Alessandro Alunni, Constance Pierre, Jorge Torres-Paz, Natacha Clairet, Auriane Langlumé, Marie Pavie, Thomas Escoffier-Pirouelle, Michael Leblanc, Maryline Blin, Sylvie Rétaux
Monoaminergic systems are conserved in vertebrates, yet they present variations in neuroanatomy, genetic components and functions across species. MonoAmine Oxidase, or MAO, is the enzyme responsible for monoamine degradation. While mammals possess two genes, MAO-A and MAO-B, fish possess one single mao gene. To study the function of MAO and monoamine homeostasis on fish brain development and physiology, here we have generated a mao knockout line in Astyanax mexicanus (surface fish), by CRISPR/Cas9 technology...
October 16, 2023: Development, Growth & Differentiation