji Inaba, Mitsuo Motobayashi, Shin-Ya Nishio, Satoshi Ohira, Takuya Yano, Satoshi Iwasaki, Tanri Shiozawa, Kenichi Koike, Shin-Ichi Usami
OBJECTIVE: Congenital cytomegalovirus (cCMV) infection is the most common congenital infection, with the majority of infected newborns having no detectable signs. The aim of this study was to examine the accuracy of our newly developed DBS-based assay as an appropriate mass screening method for cCMV infection. METHODS: Between May 2011 and October 2016, newborns delivered at six hospitals in Nagano Prefecture, Japan were enrolled prospectively. We employed dried blood spot (DBS)-based assays with real-time quantitative PCR (qPCR)...
March 7, 2018: Acta Oto-laryngologica
Yue Yang, Benqing Zhou, Jian Zhou, Xiangyang Shi, Yan Sha, Haitao Wu
OBJECTIVE: To evaluate the capability of indirect computed tomography and magnetic resonance lymphography (CT/MR-LG) with gadolinium-loaded, polyethylenimine-entrapped gold nanoprobes (Gd-Au PENPs) for assessing lingual sentinel lymph node (SLN) metastasis in a tongue VX2 carcinoma model. MATERIALS AND METHODS: Seventeen rabbits were used to establish a metastatic cervical lymph node model by implanting VX2 carcinoma suspension into the ventral tongue muscle. CT and MR images were acquired one hour after Gd-Au PENPs injection into the tongue submucosa bilaterally, on 1w (n = 4), 2w (n = 6) and 3w (n = 7) tumour-bearing rabbits after carcinoma transplantation...
March 7, 2018: Acta Oto-laryngologica
Hasan Demirhan, Ali Rıza Gökduman, Bahtiyar Hamit, Müge Fethiye Yürekli Altındağ, Özgür Yiğit
OBJECTIVE: The primary objective is to investigate the contribution of intratympanic steroids in the primary treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). The secondary objective is to compare methylprednisolone (MP) and dexamethasone in terms of their effectiveness and injection-site pain. METHODS: Two hundred and four patients with ISSNHL, 144 patients underwent systemic steroid therapy (SST) alone and 60 patients underwent combined therapy (CT)...
March 7, 2018: Acta Oto-laryngologica
Joshua A Tillinger, Chhavi Gupta, Kadri Ila, Jamal Ahmed, Jeenu Mittal, Thomas R Van De Water, Adrien A Eshraghi
OBJECTIVE: The present study is aimed at determining the efficacy and exploring the mechanisms by which l-N-acetylcysteine (l-NAC) provides protection against tumor necrosis factor-alpha (TNFα)-induced oxidative stress damage and hair cell loss in 3-day-old rat organ of Corti (OC) explants. Previous work has demonstrated a high level of oxidative stress in TNFα-challenged OC explants. TNFα can potentially play a significant role in hair cell loss following an insult to the inner ear...
March 7, 2018: Acta Oto-laryngologica
Elisabeth Mamelle, Naila El Kechai, Victor Adenis, Yann Nguyen, Olivier Sterkers, Florence Agnely, Amélie Bochot, Jean Marc Edeline, Evelyne Ferrary
OBJECTIVES: Intratympanic injection of corticosteroids membrane after noise-induced hearing loss is an accepted alternative to general administration. We investigated the effect on hearing of a hyaluronic acid gel with liposomes loaded with dexamethasone (DexP) administered into the middle ear. METHODS: An acute acoustic trauma was performed to 13 guinea pigs for a period of 1 h on Day -2. Two 2 days after the noise trauma, the animals were then assigned randomly to four experimental groups: control without gel, gel injection, gel-containing free DexP, gel-containing DexP loaded into liposomes...
March 5, 2018: Acta Oto-laryngologica
Lei Jin, Keyong Li, Xiaoyan Li
OBJECTIVE: To investigate the diagnostic value of distortion product otoacoustic emission (DPOAE) together with tympanometry in assessing otitis media with effusion in children. METHODS: Three hundred and thirty-nine patients, who were diagnosed with obstructive sleep apnea-hypopnea syndrome (OSAHS) and prepared to undergo adenotonsillectomy and had a unilateral or bilateral type 'B' or 'C' tympanogram were enrolled in this study. Patients were divided into the following four groups: Group 1, type 'B' tympanogram with positive DPOAE; Group 2, type 'B' tympanogram with negative DPOAE; Group 3, type 'C' tympanogram with positive DPOAE and Group 4, type 'C' tympanogram with negative DPOAE...
March 5, 2018: Acta Oto-laryngologica
Changjiang Li, Na Zhang, Shuyi Wang, Lei Cheng, Haitao Wu, Jian Chen, Min Chen, Fang Shi
OBJECTIVE: To provide a reference for classification and treatment of vocal cords leukoplakia. METHODS: 640 cases of patients with vocal cords leukoplakia were divided into three groups based on the appearances. There were respectively 81 smooth flat lesions, 155 smooth hypertrophy lesions and 13 rough lesions were treated with conservative methods and 26, 153 and 212 cases were resected surgically for biopsy. RESULTS: A majority of smooth flat leukoplakia lesions were cured by non-operational methods and no atypical hyperplasia...
March 5, 2018: Acta Oto-laryngologica
Shuo Ding, Junwei Huang, Zhigang Huang, Hongbo Xu, Wei Guo, Yang Zhang
BACKGROUND: The lack of standardized treatment is problematic in laser surgery for laryngeal cancer, and may result in an increased recurrence rate. This study analyzed the prognosis of early laryngeal carcinoma after different types of cordectomy with laser surgery. METHODS: A cohort of 818 patients with stage Tis or T1 primary early glottic squamous cell carcinoma treated with CO2 laser surgery was retrospectively analyzed. RESULTS: Of the 818 patients, According to the Kaplan-Meier method, the rate of 5-year overall survival was 92...
March 5, 2018: Acta Oto-laryngologica
Qingsong Liu, Guodong Feng, Yingying Shang, Cheng Chi, Yufei Qiao, Zhiqiang Gao
OBJECTIVE: The objective of this study is to establish a reliable intraoperative auditory threshold monitoring system for ossiculoplasty surgery. DESIGN: The chirp signal of self-designed sound field earphone (SFE) was calibrated physically and psychophysically. The interaural attenuation of the SFE was tested in patients with unilateral complete deafness and contralateral normal hearing (10 patients). Self-designed SFEs were used to measure the chirp-evoked auditory steady-state responses (Chirp-ASSR) threshold of patients (14 cases and 15 ears) with conductive hearing loss after anesthesia but before surgery...
March 5, 2018: Acta Oto-laryngologica
Peng Tian, Fan Wu, Jingyi Wang, Huashuang Ou, Xiang Liu, Qiujian Chen, Hua Dang, Yiqing Zheng, Xianghong Zhang, Hua Zou
CONCLUSION: An intralesional bleomycin A5 (BLE) injection might be used as an alternative therapy for eosinophilic-type nasal polyps (NPs). BLE-induced apoptosis might play an important role in shrinkage of NPs. OBJECTIVES: The aim of this study is to determine the effect and explore the possible role of apoptosis in shrinkage of NPs. METHODS: Twenty-nine patients with eosinophilic-type NPs experienced repeated local injection of BLE. The recurrence rate of this group was obtained...
February 28, 2018: Acta Oto-laryngologica
Jan Peter Thomas, Konstantin van Ackeren, Stefan Dazert, Ingo Todt, Andreas Prescher, Christiane Voelter
OBJECTIVES: To compare the feasibility of transmastoid implantation of an active transcutaneous bone conduction device (BCD) in the most important pathologies of the temporal bone and the impact of implant lifts in adulthood. METHODS: First, clinical predominant pathologies for implantation of this BCD were evaluated by a literature review. Then, high-resolution CT of 240 temporal bones with neuro-otologic diseases (NOD), chronic otitis media (COM), or cholesteatoma, respectively, were investigated regarding their implantability, using a radiological simulation program...
February 23, 2018: Acta Oto-laryngologica
Meixiang Chen, Chenjie Hou, Ting Chen, Zhihui Lin, Xin Wang, Yanling Zeng
BACKGROUND: The primary goal of this study was to investigating the symptoms, in addition to the reflux-related laryngopharynx inflammation performance of asymptomatic, volunteers, and verified the 'normal point'. METHODS: A total of 91 asymptomatic subjects were recruited for this cross-sectional study between March 2016 and September 2016. Participants completed the reflux symptom index (RSI) assessment and underwent laryngostroboscopic examination using a rigid endoscope...
February 22, 2018: Acta Oto-laryngologica
Riina Niemensivu, Risto Paavo Roine, Harri Sintonen, Erna Kentala
OBJECTIVE: To evaluate health-related quality of life (HRQoL) in hearing-impaired adolescents and children and to compare it with that of hearing individuals. STUDY DESIGN AND SETTING: Hearing-impaired adolescents and children were recruited to the study during their annual control visit to the Hearing Clinic of Helsinki University Hospital. They filled in a HRQoL questionnaire, either the 16-dimensional 16D (adolescents aged 12-17 years) or the 17-dimensional 17D (children aged 7-11 years)...
February 22, 2018: Acta Oto-laryngologica
Hiroshi Doi, Kenji Uemoto, Norihisa Masai, Daisaku Tatsumi, Hiroya Shiomi, Ryoong-Jin Oh
PURPOSE: To analyze the outcomes following re-irradiation for local recurrence of rare head and neck tumors. MATERIAL AND METHODS: We retrospectively analyzed 11 patients who had received intensity-modulated radiation therapy (IMRT) for recurrent tumors in the head and neck except for laryngopharynx. RESULTS: Primary tumor sites included the maxillary sinus, nasal cavity, and external ear canal in six, three, and two patients, respectively...
February 22, 2018: Acta Oto-laryngologica
Juuso Pellinen, Juha-Pekka Vasama, Ilkka Kivekäs
OBJECTIVES: To evaluate long-term benefits of atresiaplasty on hearing and the impact of surgery on quality of life (QoL) in congenital aural atresia (CAA) patients. METHODS: We evaluated the long-term hearing results, the impact of atresiaplasty on QoL, the meatal diameter of the operated ear canal, and the cumulative number of post-operative hospital visits in 14 CAA patients, on average, 12 years (range: 4-17 years) post-operatively. RESULTS: The mean preoperative pure tone average (PTA) was 61 dB HL...
February 9, 2018: Acta Oto-laryngologica
Lina Li, Hu Yuan, Hongyang Wang, Jing Guan, Lan Lan, Dayong Wang, Liang Zong, Qiong Liu, Bing Han, Deliang Huang, Qiuju Wang
BACKGROUND: The molecular and genetic research showed the association between DFNA11 and mutations in MYO7A. This research aimed to identify a MYO7A mutation in a family with nonsyndromic autosomal dominant hearing loss. METHODS: We have ascertained one large multigenerational Chinese family (Z029) with autosomal dominant late-onset progressive non-syndromic sensorineural hearing loss. Genome-wide linkage analysis of the family mapped the disease locus to the DFNA11 interval, where the MYO7A was considered as a candidate gene...
February 5, 2018: Acta Oto-laryngologica
Peggy R Trueblood, Monica Rivera, Christian Lopez, Carolyn Bentley, Nancy Wubenhorst
BACKGROUND: Computerized dynamic posturography (CDP) is the gold standard to differentiate between sensory, motor, and central adaptive impairments to postural control. OBJECTIVE: To obtain normative values in healthy adults age 20-69 for a CDP system that uses a full-field dynamic visual surround. This is in contrast to the mechanically movable visual surround used in traditional CDP systems. METHODS: Fifty healthy adults divided into five age groups were tested during the three test protocols for CDP: sensory organization test (SOT), motor control test (MCT), and adaptation test (ADT)...
February 1, 2018: Acta Oto-laryngologica
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