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Current Medical Research and Opinion

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https://www.readbyqxmd.com/read/28812918/tyrosine-kinase-inhibitors-for-advanced-or-metastatic-thyroid-cancer-a-meta-analysis-of-randomized-controlled-trials
#1
Jen-Wei Liu, Chiehfeng Chen, El-Wui Loh, Chun-Cheng Chu, Mu-Yi Wang, Hsin-Ju Ouyang, Ya-Ting Chang, Wei-Zhan Zhuang, Ching-Wen Chou, Der-Jr Huang, Chia-Hwa Lee, Yun Yen, Ka-Wai Tam
BACKGROUND AND AIMS: Radioiodine-refractory advanced or metastatic thyroid cancer has poor prognosis. We conducted a meta-analysis of randomized controlled trials to evaluate the effectiveness and safety of tyrosine kinase inhibitors (TKIs) for advanced or metastatic thyroid cancer treatment. METHODS: Studies published until April 2017 were selected. The pooled effect size was calculated through meta-analysis by using random effects models. Outcomes were overall survival (OS), progression-free survival (PFS), objective response rate (RR), and adverse events (AEs)...
August 16, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28812376/probiotic-nomenclature-matters-redux-confusion-on-bifidobacterium-longum-subsp-infantis-taxonomy-persists
#2
David A Mills
No abstract text is available yet for this article.
August 16, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28749239/methodological-issues-in-a-meta-analysis
#3
Seyed Mohammad Riahi, Yaser Mokhayeri
No abstract text is available yet for this article.
August 16, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28737467/once-weekly-oral-antidiabetic-agent-and-treatment-satisfaction
#4
Mitsuyoshi Takahara, Toshihiko Shiraiwa, Naoto Katakami, Taka-Aki Matsuoka, Iichiro Shimomura
No abstract text is available yet for this article.
August 16, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28728515/the-prevalence-of-constipation-at-admission-and-after-1-week-of-palliative-care-a-multi-center-study
#5
Sebastiano Mercadante, Francesco Masedu, Marco Maltoni, Daniela De Giovanni, Luigi Montanari, Cristina Pittureri, Raffaella Bertè, Laura Ursini, Franco Marinangeli, Federica Aielli
AIM: To assess the prevalence and intensity of constipation in advanced-cancer patients referred to palliative care, and to assess changes after 1 week of specialist palliative care. METHODS: This was a prospective multi-center study in advanced patients for a period of 1 year. At admission (T0), age, gender, primary tumor, concomitant diseases, Karnofsky status, Palliative prognostic score (PaP), Edmonton Symptom Assessment scale (ESAS), Memorial Delirium Assessment Scale (MDAS), and bowel function index (BFI) were collected...
August 16, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28724310/non-guideline-recommended-prescribing-of-proton-pump-inhibitors-implications-for-the-future-and-reducing-over-usage
#6
Brian Godman, Joseph Fadare
Drs Godman and Fadare review the paper by Mares-Garcia and colleagues in Spain regarding the extent of non-guideline recommended prescribing (NGRP) of proton pump inhibitors (PPIs) in ambulatory care. NGRP of PPIs is an increasing public health concern given the implications of overuse of PPIs on infection rates, osteoporosis and chronic kidney disease as well as increasing polypharmacy rates. Costs are less of an issue especially where there are low prices for generic PPIs; the main focus is on improving the quality of PPI prescribing...
August 16, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28805471/prolonged-release-oxycodone-and-naloxone-treatment-counteracts-opioid-induced-constipation-in-patients-with-severe-pain-compared-to-previous-analgesic-treatment
#7
Gineke Koopmans-Klein, Joeri Van Op den Bosch, Yvonne van Megen, Hans Prenen, Frank Huygen, Isabelle Mancini
OBJECTIVE: Treatment with prolonged-release oxycodone/naloxone (PR OXN) has been shown to improve opioid induced constipation (OIC) in constipated patients. This publication reports on a real-life observational study investigating the efficacy of PR OXN with regard to bowel function in patients switching to PR OXN from WHO-step 1, step 2 and step 3 opioids. METHODS: Patients with chronic pain experiencing insufficient pain relief and/or unacceptable side effects were switched to PR OXN and monitored in this observational study with respect to efficacy regarding bowel function and efficacy regarding pain relief in comparison with previous analgesic therapy...
August 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28805468/long-term-persistence-with-single-pill-fixed-dose-combination-therapy-versus-two-pills-of-amlodipine-and-perindopril-for-hypertension-australian-experience
#8
Leon A Simons, Eric Chung, Michael Ortiz
OBJECTIVE: To study treatment persistence and mortality using a single-pill, fixed-dose combination tablet compared with a two-pill combination for hypertension. RESEARCH DESIGN AND METHODS: We analyzed Australian Pharmaceutical Benefit Scheme records 2011-2014 in a 10% random sample of concessional patients prescribed concomitant amlodipine and perindopril - either as a single-pill, fixed-dose combination tablet (n = 9340) or as two-pill combination therapy (n = 3093)...
August 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28799429/giving-adherence-intervention-programs-their-due
#9
Elizabeth J Unni, Lisa K Sharp
No abstract text is available yet for this article.
August 11, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28795870/positive-predictive-value-between-medical-chart-body-mass-index-category-and-obesity-versus-codes-in-a-claims-data-warehouse
#10
Eleanor O Caplan, Pravin S Kamble, Raymond A Harvey, B Gabriel Smolarz, Andrew Renda, Jonathan R Bouchard, Joanna C Huang
OBJECTIVE: To evaluate the positive predictive value of claims-based V85 codes for identifying individuals with varying degrees of BMI relative to their measured BMI obtained from medical record abstraction. METHODS: This was a retrospective validation study utilizing administrative claims and medical chart data from 1/1/2009 to 8/31/2015. Randomly selected samples of patients enrolled in a Medicare Advantage Prescription Drug (MAPD) or commercial health plan and with a V85 claim were identified...
August 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28787217/ldl4-a-novel-predictor-of-coronary-artery-disease-severity
#11
Rahul Chaudhary, Denny Mathew, Kevin Bliden, Udaya S Tantry, Tushar Sharma, Martin G Gesheff, Christopher J Franzese, Shachi Pandya, Peter P Toth, Paul A Gurbel
BACKGROUND: Hyperlipidemia is a well-established risk factor for coronary artery disease (CAD). Severe CAD has been observed in patients with normal levels of total and LDL cholesterol. Small-dense LDL particle subtypes (LDL3 and LDL4) have been observed to be more oxidizable and atherogenic. We aimed to identify the role of cholesterol particle subtypes in predicting CAD severity. METHODS: Blood samples were obtained immediately before cardiac catheterization in 179 consecutive patients with suspected CAD...
August 8, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28748721/real-world-costs-and-outcomes-in-metastatic-renal-cell-carcinoma-patients-treated-with-targeted-therapies-a-cohort-study-from-the-french-health-insurance-database
#12
Rana Maroun, Laetitia Fleury, Gaelle Nachbaur, Franck Maunoury, Jean-Louis Vanhille, Isabelle Durand-Zaleski
OBJECTIVES: The objective of this study was to describe treatment patterns, survival, healthcare use and costs in patients with metastatic renal cell carcinoma (mRCC) in a real-world setting. RESEARCH DESIGN AND METHODS: We used the National Health Insurance (NHI) claims database for the Ile-de-France region to perform a retrospective cohort analysis of patients with mRCC treated by a first-line targeted therapy. Treatment naïve patients were identified combining the 10th revision of the International Classification of Diseases (ICD-10) codes (C64 & C77-C79) and a first prescription of targeted therapies...
August 7, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28776439/visceral-adipose-tissue-is-more-strongly-associated-with-insulin-resistance-than-subcutaneous-adipose-tissue-in-chinese-subjects-with-prediabetes
#13
Lin Liu, Jitao Feng, Gong Zhang, Xiaodan Yuan, Fan Li, Tingting Yang, Shujie Hao, Dejian Huang, Cunyi Hsue, Qinging Lou
AIMS: To investigate the value of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in a cohort of community's residents who were diagnosed as prediabetes, and to evaluate the association of VAT and SAT with insulin resistance. METHODS: This study was based on cross-sectional analysis of data from 107 adults. VAT and SAT were assessed by computed tomography. Insulin resistance was defined by homeostasis model assessment of insulin resistance >2...
August 4, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28771049/direct-oral-anticoagulants-in-the-treatment-of-pulmonary-embolism
#14
Joanna B Eldredge, Alex C Spyropoulos
OBJECTIVE: The objective of this review is to examine the management strategies for pulmonary embolism (PE) with an emphasis of the role of direct oral anticoagulants (DOACs). METHODS: PubMed was searched to identify relevant journal articles published through April 2017. Additional references were obtained from articles discovered during the database search. RESULTS: Initial heparinization followed by long-term anticoagulation with vitamin K antagonists (VKAs) has been considered the mainstay for the treatment of PE...
August 3, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28766382/heart-rate-control-is-associated-with-the-reduced-cardiovascular-events-in-asian-patients-with-coronary-artery-disease-treated-with-bisoprolol-biso-cad-results-from-a-multi-national-real-world-experience
#15
Yundai Chen, Xinchun Yang, Vinh Nguyen Pham, Shian Huang, Guosheng Fu, Xiaoping Chen, Binh Quang Truong, Yu Yang, Shaowen Liu, Xuan Chen, Tianrong Ma, Dong-Soo Kim, Tae-Hoon Kim
OBJECTIVE: To evaluate the association between decrease in resting heart rate (RHR) and occurrence of composite cardiac clinical outcomes in coronary artery disease (CAD) patients after bisoprolol treatment. METHODS: This phase IV, multi-national, single-arm, open-label, non-randomized, observational trial was conducted between October 2011 to April 2014 across 40 hospitals from China, South Korea and Vietnam. RESULTS: Analysis of 866 patients (mean age 63...
August 2, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28760003/surgical-outcomes-of-laparoscopic-endometriosis-surgery-a-6-year-experience
#16
S Alborzi, A Hosseini-Nohadani, T Poordast, Z Shomali
OBJECTIVES: The aim of the present study was to review 6-year experience on the surgical outcomes of laparoscopic endometriosis surgery. METHODS: A cohort study was performed in Shiraz University of Medical Sciences using data from medical records of 1315 cases of patients with endometriosis undergoing laparoscopic surgery with follow-up of 6 to 72 months. RESULTS: This study concerned a cohort of 1315 patients diagnosed with endometriosis operated between April 2010 and April 2016, 1086 (82...
August 1, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28760001/association-of-obesity-with-healthcare-utilization-and-costs-in-a-medicare-population
#17
Brandon T Suehs, Pravin Kamble, Joanna Huang, Mette Hammer, Jonathan Bouchard, Mary E Costantino, Andrew Renda
OBJECTIVES: To examine the association of obesity on healthcare resource utilization and costs in a Medicare population. METHODS: This study was a retrospective cohort study using Humana Medicare Advantage (MA) claims data. Body mass index (BMI) was assessed using ICD-9-CM status codes (V85 hierarchy) that have been validated in the data source to classify patients into BMI categories: Normal (N), Overweight (Ow), Obese class I (ObI), Obese class II (ObII), and Obese class III (ObIII)...
August 1, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28758813/medication-safety-knowledge-attitudes-and-practices-among-community-pharmacists-in-lebanon
#18
Aline Hajj, Souheil Hallit, Elsy Ramia, Pascale Salameh
BACKGROUND: The effectiveness of a national post-marketing surveillance program depends directly on the active participation of all health professionals. There is no current comprehensive and active pharmacovigilance program available in Lebanon. OBJECTIVES: To assess the knowledge, attitudes, and practices (KAP) among community pharmacists in Lebanon in relevance to potential pharmacovigilance and adverse-drug-reactions reporting in Lebanon. METHODS: A cross-sectional descriptive study, using a self-administered KAP questionnaire and conducted between March and July 2016, included 1857 pharmacists practicing in community settings...
July 31, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28758802/characteristics-of-antimuscarinic-responders-versus-suboptimal-responders-in-a-randomized-clinical-trial-of-patients-with-overactive-bladder-symptoms
#19
Lars Grenabo, Sender Herschorn, Steven A Kaplan, Linda Cardozo, David Scholfield, Daniel Arumi, Martin Carlsson, Douglass Chapman, Fady Ntanios
OBJECTIVE: To assess the characteristics of tolterodine extended-release (ER) 4 mg responders and suboptimal responders (≤50% decrease in UUI episodes/24 h) among patients with overactive bladder (OAB), including urgency urinary incontinence (UUI), and identify predictors of a >50% UUI response with fesoterodine 8 mg in tolterodine suboptimal responders. METHODS: Adult patients with OAB symptoms for ≥6 months and ≥8 micturitions, and ≥2 and <15 UUI episodes/24 h at week -2 received open-label tolterodine ER 4 mg during a 2-week run-in...
July 31, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28756684/limitations-of-traditional-health-technology-assessment-methods-and-implications-for-the-evaluation-of-novel-therapies
#20
Jason Doctor, Joanna P MacEwan
No abstract text is available yet for this article.
July 31, 2017: Current Medical Research and Opinion
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