Cristian E Cadena-Caballero, Nestor Munive-Argüelles, Lina M Vera-Cala, Carlos Barrios-Hernandez, Ruben O Duarte-Bernal, Viviana L Ayus-Ortiz, Luis A Pardo-Díaz, Mayra Agudelo-Rodríguez, Lola X Bautista-Rozo, Laura R Jimenez-Gutierrez, Francisco Martinez-Perez
In the year 2002, DNA loss model (DNA-LM) postulated that neuropeptide genes to emerged through codons loss via the repair of damaged DNA from ancestral gene namely Neuropeptide Precursor Predictive (NPP), which organization correspond two or more neuropeptides precursors evolutive related. The DNA-LM was elaborated according to amino acids homology among LWamide, APGWamide, red pigment-concentrating hormone (RPCH), adipokinetic hormones (AKHs) and in silico APGW/RPCH NPPAPGW/AKH NPP were proposed. With the above principle, it was proposed the evolution of corazonin (CRZ), gonadotropin-releasing hormone (GnRH), AKH, and AKH/CRZ (ACP), but any NPP never was considered...
December 16, 2023: Journal of Molecular Evolution