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Current Medical Research and Opinion

Kenneth T Moore, Peggy Wong, Liping Zhang, Guohua Pan, JoAnne Foody
OBJECTIVE: Atrial fibrillation, peripheral and coronary artery disease and venous thromboembolism are major risk factors for stroke, disability, and death in the rapidly growing older (≥ 65 years.) population. In the absence of clear guidelines on the appropriate use of the newer non-vitamin K antagonist oral anticoagulants in this population, we specifically review the available literature for rivaroxaban and the impact of age that may affect the pharmacokinetics, pharmacodynamics, efficacy and safety of this anticoagulant...
June 22, 2018: Current Medical Research and Opinion
Nina Jendrike, Annette Baumstark, Stefan Pleus, Christina Liebing, Ulrike Kamecke, Cornelia Haug, Guido Freckmann
OBJECTIVE: In this study, accuracy in the hands of intended users was evaluated for five self-monitoring of blood glucose (SMBG) systems based on ISO 15197:2013, and possibly related insulin dosing errors were calculated. In addition, accuracy was assessed in the hands of study personnel Methods: For each system (Accu-Chek® Aviva Connect (A), Contour® Next One (B), FreeStyle Freedom Lite (C), GlucoMen® areo (D), OneTouch® Verio® (E)) one test strip lot was evaluated as required by ISO 15197:2013, clause 8...
June 21, 2018: Current Medical Research and Opinion
Giorgia De Berardis, Marco Scardapane, Giuseppe Lucisano, Santina Abbruzzese, Antonio Carlo Bossi, Elisa Cipponeri, Paola D'Angelo, Lucia Fontana, Roberta Lancione, Giuseppe Marelli, Luigi Sciangula, Antonio Nicolucci
OBJECTIVE: Insulin injection aspects, such as fear of injection and pain, directly affect glycemic control, patient adherence, and quality of life. Use of thinner and shorter needles could increase acceptance of injections. Aim of the study is to evaluate the non-inferiority of the new 34Gx3.5 mm needle compared to a 32GX4mm in patients with diabetes treated with insulin. METHODS: This is an open, randomized, two-period cross-over, noninferiority trial. Every treatment period lasted 3 weeks...
June 20, 2018: Current Medical Research and Opinion
Filipe B Rodrigues, Joaquim J Ferreira, Edward J Wild
No abstract text is available yet for this article.
June 19, 2018: Current Medical Research and Opinion
Sylvi Irawati, Riswandy Wasir, Amand Floriaan Schmidt, Atiqul Islam, Talitha Feenstra, Erik Buskens, Bob Wilffert, Eelko Hak
BACKGROUND: Scientific studies on cardiovascular disease (CVD) burden and risk factors is predominantly based on short-term risk in Westerner populations, and such information may not be applicable to Asian populations, especially over the longer-term. This review aims to estimate the long-term (> 10 years) CVD burden, including coronary heart disease (CHD) and stroke, as well as associated risk factors in Asian populations. METHODS: PubMed®, Embase® , Web of ScienceTM were systematically searched, and hits screened on: Asian adults, free of CVD at baseline; cohort study design (follow-up > 10 years)...
June 19, 2018: Current Medical Research and Opinion
Vítězslav Kolek, Stanislav Losse, Juraj Kultan, Petr Jakubec, Jaromir Zatloukal, Milan Sova, Marek Szkorupa, Čestmír Neoral, Josef Škarda, Tomáš Tichý, Zdeněk Kolář
OBJECTIVES: Adjuvant chemotherapy (AC) in non-small cell lung cancer (NSCLC) has become a standard of care in patients with stages IIA, IIB, and IIIA after complete tumor resection. Utilization and outcome of AC in routine practice is described in a few studies with non-conclusive results. MATERIAL AND METHODS: This retrospective study included consecutive patients with NSCLC who underwent curative-intent surgery. Data of AC uptake in stage IB (tumor of ≥4 cm in diameter), II and IIIA and reasons of AC omission were evaluated according to medical records...
June 18, 2018: Current Medical Research and Opinion
Giulia-Anna Perri, Pamela Liao
No abstract text is available yet for this article.
June 18, 2018: Current Medical Research and Opinion
Muhammad Aziz, Rawish Fatima, Lindsey N Douglass, Omar Abughanimeh, Shahzad Raza
Clostridium difficile infection (CDI) is a significant health burden now recognized as the leading cause of acquired diarrhea in patients receiving antibiotic therapy. Complications of infection with this pathogen include severe diarrhea causing electrolyte imbalances, dehydration, hemodynamic instability, toxic megacolon, shock and death, hence it is extremely paramount to stay updated on management options for this infection especially in cancer patients. This article presents an in-depth review of literature on the treatment modalities available for CDI in cancer patients...
June 11, 2018: Current Medical Research and Opinion
Allison Keshishian, Steven A Greenberg, Neetu Agashivala, Onur Baser, Kristen Johnson
OBJECTIVE: This study identifies the health care costs and utilization, as well as comorbidities, in a Medicare population of inclusion body myositis (IBM) patients. METHODS: Medicare patients aged ≥65 years with a diagnosis claim for IBM were identified and matched to a cohort of non-IBM patients based on age, sex, race, calendar year, and census region. Generalized linear models were used to estimate health care costs and utilization during the follow-up period...
June 7, 2018: Current Medical Research and Opinion
Zsolt Hepp, Kathleen Wyne, Shivaji R Manthena, Siting Wang, Ved Gossain
OBJECTIVE: The objective of this analysis is to compare adherence at 6 months and 12 months across levothyroxine formulations for patients with hypothyroidism. METHODS: This retrospective analysis utilized insurance claims data from a commercially insured population from January 1, 2000 through March 31, 2016. Patients were included if they were diagnosed with hypothyroidism and initiated treatment with generic levothyroxine, Levoxyl®, Synthroid® , Unithroid® or Tirosint® ...
June 7, 2018: Current Medical Research and Opinion
Elise Chia-Hui Tan, Ming-Chin Yang, Chien-Chih Chen
OBJECTIVE: Laparoscopy is a safe and effective treatment for colon cancer. However, its effects on short- and long-term health outcomes and medical utilization are not fully elucidated. The study aimed to compare short- and long-term utilization and health outcomes of colon cancer patients who underwent either laparoscopic or open surgery in a population-based cohort. METHODS: This study was conducted by linking data from Taiwan Cancer Registry, National Health Insurance claims, and Death Registry...
June 4, 2018: Current Medical Research and Opinion
Abdul Jabbar, Wan Mohd Izani Bin Wan Mohamed, Risa Ozaki, Robert Mirasol, Tamas Treuer, Thomas Lew, Rong Qi, Wayne H-H Sheu, Chaicharn Deerochanawong, Steven M Babineaux
OBJECTIVE: Current and future estimates of the burden of diabetes for the Western Pacific (WP) region are among the highest in the world. Verifying Insulin Strategy and Initial Health Outcome Analysis (VISION) was an 18-month observational study that explored treatment approaches in patients with type 2 diabetes mellitus (T2DM) initiating insulin in the WP region. METHODS: A total of 1,065 patients aged ≥18 years with T2DM initiating insulin therapy in normal clinical course were enrolled from Hong Kong, Malaysia, Philippines, Taiwan, and Thailand...
June 4, 2018: Current Medical Research and Opinion
Wendy Y Cheng, Qayyim Said, Yanni Hao, Yongling Xiao, Francis Vekeman, Priyanka Bobbili, Mei Sheng Duh, Savita Nandal, Morey Blinder
OBJECTIVE: To compare real-world adherence to and persistence with deferasirox film-coated tablets (DFX-FCT) and deferasirox dispersible tablets (DFX-DT) among patients who switched from DFX-DT to DFX-FCT, overall and by disease type (sickle cell disease [SCD], thalassemia, and myelodysplastic syndrome [MDS]). METHODS: Patients were ≥2 years old and had ≥2 DFX-FCT claims over the study period and ≥2 DFX-DT claims before the index date (first DFX-FCT claim)...
June 4, 2018: Current Medical Research and Opinion
Abdalla Ibrahim, Tom Kiernan
No abstract text is available yet for this article.
May 30, 2018: Current Medical Research and Opinion
Cristina Stasi, Caterina Silvestri, Roberto Berni, Maurizia Rossana Brunetto, Anna Linda Zignego, Cristina Orsini, Stefano Milani, Liana Ricciardi, Andrea De Luca, Pierluigi Blanc, Cesira Nencioni, Donatella Aquilini, Alessandro Bartoloni, Giampaolo Bresci, Santino Marchi, Franco Filipponi, Piero Colombatto, Paolo Forte, Andrea Galli, Sauro Luchi, Silvia Chigiotti, Alessandro Nerli, Giampaolo Corti, Rodolfo Sacco, Paola Carrai, Angelo Ricchiuti, Massimo Giusti, Paolo Almi, Andrea Cozzi, Silvia Carloppi, Giacomo Laffi, Fabio Voller, Francesco Cipriani
BACKGROUND: Recent introduction of direct antiviral agents (DAAs) has completely changed the scenario regarding HCV treatment. Certain countries' economic health programs prioritise DAAs according to specific clinical features of HCV-infected patients. The aim of this study was to define epidemiological, demographic and clinical characteristics of HCV-infected patients in the Tuscany region of central Italy. METHODS: We enrolled HCV patients with chronic viral hepatitis who were referred to outpatient services of 15 hospitals in Tuscany from January 1, 2015, to December 31, 2015...
May 30, 2018: Current Medical Research and Opinion
Anthony Dragovich, Fred Brason, Thomas Beltran, Amy McCoart, Anthony R Plunkett
OBJECTIVES: The purpose of this study was to determine if employing a home healthcare model for education and treatment of opioid overdose using the Evzio (Naloxone) auto-injector in a private practice pain clinic. METHODS: A prospective survey was used to determine the feasibility of integrating a naloxone auto-injector within the patient's home with a home care training model. Twenty moderate or high-risk patients were enrolled from the chronic pain clinic. Patients who were moderate or high risk completed an evaluation survey...
May 30, 2018: Current Medical Research and Opinion
Rohini Sharma, Lars Wilkinson, Hrvoje Vrazic, Evan Popoff, Sandra Lopes, Steve Kanters, Eric Druyts
OBJECTIVE: Treatment intensification with additional anti-diabetic agents is recommended in type 2 diabetes (T2D) for patients inadequately controlled on metformin monotherapy. The present network meta-analysis (NMA) evaluated comparative efficacy and safety of once-weekly semaglutide and sodium-glucose co-transporter 2 inhibitors (SGLT-2is) in T2D patients inadequately controlled with metformin. METHODS: Randomized controlled trials with ≥20 weeks duration were searched in EMBASE, MEDLINE, and CENTRAL...
May 29, 2018: Current Medical Research and Opinion
Richard D Urman, Elaine A Böing, Victor Khangulov, Randi Fain, Brian H Nathanson, George J Wan, Belinda Lovelace, An T Pham, Jessica Cirillo
OBJECTIVES: Utilization of opioid-free analgesia (OFA) for post-surgical pain is a growing trend to counter the risks of opioid abuse and opioid-related adverse drug events (ORADEs). However, utilization patterns of OFA have not been examined. In this study, we investigated the utilization patterns and predictors of OFA in a surgical population in the United States. METHODS: Analysis of the Cerner Health Facts® database (1/2011 to 12/2015) was conducted to describe hospital and patient characteristics associated with OFA...
May 25, 2018: Current Medical Research and Opinion
Carlos Martinez, Anja Katholing, Kerstin Folkerts, Stephan Rietbrock
BACKGROUND: Venous thromboembolism (VTE) comprises deep vein thrombosis (DVT) and pulmonary embolism (PE) and is associated with significant recurrence and mortality risk. Standard VTE treatment includes at least three months anticoagulation. The objective was to describe time trends in the duration of oral anticoagulation in patients initially treated with vitamin K antagonists (VKAs). METHODS: A retrospective cohort study was conducted on patients with first VTE and VKA treatment initiation within 30 days, identified from the UK Clinical Practice Research Datalink from 2001 to 2014...
May 25, 2018: Current Medical Research and Opinion
Yi-Ju Lin, Chin-Yuan Wang, Ssu-Wei Cheng, Yu Ko
BACKGROUND: As the prevalence of diabetes mellitus (DM) continues to increase rapidly, there has been a rising need not only to assess the clinical outcomes but also the impact of DM on the health-related quality of life (HRQoL) of affected individuals. Most previous studies have found that having complications is strongly associated with decreased HRQoL in DM patients. As such, it is crucial to measure individuals' preferences for DM-related complications in order to assess the magnitude of complications' effect on overall HRQoL...
May 25, 2018: Current Medical Research and Opinion
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