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Acta Obstetricia et Gynecologica Scandinavica

Heléne E K Sundelin, Olof Stephansson, Kari Johansson, Jonas F Ludvigsson
INTRODUCTION: An increased risk of preterm birth in women with Joint Hypermobility Syndrome (JHS) or Ehlers-Danlos Syndrome (EDS) is suspected. MATERIAL AND METHODS: In this nationwide cohort study from 1997 through 2011, women with either JHS or EDS or both disorders were identified through the Swedish Patient Register, and linked to the Medical Birth Register. Thereby 314 singleton births to women with JHS/EDS before delivery were identified. These births were compared with 1,247,864 singleton births to women without a diagnosis of JHS/EDS...
October 14, 2016: Acta Obstetricia et Gynecologica Scandinavica
Shigeki Matsubara
Conservative management (leaving the placenta in situ) for abnormally invasive placenta (AIP: accreta, increta, percreta) has been repeatedly discussed in AOGS (1, 2). Delayed hemorrhage and infection are important adverse events. Especially, delayed hemorrhage required hysterectomy 3-9 months post-cesarean section in 22-58% of cases (1, 3), often performed as an emergency surgery (1, 3). Although delayed hysterectomy is not always associated with massive bleeding, a magnetic resonance imaging (MRI) showed marked gadolinium enhancement (marked blood flow) in the placental-bed-myometrium on post-cesarean day 34 (4), suggesting that hemorrhage may be serious during delayed hysterectomy at least up to one month post-cesarean...
October 14, 2016: Acta Obstetricia et Gynecologica Scandinavica
Torbjørn Moe Eggebø, Olav Andre Klefstad, Inger Økland, Elsa Lindtjørn, Sturla Hall Eik-Nes, Håkon Kristian Gjessing
INTRODUCTION: The aim of the study was to investigate the accuracy of estimating fetal weight with ultrasound in pregnancies past term, using the eSnurra algorithm. MATERIAL AND METHODS: 419 women with pregnancy length 290 days, attending a specialist consultation at Stavanger University Hospital, Norway were included in a prospective observational study. Fetal weight was estimated using biparietal diameter (BPD) and abdominal circumference (AC). The algorithm implemented in an electronic calculation (eSnurra) was used for estimated fetal weight (EFW) calculation...
October 14, 2016: Acta Obstetricia et Gynecologica Scandinavica
Sara Kjaer Bastholm, Mie Hesselund Samson, Naja Becher, Lea Kirstine Hansen, Peter Reimer Stubbe, Ioannis S Chronakis, Ebba Nexo, Niels Uldbjerg
INTRODUCTION: The viscoelastic properties of the cervical mucus plug are considered essential for the occlusion of the cervical canal and thereby for protection against ascending infections during pregnancy. Factors controlling this property are virtually unknown. This study explores a possible role of trefoil factor peptides 1, 2 and 3 (TFF1-3); peptides believed to influence mucus viscosity. MATERIALS AND METHODS: The study is based on spontaneously shed cervical mucus plugs from 14 women in active labor...
October 12, 2016: Acta Obstetricia et Gynecologica Scandinavica
Tilde B Østborg, Pål R Romundstad, Torbjørn M Eggebø
INTRODUCTION: The aim of the study was to compare the duration of active phase of labor in women with spontaneous or induced start of labor. MATERIAL AND METHODS: An observational cohort study was performed at Stavanger University Hospital in Norway between January 2010 and December 2013 and 19 524 women delivered during the study period. Data for the study were collected from an electronic birth journal. Women with previous cesarean section, multiple pregnancy, breech or transverse lie, preterm labor or prelabor cesarean section were excluded...
October 12, 2016: Acta Obstetricia et Gynecologica Scandinavica
Catharina Rydberg, Katarina Tunón
INTRODUCTION: This study assessed the sensitivity of routine ultrasound examination for the detection of abnormal chromosomes and structural malformations in fetuses in the second trimester in a non-selected population. MATERIAL AND METHODS: Prenatal diagnoses of fetal abnormalities in 10 414 fetuses and newborns were reviewed and compared with all postnatal diagnoses of congenital abnormalities between 2006 and 2013. RESULTS: Overall, 243 fetuses and newborns had confirmed congenital abnormalities, with a prevalence of 2...
October 7, 2016: Acta Obstetricia et Gynecologica Scandinavica
Sunila Shakya, Unni Syversen, Bjørn Olav Åsvold, Anna Mary Bofin, Guro Aune, Sven Arne Nordbø, Karishma Malla Vaidya, Biraj Man Karmacharya, Jan Egil Afset, Solveig Tingulstad
INTRODUCTION: In this study we aimed to determine the overall and type-specific prevalence of cervical human papillomavirus (HPV) infection and risk factors for such infection among women in rural Nepal, and to investigate the distribution of HPV infection by cervical cytology. MATERIAL AND METHODS: The study was conducted among women aged ≥ 15 years in five rural villages within Kavre District in Nepal. Socio-demographic data and information on risk factors for cervical cancer were obtained through an interview, and a cervical specimen was collected for HPV DNA detection and typing using the Anyplex(™) ll HPV28 Detection system, and for Papanicolaou test...
October 7, 2016: Acta Obstetricia et Gynecologica Scandinavica
Cathrine Ebbing, Synnøve Lian Johnsen, Susanne Albrechtsen, Ingvild Dahl Sunde, Christina Vekseth, Svein Rasmussen
INTRODUCTION: Anomalous cord insertion is associated with increased risk of adverse maternal and perinatal outcome. We aimed to study whether anomalous cord insertion is associated with prelabor rupture of membranes (PROM), preterm PROM (pPROM), long or short umbilical cord, and time trend of spontaneous preterm birth (SPTB) and anomalous cord insertion. MATERIAL AND METHODS: A population-based register study using data from the Medical Birth Register of Norway including all singleton births (gestational age >16 weeks and <45 weeks) during the period 1999-2013 (n=860465) to calculate odds ratios (ORs) for PROM, pPROM, SPTB, and cord length (>95(th) or <5(th) centile) according to the cord insertion site by logistic regression with adjustment for possible confounders...
October 3, 2016: Acta Obstetricia et Gynecologica Scandinavica
Merit Kullinger, Jan Wesström, Helle Kieler, Alkistis Skalkidou
INTRODUCTION: Gestational age is estimated by ultrasound using fetal size as a proxy for age, although variance in early growth affects reliability. The aim of this study was to identify characteristics associated with discrepancies between last menstrual period-based (EDD-LMP) and ultrasound-based (EDD-US) estimated delivery dates. MATERIAL AND METHODS: We identified all singleton births (n=1,201,679) recorded in the Swedish Medical Birth Register 1995-2010, to assess the association between maternal/fetal characteristics and large negative and large positive discrepancies (EDD-LMP earlier than EDD-US and10(th) percentile in the discrepancy distribution vs...
October 3, 2016: Acta Obstetricia et Gynecologica Scandinavica
Sandra Larsen, Joanna Dobbin, Oliver McCallion, Anne Eskild
INTRODUCTION: Vaginal delivery is recommended after intrauterine fetal death (IUFD). However, little is known about the risk of shoulder dystocia in these deliveries. We studied whether IUFD increases the risk of shoulder dystocia at delivery. MATERIAL AND METHODS: In this population-based register study using the Medical Birth registry of Norway, we included all singleton pregnancies with vaginal delivery of offspring in cephalic presentation in Norway during the period 1967-2012 (n=2 266 118)...
September 30, 2016: Acta Obstetricia et Gynecologica Scandinavica
Theodora C Van Tilborg, Frank J M Broekmans, Madeleine Dólleman, Marinus J C Eijkemans, Ben Willem Mol, Joop S E Laven, Helen L Torrance
INTRODUCTION: This systematic review examines whether individualised gonadotropin dosing in in-vitro fertilisation (IVF) leads to better outcomes with respect to safety, costs and live birth rates compared to standard dosing. MATERIAL AND METHODS: Electronic databases searched were PubMed, Embase and Cochrane. The primary outcome was live birth rate. The secondary outcomes included pregnancy rate, costs and safety. Papers were critically appraised by two reviewers...
September 30, 2016: Acta Obstetricia et Gynecologica Scandinavica
Giussy Barbara, Federica Facchin, Michele Meschia, Nicola Berlanda, Maria Pina Frattaruolo, Paolo Vercellini
INTRODUCTION: Endometriosis is associated with an increased risk of dyspareunia, therefore this chronic gynaecologic disease should be considered as a major cause of sexual dysfunctions. The aims of this study were to review the literature on the effects of endometriosis surgical and pharmacological treatments on female sexual functioning, and to provide suggestions for future treatment strategies. MATERIAL AND METHODS: We followed the PRISMA guidelines to conduct this systematic review, which involved an electronic database search of studies on the association between endometriosis and sexuality published between 2000 and 2016...
September 30, 2016: Acta Obstetricia et Gynecologica Scandinavica
Sanna Koivunen, Annukka Torkki, Aini Bloigu, Mika Gissler, Anneli Pouta, Eero Kajantie, Marja Vääräsmäki
INTRODUCTION: The change from risk-factor based to nearly comprehensive screening of gestational diabetes (GDM) identifies more but milder cases of the disease. The main aim of this study was to evaluate the effect of this screening policy change on neonatal outcomes and care. MATERIAL AND METHODS: A population-based register study in Finland. GDM cases during risk factor-based (year 2006, n=5179) and comprehensive (2010, n=6679) screenings were identified through Medical Birth Register...
September 28, 2016: Acta Obstetricia et Gynecologica Scandinavica
Tiina Vilmi-Kerälä, Outi Palomäki, Päivi Kankkunen, Leena Juurinen, Jukka Uotila, Ari Palomäki
INTRODUCTION: Gestational diabetes mellitus (GDM) is an indicator of future cardiovascular disease. We investigated if sensitive biomarkers of increased cardiovascular risk differ between women with and without a history of GDM few years after pregnancy, and whether obesity affects the results. MATERIAL AND METHODS: We studied two cohorts - 120 women with a history of GDM and 120 controls, on average 3.7 years after delivery. Circulating concentrations of oxidized low-density lipoprotein (oxLDL) were determined by ELISA...
September 28, 2016: Acta Obstetricia et Gynecologica Scandinavica
Marie Hargreave, Susanne Krüger Kjaer, Marit Eika Jørgensen, Allan Jensen
INTRODUCTION: While some studies have indicated that children born following fertility treatment are at an increased risk for insulin resistance and higher blood glucose levels, no study to date has investigated the risk of type 1 diabetes. In this large population-based cohort study we aim to assess the association between maternal fertility problems and the risk of type 1 diabetes in children. MATERIAL AND METHODS: Information on all children, born in Denmark from 1987 to 2010, was extracted from the Civil Registration System and linked with the Danish Infertility Cohort to identify maternal fertility status...
September 28, 2016: Acta Obstetricia et Gynecologica Scandinavica
Kirstine Sneider, Ole Bjarne Christiansen, Iben Blaabjerg Sundtoft, Jens Langhoff-Roos
INTRODUCTION: The objective was to describe recurrence rates of second trimester miscarriage and extreme preterm delivery by phenotype and use of prophylactic cerclage in a register-based cohort. MATERIAL AND METHODS: We included women with a first second trimester miscarriage or extreme preterm delivery (16(+0) - 27(+6) gestational weeks) in Denmark in 1997-2012 (n=9602) by combined use of the Danish Medical Birth Register and the Danish National Patient Register...
September 24, 2016: Acta Obstetricia et Gynecologica Scandinavica
Lan Yang, Ye Tang, Mudan Lu, Yuefen Yang, Jianpin Xiao, Qiaoxia Wang, Canfeng Yang, Hehua Tao, Xiangjing Ying
INTRODUCTION: Labor-intensive karyotyping is used as the gold standard diagnostic test to identify copy number variants (CNVs) in the fetal genome after recurrent pregnancy loss. Our aim was to present and evaluate a novel molecular assay called CNVplex that could potentially be used as an alternate method to conventional karyotyping for diagnosing fetal chromosomal abnormalities associated with recurrent pregnancy loss. MATERIAL AND METHODS: Using karyotyping as the reference standard, CNVplex was performed to identify fetal chromosomal abnormalities in the chorionic villus samples from 76 patients experiencing at least two pregnancy losses...
September 19, 2016: Acta Obstetricia et Gynecologica Scandinavica
Ioannis Papastefanou, Athanasios Pilalis, Dimitra Kappou, Athena P Souka
INTRODUCTION: Our aim was to establish unconditional and conditional longitudinal reference ranges for cervical length throughout pregnancy. MATERIAL AND METHODS: This is a prospective longitudinal study at 11 to 40 weeks of gestation of all singleton pregnancies followed in our fetal medicine unit during the period 2011-2015. Cervical length measurements were carried out by transvaginal ultrasound. Multilevel modeling was applied to establish cervical length reference ranges from 11 to 40 weeks...
September 16, 2016: Acta Obstetricia et Gynecologica Scandinavica
Camille Lallemant, Ditte Vassard, Anders Nyboe Andersen, Lone Schmidt, Nick Macklon
Over the last 30 years, a sustained decline in fertility rate in women has been observed as a result of delay in childbearing. This phenomenon, common to western societies, has been termed the 'postponement transition' and has implications not only for fertility, but for perinatal morbidity, child wellbeing and society in general (1). A number of factors have been proposed to account for the increasing trend to delay childbearing. These include improved educational and professional opportunities for women, care commitments, economic difficulties, absence of partner, and improved access to effective contraception (2, 3)...
September 16, 2016: Acta Obstetricia et Gynecologica Scandinavica
Nicole C M Visser, Ellen M Sparidaens, Jan-Willem van den Brink, Maria C Breijer, Erik A Boss, Sebastiaan Veersema, Albert G Siebers, Johan Bulten, Johanna M A Pijnenborg, Ruud L M Bekkers
INTRODUCTION: Women with postmenopausal bleeding and endometrial thickness >4 mm undergo endometrial sampling to exclude endometrial cancer. The aim of this study is to investigate the relative risk of developing endometrial cancer in a prospective cohort after initial work-up for postmenopausal bleeding showing reassuring histology or insufficient sampling. MATERIAL AND METHODS: All women presenting with postmenopausal bleeding were prospectively included from January 2009 to April 2011...
September 16, 2016: Acta Obstetricia et Gynecologica Scandinavica
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