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Acta Obstetricia et Gynecologica Scandinavica

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https://www.readbyqxmd.com/read/28815558/sequence-variants-in-esr1-and-oxtr-are-associated-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#1
Sara Yvonne Brucker, Liliane Frank, Simone Eisenbeis, Melanie Henes, Diethelm Wallwiener, Olaf Riess, Barbara Van Eijck, Dorit Schöller, Michael Bonin, Kristin Katharina Rall
INTRODUCTION: Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is characterized by congenital absence of the uterus and the upper two-thirds of the vagina in otherwise phenotypically normal females. It is found isolated or associated with renal, skeletal and other malformations. Despite of ongoing research, the etiology is mainly unknown. For a long time, the hypothesis of deficient hormone receptors as cause for MRKHS exists, and is supported by previous findings of our group. The aim of the present study was to identify unknown genetic causes for MRKHS and to compare them with data banks including a review of the literature...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28815550/fertility-preservation-in-women-with-borderline-ovarian-tumors-how-does-it-impact-disease-outcome-a-cohort-study
#2
Limor Helpman, Assaf Yaniv, Mario E Beiner, Sarit Aviel-Ronen, Tamar Perri, Gilad Ben-Baruch, Liat Hogen Ben-David, Ariella Jakobson-Setton, Jacob Korach
INTRODUCTION: Borderline ovarian tumors are typically indolent neoplasms. Since many are diagnosed in younger women, fertility conservation is an important consideration and has been advocated based on retrospective data. The objective of this study was to identify features impacting on recurrence and survival in a series of borderline ovarian tumors, and to assess the safety of a fertility-sparing approach. MATERIAL AND METHODS: A historical cohort study of consecutive borderline ovarian tumors cases treated at a single institution over 30 years (1981-2011)...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28815547/adjustable-mini-sling-compared-to-conventional-mid-urethral-slings-in-women-with-urinary-incontinence-a-randomized-controlled-trial
#3
Martin Rudnicki, Katarina von Bothmer-Ostling, Anja Holstad, Claes Magnusson, Memona Majida, Constanze Merkel, Jens Prien, Ulf Jakobsson, Pia Teleman
INTRODUCTION: The primary aim was to compare the objective and subjective outcomes and short-term complication rates of an adjustable single-incision mini-sling (SIMS) versus standard mid-urethral slings (SMUS). The secondary aim was reporting pain perception and complications at one-year follow-up. MATERIAL AND METHODS: The study was designed as a multicenter prospective randomized trial where women were included by eight centers in Denmark, Norway and Sweden. The trial was registered at ClinicalTrials...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28815546/clusters-of-week-specific-maternal-gestational-weight-gain-pattern-and-their-association-with-birthweight-an-observational-cohort-study
#4
Huan Liang, Chuanmin Yin, Xinran Dong, Ganesh Acharya, Xiaotian Li
INTRODUCTION: Gestational weight gain (GWG) varies widely among different populations, and an inappropriate GWG is associated with adverse pregnancy outcomes. We aimed to investigate week-specific serial changes in GWG in an urban Chinese population to derive clusters of GWG pattern and explore the impact of GWG patterns on birthweight. MATERIAL AND METHODS: This was an observational cohort study of 6130 women delivered at a university hospital in Shanghai, China...
August 16, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28805942/maternal-and-neonatal-outcomes-following-abnormally-invasive-placenta-a-population-based-record-linkage-study
#5
Heather J Baldwin, Jillian A Patterson, Tanya A Nippita, Siranda Torvaldsen, Ibinabo Ibiebele, Judy M Simpson, Jane B Ford
INTRODUCTION: Abnormally invasive placenta (AIP) involves abnormal adherence of the placenta to the myometrium, and is associated with severe pregnancy complications such as blood transfusion and hysterectomy. Knowledge of outcomes has been limited by small sample sizes and a focus on maternal rather than neonatal outcomes. This study uses population-level data collected over ten years to investigate maternal and neonatal outcomes and trends in incidence of AIP (also known as placenta accreta, increta and percreta)...
August 14, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28804876/insulin-resistance-in-pregnant-women-with-and-without-polycystic-ovary-syndrome-and-measures-of-body-composition-in-offspring-at-birth-and-3-years-of-age
#6
Sara Kristín Finnbogadóttir, Dorte Glintborg, Tina Kold Jensen, Henriette Kyhl, Ellen A Nohr, Marianne Andersen
Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance in the non-pregnant state, but little is known about insulin sensitivity in the pregnant state. Our objective was to compare insulin resistance in pregnant women with and without PCOS and explore the impact of PCOS on body composition in offspring at birth and at 3 years of age MATERIAL AND METHODS: A prospective cohort study including 2548 live born singleton mother-child pairs residing in Odense municipality, Denmark, during 2010-2013...
August 14, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28795770/a-national-prospective-observational-study-of-first-recurrence-after-primary-treatment-for-gynecological-cancer-in-norway
#7
Ingvild Vistad, Line Bjørge, Olesya Solheim, Bent Fiane, Kurt Sachse, Jostein Tjugum, Siri Skrøppa, Anne Gry Bentzen, Trine Stokstad, Grete A Iversen, Helga B Salvesen, Gunnar B Kristensen, Anne Dørum
INTRODUCTION: Gynecological cancer patients are routinely followed up for 5 years after primary treatment. However, the value of such follow-up has been debated, as retrospective studies indicate that first recurrence is often symptomatic and occurs within 2-3 years of primary treatment. We prospectively investigated time to first recurrence, symptoms at recurrence, diagnostic procedures, and recurrence treatment in gynecological cancer patients after primary curative treatment. MATERIAL AND METHODS: Clinicians from 21 hospitals in Norway interviewed 680 patients with first recurrence of gynecological cancer (409 ovarian, 213 uterine, and 58 cervical cancer patients) between 2012 and 2016...
August 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28787767/e-cigarette-use-in-pregnancy-a-human-rights-based-approach-to-policy-and-practice
#8
Yvette Van Der Eijk, Anne Berit Petersen, Stella Aguinaga Bialous
The health risks associated with e-cigarette use in pregnancy are mostly unknown. Guidelines by the World Health Organization and national health agencies warn women against using e-cigarettes in pregnancy, however, in the UK, a recent multiagency guideline takes a different approach by not discouraging e-cigarette use in pregnancy. Furthermore, e-Voke(™) , an e-cigarette, has been approved for use in pregnancy in the UK. We analyze United Nations' human rights treaties to examine how they might inform best practice recommendations for e-cigarette use in pregnancy...
August 8, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28777448/prematurity-and-neonatal-outcome-including-congenital-malformations-after-maternal-malignancy-within-six-months-prior-or-during-pregnancy
#9
Zahra Sabeti Rad, Britt Friberg, Emir Henic, Lars Rylander, Olof Ståhl, Bengt Källén, Göran Lingman
INTRODUCTION: The proportion of women who postpone childbearing is increasing. As malignancy risk increases with age, pregnancy in connection with malignancy will become more common. MATERIAL AND METHODS: We compared infants born 1994-2011 to women with a malignancy within six months prior to the last menstrual period or during pregnancy with offspring of women without a previous malignancy. Five national registers were used RESULTS: A total of 790 women with a malignancy diagnosis from six months prior to the last menstrual period up to delivery were identified...
August 4, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28759117/fertility-options-in-transgender-and-gender-diverse-adolescents
#10
Gail Knudson
Transgender coverage in media is becoming more commonplace and children and adolescents from resource-rich countries are accessing transgender healthcare at an exponentially increasing rate. What factors should care providers, adolescents and parents/guardians or caretakers take into consideration with respect to fertility? The World Professional Association for Transgender Health (WPATH) is the only global interdisciplinary association that is solely devoted to transgender health. This article is protected by copyright...
July 31, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28742935/response-to-telling-the-whole-story-about-simulation-based-education
#11
Christopher W H Yau, Elena Pizzo, Steve Morris, David E Odd, Cathy Winter, Timothy J Draycott
We thank Barsuk et al. for their letter, "Telling the whole story about simulation-based education" (1). We acknowledge that our paper, "The cost of local, multi-professional obstetric emergencies training"(2), focussed on the cost of training and did not elaborate on cost savings, value for money or return on investment (ROI). The authors' call for a ROI analysis is welcome. Others have estimated the potential savings of obstetric training (3). This article is protected by copyright. All rights reserved.
July 25, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28742930/information-about-first-trimester-screening-and-self-reported-distress-among-pregnant-women-and-partners-comparing-two-methods-of-information-giving-in-sweden
#12
Peter Lindgren, Magdalena Stadin, Inger Blomberg, Karin Nordin, Hanna Sahlgren, Charlotta Ingvoldstad Malmgren
INTRODUCTION: Balanced information prior to prenatal diagnosis (PND) aims to help expectant parents to make an informed choice. However, it is important that the information does not increase the expectant parents' psychological distress. The aim was to examine psychological distress among expectant parents, before and after receiving information about PND, to evaluate the possible differences between two different procedures of information giving, and to evaluate the association between satisfaction with the information and psychological distress...
July 25, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28742216/the-fetuses-at-risk-approach-survival-analysis-from-a-fetal-perspective
#13
K S Joseph, Michael S Kramer
Several phenomena in contemporary perinatology create challenges for analyzing pregnancy outcomes. These include recent increases in iatrogenic delivery at late preterm and early term gestation which are incongruent with the belief that stillbirth and neonatal death risk decrease exponentially with advancing gestational age. Perinatal epidemiologists have also puzzled over the paradox of intersecting birth weight- and gestational age-specific perinatal mortality curves for decades. For example, neonatal mortality rates among preterm infants of women who smoke are substantially lower than neonatal mortality rates among preterm infants of non-smoking women, whereas the reverse pattern occurs at term gestation...
July 25, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28718876/is-there-a-revision-needed-of-the-current-figo-staging-system
#14
Joseph Menczer
The FIGO staging system has undergone many modifications since it first appeared in about the middle of the previous century. Due to the use of modern diagnostic tools, namely computed tomography, magnetic resonance imaging, positron emission tomography, sentinel lymph node biopsy and of neoadjuvant chemotherapy, certain gynecological cancer cases cannot be allocated to a specific stage if one wishes to adhere strictly to FIGO requirements. In these circumstances such cases remain actually unstaged. This should prompt appropriate modifications of the current FIGO staging system so that it fulfills its aims...
July 18, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28718223/self-management-of-stress-urinary-incontinence-via-a-mobile-app-2-year-follow-up-of-a-randomized-controlled-trial
#15
Victoria Hoffman, Lars Söderström, Eva Samuelsson
We investigated the long-term effects of using a mobile app to treat stress urinary incontinence with a focus on pelvic floor muscle training (PFMT) MATERIAL AND METHODS: A previous randomized controlled trial of 123 women aged 27-72 years found that 3 months of self-managing stress urinary incontinence with support from the Tät(®) app was effective. We followed-up the women in the app group (n=62) two years after the initial trial with the same primary outcomes for symptom severity (International Consultation on Incontinence Questionnaire Short Form [ICIQ-UI SF]) and condition-specific quality of life (ICIQ-Lower Urinary Tract Symptom Quality of Life [ICIQ-LUTSqol]) and compared the scores with those at baseline RESULTS: Of the 62 women, 61 and 46 (75...
July 17, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28718198/targeted-antenatal-anti-d-prophylaxis-program-for-rhd-negative-pregnant-women-outcome-of-the-first-two-years-of-a-national-program-in-finland
#16
Katri Haimila, Kati Sulin, Malla Kuosmanen, Inna Sareneva, Anu Korhonen, Suvi Natunen, Jarno Tuimala, Susanna Sainio
The aim of this study was to assess the accuracy of the non-invasive fetal RHD test at 24-26 weeks of gestation as part of the national antenatal screening programme to target routine antenatal anti-D prophylaxis (RAADP) at 28-30 weeks at women carrying an RhD-positive fetus MATERIAL AND METHODS: A prospective cohort study involving all maternity care centres and delivery hospitals in Finland between February 2014 and January 2016. Fetal RHD genotyping using cell-free fetal DNA in maternal plasma was performed with real-time polymerase chain reaction in a centralised setting...
July 17, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28699189/human-papillomavirus-infects-placental-trophoblast-and-hofbauer-cells-but-appears-not-to-play-a-causal-role-in-miscarriage-and-preterm-labor
#17
Lea Maria Margareta Ambühl, Anne Katrine Leonhard, Carina Widen Zakhary, Annemette Jørgensen, Jan Blaakaer, Karen Dybkaer, Ulrik Baandrup, Niels Uldbjerg, Suzette Sørensen
INTRODUCTION: Recently, an association between human papillomavirus (HPV) infection and both spontaneous abortion and spontaneous preterm delivery was suggested. However, the reported HPV prevalence in pregnant women varies considerably and reliable conclusions are difficult. We aimed to investigate HPV infection in placental tissue of a Danish study cohort. Furthermore, we studied the cellular localization of HPV. MATERIAL AND METHODS: In this prospective case-control study, placental tissue was analyzed for HPV infection by nested PCR in the following four study groups: full-term delivery (n=103), spontaneous preterm delivery (n=69), elective abortion (n=54), and spontaneous abortion (n=44)...
July 12, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28683173/accelerated-fetal-growth-in-early-pregnancy-and-risk-of-severe-large-for-gestational-age-and-macrosomic-infant-a-cohort-study-in-a-low-risk-population
#18
Marija Simic, Anna-Karin Wikström, Olof Stephansson
INTRODUCTION: The aim of the study was to examine the association between fetal growth in early pregnancy and risk of severely large for gestational age (LGA) and macrosomia at birth in a low-risk population MATERIAL AND METHODS: Cohort study that included 68 771 women with non-anomalous singleton pregnancies, without history of diabetes or hypertension, based on electronic database on pregnancies and deliveries in Stockholm - Gotland Region, Sweden, 2008-2014. We performed multivariable logistic regression to estimate the association between accelerated fetal growth occurring in the first through early second trimester as measured by ultrasound and LGA and macrosomia at birth...
July 6, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28675781/telling-the-whole-story-about-simulation-based-education
#19
Jeffrey H Barsuk, William C McGaghie, Diane B Wayne
The work of Draycott et al. using simulators to train professionals on obstetric emergencies clearly shows that rigorous simulation-based education improves perinatal outcomes, safety attitudes, and teamwork climate (1). We read "The cost of local, multi-professional obstetric emergencies training" (2) with great interest. In their study, the authors report an annual cost for the obstetric training intervention of up to €148,000. Although this is important information, we are concerned that telling only half the story about simulation-based education may have a paradoxical effect...
July 4, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28664535/characterising-levator-ani-muscle-stiffness-pre-and-post-childbirth-in-european-and-polynesian-women-in-new-zealand-a-pilot-study
#20
Jennifer A Kruger, Stephanie C Budgett, Vivien Wong, Poul M F Nielsen, Martyn P Nash, Jackie Smalldridge, Lynsey M Hayward, Tania Yu Tian, Andrew J Taberner
INTRODUCTION: The influence of levator-ani muscles on second stage labour is poorly understood. The ability of these muscles to stretch without damage may affect birth outcomes, but little is known about material properties, effects of pregnancy and/or ethnicity on levator-ani stiffness. There are strong associations between muscle damage and subsequent pelvic floor disorders. This study aimed to quantify levator-ani muscle stiffness during the third trimester of pregnancy and postpartum in European and Polynesian women...
June 30, 2017: Acta Obstetricia et Gynecologica Scandinavica
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