Stephen J Balevic, Daniel Weiner, Christoph P Hornik, Michael Cohen-Wolkowiez, Daniel Gonzalez, Xiaoming Wang, Meixiang Xu, Sherif Z Abdel-Rahman, Erik Rytting
The use of indomethacin to delay delivery in preterm labor (PTL) is widely accepted; however, the optimal dosage of indomethacin in pregnancy is unknown. Here, we perform population pharmacokinetic (PK) and pharmacodynamic (PD) analyses, characterize the plasma disposition of indomethacin in pregnant women with PTL, and relate indomethacin exposure to delayed delivery and maternal/neonatal safety. We analyzed plasma and urine samples collected from a multicenter, prospective, opportunistic PK/PD study of indomethacin in pregnant women 12-32 weeks gestation admitted with PTL...
February 5, 2024: Journal of Clinical Pharmacology