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Annals of Biomedical Engineering

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https://www.readbyqxmd.com/read/28540448/sensor-based-balance-measures-outperform-modified-balance-error-scoring-system-in-identifying-acute-concussion
#1
Laurie A King, Martina Mancini, Peter C Fino, James Chesnutt, Clayton W Swanson, Sheila Markwardt, Julie C Chapman
Balance assessment is an integral component of concussion evaluation and management. Although the modified balance error scoring system (mBESS) is the conventional clinical tool, objective metrics derived from wearable inertial sensors during the mBESS may increase sensitivity in detecting subtle balance deficits post-concussion. The aim of this study was to identify which stance condition and postural sway metrics obtained from an inertial sensor placed on the lumbar spine during the mBESS best discriminate athletes with acute concussion...
May 24, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28536786/future-prospects-for-human-tissue-engineered-urethra-transplantation-decellularization-and-recellularization-based-urethra-regeneration
#2
Abdol-Mohammad Kajbafzadeh, Reza Abbasioun, Shabnam Sabetkish, Nastaran Sabetkish, Parvin Rahmani, Kamyar Tavakkolitabassi, Hamid Arshadi
To evaluate the histological characteristics of decellularized human urethra after transplantation into the rat omentum and compare in vivo cell seeding with perfusion-based and cell sheet urethral regeneration. Eight adult human male urethras accompanied with the surrounding corpus spongiosum were obtained. The tissues were decellularized with detergent-based method. The efficacy of decellularization and extracellular matrix preservation was evaluated by several techniques. Decellularized scaffolds were transplanted into the omentum of 12 male rats and located into the scrotum...
May 23, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28523516/pre-operative-screening-and-manual-drilling-strategies-to-reduce-the-risk-of-thermal-injury-during-minimally-invasive-cochlear-implantation-surgery
#3
Neal P Dillon, Loris Fichera, Kyle Kesler, M Geraldine Zuniga, Jason E Mitchell, Robert J Webster, Robert F Labadie
This article presents the development and experimental validation of a methodology to reduce the risk of thermal injury to the facial nerve during minimally invasive cochlear implantation surgery. The first step in this methodology is a pre-operative screening process, in which medical imaging is used to identify those patients that present a significant risk of developing high temperatures at the facial nerve during the drilling phase of the procedure. Such a risk is calculated based on the density of the bone along the drilling path and the thermal conductance between the drilling path and the nerve, and provides a criterion to exclude high-risk patients from receiving the minimally invasive procedure...
May 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28512702/an-intracardiac-soft-robotic-device-for-augmentation-of-blood-ejection-from-the-failing-right-ventricle
#4
Markus A Horvath, Isaac Wamala, Eric Rytkin, Elizabeth Doyle, Christopher J Payne, Thomas Thalhofer, Ignacio Berra, Anna Solovyeva, Mossab Saeed, Sara Hendren, Ellen T Roche, Pedro J Del Nido, Conor J Walsh, Nikolay V Vasilyev
We introduce an implantable intracardiac soft robotic right ventricular ejection device (RVED) for dynamic approximation of the right ventricular (RV) free wall and the interventricular septum (IVS) in synchrony with the cardiac cycle to augment blood ejection in right heart failure (RHF). The RVED is designed for safe and effective intracardiac operation and consists of an anchoring system deployed across the IVS, an RV free wall anchor, and a pneumatic artificial muscle linear actuator that spans the RV chamber between the two anchors...
May 16, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28512701/estimation-of-3d-ground-reaction-force-using-nanocomposite-piezo-responsive-foam-sensors-during-walking
#5
Parker G Rosquist, Gavin Collins, A Jake Merrell, Noelle J Tuttle, James B Tracy, Evan T Bird, Matthew K Seeley, David T Fullwood, William F Christensen, Anton E Bowden
This paper describes a method for the estimation of the 3D ground reaction force (GRF) during human walking using novel nanocomposite piezo-responsive foam (NCPF) sensors. Nine subjects (5 male, 4 female) walked on a force-instrumented treadmill at 1.34 m/s for 120 s each while wearing a shoe that was instrumented with four NCPF sensors. GRF data, measured via the treadmill, and sensor data, measured via the NCPF inserts, were used in a tenfold cross validation process to calibrate a separate model for each individual...
May 16, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28497321/predicting-cumulative-and-maximum-brain-strain-measures-from-hybridiii-head-kinematics-a-combined-laboratory-study-and-post-hoc-regression-analysis
#6
Brooklynn M Knowles, Christopher R Dennison
Due to growing concern on brain injury in sport, and the role that helmets could play in preventing brain injury caused by impact, biomechanics researchers and helmet certification organizations are discussing how helmet assessment methods might change to assess helmets based on impact parameters relevant to brain injury. To understand the relationship between kinematic measures and brain strain, we completed hundreds of impacts using a 50th percentile Hybrid III head-neck wearing an ice hockey helmet and input three-dimensional impact kinematics to a finite element brain model called the Simulated Injury Monitor (SIMon) (n = 267)...
May 11, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28488217/electrical-stimulation-increases-random-migration-of-human-dermal-fibroblasts
#7
Sarah Snyder, Carlisle DeJulius, Rebecca Kuntz Willits
Exogenous electrical stimulation (ES) has been investigated as a therapy for chronic wounds, as the skin produces currents and electrical fields (EFs) during wound healing. ES therapies operate by applying small EFs to the skin to mimic the transepithelial potentials that occur during the granulation phase of wound healing. Here, we investigated the effect of short duration (10 min) ES on the migration of HDFs using various magnitudes of physiologically relevant EFs. We modeled cutaneous injury by culturing HDFs in custom chambers that allowed the application of ES and then performed timelapse microscopy on a standard wound model...
May 9, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28488216/knock-out-serum-replacement-and-melatonin-effects-on-germ-cell-differentiation-in-murine-testicular-explant-cultures
#8
Ahmed Reda, Halima Albalushi, Sheyla Cisneros Montalvo, Mirja Nurmio, Zeliha Sahin, Mi Hou, Niels Geijsen, Jorma Toppari, Olle Söder, Jan-Bernd Stukenborg
Finding robust culture conditions for in vitro maturation (IVM) of male germ cells is still a challenge. Recently, a testis organ culture method, using Knockout Serum Replacement (KSR), was suggested as a promising approach. However, the efficiency of that model is still not optimal. Hence, we have tried to establish the culture conditions in two laboratories, and to improve the reliability of the culture system to generate mature germ cells. Male mice at three days of age were sacrificed. Testes were cut into small pieces which were cultured atop agarose stands, using Minimum Essential Medium alpha supplemented with different supplements; melatonin, Glutamax, and different concentrations of KSR...
May 9, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28488215/numerical-simulation-of-stent-angioplasty-with-predilation-an-investigation-into-lesion-constitutive-representation-and-calcification-influence
#9
C Conway, J P McGarry, E R Edelman, P E McHugh
It is acceptable clinical practice to predilate a severely occluded vessel to allow better positioning of endovascular stents, and while the impact of this intervention has been examined for aggregate response in animals there has been no means to examine whether there are specific vessels that might benefit. Finite element methods offer the singular ability to explore the mechanical response of arteries with specific pathologic alterations in mechanics to stenting and predilation. We examined varying representations of atherosclerotic tissue including homogeneous and heterogeneous dispersion of calcified particles, and elastic, pseudo-elastic, and elastic-plastic constitutive representations of bulk atherosclerotic tissue...
May 9, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28484892/subject-specific-optimisation-of-the-stiffness-of-footwear-material-for-maximum-plantar-pressure-reduction
#10
Panagiotis E Chatzistergos, Roozbeh Naemi, Aoife Healy, Peter Gerth, Nachiappan Chockalingam
Current selection of cushioning materials for therapeutic footwear and orthoses is based on empirical and anecdotal evidence. The aim of this investigation is to assess the biomechanical properties of carefully selected cushioning materials and to establish the basis for patient-specific material optimisation. For this purpose, bespoke cushioning materials with qualitatively similar mechanical behaviour but different stiffness were produced. Healthy volunteers were asked to stand and walk on materials with varying stiffness and their capacity for pressure reduction was assessed...
May 9, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28477057/real-time-prediction-of-temperature-elevation-during-robotic-bone-drilling-using-the-torque-signal
#11
Arne Feldmann, Kate Gavaghan, Manuel Stebinger, Tom Williamson, Stefan Weber, Philippe Zysset
Bone drilling is a surgical procedure commonly required in many surgical fields, particularly orthopedics, dentistry and head and neck surgeries. While the long-term effects of thermal bone necrosis are unknown, the thermal damage to nerves in spinal or otolaryngological surgeries might lead to partial paralysis. Previous models to predict the temperature elevation have been suggested, but were not validated or have the disadvantages of computation time and complexity which does not allow real time predictions...
May 5, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28474271/can-recovery-foot-placement-affect-older-adults-slip-fall-severity
#12
Shuaijie Wang, Xuan Liu, Anna Lee, Yi-Chung Pai
Following a slip occurred in the overground walking, a fall can be classified into two exclusive categories: feet-forward fall or split fall. The purposes of this study were to investigate whether the placement of the recovery foot would determine the slip types, the likelihood of fall, and the severity associated with each fall. The fall severity was estimated based on the impact velocity of body segments or trunk orientation upon fall arrest. One hundred ninety-five participants experienced a novel, unannounced slip while walking on a 7-m walkway...
May 4, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28474270/stenosis-hemodynamics-disrupt-the-endothelial-cell-glycocalyx-by-mmp-activity-creating-a-proinflammatory-environment
#13
S Cooper, K McDonald, D Burkat, Richard L Leask
Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to different stimuli and hypothesized as an important contributor to the mechanotransduction of wall shear stresses (WSS). In this work, we used a three dimensional in vitro EC culture model with a 50% asymmetric stenosis to investigate degradation of the GCX by increased matrix metalloproteinase (MMP) activity in regions of WSS gradients and how this degradation might create a proinflammatory environment...
May 4, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28470459/a-finite-element-model-of-the-foot-ankle-to-evaluate-injury-risk-in-various-postures
#14
Chris Smolen, Cheryl E Quenneville
The foot/ankle complex is frequently injured in many types of debilitating events, such as car crashes. Numerical models used to assess injury risk are typically minimally validated and do not account for ankle posture variations that frequently occur during these events. The purpose of this study was to evaluate a finite element model of the foot and ankle accounting for these positional changes. A model was constructed from computed tomography scans of a male cadaveric lower leg and was evaluated by comparing simulated bone positions and strain responses to experimental results at five postures in which fractures are commonly reported...
May 3, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28462479/age-has-a-minimal-effect-on-the-impact-performance-of-field-used-bicycle-helmets
#15
Alyssa L DeMarco, Craig A Good, Dennis D Chimich, Jeff A Bakal, Gunter P Siegmund
Helmet manufacturers recommend replacing a bicycle helmet after an impact or after anywhere from 2 to 10 years of use. The goal of this study was to quantify the effect of helmet age on peak headform acceleration during impact attenuation testing of field-used bicycle helmets. Helmets were acquired by donation from consumers and retail stores, and were included in the study if they were free of impact-related damage, had a legible manufacture date label, and were certified to at least one helmet standard. Helmets (n = 770) spanning 0-26 years old were drop tested to measure peak linear headform acceleration during impacts to the right and left front regions of the helmets at two impact speeds (3...
May 1, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28455786/individual-impact-magnitude-vs-cumulative-magnitude-for-estimating-concussion-odds
#16
Kathryn L O'Connor, Thomas Peeters, Stefan Szymanski, Steven P Broglio
Helmeted impact devices have allowed researchers to investigate the biomechanics of head impacts in vivo. While increased impact magnitude has been associated with greater concussion risk, a definitive concussive threshold has not been established. It is likely that concussion risk is not determined by a single impact itself, but a host of predisposing factors. These factors may include genetics, fatigue, and/or prior head impact exposure. The objective of the current paper is to investigate the association between cumulative head impact magnitude and concussion risk...
April 28, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28451990/chest-wall-kinematics-using-triangular-cosserat-point-elements-in-healthy-and-neuromuscular-subjects
#17
Dana Solav, Henri Meric, M B Rubin, Didier Pradon, Frédéric Lofaso, Alon Wolf
Optoelectronic plethysmography (OEP) is a noninvasive method for assessing lung volume variations and the contributions of different anatomical compartments of the chest wall (CW) through measurements of the motion of markers attached to the CW surface. The present study proposes a new method for analyzing the local CW kinematics from OEP measurements based on the kinematics of triangular Cosserat point elements (TCPEs). 52 reflective markers were placed on the anterior CW to create a mesh of 78 triangles according to an anatomical model...
April 27, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28451989/tissue-engineered-human-amniotic-membrane-application-in-mouse-ovarian-follicular-culture
#18
M Motamed, Z Sadr, M R Valojerdi, A Moini, S Oryan, M Totonchi, B Ebrahimi, S Maroufizadeh, E Taghiabadi, R Fathi
Since folliculogenesis requires a powerful cell-matrix interaction, natural scaffolds seem to be needed for follicular culture. Human amniotic membrane (HAM) offers promise as a support of in vitro ovarian follicular culture. HAM was decellularized with trypsin and EDTA. DNA and histology assays were performed to determine the elimination rate of genomic components. Cyto-biocompatibility of decellular AM (DAM) was verified by the cell viability (MTT) test. The small parts of intact amniotic membrane (IAM) and DAM were coated on the bottom of 96-well and each well was filled with 150 µL of base medium...
April 27, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28447179/influence-of-inherent-mechanophenotype-on-competitive-cellular-adherence
#19
Manisha K Shah, Iris H Garcia-Pak, Eric M Darling
Understanding the role of mechanophenotype in competitive adherence of cells to other cells versus underlying substrates can inform such processes as tissue development, cancer progression, and wound healing. This study investigated how mechanophenotype, defined by whole-cell, elastic/viscoelastic properties for the perinuclear region, and cellular assembly are intertwined through the mechanosensing process. Atomic force microscopy was used to characterize the temporal elastic/viscoelastic properties of individual and assembled fibroblasts grown on substrates with elastic moduli above, below, or similar to whole-cell mechanophenotypes measured for three, genetically modified cell lines...
April 26, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28447178/an-mri-guided-telesurgery-system-using-a-fabry-perot-interferometry-force-sensor-and-a-pneumatic-haptic-device
#20
Hao Su, Weijian Shang, Gang Li, Niravkumar Patel, Gregory S Fischer
This paper presents a surgical master-slave teleoperation system for percutaneous interventional procedures under continuous magnetic resonance imaging (MRI) guidance. The slave robot consists of a piezoelectrically actuated 6-degree-of-freedom (DOF) robot for needle placement with an integrated fiber optic force sensor (1-DOF axial force measurement) using the Fabry-Perot interferometry (FPI) sensing principle; it is configured to operate inside the bore of the MRI scanner during imaging. By leveraging the advantages of pneumatic and piezoelectric actuation in force and position control respectively, we have designed a pneumatically actuated master robot (haptic device) with strain gauge based force sensing that is configured to operate the slave from within the scanner room during imaging...
April 26, 2017: Annals of Biomedical Engineering
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