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Acta Oto-laryngologica

Marco Caversaccio, Kate Gavaghan, Wilhelm Wimmer, Tom Williamson, Juan Ansò, Georgios Mantokoudis, Nicolas Gerber, Christoph Rathgeb, Arne Feldmann, Franca Wagner, Olivier Scheidegger, Martin Kompis, Christian Weisstanner, Masoud Zoka-Assadi, Kai Roesler, Lukas Anschuetz, Markus Huth, Stefan Weber
CONCLUSION: A system for robotic cochlear implantation (rCI) has been developed and a corresponding surgical workflow has been described. The clinical feasibility was demonstrated through the conduction of a safe and effective rCI procedure. OBJECTIVES: To define a clinical workflow for rCI and demonstrate its feasibility, safety, and effectiveness within a clinical setting. METHOD: A clinical workflow for use of a previously described image guided surgical robot system for rCI was developed...
February 1, 2017: Acta Oto-laryngologica
Pieter D de Veij Mestdagh, David R Colnot, Pepijn A Borggreven, Claudia C Orelio, Jasper J Quak
CONCLUSION: Evaluation of the follow-up of 67 patients shows that S53P4 bioactive glass (BAG) granules are safe and effective as obliteration material in cholesteatoma surgery. OBJECTIVES: To investigate the safety and efficacy of mastoid obliteration using S53P4 BAG in cholesteatoma surgery. Clinical outcomes were infection control (Merchant's grading), cholesteatoma recidivism, and audiometric performance. METHODS: Retrospective follow-up study at the Diakonessenhuis, Utrecht, the Netherlands...
January 26, 2017: Acta Oto-laryngologica
Meng Lian, Qian Shi, Jugao Fang, Ling Feng, Hongzhi Ma, Haizhou Wang, Liang Zhang, Hong Wang, Zhihong Ma, Honggang Liu
CONCLUSION: These results provided a battery of genes relating to TPF chemotherapeutic sensitivity and might act as molecular targets in laryngeal squamous cell carcinoma (LSCC) treatment. Moreover, these candidate biomarkers could contribute to LSCC individualized treatment. OBJECTIVES: To screen out a set of candidate genes which could help to determine whether patients with LSCC could benefit from TPF induction chemotherapy. METHOD: Gene-expression profiles in seven TPF-sensitive patients were compared to four resistant controls by microarray analysis...
January 26, 2017: Acta Oto-laryngologica
Kenichi Takano, Nozomi Takahashi, Noriko Ogasawara, Takatoshi Yotsuyanagi, Tetsuo Himi
CONCLUSION: This is the first report to investigate the correlation between ear anomalies related to the development of specific ear structures and chorda tympani dysfunction (CTD) in congenital microtia. CTD is not always consistent with the severity of the ear anomaly or the presence of facial nerve paralysis (FNP). OBJECTIVES: To investigate the relationship between the severity of ear anomalies and CTD as well as FNP in congenital microtia. METHODS: A retrospective assessment was performed for all patients with microtia over the period 2010-2016...
January 26, 2017: Acta Oto-laryngologica
Stine A Schrøder, Allan Bardow, Steffen Eickhardt-Dalbøge, Helle K Johansen, Preben Homøe
CONCLUSION: The present study indicates that parotid saliva is sterile on entry to the oral cavity. OBJECTIVES: The objective was to investigate if parotid saliva is sterile on entry to the oral cavity and, thus, prior to contamination by oral bacteria. METHOD: Forty healthy volunteers were included in sterile parotid saliva collection. Parotid saliva was collected using a sterile Lashley cup, placed over the papilla of the Stensen´s duct, as well as sterile tubes and syringes for collection...
January 26, 2017: Acta Oto-laryngologica
Lei Zhou, Miaolin Feng, Xinsheng Huang, Maoli Duan
CONCLUSION: A tentative conclusion was made that the finite element method can be used to investigate the fatigue life of the tympanic membrane after ossiculoplasty; the main reason of the extrusion of the tympanic membrane may not be blamed to the fatigue mechanism under normal sound pressure. OBJECTIVE: This study was to investigate the extrusion of the prosthesis from the tympanic membrane at post-ossiculoplasty by finite element method. METHODS: A finite element model of the human middle ear has been constructed and used as the model of the constructed middle ear at post-ossiculoplasty...
January 26, 2017: Acta Oto-laryngologica
Young-Soo Chang, Kang Hyun Bang, Byoungseo Jeong, Gang-Gyu Lee
CONCLUSION: This study evaluated the efficacy of concurrent administration of ITSI and systemic steroids in delayed treatment of NIHL after gunshot noise exposure. The results showed additional hearing benefits with administration of ITSI. Further evaluation is warranted to confirm this efficacy. OBJECTIVE: This investigation evaluated the effects of early administration of an intratympanic steroid injection (ITSI) in combination with systemic steroids treatment in patients with acoustic trauma caused by gunshot noise...
January 26, 2017: Acta Oto-laryngologica
Helena Orell-Kotikangas, Pia Österlund, Outi Mäkitie, Kauko Saarilahti, Paula Ravasco, Ursula Schwab, Antti A Mäkitie
CONCLUSIONS: One third of the patients had cachexia with an association of significantly shorter survival. These results suggest that combining HGS and MAMA seems to be a practical method to screen cachexia in patients with head and neck cancer and may also be used when assessing their prognosis. OBJECTIVES: The aim of this study was to analyze the hypothesis that cachexia defined as both low mid-arm muscle area (MAMA) and handgrip strength (HGS) is associated with decreased survival in patients with head and neck squamous cell carcinoma (HNSCC)...
January 26, 2017: Acta Oto-laryngologica
Mingjie Wang, Bing Zhou, Shunjiu Cui, Yunchuan Li
CONCLUSION: The endoscopic transnasal approach with IGS is a safe and effective technique, allowing completely resection of JPOF, with minimal morbidity and recurrence. OBJECTIVES: JPOF is a benign but locally aggressive fibro-osseous lesion. This study presents a series of JPOF cases, involving anterior skull base and orbit, treated by endoscopic transnasal approach with image guidance system (IGS) to resect the mass completely. METHOD: This study retrospectively reviewed the clinical presentations, surgical procedures, and complications of 11 patients with JPOF who were treated by endoscopic approach from May 2009 to April 2014...
January 26, 2017: Acta Oto-laryngologica
Hidemi Miyazaki, Yasuyuki Nomura, Ali Mardassi, Arnaud Deveze, Masahiro Miura, Maki Jike, Jacques Magnan
CONCLUSION: Patients with incapacitating Meniere Disease (MD) suffer in their daily lives and activities because of the dizziness and anxiety induced by MD. Minimally Invasive Vestibular Neurotomy (MIVN) is a safe and effective surgical treatment for these individuals, and improved their dizziness and anxiety. OBJECTIVES: This study aimed to assess the state of dizziness and anxiety of patients with incapacitating MD and its improvement through MIVN. METHOD: A total of 118 patients with incapacitating MD who underwent MIVN in France and Japan were evaluated...
January 26, 2017: Acta Oto-laryngologica
Ping Ye, Qian Huang, Bing Zhou
CONCLUSION: The key technical challenges in the resection of OFs are rapid removal of tumors by image-guided navigation, determining the boundary of the resection and the proper control of blood supply through the anterior or posterior ethmoidal arteries. OBJECTIVE: This study aimed to analyze the clinical data of adult patients with paranasal ossifying fibromas involving the anterior skull base and orbit. The surgical technique and indications are also discussed...
January 26, 2017: Acta Oto-laryngologica
Jungirl Seok, Ye Ji Shim, Chae-Seo Rhee, Jeong-Whun Kim
CONCLUSION: Olfactory test scores are significantly correlated with self-rated severity scales. However, the statistical rating based on olfactory tests did not strongly agree with the self-reported severity rating. This suggests that there is a discrepancy between olfactory test results and the severity described by patients themselves. OBJECTIVES: This study aimed to identify the correlation between statistical ratings based on test scores and self-rating of the severity of olfactory loss...
January 23, 2017: Acta Oto-laryngologica
Henryk Skarzynski, Artur Lorens, Marika Kruszynska, Anita Obrycka, Dorota Pastuszak, Piotr Henryk Skarzynski
CONCLUSION: Cochlear implants improve the hearing abilities of individuals with unilateral hearing loss and no tinnitus. The benefit is no different from that seen in patients with unilateral hearing loss and incapacitating tinnitus. OBJECTIVE: To evaluate hearing outcomes after cochlear implantation in individuals with unilateral hearing loss and no tinnitus and compare them to those obtained in a similar group who had incapacitating tinnitus. METHODS: Six cases who did not experience tinnitus before operation and 15 subjects with pre-operative tinnitus were evaluated with a structured interview, a monosyllabic word test under difficult listening situations, a sound localization test, and an APHAB (abbreviated profile of hearing aid benefit) questionnaire...
January 18, 2017: Acta Oto-laryngologica
Shengcai Wang, Jie Zhang, Wentong Ge, Yuanhu Liu, Yongli Guo, Yue Liu, Ning Wang, Yuzhu He, Jun Tai, Xin Ni
CONCLUSIONS: Low dose oral sildenafil citrate tablets are safe and effective to decrease the lesions volume in some LMs children, especially with macrocystic lesion or mixed type. OBJECTIVE: To evaluate the efficacy and safety of oral sildenafil in treatment of pediatric head and neck lymphatic malformations (LMs). SUBJECTS AND METHODS: In this open-label study, 21 children diagnosed with LMs were given oral sildenafil and stopped at week 24...
January 17, 2017: Acta Oto-laryngologica
Yang Xu, Wei Ping Yang, Bo Hua Hu, Shiming Yang, Donald Henderson
CONCLUSION: p53 and Bcl-2 (B-cell lymphoma 2) are involved in the process of sensory cell degeneration in aging cochleae. OBJECTIVE: To determine molecular players in age-related hair cell degeneration, this study examined the changes in p53 and Bcl-2 expression at different stages of apoptotic and necrotic death of hair cells in aging rat cochleae. METHODS: Young (3-4 months) and aging (23-24 months) Fisher 344/NHsd rats were used. The thresholds of the auditory brainstem response (ABR) were measured to determine the auditory function...
January 17, 2017: Acta Oto-laryngologica
Hiroshi Yoshida, Shigeyuki Murono, Takayoshi Ueno, Yosuke Nakanishi, Akira Tsuji, Miyako Hatano, Kazuhira Endo, Satoru Kondo, Hisashi Sugimoto, Naohiro Wakisaka, Tomokazu Yoshizaki
CONCLUSION: The detection of human papillomavirus (HPV)-DNA in oral rinse with auto-nested GP5+/GP6 + PCR is useful as a biomarker of oropharyngeal cancer. BACKGROUND: This study aimed to determine the usefulness of oral rinse to detect HPV-DNA as a biomarker of HPV-positive oropharyngeal cancer (OPC). PATIENTS AND METHODS: One hundred and ten patients with various head and neck diseases, including 19 patients with OPC, were enrolled. Oral rinse and tonsillar swab were collected, and auto-nested GP5+/GP6 + PCR for HPV-DNA was performed...
January 17, 2017: Acta Oto-laryngologica
Jorge Otero-Millan, Carolina Treviño, Ariel Winnick, David S Zee, John P Carey, Amir Kheradmand
CONCLUSION: vOCR can detect loss of otolith-ocular function without specifying the side of vestibular loss. Since vOCR is measured with a simple head tilt maneuver, it can be potentially used as a bedside clinical test in combination with video head impulse test. OBJECTIVE: Video-oculography (VOG) goggles are being integrated into the bedside assessment of patients with vestibular disorders. Lacking, however, is a method to evaluate otolith function. This study validated a VOG test for loss of otolith function...
January 13, 2017: Acta Oto-laryngologica
Xiao-Kai Yang, Yan-Yan Zheng, Xiao-Guo Yang
CONCLUSION: To make a comprehensive analysis with a variety of diagnostic maneuvers is conducive to the correct diagnosis and classification of BPPV. OBJECTIVE: Based on the standard spatial coordinate-based semicircular canal model for theoretical observation on diagnostic maneuvers for benign paroxysmal positional vertigo (BPPV) to analyze the meaning and key point of each step of the maneuver. MATERIALS AND METHODS: This study started by building a standard model of semicircular canal with space orientation by segmentation of the inner ear done with the 3D Slicer software based on MRI scans, then gives a demonstration and observation of BPPV diagnostic maneuvers by using the model...
January 13, 2017: Acta Oto-laryngologica
Mosaad Abdel-Aziz, Noha Azab, Hisham Lasheen, Nader Naguib, Ramez Reda
CONCLUSION: Diffuse idiopathic skeletal hyperostosis (DISH) is a cause of swallowing disorders in elderly, and otolaryngologists should be aware of the disease on dealing with old patients complaining of dysphagia. The condition may be treated conservatively in most patients; however, surgical reduction of cervical osteophytes may be needed in severe cases. OBJECTIVE: Large cervical osteophytes may cause dysphagia; they compress the pharynx leading to mechanical impairment of swallowing...
January 13, 2017: Acta Oto-laryngologica
Lijuan Li, Ting Xu, Yu Song, Yan Yan, Furong Ma, Li Wang
CONCLUSION: Airtraq(®) laryngoscope can obviously improve laryngeal visualization and may provide a useful solution to treatment of patients with difficult laryngeal exposure (DLE) under a conventional suspension laryngoscope in phonomicrosurgery. OBJECTIVE: In phonomicrosurgery, otolaryngologists may inevitably encounter DLE. Attempts to improve laryngeal exposure have yielded important advances, but the prevalence of DLE yet remains persistent. To overcome this problem, this study applied the Airtraq(®) laryngoscope to perform phonomicrosurgery combined with a video system...
January 13, 2017: Acta Oto-laryngologica
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