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https://www.readbyqxmd.com/read/28786004/application-of-the-qsofa-score-to-predict-mortality-in-patients-with-suspected-infection-in-a-resource-limited-setting-in-malawi
#1
Michaëla A M Huson, Chawezi Katete, Lilian Chunda, Jonathan Ngoma, Claudia Wallrauch, Tom Heller, Tom van der Poll, Martin P Grobusch
PURPOSE: To determine the predictive value of qSOFA (quick Sequential Organ Failure Assessment) in Malawian patients with suspected infection. METHODS: Prospective observational study in a tertiary referral hospital in Malawi. RESULTS: Predictive ability of qSOFA was reasonable [AUROC 0.73 (95% CI 0.68-0.78)], increasing to 0.77 (95% CI 0.72-0.82) when classifying all patients with altered mental status as high risk. Adding HIV status as a variable to the qSOFA score did not improve predictive value...
August 7, 2017: Infection
https://www.readbyqxmd.com/read/28786003/erratum-to-respiratory-diphtheria-due-to-corynebacterium-ulcerans-transmitted-by-a-companion-dog-italy-2014
#2
Monica Monaco, Anna Rita Sacchi, Marzia Scotti, Fabiola Mancini, Carlo Riccio, Giulia Errico, Giovanna Ratti, Filippo Bondi, Alessandra Ciervo, Annalisa Pantosti
No abstract text is available yet for this article.
August 7, 2017: Infection
https://www.readbyqxmd.com/read/28779436/outcomes-of-multidrug-resistant-tuberculosis-in-zambia-a-cohort-analysis
#3
Nathan Kapata, Martin P Grobusch, Gershom Chongwe, Pascalina Chanda-Kapata, William Ngosa, Mathias Tembo, Shebba Musonda, Patrick Katemangwe, Matthew Bates, Peter Mwaba, Alimuddin Zumla, Frank Cobelens
PURPOSE: The purpose of this study was to establish a baseline for measuring the impact of the programmatic management of drug-resistant TB program by following up on outcomes of all patients diagnosed with multidrug-resistant tuberculosis in Zambia between 2012 and 2014. METHODS: A cohort study of all the MDR-TB patients diagnosed at the national TB reference laboratory from across Zambia. MDR-TB was diagnosed by culture and DST, whereas outcome data were collected in 2015 by patient record checks and home visits...
August 4, 2017: Infection
https://www.readbyqxmd.com/read/28779435/acute-gastroenteritis-in-primary-care-a-longitudinal-study-in-the-swiss-sentinel-surveillance-network-sentinella
#4
Claudia Schmutz, Philipp Justus Bless, Daniel Mäusezahl, Marianne Jost, Mirjam Mäusezahl-Feuz
PURPOSE: Acute gastroenteritis (AG) leads to considerable burden of disease, health care costs and socio-economic impact worldwide. We assessed the frequency of medical consultations and work absenteeism due to AG at primary care level, and physicians' case management using the Swiss Sentinel Surveillance Network "Sentinella". METHODS: During the 1-year, longitudinal study in 2014, 172 physicians participating in "Sentinella" reported consultations due to AG including information on clinical presentation, stool diagnostics, treatment, and work absenteeism...
August 4, 2017: Infection
https://www.readbyqxmd.com/read/28779434/low-antibodies-titer-and-serological-cross-reaction-between-coxiella-burnetii-and-legionella-pneumophila-challenge-the-diagnosis-of-mediastinitis-an-emerging-q-fever-clinical-entity
#5
Sophie Edouard, Matthieu Million, Jean-Paul Casalta, Frédéric Collart, Bernard Amphoux, Didier Raoult
BACKGROUND: Coxiella burnetii is an intracellular and fastidious bacterium responsible of acute and persistent Q fever infection. Endocarditis and vascular infections are the most common serious complications of acute Q fever. CASE REPORT: We report the case of a 63-year-old man that presented a mediastinitis associated with a prosthetic vascular infection. Serological cross-reaction was observed between Coxiella burnetii, the agent of Q fever, and Legionella pneumophila with higher antibodies titer for L...
August 4, 2017: Infection
https://www.readbyqxmd.com/read/28776165/prolongation-of-the-qtc-interval-in-hiv-infected-individuals-compared-to-the-general-population
#6
Nico Reinsch, Marina Arendt, Marie Henrike Geisel, Christina Schulze, Volker Holzendorf, Anna Warnke, Till Neumann, Norbert H Brockmeyer, Dirk Schadendorf, Lewin Eisele, Raimund Erbel, Susanne Moebus, Karl-Heinz Jöckel, Stefan Esser
OBJECTIVES: Prolonged QT interval is associated with arrhythmias and sudden death. An increased prevalence of QT interval prolongation in human immunodeficiency virus-infected (HIV) subjects was previously described. The impact of different medications and HIV infection itself on the QT interval is rarely investigated in large HIV+ cohorts. METHODS: We compared QT interval measurement in 496 HIV(+) patients of the HIV-HEART study (HIVH) and 992 sex- and age-matched controls of the population-based German Heinz Nixdorf Recall study (HNR)...
August 3, 2017: Infection
https://www.readbyqxmd.com/read/28776164/first-case-of-e-meningoseptica-in-italy-in-a-patient-with-necrotic-hemorrhagic-pancreatitis
#7
Giorgia Montrucchio, Silvia Corcione, Monica Vaj, Teresa Zaccaria, Cristina Costa, Luca Brazzi, Rossana Cavallo, Giovanni Di Perri, Francesco G De Rosa
INTRODUCTION: Elizabethkingia meningoseptica can frequently colonizes the respiratory tract, but its pathogenetic role and its clinical significance are frequently questioned. However, recent data reported E. meningoseptica outbreaks in particular settings, as hospitalized patients. CASE REPORT: We report here the first case of Elizabethkingia meningoseptica infection in Italy in a patient with necrotic-hemorrhagic pancreatitis. E. meningoseptica was isolated from respiratory tract and treated with combination antibiotic therapy...
August 3, 2017: Infection
https://www.readbyqxmd.com/read/28776163/characteristics-of-meningitis-following-transsphenoidal-endoscopic-surgery-a-case-series-and-a-systematic-literature-review
#8
Pasquale Pagliano, Chiara Caggiano, Tiziana Ascione, Domenico Solari, Giusy Di Flumeri, Luigi Maria Cavallo, Fabio Tortora, Paolo Cappabianca
BACKGROUND: Meningitis occurs in 0.8-1.5% of patients undergoing neurosurgery. The aim of the study was to evaluate the characteristics of meningitis after endoscopic endonasal transsphenoidal surgery (EETS) comparing the findings retrieved to those highlighted by literature search. MATERIALS AND METHODS: Patients treated by EETS during an 18-year period in the Department of Neurosurgery of 'Federico II' University of Naples were evaluated and included in the study if they fulfilled criteria for meningitis...
August 3, 2017: Infection
https://www.readbyqxmd.com/read/28766274/pathogen-or-contaminant-distinguishing-true-infection-from-synovial-fluid-culture-contamination-in-patients-with-suspected-septic-arthritis
#9
Mary Louise Fowler, Clara Zhu, Kevin Byrne, Sarah B Lieber, Andrew Moore, Robert H Shmerling, Ziv Paz
BACKGROUND: Isolation of bacteria from synovial fluid (SF) is the gold standard for diagnosis of septic arthritis (SA). Contamination results in misdiagnosis and mismanagement. This study identifies clinical characteristics, microbiology, and outcomes of patients with contaminated SF and compares them with patients with true SA. METHODS: We conducted a retrospective study including all patients aged 18 and older admitted to a single, tertiary-care hospital between 1998 and 2015 with suspected SA and positive SF cultures...
August 1, 2017: Infection
https://www.readbyqxmd.com/read/28762202/verrucous-herpes-of-the-finger-in-a-patient-with-hiv-1-infection
#10
Jose Armando Gonzales Zamora, Luis Alberto Espinoza
No abstract text is available yet for this article.
July 31, 2017: Infection
https://www.readbyqxmd.com/read/28756598/risk-factors-and-predictors-of-mortality-of-candidaemia-among-critically-ill-patients-role-of-antifungal-prophylaxis-in-its-development-and-in-selection-of-non-albicans-species
#11
Matthaios Papadimitriou-Olivgeris, Anastasia Spiliopoulou, Fotini Fligou, Iris Spiliopoulou, Lora Tanaseskou, Georgios Karpetas, Markos Marangos, Evangelos D Anastassiou, Myrto Christofidou
PURPOSE: The aim of the present study is to identify risk factors for development and predictors of mortality of candidaemia among critically ill patients. METHODS: A 1:7 case-control study was conducted during a 4-year period (2012-2015) in a Greek Intensive Care Unit (ICU). Candidaemia was confirmed by positive blood cultures. All yeasts were identified using API 20C AUX System or Vitek 2 Advanced Expert System. Epidemiologic data were collected from the ICU computerized database and patients' chart reviews...
July 29, 2017: Infection
https://www.readbyqxmd.com/read/28726037/can-a-collaborative-subspecialty-antimicrobial-stewardship-intervention-have-lasting-effects
#12
Kaushal B Shah, Ramzy H Rimawi, Mark A Mazer, Paul P Cook
OBJECTIVE: We previously demonstrated the benefit of direct, daily collaboration between infectious disease (ID) and critical care practitioners (CCP) on guideline adherence and antibiotic use in the medical intensive care unit (MICU). In this post-intervention review, we sought to establish whether the effect on antibiotic use and guideline adherence was sustainable. DESIGN: A retrospective review of 87 patients, admitted to the 24-bed MICU, was done 3 (n = 45) and 6 months (n = 42) after the intervention...
July 19, 2017: Infection
https://www.readbyqxmd.com/read/28710682/thelazia-callipaeda-infection-in-a-5-month-old-infant
#13
Xinyue Zhao, Yao Shi, Zhengming Fang, Zhi Wang, Xiaobo Yang
BACKGROUND: Thelazia callipaeda is the main causative organism in thelaziasis, commonly infecting orbital cavities and associated tissues of carnivores. Thelazia callipaeda infection is rarely reported in humans, especially in infants. CASE PRESENTATION: A 5-month-old male infant presented with 2 weeks of redness and increased secretions in the left eye. On examination, the left eye revealed the presence of one creamy thread-like mobile worm in the conjunctival sac...
July 14, 2017: Infection
https://www.readbyqxmd.com/read/28707184/misdiagnosis-of-tuberculosis-associated-with-some-species-of-nontuberculous-mycobacteria-by-genexpert-mtb-rif-assay
#14
Yu Pang, Jie Lu, Biyi Su, Huiwen Zheng, Yanlin Zhao
Out of 12 nontuberculous mycobacteria (NTM) species, 5 were identified as Mycobacterium tuberculosis (MTB) by GeneXpert at a bacterial load of 10(6). Notably, two species, including M. abscessus and M. smegmatis, were flagged as RIF-resistant MTB due to the high C(t) value of Probe E. In conclusion, our data have demonstrated that the misdiagnosis of MTB by GeneXpert assay is observed in five NTM species at a high bacterial load.
July 13, 2017: Infection
https://www.readbyqxmd.com/read/28702763/pharmacokinetics-of-antifungal-drugs-practical-implications-for-optimized-treatment-of-patients
#15
REVIEW
Romuald Bellmann, Piotr Smuszkiewicz
INTRODUCTION: Because of the high mortality of invasive fungal infections (IFIs), appropriate exposure to antifungals appears to be crucial for therapeutic efficacy and safety. MATERIALS AND METHODS: This review summarises published pharmacokinetic data on systemically administered antifungals focusing on co-morbidities, target-site penetration, and combination antifungal therapy. CONCLUSIONS AND DISCUSSION: Amphotericin B is eliminated unchanged via urine and faeces...
July 12, 2017: Infection
https://www.readbyqxmd.com/read/28660356/community-acquired-lower-respiratory-tract-infections-in-hiv-infected-patients-on-antiretroviral-therapy-predictors-in-a-contemporary-cohort-study
#16
Cristiane C Lamas, Lara E Coelho, Beatriz J Grinsztejn, Valdilea G Veloso
Community-acquired pneumonia represents the most frequent bacterial infection in patients with HIV/AIDS. PURPOSE: We aimed to assess variables associated with lower respiratory tract infection (LRTI) among HIV-infected adults using ART. METHODS: A cohort study of HIV-infected patients aged ≥18 years, enrolled from 2000 to 2015, on ART for at least 60 days, with primary outcome as the 1st episode of LRTI during follow-up. The independent variables included were sex at birth, age, race/skin color, educational level, tobacco smoking, alcohol use, cocaine use, diabetes mellitus, CD4 count, HIV viral load, influenza and pneumococcal vaccination...
June 28, 2017: Infection
https://www.readbyqxmd.com/read/28647898/respiratory-diphtheria-due-to-corynebacterium-ulcerans-transmitted-by-a-companion-dog-italy-2014
#17
Monica Monaco, Anna Rita Sacchi, Marzia Scotti, Fabiola Mancini, Carlo Riccio, Giulia Errico, Giovanna Ratti, Filippo Bondi, Alessandra Ciervo, Annalisa Pantosti
A serious respiratory tract infection due to Corynebacterium ulcerans was observed in a 70-year-old woman. Clinical presentation included pseudomembranes in the upper respiratory tract and lung involvement. C. ulcerans was recovered from the nose of the patient's dog. Both dog's and patient's isolates belonged to Sequence Type 331.
June 24, 2017: Infection
https://www.readbyqxmd.com/read/28639141/survival-of-an-aids-patient-after-infection-with-acanthamoeba-sp-of-the-central-nervous-system
#18
Hana El Sahly, Michelle Udayamurthy, George Parkerson, Rodrigo Hasbun
CASE DESCRIPTION: A 38-year-old man presented with headaches and generalized weakness. He was found to have AIDS; a ring-enhancing central nervous system lesion was found on brain imaging and he had elevated serum Toxoplasma gondii IgG levels. A diagnosis of presumptive toxoplasma encephalitis was made and he received antiretrovirals and antitoxoplasma therapy for 4 years. Intermittent headaches and evidence of disease progression on neuroimaging warranted further evaluation and cerebrospinal fluid analysis revealed amebic forms on hematoxylin and eosin staining and positive polymerase chain reaction testing for Acanthamoeba spp...
June 21, 2017: Infection
https://www.readbyqxmd.com/read/28616745/bacterial-meningitis-complicating-the-course-of-liver-cirrhosis
#19
Pasquale Pagliano, Giovanni Boccia, Francesco De Caro, Silvano Esposito
Meningitis is rarely reported in studies investigating bacterial infections in patients affected by liver cirrhosis. We investigated the findings of bacterial meningitis in patients affected by liver cirrhosis referred to our department in a 16-year period. MATERIALS: Patients with cirrhosis and bacterial meningitis were enrolled. Cirrhosis was defined by liver histology or clinical, laboratory, and ultrasonographic and endoscopic findings. Bacterial meningitis was defined by cerebro-spinal fluid pleocytosis (>10/mcl) and characteristic clinical presentation...
June 14, 2017: Infection
https://www.readbyqxmd.com/read/28608225/bacterial-growth-and-antibiotic-resistance-patterns-in-cirrhotic-ascites
#20
LETTER
Jose D Debes, Daniel Beisang, Paola Ricci
No abstract text is available yet for this article.
June 12, 2017: Infection
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