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Acta Neurologica Scandinavica

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https://www.readbyqxmd.com/read/28436001/gait-instability-in-valproate-treated-patients-call-to-measure-ammonia-levels
#1
S Kipervasser, C E Elger, A D Korczyn, R D Nass, C M Quesada, M Y Neufeld
OBJECTIVE: Hyperammonemia induced by valproate (VPA) treatment may lead to several neurological and systemic symptoms as well as to seizure exacerbation. Gait instability and recurrent falls are rarely mentioned as symptoms, especially not as predominant ones. METHODS: We report five adult patients with frontal lobe epilepsy (FLE) who were treated with VPA and in whom a primary adverse effect was unstable gait and falls. RESULTS: There were four males and one female patients with FLE, 25-42-year-old, three following epilepsy surgery...
April 23, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28417454/prevalence-and-predictors-of-anxiety-in-an-african-sample-of-recent-stroke-survivors
#2
A Ojagbemi, M Owolabi, R Akinyemi, O Arulogun, J Akinyemi, O Akpa, F S Sarfo, E Uvere, R Saulson, S Hurst, B Ovbiagele
OBJECTIVES: Studies considering emotional disturbances in the setting of stroke have primarily focused on depression and been conducted in high-income countries. Anxiety in stroke survivors, which may be associated with its own unique sets of risk factors and clinical parameters, has been rarely investigated in sub-Saharan Africa (SSA). We assess the characteristics of anxiety and anxiety-depression comorbidity in a SSA sample of recent stroke survivors. MATERIALS AND METHODS: We assessed baseline data being collected as part of an intervention to improve one-year blood pressure control among recent (≤1 month) stroke survivors in SSA...
April 17, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28393354/discrepancy-in-prevalence-of-huntington-s-disease-in-two-swedish-regions
#3
A-K Roos, L Wiklund, K Laurell
BACKGROUND: Huntington's disease (HD) is a neurodegenerative disease with an autosomal dominant pattern of inheritance. The prevalence varies between different geographical regions with an estimated average in Europe of about 6/100 000. Parts of northern Sweden are known to have an accumulation of HD, but no prevalence studies have been undertaken for 50 years. OBJECT: The aim of this study was to estimate the prevalence of HD in the two different Swedish counties of Jämtland and Uppsala and compare them with the reported prevalence in Europe...
April 9, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28393349/multiple-biomarkers-improve-the-prediction-of-multiple-sclerosis-in-clinically-isolated-syndromes
#4
V Martinelli, G Dalla Costa, M J Messina, G Di Maggio, F Sangalli, L Moiola, M Rodegher, B Colombo, R Furlan, L Leocani, A Falini, G Comi
OBJECTIVES: Since its introduction, MRI had a major impact on the early and more precise diagnosis of multiple sclerosis (MS), and the 2010 diagnostic criteria even allow a diagnosis to be made just after a single attack if stringent MRI criteria are met. Several other clinical and paraclinical markers have been reported to be associated with an increased risk of MS independently of MRI in patients with clinically isolated syndromes (CIS), but the incremental usefulness of adding them to the current criteria has not been evaluated...
April 9, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28393348/housing-accessibility-problems-for-people-with-parkinson-s-disease
#5
B Slaug, S Iwarsson, J A Ayala, M H Nilsson
OBJECTIVES: Promoting accessible housing for all citizens is high on the political agenda. Knowledge is, however, limited regarding housing accessibility problems for people with Parkinson's disease (PD). The objectives were to investigate housing accessibility problems among people with PD at different stages of disease severity and to analyze the potential impact of improved functional ability on accessibility problems. MATERIALS AND METHODS: The study included 253 participants with PD (61% men; mean age 70 years)...
April 9, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28382656/surgery-for-chronic-subdural-hematoma-in-nonagenarians-a-scandinavian-population-based-multicenter-study
#6
J Bartek, K Sjåvik, F Ståhl, H Kristiansson, O Solheim, S Gulati, L M Sagberg, P Förander, A S Jakola
OBJECTIVE: Chronic subdural hematoma (cSDH) is a prevalent condition often seen in the elderly, with surgery being the treatment of choice when symptomatic. So far, few have explored the surgical outcomes in patients 90 years or older. The aim of this study was to investigate outcome after cSDH surgery in nonagenarians (≥90 y/o group) compared to younger adult patients (<90 y/o group). MATERIALS: In a Scandinavian population-based cohort we conducted a retrospective review of 1,254 patients undergoing primary burr-hole procedures for cSDH between January 1, 2005 and December 31, 2010 at three neurosurgical centers...
April 6, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28369734/predictors-of-successful-primary-care-detoxification-treatment-for-medication-overuse-headache
#7
E S Kristoffersen, J Straand, J Š Benth, M B Russell, C Lundqvist
OBJECTIVES: To investigate predictors for successful treatment outcome after a brief intervention (BI) for medication-overuse headache (MOH). MATERIALS AND METHODS: This study evaluated predictors of successful withdrawal among patients initially participating in a pragmatic cluster-randomized controlled trial with single crossover in Norwegian general practice (the BIMOH study). BI (early or after crossover) was compared to business as usual (BAU) for the treatment of MOH...
March 28, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28345787/non-motor-symptoms-and-quality-of-life-in-subjects-with-mild-parkinsonian-signs
#8
J Prasuhn, L Piskol, E-J Vollstedt, J Graf, A Schmidt, V Tadic, S Tunc, J Hampf, E Warrlich, C Bibergeil, J Hagenah, C Klein, M Kasten, N Brüggemann
BACKGROUND: Mild parkinsonian signs (MPS) are frequent in the elderly population and associated with the presence of risk markers for Parkinson's disease (PD). Both MPS and non-motor signs may be present in prodromal PD and may significantly impair quality of life (QoL). OBJECTIVE: To disentangle the contribution of motor impairment and extra-motor manifestations to QoL in subjects with MPS (n=63), manifest PD (n=69), disorders with motor symptoms due to non-neurodegenerative diseases (n=213) and healthy controls (n=258)...
March 27, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28321835/teriflunomide-for-multiple-sclerosis-in-real-world-setting
#9
M L Elkjaer, T Molnar, Z Illes
OBJECTIVES: Teriflunomide 14 mg is a once-daily oral disease-modifying treatment for relapsing-remitting multiple sclerosis. We examined adverse event (AE) profile and efficacy in real life. MATERIALS AND METHODS: In this observational cohort study, we retrospectively examined 1521 blood samples and data of 102 patients followed for up to 28 months. RESULTS: The number of female patients starting teriflunomide peaked in the fifth decade, 10 years later compared to male patients (P<...
March 20, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28299787/first-clinical-experience-with-levodopa-carbidopa-microtablets-in-parkinson-s-disease
#10
M Senek, M Hellström, J Albo, P Svenningsson, D Nyholm
BACKGROUND: Levodopa is the most effective symptomatic treatment throughout the course of Parkinson's disease, but as the disease progresses, there may be a need for individualized, fine-tuned treatments. AIM: To evaluate individualized levodopa/carbidopa dosing using microtablets dispensed with a dose dispenser, with respect to efficacy and usability as perceived by patients. METHODS: Patient records and dose dispenser reports from patients previously or currently treated with microtablets and a dose dispenser were reviewed, and a patient questionnaire concerning effect and usability was sent to patients...
March 15, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28294303/a-disease-disorder-illness-or-condition-how-to-label-epilepsy
#11
A J Noble, A Robinson, A G Marson
The International League Against Epilepsy (ILAE) is an important source of guidance for health professionals when it comes to epilepsy. Their latest recommendation that epilepsy should no longer be called a "disorder," but a "disease" has though caused controversy. The ILAE contends the change will improve epilepsy's image. Some clinicians and other organizations fear the change may not though be accepted by patients as in common parlance "disease" can be associated with "contagiousness"/"infection." To allow practicing clinicians to make informed judgements about what language they use, we completed the first study to assess the preferences of those with epilepsy and significant others and explore if any of their characteristics were associated with preference...
March 14, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28295152/causally-treatable-hereditary-neuropathies-in-fabry-s-disease-transthyretin-related-familial-amyloidosis-and-pompe-s-disease
#12
REVIEW
J Finsterer, J Wanschitz, S Quasthoff, S Iglseder, W Löscher, W Grisold
OBJECTIVES: Most acquired neuropathies are treatable, whereas genetic neuropathies respond to treatment in Fabry's disease (FD), transthyretin-related familial amyloidosis (TTR-FA), and Pompe's disease (PD). This review summarizes and discusses recent findings and future perspectives concerning etiology, pathophysiology, clinical presentation, diagnosis, treatment, and outcome of neuropathy in FD, TTR-FA, and PD. METHODS: Literature review. RESULTS: Neuropathy in FD concerns particularly small, unmyelinated, or myelinated sensory fibers (small fiber neuropathy [SFN]) and autonomic fibers, manifesting as acroparesthesias, Fabry's crises, or autonomous disturbances...
March 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28261782/neuroticism-depression-and-pain-perception-in-migraine-and-tension-type-headache
#13
S Ashina, L Bendtsen, D C Buse, A C Lyngberg, R B Lipton, R Jensen
OBJECTIVES: People with migraine and tension-type headache (TTH) have psychiatric comorbidities. We aimed to test differences in mental health constructs by type and frequency of primary headache and associated pain sensitivity. MATERIALS AND METHODS: Data on headache features, neuroticism (Eysenck Personality Questionnaire) and depression (Major Depression Inventory) were obtained from 547 individuals classified into chronic (≥15) or episodic (<15 headache days/month) and into pure migraine (n=43), pure tension type headache (TTH, n=97), migraine and TTH (n=83) and no headache diagnosis (controls, n=324) groups...
March 5, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28261781/cognitive-impairment-and-hippocampal-atrophy-in-chronic-kidney-disease
#14
C-Y Chang, C-C Lin, C-F Tsai, W-C Yang, S-J Wang, F-H Lin, J-L Fuh
BACKGROUND: Cognition impairment is well known in patients with chronic kidney disease (CKD). The relationship between brain structure and cognitive performance in CKD patients is still under investigation. The study aimed to quantitatively assess the relationship between brain structure and cognitive performance in patients with CKD. METHODS: We recruited 39 patients with CKD and 39 age- and sex-matched control participants from a tertiary medical center. All participants underwent 3-T MRI scan neuropsychological assessments, and renal function tests...
March 5, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28261780/cognition-in-non-demented-parkinson-s-disease-vs-essential-tremor-a-population-based-study
#15
Á Sánchez-Ferro, J Benito-León, E D Louis, I Contador, J Hernández-Gallego, V Puertas-Martín, F Bermejo-Pareja
OBJECTIVES: Patients with Parkinson's disease (PD) and essential tremor (ET) have a higher risk of cognitive impairment than age-matched controls. Only a few small studies (11-18 subjects per group) have directly compared the cognitive profile of these conditions. Our aim was to compare the cognitive profile of patients with these two conditions to each other and to healthy individuals in a population-based study of non-demented participants. MATERIALS AND METHODS: This investigation was part of the NEDICES study, a survey of the elderly in which 2438 dementia-free participants underwent a short neuropsychological battery...
March 5, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28251619/narcolepsy-patients-blood-based-mirna-expression-profiling-mirna-expression-differences%C3%A2-with-pandemrix-vaccination
#16
N Mosakhani, V Sarhadi, P Panula, M Partinen, S Knuutila
OBJECTIVES: Narcolepsy is a neurological sleep disorder characterized by excessive daytime sleepiness and nighttime sleep disturbance. Among children and adolescents vaccinated with Pandemrix vaccine in Finland and Sweden, the number of narcolepsy cases increased. Our aim was to identify miRNAs involved in narcolepsy and their association with Pandemrix vaccination. MATERIALS AND METHODS: We performed global miRNA proofing by miRNA microarrays followed by RT-PCR verification on 20 narcolepsy patients (Pandemrix-associated and Pandemrix-non-associated) and 17 controls (vaccinated and non-vaccinated)...
March 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28251609/elevated-body-temperature-in-ischemic-stroke-associated-with-neurological-improvement
#17
A N Khanevski, H Naess, L Thomassen, U Waje-Andreassen, A Nacu, C E Kvistad
OBJECTIVES: Some studies suggest that high body temperature within the first few hours of ischemic stroke onset is associated with improved outcome. We hypothesized an association between high body temperature on admission and detectable improvement within 6-9 hours of stroke onset. MATERIALS AND METHODS: Consecutive ischemic stroke patients with NIHSS scores obtained within 3 hours and in the interval 6-9 hours after stroke onset were included. Body temperature was measured on admission...
March 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28247411/reversed-aqueductal-cerebrospinal-fluid-net-flow-in-idiopathic-normal-pressure-hydrocephalus
#18
L K Yin, J J Zheng, L Zhao, X Z Hao, X X Zhang, J Q Tian, K Zheng, Y M Yang
OBJECTIVES: The changes of CSF flow dynamics in idiopathic normal pressure hydrocephalus (iNPH) are not fully elucidated. Most previous studies took the whole cardiac cycle as a unit. In this work, it is divided into systole and diastole phase and compared between iNPH patients and normal elderly and paid special attention to the change of netflow direction. MATERIALS AND METHODS: Twenty iNPH patients according to international guideline and twenty healthy volunteers were included in this study and examined by MRI...
March 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28244170/population-based-incidence-and-clinical-characteristics-of-idiopathic-intracranial-hypertension
#19
A Sundholm, S Burkill, O Sveinsson, F Piehl, S Bahmanyar, A I M Nilsson Remahl
OBJECTIVE: To validate the diagnosis of idiopathic intracranial hypertension (IIH) from the Swedish National Patient Register (NPR) and investigate the incidence of IIH, as well as co-morbidities and medication use in a large Swedish population-based sample. METHODS: We searched the NPR to find all patients ≥18 years old with the ICD-10 diagnosis code (G93.2) for IIH in Stockholm County from Jan 1, 2006, to Dec 31, 2013. All medical records were reviewed to validate the diagnosis and to collect additional information...
February 28, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28239850/depressive-symptomology-in-multiple-sclerosis-disability-cardiorespiratory-fitness-and-heart-rate-variability
#20
I Ensari, L A Pilutti, R W Motl
OBJECTIVES: This study aimed to investigate whether neurological disability status, heart rate variability (HRV), cardiorespiratory fitness (CRF) explained the variance in depressive symptoms in multiple sclerosis (MS). METHODS: Associations between CRF (via maximal oxygen uptake; VO2peak ), HRV indices of normalized ultra-low (nULF) and very low frequency domains (nVLF), neurological disability status and depressive symptoms (using the Depression subscale of the Hospital Anxiety Depression Scale; HADS-D) were assessed in 53 participants with MS and 17 matched controls...
February 26, 2017: Acta Neurologica Scandinavica
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