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Acta Oto-laryngologica

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https://www.readbyqxmd.com/read/29764277/human-papillomavirus-hpv-is-absent-in-branchial-cleft-cysts-of-the-neck-distinguishing-them-from-hpv-positive-cystic-metastasis
#1
Lars Sivars, David Landin, Marzia Rizzo, Linnea Haeggblom, Cinzia Bersani, Eva Munck-Wikland, Anders Näsman, Tina Dalianis, Linda Marklund
BACKGROUND: Distinguishing branchial cleft cysts (BCCs) from cystic metastases of a human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is challenging. Fine needle aspirates (FNAs) from cystic metastasis may be non-representative, while reactive squamous cells from BCC can be atypic. Based on cytology and with the support of HPV DNA positivity many centers treat cystic metastasis oncological and thus patients are spared neck dissection. To do so safely, one must investigate whether HPV DNA and p16INK4a overexpression is found exclusively in cystic metastases and not in BCC...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29764274/delayed-transmastoid-facial-nerve-decompression-surgery-in-patients-with-ramsay-hunt-syndrome-presenting-with-neurophysiologically-complete-paralysis
#2
Yoshihiko Kumai, Momoko Ise, Satoru Miyamaru, Yorihisa Orita
OBJECTIVES: To determine the efficacy of delayed transmastoid facial nerve decompression in patients with Ramsay Hunt Syndrome (RHS) presenting with complete facial paralysis. METHODS: Twenty-five RHS patients with complete facial nerve paralysis presenting electroneuronographic (ENoG) degeneration ≥90% underwent transmastoid facial nerve decompression more than 3 weeks after the onset of paralysis. The principal features measured were 12 months pre- and post-operative House-Brackmann (HB) grades and the presence of a direct intraoperative neural response (INR) prior to decompression procedure...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29764271/effect-of-intratympanic-steroid-injection-in-light-cupula
#3
Jin Su Park, So Yean Kim, Min-Beom Kim
OBJECTIVE: To evaluate the effects of intratympanic steroid injection (ITS) in light cupula. METHODS: A total of 47 patients showing persistent geotropic direction-changing positional nystagmus with null point (light cupula) were randomly classified into three groups: ITS (n = 15), vestibular suppressant (VS, n = 16) and canalith repositioning procedure (CRP, n = 16). Positional nystagmus and dizziness severity by dizziness handicap inventory (DHI) and visual analogue scale (VAS) were conducted before and 3 d and 1 week after first treatment to compare the effect of each treatment...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29764268/magnesium-as-an-intrinsic-component-of-human-otoconia
#4
Leif Erik Walther, Jana Wulfes, Alexander Blödow, Rüdiger Kniep
OBJECTIVES: To investigate morphology changes of artificial otoconia (CGC) in the presence of magnesium during growth under in vitro conditions. METHODS: Investigating human otoconia by environmental scanning electron microscope and determining their magnesium content by energy-dispersive X-ray microanalysis (EDX). Comparing structural and morphological data of human and artificial otoconia (CGC, Ca1 Mg0 ) without and with magnesium substitution (Ca1-x Mgx ). RESULTS: EDX- and X-ray data reveals that the inorganic component in human otoconia consists of calcite containing a minor amount of magnesium substitution (Ca1-x Mgx )...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29764263/categorical-perception-of-lexical-tones-in-native-mandarin-speaking-listeners-with-sensorineural-hearing-loss
#5
Beier Qi, Peng Liu, Xin Gu, Ruijuan Dong, Bo Liu
BACKGROUND: Categorical perception (CP) of lexical tones was examined in normal hearing (NH) people, but it was unclear whether lexical tones can be perceived categorically in sensorineural hearing loss (SNHL) people. OBJECTIVES: To explore the characteristic of lexical tone perception in native Mandarin speakers with SNHL. MATERIALS AND METHODS: Three types of continuum (Tone1/Tone2, Tone1/Tone4 and Tone2/Tone3) were constructed and each of them includes 15 stimuli which were resynthesized by applying the pitch-synchronous overlap and add (PSOLA) method implemented in Praat to the same Mandarin syllable, /a/, with a high-level tone produced by a female speaker...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29741433/familial-nonsyndromic-hearing-loss-with-incomplete-partition-type-ii-caused-by-novel-dspp-gene-mutations
#6
Wan-Xin Li, Hong Peng, Le Yang, Qing-Qing Hao, Wei Sun, Fei Ji, Wei-Wei Guo, Shi-Ming Yang
BACKGROUND: Familial nonsyndromic hearing loss (NSHL) with incomplete partition type II (IP-II) is a very rare condition. AIMS/OBJECTIVES: To determine the audiological feature, inheritance patterns and genetic etiology of familial NSHL with IP-II in a Chinese family with eight family members. MATERIAL AND METHODS: Clinical data were collected from all eight family members, selected deafness genes were sequenced in proband and whole genome sequencing of seven family members was performed...
May 9, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29741428/hpv-16-viral-load-in-oropharyngeal-squamous-cell-carcinoma-using-digital-pcr
#7
Annika Antonsson, Lani Knight, Benedict J Panizza, Sandro V Porceddu, Sarah Emmett, David C Whiteman
CONCLUSIONS: We did not identify any strong associations between HPV-16 viral load and any of the clinical or lifestyle factors. OBJECTIVE: The epidemiology of oropharyngeal SCC is changing, with an increasing proportion of HPV-positive cases seen in the last decade. It is known that a high viral load is linked to the development of cervical cancer, the relation between viral load and oropharyngeal SCC is less clear. We sought to determine HPV-16 viral load in HPV-positive oropharyngeal SCCs using highly sensitive digital PCR and to identify clinical and lifestyle factors associated with viral load...
May 9, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29741427/time-course-of-subacute-pain-after-transoral-robotic-surgery-tors-for-oropharyngeal-squamous-cell-carcinoma-versus-traditional-bilateral-tonsillectomy-in-adults-a-case-control-study
#8
Susanne Irene Scott, Anne Kathrine Østergaard Madsen, Niclas Rubek, Hani Ibrahim Channir, Henrik Kehlet, Christian von Buchwald
OBJECTIVE: To examine pain after Transoral Robotic Surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) versus traditional bilateral tonsillectomy in adults. METHODS: Pain evolvement was assessed in a prospective case-control design of 16 consecutive patients treated with TORS for early stage OPSCC versus 12 patients, who underwent bilateral tonsillectomy on suspicion of malignant disease. The TORS group received an optimized analgesia regime of preoperative oral celecoxib and gabapentin, intra- and postoperative high-dose intravenous dexamethasone, and regular postoperative oral contalgin, gabapentin, celecoxib, paracetamol and rescue morphine...
May 9, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29656688/sensory-preservation-in-neck-dissection-outcomes-of-a-sub-sternocleidomastoid-approach
#9
Keigo Honda, Ryo Asato, Jun Tsuji, Masakazu Miyazaki, Shinpei Kada, Yukiko Kataoka, Akiko Taura, Mami Morita
OBJECTIVE: Cutaneous anesthesia in early postoperative period is common after neck dissection even if the cervical nerve (CN) rootlets are preserved. The aim of this study was to evaluate if the preservation of the terminal branches of CNs using sub-sternocleidomastoid (SCM) approach combined with medially placed skin incision can prevent early postoperative anesthesia. MATERIAL AND METHODS: A retrospective chart review was performed on 129 neck dissections in 87 head and neck cancer patients...
April 14, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29656683/clinicopathologic-analysis-of-2736-salivary-gland-cases-over-a-11-year-period-in-southwest-china
#10
S Y Shen, W H Wang, R Liang, G Q Pan, Y M Qian
OBJECTIVE: To investigate the epidemiological and clinicopathological characteristics of salivary gland tumors in southwest China in order to provide data for clinical diagnosis and other similar research. METHODS: Between March 2007 and December 2017, 2736 patients with salivary gland tumors were recruited, the clinical and pathological data were retrospectively analyzed. RESULTS: A total of 2736 patients had a ratio of males to females of about 1...
April 14, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29607748/auditory-brainstem-implant-in-postmeningitis-totally-ossified-cochleae
#11
Andréa Felice Dos Santos Malerbi, Maria Valéria Schmidt Goffi-Gomez, Robinson Koji Tsuji, Marcos de Queiroz Teles Gomes, Rubens de Brito Neto, Ricardo Ferreira Bento
INTRODUCTION: An auditory brainstem implant (ABI) is an option for auditory rehabilitation in patients with totally ossified cochleae who cannot receive a conventional cochlear implant. OBJECTIVE: To evaluate the outcomes in audiometry and speech perception tests after the implantation of an ABI via the extended retrolabyrinthine approach in patients with postmeningitis hearing loss. MATERIALS AND METHODS: Ten patients, including children and adults, with postmeningitis hearing loss and bilateral totally ossified cochleae received an ABI in a tertiary center from 2009 to 2015...
April 1, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29607744/pretreatment-lymphocyte-to-monocyte-ratio-as-an-independent-prognostic-factor-for-hypopharyngeal-squamous-cell-carcinoma
#12
Jiechao Yang, Chi-Yao Hsueh, Wenjun Cao, Liang Zhou
OBJECTIVE: The aim of this work was to analyze the clinical characteristics and pretreatment peripheral blood cell counts of patients with hypopharyngeal squamous cell carcinoma (HPSCC) and determine their relationship with clinical outcomes. METHODS: One hundred ninety-seven patients were eligible for the study. The relationship between survival and pretreatment peripheral absolute neutrophil count (ANC), absolute lymphocyte count (ALC), absolute monocyte count (AMC), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR) were analyzed by one-way analysis of variance, t-test, and univariate and multivariate analysis...
April 1, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29607712/expression-of-aquaporins-mrnas-in-patients-with-otitis-media
#13
Su Young Jung, Sung Su Kim, Young Il Kim, Hyung-Sik Kim, Sang Hoon Kim, Seung Geun Yeo
OBJECTIVE: This study analyzed the associations between measured levels of aquaporin (AQP) mRNAs and clinical manifestations in patients with various types of otitis media (OM). METHODS: AQP1, 2, 3, 4, 5, 6, 8, and 10 mRNA levels were assayed by real-time PCR from 57 patients with chronic otitis media (COM), 24 patients with cholesteatomatous otitis media (choleOM), and 82 patients with otitis media with effusion (OME). The relationships of these mRNA levels with the presence of bacteria, the type of hearing loss, and clinical manifestations of OM types were evaluated...
April 1, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29553844/estimation-of-the-status-of-spiral-ganglion-neurons-and-schwann-cells-in-the-auditory-neural-degeneration-mouse-using-the-auditory-brainstem-response
#14
Zhi-Jian Zhang, Hong-Xia Guan, Kun Yang, Bo-Kui Xiao, Hua Liao, Yang Jiang, Tao Zhou, Qing-Quan Hua
CONCLUSION: The auditory brainstem response (ABR) wave I threshold, latency and amplitude are insensitive to spiral ganglion neurons (SGNs) degeneration, but are sensitive to the degeneration of Schwann cells and can estimate the status of Schwann cells in a neural degeneration mouse model. The thorough pre-operative ABR assessment would be helpful in predicting cochlear implant performance. OBJECTIVES: This study aimed in finding a non-invasive electrophysiological method to evaluate the status of the auditory nerve and the Schwann cells in sensorineural hearing loss (SNHL) and auditory neuropathy (AN) ears, and providing useful information for candidates screening and outcome prediction in cochlear implantation...
March 19, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29553839/bimodal-benefit-for-cochlear-implant-listeners-with-different-grades-of-hearing-loss-in-the-opposite-ear
#15
Ulrich Hoppe, Thomas Hocke, Frank Digeser
OBJECTIVE: To determine speech perception in quiet and noise of adult cochlear implant listeners retaining a hearing aid contralaterally. Second, to investigate the influence of contralateral hearing thresholds and speech perception on bimodal hearing. PATIENTS AND METHODS: Sentence recognition with hearing aid alone, cochlear implant alone and bimodally at 6 months after cochlear implantation were assessed in 148 postlingually deafened adults. Data were analyzed for bimodal summation using measures of speech perception in quiet and in noise...
March 19, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29519185/canal-wall-down-procedure-with-soft-posterior-meatal-wall-reconstruction-in-acquired-cholesteatoma-focus-on-postoperative-middle-ear-status
#16
Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Michihiro Nakada, Takuma Makino, Yasutoshi Komatsubara, Yuko Matsuyama, Yuto Naoi, Kazunori Nishizaki
OBJECTIVES: We reviewed surgical results of canal wall-down tympanoplasty (CWDT) with soft posterior meatal wall reconstruction (SWR) for acquired cholesteatoma (AC), and identified factors associated with surgical outcomes. METHODS: Results from 119 ears with AC (pars flaccida, n = 99; pars tensa, n = 20) that underwent CWDT with SWR were retrospectively reviewed. We defined postoperative balloon-like retraction (PBR) with web formation, which needed reoperation to clean accumulated cerumen, as postoperative deep retraction pocket (PDRP)...
March 8, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29513124/a-rational-approach-to-identifying-newborns-with-hearing-loss-caused-by-congenital-cytomegalovirus-infection-by-dried-blood-spot-screening
#17
Hideaki Moteki, Yuichi Isaka, Yuji Inaba, Mitsuo Motobayashi, Shin-Ya Nishio, Satoshi Ohira, Takuya Yano, Satoshi Iwasaki, Tanri Shiozawa, Kenichi Koike, Shin-Ichi Usami
OBJECTIVE: Congenital cytomegalovirus (cCMV) infection is the most common congenital infection, with the majority of infected newborns having no detectable signs. The aim of this study was to examine the accuracy of our newly developed DBS-based assay as an appropriate mass screening method for cCMV infection. METHODS: Between May 2011 and October 2016, newborns delivered at six hospitals in Nagano Prefecture, Japan were enrolled prospectively. We employed dried blood spot (DBS)-based assays with real-time quantitative PCR (qPCR)...
March 7, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29513120/assessment-of-lingual-sentinel-lymph-nodes-metastases-using-dual-modal-indirect-ct-mr-lymphography-with-gold-gadolinium-based-nanoprobes-in-a-tongue-vx-2-carcinoma-model
#18
Yue Yang, Benqing Zhou, Jian Zhou, Xiangyang Shi, Yan Sha, Haitao Wu
OBJECTIVE: To evaluate the capability of indirect computed tomography and magnetic resonance lymphography (CT/MR-LG) with gadolinium-loaded, polyethylenimine-entrapped gold nanoprobes (Gd-Au PENPs) for assessing lingual sentinel lymph node (SLN) metastasis in a tongue VX2 carcinoma model. MATERIALS AND METHODS: Seventeen rabbits were used to establish a metastatic cervical lymph node model by implanting VX2 carcinoma suspension into the ventral tongue muscle. CT and MR images were acquired one hour after Gd-Au PENPs injection into the tongue submucosa bilaterally, on 1w (n = 4), 2w (n = 6) and 3w (n = 7) tumour-bearing rabbits after carcinoma transplantation...
March 7, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29513064/contribution-of-intratympanic-steroids-in-the-primary-treatment-of-sudden-hearing-loss
#19
Hasan Demirhan, Ali Rıza Gökduman, Bahtiyar Hamit, Müge Fethiye Yürekli Altındağ, Özgür Yiğit
OBJECTIVE: The primary objective is to investigate the contribution of intratympanic steroids in the primary treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). The secondary objective is to compare methylprednisolone (MP) and dexamethasone in terms of their effectiveness and injection-site pain. METHODS: Two hundred and four patients with ISSNHL, 144 patients underwent systemic steroid therapy (SST) alone and 60 patients underwent combined therapy (CT)...
March 7, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29513056/l-n-acetylcysteine-protects-outer-hair-cells-against-tnf%C3%AE-initiated-ototoxicity-in-vitro
#20
Joshua A Tillinger, Chhavi Gupta, Kadri Ila, Jamal Ahmed, Jeenu Mittal, Thomas R Van De Water, Adrien A Eshraghi
OBJECTIVE: The present study is aimed at determining the efficacy and exploring the mechanisms by which l-N-acetylcysteine (l-NAC) provides protection against tumor necrosis factor-alpha (TNFα)-induced oxidative stress damage and hair cell loss in 3-day-old rat organ of Corti (OC) explants. Previous work has demonstrated a high level of oxidative stress in TNFα-challenged OC explants. TNFα can potentially play a significant role in hair cell loss following an insult to the inner ear...
March 7, 2018: Acta Oto-laryngologica
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