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Acta Neurologica Scandinavica

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https://www.readbyqxmd.com/read/28714112/wearables-in-epilepsy-and-parkinson-s-disease-a-focus-group-study
#1
A Ozanne, D Johansson, U Hällgren Graneheim, K Malmgren, F Bergquist, M Alt Murphy
OBJECTIVES: Wearable sensors that measure movement and physiological variables are attractive for clinical evaluation of neurological diseases such as epilepsy and Parkinson's disease (PD). The aim of this study was to explore perceptions regarding the use of wearable technology in disease monitoring and management as reported by individuals with epilepsy and Parkinson's disease as well as health professionals working with these patient groups. MATERIALS AND METHODS: Six patient groups (n=25) and two groups with health professionals (n=15) participated in this qualitative, descriptive study with focus group interviews...
July 16, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28677318/the-cost-utility-of-sodium-oxybate-as-narcolepsy-treatment
#2
K Bolin, P Berling, P Wasling, H Meinild, J Kjellberg, P Jennum
AIMS AND OBJECTIVES: Based on class-I studies, sodium oxybate is regarded as a first-line treatment for both EDS and cataplexy. The cost-effectiveness of sodium oxybate is largely unknown, though. In this study, we estimate the cost-effectiveness of sodium oxybate as treatment for patients with narcolepsy as compared to standard treatment, by calculating incremental cost-effectiveness ratios (cost per quality-adjusted life year, QALY) for patients in a Swedish setting. MATERIALS AND METHODS: Calculations were performed using a Markov model with a 10-year time horizon...
July 5, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28670681/gender-differences-in-parkinson-s-disease-a-clinical-perspective
#3
REVIEW
D Georgiev, K Hamberg, M Hariz, L Forsgren, G-M Hariz
Available data indicate that there are gender differences in many features of Parkinson's disease (PD). Precise identification of the gender differences is important to tailor treatment, predict outcomes, and meet other individual and social needs in women and men with PD. The aim of this study was to review the available clinical data on gender differences in PD. Original articles and meta-analyses published between 1990 and 2016 systematically exploring gender differences in PD were reviewed. There is slight male preponderance in incidence and prevalence of PD...
July 2, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28660733/prospective-measurement-of-quality-of-life-in-myotonic-dystrophy-type-1
#4
S Peric, C Heatwole, E Durovic, A Kacar, A Nikolic, I Basta, A Marjanovic, Z Stevic, D Lavrnic, V Rakocevic Stojanovic
INTRODUCTION: Generic patient reported outcome measures have had varied success in tracking QoL in myotonic dystrophy type 1 (DM1). AIM: To analyze changes of Individualized Neuromuscular Quality of Life questionnaire (INQoL) scores in clinic patients with DM1 over a 6-year period. METHOD: Patients completed the INQoL at baseline and after a 6-year period through their attendance in a neurology outpatient clinic. Severity of muscular involvement in DM1 was analyzed using the Muscular Impairment Rating Scale (MIRS)...
June 28, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28653396/parinaud-syndrome-any-clinicoradiological-correlation
#5
L Pollak, T Zehavi-Dorin, A Eyal, R Milo, R Huna-Baron
INTRODUCTION: The significance of MRI findings of patients with Parinaud syndrome (PS) with respect to clinical characteristics is poorly defined. Over the past decades, all patients with PS undergo magnetic resonance imaging which allows a better identification of the lesion localization. We compared the neuro-ophthalmological findings of patients with PS caused by intrinsic (intra-axial) vs extrinsic (pineal gland tumor) brainstem lesions. METHODS: Medical records of patients with PS evaluated between 2000 and 2016 were retrospectively reviewed...
June 26, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28653373/association-between-parkinson-s-disease-and-diabetes-data-from-nedices-study
#6
E De Pablo-Fernandez, F Sierra-Hidalgo, J Benito-León, F Bermejo-Pareja
BACKGROUND: Despite growing evidence showing an association between Parkinson's disease (PD) and diabetes, epidemiological studies have shown conflicting results. AIMS OF THE STUDY: To evaluate the association between PD and diabetes and the impact of diabetes duration in this association in an elderly (≥65 years) Spanish population. METHODS: Data for this cross-sectional population-based analysis were obtained from NEDICES study. Subjects were identified from census list...
June 26, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28626979/electro-clinical-criteria-and-surgical-outcome-is-there-a-difference-between-mesial-and-lesional-temporal-lobe-epilepsy
#7
M Wassenaar, F S S Leijten, G-J de Haan, S G Uijl, J W Sander
OBJECTIVES: Mesial temporal lobe epilepsy syndrome (MTLE) with specific electrophysiological and clinical characteristics and hippocampal sclerosis (HS) on MRI is considered the prototype of a syndrome with good surgical prognosis. Ictal onset zones in MTLE have been found to extend outside the hippocampus and neocortical seizures often involve mesial structures. It can, thus, be questioned whether MTLE with HS is different from lesional temporal epilepsies with respect to electro-clinical characteristics and surgical prognosis...
June 18, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28626907/controlled-population-based-comparative-study-of-usa-and-international-adult-55-74-neurological-deaths-1989-2014
#8
C Pritchard, E Rosenorn-Lanng, A Silk, L Hansen
OBJECTIVES: A population-based controlled study to determine whether adult (55-74 years) neurological disease deaths are continuing to rise and are there significant differences between America and the twenty developed countries 1989-91 and 2012-14. METHOD: Total Neurological Deaths (TND) rates contrasted against control Cancer and Circulatory Disease Deaths (CDD) extrapolated from WHO data. Confidence intervals compare USA and the other countries over the period...
June 18, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28613005/prognostic-role-of-hypochloremia-in-acute-ischemic-stroke-patients
#9
H-Z Bei, S-J You, D Zheng, C-K Zhong, H-P Du, Y Zhang, T-S Lu, L-D Cao, X-F Dong, Y-J Cao, C-F Liu
OBJECTIVES: The impact of electrolyte imbalance on clinical outcomes after acute ischemic stroke (AIS) is still not understood. We investigated the association between hypochloremia and hyponatremia upon hospital admission and in-hospital mortality in AIS patients. MATERIALS AND METHODS: A total of 3314 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city were included in this study. Hypochloremia was defined as having a serum chloride concentration <98 mmol/L and hyponatremia as having a serum sodium concentration <135 mmol/L...
June 14, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28612931/a-rating-scale-for-the-severity-of-guillain-barr%C3%A3-syndrome
#10
Z Guan, L Shang, W Zhang, Y Guo, Y Xue, X Li, Y Gong, X Liu
INTRODUCTION: The objective of this study was to develop a rating scale to assess the severity of Guillain-Barré syndrome (GBS). METHODS: The preliminary rating scale, which contained 11 items, was developed by the Delphi method, and data of 258 patients were collected to evaluate it. Item analysis was accomplished by 100 patients; the additional 158 patients were used to evaluate the reliability, validity, and discriminative ability of the rating scale. The structure of the rating scale was testified by the confirmatory factor analysis and also made a further evaluation by the correlation analysis...
June 14, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28608472/peripheral-neuropathy-in-30-duodopa-patients-with-vitamins-b-supplementation
#11
V Rispoli, V Simioni, J G Capone, N Golfrè Andreasi, F Preda, E Sette, V Tugnoli, M Sensi
OBJECTIVES: Peripheral neuropathy (PN) is a significant concern and potential cause of withdrawal in patients with Parkinson's disease (PD) treated with Levodopa/Carbidopa Intestinal Gel (LCIG) infusion. Vitamin B deficiency and/or hyperhomocysteinemia levodopa-related are considered possible causative factors. In this study, we evaluated PN incidence in LCIG-PD patients treated since the beginning of infusion with vitamins B supplementation. MATERIALS & METHODS: In this prospective open-label pilot study, 30 consecutive patients with PD on LCIG infusion were evaluated with clinical, neurophysiological, and biochemical assessments for a mean follow-up of 42...
June 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28608454/accelerated-atherosclerosis-in-anca-associated-vasculitis
#12
I González-Suárez, J J Ríos-Blanco, J Arpa
OBJECTIVES: Cardiovascular disease, including myocardial infarction and stroke, is a major cause of mortality in ANCA-associated vasculitis (AAV). Although AAV affects small vessels, an accelerated atherosclerosis not explained by traditional cardiovascular risk factors (CVRF) has been demonstrated. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cerebral small vessel disease in AAV-patients. MATERIALS & METHODS: Twenty-three AAV-patients in complete remission were recruited...
June 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28608406/pregnancy-in-cadasil
#13
I Donnini, V Rinnoci, S Nannucci, R Valenti, F Pescini, G Mariani, S Bianchi, M T Dotti, A Federico, D Inzitari, L Pantoni
OBJECTIVES: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral small vessel disease caused by NOTCH3 gene mutations. CADASIL women are frequently considered at high risk of systemic vascular events during pregnancy and often prescribed with antithrombotic drugs. This decision is not evidence-based considering the lack of data about pregnancy outcome in CADASIL. We describe our experience on pregnancy in CADASIL patients...
June 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28585316/patterns-of-antiepileptic-drug-prescription-in-sweden-a%C3%A2-register-based-approach
#14
K Bolin, F Berggren, P Berling, S Morberg, H Gauffin, A-M Landtblom
OBJECTIVES: To determine drug utilization pathways from the incident healthcare visit due to epilepsy and three years onward. MATERIAL AND METHODS: Anti-epileptic drug utilization was calculated using individual information on inpatient- and outpatient care utilization and drug sales. Throughout, we used national register information pertaining to pharmaceutical sales linked to diagnosis-related healthcare utilization. Information on pharmaceutical sales was collected for the 2007-2013 period...
June 5, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28573736/epilepsy-as-a-systemic-condition-link-with-somatic-comorbidities
#15
J Novy, G S Bell, J L Peacock, S M Sisodiya, J W Sander
BACKGROUND: People with epilepsy have more concomitant medical conditions than the general population; these comorbidities play an important role in premature mortality. We sought to generate explanatory hypotheses about the co-occurrence of somatic comorbidities and epilepsy, avoiding causal and treatment-resultant biases. METHODS: We collected clinical, demographic and somatic comorbidity data for 2016 consecutive adults with epilepsy undergoing assessment at a tertiary centre and in 1278 people with epilepsy in the community...
June 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28568478/behavioural-changes-in-patients-with-intellectual-disability-treated-with-perampanel
#16
E Andres, F Kerling, H Hamer, B Kasper, M Winterholler
OBJECTIVES: The aim of this cross-sectional retrospective study was to assess the tolerability and efficacy of perampanel in patients with drug-resistant epilepsy who also suffered from intellectual disability (ID). PATIENTS AND METHODS: We used an industry-independent, non-interventional retrospective evaluation based on standardized, daily seizure records. Twenty-seven patients with ID and drug-resistant epilepsy were started on perampanel between September 2012 and November 2015 after a 3-month observation period without perampanel treatment...
June 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28567742/transient-ischemic-attack-and-ischemic-stroke-patients-with-or-without-prior-stroke
#17
F Buchwald, B Norrving, J Petersson
OBJECTIVES: A history of stroke is common in patients with transient ischemic attack (TIA) and ischemic stroke (IS), but there are few reports characterizing this group of patients. We aimed to compare characteristics, risk factors, and secondary preventive treatment in patients with TIA or IS with vs without a history of stroke. METHODS: Hospital-based data on TIA and IS events, registered from July 2011 to June 2013, were obtained from the Swedish Stroke Register (Riksstroke)...
June 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28560798/vns-and-pregnancy-a-multicentric-experience-of-four-cases
#18
X Rodríguez-Osorio, F J López-González, Í Garamendi, J Rumià, A Matute, Á Prieto-González, M Carreño
BACKGROUND: Vagus nerve stimulation system (VNS) has been employed worldwide as adjunctive therapy in drug-resistant epileptic patients. Only nine previous pregnancies with six-positive outcomes have been reported in women with epilepsy treated with VNS since 1998. AIMS OF THE STUDY: To communicate the experience of pregnancies in women treated with VNS in our country. METHODS: Clinical data of four female patients treated with VNS during pregnancy and delivery in five gestations is described...
May 31, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28560774/role-of-p-glycoprotein-inhibitors-in-children-with-drug-resistant-epilepsy
#19
H A Elkhayat, R H Aly, I A Elagouza, R H El-Kabarity, Y I Galal
OBJECTIVE: The role of P-glycoprotein (Pgp), one of the known multidrug transporters, has been suggested in drug-resistant epilepsy (DRE). The following study aimed to measure the serum level of Pgp as a possible indicator of tissue Pgp overexpression in patients with DRE and to assess the efficacy of verapamil (as a Pgp inhibitor agent) in these patients. MATERIAL AND METHODS: A group of 24 patients with DRE were recruited and subdivided into two groups, one receiving verapamil and the other receiving a placebo in a double-blind randomized study...
May 31, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28560735/impact-of-the-swedish-national-stroke-campaign-on-stroke-awareness
#20
A Nordanstig, K Asplund, B Norrving, N Wahlgren, P Wester, L Rosengren
BACKGROUND: Time delay from stroke onset to arrival in hospital is an important obstacle to widespread reperfusion therapy. To increase knowledge about stroke, and potentially decrease this delay, a 27-month national public information campaign was carried out in Sweden. AIMS: To assess the effects of a national stroke campaign in Sweden. METHODS: The variables used to measure campaign effects were knowledge of the AKUT test [a Swedish equivalent of the FAST (Face-Arm-Speech-Time)] test and intent to call 112 (emergency telephone number) ...
May 31, 2017: Acta Neurologica Scandinavica
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