journal
MENU ▼
Read by QxMD icon Read
search

Toxicology

journal
https://www.readbyqxmd.com/read/28928034/letter-to-the-editor
#1
LETTER
Guillemette Crépeaux, Christopher Exley, Christopher A Shaw, Romain K Gherardi
No abstract text is available yet for this article.
September 16, 2017: Toxicology
https://www.readbyqxmd.com/read/28928033/linking-the-generation-of-dna-adducts-to-lung-cancer
#2
Marcello Ceppi, Armelle Munnia, Filippo Cellai, Marco Bruzzone, Marco E M Peluso
Worldwide, lung cancer is the leading cause of cancer death. DNA adducts are considered a reliable biomarker that reflects carcinogen exposure to tobacco smoke, but the central question is what is the relationship of DNA adducts and cancer? Therefore, we investigated this relationship by a meta-analysis of twenty-two studies with bronchial adducts for a total of 1,091 subjects, 887 lung cancer cases and 204 apparently healthy individuals with no evidence of lung cancer. Our study shows that these adducts are significantly associated to increase lung cancer risk...
September 16, 2017: Toxicology
https://www.readbyqxmd.com/read/28917655/inactivation-of-tnf-lt-locus-alters-mouse-metabolic-response-to-concentrated-ambient-pm2-5
#3
Ziying Hu, Minjie Chen, Huifen Zhou, Anui Tharakan, Xiaoke Wang, Lianglin Qiu, Shuai Liang, Xiaobo Qin, Yuhao Zhang, Wanjun Wang, Yanyi Xu, Zhekang Ying
BACKGROUND: Exposure to ambient fine particulate matter (PM2.5) is associated with increased cardiometabolic morbidity and mortality. This is widely believed to be attributable to PM2.5 exposure-induced pulmonary and subsequent systemic inflammation. Tumor necrosis factor alpha (TNFα), lymphotoxin α (LTα), and lymphotoxin β (LTβ) are three homologous pro-inflammatory cytokines, each with both unique and redundant activities in inflammation. Their role in PM2.5 exposure-induced inflammation and adverse cardiometabolic effects has to be determined...
September 13, 2017: Toxicology
https://www.readbyqxmd.com/read/28916328/primary-hippocampal-neuronal-cell-death-induction-after-acute-and-repeated-paraquat-exposures-mediated-by-ache-variants-alteration-and-cholinergic-and-glutamatergic-transmission-disruption
#4
Javier Del Pino, Paula Moyano, Gloria Gómez Díaz, María José Anadon, Maria Jesus Diaz, José Manuel García, Margarita Lobo, Adela Pelayo, Emma Sola, María Teresa Frejo
Paraquat (PQ) is a widely used non-selective contact herbicide shown to produce memory and learning deficits after acute and repeated exposure similar to those induced in Alzheimer's disease (AD). However, the complete mechanisms through which it induces these effects are unknown. On the other hand, cholinergic and glutamatergic systems, mainly in the hippocampus, are involved on learning, memory and cell viability regulation. An alteration of hippocampal cholinergic or glutamatergic transmissions or neuronal cell loss may induce these effects...
September 12, 2017: Toxicology
https://www.readbyqxmd.com/read/28916327/glycogen-metabolism-in-brain-and-neurons-astrocytes-metabolic-cooperation-can-be-altered-by-pre-and-neonatal-lead-pb-exposure
#5
Irena Baranowska-Bosiacka, Anna Falkowska, Izabela Gutowska, Magdalena Gąssowska, Agnieszka Kolasa-Wołosiuk, Maciej Tarnowski, Karina Chibowska, Marta Goschorska, Dariusz Chlubek
Lead (Pb) is an environmental neurotoxin which particularly affects the developing brain but the molecular mechanism of its neurotoxicity still needs clarification. The aim of this paper was to examine whether pre- and neonatal exposure to Pb (concentration of Pb in rat offspring blood below the "threshold level") may affect the brain's energy metabolism in neurons and astrocytes via the amount of available glycogen. We investigated the glycogen concentration in the brain, as well as the expression of the key enzymes involved in glycogen metabolism in brain: glycogen synthase 1 (Gys1), glycogen phosphorylase (PYGM, an isoform active in astrocytes; and PYGB, an isoform active in neurons) and phosphorylase kinase β (PHKB)...
September 12, 2017: Toxicology
https://www.readbyqxmd.com/read/28899748/biomonitoring-of-2-4-6-trinitrotoluene-and-degradation-products-in-the-marine-environment-with-transplanted-blue-mussels-m-edulis
#6
Jennifer S Strehse, Daniel Appel, Catharina Geist, Hans-Jörg Martin, Edmund Maser
Since World War I considerable amounts of warfare material have been dumped at sea worldwide, but little is known about the fate of the explosive components in the marine environment. Sea dumped munitions are able to contaminate the surroundings because of the release of explosive chemicals due to corrosion and breaching or by detonation after blast-operations. This implies the risk of accumulation of toxic compounds in human and wildlife food chains. With the help of divers, we performed an active biomonitoring study with transplanted blue mussels (M...
September 9, 2017: Toxicology
https://www.readbyqxmd.com/read/28890136/identification-of-lipidomic-markers-of-chronic-3-3-4-4-5-pentachlorobiphenyl-pcb-126-exposure-in-the-male-rat-liver
#7
Izabela Kania-Korwel, Xianai Wu, Kai Wang, Hans-Joachim Lehmler
Exposure to PCB 126, an environmentally relevant aryl hydrocarbon receptor agonist, is an environmental factor causing hepatic steatosis in rodent models; however, the lipidome of PCB 126-exposed rats has not been investigated in-depth. The objective of the present study was therefore to characterize dose-dependent changes in the lipid profile in the liver of male Sprague-Dawley rats exposed to PCB 126. Rats were exposed for three month to intraperitoneal injections of 0.01, 0.05 and 0.2μmol/kg bw PCB 126 in corn oil...
September 7, 2017: Toxicology
https://www.readbyqxmd.com/read/28888848/prevention-of-oxytosis-induced-c-raf-down-regulation-by-arylthio-cyclopentenone-prostaglandins-is-neuroprotective
#8
Shoko Shibata, Kyoji Furuta, Kentaro Oh-Hashi, Hiroshi Ueda, Kazutoshi Kiuchi, Yoko Hirata
Prolonged exposure to high concentrations of glutamate leads to cell type specific glutathione depletion and resulting oxidative stress, known as oxytosis. As a result of glutathione depletion, accumulation of reactive oxygen species and Ca(2+) influx are increased; however, the specific target of oxytosis has yet to be identified. In the present study, we focused on the effect of glutamate-induced oxidative stress on the extracellular-regulated protein kinase (ERK) pathway using the murine hippocampal HT22 cell line...
September 6, 2017: Toxicology
https://www.readbyqxmd.com/read/28882574/kupffer-cells-activation-promoted-binge-drinking-induced-fatty-liver-by-activating-lipolysis-in-white-adipose-tissues
#9
Yu-Ying Zhao, Rui Yang, Mo Xiao, Min-Jie Guan, Ning Zhao, Tao Zeng
Kupffer cells (KCs) have been suggested to play critical roles in chronic ethanol induced early liver injury, but the role of KCs in binge drinking-induced hepatic steatosis remains unclear. This study was designed to investigate the roles of KCs inhibitor (GdCl3) and TNF-α antagonist (etanercept) on binge drinking-induced liver steatosis and to explore the underlying mechanisms. C57BL/6 mice were exposed to three doses of ethanol (6g/kg body weight) to mimic binge drinking-induced fatty liver. The results showed that both GdCl3 and etanercept partially but significantly alleviated binge drinking-induced increase of hepatic triglyceride (TG) level, and reduced fat droplets accumulation in mice liver...
September 4, 2017: Toxicology
https://www.readbyqxmd.com/read/28882573/scientific-and-ethical-obligations-to-publish-tobacco-industry-funded-research-on-nicotine-delivery-systems-of-reduced-risk
#10
LETTER
Riccardo Polosa, Francis P Crawley
No abstract text is available yet for this article.
September 4, 2017: Toxicology
https://www.readbyqxmd.com/read/28882572/identification-of-essential-transcription-factors-for-adequate-dna-damage-response-after-benzo-a-pyrene-and-aflatoxin-b1-exposure-by-combining-transcriptomics-with-functional-genomics
#11
Evelyn Smit, Terezinha Souza, Danyel G J Jennen, Jos C S Kleinjans, Twan van den Beucken
DNA damage mediates widespread changes in transcription through activation or repression of transcription factors (TFs). However, the consequences of regulating specific TFs for the outcome of the DNA repair process remain incompletely understood. Here, we combined transcriptomics and TF binding prediction with functional genomics to identify TFs essential for adequate DNA repair in HepG2 liver cells after a non-cytotoxic dose of carcinogens benzo(a)pyrene (BaP) (2μM) and aflatoxin B1 (AFB1) (5μM). BaP and AFB1 induced a largely common transcriptional response, mediated by similar TFs...
September 4, 2017: Toxicology
https://www.readbyqxmd.com/read/28865727/altered-mitochondrial-epigenetics-associated-with-subchronic-doxorubicin-cardiotoxicity
#12
André Ferreira, Teresa Cunha-Oliveira, Rui F Simões, Filipa S Carvalho, Ana Burgeiro, Kendra Nordgren, Kendall B Wallace, Paulo J Oliveira
Doxorubicin (DOX), a potent and broad-spectrum antineoplastic agent, causes an irreversible, cumulative and dose-dependent cardiomyopathy that ultimately leads to congestive heart failure. The mechanisms responsible for DOX cardiotoxicity remain poorly understood, but seem to involve mitochondrial dysfunction on several levels. Epigenetics may explain a portion of this effect. Since mitochondrial dysfunction may affect the epigenetic landscape, we hypothesize that this cardiac toxicity may result from epigenetic changes related to disruption of mitochondrial function...
September 1, 2017: Toxicology
https://www.readbyqxmd.com/read/28865728/gender-specific-association-of-exposure-to-non-dioxin-like-polychlorinated-biphenyls-during-pregnancy-with-methylation-levels-of-h19-and-long-interspersed-nuclear-element-1-in-cord-blood-in-the-hokkaido-study
#13
Sumitaka Kobayashi, Fumihiro Sata, Chihiro Miyashita, Ryu Miura, Kaoru Azumi, Sachiko Kobayashi, Houman Goudarzi, Atsuko Araki, Mayumi Ishizuka, Takashi Todaka, Jumboku Kajiwara, Tsuguhide Hori, Reiko Kishi
BACKGROUND: Associations between prenatal exposure to polychlorinated biphenyls (PCBs) and reduced birth-size, and between DNA methylation of insulin-like growth factor-2 (IGF-2), H19 locus, and long interspersed nuclear element-1 (LINE-1) and reduced birth-size are well established. To date, however, studies on the associations between prenatal exposure to PCBs and alterations in methylation of IGF-2, H19, and LINE-1 are lacking. Thus, in this study, we examined these associations with infant-gender stratification...
August 30, 2017: Toxicology
https://www.readbyqxmd.com/read/28855114/mitochondrial-epigenetic-crosstalk-in-environmental-toxicology
#14
Caren Weinhouse
Crosstalk between the nuclear epigenome and mitochondria, both in normal physiological function and in responses to environmental toxicant exposures, is a developing sub-field of interest in environmental and molecular toxicology. The majority (∼99%) of mitochondrial proteins are encoded in the nuclear genome, so programmed communication among nuclear, cytoplasmic, and mitochondrial compartments is essential for maintaining cellular health. In this review, we will focus on correlative and mechanistic evidence for direct impacts of each system on the other, discuss demonstrated or potential crosstalk in the context of chemical insult, and highlight biological research questions for future study...
August 27, 2017: Toxicology
https://www.readbyqxmd.com/read/28851516/brominated-and-organophosphate-flame-retardants-target-different-neurodevelopmental-stages-characterized-with-embryonic-neural-stem-cells-and-neuronotypic-pc12-cells
#15
Theodore A Slotkin, Samantha Skavicus, Heather M Stapleton, Frederic J Seidler
In addition to their activity as endocrine disruptors, brominated and organophosphate flame retardants are suspected to be developmental neurotoxicants, although identifying their specific mechanisms for that activity has been elusive. In the current study, we evaluated the effects of several flame retardants on neurodifferentiation using two in vitro models that assess distinct "decision nodes" in neural cell development: embryonic rat neural stem cells (NSCs), which evaluate the origination of neurons and glia from precursors, and rat neuronotypic PC12 cells, which characterize a later stage where cells committed to a neuronal phenotype undergo neurite outgrowth and neurotransmitter specification...
August 26, 2017: Toxicology
https://www.readbyqxmd.com/read/28842382/varenicline-promotes-endothelial-cell-migration-by-lowering-vascular-endothelial-cadherin-levels-via-the-activated-%C3%AE-7-nicotinic-acetylcholine-receptor-mitogen-activated-protein-kinase-axis
#16
Mitsuhisa Koga, Yuki Kanaoka, Keita Sugiyama, Kaoru Ohishi, Yuka Ejima, Mami Hisanaga, Yasufumi Kataoka, Atsushi Yamauchi
Varenicline is a widely used and effective drug for smoking cessation. Despite its efficacy, varenicline increases the risk of cardiovascular disease. We previously demonstrated that varenicline aggravates atherosclerotic plaque formation in apolipoprotein E knockout mice. However, little is known about its effects in vascular endothelial cells. Therefore, we examined whether varenicline promotes migration of human umbilical vein endothelial cells (HUVECs) using the Boyden chamber assay. Varenicline (100μM) markedly promoted migration of HUVECs and decreased expression of vascular endothelial (VE)-cadherin, an endothelial adhesion molecule...
August 24, 2017: Toxicology
https://www.readbyqxmd.com/read/28842383/glucagon-like-peptide-2-prevents-down-regulation-of-intestinal-multidrug-resistance-associated-protein-2-and-p-glycoprotein-in-endotoxemic-rats
#17
Maite Rocío Arana, Guillermo Nicolás Tocchetti, Felipe Zecchinati, Ana Sofía Londero, Camila Dominguez, Virginia Perdomo, Juan Pablo Rigalli, Silvina Stella Maris Villanueva, Aldo Domingo Mottino
Multidrug resistance-associated protein 2 (Mrp2, ABCC2) and P-glycoprotein (P-gp, ABCB1) constitute essential components of the intestinal biochemical barrier that prevent incorporation of food contaminants, drugs or toxic metabolites into the blood stream. Endotoxemia induced in rats by administration of bacterial lipopolysaccharide (LPS) results in elevated intestinal permeability and toxicity of xenobiotics in part associated with down-regulation of expression and activity of Mrp2 and P-gp. We evaluated the protective effect of glucagon-like peptide 2 (GLP-2), a peptide hormone with enterotrophic properties, on Mrp2 and P-gp alterations induced by single i...
August 23, 2017: Toxicology
https://www.readbyqxmd.com/read/28838641/mitochondrial-toxicity-of-tobacco-smoke-and-air-pollution
#18
Jessica L Fetterman, Melissa J Sammy, Scott W Ballinger
No abstract text is available yet for this article.
August 22, 2017: Toxicology
https://www.readbyqxmd.com/read/28826906/aluminum-exposure-at-human-dietary-levels-promotes-vascular-dysfunction-and-increases-blood-pressure-in-rats-a-concerted-action-of-nad-p-h-oxidase-and-cox-2
#19
Caroline Silveira Martinez, Janaina Trindade Piagette, Alyne Gourlart Escobar, Ángela Martín, Roberto Palacios, Franck Maciel Peçanha, Dalton Valentim Vassallo, Christopher Exley, María Jesús Alonso, Marta Miguel, Mercedes Salaices, Giulia Alessandra Wiggers
Aluminum (Al) is a non-essential metal and a significant environmental contaminant and is associated with a number of human diseases including cardiovascular disease. We investigated the effects of Al exposure at doses similar to human dietary levels on the cardiovascular system over a 60day period. Wistar male rats were divided into two major groups and received orally: 1) Low aluminum level - rats were subdivided and treated for 60days as follows: a) Untreated - ultrapure water; b) AlCl3 at a dose of 8.3mg/kg bw for 60days, representing human Al exposure by diet; and 2) High aluminum level - rats were subdivided and treated for 42days as follows: C) Untreated - ultrapure water; d) AlCl3 at 100mg/kg bw for 42days, representing a high level of human exposure to Al...
August 19, 2017: Toxicology
https://www.readbyqxmd.com/read/28823913/dysregulation-of-dna-methylation-and-expression-of-imprinted-genes-in-mouse-placentas-of-fetal-growth-restriction-induced-by-maternal-cadmium-exposure
#20
Peng Xu, Zhongqiang Wu, Weiwei Yang, Lan Wang
Cadmium (Cd) is one of the most toxic environmental pollutants that cause fetal malformation and growth restriction. However, the molecular mechanisms underlying maternal Cd toxicity on fetal growth remain largely unknown. Specifically, the expression profiles and the regulation mechanisms of the imprinted genes, have been poorly characterized in the etiology of Cd-induced fetal growth restriction (FGR). In the present study, 13 imprinted genes associated with the fetal growth and placenta development were selected and their expression patterns were examined in the Cd-exposed placentas...
August 17, 2017: Toxicology
journal
journal
23083
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"