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Acta Neurologica Scandinavica

V Villanueva, F J López-González, J A Mauri, J Rodriguez-Uranga, M Olivé-Gadea, J Montoya, J Ruiz-Giménez, J Zurita
OBJECTIVES: Evaluate long-term effectiveness and tolerability of brivaracetam in clinical practice in patients with focal epilepsy. MATERIALS AND METHODS: This was a multicentre retrospective study. Patients aged ≥16 years were started on brivaracetam from November 2016 to June 2017 and followed over 1 year. Data were obtained from medical records at 3, 6 and 12 months after treatment initiation for evaluation of safety- and seizure-related outcomes. RESULTS: 575 patients were included in analyses; most had been treated with ≥4 lifetime antiepileptic drugs...
December 1, 2018: Acta Neurologica Scandinavica
Dong Wook Kim, Jeeyoung Oh
BACKGROUND: Previous studies on elderly epilepsy included only patients with new-onset disease, but there are many patients who developed epilepsy earlier and aged. AIM: We compared the characteristics of new-onset and persistence epilepsy in the elderly. METHODS: We performed a 10-year retrospective analysis of elderly patients with epilepsy divided into two groups according to the onset of seizure: new-onset epilepsy (onset age≥65) and persistent epilepsy (onset age<65)...
November 28, 2018: Acta Neurologica Scandinavica
Anna-Leena Pirttisalo, Merja Soilu-Hänninen, Jussi O T Sipilä
OBJECTIVES: Studies on the east-west gradient of multiple sclerosis (MS) are scarce. In Finland, epidemiological differences have been only partially elucidated, but the MS risk is high, and it has been claimed that the occurrence follows a longitudinal gradient. In this register-based study, we updated the MS epidemiology in southwest Finland (SwF) and compared it to the easternmost hospital district, North Karelia (NK), for which no previous data exist. MATERIAL AND METHODS: Patients with ICD-10 code G35 were identified from hospital district administrative data...
November 27, 2018: Acta Neurologica Scandinavica
Signe Bruun Munksgaard, Csaba Ertsey, Erik Frandsen, Lars Bendtsen, Kornelia Tekes, Rigmor Højland Jensen
BACKGROUND: Previous studies found low serum levels of nociceptin in migraine patients but high serum levels of calcitonin gene-related peptide (CGRP). CGRP can elicit migraine-like headache. Medication-Overuse Headache (MOH) often has migraine features and can mimic chronic migraine. We therefore hypothesized that as in migraine, serum levels of nociceptin would be lower and CGRP serum levels higher in MOH patients compared with those in healthy volunteers. We hypothesized the serum levels would normalize after detoxification...
November 20, 2018: Acta Neurologica Scandinavica
Feng-Tao Liu, Li-Qin Lang, Yu-Jie Yang, Jue Zhao, Rui Feng, Jie Hu, Jian Wang, Jian-Jun Wu
INTRODUCTION: Subthalamic deep brain stimulation (STN-DBS) has been reported to improve the quality of life (QoL) related to Parkinson's disease (PD). However, not all subjects are satisfied with the postsurgical QoL outcome. We aimed to detect the related factors and possible predictors to QoL improvement for those PD patients one year after STN DBS. MATERIALS & METHODS: 45 PD patients with bilateral STN-DBS surgery were included and followed up for 1 year...
November 19, 2018: Acta Neurologica Scandinavica
Tomohiko Shiina, Keisuke Suzuki, Madoka Okamura, Takeo Matsubara, Koichi Hirata
BACKGROUND: The clinical-radiological correlation between restless legs syndrome (RLS) or its variants and acute ischemic stroke remains unclear. METHODS: This study prospectively included 104 consecutive patients with acute ischemic stroke, confirmed by diffusion-weighted imaging. The frequency and clinical characteristics of RLS or RLS variants were evaluated according to the International RLS Study Group criteria, as was the topography of the associated lesions...
November 18, 2018: Acta Neurologica Scandinavica
Assunta Dal-Bianco, Fritz Wenhoda, P S Rommer, Michael Weber, Patrick Altmann, Jörg Kraus, Fritz Leutmezer, Sabine Salhofer-Polanyi
OBJECTIVES: The incidence and clinical impact of serum autoantibodies in patients with multiple sclerosis (MS) is controversially discussed. The aim of the study is to reassess the value of elevated serum autoantibodies in our MS study cohort. MATERIAL & METHODS: 176 MS patients were retrospectively analyzed for coexistence and clinical impact of increased serum autoantibody levels. RESULTS: 18.8% of the MS cohort showed elevated serum autoantibody levels, but only 10...
November 17, 2018: Acta Neurologica Scandinavica
Christopher M DeGiorgio, Ashley Curtis, Dieter Hertling, Brian D Moseley
Sudden unexpected death in epilepsy (SUDEP) is one of the most important direct epilepsy-related causes of death, with an incidence in adults of 1.2 per 1000 person years. Generalized tonic-clonic seizures have consistently emerged as the leading risk factor for SUDEP, particularly when such seizures are uncontrolled. High seizure burden, lack of antiepileptic drug (AED) treatment, polytherapy, intellectual disability, and prone position at the time of death are other key risk factors. Unfortunately, despite advances in treatment, overall mortality rates in epilepsy are rising...
November 15, 2018: Acta Neurologica Scandinavica
Katie A Peterson, Tom B Mole, Nicole C H Keong, Elise E DeVito, George Savulich, John D Pickard, Barbara J Sahakian
OBJECTIVES: The pathological bases for the cognitive and neuropsychiatric symptoms in normal pressure hydrocephalus (NPH) have not been elucidated. However, the symptoms may indicate dysfunction of subcortical regions. Previously, volume reductions of subcortical deep grey matter (SDGM) structures have been observed in NPH patients. The present study used automated segmentation methods to investigate whether SDGM structure volumes are associated with cognitive and neuropsychiatric measures...
November 14, 2018: Acta Neurologica Scandinavica
ZhiYong Zeng, YunPeng Li, ShunYu Lu, WanSu Huang, Wei Di
OBJECTIVES: Migraine ranks among the most frequent neurological disorders globally. Co-enzyme Q10 (CoQ10) is a nutritional agent that might play a preventative role in migraine. This meta-analysis aimed to investigate the effects of CoQ10 as a supplemental agent in migraine. SUBJECTS AND METHODS: Web of Science, PubMed and Cochrane Library were searched for potential articles that assessed the effects of CoQ10 on migraine. Data were extracted by two independent reviewers and analyzed with Revman 5...
November 14, 2018: Acta Neurologica Scandinavica
Li Jiang, DongLi Yuan, Maolin Li, Chaoyang Liu, Qing Liu, Yixin Zhang, Ge Tan
OBJECTIVE: This study is aimed to access the efficacy and safety of combination therapy of flunarizine plus transcutaneous supraorbital neurostimulation (tSNS) compared with either flunarizine or tSNS alone for migraine prophylaxis. METHODS: Patients with episodic migraine were enrolled and randomized into three groups. Flunarizine 5 mg per day, or tSNS for 20 minutes daily or combination of both were prescribed consecutively for 3 months. The primary outcome measures were changes in migraine days and 50% responder rate of monthly migraine days...
November 14, 2018: Acta Neurologica Scandinavica
Weixi Xiong, Lin Tang, Lu Lu, Le Zhang, Yingfeng Xiao, Dong Zhou
OBJECTIVES: GATOR1 (Gap Activity TOward Rags 1) is composed of three different subunits, DEPDC5 (DEP domain-containing protein 5), NPRL2 (nitrogen permease regulator-like 2), and NPRL3 (nitrogen permease regulator-like 3), and variants in these three genes have mostly been reported in familial focal epilepsy. However, very few studies have been carried out on sporadic drug-resistant focal epilepsy patients. In this study, we aimed to identify the frequency of variants in DEPDC5, NPRL2 and NPRL3 in patients with sporadic drug-resistant focal epilepsy...
November 14, 2018: Acta Neurologica Scandinavica
P Melbye, A Olsson, T H Hansen, H B Søndergaard, A B Oturai
BACKGROUND: Multiple Sclerosis (MS) is a chronic immune mediated neurological disease of the central nervous system with a complex and still not fully understood aetiology. In recent years, the gut microbiota and fermentative metabolites like short-chain fatty acids (SCFAs) have received increased attention in relation to the development and disease course of MS. This systematic review highlights and summarizes the existing literature within this field. METHODS: A systematic search in PubMed was conducted on October 12th , 2017, to find published original studies on SCFAs and their impact on MS and the animal model of MS experimental autoimmune encephalomyelitis (EAE)...
November 14, 2018: Acta Neurologica Scandinavica
Helle Herrman, Arild Egge, Ane E Konglund, Jon Ramm Pettersen, Espen Dietrichs, Erik Taubøll
OBJECTIVES: The safety and effect on seizure frequency of anterior thalamic nucleus deep brain stimulation (ANT-DBS) were studied in this prospective, randomized, double-blinded study. Patients were followed for 12 months. The first 6 months were blinded with regard to active stimulation or not. After 6 months, all patients received active stimulation. MATERIAL AND METHODS: Bilateral ANT electrodes were implanted into 18 patients suffering from focal, pharmacoresistant epilepsy...
November 14, 2018: Acta Neurologica Scandinavica
Anders Wåhlin, Helena Fordell, Urban Ekman, Niklas Lenfeldt, Jan Malm
OBJECTIVES: Rehabilitation of patients with chronic visuospatial neglect is underexplored, and little is known about neural mechanisms that can be exploited to promote recovery. In this study, we present data on resting state functional connectivity within the dorsal attention network (DAN) in chronic neglect patients as they underwent training in a virtual reality (VR) environment that improved left-side awareness. METHODS: The study included 13 patients with visuospatial neglect persisting more than six months after a right-sided stroke...
November 14, 2018: Acta Neurologica Scandinavica
Maria Steenhof, Nete Munk Nielsen, Egon Stenager, Kirsten Kyvik, Sören Möller, Jens Michael Hertz
OBJECTIVES: The overall distribution of disease courses in multiple sclerosis (MS) is well established, but little is known about the distribution among familial MS cases. We examine the frequency of the different MS courses among familial and sporadic MS cases and determine whether MS cases within the same family had the same age at diagnosis and have experienced the same disease course. MATERIALS AND METHODS: This is a nationwide register study, based on data from the Danish MS Registry, the Danish Civil Registration System and the Danish National Patient Registry...
November 9, 2018: Acta Neurologica Scandinavica
Johannes Dorst, Georg Behrendt, Albert C Ludolph
OBJECTIVES: During the course of amyotrophic lateral sclerosis (ALS), progressive weakness of respiratory muscles leads to chronic hypercapnia which causes various symptoms like sleep disturbances, daytime fatigue, and depression. Non-invasive ventilation (NIV) improves survival and quality of life, but little is known about its effect on these specific symptoms, in particular during the later course of disease. Our aim was to evaluate the short- and long-term effects of NIV on hypercapnia-associated symptoms in ALS...
November 5, 2018: Acta Neurologica Scandinavica
Marte Syvertsen, Ida Fløgstad, Ulla Enger, Cecilie Johannessen Landmark, Jeanette Koht
OBJECTIVES: Withdrawal of antiepileptic drugs (AEDs) has been discouraged in juvenile myoclonic epilepsy (JME). However, impulsivity as a consequence of executive dysfunction in JME may influence treatment adherence. The aim of the present study was to assess how common withdrawal of AEDs is in a large and representative JME group. MATERIALS AND METHODS: Patients with genetic generalized epilepsy (GGE) were identified through a retrospective search of medical records at Drammen Hospital, Norway, and invited to a clinical interview...
October 31, 2018: Acta Neurologica Scandinavica
Brian M Sandroff, Jessica F Baird, Stephanie L Silveira, Robert W Motl
BACKGROUND: Exercise-training is a beneficial approach for improving function in persons with multiple sclerosis(MS). However, it is unlikely that every participant who engages in an exercise-training intervention will demonstrate similar benefits. Identifying factors that may influence the accrual of specific exercise-training benefits can aid in the development of optimized rehabilitation interventions for improving specific outcomes in MS. OBJECTIVE: This study described possible response heterogeneity in physical fitness, mobility, and cognitive outcomes with exercise training and identified baseline performance, compliance, and demographic/clinical outcomes as possible predictors of exercise-related changes in those outcomes...
October 29, 2018: Acta Neurologica Scandinavica
K Dahlbom, M Geijer, A Oldfors, C Lindberg
OBJECTIVES: Inclusion body myositis is characterized by inflammatory and degenerative changes, but the temporal relation of these events is unknown. MATERIALS AND METHODS: In nineteen patients with inclusion body myositis muscle strength was correlated with inflammatory and degenerative findings on MRI and in muscle biopsies in three different muscles (tibialis anterior, vastus lateralis, biceps brachii). Muscle strength, measured with a hand-held dynamometer, was described as percentage of muscle strength in age and sex matched normal individuals...
October 22, 2018: Acta Neurologica Scandinavica
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