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Acta Neurologica Scandinavica

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https://www.readbyqxmd.com/read/28220473/risk-of-stroke-after-bereavement-a-systematic-literature-review
#1
REVIEW
F S Aalbaek, S Graff, M Vestergaard
Several studies have suggested that psychological stress may increase the risk of stroke. However, this link remains a controversial issue because of conflicting findings. Bereavement, the loss of a close relative, is considered a severely stressful life event. Increased risk of stroke could thus be expected after bereavement if stress plays a causal role. We aimed to evaluate the association between bereavement and stroke by performing a systematic review of the existing literature. The literature search was conducted according to the PRISMA guidelines for systematic reviews...
February 20, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28205227/impact-of-obstructive-sleep-apnea-on-neurological-recovery-after-ischemic-stroke-a-prospective-study
#2
D Menon, S Sukumaran, R Varma, A Radhakrishnan
OBJECTIVES: The presence of obstructive sleep apnea (OSA) has been found to adversely affect the neurological recovery after acute ischemic stroke (AIS) in previous observational studies. However, in most of these studies, diagnosis of OSA was based on oximetry data alone, raising concern in the accuracy of diagnosis as well as estimation of severity. Purpose of our study was to determine the prevalence and severity of OSA (based on polysomnography and American Association of Sleep Medicine [AASM] criteria) in patients with AIS and to compare the post-stroke neurological and functional outcome, in those with and without OSA...
February 15, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28185258/cerebrospinal-fluid-levels-of-chromogranin-a-and-phosphorylated-neurofilament-heavy-chain-are-elevated-in-amyotrophic-lateral-sclerosis
#3
M Kaiserova, Z Grambalova, P Otruba, D Stejskal, H Prikrylova Vranova, J Mares, K Mensikova, P Kanovsky
BACKGROUND: Various cerebrospinal fluid (CSF) biomarkers are being studied to improve the sensitivity and specificity of the diagnostic methods for amyotrophic lateral sclerosis (ALS). AIMS OF THE STUDY: The aim of our study was to establish the CSF levels of chromogranin A (CgA) and phosphorylated neurofilament heavy chain (pNF-H) in patients with ALS in order to assess these proteins as possible biomarkers of ALS. METHODS: Cerebrospinal fluid levels of CgA and pNF-H were examined and mutually compared in 15 patients with sporadic ALS and 16 gender- and age-matched controls...
February 10, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28181220/eslicarbazepine-acetate-as-adjunctive-therapy-in-clinical-practice-esladoba-study
#4
J Chaves, P Breia, J Pimentel, R Pelejão, M Carvalho, P Mateus, H Grebe, A Mestre, H Fernandes, R Sousa, A Gala
OBJECTIVE: To assess seizure control and tolerability of eslicarbazepine acetate (ESL) as adjunctive therapy to one baseline antiepileptic drug (AED), in adults with partial-onset seizures (POS) with or without secondary generalization. METHODS: Multicenter, non-interventional, prospective cohort study conducted between March 2012 and September 2014 at 12 neurology departments in Portugal. Adults with POS not controlled with one AED who had initiated ESL as adjunctive treatment were enrolled...
February 8, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28144933/hidden-in-plain-sight-non-convulsive-status-epilepticus-recognition-and-management
#5
REVIEW
M O Kinney, J J Craig, P W Kaplan
Non-convulsive status epilepticus (NCSE) is an electroclinical state associated with an altered level of consciousness but lacking convulsive motor activity. It can present in a multitude of ways, but classification based on the clinical presentation and electroencephalographic appearances assists in determining prognosis and planning treatment. The aggressiveness of treatment should be based on the likely prognosis and the underlying cause of the NCSE.
February 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28133726/algorithms-for-the-treatment-of-motor-problems-in-parkinson-s-disease
#6
REVIEW
E Dietrichs, P Odin
Several different strategies are effective for medical treatment of motor problems in Parkinson's disease (PD). Many guidelines and evidence-based reviews are available, but there is no documentation or consensus in favor of just one treatment strategy. This review presents two algorithms that may be helpful when deciding how to treat a PD patient at various stages of the disease. The first algorithm suggests one way to treat PD from the first onset of motor symptoms. It is largely based on treatment recommendations from the Scandinavian countries and Germany...
January 30, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28127776/the-prognosis-of-stroke-survivors-primarily-discharged-to-their-homes
#7
S M Mathisen, J P Larsen, M W Kurz
OBJECTIVES: Stroke is one of the leading causes for nursing home placement (NHP). We have studied the prognosis and risk factors regarding NHP for stroke patients initially discharged to their homes. MATERIALS AND METHODS: All stroke patients in the municipality of Stavanger, Norway, between January 1, 1996, and March 31, 2004, were included and followed until death or May 31, 2012. Time intervals for NHP and death were compared to an age- and sex-matched, stroke-free control cohort...
January 27, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28093722/triptan-use-in-australia-1997-2015-a-pharmacoepidemiological-study
#8
B L K D Eyre, M J Eadie, M L van Driel, L Ross-Lee, S A Hollingworth
OBJECTIVE: This study examined the use of triptan derivatives in Australia between 1997 and 2015, based on a national drug reimbursement database, and compared patterns of use with available international data. METHODS: We obtained publically available data on the number of prescriptions for triptans marketed in Australia (sumatriptan, eletriptan, rizatriptan, zolmitriptan, naratriptan). Dispensed use was measured as defined daily dose (DDD per 1000 population per day) for Australia's concessional beneficiaries (low-income earners, people with disabilities, and seniors)...
January 16, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28090629/what-is-the-l-in-lpds-localized-as-well-as-lateralized
#9
E Hartl, J Rémi, C Stoyke, S Noachtar
BACKGROUND: Periodic discharges (PDs) are well established as either periodic lateralized epileptiform discharges (LPDs) or generalized discharges. However, PDs in the midline can currently not be adequately classified as they are not generalized and not lateralized. AIMS OF THE STUDY: To propose a modification of the current LPD classification. METHODS: We here present a paradigmatic case series of three adult patients with midline LPDs. RESULTS: In our patients, ictal electroencephalography (EEG) recordings revealed periodic epileptiform discharges in the midline region...
January 16, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28083960/quality-of-life-perception-by-parkinson-s-disease-patients-and-caregivers
#10
Y Balash, A D Korczyn, J Knaani, A A Migirov, T Gurevich
BACKGROUND: The quality-of-life (QoL) perception by Parkinson's disease (PD) patients and their caregivers (CG) has not been studied in depth. OBJECTIVE: To examine patient/proxy agreements on the PD QoL Questionnaire (PDQ-39), the Scale of Quality of Life of Care-Givers (SQLC) and the Multidimensional Caregiver Strain Index (MCSI). METHODS: Patients with PD and their CG completed the above-mentioned questionnaires about themselves and each other...
January 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28070886/spinal-cord-atrophy-in-anterior-posterior-direction-reflects-impairment-in-multiple-sclerosis
#11
H Lundell, O Svolgaard, A-M Dogonowski, J Romme Christensen, F Selleberg, P Soelberg Sørensen, M Blinkenberg, H R Siebner, E Garde
OBJECTIVE: To investigate how atrophy is distributed over the cross section of the upper cervical spinal cord and how this relates to functional impairment in multiple sclerosis (MS). METHODS: We analysed the structural brain MRI scans of 54 patients with relapsing-remitting MS (n=22), primary progressive MS (n=9), secondary progressive MS (n=23) and 23 age- and sex-matched healthy controls. We measured the cross-sectional area (CSA), left-right width (LRW) and anterior-posterior width (APW) of the spinal cord at the segmental level C2...
January 10, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28052315/deficits-in-temporal-processing-correlate-with-clinical-progression-in-huntington-s-disease
#12
P V Agostino, E M Gatto, M Cesarini, J L Etcheverry, A Sanguinetti, D A Golombek
OBJECTIVES: Precise temporal performance is crucial for several complex tasks. Time estimation in the second-to-minutes range-known as interval timing-involves the interaction of the basal ganglia and the prefrontal cortex via dopaminergic-glutamatergic pathways. Patients with Huntington's disease (HD) present deficits in cognitive and motor functions that require fine control of temporal processing. The objective of the present work was to assess temporal cognition through a peak-interval time (PI) production task in patients with HD and its potential correlation with the Unified Huntington's Disease Rating Scale (UHDRS)...
January 3, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28032330/cerebrospinal-fluid-cytotoxicity-does-not-affect-survival-in-amyotrophic-lateral-sclerosis
#13
L Galán, J Matías-Guiu, J A Matias-Guiu, M Yáñez, V Pytel, A Guerrero-Sola, A Vela-Souto, J A Arranz-Tagarro, U Gómez-Pinedo, A G García
OBJECTIVES: Cerebrospinal fluid (CSF) from some patients with amyotrophic lateral sclerosis (ALS) has been demonstrated to significantly reduce the neuronal viability of primary cell cultures of motor neurons. We aimed to study the potential clinical consequences associated with the cytotoxicity of CSF in a cohort of patients with ALS. METHODS: We collected CSF from thirty-one patients with ALS. We analysed cytotoxicity by incubating it into the primary cultures of motor cortex neurons...
December 29, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28028820/risk-factors-for-mortality-in-patients-with-anti-nmda-receptor-encephalitis
#14
X Chi, W Wang, C Huang, M Wu, L Zhang, J Li, D Zhou
OBJECTIVE: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune disorder with a mortality of 5%-7%, but few studies have focused on the predictors of death in this disease. In this study, we aim to investigate predictors and causes of death in patients with anti-NMDAR encephalitis. METHODS: In this cohort study, patients with anti-NMDAR encephalitis were enrolled at the West China Hospital of Sichuan University between June 2011 and October 2015...
December 27, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28028819/a-pilot-randomized-controlled-trial-comparing-effectiveness-of-prism-glasses-visual-search-training-and-standard-care-in-hemianopia
#15
F J Rowe, E J Conroy, E Bedson, E Cwiklinski, A Drummond, M García-Fiñana, C Howard, A Pollock, T Shipman, C Dodridge, C MacIntosh, S Johnson, C Noonan, G Barton, C Sackley
OBJECTIVE: Pilot trial to compare prism therapy and visual search training, for homonymous hemianopia, to standard care (information only). METHODS: Prospective, multicentre, parallel, single-blind, three-arm RCT across fifteen UK acute stroke units. PARTICIPANTS: Stroke survivors with homonymous hemianopia. INTERVENTIONS: Arm a (Fresnel prisms) for minimum 2 hours, 5 days per week over 6 weeks. Arm b (visual search training) for minimum 30 minutes, 5 days per week over 6 weeks...
December 27, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28026006/extended-eeg-and-non-convulsive-status-epilepticus-benefit-over-routine-eeg
#16
E Eskioglou, C Stähli, A O Rossetti, J Novy
OBJECTIVE: EEG monitoring is increasingly used in critically ill patients, but impact on clinical outcome remains unclear. We aimed to investigate the benefit of repeated extended EEG in the prognosis of patients with non-convulsive status epilepticus (SE). MATERIALS & METHODS: We retrospectively collected 29 consecutive patients with non-convulsive SE without coma, who underwent repeated extended EEG between 2013 and 2015. We compared these patients with an historical age-matched group of 58 patients managed between 2011 and 2013 with routine EEG only...
December 27, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28025828/prognostic-parameters-and-outcome-after-re-irradiation-for-progressive-glioblastoma
#17
K Zwirner, F Paulsen, J Schittenhelm, C Borchers, M Skardelly, D Zips, F Eckert
OBJECTIVES: In progressive glioblastoma, salvage treatment remains unstandardized, response is highly variable, and detailed analysis of individual approaches is mandatory. Re-irradiation is an established option in the therapy of progressive glioblastoma. Thus, we analysed outcome and prognostic parameters of patients with re-irradiated glioblastoma treated at our institution since 1998. MATERIALS AND METHODS: In a total of 51 patients, clinical and treatment parameters were collected and analysed retrospectively...
December 26, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28025821/identifying-patients-at-risk-of-acute-symptomatic-seizure-after-ischemic-stroke
#18
K N Alme, B A Engelsen, M Naik, H Naess
BACKGROUND: Contributors to post-stroke seizure research have advocated the need for prospective studies of acute symptomatic seizures after stroke. Identification of the patient at risk of seizure and the impact of the event on outcome is a prerequisite for this kind of research. The aim of this study was to identify risk factors, make an outline for a risk score, and look at consequences of seizure on short-time clinical outcomes. METHODS: This registry-based study included patients with ischemic stroke admitted between 2007 and 2013...
December 26, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28008594/causes-of-death-in-critically-ill-multiple-sclerosis-patients
#19
A Karamyan, H Brandtner, S Grinzinger, V Chroust, C Bacher, F Otto, M Reisp, L Hauer, J Sellner
BACKGROUND: Patients with multiple sclerosis (MS) experience higher mortality rates as compared to the general population. While the risk of intensive care unit (ICU) admission is also reported to be higher, little is known about causes of death CoD in critically ill MS patients. AIM: To study the causes of death (CoD) in the series of critically ill patients with MS verified by autopsy. METHODS: We reviewed hospital electronic charts of MS patients treated at the neurological ICU of a tertiary care hospital between 2000 and 2015...
December 23, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27976804/a-longitudinal-real-life-comparison-study-of-natalizumab-and-fingolimod
#20
R Lanzillo, A Carotenuto, M Moccia, F Saccà, C V Russo, M Massarelli, A De Rosa, V Brescia Morra
BACKGROUND: Different retrospective studies compared natalizumab and fingolimod in relapsing-remitting multiple sclerosis (RRMS), with conflicting results. We aimed to explore the prescriptive attitude and the clinical outcome of the two therapies. METHODS: We retrospectively included all RRMS patients treated with natalizumab (n=101) or fingolimod (n=78) as their first second-line therapy with at least 24-month follow-up. Demographic and clinical features were recorded to calculate the propensity score (PS)...
December 15, 2016: Acta Neurologica Scandinavica
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