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https://www.readbyqxmd.com/read/29785614/cascade-of-care-and-factors-associated-with-virological-suppression-among-hiv-positive-persons-linked-to-care-in-the-test-and-keep-in-care-tak-project
#1
Justyna D Kowalska, Magdalena Ankiersztejn-Bartczak, Leah Shepherd, Amanda Mocroft
INTRODUCTION: Early treatment remains the most effective HIV prevention strategy; poor linkage to care after HIV diagnosis may compromise this benefit. We sought to better understand patient characteristics and their association with virological suppression (VS) following cART initiation. METHODS: The TAK project collects pre-linkage to care and clinical data on patients diagnosed with HIV in voluntary testing facilities in central Poland. Data collected for persons diagnosed in 2010-2013 were linked with HIV clinic records...
May 21, 2018: Infection
https://www.readbyqxmd.com/read/29785613/neuroinfections-caused-by-fungi
#2
REVIEW
Katarzyna Góralska, Joanna Blaszkowska, Magdalena Dzikowiec
BACKGROUND: Fungal infections of the central nervous system (FIs-CNS) have become significantly more common over the past 2 decades. Invasion of the CNS largely depends on the immune status of the host and the virulence of the fungal strain. Infections with fungi cause a significant morbidity in immunocompromised hosts, and the involvement of the CNS may lead to fatal consequences. METHODS: One hundred and thirty-five articles on fungal neuroinfection in PubMed, Google Scholar, and Cochrane databases were selected for review using the following search words: "fungi and CNS mycoses", CNS fungal infections", "fungal brain infections", " fungal cerebritis", fungal meningitis", "diagnostics of fungal infections", and "treatment of CNS fungal infections"...
May 21, 2018: Infection
https://www.readbyqxmd.com/read/29767394/prognostic-factors-and-scoring-model-of-hematological-malignancies-patients-with-bloodstream-infections
#3
Yishu Tang, Qian Cheng, Qing Yang, Jing Liu, Di Zhang, Wei Cao, Qingxia Liu, Tianyi Zhou, Huiqi Zeng, Li Zhou, QinJin Wang, Huan Wei, Xin Li
PURPOSE: Patients with hematological malignancies (HMs) are at a higher risk for bloodstream infections (BSIs), which pose significant burden on morbidity and mortality. Better risk stratification helps in medical decision making, increasing efficiency and reducing economic burden. The aim of this study was to develop and validate a reliable prediction model which can be used to identify HM patients at higher risk for BSIs. METHODS: We conducted a retrospective cohort study in three university-affiliated hospitals in Hunan Province, China, from January 2010 to April 2015...
May 16, 2018: Infection
https://www.readbyqxmd.com/read/29766472/epidemiology-management-and-outcome-of-varicella-in-pregnancy-a-20-year-experience-at-the-tuscany-reference-centre-for-infectious-diseases-in-pregnancy
#4
Michele Trotta, Beatrice Borchi, Alessandra Niccolai, Elisabetta Venturini, Susanna Giaché, Gaetana Sterrantino, Maria Grazia Colao, Gian Maria Rossolini, Alessandro Bartoloni, Lorenzo Zammarchi
Data from 215 pregnant women exposed to varicella and 276 with varicella observed at the Tuscany Reference Center for Infectious Diseases in Pregnancy, Florence, Italy, in the period 1997-2016 were retrospectively collected. The risk of developing varicella was lower in exposed women who received varicella zoster immunoglobulin compared with those who did not receive it [42% (21 of 50) vs 72% (13 of 18); p = 0.0263]. Typical congenital varicella syndrome was observed in 1.56% of fetuses/neonates born from pregnant women with varicella...
May 15, 2018: Infection
https://www.readbyqxmd.com/read/29752649/risk-factors-for-pneumonia-due-to-beta-lactam-susceptible-and-beta-lactam-resistant-pseudomonas-aeruginosa-a-case-case-control-study
#5
Mohammed J Al-Jaghbeer, Julie Ann Justo, William Owens, Joseph Kohn, P Brandon Bookstaver, Jennifer Hucks, Majdi N Al-Hasan
PURPOSE: This case-case-control study aims to identify clinical predictors for pneumonia due to Pseudomonas aeruginosa (PA) which is (1) susceptible to all routinely tested antipseudomonal beta-lactams (APBL-S) and (2) resistant to at least one antipseudomonal beta-lactam (APBL-R). METHODS: Hospitalized adults with acute bacterial pneumonia at Palmetto Health hospitals in Columbia, SC, USA from January 1, 2012 to April 15, 2014 were identified. Multivariate logistic regression was used to determine risk factors for pneumonia due to APBL-S PA and APBL-R PA...
May 11, 2018: Infection
https://www.readbyqxmd.com/read/29752648/human-cystic-echinococcosis-in-hungary-2000-2014-a-retrospective-case-series-analysis-from-a-single-center-study
#6
Balázs Dezsényi, Áron Somorácz, József Danka, István Kucsera, Thomas F E Barth, Adriano Casulli
PURPOSE: Cystic echinococcosis (CE) is a parasitic disease caused by the tapeworm Echinococcus granulosus sensu lato. Although in Hungary the disease is listed among reportable infections, inadequacies in the reporting practice of CE by clinicians and pathologists have resulted in underscoring of this disease. The aim of this study was to describe the epidemiological and clinical characteristics of CE in Hungary using a datasource other than the official records that are based mainly on serological data...
May 11, 2018: Infection
https://www.readbyqxmd.com/read/29748841/characteristics-of-pulmonary-mucormycosis-and-predictive-risk-factors-for-the-outcome
#7
Jun Feng, Xuefeng Sun
PURPOSE: Little is known about risk factors for the outcome of pulmonary mucormycosis. We summarized characteristics of this rare disease, and systemically explored risk factors for the outcome. METHODS: Ninety-two patients with pulmonary mucormycosis, including 12 patients at Peking Union Medical College Hospital and 80 patients published in 62 articles between 2006 and 2016, were retrospectively analyzed. RESULTS: The median age was 47.5 years, and the male to female ratio was 2...
May 10, 2018: Infection
https://www.readbyqxmd.com/read/29748840/clinical-patterns-epidemiology-and-risk-factors-of-community-acquired-urinary-tract-infection-caused-by-extended-spectrum-beta-lactamase-producers-a-prospective-hospital-case-control-study
#8
Basima A Almomani, Wail A Hayajneh, Abeer M Ayoub, Mera A Ababneh, Miral A Al Momani
PURPOSE: To assess incidence rate, risk factors and susceptibility patterns associated with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae in community-acquired urinary tract infections (CA-UTIs). METHODS: A prospective, case-control study was conducted at a tertiary teaching hospital from Jan 2015 to Dec 2016. The results of microbiology cultures were initially screened to include only patients with positive E. coli or K...
May 10, 2018: Infection
https://www.readbyqxmd.com/read/29737456/disseminated-nocardiosis-caused-by-nocardia-elegans-a-case-report-and-review-of-the-literature
#9
Yi You, Wenchief Chen, Baiyu Zhong, Ziqiang Song, Xichuan Yang
BACKGROUND: Disseminated nocardiosis is a rare disease mostly occurring in immunocompromised patients. METHODS: We report a case of disseminated nocardiosis in a diabetic patient with both pulmonary and cutaneous involvement. Nocardia elegans was isolated and identified using the 16s ribosomal RNA gene sequence data. RESULTS: Clinical improvement was observed within 3 months after initiation of antimicrobial treatment with oral doxycycline, trimethoprim-sulfamethoxazole and intravenous penicillin, but the patient died 5 months later after arbitrary discontinuation of the treatment...
May 8, 2018: Infection
https://www.readbyqxmd.com/read/29736856/the-field-is-moving-on-new-diagnostic-and-therapeutic-tools-presented-at-the-28th-eccmid-2018
#10
EDITORIAL
Johannes R Bogner
No abstract text is available yet for this article.
May 7, 2018: Infection
https://www.readbyqxmd.com/read/29728837/bacterial-etiology-of-soft-tissue-infections
#11
LETTER
Tanja Schülin
No abstract text is available yet for this article.
May 4, 2018: Infection
https://www.readbyqxmd.com/read/29725938/gamma-delta-t-cell-expansion-in-whipple-s-disease-with-muscular-granulomatous-vasculitis
#12
Didier Brönnimann, Marie-Anne Vandenhende, Jean-François Viallard
Whipple's disease usually presents as chronic joint pain followed by digestive manifestations. However, many different presentations have been described in the literature. We report here the first proven case of muscular vasculitis related to Whipple's disease, associated with an expansion of circulating activated γδ T lymphocytes.
May 3, 2018: Infection
https://www.readbyqxmd.com/read/29687315/incidental-intraoperative-diagnosis-of-mycobacterium-abscessus-meningeal-infection-a-case-report-and-review-of-the-literature
#13
REVIEW
Francesca Giovannenze, Vito Stifano, Giancarlo Scoppettuolo, Fernando Damiano, Federico Pallavicini, Giovanni Delogu, Ivana Palucci, Alessandro Rapisarda, Cosimo Sturdà, Angelo Pompucci
PURPOSE: Mycobacterium abscessus, and rapidly growing mycobacteria in general, are rare but increasing causes of central nervous system (CNS) infections. The aim of this study is to highlight the importance of considering these microorganism in the differential diagnosis of CNS infections, obtaining a prompt diagnosis, and improving clinical outcomes. METHODS: Case report and literature review. RESULTS: We report a case of meningeal infection in a patient who underwent decompressive craniectomy after a craniofacial trauma...
April 23, 2018: Infection
https://www.readbyqxmd.com/read/29667040/management-of-superficial-and-deep-seated-staphylococcus-aureus-skin-and-soft-tissue-infections-in-sub-saharan-africa-a-post-hoc-analysis-of-the-staphnet-cohort
#14
Abraham Alabi, Theckla Kazimoto, Marthe Lebughe, Delfino Vubil, Patrick Phaku, Inacio Mandomando, Winfried V Kern, Salim Abdulla, Alexander Mellmann, Lena Peitzmann, Markus Bischoff, Georg Peters, Mathias Herrmann, Martin P Grobusch, Frieder Schaumburg, Siegbert Rieg
PURPOSE: The incidence of Staphylococcus aureus skin and soft tissue infection (SSTI) is high in sub-Saharan Africa. This is fueled by a high prevalence of Panton-Valentine leukocidin (PVL), which can be associated with necrotizing disease. The aim was to describe the clinical presentation and the treatment of SSTI in the African setting and to identify challenges in the management. METHODS: Patients (n = 319) were recruited in DR Congo (n = 56, 17.6%), Gabon (n = 89, 27...
April 17, 2018: Infection
https://www.readbyqxmd.com/read/29654496/evaluation-of-candidemia-and-antifungal-consumption-in-a-large-tertiary-care-italian-hospital-over-a-12-year-period
#15
Jessica Mencarini, Elisabetta Mantengoli, Lorenzo Tofani, Eleonora Riccobono, Rossella Fornaini, Filippo Bartalesi, Giampaolo Corti, Alberto Farese, Patrizia Pecile, Luca Boni, Gian Maria Rossolini, Alessandro Bartoloni
PURPOSE: An early adequate antifungal therapy based on the knowledge of local epidemiology can reduce the candidemia-attributable mortality and the length of hospitalization. We performed a retrospective study to analyze the epidemiology of candidemia and the antifungal consumption in our hospital. METHODS: We analyzed Candida spp. isolated from the blood, and their susceptibility profile from 2005 to 2016 in Careggi University Hospital, Florence, Italy. We also performed a stratified analysis by clinical setting where Candida spp...
April 13, 2018: Infection
https://www.readbyqxmd.com/read/29627936/invasive-fungal-infections-associated-with-prior-respiratory-viral-infections-in-immunocompromised-hosts
#16
Saira Ajmal, Maryam Mahmood, Omar Abu Saleh, Jenifer Larson, M Rizwan Sohail
BACKGROUND: Increased risk of invasive pulmonary aspergillosis after influenza infection has been reported; however data are limited. PURPOSE: To describe Invasive fungal infections (IFI) associated with preceding respiratory viral infection at a large referral center. METHODS: We reviewed all IFI cases among patients with positive influenza and/or RSV nasopharyngeal/lower respiratory tract PCR from October 2015 to December 2016. Cases of pulmonary IFI were classified as possible, probable, and definite based on EORTC-MSG definitions...
April 7, 2018: Infection
https://www.readbyqxmd.com/read/29616458/notifiable-infectious-diseases-in-refugees-and-asylum-seekers-experience-from-a-major-reception-center-in-munich-germany
#17
Martin Alberer, Svea Malinowski, Linda Sanftenberg, Jörg Schelling
PURPOSE: In 2016, the number of refugees worldwide reached 65.6 million. So far, only limited data are available on the health status of refugees and asylum seekers (RAs). Especially, notifiable infectious diseases (NIDs) carry the risk of outbreaks in communal accommodations hosting RAs. METHODS: We conducted a monocentric retrolective cross-sectional study including 15,137 RAs treated in a special health care unit for RAs located in the major reception center in Munich from November 2014 to October 2016...
April 3, 2018: Infection
https://www.readbyqxmd.com/read/29600444/serum-ykl-40-as-a-biomarker-for-liver-fibrosis-in-chronic-hepatitis-b-patients-with-normal-and-mildly-elevated-alt
#18
Linlin Yan, Yongqiong Deng, Jiyuan Zhou, Hong Zhao, Guiqiang Wang
PURPOSE: YKL-40 is a chitinase-like protein expressed in multiple tissues including liver and is reported as a fibrosis marker. This study aimed to determine whether YKL-40 could serve as a diagnostic marker for the assessment of liver fibrosis in chronic hepatitis B patients with normal and mildly elevated ALT. METHODS: Six hundred and eighty-five patients with chronic hepatitis B infection were enrolled in this study from October 2013 to March 2016. All patients underwent liver biopsy and then staged based on Ishak histological system...
March 29, 2018: Infection
https://www.readbyqxmd.com/read/29594953/ceftolozane-tazobactam-for-the-treatment-of-xdr-pseudomonas-aeruginosa-infections
#19
Laura Escolà-Vergé, Carles Pigrau, Ibai Los-Arcos, Ángel Arévalo, Belen Viñado, David Campany, Nieves Larrosa, Xavier Nuvials, Ricard Ferrer, Oscar Len, Benito Almirante
PURPOSE: The aim of this study was to evaluate the effectiveness of ceftolozane/tazobactam (C/T) for treating extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) infections, and to analyze whether high C/T dosing (2 g ceftolozane and 1 g tazobactam every 8 h) and infection source control have an impact on outcome. METHODS: Retrospective study of all consecutive patients treated with C/T for XDR-PA infection at a tertiary referral hospital (November 2015-July 2017)...
March 28, 2018: Infection
https://www.readbyqxmd.com/read/29556979/is-fluoroquinolone-monotherapy-a-useful-alternative-treatment-for-pseudomonas-aeruginosa-bacteraemia
#20
Ping-Feng Wu, Yi-Tsung Lin, Fu-Der Wang, Tsuey-Ching Yang, Chang-Phone Fung
PURPOSE: Pseudomonas aeruginosa bacteraemia is associated with high mortality, and most monotherapies are beta-lactam-based. We aimed to investigate clinical outcomes of definitive fluoroquinolone monotherapy versus beta-lactam monotherapy for P. aeruginosa bacteraemia. METHODS: This retrospective study enrolled adult patients receiving definitive monotherapy with beta-lactam or fluoroquinolone between November 2013 and November 2014 at Taipei Veterans General Hospital...
March 20, 2018: Infection
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