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Herbert Hof, C Juretschke
The number of multi-resistant uropathogens is increasing. A multi-morbid patient developed a symptomatic urinary tract infection with two multi-resistant bacteria, namely Klebsiella pneumoniae and Proteus mirabilis. Nitroxoline was the only drug active against both uropathogens. Obviously, nitroxoline can be an option for the therapy of a urinary tract infection with multi-resistant uropathogens.
November 17, 2018: Infection
Ester Steffens, Charlotte Quintens, Inge Derdelinckx, Willy E Peetermans, Johan Van Eldere, Isabel Spriet, Annette Schuermans
PURPOSE: This narrative review aims to describe barriers of outpatient parenteral antimicrobial therapy at home (OPAT), potentially compromising general standards of antibiotic stewardship (ABS) and facilitators of OPAT for ABS. METHODS: After a literature review, five authors determined the barriers and facilitators to discuss in this review. RESULTS: Sixty-six publications were included in the narrative review and seven barriers and five facilitators are discussed in this article...
November 15, 2018: Infection
Elias Fares, Cindy B McCloskey, Andres Gutierrez, Michael Princiotta, Linda J Salinas, Douglas A Drevets
BACKGROUND: Listeria monocytogenes is a food-borne, facultative intracellular bacterium that causes severe diseases such as sepsis and meningoencephalitis in immunocompromised hosts. Because it stimulates robust T-lymphocyte-mediated responses, attenuated L. monocytogenes are candidate vaccine vectors for tumor immunotherapy. CASE: We report a case of bacteremia caused by vaccine strain L. monocytogenes (Axalimogene filolisbac) occurring 31 months after immunization against human papilloma virus (HPV) associated cervical cancer...
November 14, 2018: Infection
Hideharu Hagiya, Ryohei Kokado, Hideo Okuno, Kazunori Tomono
No abstract text is available yet for this article.
November 14, 2018: Infection
E Tautz, D Wagner, S Wiesemann, A Jonaszik, C Bode, T Wengenmayer, D Staudacher, P Biever, J Hoeppner, D Duerschmied
INTRODUCTION: Broncho-esophageal fistula formation is a rare complication of tuberculosis, most often seen in immunocompromised patients. METHODS AND RESULTS: In this paper, we report the case of a young non-immunocompromised refugee from Somalia diagnosed with open pulmonary tuberculosis complicated by extensive osseous involvement and a broncho-esophageal fistula with consecutive aspiration of gastric contents. The patient rapidly developed a severe acute respiratory distress syndrome (ARDS) requiring venovenous extracorporeal membrane oxygenation (ECMO) therapy for nearly 2 months...
November 11, 2018: Infection
Melanie Stecher, Philipp Schommers, Daniel Schmidt, Christian Kollan, Barbara Gunsenheimer-Bartmeyer, Clara Lehmann, Martin Platten, Gerd Fätkenheuer, Jörg Janne Vehreschild
PURPOSE: The aim of the study was to assess guideline adherence to combined antiretroviral therapy (ART) in the German ClinSurv HIV Cohort and the real-life impact of the Strategic Timing of Antiretroviral Therapy (START) study, to identify patients not treated as recommended by new guidelines. METHODS: We used data from the multicenter ClinSurv cohort of the Robert-Koch-Institute (RKI) between 1999 and 2016. Inclusion criteria were people living with HIV/AIDS, ≥ 18 years of age and cART naïve at the first visit (FV)...
November 9, 2018: Infection
Emma Tippett, Nupur Goyal, Stephen Guy, Jenny Wong
INTRODUCTION: Actinomyces spp. cause several well-described syndromes including cervicofacial and pelvic infections. Actinomyces spp. infection as an opportunistic infection among people who inject drugs has rarely been described with few case reports published. METHODS AND RESULTS: Here we describe four people who inject drugs admitted with Actinomyces spp. infections, all with an overlapping syndrome and who presented a challenge to both diagnose and to manage...
November 8, 2018: Infection
Ariel D Szvalb, Hanine El Haddad, Kenneth V Rolston, Sharjeel H Sabir, Ying Jiang, Issam I Raad, George M Viola
PURPOSE: Percutaneous nephrostomy (PCN) catheters are mainly indicated for urinary tract obstructions. Unfortunately, the rate for infection and recurrence remains elevated. Our objective was to identify the risk factors leading to recurrent PCN-related infections (PCNI) in cancer patients. METHODS: We retrospectively reviewed 571 patients who underwent initial PCN catheter placement at our institution. Of these, we identified patients with a definite PCNI and catheter exchange, with a minimum 30-day follow-up...
November 7, 2018: Infection
Guido Calleri, Andrea Angheben, Marco Albonico
Neglected tropical diseases are becoming more and more frequent in Europe due to the increasing immigration from endemic areas. Nonetheless specific treatments are scarcely available in many European countries, since they are neither officially licensed nor marketed. Only a few referral health centres can afford to access drugs for NTDs due to complex bureaucracy and high cost, importing or providing them via the WHO. Health professionals and institutions in this domain should solicit other stakeholders (such as NGOs, the civil society, scientific societies) to sensitize health authorities to improve access to treatment for such debilitating diseases...
November 2, 2018: Infection
L E Bolton, C Bainbridge
PURPOSE: Pyogenic flexor tenosynovitis (PFT) is recognized as a severe infection of the hand with potentially disastrous outcomes. The mainstay of treatment has been emergent surgical washout. Recent evidence suggests potential for conservative management with a combination of intravenous antibiotics, elevation and splinting. We aim to determine current management of PFT to guide further education and research. METHOD: An electronic survey was distributed to attendees at the Pulvertaft Hand Trauma Symposium in May 2017...
November 1, 2018: Infection
Maurizio Milesi, Claudia Indovina, Ornella Dino, Floriana Di Bella, Francesco Di Lorenzo, Adriana Sanfilippo, Francesca Di Bernardo, Concetta Sodano, Tullio Prestileo
PURPOSE: To understand the frequency of urinary schistosomiasis, in migrants in clinical follow-up at the infectious disease outpatient clinic of ARNAS Civico Hospital in Palermo Italy, to raise awareness on this neglected tropical disease. METHODS: A retrospective analysis of migrant patients in clinical care in our centre during the triennium 2015-2017. RESULTS: 2639 migrants have been in clinical care during the triennium 2015-2017, 72% are male and 28% are female...
October 30, 2018: Infection
Qiang He, Pin Liu, Xuan Li, Kewen Su, Dan Peng, Zhongshuang Zhang, Wei Xu, Zhen Qin, Shuai Chen, Yingli Li, Jingfu Qiu
PURPOSE: Bloodstream infection (BSI) is an important cause of adverse outcomes for recipients with liver transplantation (LT). This meta-analysis aimed to identify risk factors associated with post-LT BSI. METHODS: Relevant studies published up to June 2017 were searched from seven electronic databases. The studies were reviewed according to the inclusion and exclusion criteria. The Z test was used to determine the pooled odds ratio (OR) or standardized mean difference (SMD) of the risk factors...
October 28, 2018: Infection
Arturo Ciccullo, F R Ponziani, E Maiolo, F Pallavicini, M Pompili
BACKGROUND: Hepatitis B virus (HBV) reactivation is commonly observed in HBsAg-positive hematologic patients undergoing immunosuppressive chemotherapy. Recent guidelines recommend antiviral prophylaxis to be continued for up to 12 months after the discontinuation of the anticancer regimen. CASE PRESENTATION: We report a case of a patient who underwent antiviral prophylaxis for 26 months after the discontinuation of a rituximab-containing chemotherapy regimen for a lymphoma and was admitted in the infectious diseases department with a 3-day history of jaundice, itching, and dark urine...
October 27, 2018: Infection
Elsa Prudent, Guillaume Le Guenno, Stijn Jonckheere, Anne Vankeerberghen, Hubert Lepidi, Emmanouil Angelakis, Didier Raoult
BACKGROUND: Immunohistochemistry and Periodic acid-Schiff (PAS) staining have been routinely used for the diagnosis of Whipple's disease (WD). However, these methods present limitations. As a result, the last years, Fluorescence in situ hybridization (FISH) has been increasingly used as a complementary tool for the diagnosis of WD from various tissue samples. CASE REPORT: In this study, we visualized, by FISH, Tropheryma whipplei within macrophages of a lymph node from a patient with WD...
October 27, 2018: Infection
Vincent Ernest, Serge Cammilleri, Philippe Amabile, Mathilde Fedi, Stéphane Burtey, Clarissa Von Kotze, Marion Pelletier, Valérie Moal, Eric Guedj, Cindy Perron, Raafat Boustani, Yvon Berland, Philippe Brunet, Didier Raoult, Pierre-Edouard Fournier, Noémie Jourde-Chiche
Vascular access infection is a frequent complication in hemodialysis patients. We report the second case worldwide of a prosthetic hemodialysis vascular graft infection by Coxiella burnetii, with intense hypermetabolism on PET-CT, Q fever serology consistent with persistent infection, and positive C. burnetii DNA in the blood and removed vascular graft.
October 27, 2018: Infection
Elena Varotto, Roberta Ballestriero
No abstract text is available yet for this article.
October 23, 2018: Infection
Benjamin Lefèvre, Yves Poinsignon, Caroline Piau, François-Charles Javaugue, Jean-Philippe Talarmin, Maeva Lefebvre, Nicolas Varache, Hélène Drouin, Pierre Tattevin
Chronic meningococcemia is defined by blood culture(s) positive for Neisseria meningitidis, symptoms duration > 7 days, and neither meningitis nor shock on admission. This series of 26 consecutive cases illustrates that this is a rare disease (< 5% of meningococcemia, < 0.05 cases per 100,000 inhabitants per year), mostly affecting young adults, males, with no predisposing condition. Major symptoms include fever, rash, and arthralgia. Median time between symptoms onset, and diagnosis is 28 days...
October 19, 2018: Infection
Jiying Xiao, Chenmei Zhang, Sheng Ye
INTRODUCTION: The incidence of Acinetobacter baumannii meningitis, which typically occurs after neurosurgery, has increased in recent years. Pediatric Acinetobacter baumannii meningitis due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has important clinical significance. METHODOLOGY: We retrospectively reviewed the clinical course and outcome of nine cases of meningitis due to Acinetobacter baumannii in children and reviewed the relevant literature...
October 16, 2018: Infection
Hariom Soni, Balaji L Bellam, Raghavendra K Rao, Praveen M Kumar, Harshal S Mandavdhare, Harjeet Singh, Usha Dutta, Vishal Sharma
BACKGROUND: The role of adjunctive steroids in abdominal tuberculosis is unclear. OBJECTIVE: To evaluate effect of adjunctive use of steroids for abdominal tuberculosis in reducing/preventing complications. METHODS: We searched electronic databases (Medline, Embase, CENTRAL, Scopus, Web of Science, CINAHL) from inception to 25th June 2018 using the terms "abdominal tuberculosis" OR "intestinal tuberculosis" OR "peritoneal tuberculosis" OR "tuberculous peritonitis" AND steroids OR methylprednisolone OR prednisolone...
October 15, 2018: Infection
Johannes R Bogner
No abstract text is available yet for this article.
October 11, 2018: Infection
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