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Acta Clinica Belgica

Lieven Dupont, Charles Pilette, Florence Schleich, Guy Joos
OBJECTIVES: Non-adherence to asthma medication can lead to lower disease control and asthma exacerbations that may be fatal. This survey assessed the attitude and expectations of Belgian asthma patients towards their treatment. METHODS: This cross-sectional survey was conducted between June 2015 and February 2016 in 70 Belgian pharmacies. Participants completing the survey had to be ≥15 years, diagnosed with asthma, and on inhaled corticosteroid-based treatment...
January 14, 2019: Acta Clinica Belgica
Julie Kips, Jo Lambert, Katia Ongenae, An De Sutter, Evelien Verhaeghe
BACKGROUND: Teledermatology, the application of telemedicine in the field of dermatology, can be a valuable tool to improve the efficiency of care in general practice. OBJECTIVES: In this pilot study, we implemented a teledermatology programme in Belgian context to assess the effect on referral rate and to evaluate the acceptability of teledermatology by clinicians and patients. MATERIAL AND METHODS: A store-and-forward teledermatology service between 12 general practitioners (GPs) and 3 academic dermatologists was evaluated for a period of 3-6 months...
January 8, 2019: Acta Clinica Belgica
Celine Bultynck, N Munim, D J Harrington, L Judd, F Ataklte, Z Shah, F Dockery
INTRODUCTION: Vitamin K plays an important role in blood coagulation. Diet is the main source of vitamin K and body stores are depleted in days, hence deficiency is common in malnourished older people. A high proportion of people who sustain a hip fracture are already malnourished, compounded by fasting for surgery which might further increase deficiency. We wanted to explore the prevalence of vitamin K deficiency in hip fracture patients and the impact of a short period of fasting. METHODS: In consecutive patients hospitalised with a hip fracture, we measured vitamin K and PIVKA-II (undercarboxylated factor II - a marker of subclinical vitamin K status) on admission and on first post-operative day...
January 8, 2019: Acta Clinica Belgica
F Damas, K Ghysen, F Gester, V Heinen, B Duysinx, R Louis, J Guiot
Immunoglobulin G4-related disease is a rare autoimmune systemic disease with the capability of involving every organ. The disease is microscopically defined by a diffuse tissular inflammation with an infiltration of IgG4 positive plasma cells in the affected organs. IgG4 disease has an increasing incidence in the last few years with a growing interest in its pathophysiology still misunderstood to date. Despite the growing recognition of this pathology, the literature still does not allow to propose a simple diagnostic algorithm...
January 8, 2019: Acta Clinica Belgica
Gaetan Catala, Jeroen Mebis, Guy Jerusalem, Didier Verhoeven, Ahmad Awada, Alain Bols, Luc Somers, Anke Van Den Broeck, Francois P Duhoux, Jean-Pascal Machiels
BACKGROUND: Chemotherapy plays an important role in the treatment of early breast cancer (EBC). Granulocyte-colony stimulating factors (G-CSF) can reduce the risk of febrile neutropenia as primary prophylaxis (PP) or secondary prophylaxis (SP). The BRONS study investigated the incidence of serious neutropenic events (SNE) and G-CSF use in a Belgian population of EBC patients treated with myelosuppressive polychemotherapy. METHODS: Conducted in 2011, this study was a prospective, multicentre, observational trial involving 260 patients...
January 4, 2019: Acta Clinica Belgica
Lara Moons, An Mariman, Peter Vermeir, Luc Colemont, Els Clays, Hans Van Vlierberghe, Dirk Vogelaers
BACKGROUND: Worldwide colorectal cancer is a frequently occurring cancer with a high disease burden. It is the second most frequent cancer in women and the third in men. The incidence of colorectal cancer is increasing because of ageing and unhealthy lifestyles. AIM: We aimed to perform a narrative literature review on methods and strategies for screening for colorectal cancer prior to colonoscopy. DESIGN: Narrative literature review. METHODS: The databases PubMed, Web of Science, Embase and The Cochrane Library were searched using keywords: 'colorectal cancer', '(mass) screening', 'occult blood', 'prevention', 'socioeconomic status', 'early diagnosis', 'Europe' and 'ethnicity'/'ethnic groups'...
January 4, 2019: Acta Clinica Belgica
Philippe Oriot, Michel P Hermans
INTRODUCTION: Glycated hemoglobin (A1c ) is the measurement of choice to estimate the glycemic exposure over the last 3 months prior to sampling. The Free Style Libre® is a continuous glucose monitoring device which provides an estimated A1c (eA1c) from average interstitial glucose using Nathan's ADAG equation. The objective of this study was to compare eA1c and A1c in type 1 diabetes patients (T1D) over a period of 3 months. MATERIALS AND METHODS: Data were collected from patient charts between July 2016 and October 2017...
December 31, 2018: Acta Clinica Belgica
Marzia Verhaeghe, Saïd Hachimi-Idrissi
OBJECTIVE: Blood lactate concentration (L) and lactate kinetic (LK) over time might be a helpful marker of the shock severity. The purpose of this study is to analyze whether the L and LK could correlate with the outcome and the therapy of patients with different types of shock. METHODS: Design: A 3.5-year retrospective observational study. PATIENTS: Eighteen years of age or older, diagnosed with shock were included. Arterial L measurements were performed upon admission and approximatively 3 and 6 h later...
December 28, 2018: Acta Clinica Belgica
Ataman Gönel
OBJECTIVES: The purpose of this study is to investigate the elimination ratios of requested unnecessary tests and the cost-effectiveness to be achieved by means of 5 different algorithms with clinical validity defined in an artificial intelligence program. METHODS: The clinician orders received from the hospital information management system were adapted to eliminate AST, direct bilirubin, chlorine, fPSA and fT3 tests using five different algorithms defined in the ALIN IQ software...
December 25, 2018: Acta Clinica Belgica
Davor Kust, Neven Matesa
OBJECTIVES: Hashimoto's thyroiditis (HT) is a common autoimmune disease. Available data show that HT develops as a result of interaction between genetic susceptibility and environmental factors, but the exact pathogenesis of the disease is not yet fully understood. The aim of this investigation is to evaluate the potential relationship between family history of HT and the development of HT. METHODS: Data regarding family history of all patients who were referred for a diagnostic evaluation of thyroid function for any reason between May 2014 and May 2018 was analyzed...
December 20, 2018: Acta Clinica Belgica
Klaas Dewaele, Johan Frans, Annick Smismans, Erwin Ho, Tim Tollens, Katrien Lagrou
OBJECTIVE AND IMPORTANCE: Candida auris is a relatively new yeast species and an emerging opportunistic pathogen. It was first reported in 2009 in East Asia, as a difficult-to-identify Candida species of uncertain clinical relevance. In recent years, it has appeared globally as a cause of invasive infections, not infrequently eliciting nosocomial outbreaks. Species identification in clinical laboratories has been challenging, as traditional phenotypic and biochemical methods have been generally unreliable...
December 4, 2018: Acta Clinica Belgica
Yasser Farid, Charlotte Martin, Marc Delforge, Stephane De Wit
OBJECTIVES: Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are both worldwide health concerns with similar routes of transmission and no curative treatment to date. Coinfection is associated with increased morbidity and mortality. We aim to provide epidemiological data about HIV-HBV coinfected patients and asses if management of patients following European recommendation (EACS) was achieved in a large AIDS Reference Center in Belgium. METHODS: Retrospective review of the HIV database of Saint-Pierre University Hospital in Brussels (Belgium) focusing on HIV-HBV coinfected patients in active follow-up...
December 4, 2018: Acta Clinica Belgica
Amir Shamshirian, Ali Reza Mohseni, Ali Akbar Pourfathollah, Shirin Mehdipour, Samira Hosseini, Atiyeh Ghorbanpour, Soheil Azizi
BACKGROUND/OBJECTIVES: Blood is a vital resource that its utilization is ever increasing throughout the world and blood wastage is a global challenge that needs to be controlled. Most blood resources are used during complications of pregnancy, trauma, severe childhood anemia, gynecology, cancers, surgery, hematology disorders, and chronic diseases. Units that are expired, broken bags, returning the blood unit after 30 min, blood clotted units, etc., which are due to lack of awareness may result in the wastage of blood products...
December 4, 2018: Acta Clinica Belgica
Sara David, Kathleen De Waele, Bram De Wilde, Franny Faes, Olivier Vanakker, Sophie Walraedt, Agnieszka Prytuła
We describe a boy who presented with neonatal hypotonia, followed by delayed motor development and growth impairment. Further evaluation revealed rickets caused by proximal renal tubular dysfunction. At age 3, the boy exhibited dysmorphic features and bilateral cataract. Genetic analysis of the OCRL gene showed a novel variant in exon 13: c.1250T>A, p.Val417Asp; in silico and segregation analysis confirmed the variant to be pathogenic, compatible with the diagnosis of the oculocerebrorenal syndrome of Lowe...
December 3, 2018: Acta Clinica Belgica
Lorenz Haaker, Elisabeth De Meue, Hans Wildiers, Annelies Verbiest, Herlinde Dumez, Evelyne Lerut, Steven Pans, Maarten Albersen, Benoit Beuselinck
BACKGROUND: Metastatic clear-cell renal cell carcinoma (m-ccRCC) patients with bone metastases (BM) treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) have a poorer outcome compared to patients without BM. We aimed to investigate whether an increased incidence of VEGFR-TKI treatment interruptions and/or dose reductions in patients with BM could explain this difference in outcome. PATIENTS AND METHODS: Retrospective study on m-ccRCC patients treated in first-line with VEGFR-TKI...
November 29, 2018: Acta Clinica Belgica
Liesbeth De Waele, Pieter-Jan Van Gaal, Daniel Abramowicz
OBJECTIVES: Water and electrolytes disturbances often occur in renal transplant recipients. The objective is to describe the pathophysiology and the treatment of the most prevalent abnormalities. METHODS: We screened PubMed for the following words in various combination: kidney transplantation and (disturbances or abnormalities) of (electrolytes or sodium or potassium or phosphate or calcium or acid-base). RESULTS: We found abnormalities in all major electrolytes, as a consequence of tubular dysfunction caused by both rejection episodes and toxic effects of calcineurin inhibitors (CNIs; cyclosporine or tacrolimus)...
November 27, 2018: Acta Clinica Belgica
Bert Dhondt, Sarah Buelens, Jeroen Van Besien, Matthias Beysens, Elise De Bleser, Piet Ost, Nicolaas Lumen
OBJECTIVES:  Disease progression in metastatic castration-resistant prostate cancer (mCRPC) is dependent on androgen signaling. This case describes the complex adaptive androgen signaling mechanisms in mCRPC and illustrates that caution should be exercised when treating these patients with drugs influencing the androgen axis. METHODS:  Single case report and review of the literature. RESULTS:  We report the case of an 86-year-old man with mCRPC, treated with the secondary antihormonal agent abiraterone acetate...
November 26, 2018: Acta Clinica Belgica
Jill Vanmassenhove, Norbert Lameire
No abstract text is available yet for this article.
November 24, 2018: Acta Clinica Belgica
Meltem Koca, Abdulsamet Erden, Berkan Armagan, Alper Sari, Fatih Yildiz, Sevim Ozdamar, Umut Kalyoncu, Omer Karadag
Muscle weakness is a nonspecific finding of myopathy of any etiology that include iatrogenic, toxic, endocrinological, infectious, immunologic, and metabolic disorders. Among the metabolic myopathies glutaric aciduria type II (GAII) is an autosomal recessively inherited rare disorder of fatty acid and amino acid metabolisms. The late onset form is heterogeneous in terms of symptomatology and severity and for the cases that chronic manifestations of lipid storage myopathy are the only clues for the disease, differential diagnosis can be challenging...
November 19, 2018: Acta Clinica Belgica
Planté-Bordeneuve Thomas, Haouas Hanae, Vanderheyde Kim, Froidure Antoine
OBJECTIVES: Monogenic pulmonary fibrosis related to telomerase mutations is characterized by a large spectrum of clinical presentations. The disease may affect several organs including bone marrow, liver and skin. This case illustrates some of the most salient features of telomere-related Interstitial Lung Disease(ILD). METHODS:  Single case study and review of the litterature. RESULTS: We report the case of a 44-year-old man admitted to our unit for subacute pulmonary fibrosis...
November 19, 2018: Acta Clinica Belgica
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