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Amos Lal, Alwyn Rapose
BACKGROUND: Gonococcal infection can present with wide spectrum of symptoms, most commonly involving the genitals. This case highlights a rare presentation of Neisseria gonorrhoeae infection primarily with skin involvement without uro-genital disease. CASE: A 33-year-old male was admitted to the hospital with complaints of painful swelling of his penis. In the emergency room, he underwent incision and drainage of the abscess under local anaesthesia. After microbiological evaluation, he was found to have skin abscess caused by N...
March 16, 2018: Infection
Carlos Fritzsche, M Loebermann, E C Reisinger
BACKGROUND: Vaccination against hepatitis A virus infection is recommended for men who have sex with men and other risk groups. The protection offered by the combined hepatitis A and B vaccine is comparable to that offered by the monovalent hepatitis A vaccine. CASE: A 38-year-old HIV-positive patient presented with right upper abdominal pain, fever and jaundice. Serological work-up and detection of hepatitis A RNA in stool sample revealed an acute hepatitis A infection despite a previous complete vaccination with the combined hepatitis A and B vaccine...
March 14, 2018: Infection
N Jung, S Rieg
AIMS: Staphylococcus aureus bloodstream infection is one of the most common serious bacterial infections worldwide. It represents a heterogenous clinical entity with a high risk of metastatic complications and a high in-hospital mortality ranging between 20 and 30%. The outcome can be improved by optimised diagnostic and therapeutic management. Thus, our minireview should provide important and often missed pieces of information in the management of S. aureus bloodstream infection. METHODS: We describe the essentials in the management of S...
March 6, 2018: Infection
Christoph D Spinner, Nikola Hanhoff, Ivanka Krznaric, Gaby Knecht, Tim Kuemmerle, Robin Ruesenberg, Knud Schewe
PRUPOSE: To examine current risk behavior, awareness, experience, and attitudes towards pre-exposure-prophylaxis (PrEP), and to estimate a potential impact on the prevention of HIV transmission among HIV-negative MSM in Germany. PrEP was not officially licensed at the time of survey. METHODS: Web-based questionnaire from 03-06/2016. Potential participants were informed through social media, flyers, and advertisements. Risk contacts were defined as unprotected sexual intercourse under the influence of recreational drugs in the past 6 months...
February 24, 2018: Infection
Tatjana Adzic-Vukicevic, Aleksandra Barac, Ana Blanka-Protic, Marija Laban-Lazovic, Bojana Lukovic, Vesna Skodric-Trifunovic, Salvatore Rubino
INTRODUCTION: Non-tuberculous mycobacteria (NTM) are ubiquitous organisms associated with various infections. The aim of the study was to determine the most relevant clinical characteristics of NTM during the 7-year period. METHODOLOGY: A retrospective study of NTM infections was conducted between January 2009 and December 2016. The American Thoracic Society/Infectious Disease Society of America criteria were used to define cases of pulmonary or an extrapulmonary site...
February 23, 2018: Infection
Wenlong Li, James Branley, Archana Sud
PURPOSE: Outpatient parenteral antibiotic therapy (OPAT) is a widely accepted and safe therapeutic option for carefully selected patients. This study reviewed the practice of an OPAT service in a large Australian tertiary teaching hospital in Western Sydney over a 10-year period. METHOD: Data were retrieved from a prospectively maintained electronic database which included information on patient demographics, clinical diagnosis, microbiological identity, antimicrobial therapy, complications and readmissions...
February 20, 2018: Infection
Morgan Hakki, James S Lewis
Multidrug-resistant (MDR) Pseudomonas aeruginosa infection causes significant mortality among patients with hematologic malignancies and hematopoietic-cell transplant recipients. Ceftolozane-tazobactam (C-T) is a novel therapeutic option for MDR-P. aeruginosa infections but clinical experience in these patients is limited. We report favorable clinical outcomes and lack of limiting toxicities using C-T monotherapy to treat invasive MDR-P. aeruginosa infections in these patient populations.
February 19, 2018: Infection
Christoph D Spinner, Christoph Boesecke, Cornelius Jordan, Christoph Wyen, Tim Kümmerle, Gaby Knecht, Stefan Scholten, Alexander Zink, Ivanka Krznaric, Sebastian Noe
PURPOSE: Sexually transmitted infections (STIs) occur frequently in risk populations. Hereby, the role of screening-programmes remains controversial. Our study aimed to determine the prevalence of STI infections in HIV-positive men-who-have-sex-with-men (MSM). METHODS: We enrolled asymptomatic, HIV-MSM in a prospective cross-sectional study from February to August 2016 at seven German HIV-centres. All subjects were screened for Treponema-pallidum (TP) and hepatitis-B/C-infection...
February 19, 2018: Infection
Estelle Rougier, Antoine Braud, Xavier Argemi, Nicolas Lefebvre, Daniel Christmann, Yves Hansmann, Nawal Douiri
INTRODUCTION: Aerococccus urinae (AU) is a pathogen mainly identified in male urinary tract infections and responsible for bacteremia and endocarditis. To the best of our knowledge, there are only five patients with osteomyelitis due to AU described in the literature. All of them had urinary tract disease or systemic conditions such as diabetes, and two were associated with an endocarditis. CASE REPORT: We described the first case of isolated spondylodiscitis without general or local predisposing condition, excepted age > 65 years...
February 16, 2018: Infection
Majdi N Al-Hasan, Avery N Nelson, Julie Ann Justo, Helmut Albrecht, Joseph Kohn, P Brandon Bookstaver
No abstract text is available yet for this article.
February 7, 2018: Infection
Kévin Diallo, Winfried V Kern, Katja de With, Amandine Luc, Nathalie Thilly, Céline Pulcini
INTRODUCTION: Bloodstream infections (BSI) are frequent infections worldwide. Our objective was to explore variation in the management of patients with BSI by infection specialists in France and Germany. METHODS: This work is part of an international ESCMID cross-sectional internet-based questionnaire survey that was opened from December 2016 to February 2017. All hospital-based infection specialists, senior or trainees, giving at least weekly advice on positive blood cultures could participate...
February 3, 2018: Infection
Oscar Murillo, Imma Grau, Joan Gomez-Junyent, Celina Cabrera, Alba Ribera, Fe Tubau, Carmen Peña, Javier Ariza, Roman Pallares
PURPOSE: The relationship between infective endocarditis (IE) and osteoarticular infections (OAIs) are not well known. We aimed to study the characteristics of patients with IE and OAIs, and the interactions between these two infections. METHODS: An observational study (1993-2014) which includes two cohorts: (1) patients with IE (n = 607) and (2) patients with bacteremic OAIs (n = 458; septic arthritis of peripheral and axial skeleton, and vertebral and peripheral osteomyelitis)...
February 2, 2018: Infection
Bettina M Knoll, K Seiter
The introduction of BCR-ABL-tyrosine kinase inhibitors (TKI) for treatment of hematologic malignancies has made a significant impact on patient outcome. Contingent upon their targeted and off-target activity, therapy-associated infectious complications may occur. We present a case of cytomegalovirus pneumonitis and a case of adenovirus hemorrhagic cystitis in two patients with Philadelphia chromosome-positive acute lymphoblastic leukemia on BCR-ABL TKI treatment and review the literature to summarize the infectious complications based on clinical data...
January 31, 2018: Infection
Pamela Kelman, Chelsea Wright Thompson, Wayne Hynes, Christian Bergman, Cameron Lenahan, Joel S Brenner, Michelle G Brenner, Benjamin Goodman, Demetria Borges, Michael Filak, Holly Gaff
BACKGROUND: Infection with Rickettsia parkeri is an emerging tick-borne illness, often accompanied by fever and an eschar at the site of tick attachment. We present three cases of R. parkeri in Virginia residents. CASE PRESENTATIONS: Case 1 presented initially afebrile, failed to seroconvert to rickettsial antigens, and was diagnosed by DNA testing of the eschar. Case 2 presented febrile with eschar, no serologies were performed, and was diagnosed by DNA testing of the eschar...
January 31, 2018: Infection
Kyong-Hee Lee, Kiyozumi Suzuki, Masashi Tsuru, Arifumi Takazawa
No abstract text is available yet for this article.
January 25, 2018: Infection
Emilio Pintor, Benjamín Herreros, Pedro Gargantilla, Maria Jose Gutiérrez
No abstract text is available yet for this article.
January 25, 2018: Infection
Florian Hitzenbichler, Michaela Simon, Thomas Holzmann, Michael Iberer, Markus Zimmermann, Bernd Salzberger, Frank Hanses
PURPOSE: Escherichia coli urine isolates from patients presenting to the emergency department at a German tertiary care hospital were retrospectively analyzed from January 2015-March 2017 to determine antibiotic resistance patterns and patient risk factors for resistance. METHODS: Uncomplicated urinary tract infection (UTI) was defined as UTI in the otherwise healthy patient without relevant co-morbidities and complications. Patients were assumed to have UTI if diagnosis was made by the attending physician with conclusive dipstick results...
January 24, 2018: Infection
Alba Ribera, Laura Soldevila, Raul Rigo-Bonnin, Fe Tubau, Ariadna Padullés, Joan Gómez-Junyent, Javier Ariza, Oscar Murillo
Continuous infusion (CI) of beta-lactams could optimize their pharmacokinetic/pharmacodynamic indices, especially in difficult-to-treat infections. PURPOSE: To validate an easy-to-use method to guide beta-lactams dosage in CI (formula). METHODS: A retrospective analysis was conducted of a prospectively collected cohort (n = 24 patients) with osteoarticular infections caused by Gram-negative bacilli (GNB) managed with beta-lactams in CI. Beta-lactams dose was calculated using a described formula (daily dose = 24 h × beta-lactam clearance × target "steady-state" concentration) to achieve concentrations above the MIC...
January 23, 2018: Infection
Gregorio Di Franco, Enrico Tagliaferri, Erica Pieroni, Edoardo Benedetti, Simone Guadagni, Matteo Palmeri, Niccolò Furbetta, Daniela Campani, Giulio Di Candio, Mario Petrini, Franco Mosca, Luca Morelli
PURPOSE: Invasive aspergillosis (IA) represents a major cause of morbidity and mortality in immunocompromised patients. Involvement of the gastrointestinal tract by Aspergillus is mostly reported as part of a disseminated infection from a primary pulmonary site and only rarely as an isolated organ infection. METHODS: We report a case of small bowel perforation due to IA in a patient with acute leukemia under chemotherapy and pulmonary aspergillosis. We performed a systematic review of the literature as well...
January 22, 2018: Infection
Stamatis Karakonstantis, Dafni Korela, Dimitra Kalemaki
No abstract text is available yet for this article.
January 16, 2018: Infection
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