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Emanuela Zappulo, Laura Ambra Nicolini, Carmen Di Grazia, Alida Dominietto, Teresa Lamparelli, Francesca Gualandi, Patrizia Caligiuri, Bianca Bruzzone, Emanuele Angelucci, Claudio Viscoli, Malgorzata Mikulska
PURPOSE: Hepatitis B virus (HBV) reactivation during immunosuppressive therapy is common in patients with hematological malignancies, even in case of resolved infection. Prophylaxis of HBV reactivation is universally recommended in stem cell transplant (SCT) recipients and patients treated with anti-CD20 agents (i.e., rituximab). Despite its well-established favorable safety profile, lamivudine (LAM) use in prophylaxis has been debated because of the possible emergence of resistant viral strains...
September 19, 2018: Infection
Philipp Koehler, Norma Jung, Matthias Kochanek, Philipp Lohneis, Alexander Shimabukuro-Vornhagen, Boris Böll
INTRODUCTION: Staphylococcus aureus frequently causes infections in outpatient and hospital settings and can present as a highly variable entity. Typical manifestations are endocarditis, osteoarticular infections or infection of implanted prostheses, intravascular devices or foreign bodies. A thorough diagnostic evaluation with early focus identification is mandatory to improve patient outcome. CASE REPORT: We report a case of a 68-year old patient with a history of double allogeneic stem cell transplant for acute myeloid leukemia who developed a S...
September 18, 2018: Infection
Andreas Schönfeld, B Jensen, H M Orth, D Tappe, T Feldt, D Häussinger
Clinical presentation of leptospirosis ranges from asymptomatic infection to fulminant, life-threatening disease. Pulmonary involvement in terms of severe pulmonary haemorrhage syndrome (SPHS) has recently become a more frequently reported facet of leptospirosis and correlates with high mortality rates. It has not yet been described in returning German travellers. We present a case of a healthy young man developing massive pulmonary haemorrhage and severe ARDS requiring mechanical ventilation and high-dose catecholamines after travelling to Indonesia...
September 18, 2018: Infection
Julian Schmidberger, Henriette Weimer, Patrycja Schlingeloff, Wolfgang Kratzer, Beate Grüner
PURPOSE: The Alveolar echinococcosis (AE) is a rare zoonosis caused by the parasite Echinococcus multilocularis. To date, nothing is known about the health-related quality of life (HRQoL) in patients with AE. The aim of the study was to evaluate the HRQoL in patients with AE in comparison of the healthy population. METHODS: We used the 36-Item Short Form Health Survey (SF-36) questionnaire to evaluate the HRQoL. The SF-36 scales have a range of 0-100 (0 represents the worst and 100 the most favourable state of health)...
September 17, 2018: Infection
Marcin F Osuchowski, Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H Chaudry, Craig M Coopersmith, Clifford Deutschman, Susanne Drechsler, Philip Efron, Claes Frostell, Gerhard Fritsch, Waldemar Gozdzik, Judith Hellman, Markus Huber-Lang, Shigeaki Inoue, Sylvia Knapp, Andrey V Kozlov, Claude Libert, John C Marshall, Lyle L Moldawer, Peter Radermacher, Heinz Redl, Daniel G Remick, Mervyn Singer, Christoph Thiemermann, Ping Wang, W Joost Wiersinga, Xianzhong Xiao, Basilia Zingarelli
The original version of this article unfortunately contained mistakes.
September 17, 2018: Infection
Sibylle C Mellinghoff, O A Cornely, N Jung
AIMS: Due to the increase of severely immunocompromised patients, of invasive procedures including central intravascular catheters, and of the use of broad-spectrum antibiotics, the incidence of Candida bloodstream infections has risen intensely in the last decades. Candida bloodstream infection is a serious disease with high mortality. Optimized diagnostic and therapeutic management can improve outcome. Thus, the aim of our mini-review is to highlight important and often missed opportunities in the management of Candida bloodstream infection...
September 14, 2018: Infection
Saeed El Zein, Jean El-Sheikh, Aline Zakhem, Dima Ibrahim, Ali Bazarbachi, Souha S Kanj
The spelling of the name "Ali Bazarbachi" was incorrect.
September 14, 2018: Infection
(no author information available yet)
No abstract text is available yet for this article.
September 14, 2018: Infection
Matthaios Papadimitriou-Olivgeris, Anastasia Spiliopoulou, Fevronia Kolonitsiou, Christina Bartzavali, Anastasia Lambropoulou, Panagiota Xaplanteri, Evangelos D Anastassiou, Markos Marangos, Iris Spiliopoulou, Myrto Christofidou
PURPOSE: The aim of the present study was to analyze candidaemia's epidemiology (incidence, species distribution, and susceptibility rates) and antifungal consumption during a 9-year period. METHODS: All candidaemias recorded at The University General Hospital of Patras, Greece, between 2009 and 2017 were included. Candida isolates were identified using the germ tube test, API 20C AUX System, and/or Vitek-2 YST card. Antifungal susceptibility was determined by the gradient method according to CLSI...
September 8, 2018: Infection
E Forsblom, A Kakriainen, E Ruotsalainen, A Järvinen
BACKGROUND: Sex-related treatment inequalities are suggested to explain outcome differences between men and women in Staphylococcus aureus bacteremia (SAB). We compared patient characteristics, clinical management, infectious specialist consultation (ISC) and outcome in men and women with SAB. METHODS: Multicenter retrospective study of methicillin-sensitive (MS-) SAB patients categorized according to sex and ISC consultation provided within 7 days of diagnosis...
September 7, 2018: Infection
Aurélie Baldolli, Nicolas Martin Silva, Amélie Seguin, Gwenola Maigne, Audrey Sultan, Samuel Deshayes, Damien Du Cheyron, Aurélie Joret, Nizar Mahlaoui, Boris Bienvenu
BACKGROUND: Primary immunodeficiency (PID) in adults is rare and mostly revealed by infections. MATERIAL AND METHODS: Adults without predisposing factors who were admitted to an intensive care unit (ICU) for infection were screened for PID. RESULTS: Six PID cases were diagnosed, mostly revealed by encapsulated bacterial infections. CONCLUSION: Investigation of PID after ICU discharge should be considered to improve early detection...
September 7, 2018: Infection
Balint Gergely Szabo, Katalin Szidonia Lenart, Tamas Tirczka, Eszter Ostorhazi
To describe the characteristics of adult invasive H. influenzae disease, 34 patients diagnosed at a single tertiary center between 2004 and 2017 were analyzed in a retrospective case series study. The annual estimated incidence was 0.1 cases/100.000 inhabitants. Dominant source of infection was pneumonia accompanied by sepsis (62%) and caused by nontypeable strains (74%) with low ampicillin resistance (14%). Survival (94%) and complication rates were high (35%). Main empirical treatments were ceftriaxone or levofloxacine...
September 6, 2018: Infection
Tatsuya Shindo, Hiroaki Nishioka
No abstract text is available yet for this article.
September 6, 2018: Infection
G R Rahim, Neha Gupta
No abstract text is available yet for this article.
September 5, 2018: Infection
Enrico Schalk, Vanja Zeremski, Thomas Fischer
No abstract text is available yet for this article.
September 5, 2018: Infection
Anna Eichinger, Alexandra Hagen, Melanie Meyer-Bühn, Johannes Huebner
BACKGROUND: Sepsis-like illness with suspected meningitis or encephalitis is a common reason for using empiric antimicrobial therapy in infants and children. However, in cases of viral meningitis not covered by these antimicrobials, this management is ineffective and due to side effects potentially harmful. METHODS: A retrospective analysis of cerebrospinal fluid (CSF) multiplex PCRs (Biofire FilmArray® ) in children with clinical suspicion of meningitis, encephalitis or sepsis-like illness was performed over the period of 1 year...
September 5, 2018: Infection
Andreas Berge, Andrea Krantz, Helena Östlund, Pontus Nauclér, Magnus Rasmussen
OBJECTIVES: Enterococcal bacteremia can be complicated by infective endocarditis (IE) and when suspected, transesophageal echocardiography (TEE) should be performed. The previously published NOVA score can identify patients with enterococcal bacteremia at risk for IE and we aimed to improve the score. METHODS: Factors associated with IE were studied retrospectively in a population-based cohort of patients with monomicrobial Enterococcus faecalis bacteremia (MEFsB)...
September 3, 2018: Infection
Maria J G T Vehreschild, Miriam Haverkamp, Lena M Biehl, Sebastian Lemmen, Gerd Fätkenheuer
In recent years, an increase in invasive VRE infections has been reported worldwide, including Germany. The most common gene encoding resistance to glycopeptides is VanA, but predominant VanB clones are emerging. Although neither the incidence rates nor the exact routes of nosocomial transmission of VRE are well established, screening and strict infection control measures, e.g. single room contact isolation, use of personal protective clothing by hospital staff and intensified surface disinfection for colonized individuals, are implemented in many hospitals...
September 3, 2018: Infection
Tomislav Meštrović
Corynebacterium glucuronolyticum is a rare and neglected, but increasingly recognized bacterial agent of infectious urethritis and other genitourinary syndromes in men. This is the first description of its proclivity to resurface as a cause of sustained urethritis in male patients previously treated for Chlamydia trachomatis, which represents a phenomenon that has to be differentiated from a simple post-treatment overgrowth of a colonizing agent.
August 30, 2018: Infection
Shouci Hu, Ren Tong, Yang Bo, Pei Ming, Hongtao Yang
PURPOSE: Fungal peritonitis (FP) is a rare but devastating complication in peritoneal dialysis (PD), accounting for high rates of technique failure, morbidity and mortality. This study was conducted to investigate FPs with regard to peritonitis rate, microbiology testing, patient characteristics, clinical features, antifungal treatments, and clinical outcomes in patients on PD. METHODS: This single-center study retrospectively reviewed all FP episodes diagnosed from June 1, 2012 to June, 2017...
August 25, 2018: Infection
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