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Acta Neurologica Scandinavica

Annette Baumgartner, Lars Frings, Florian Schiller, Oliver Stich, Michael Mix, Karl Egger, Gisa Schluh, Sebastian Rauer, Philipp T Meyer
OBJECTIVES: Although interferon-beta is an established drug for relapsing remitting multiple sclerosis (RRMS), its impact on neuronal activity is not well understood. METHODS: We investigated 15 patients with RRMS by [18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) to assess cerebral metabolic rate of glucose (CMRglc ) before interferon-beta therapy. Further, we performed clinical and neuropsychological investigations. In nine patients, these investigations were repeated after six months of therapy...
August 8, 2018: Acta Neurologica Scandinavica
Tatsuya Ueno, Haruo Nishijima, Hiroki Hikichi, Rie Haga, Akira Arai, Chieko Suzuki, Jin-Ichi Nunomura, Masahiko Tomiyama
BACKGROUND: Hyperthermia in patients with acute ischemic stroke is associated with poor outcome. Although previous studies have shown a negative effect on functional outcome, even in patients treated with intravenous recombinant tissue plasminogen activator (rt-PA), the effect on survival remains unclear. AIMS OF THE STUDY: The aim of this study was to evaluate the association between the functional and survival prognosis and hyperthermia in patients with acute ischemic stroke treated with rt-PA...
August 8, 2018: Acta Neurologica Scandinavica
Anne Christin Rahn, Sascha Köpke, Jan-Patrick Stellmann, Insa Schiffmann, Carsten Lukas, Declan Chard, Christoph Heesen
Magnetic resonance imaging (MRI) is the key prognostic tool in people with a clinically isolated syndrome (CIS). There is increasing interest in treating people following a CIS in the hope that conversion to multiple sclerosis (MS) will be prevented and future disability reduced. So far, the prognostic value of MRI for disability following a CIS has not been evaluated systematically. We systematically searched MEDLINE and EMBASE. Cohort studies were selected if they reported associations of MRI and disability following a CIS, included at least 50 people with a CIS at baseline, had at least 5 years of follow-up and obtained at least one structural MRI measurement (T1 lesions, T2 lesions, T1 contrast enhancing lesions or brain atrophy)...
August 8, 2018: Acta Neurologica Scandinavica
Ashalatha Radhakrishnan, Ramshekhar Menon, Sanjeev V Thomas, Mathew Abraham, George Vilanilam, Chandrashekharan Kesavadas, Bejoy Thomas, Ajith Cherian, Ravi Prasad Varma
OBJECTIVES: To explore the effect of duration of epilepsy and delay in surgery on seizure outcome in patients operated for drug-resistant temporal lobe epilepsy (TLE). MATERIALS & METHODS: 664 consecutive patients who underwent anterior temporal lobectomy (ATL) for TLE from 1995 to 2008 formed the study cohort. We divided them into two, one as seizure-free with or without antiepileptic drugs after ATL as "good outcome" (Engel Class I a) and seizures of any type, any time after surgery as "poor outcome"...
July 31, 2018: Acta Neurologica Scandinavica
Travis M Cruickshank, Alvaro P Reyes, Luis E Penailillo, Tim Pulverenti, Danielle M Bartlett, Pauline Zaenker, Anthony J Blazevich, Robert U Newton, Jennifer A Thompson, Johnny Lo, Mel R Ziman
OBJECTIVE: The primary objective of this trial was to evaluate the effects of outpatient multidisciplinary therapy, compared to usual care, on measures of physical function and muscle strength in patients with manifest Huntington's disease (HD). METHODS: Twenty-two patients with clinically verified HD were randomized to receive 36 weeks of outpatient multidisciplinary therapy or usual care. Outpatient multidisciplinary therapy comprised 9 months of supervised exercise, cognitive therapy and self-directed home-based exercise...
July 30, 2018: Acta Neurologica Scandinavica
Albert Puig-Pijoan, Eva Giralt-Steinhauer, Ana Zabalza de Torres, Rosa Maria Manero Borràs, Gonzalo Sánchez-Benavides, Greta García Escobar, Carmen Pérez Enríquez, Alejandra Gómez-González, Ángel Ois, Ana Rodríguez-Campello, Elisa Cuadrado-Godía, Jordi Jiménez-Conde, Jordi Peña-Casanova, Jaume Roquer
OBJECTIVES: Unilateral spatial neglect (USN) is the incapacity to respond to stimuli presented opposite to a dysfunctional cerebral hemisphere. It is usually caused by non-dominant hemisphere lesions, leads to poorer prognosis and might be underdiagnosed. The objectives of the study were to ascertain the presence of USN in acute stroke patients and analyze the possible degree of underdiagnosis in a Stroke Unit. MATERIALS AND METHODS: Prospective study of consecutive non-dominant hemisphere stroke patients within a period of 21 months...
July 30, 2018: Acta Neurologica Scandinavica
Kristian Varden Gjerde, Bernd Müller, Geir Olve Skeie, Jörg Assmus, Guido Alves, Ole-Bjørn Tysnes
OBJECTIVES: Olfactory dysfunction has been related to cognitive deficits in Parkinson's disease (PD), but evidence is conflicting and little is known about the relationship between these symptoms in early PD. Our objective was to study the association between smell deficits measured with a simple odor identification test at diagnosis of PD and the subsequent risk of cognitive decline. MATERIALS & METHODS: One hundred and ninety two PD patients from a population-based study were examined at time of diagnosis, before initiation of dopaminergic treatment, with follow-up of 177 patients after 3 years, 162 patients after 5 years and 146 patients after 7 years...
July 30, 2018: Acta Neurologica Scandinavica
Chantelle Murley, Fei Yang, Hanna Gyllensten, Kristina Alexanderson, Emilie Friberg
OBJECTIVES: The economic situation of individuals diagnosed with multiple sclerosis (MS) is under studied, with the levels and sources of incomes suggested to vary with socio-demographics. We aimed to describe the diversity of disposable income (DI) trajectories among working-aged individuals with incident MS, and investigate the associations of socio-demographic characteristics with identified trajectories. MATERIALS & METHODS: A population-based cohort study of all 1528 individuals first diagnosed with MS in 2008-2009 when aged 25-59, with data linked from three nationwide Swedish registers...
July 24, 2018: Acta Neurologica Scandinavica
Marzia A L Romeo, Vittorio Martinelli, Gloria Dalla Costa, Bruno Colombo, Donatella De Feo, Federica Esposito, Laura Ferrè, Clara Guaschino, Simone Guerrieri, Giuseppe Liberatore, Filippo Martinelli Boneschi, Arianna Merlini, Mariajosè Messina, Roberta Messina, Arturo Nuara, Paolo Preziosa, Marta Radaelli, Maria A Rocca, Mariaemma Rodegher, Francesca Sangalli, Davide Strambo, Lucia Moiola, Giancarlo Comi
OBJECTIVE: Within the last decade, many changes have been made to the management of patients with multiple sclerosis (MS). The aim of our study was to investigate the global impact of all these changes on the disease's course. MATERIALS AND METHODS: This single-centre study was carried out on patients with multiple sclerosis (pwMS) who started treatment with first-line disease-modifying therapies. We have compared three large cohorts of patients with MS diagnosis, for three consecutive periods within July 2001, August 2001-December 2005, and January 2006-September 2011...
July 22, 2018: Acta Neurologica Scandinavica
Brynhildur Hafsteinsdóttir, Elías Ólafsson, Finnbogi Jakobsson
OBJECTIVE: In this study, we determine the incidence and outcomes of Guillain-Barré syndrome (GBS) in Iceland over a 20-year period. METHOD: Cases were identified from the records of both referral hospitals in the country. All cases met the Brighton Criteria for GBS. Disability was assessed at diagnosis, peak of symptoms, discharge, and follow-up using the Guillain-Barré Disability Scale. RESULTS: Sixty-three individuals fulfilled the diagnostic criteria with an average age of onset of 46 years (range 1-89 years) and a male:female ratio of 1...
July 17, 2018: Acta Neurologica Scandinavica
Mário E T Dourado Júnior, Ugor T Fernandes, Eugênio S Ramos, Ana L F Vital, João C C Urbano, José W Queiroz, Selma M B Jeronimo
OBJECTIVE: The Erasmus Guillain Barre Outcome Score (EGOS) is a prognostic model that predicts the chance of being able to walk independently at 6 months after Guillain Barré syndrome (GBS). This study was conducted aiming to determine the validity of EGOS in a Brazilian population. MATERIAL AND METHODS: Data collected from GBS patients in Rio Grande do Norte, Brazil, were used to determine the validity of EGOS. GBS disability score was assessed in the second week of disease and at 6 months...
July 12, 2018: Acta Neurologica Scandinavica
Sawssan Ben Romdhan, Nouha Farhat, Amina Nasri, Suzanne Lesage, Olfa Hdiji, Mouna Ben Djebara, Zied Landoulsi, Giovanni Stevanin, Alexis Brice, Mariem Damak, Riadh Gouider, Chokri Mhiri
OBJECTIVES: The LRRK2-G2019S mutation is the most common cause of Parkinson's disease (PD) in North Africa. G2019S-PD has been described as similar to idiopathic with minor clinical differences. The aim of this study was to determine the G2019S-related phenotype and to investigate gender and gene dosage effects on clinical features of G2019S carriers. PATIENTS AND METHODS: The G2019S mutation was screened in 250 Tunisian patients with PD. Twenty-four patients carrying mutations in other PD genes were excluded...
July 10, 2018: Acta Neurologica Scandinavica
Hisako Fujiwara, Jeffrey Tenney, Darren S Kadis, Anna Byars, Mekibib Altaye, Caroline Spencer, Tracy Glauser, Jennifer Vannest
OBJECTIVES: The aim of this study was to understand the relationship between cortical morphology, centrotemporal spike (CTS), and neuropsychological functioning in children with BECTS compared to their typically developing peers. MATERIALS AND METHODS: To examine whole-brain differences in cortical thickness between groups, a general linear model approach was applied to T1-weighted structural magnetic resonance imaging (MRI) in children with BECTS and typically developing children...
July 10, 2018: Acta Neurologica Scandinavica
Yury V Gavrilov, Galina G Shkilnyuk, Philipp O Valko, Igor D Stolyarov, Elena V Ivashkova, Alexandr G Ilves, Irina G Nikiforova, Olga Y Shchelkova, Ludvig I Vasserman, Evelina E Vais, Yulia Valko
BACKGROUND: Fatigue is a common complaint in patients with multiple sclerosis (MS), and its detection and monitoring are based on self-reported questionnaires. The objective of this study was to validate the Russian translation of the Fatigue Impact Scale (FIS) and the Fatigue Severity Scale (FSS) in MS patients and controls. METHODS: We included 85 MS patients and 250 age-, sex-, and body mass index (BMI)-matched controls. We ascertained in all subjects levels of education, marital status, and comorbidities, such as sleepiness (using the Epworth Sleepiness Scale, ESS), anxiety and depression (using the Hospital Anxiety and Depression Scale, HADS)...
July 9, 2018: Acta Neurologica Scandinavica
Divya M Radhakrishnan, Bhargavi Ramanujam, Padma Srivastava, Deepa Dash, Manjari Tripathi
OBJECTIVE: The primary objective of present study was to observe the effect of providing SUDEP (Sudden Unexpected Death in Epilepsy) information on drug adherence in persons with epilepsy (PWE). We also looked at impact of disclosing SUDEP information on patient's quality of life and mood. MATERIAL AND METHODS: This prospective study had a pretest/post-test design. A total of 231 consecutive PWE (>15 years) were enrolled. Of these 121 PWE received information about SUDEP in addition to standard epilepsy care...
July 9, 2018: Acta Neurologica Scandinavica
A Candeliere Merlicco, L Gabaldón Torres, R Villaverde González, I Fernández Romero, E Aparicio Castro, M C Lastres Arias
OBJECTIVE: we aimed to evaluate the utility of transorbital ultrasonography (TOS) in optic nerve assessment and quantification of ON atrophy in MS patients, and to determine whether ON atrophy correlates with the disease duration and disability measured on the Kurtzke Expanded Disability Status Scale (EDSS). MATERIALS AND METHODS: Prospective, multicentre, blinded cohort study of 59 patients diagnosed with relapsing-remitting MS and 36 controls. RESULTS: When measured with TOS, the diameter of both the right (2...
July 2, 2018: Acta Neurologica Scandinavica
D Rackauskaite, E Svanborg, E Andersson, K Löwhagen, L Csajbok, B Nellgård
BACKGROUND: Patients with aneurysmal subarachnoid hemorrhage (aSAH) have poor outcome. Studies on outcome beyond 1 year post-aSAH are few, and late recovery is poorly investigated, initiating this prospective outcome study on patients 12-15 years after an aSAH. We hypothesized to find; functional improvement > 1 year post-ictus; increased long-term mortality in aSAH patients vs matched controls, and finally to present; predictors of long-term favorable outcome (GOS 4-5). METHODS: We prospectively investigated patients, admitted 2000-2003 to the Sahlgrenska University Hospital, 1 year post-ictus using Glasgow Outcome Scale (GOS)...
July 2, 2018: Acta Neurologica Scandinavica
K Herlofson, C J Heijnen, J Lange, G Alves, O-B Tysnes, J H Friedman, C P Fagundes
OBJECTIVES: Parkinson's disease (PD)-related fatigue is a significant clinical problem, and the pathological processes that cause fatigue remain unknown. The aim of the present study was to explore the possible association of peripheral inflammation markers and fatigue in PD. MATERIALS & METHODS: We included 47 drug naïve, newly diagnosed PD patients with low (≤3.0) or high (>5.5) fatigue levels as evaluated by the Fatigue Severity Scale (FSS). Strict diagnostic criteria were applied for inclusion...
June 26, 2018: Acta Neurologica Scandinavica
F A Scorza, A C Fiorini, A-C G de Almeida, C A Scorza, J Finsterer
No abstract text is available yet for this article.
June 21, 2018: Acta Neurologica Scandinavica
L Kadastik-Eerme, N Taba, T Asser, P Taba
No abstract text is available yet for this article.
June 21, 2018: Acta Neurologica Scandinavica
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