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Current Medical Research and Opinion

Jan-Peer Elshoff, Lars Bauer, Nadine Goldammer, Marga Oortgiesen, Hanna Pesch, Lars Timmermann
OBJECTIVE: In patch-based transdermal drug delivery, adhesiveness is critical for safe and effective treatment, especially in Parkinson's disease (PD) where excessive sweating is common. This study compared the adhesiveness of two transdermal patch formulations of rotigotine (improved room temperature-stable [PR2.3.1/Treatment A] and intermediate cold storage product [PR2.1.1/Treatment B]), using the largest patch size (40 cm2 ). METHODS: PD0018 (NCT02230904) was a multicenter, randomized, double-blind, crossover study...
February 20, 2018: Current Medical Research and Opinion
Michael Kennelly, Lonny Green, Nancy Alvandi, Salim Wehbe, John Joseph Smith, Scott MacDiarmid, Jeffrey Mangel, Marc Schwartz, Tamer Aboushwareb, Brian Murray
OBJECTIVE: Previous randomized controlled trials have reported a 6.1-6.9% incidence of clean intermittent catheterization (CIC) following treatment with onabotulinumtoxinA in non-neurogenic overactive bladder (OAB) patients who were inadequately managed by ≥1 anticholinergic. A multi-center retrospective chart review assessed the real-world rate of voiding dysfunction requiring catheterization. METHODS: Patients received onabotulinumtoxinA 100U (approved dose) administered by experienced injectors between January 2013 and June 2015...
February 19, 2018: Current Medical Research and Opinion
Rhiannon Kamstra, Dominic Pilon, Patrick Lefebvre, Bruno Emond, Kruti Joshi
OBJECTIVE: To compare treatment patterns and Medicaid spending between schizophrenia patients initiating once-monthly paliperidone palmitate (PP1M) and oral atypical antipsychotics (OAA) within four comorbid populations: cardiovascular disease (CVD), diabetes, hypertension, and obesity. METHODS: Five-state Medicaid data identified comorbid adults with schizophrenia initiating PP1M or OAA (index) from 09/2009 balanced with inverse probability of treatment weighting...
February 16, 2018: Current Medical Research and Opinion
Hani Oweira, Anwar Giryes, Meinrad Mannhart, Rolf Schlumpf, Michael Decker, Omar Abdel-Rahman
BACKGROUND: The current study evaluates the prognostic value of the 8 th edition of the American Joint Committee on Cancer (AJCC) staging system for patients with anal carcinoma. PATIENTS AND METHODS: Surveillance, Epidemiology and End Results (SEER) database (2004-2014) was explored and AJCC 6 th and 8 th stages were formulated. Through Kaplan-Meier analysis, overall survival analyses were performed. The Cox regression model (adjusted for age, gender, histology, ethnicity, sub-site, and grade) was calculated for cancer-specific survival and subsequently, pairwise comparisons of hazard ratios were calculated...
February 16, 2018: Current Medical Research and Opinion
Yutaka Seino, Takashi Sasaki, Atsushi Fukatsu, Hisae Imazeki, Hidekazu Ochiai, Soichi Sakai
OBJECTIVE: To evaluate the efficacy and safety of luseogliflozin in Japanese patients with type 2 diabetes (T2D) inadequately controlled with insulin monotherapy. METHODS: This 52-week multicenter study entailed a 16-week, double-blind period followed by a 36-week, open-label period. Patients were randomized to receive either luseogliflozin 2.5 mg (n = 159) or placebo (n = 74) during the double-blind period. All patients who entered the open-label period received luseogliflozin...
February 15, 2018: Current Medical Research and Opinion
Cătălin Codreanu, Klára Šírová, Katerina Jarošová, Anastas Batalov
OBJECTIVE: To assess the effectiveness and safety of infliximab biosimilar, CT-P13, administered in a real-life setting to adult patients with active rheumatoid arthritis (RA) or ankylosing spondylitis (AS). METHODS: This multicentre, non-interventional, observational study was conducted in Bulgaria, Czech Republic and Romania. A total of 151 patients with severe active RA (n = 81) or AS (n = 70) were enrolled and treated with CT-P13 for 24 weeks, according to current medical recommendations...
February 13, 2018: Current Medical Research and Opinion
John F P Bridges, Ellen M Janssen, Andrea Ferris, Sydney M Dy
OBJECTIVE: Incorporating the patient perspective into lung cancer research, policy and treatment is becoming increasingly recognized as important. This project sought to create an engagement partnership with lung cancer patient advocates and to explore their views on transforming lung cancer healthcare systems, treatment, and policy to be more patient centered. METHODS: A patient action committee (PAC) of patient advocates living with lung cancer was engaged through group meetings, in-person and phone interviews, and email correspondence...
February 12, 2018: Current Medical Research and Opinion
Mark Peyrot, Timothy S Bailey, Belinda P Childs, Gérard Reach
INTRODUCTION: Type 2 diabetes mellitus (T2D) is a growing global epidemic. Due to the progressive nature of the disease, many people with T2D require insulin at some point, most commonly a long-acting (basal) insulin to assist with 24-hour control of glucose levels. OBJECTIVE: This opinion paper provides an overview of considerations for primary care providers (PCPs) in intensifying the treatment regimen when basal insulin therapy is inadequate. RESULTS: Control of mealtime hyperglycemia, in addition to fasting hyperglycemia, has been shown to be crucial in reaching A1c goals of <7...
February 12, 2018: Current Medical Research and Opinion
Po-Hsun Chen, Jun-Sing Wang, Shih-Yi Lin, Cheng-Hung Li, Chi-Yen Wang, Jing-Yun Hu, Chia-Po Fu, Yi-Ting Tsai, Ang-Tse Lee, Yu-Wei Chen, Yu-Hsuan Li, Chia-Lin Lee
OBJECTIVE: To investigate the effects of statins on all-cause mortality risk at different low-density lipoprotein cholesterol (LDL-C) levels and to compare the mortality risk between statin users and nonusers with identical LDL-C levels in a type 2 diabetes cohort. METHODS: In total, 10,582 outpatients aged ≥ 18 years with type 2 diabetes mellitus (T2DM) between 2009 and 2012 were enrolled in this retrospective cohort study in central Taiwan. All-cause mortality events were followed up until the end of 2014...
February 12, 2018: Current Medical Research and Opinion
Gary Middleton, Cesare Gridelli, Filippo De Marinis, Jean-Louis Pujol, Martin Reck, Rodryg Ramlau, Barbara Parente, Thierry Pieters, Carla M Visseren-Grul, Bélen San Antonio, William J John, Annamaria Hayden Zimmermann, Nadia Chouaki, Luis Paz-Ares
OBJECTIVES: To assess the long-term pemetrexed maintenance therapy on patients' renal function. METHODS: In the PARAMOUNT Phase III trial (NCT 00789373), pemetrexed was compared with placebo as maintenance treatment in advanced nonsquamous non-small-cell lung cancer patients who completed 4 cycles of pemetrexed plus cisplatin induction therapy. To evaluate changes in renal function during pemetrexed continuation maintenance treatment, we retrospectively analyzed changes in serum creatinine (sCr), treatment-emergent adverse events, dose delays, and treatment discontinuations associated with impaired renal function...
February 9, 2018: Current Medical Research and Opinion
Amelia Licari, Gian Luigi Marseglia
No abstract text is available yet for this article.
February 8, 2018: Current Medical Research and Opinion
Ilaria Soave, Roberto Marci
No abstract text is available yet for this article.
February 8, 2018: Current Medical Research and Opinion
Prithviraj Bose, Mahesh Swaminathan
No abstract text is available yet for this article.
February 8, 2018: Current Medical Research and Opinion
Leopold Eberhart, Götz Geldner, Susanne Huljic, Kerstin Marggraf, Thomas Keller, Tilo Koch, Peter Kranke
OBJECTIVE: To compare the effectiveness of 20:1 cafedrine/theodrenaline approved for use in Germany to ephedrine in the restoration of arterial blood pressure and on postoperative outcomes in patients with intraoperative arterial hypotension of any origin under standard clinical practice conditions. METHODS AND RESULTS: 'HYPOTENS' is a national, multicenter, prospective, open-label, two-armed, non-interventional study. Effectiveness and post-operative outcome following cafedrine/theodrenaline or ephedrine therapy will be evaluated in two cohorts of hypotensive patients...
February 7, 2018: Current Medical Research and Opinion
Xiaoning Chen, Qianxi Li, Xiaoye Wang, Jing Chen, Wen Lv, Bin Shi, Hong Wang, Jianru Luo, Jian Li
BACKGROUND: To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction and 6 month continuity rates associated with the 52 mg levonorgestrel intrauterine system (LNG-IUS) and the copper intrauterine device (Cu-IUD) inserted immediately after abortion. METHODS: This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and followed up to 6 months...
February 7, 2018: Current Medical Research and Opinion
Kathleen Lang, Hiep Nguyen, Huan Huang, Elise Bauer, Philip Levin
AIM: Exenatide twice daily (EBID) and mealtime insulin are effective add-on therapies to basal insulin for type 2 diabetes patients in clinical trials. This study used electronic medical record (EMR) data to evaluate analogous real-world clinical responses. MATERIALS AND METHODS: Adult patients initiating EBID or mealtime insulin as add-on to basal insulin during January 2008 - March 2013 were identified in a U.S. EMR database. EBID patients were propensity score matched 1:1 to mealtime insulin patients...
February 2, 2018: Current Medical Research and Opinion
Alisha Couto, Emanuel Troullos, Jennifer Moon, Alberto Paredes-Diaz, Robert An
OBJECTIVES: Current osteoarthritis therapies aim to alleviate pain and maintain joint function. Non-prescription oral non-steroidal anti-inflammatory drugs are frequently used alone for pain relief in osteoarthritis. This post hoc pooled analysis evaluated the analgesic efficacy and safety of two non-prescription doses of naproxen sodium for short-term use in patients with osteoarthritis of the knee or hip. A separate subgroup analysis of older patients who were administered a lower dose of naproxen sodium was performed...
February 2, 2018: Current Medical Research and Opinion
Natasa Kovac, Mladen Peric
BACKGROUND AND OBJECTIVE: Liver function assessment in patients with intra-abdominal hypertension (IAH) after major abdominal surgery is complex and often confounding. Elevated intra-abdominal pressure (IAP) often occurs after major abdominal surgery and is associated with decreased abdominal blood flow and organ dysfunction, and it could cause abdominal compartment syndrome (ACS), which is a life-threatening condition. Plasma disappearance rate (PDR) of indocyanine green (ICG) and ICG retention rate after 15 minutes (R15) were used to evaluate liver function and as a prognostic parameter after major abdominal surgery...
February 1, 2018: Current Medical Research and Opinion
Emilio Márquez-Contreras, Nieves Martell-Claros, Sara Márquez-Rivero, Enrique Hermida-Campa, Carmen Gracia-Diez, Eugenio Sanchez-López, Vicente Gil-Guillén
OBJECTIVE: To assess the efficacy of a mixed intervention, educational and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). METHODS: Prospective, longitudinal, multicenter study, carried out in 110 specialized healthcare centers in Spain. 726 patients treated with dabigatran prescribed for stroke prevention were included. A cluster randomization was performed based on two groups: 1) Control Group (CG) as usual clinical practice and Intervention Group (IG) with a mixed strategy: a) Healthcare education and b) Use of a reminder calendar for taking the anticoagulant medication...
January 31, 2018: Current Medical Research and Opinion
John Lidemberto Cardenas, Carlos Guerrero
Despite medical advances, the diagnosis and management of acute intermittent porphyria continues to be challenging. Acute pain is one of the most important clinical manifestations in acute intermittent porphyria, but management and pain assessment have been poorly studied in these patients. The lack of information and evidence based recommendations regarding these topics in the medical literature is certainly surprising. Furthermore, pain management is discussed based on extrapolating concepts adopted for other pain syndromes...
January 31, 2018: Current Medical Research and Opinion
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