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Progress in Neurobiology

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https://www.readbyqxmd.com/read/28322921/linking-deregulation-of-non-coding-rna-to-the-core-pathophysiology-of-alzheimer-s-disease-an-integrative-review
#1
REVIEW
Mark J Millan
The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of particular interest since their deregulation has been implicated in neurodegenerative disorders like Alzheimer's disease (AD). However, it remains challenging to link the complex body of observations on miRNAs and AD into a coherent framework. Using extensive graphical support, this article discusses how a diverse panoply of miRNAs convergently and divergently impact (and are impacted by) core pathophysiological processes underlying AD: neuroinflammation and oxidative stress; aberrant generation of β-amyloid-42 (Aβ42); anomalies in the production, cleavage and post-translational marking of Tau; impaired clearance of Aβ42 and Tau; perturbation of axonal organisation; disruption of synaptic plasticity; endoplasmic reticulum stress and the unfolded protein response; mitochondrial dysfunction; aberrant induction of cell cycle re-entry; and apoptotic loss of neurons...
March 17, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28322920/stem-cell-transplantation-therapy-for-multifaceted-therapeutic-benefits-after-stroke
#2
REVIEW
Ling Wei, Zheng Z Wei, Michael Qize Jiang, Osama Mohamad, Shan Ping Yu
One of the exciting advances in modern medicine and life science is cell-based neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The progress in stem cell biology and creation of adult induced pluripotent stem (iPS) cells has significantly improved basic and pre-clinical research in disease mechanisms and generated enthusiasm for potential applications in the treatment of central nervous system (CNS) diseases including stroke. Endogenous neural stem cells and cultured stem cells are capable of self-renewal and give rise to virtually all types of cells essential for the makeup of neuronal structures...
March 16, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28274676/islet-amyloid-polypeptide-another-key-molecule-in-alzheimer-s-pathogenesis
#3
REVIEW
Yun Zhang, Weihong Song
Recent epidemiological evidence reveals that patients suffering from type 2 diabetes mellitus (T2DM) often experience a significant decline in cognitive function, and approximately 70% of those cases eventually develop Alzheimer's disease (AD). Although several pathological processes are shared by AD and T2DM, the exact molecular mechanisms connecting these two diseases are poorly understood. Aggregation of human islet amyloid polypeptide (hIAPP), the pathological hallmark of T2DM, has also been detected in brain tissue and is associated with cognitive decline and AD development...
March 6, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28268181/ethical-challenges-in-developing-drugs-for-psychiatric-disorders
#4
REVIEW
Felix Carrier, David Banayan, Randy Boley, Niranjan Karnik
As the classification of mental disorders advances towards a disease model as promoted by the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC), there is hope that a more thorough neurobiological understanding of mental illness may allow clinicians and researchers to determine treatment efficacy with less diagnostic variability. This paradigm shift has presented a variety of ethical issues to be considered in the development of psychiatric drugs. These challenges are not limited to informed consent practices, industry funding, and placebo use...
March 6, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28259728/neurobiology-and-neuropharmacology-of-monoaminergic-systems
#5
EDITORIAL
Philippe De Deurwaerdère, Rona R Ramsay, Giuseppe Di Giovanni
No abstract text is available yet for this article.
March 2, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28189739/potential-of-gpcrs-to-modulate-mapk-and-mtor-pathways-in-alzheimer-s-disease
#6
REVIEW
Rafael Franco, Eva Martínez-Pinilla, Gemma Navarro, Marta Zamarbide
Despite efforts to understand the mechanism of neuronal cell death, finding effective therapies for neurodegenerative diseases is still a challenge. Cognitive deficits are often associated with neurodegenerative diseases. Remarkably, in the absence of consensus biomarkers, diagnosis of diseases such as Alzheimer's still relies on cognitive tests. Unfortunately, all efforts to translate findings in animal models to the patients have been unsuccessful. Alzheimer's disease may be addressed from two different points of view, neuroprotection or cognitive enhancement...
February 9, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28189740/anesthesia-brain-changes-and-behavior-insights-from-neural-systems-biology
#7
REVIEW
Elisabeth Colon, Edward A Bittner, Barry Kussman, Mary Ellen McCann, Sulpicio Soriano, David Borsook
Long-term consequences of anesthetic exposure in humans are not well understood. It is possible that alterations in brain function occur beyond the initial anesthetic administration. Research in children and adults has reported cognitive and/or behavioral changes after surgery and general anesthesia that may be short lived in some patients, while in others, such changes may persist. The changes observed in humans are corroborated by a large body of evidence from animal studies that support a role for alterations in neuronal survival (neuroapoptosis) or structure (altered dendritic and glial morphology) and later behavioral deficits at older age after exposure to various anesthetic agents during fetal or early life...
February 8, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28159574/subthalamic-nucleus-deep-brain-stimulation-on-motor-symptoms-of-parkinson-s-disease-focus-on-neurochemistry
#8
REVIEW
A Stefani, V Trendafilov, C Liguori, E Fedele, S Galati
Deep brain stimulation (DBS) has become a standard therapy for Parkinson's disease (PD) and it is also currently under investigation for other neurological and psychiatric disorders. Although many scientific, clinical and ethical issues are still unresolved, DBS delivered into the subthalamic nucleus (STN) has improved the quality of life of several thousands of patients. The mechanisms underlying STN-DBS have been debated extensively in several reviews; less investigated are the biochemical consequences, which are still under scrutiny...
January 31, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28143732/microglia-in-cns-development-shaping-the-brain-for-the-future
#9
REVIEW
Coralie-Anne Mosser, Sofia Baptista, Isabelle Arnoux, Etienne Audinat
Microglial cells are the resident macrophages of the central nervous system (CNS) and are mainly known for their roles in neuropathologies. However, major recent developments have revealed that these immune cells actively interact with neurons in physiological conditions and can modulate the fate and functions of synapses. Originating from myeloid precursors born in the yolk sac, microglial cells invade the CNS during early embryonic development. As a consequence they can potentially influence neuronal proliferation, migration and differentiation as well as the formation and maturation of neuronal networks, thereby contributing to the entire shaping of the CNS...
January 28, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28110083/preconditioning-in-neuroprotection-from-hypoxia-to-ischemia
#10
REVIEW
Sijie Li, Adam Hafeez, Fatima Noorulla, Xiaokun Geng, Guo Shao, Changhong Ren, Guowei Lu, Heng Zhao, Yuchuan Ding, Xunming Ji
Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon has been termed hypoxic or ischemic preconditioning (HPC or IPC) and is well established in the heart and the brain. This review aims to discuss HPC and IPC with respect to their historical development and advancements in our understanding of the neurochemical basis for their neuroprotective role. Through decades of collaborative research and studies of HPC and IPC in other organ systems, our understanding of HPC and IPC-induced neuroprotection has expanded to include: early- (phosphorylation targets, transporter regulation, interfering RNA) and late- (regulation of genes like EPO, VEGF, and iNOS) phase changes, regulators of programmed cell death, members of metabolic pathways, receptor modulators, and many other novel targets...
January 18, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/27890810/interaction-of-language-auditory-and-memory-brain-networks-in-auditory-verbal-hallucinations
#11
REVIEW
Branislava Ćurčić-Blake, Judith M Ford, Daniela Hubl, Natasza D Orlov, Iris E Sommer, Flavie Waters, Paul Allen, Renaud Jardri, Peter W Woodruff, Olivier David, Christoph Mulert, Todd S Woodward, André Aleman
Auditory verbal hallucinations (AVH) occur in psychotic disorders, but also as a symptom of other conditions and even in healthy people. Several current theories on the origin of AVH converge, with neuroimaging studies suggesting that the language, auditory and memory/limbic networks are of particular relevance. However, reconciliation of these theories with experimental evidence is missing. We review 50 studies investigating functional (EEG and fMRI) and anatomic (diffusion tensor imaging) connectivity in these networks, and explore the evidence supporting abnormal connectivity in these networks associated with AVH...
January 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/27979736/the-expanding-horizon-of-micrornas-in-cellular-reprogramming
#12
REVIEW
Yogita K Adlakha, Pankaj Seth
Research over the last few years in cellular reprogramming has enlightened the magical potential of microRNAs (miRNAs) in changing the cell fate from somatic to pluripotent. Recent investigations on exploring the role(s) of miRNAs in somatic cell reprogramming revealed that they target a wide range of molecules and refine their protein output. This leads to fine tuning of distinct cellular processes including cell cycle, signalling pathways, transcriptional activation/silencing and epigenetic modelling. The concerted actions of miRNA on different pathways simultaneously strengthen the transition from a differentiated to de-differentiated state...
December 12, 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27916623/multiple-beneficial-effects-of-melanocortin-mc4-receptor-agonists-in-experimental-neurodegenerative-disorders-therapeutic-perspectives
#13
REVIEW
Daniela Giuliani, Alessandra Ottani, Laura Neri, Davide Zaffe, Paolo Grieco, Jerzy Jochem, Gian Maria Cavallini, Anna Catania, Salvatore Guarini
Melanocortin peptides induce neuroprotection in acute and chronic experimental neurodegenerative conditions. Melanocortins likewise counteract systemic responses to brain injuries. Furthermore, they promote neurogenesis by activating critical signaling pathways. Melanocortin-induced long-lasting improvement in synaptic activity and neurological performance, including learning and memory, sensory-motor orientation and coordinated limb use, has been consistently observed in experimental models of acute and chronic neurodegeneration...
December 1, 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27769868/oxidative-stress-a-major-pathogenesis-and-potential-therapeutic-target-of-antioxidative-agents-in-parkinson-s-disease-and-alzheimer-s-disease
#14
REVIEW
Tianfang Jiang, Qian Sun, Shengdi Chen
Oxidative stress reflects an imbalance between the overproduction and incorporation of free radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free radicals produced by oxidative stress are one of the common features in several experimental models of diseases. Free radicals affect both the structure and function of neural cells, and contribute to a wide range of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Although the precise mechanisms that result in the degeneration of neurons and the relevant pathological changes remain unclear, the crucial role of oxidative stress in the pathogenesis of neurodegenerative diseases is associated with several proteins (such as α-synuclein, DJ-1, Amyloid β and tau protein) and some signaling pathways (such as extracellular regulated protein kinases, phosphoinositide 3-kinase/Protein Kinase B pathway and extracellular signal-regulated kinases 1/2) that are tightly associated with the neural damage...
December 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27609181/erratum-to-calpains-and-neuronal-damage-in-the-ischemic-brain-the-swiss-knife-in-synaptic-injury-progress-in-neurobiology-143-2016-1-35
#15
Michele Curcio, Ivan L Salazar, Miranda Mele, Lorella M T Canzoniero, Carlos B Duarte
No abstract text is available yet for this article.
December 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27887908/the-yin-and-yang-of-nucleic-acid-based-therapy-in-the-brain
#16
REVIEW
Stefano Gustincich, Silvia Zucchelli, Antonello Mallamaci
The post-genomic era has unveiled the existence of a large repertory of non-coding RNAs and repetitive elements that play a fundamental role in cellular homeostasis and dysfunction. These may represent unprecedented opportunities to modify gene expression at the right time in the correct space in vivo, providing an almost unlimited reservoir of new potential pharmacological agents. Hijacking their mode of actions, the druggable genome can be extended to regulatory RNAs and DNA elements in a scalable fashion...
November 22, 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27725193/emerging-therapies-for-neuropathic-lysosomal-storage-disorders
#17
Jessica M Kelly, Allison Bradbury, Douglas R Martin, Mark E Byrne
Approximately 1 in 5000-8000 children are born annually with a lysosomal storage disease (LSD), which affects their cells' ability to break down naturally occurring substrates. Accumulation, or "storage," of undegraded substrates leads to a wide variety of clinical symptoms, and early mortality. Currently, for LSDs with central nervous system (CNS) involvement, there is no available treatment. Four methods of treatment are being explored in clinical trials and preclinical settings: enzyme replacement therapy, ex vivo gene therapy, in vivo gene therapy, and nanoparticle-based therapy...
October 7, 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27713036/insulin-resistance-and-parkinson-s-disease-a-new-target-for-disease-modification
#18
REVIEW
D Athauda, T Foltynie
There is growing evidence that patients with Type 2 diabetes have an increased risk of developing Parkinson's disease and share similar dysregulated pathways suggesting common underlying pathological mechanisms. Historically insulin was thought solely to be a peripherally acting hormone responsible for glucose homeostasis and energy metabolism. However accumulating evidence indicates insulin can cross the blood-brain-barrier and influence a multitude of processes in the brain including regulating neuronal survival and growth, dopaminergic transmission, maintenance of synapses and pathways involved in cognition...
October 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27693252/tdp-43-fus-in-motor-neuron-disease-complexity-and-challenges
#19
REVIEW
Erika N Guerrero, Haibo Wang, Joy Mitra, Pavana M Hegde, Sara E Stowell, Nicole F Liachko, Brian C Kraemer, Ralph M Garruto, K S Rao, Muralidhar L Hegde
Amyotrophic lateral sclerosis (ALS), a common motor neuron disease affecting two per 100,000 people worldwide, encompasses at least five distinct pathological subtypes, including, ALS-SOD1, ALS-C9orf72, ALS-TDP-43, ALS-FUS and Guam-ALS. The etiology of a major subset of ALS involves toxicity of the TAR DNA-binding protein-43 (TDP-43). A second RNA/DNA binding protein, fused in sarcoma/translocated in liposarcoma (FUS/TLS) has been subsequently associated with about 1% of ALS patients. While mutations in TDP-43 and FUS have been linked to ALS, the key contributing molecular mechanism(s) leading to cell death are still unclear...
October 2016: Progress in Neurobiology
https://www.readbyqxmd.com/read/27637159/expanding-the-concept-of-neuroprotection-for-acute-ischemic-stroke-the-pivotal-roles-of-reperfusion-and-the-collateral-circulation
#20
REVIEW
Myron D Ginsberg
This review surveys the efforts taken to achieve clinically efficacious protection of the ischemic brain and underscores the necessity of expanding our purview to include the essential role of cerebral perfusion and the collateral circulation. We consider the development of quantitative strategies to measure cerebral perfusion at the regional and local levels and the application of these methods to elucidate flow-related thresholds of ischemic viability and to characterize the ischemic penumbra. We stress that the modern concept of neuroprotection must consider perfusion, the necessary substrate upon which ischemic brain survival depends...
October 2016: Progress in Neurobiology
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