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Acta Neurologica Scandinavica

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https://www.readbyqxmd.com/read/27891575/multiple-sclerosis-impact-on-employment-and-income-in-new-zealand
#1
J F Pearson, S Alla, G Clarke, D F Mason, T Anderson, A Richardson, D H Miller, C E Sabel, D A Abernethy, E W Willoughby, B V Taylor
BACKGROUND AND OBJECTIVES: We investigated the demographic, social and clinical characteristics associated with employment status and income for people with multiple sclerosis (MS) in New Zealand (NZ). METHODS: The NZ National MS Prevalence study included all persons resident in NZ on census day 2006 diagnosed with MS (96.7% coverage). Factors associated with employment and income status among the working age population (25-64 years) were identified by linear regression...
November 28, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27891572/safety-concerns-and-risk-management-of-multiple-sclerosis-therapies
#2
REVIEW
P Soelberg Sorensen
Currently, more than ten drugs have been approved for treatment of relapsing-remitting multiple sclerosis (MS). Newer treatments may be more effective, but have less favorable safety record. Interferon-β preparations and glatiramer acetate treatment require frequent subcutaneous or intramuscular injections and are only moderately effective, but have very rarely life-threatening adverse effects, whereas teriflunomide and dimethyl fumarate are administered orally and have equal or better efficacy, but have more potentially severe adverse effects...
November 27, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27858953/the-concept-and-diagnostic-criteria-of-primary-lateral-sclerosis
#3
Verena Wais, Angela Rosenbohm, Susanne Petri, Katja Kollewe, Andreas Hermann, Alexander Storch, Frank Hanisch, Stephan Zierz, Gabriele Nagel, Jan Kassubek, Patrick Weydt, Johannes Brettschneider, Jochen H Weishaupt, Albert C Ludolph, Johannes Dorst
OBJECTIVES: Primary lateral sclerosis (PLS) is commonly considered as a motor neuron disease (MND) variant which almost exclusively affects upper motor neurons (UMN). There is still no consensus whether PLS should be regarded as an independent disease entity separate from amyotrophic lateral sclerosis (ALS) or as a comparatively slowly progressive variant of ALS. Given these different views, clinical diagnosis of PLS is a challenge. In this multicenter study, we analyzed clinical features of patients diagnosed with PLS in four specialized MND centers...
November 15, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27861722/epilepsy-and-adverse-quality-of-life-in-surgically-resected-meningioma
#4
M J Tanti, A G Marson, M D Jenkinson
OBJECTIVES: Meningiomas are common intracranial tumors, and despite surgery or therapy with anti-epileptic drugs (AEDs), many patients suffer from seizures. Epilepsy has a significant impact on quality of life (QoL) in non-tumor populations, but the impact of epilepsy on QoL in patients with meningioma is unknown. Our aim was to evaluate the impact of epilepsy on QoL in patients that have undergone resection of a benign meningioma. MATERIALS AND METHODS: We recruited meningioma patients without epilepsy (n=109), meningioma patients with epilepsy (n=56), and epilepsy patients without meningioma (n=64)...
November 14, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27861715/the-value-of-the-bulbocavernosus-reflex-and-pudendal-nerve-somatosensory-evoked-potentials-in-distinguishing-between-multiple-system-atrophy-and-parkinson-s-disease-at-an-early-stage
#5
Z-Y Cai, X-T Niu, J Pan, P-Q Ni, X Wang, B Shao
OBJECTIVES: This study was designed to investigate the clinical value of the bulbocavernosus reflex (BCR) and pudendal nerve somatosensory evoked potentials (PSEPs) in the differential diagnosis between multiple system atrophy (MSA) and Parkinson's disease (PD) in early stage. MATERIALS AND METHODS: A total of 31 patients with MSA, 45 patients with PD, and 60 healthy participants were included in this study. A Keypoint EMG/EP system was used for BCR and PSEP measurements...
November 10, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27808417/lack-of-efficacy-of-levetiracetam-in-oromandibular-and-cranial-dystonia
#6
J E Park, P Srivanitchapoom, C W Maurer, P Mathew, J Sackett, R Paine, V L Ramos, M Hallett
OBJECTIVE: To determine the efficacy of levetiracetam in oromandibular or cranial dystonia. METHODS: We recruited seven subjects with oromandibular or cranial dystonia. Five completed the study, median age was 71 years (range 42-79 years), median disease duration was 12 years (range 2-30 years). Participants were randomized to receive levetiracetam or placebo and were then crossed over. They titrated up to a total daily dose of 4000 mg or the maximum tolerated dose over 3 weeks and maintained that dose for another 3 weeks...
November 3, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27804118/elevated-levels-of-ferritin-in-the-cerebrospinal-fluid-of-amyotrophic-lateral-sclerosis-patients
#7
Y Zheng, L Gao, D Wang, D Zang
OBJECTIVES: The aim of the study was to detect changes in the levels of ferritin heavy chain (FHC), ferritin light chain (FLC), and transferrin in the cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients and to analyze the correlations between the levels of these proteins and various clinical parameters. METHODS: Cerebrospinal fluid and serum samples were obtained from 54 ALS patients and 46 non-inflammatory neurological disease control (non-INDC) patients...
November 1, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27804110/cognitive-function-in-stroke-survivors-a-10-year-follow-up-study
#8
H Delavaran, A-C Jönsson, H Lövkvist, S Iwarsson, S Elmståhl, B Norrving, A Lindgren
OBJECTIVES: Post-stroke cognitive impairment (PSCI) has considerable impact on patients and society. However, long-term studies on PSCI are scarce and may be influenced by assessment methods and selection bias. We aimed to (i) assess the prevalence of long-term PSCI; (ii) compare two common cognitive assessment instruments; and (iii) compare cognitive function of long-term stroke survivors with non-stroke persons. METHODS: Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were administered to 10-year survivors from a population-based cohort of first-ever stroke patients included in the Lund Stroke Register, Sweden, in 2001-2002...
November 1, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27796033/baseline-predictors-of-persistence-to-first-disease-modifying-treatment-in-multiple-sclerosis
#9
U K Zettl, H Schreiber, U Bauer-Steinhusen, T Glaser, K Hechenbichler, M Hecker
OBJECTIVES: Patients with multiple sclerosis (MS) require lifelong therapy. However, success of disease-modifying therapies is dependent on patients' persistence and adherence to treatment schedules. In the setting of a large multicenter observational study, we aimed at assessing multiple parameters for their predictive power with respect to discontinuation of therapy. MATERIALS AND METHODS: We analyzed 13 parameters to predict discontinuation of interferon beta-1b treatment during a 2-year follow-up period based on data from 395 patients with MS who were treatment-naïve at study onset...
October 30, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27790700/cognitive-deterioration-in-adult-epilepsy-clinical-characteristics-of-accelerated-cognitive-ageing
#10
L E M Breuer, E Grevers, P Boon, A Bernas, J W M Bergmans, R M H Besseling, D C W Klooster, A de Louw, R M C Mestrom, K Vonck, S Zinger, A P Aldenkamp
OBJECTIVES: "Epileptic dementia" is reported in adults with childhood-onset refractory epilepsy. Cognitive deterioration can also occur in a "second-hit model". MATERIALS AND METHODS: We studied the clinical and neuropsychological characteristics of patients with cognitive deterioration (≥1 SD discrepancy between current IQ and premorbid IQ). Memory function, reaction time and processing speed were also evaluated. Analyses were performed to investigate which clinical characteristics correlated with cognitive deterioration...
October 28, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27781263/a-review-of-medication-adherence-in-people-with-epilepsy
#11
REVIEW
N Malek, C A Heath, J Greene
People with epilepsy (PWE) have a higher risk of mortality in comparison with the general population. This in part reflects intrinsic factors or associated comorbidities, but poor adherence to anti-epileptic drugs (AED) has also been shown to contribute to increased risk of death and increased utilization of unscheduled care. The aim of this review was to determine the prevalence of non-adherence to AED in PWE, evaluate whether specific clinical and demographic features can allow clinicians to identify those at highest risk and identify the methods and techniques that can be used to improve adherence in clinical settings...
October 26, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27781262/risk-of-parkinson-disease-after-organophosphate-or-carbamate-poisoning
#12
C-S Chuang, H-L Su, C-L Lin, C-H Kao
AIMS: Parkinson disease (PD) is a common neurodegenerative disease. The aim of this study was to evaluate the risk of PD in patients with organophosphate (OP) or carbamate (CM) poisoning by using the Taiwan National Health Insurance Research Database. METHODS: We conducted a retrospective study involving a cohort of 45 594 patients (9128 patients with a history of OP or CM poisoning and 36 466 control patients) who were selected from the Taiwan National Health Insurance Research Database...
October 26, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27781261/psychometric-properties-of-the-mutuality-scale-in-swedish-dyads-with-parkinson-s-disease
#13
M Karlstedt, S M Fereshtehnejad, E Winnberg, D Aarsland, J Lökk
OBJECTIVES: The 15-item mutuality scale (MS) has been used in several neurological conditions assessing the quality of relationship associations with negative effects of the caregiving situation. The aim of this study was to translate the original MS into Swedish and assess its psychometric properties in Parkinson's disease (PD). MATERIALS AND METHODS: Following the forward-backward translation method, the scale was evaluated regarding linguistic correctness at a conceptual level and user-friendliness...
October 26, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27778334/cognitive-impairment-and-magnetic-resonance-imaging-correlates-in-primary-progressive-multiple-sclerosis
#14
A Gouveia, S P Dias, T Santos, H Rocha, C R Coelho, L Ruano, O Galego, M C Diogo, D Seixas, M J Sá, S Batista
OBJECTIVES: To characterize cognitive impairment in primary progressive multiple sclerosis (PPMS) and to correlate the pattern of cognitive deficits with brain magnetic resonance imaging (MRI) volumetric data. MATERIALS AND METHODS: In a multicenter cross-sectional study, we recruited consecutive patients with PPMS as well as age, sex, and education level-matched healthy controls (HC). All participants underwent neuropsychological (NP) assessment, and brain MRI was performed in patients with PPMS for analysis of lesion load, subcortical GM volumes, and regional cortical volumes...
October 24, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27766611/jcv-serology-in-time-3%C3%A2-years-of-follow-up
#15
M Cambron, N Hadhoum, E Duhin, A Lacour, A Chouraki, P Vermersch
OBJECTIVES: Although many neurologists are reluctant to use natalizumab in MS (multiple sclerosis) given the increased risk for PML (progressive multifocal leukoencephalopathy), trust was regained with the introduction of JCV antibody titres as a potent disease-modifying therapy. Literature shows that in patients with a negative JCV serology, the risk of PML is virtually non-existent. Unfortunately, seroconversion causes concern amongst many neurologists. Furthermore, when patients seroconvert, it is still unclear what the risk is of passing the important threshold of 1...
October 20, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27757951/efficacy-and-tolerability-of-anti-epileptic-drugs-an-internet-study
#16
U C Wieshmann, G Baker
OBJECTIVE: To ascertain efficacy and tolerability of carbamazepine (CBZ), sodium valproate (VPA), lamotrigine (LTG) and levetiracetam (LEV) using the UKAED register (www.ukaed.info). METHODS: Patients on CBZ (n=91), VPA (n=61), LTG (n=105), LEV (n=72) and healthy control subjects (CTR) on no medication (n=51) were extracted. All patients had anonymously provided information on seizure type and frequency and completed the Liverpool Adverse Event Profile (LAEP). RESULTS: The number of seizure-free patients in the last 4 weeks was overall CBZ/VPA/LTG/LEV=60%/79%/67%/67%, for generalized epilepsy was CBZ/VPA/LTG/LEV=67%/89%/65%/94%, and for localization-related epilepsy was CBZ/VPA/LTG/LEV=59%/71%/67%/57%...
October 18, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27726132/factors-associated-with-life-satisfaction-in-parkinson-s-disease
#17
K Rosqvist, P Hagell, P Odin, H Ekström, S Iwarsson, M H Nilsson
OBJECTIVES: To identify factors associated with life satisfaction (LS) in people with Parkinson's disease (PD), including a specific focus on those with late-stage PD. MATERIAL AND METHODS: The study included 251 persons with PD (median age 70 years; PD duration 8 years). Analyses involved the total sample and a subsample with late-stage PD, that is Hoehn and Yahr stages IV and V (n=62). LS was assessed with item 1 of the Life Satisfaction Questionnaire (LiSat-11)...
October 10, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27726128/parkinson-s-disease-in-germany-prevalence-and-incidence-based-on-health-claims-data
#18
M Nerius, A Fink, G Doblhammer
BACKGROUND: In Germany, epidemiological information on Parkinson's disease (PD) is rare and outdated. Considering aging populations, current prevalences and incidence rates about this age-related disease would be important for adequate public health planning. METHODS: We used newly available health claims data sets from the largest German health insurer dating 2004-2007 and 2007-2010 with an analysis population in the base years of 491 038 persons aged 50 and older...
October 10, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27726124/primary-familial-brain-calcification-linked-to-deletion-of-5-noncoding-region-of-slc20a2
#19
P Pasanen, J Mäkinen, L Myllykangas, R Guerreiro, J Bras, M Valori, M Viitanen, M Baumann, P J Tienari, M Pöyhönen, P Baumann
OBJECTIVES: Primary familial brain calcification (PFBC) is a rare neurological disease often inherited as a dominant trait. Mutations in four genes (SLC20A2, PDGFB, PDGFRB, and XPR1) have been reported in patients with PFBC. Of these, point mutations or small deletions in SLC20A2 are most common. Thus far, only one large deletion covering entire SLC20A2 and several smaller, exonic deletions of SLC20A2 have been reported. The aim of this study was to identify the causative gene defect in a Finnish PFBC family with three affected patients...
October 10, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27714769/lacosamide-and-sodium-channel-blocking-antiepileptic-drug-cross-titration-against-levetiracetam-background-therapy
#20
M Baulac, W Byrnes, P Williams, S Borghs, E Webster, M De Backer, P Dedeken
OBJECTIVE: To assess prospectively the effectiveness of lacosamide (LCM) added to levetiracetam (LEV) after down-titration of a concomitant sodium channel blocker (SCB) among patients with focal epilepsy not adequately controlled on LEV and SCB. METHODS: In this open-label trial, LCM was initiated at 100 mg/day and up-titrated to 200-600 mg/day over 9 weeks; SCB down-titration started when LCM dose reached 200 mg/day. Patients remained on stable LCM/LEV doses for 12 weeks' maintenance (21-week treatment period)...
October 6, 2016: Acta Neurologica Scandinavica
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