Xingliang Zhu, Yuyoung Joo, Simone Bossi, Ross A McDevitt, Aoji Xie, Yue Wang, Yutong Xue, Shuaikun Su, Seung Kyu Lee, Nirnath Sah, Shiliang Zhang, Rong Ye, Alejandro Pinto, Yongqing Zhang, Kimi Araki, Masatake Araki, Marisela Morales, Mark P Mattson, Henriette van Praag, Weidong Wang
The Topoisomerase 3B (Top3b) - Tudor domain containing 3 (Tdrd3) protein complex is the only dual-activity topoisomerase complex that can alter both DNA and RNA topology in animals. TOP3B mutations in humans are associated with schizophrenia, autism and cognitive disorders; and Top3b-null mice exhibit several phenotypes observed in animal models of psychiatric and cognitive disorders, including impaired cognitive and emotional behaviors, aberrant neurogenesis and synaptic plasticity, and transcriptional defects...
January 10, 2024: Progress in Neurobiology