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Acta Oto-laryngologica

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https://www.readbyqxmd.com/read/28549396/molecular-mechanisms-underlying-the-protective-effects-of-hydrogen-saturated-saline-on-noise-induced-hearing-loss
#1
Liwei Chen, Mingkun Han, Yan Lu, Daishi Chen, Xuejun Sun, Shiming Yang, Wei Sun, Ning Yu, Suoqiang Zhai
OBJECTIVES: This study aimed to explore the molecular mechanism of the protective effects of hydrogen-saturated saline on NIHL. METHODS: Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily abdominal injections 3 d before and 1 h before noise exposure. ABR were tested to examine cochlear physiology changes. The changes of 8-hydroxy-desoxyguanosine (8-HOdG), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), intercellular cell adhesion molecule-1 (ICAM-1) and high mobility group box-1 protein (HMGB1) in the cochlea were also examined...
May 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28549389/correction-to-huang-h-et%C3%A2-al-m2-polarized-tumour-associated-macrophages-in-stroma-correlate-with-poor-prognosis-and-epstein-barr-viral-infection-in-nasopharyngeal-carcinoma
#2
(no author information available yet)
No abstract text is available yet for this article.
May 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28541825/surgical-treatment-of-vertigo-in-cochlear-implantees-by-electrode-resealing
#3
Dania Karimi, Philipp Mittmann, Arneborg Ernst, Ingo Todt
CONCLUSION: Our present findings demonstrate that resealing to cover the electrode is an effective method to treat vertigo after CI. An insufficient cochleostomy sealing can be regarded as a cause of postoperatively newly occuring vertigo after CI. A transtympanic revision is a promising treatment option in cases of post-operative dizziness. Intoduction: A well-known and frequently reported complication after cochlear implantation is the appearance of postoperative vertigo symptoms. The aim of the present study was to observe if the postoperatively new occurrence of vertigo can be treated by resealing of the round window patch after cochlear implantation...
May 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28541766/the-clinical-utility-of-vestibular-autorotation-test-in-patients-with-vestibular-migraine
#4
Yogun Thungavelu, Wei Wang, Peng Lin, Taisheng Chen, Kaixu Xu
OBJECTIVE: To investigate the characteristics and clinical utility of vestibular autorotation test (VAT) in patients with vestibular migraine. METHODS: This study included two groups, an experimental group (441 patients) and a control group (65 healthy subjects). Both groups undertook VAT; the parameters evaluated were horizontal gain/phase, vertical gain/phase and asymmetry. The differences in VAT results between the two groups were investigated. RESULTS: There were no statistical differences between the VAT data of the control group when compared to the reference value from the manufacturer (p > ...
May 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28537142/perceived-direction-of-gravity-and-the-body-axis-during-static-whole-body-roll-tilt-in-healthy-subjects
#5
Atsushi Tamura, Yoshiro Wada, Takuo Inui, Akihiro Shiotani
OBJECTIVE: We used the subjective visual vertical (SVV) and two different subjective visual body axis (SVBA) methods to quantify roll-tilt perception under gravity, and investigated the characteristics of these methods during static roll-tilt. In addition, we independently developed a compact device to facilitate evaluation of SVBA in different gravitational environments. METHODS: Ten male volunteers participated in this study. We created a roll-tilt environment using a flight simulator in a dark room...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28537107/clinical-and-audiological-short-term-and-long-term-outcomes-of-fat-graft-myringoplasty
#6
Johan Knutsson, Annika Kahlin, Magnus von Unge
INTRODUCTION: Results of fat graft myringoplasty are often reported with only short-term follow-up. Audiological results are less commonly reported, as well as long-term follow-up results. MATERIALS AND METHODS: One hundred consecutive patients scheduled for fat graft myringoplasty were included in a prospective cohort study. Clinical and audiological outcomes were assessed at six weeks and one year postoperatively. RESULTS: Perforation sizes ranged from 0...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28537102/cisplatin-induced-metabolome-changes-in-serum-an-experimental-approach-to-identify-markers-for-ototoxicity
#7
Pernilla Videhult Pierre, Jakob Haglöf, Birgitta Linder, Mikael K R Engskog, Torbjörn Arvidsson, Curt Pettersson, Anette Fransson, Göran Laurell
BACKGROUND: Ototoxicity from treatment with the anticancer drug cisplatin remains a clinical problem. A wide range of intracellular targets of cisplatin has been found in vivo. AIM: To investigate cisplatin-induced change of the serum metabolite profile and its association with ototoxicity. MATERIAL AND METHODS: Guinea pigs (n = 14) were treated with cisplatin (8 mg/kg b.w., i.v.) 30 min after administration of the otoprotector candidate sodium thiosulfate (group STS; n = 7) or sodium chloride (group NaCl; n = 7)...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28537101/clinical-findings-in-25-patients-with-sinonasal-or-nasopharyngeal-extramedullary-plasmacytoma-in-a-four-decade-single-centre-series
#8
Seija Inkeri Vento, Pauli Vähämurto, Kaija Silventoinen, Marja-Liisa Karjalainen-Lindsberg, Susanna Mannisto, Sirpa Leppä, Antti Aarni Mäkitie
OBJECTIVES: Extramedullary plasmacytoma in the sinonasal tract or nasopharynx is rare. The aim of the study was to review data on symptoms, clinical findings, treatment and follow-up of plasmacytomas in the sinonasal and nasopharyngeal regions in order to delineate the main clinical characteristics and the optimal management. METHOD: Twenty-five patients with sinonasal or nasopharyngeal plasmacytoma, diagnosed and treated at the Helsinki University Hospital during a 39-year period from 1975 to 2013 were retrospectively reviewed...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28532297/preoperative-assessment-of-stapes-implantations-of-the-vibrant-soundbridge-for-congenital-aural-atresia-patients
#9
Danni Wang, Demin Han, Shouqin Zhao, Ran Ren, Jiyong Dong
OBJECTIVE: The objective of this study is to retrospectively analyze the imaging characteristics of patients with congenital aural atresia who underwent Vibrant Soundbridge implantation, and to investigate the importance of preoperative evaluation of vibroplasty. MATERIALS AND METHODS: The study included 16 patients with bilateral congenital aural atresia aged 6-25 years (mean age, 14.7 years). All patients underwent Vibrant Soundbridge implantations. RESULTS: Among the 16 patients, 15 successfully underwent stapes implantation...
May 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28504000/factors-associated-with-successful-decannulation-in-pediatric-tracheostomy-patients
#10
Nozomi Takahashi, Kenichi Takano, Hiroaki Mitsuzawa, Maokoto Kurose, Tetsuo Himi
OBJECTIVES: To investigate the outcome of pediatric tracheostomy and identify predictive factors for successful decannulation. METHODS: We performed a retrospective chart review of a series of 42 consecutive patients of less than 24 months of age who underwent a tracheostomy between 2012 and 2015. RESULTS: Successful decannulation was achieved in 11 patients (26%). Thirty-one patients (74%) remained tracheostomy-dependent. Of the 11 patients who were successfully decannulated, 10 (91%) had only structural disorders and nine (82%) were able to walk unassisted; importantly, nine (82%) were able to swallow following decannulation...
May 14, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28503992/dose-dependent-effects-of-ouabain-on-spiral-ganglion-neurons-and-schwann-cells-in-mouse-cochlea
#11
Zhi-Jian Zhang, Hong-Xia Guan, Kun Yang, Bo-Kui Xiao, Hua Liao, Yang Jiang, Tao Zhou, Qing-Quan Hua
OBJECTIVE: This study aimed in fully investigating the toxicities of ouabain to mouse cochlea and the related cellular environment, and providing an optimal animal model system for cell transplantation in the treatment of auditory neuropathy (AN) and sensorineural hearing loss (SNHL). METHODS: Different dosages of ouabain were applied to mouse round window. The auditory brainstem responses and distortion product otoacoustic emissions were used to evaluate the cochlear function...
May 14, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28503989/intravenous-olfactory-test-latency-correlates-with-improvement-in-post-infectious-olfactory-dysfunction
#12
Kyohei Horikiri, Shu Kikuta, Kaori Kanaya, Yuya Shimizu, Hironobu Nishijima, Tatsuya Yamasoba, Kenji Kondo
CONCLUSION: This cohort study showed that onset latency in the intravenous olfactory test (IVO) may help predict when olfaction in patients with post-infectious olfactory dysfunction (PIOD) improves. OBJECTIVES: To identify factors that predict the olfactory improvement period in patients with PIOD. METHODOLOGY/PRINCIPAL: All consecutive patients presenting with PIOD in 1994-2014 who were followed up for 2 years were identified retrospectively...
May 14, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28503988/the-usefulness-of-narrow-band-imaging-for-the-diagnosis-and-treatment-of-vocal-fold-leukoplakia
#13
Fang Huang, Jinchao Yu, Fan Zhang, Changding He, Shimin Li, Jun Shao
OBJECTIVE: This research was aimed to explore the efficacy of narrow-band imaging (NBI) on distinguishing the degree of dysplasia of vocal fold leukoplakia. METHODS: Patients were examined by flexible endoscopy, under white light endoscopy (WLE) and NBI. 78 lesions were divided into two groups according to the NBI classification. Group 1: non-dysplasia (ND), including squamous hyperplasia with hyperkeratosis or parakeratosis; Group 2: squamous hyperplasia with mild or moderate dysplasia (MD) or severe dysplasia (SD), or carcinoma in situ (CIS)...
May 14, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28485669/postural-stability-in-a-population-of-dancers-healthy-non-dancers-and-vestibular-neuritis-patients
#14
Eduardo Martin-Sanz, Isabel Ortega Crespo, Jonathan Esteban-Sanchez, Ricardo Sanz
INTRODUCTION: Several studies have indicated better balance control in dancers than in control participants, but some controversy remains. The aim of our study is to evaluate the postural stability in a cohort of dancers, non-dancers, compensated, and non-compensated unilateral vestibular neuritis (VN). METHODS: This is a prospective study of control subjects, dancers, and VN patients between June 2009 and December 2015. Dancers from the Dance Conservatory of Madrid and VN patients were referred to our department for analysis...
May 9, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28471721/comparison-of-treatment-outcomes-between-10-and-20-eeg-electrode-location-system-guided-and-neuronavigation-guided-repetitive-transcranial-magnetic-stimulation-in-chronic-tinnitus-patients-and-target-localization-in-the-asian-brain
#15
Tae-Soo Noh, Yoon-Chan Rah, Jeong Sug Kyong, June Sic Kim, Moo Kyun Park, Jun Ho Lee, Seung Ha Oh, Chun Kee Chung, Myung-Whan Suh
OBJECTIVE: rTMS is a non-invasive method that applies a brief magnetic pulse to the cortex and is regarded as a possible therapeutic method for tinnitus control. However, it remains unclear whether the rTMS treatment effect would be the same in tinnitus patients receiving the 10-20 EEG-based target localization as in those receiving imaging-based neuronavigation target localization. METHODS: We compared the treatment outcome of the 10-20 EEG-guided rTMS (Group 1) with that of the neuronavigation-guided rTMS (Group 2)...
May 4, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28471720/effects-of-mechanical-trauma-to-the-human-tympanic-membrane-an-experimental-study-using-transmission-electron-microscopy
#16
Nadine Schart-Morén, Paula Mannström, Helge Rask-Andersen, Magnus von Unge
HYPOTHESIS: To examine the cellular events following induced superficial lesions of the human tympanic membrane (TM). Such information could lead to enhanced appreciation of repair mechanisms and novel strategies to restore TM perforations. BACKGROUND: Persistent perforation of the TM in chronic otitis media is a major global health problem and frequently necessitates surgical intervention. Most TM perforations heal spontaneously and swiftly, but sometimes healing fails...
May 4, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28471705/individualized-management-of-facial-synkinesis-based-on-facial-function
#17
Cecilia Montalban Maria, Jin Kim
OBJECTIVES: The researchers analyzed facial patterns in subjects with facial synkinesis after facial paralysis and evaluated the involved muscles to aid in the development of effective treatments for facial synkinesis. METHODS: A total of 142 subjects were included in the study, the primary measure for synkinesis was determined by video analysis involving the strongest combination of two muscle groups that contributed to facial expression. The secondary measure of synkinesis was the analysis of its severity using the SB grading system, while observing the number of facial synkinetic movements...
May 4, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28471702/adeno-associated-virus-transformation-into-the-normal-miniature-pig-and-the-normal-guinea-pigs-cochlea-via-scala-tympani
#18
Xunbei Shi, Nan Wu, Yue Zhang, Weiwei Guo, Chang Lin, Shiming Yang
OBJECTIVE: To investigate the expression of the miniature pig cochlea after AAV1 transfect into the cochlea via round window membrane (RWM). METHODS: Twenty miniature pigs are equally divided into four experimental groups. Twelve miniature pigs are equally divided into four control groups. Each pig was transfected with the AAV1 in the experimental group via RWM and each pig was transduced with the artificial perilymph in the control group. The expression of green fluorescent protein (GFP) was observed at 2 weeks, 3 weeks and 4 weeks, respectively...
May 4, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28471689/the-effect-of-tonsillotomy-on-chronic-recurrent-tonsillitis-in-children
#19
Elisabeth Foki, Rudolf Seemann, Klaus Stelter, Claudia Lill
OBJECTIVES: The objective of this study is to determine whether partial tonsillectomy (tonsillotomy) impacts the occurrence of acute or recurrent tonsillitis in children. METHODS: One hundred and eighty patients (1-14 years) were retrospectively surveyed by a questionnaire or by data analysis of a regional database. Subjects who suffered from severe systemic diseases or immunodeficiency syndromes were excluded. Episodes of acute tonsillitis before and after surgery, rate of antibiotic treatment, postoperative hemorrhage, and re-operation were obtained...
May 4, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28446044/extracapsular-dissection-for-warthin-tumor-in-the-tail-of-parotid-gland
#20
Dong Hoon Lee, Tae Mi Yoon, Joon Kyoo Lee, Sang Chul Lim
CONCLUSIONS: Extracapsular dissection conferred the advantage of reduced operation time and morbidity without any recurrence, and it could be considered as the treatment of choice for Warthin tumors in the tail of the parotid gland. OBJECTIVE: The purpose of this study is to confirm the appropriate surgical procedure for Warthin tumor in the tail of the parotid gland, by comparing the results of extracapsular dissection and superficial parotidectomy. MATERIALS AND METHODS: The medical records of 72 patients with Warthin tumor in the tail of the parotid gland who underwent surgery between January 2006 and December 2016 were retrospectively reviewed...
April 27, 2017: Acta Oto-laryngologica
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