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Intervirology

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https://www.readbyqxmd.com/read/28910810/concurrent-infection-with-plasmodium-vivax-and-the-dengue-and-chikungunya-viruses-in-a-paediatric-patient-from-new-delhi-india-in-2016
#1
Ayesha Tazeen, Mohd Abdullah, Malik Hisamuddin, Sher Ali, Irshad H Naqvi, Hirday N Verma, Anwar Ahmed, Shama Parveen
Dengue and chikungunya fevers are transmitted by the common mosquito vector Aedes and malaria by Anopheles. Concurrent infections are reported due to co-circulation of these pathogens, especially in endemic regions. We report a rare case of triple infection with 3 arthropod-borne pathogens (Plasmodium vivax and the dengue and chikungunya viruses) in a 3-year-old child from New Delhi, India, in August 2016. The viruses were identified by RT-PCR and the parasite by microscopy and antigen detection. The dengue virus serotype 3 sequence was clustered in the genotype III by the phylogenetic analysis...
September 15, 2017: Intervirology
https://www.readbyqxmd.com/read/28877517/the-histopathological-characteristics-caused-by-trionyx-sinensis-hemorrhagic-syndrome-virus-tshsv-and-comparative-proteomic-analysis-of-liver-tissue-in-tshsv-infected-chinese-soft-shelled-turtles-pelodiscus-sinensis
#2
Li Liu, Zheng Cao, Feng Lin, Xueping Ye, Shujuan Lu, Sunjian Lyv
Trionyx sinensis hemorrhagic syndrome virus (TSHSV) is a pathogen that causes severe hemorrhagic syndrome and irreversible damage to different infected tissues of Pelodis cus sinensis, ending in the death of affected organisms. In the present study, the histopathological characteristics of TSHSV-infected P. sinensis were analyzed and compared by HE staining. Relative and absolute quantification (iTRAQ)-based proteomic analysis was employed to explore the molecular pathology of liver injury. Anatomical features indicated that TSHSV caused obvious congestion in the liver, kidney, intestine, and other tissues of P...
September 7, 2017: Intervirology
https://www.readbyqxmd.com/read/28869960/syncytia-induction-by-clinical-isolates-of-human-respiratory-syncytial-virus-a
#3
Talita Bianca Gagliardi, Miriã Ferreira Criado, José Luiz Proença-Módena, Ariane Mirela Saranzo, Marisa Akiko Iwamoto, Flávia Escremim de Paula, Ricardo Souza Cardoso, Luana Sela Delcaro, Maria Lúcia Silva, Ataide Ademir Câmara, Eurico Arruda
OBJECTIVE: Syncytia formation is the hallmark of the cytopathic effect caused by human respiratory syncytial virus (HRSV), which is the most important viral respiratory pathogen in children. This article reports methodological improvements in primary HRSV isolation and the importance of syncytia formation and mRNA levels of F protein for the progeny yield, using clinical isolates of HRSV. METHODS: The A and B strains of HRSV were isolated in HEp-2 cell cultures from fresh and frozen nasopharyngeal aspirates...
September 5, 2017: Intervirology
https://www.readbyqxmd.com/read/28869941/identifying-attenuating-mutations-tools-for-a-new-vaccine-design-against-flaviviruses
#4
Cécile Khou, Nathalie Pardigon
Emerging Flaviviruses pose an increasing threat to global human health. To date, human vaccines against yellow fever virus (YFV), Japanese encephalitis virus (JEV), dengue virus (DV), and tick-borne encephalitis virus (TBEV) exist. However, there is no human vaccine against other Flaviviruses such as Zika virus (ZIKV) and West Nile virus (WNV). In order to restrict their spread and to protect populations against the diseases they induce, vaccines against these emerging viruses must be designed. Obtaining new live attenuated Flavivirus vaccines using molecular biology methods is now possible...
September 5, 2017: Intervirology
https://www.readbyqxmd.com/read/28848176/transformation-of-cells-by-photoinactivated-murine-gamma-herpesvirus-68-during-nonproductive-and-quiescent-infection
#5
Veronika Mrázová, Marcela Kúdelová, Miroslava Smolinská, Eva Nováková, Miroslava Šupolíková, Michaela Vrbová, František Golais
Infection of human MRC-5 cells and mouse NIH-3T3 cells with a murine gamma-herpesvirus (MuHV-4 strain 68; MHV-68) photoinactivated by visible light in the presence of methylene blue (MB) resulted in nonproductive infection and the appearance of morphologically transformed cells. Two stably transformed cell lines were derived from both of these cell types and were confirmed to contain both viral DNA and antigen. Next, a quiescent MHV-68 infection in MRC-5 and NIH-3T3 cells was established after cultivation at 41°C in the presence of phosphonoacetic acid...
August 25, 2017: Intervirology
https://www.readbyqxmd.com/read/28848124/detection-of-merkel-cell-polyomavirus-in-respiratory-tract-specimens
#6
Evelina Shikova, Djanan Emin, Dora Alexandrova, Mihail Shindov, Аntoniya Kumanova, Andrey Lekov, Ugo Moens
OBJECTIVE: The role of Merkel cell polyomavirus (MCPyV) as a respiratory pathogen is controversial. The aim of this study was to determine the prevalence of MCPyV in patients with acute respiratory diseases and chronic lung diseases, including lung cancer, in order to evaluate the association between MCPyV infection and respiratory diseases. METHODS: This study included 221 specimens (133 nasopharyngeal swabs and 88 lung biopsy specimens) obtained from patients with acute respiratory diseases and chronic lung diseases, including lung cancer...
August 25, 2017: Intervirology
https://www.readbyqxmd.com/read/28813716/no-correlation-of-the-disease-severity-of-influenza-a-virus-infection-with-the-rs12252-polymorphism-of-the-interferon-induced-transmembrane-protein-3-gene
#7
Yong-Chan Kim, Byung-Hoon Jeong
The 2009 H1N1 influenza pandemic, which involved a more pathogenic virus than seasonal influenza viruses, rapidly spread around the world and caused many deaths in humans. The members of the interferon-induced transmembrane (IFITM) protein family prevent viral replication and are crucial for defending the host cell against influenza A virus (IAV). Several studies suggest that the CC genotype at the single nucleotide polymorphism (SNP) rs12252 of IFITM3 confers a genetic predisposition to pandemic influenza A in Europeans and Han Chinese, although one study in a British cohort failed to show an association...
August 17, 2017: Intervirology
https://www.readbyqxmd.com/read/28795954/the-first-characterization-of-hiv-1-subtypes-and-drug-resistance-mutations-among-antiretrovirally-treated-patients-in-kermanshah-iran
#8
Reza Golmohammadi, Kazem Baesi, Abdolvahab Moradi, Molood Farrokhi, Willi McFarland, Shahryar Parsamajd
BACKGROUND: Insufficient therapy during HIV-1 replication can promote the emergence of drug-resistant strains, reduce the effectiveness of antiretroviral treatment (ART), and increase the likelihood of the onward transmission of drug-resistant viruses. We characterized, for the first time, the prevalence of HIV-1 subtypes and drug resistance mutations in a western region of Iran. METHODS: This study was conducted among 122 patients on ART at a major referral center in Kermanshah, Iran...
August 10, 2017: Intervirology
https://www.readbyqxmd.com/read/28772262/evolution-and-emergence-of-pathogenic-viruses-past-present-and-future
#9
Mohammad K Parvez, Shama Parveen
Incidences of emerging/re-emerging deadly viral infections have significantly affected human health despite extraordinary progress in the area of biomedical knowledge. The best examples are the recurring outbreaks of dengue and chikungunya fever in tropical and sub-tropical regions, the recent epidemic of Zika in the Americas and the Caribbean, and the SARS, MERS, and influenza A outbreaks across the globe. The established natural reservoirs of human viruses are mainly farm animals, and, to a lesser extent, wild animals and arthropods...
August 4, 2017: Intervirology
https://www.readbyqxmd.com/read/28772259/high-frequency-of-human-leukocyte-antigen-b-57-01-allele-carriers-among-hiv-infected-patients-in-serbia
#10
Marina Siljic, Dubravka Salemovic, Valentina Cirkovic, Ivana Pesic-Pavlovic, Marija Todorovic, Jovan Ranin, Gordana Dragovic, Djordje Jevtovic, Maja Stanojevic
Abacavir is an effective antiretroviral drug and one of the most commonly used nucleoside reverse transcriptase inhibitors in Serbia. А percentage of the treated patients experience a potentially life-threatening hypersensitivity reaction, which was shown to be associated with the presence of the class I MHC allele, HLA-B*57:01; hence genotyping for HLA-B*57:01 prior to starting abacavir is nowadays recommended in international HIV treatment guidelines. In Serbia, this testing became available in 2013. This study was designed to estimate the prevalence of the HLA-B*57:01 allele in Serbian HIV-1-infected patients...
August 4, 2017: Intervirology
https://www.readbyqxmd.com/read/28723690/distribution-of-human-papillomavirus-genotypes-among-women-in-mashhad-iran
#11
Eskandar Taghizadeh, Forough Taheri, Hamed Abdolkarimi, Pedram Ghorbani Renani, Seyed Mohammad Gheibi Hayat
OBJECTIVE: Cervical cancer is the third most common malignancy in females. Since the human papillomavirus (HPV) genotype can vary geographically, it is essential to define its genotypic distribution before establishing health care policies and vaccination programs in any given area. The aim of this study was to determine the frequency of HPV types in women in Mashhad, Iran. METHODS: We used nested PCR and reverse dot-blot hybridization for genotyping. The study included 143 cervical cytology samples from Mashhad with confirmed papillomavirus infection by molecular methods...
July 20, 2017: Intervirology
https://www.readbyqxmd.com/read/28683463/middle-east-respiratory-syndrome-coronavirus-and-pulmonary-tuberculosis-coinfection-implications-for-infection-control
#12
Sarah H Alfaraj, Jaffar A Al-Tawfiq, Talal A Altuwaijri, Ziad A Memish
Coinfection of Middle East respiratory syndrome coronavirus (MERS-CoV) with tuberculosis (TB) has not been previously reported. Here, we present 2 cases with both MERS-CoV and pulmonary TB. The first case was a 13-year-old patient who was admitted with a 2-month history of fever, weight loss, night sweats, and cough. The second patient was a 30-year-old female who had a 4-week history of cough associated with shortness of breath and weight loss of 2 kg. The 2 patients were diagnosed with pulmonary TB and had positive MERS-CoV...
July 6, 2017: Intervirology
https://www.readbyqxmd.com/read/28614823/resistance-of-enteric-viruses-on-fomites
#13
Enagnon Kazali Alidjinou, Famara Sane, Swan Firquet, Pierre-Emmanuel Lobert, Didier Hober
Human enteric viruses are associated with several clinical features, especially gastroenteritis. Large amounts of these viruses can be released in the environment and spread to people. Enteric viruses are nonenveloped viruses and have displayed good survival in the environment. They can be significantly resistant in food and water but also on fomites, and this is thought to play a role in transmission, leading to sporadic cases or outbreaks. The survival of enteric viruses on fomites relies on many factors including the virus itself, fomite properties, and extrinsic environmental factors such as temperature or relative humidity...
June 15, 2017: Intervirology
https://www.readbyqxmd.com/read/28675900/hiv-1-subtype-diversity-and-prevalence-of-primary-drug-resistance-in-a-single-center-pediatric-cohort-in-germany
#14
Jennifer Neubert, Nadja Michalsky, Hans-Jürgen Laws, Arndt Borkhardt, Björn Jensen, Nadine Lübke
OBJECTIVES: Data on drug-resistant mutations (DRMs) in HIV-1-infected therapy-naïve children are scarce. The aim of this study was to determine the HIV-1 subtype distribution and the prevalence of DRMs in therapy-naïve HIV-1-infected children who received routine care at the University Hospital Düsseldorf, Düsseldorf, Germany. METHODS: Records of all HIV-1-infected children who received routine care between January 2005 and December 2015 were analyzed retrospectively...
2016: Intervirology
https://www.readbyqxmd.com/read/28668959/contribution-of-next-generation-sequencing-to-aquatic-and-fish-virology
#15
Andriniaina Andy Nkili-Meyong, Laurent Bigarré, Ingrid Labouba, Tatiana Vallaeys, Jean-Christophe Avarre, Nicolas Berthet
The recent technological advances in nucleic acid sequencing, called next-generation sequencing (NGS), have revolutionized the field of genomics and have also influenced viral research. Aquatic viruses, and especially those infecting fish, have also greatly benefited from NGS technologies, which provide a huge amount of molecular information at a low cost in a relatively short period of time. Here, we review the use of the current high-throughput sequencing platforms with a special focus on the associated challenges (regarding sample preparation and bioinformatics) in their applications to the field of aquatic virology, especially for: (i) discovering novel viruses that may be associated with fish mortalities, (ii) elucidating the mechanisms of pathogenesis, and finally (iii) studying the molecular epidemiology of these pathogens...
2016: Intervirology
https://www.readbyqxmd.com/read/28641298/generation-of-a-dna-launched-reporter-replicon-based-on-dengue-virus-type-2-as-a-multipurpose-platform
#16
Jose A Usme-Ciro, Jaime A Lopera, Diego A Alvarez, Luis Enjuanes, Fernando Almazán
Dengue viruses (DENV) have become the most important arthropod-borne viruses, causing dengue and severe dengue fever in at least 50-100 million cases each year, mainly in tropical and subtropical countries. During recent years, important advances in the molecular biology concerning the life cycle of these viruses have allowed the manipulation and generation of recombinant viruses and replicons with multiple applications, mainly in viral biology and the screening of antiviral compounds. In the present study, we describe the construction of an enhanced green fluorescent protein-bearing DENV replicon under the control of the cytomegalovirus immediate early promoter...
2016: Intervirology
https://www.readbyqxmd.com/read/28637040/a-possible-role-of-therapeutic-drug-monitoring-in-virological-breakthrough-during-simeprevir-and-peg-ifn-treatment-in-hcv-4
#17
Lucio Boglione, Tina Ruggiero, Amedeo De Nicolò, Antonio D'Avolio, Giovanni Di Perri
No abstract text is available yet for this article.
2016: Intervirology
https://www.readbyqxmd.com/read/28468008/effect-of-maxing-shigan-tang-on-h1n1-influenza-a-virus-associated-acute-lung-injury-in-mice
#18
Yanchun Zhong, Jie Zhou, Ning Liang, Bihao Liu, Ruirui Lu, Yu He, Chunlin Liang, Junbiao Wu, Yuan Zhou, Miaomiao Hu, Jiuyao Zhou
OBJECTIVE: This study is aimed at examining the effects of Maxing Shigan Tang (MST) treatment on H1N1-associated acute lung injury (ALI) and exploring the possible mechanism. MATERIAL AND METHODS: Mice were randomly divided into a control group, model group, peroxisomal proliferator activator receptor γ (PPARγ) inhibition group (PPARγ-), PPARγ activation group (PPARγ+), and MST group. Influenza A (H1N1) virus of the Fort Monmouth 1 (FM1) strain was used to induce an ALI mice model...
2016: Intervirology
https://www.readbyqxmd.com/read/28402975/frequent-pul27-variations-in-hiv-infected-patients
#19
Azam Mirarab, Alireza Mohebbi, Abdolvahab Moradi, Naeme Javid, Mohammad Ali Vakili, Alijan Tabarraei
OBJECTIVE: Drug-resistant isolates of human cytomegalovirus (HCMV) have led to the development of new anti-HCMV drugs. Maribavir (MBV) is a novel inhibitor of the HCMV viral kinase. Resistance to MBV is mapped to gene UL27, a viral nuclear protein. In this study, we investigated UL27 polymorphisms in MBV-naive HIV-positive and HCMV congenitally infected clinical samples. METHODS: DNA was extracted from 20 CMV-positive HIV (9/20) and congenitally infected (11/20) patients and used for UL27 polymerase chain reaction amplification...
2016: Intervirology
https://www.readbyqxmd.com/read/28402973/low-risk-of-developing-chronic-hepatitis-e-in-heart-transplant-recipients-a-prospective-2-year-follow-up-study
#20
Sven Pischke, Christoph Bara, Patrick Behrendt, Axel Haverich, Michael P Manns, Heiner Wedemeyer
No abstract text is available yet for this article.
2016: Intervirology
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