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Current Medical Research and Opinion

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https://www.readbyqxmd.com/read/29243513/evaluation-of-health-care-costs-and-utilization-for-patients-with-gout-a-population-based-matched-cohort-study
#1
Yi-Yun Lee, Chao-Hsiun Tang, Jin-Hua Chen, Li-Na Kuo, Yu Ko
OBJECTIVES: To better understand the economic burden of gout patients in Taiwan, we conducted a nationwide retrospective study to compare the healthcare costs and utilization between gout and gout-free patients. METHODS: The Longitudinal Health Insurance Database (LHID) 2010 was used to identify gout cases and matched gout-free controls. Gout cases were defined as having (1) at least three instances of diagnoses of gout on medical claims or (2) one diagnosis of gout with at least one gout-related pharmacy claim in 2011...
December 15, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29243497/preventing-recurrent-events-in-survivors-of-acute-coronary-syndromes-in-australia-consensus-recommendations-using-the-delphi-process
#2
Christopher J Hammett, John Amerena, David Brieger, Andrew Sindone, Peter L Thompson, Matthew I Worthley, Philip E Aylward
OBJECTIVE: There remain substantial gaps in implementation of evidence-based care in patients with acute coronary syndromes (ACS) in Australia, which contribute to high recurrent event rates. Improved translation of evidence into effective action is a key health-care priority. We engaged cardiovascular experts from across Australia to develop straightforward, easily actionable recommendations on key medications to use following ACS. METHODS: An eight-person steering committee (SC) reviewed the published evidence and developed an initial set of statements to be developed into consensus recommendations using a modified Delphi technique...
December 15, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29239679/primary-care-variability-in-patients-at-higher-risk-for-colorectal-cancer-evaluation-of-screening-and-preventive-care-practices
#3
John Peabody, Juan-Sebastien Salvidar, Eric Swagel, Steven Fugaro, David Paculdo, Mary Tran
OBJECTIVE: Sub-optimal colorectal cancer (CRC) evaluations have been attributed to both physician and patient factors. The primary objective of this study was to evaluate physician practice variation in patients with a higher risk of CRC. We wanted to identify the physician characteristics and the types of patient that were associated with missed screening opportunities; we also explored whether screening for CRC served as a proxy for better preventive care practices. METHODS: 213 board-certified family and internal medicine physicians participated in the study, conducted between September and December 2016...
December 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29239678/the-effect-of-antibiotic-prophylaxis-for-acute-pelvic-inflammatory-disease-after-hysterosalpingography-a-retrospective-cohort-study
#4
Hao-Ming Li, Fung-Chang Sung, Shang-Chieh Li, Ying-Kai Huang, Yu Chang, Chi-Chang Chang, S Joseph Huang, Cheng-Li Lin, Chia-Hung Kao
AIMS: The concern about acute pelvic inflammatory disease (PID) after hysterosalpingography (HSG) has been raised since 1980. However, the effectiveness of prophylactic antibiotics remains unclear. This study investigated the effect of antibiotic prophylaxis in women undergoing HSG. METHODS: Women undergoing HSG between 2000 and 2012 were screened from Taiwan National Health Insurance Research Database for eligibility. The prophylactic cohort included patients using any antibiotics of 1st-generation cephalosporins, doxycycline, clindamycin, and metronidazole, within seven days before HSG (N = 3257)...
December 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29239664/efficacy-and-safety-of-twice-daily-sustained-release-paracetamol-formulation-for-osteoarthritis-pain-of-the-knee-or-hip-a-randomized-double-blind-placebo-controlled-twelve-week-study
#5
Kenneth Reed, Agron Collaku, Sebastian Moreira
OBJECTIVE: Evaluate efficacy and safety of an investigational, twice-daily sustained-release (SR) paracetamol formulation in subjects with knee or hip osteoarthritis (OA). METHODS: In this multicenter, double-blind, parallel study (NCT02311881), subjects with hip or knee OA were randomly assigned to SR paracetamol 2x1000 mg BID, extended-release (ER) paracetamol 2x665 mg TID, or placebo for 12 weeks. Primary endpoint was mean change from baseline through 12 weeks in WOMAC Osteoarthritis Index pain...
December 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29235900/treatment-and-discharge-patterns-among-patients-hospitalized-with-non-valvular-atrial-fibrillation-transitioning-from-the-inpatient-to-outpatient-setting
#6
Henry J Henk, Feng Cao, Kenneth Tuell, Kwanza Price, Prianka Singh, Jack Mardekian, Kevin Odell, Chad Patel, Wilson Tan, George H Sands, Shalabh Singhal, Jeffrey Trocio, Lien Vo
OBJECTIVE: To evaluate inpatient oral anticoagulant (OAC) treatment, discharge location, and post-discharge OAC treatment for patients hospitalized with non-valvular atrial fibrillation (NVAF). RESEARCH DESIGN AND METHODS: Retrospective study using claims data linked to hospital electronic health records (EHR). Patients (N = 2,484) were hospitalized with a primary (38%) or secondary (62%) diagnosis of AF without evidence of mitral valvular heart disease or valve replacement between January 2009 and September 2013...
December 13, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29235884/cost-per-successfully-treated-patient-for-vortioxetine-versus-duloxetine-in-adults-with-major-depressive-disorder-an-analysis-of-the-complete-symptoms-of-depression-and-functional-outcome
#7
Michael Cronquist Christensen, Vicki Munro
OBJECTIVE: To determine the cost-effectiveness of vortioxetine versus duloxetine in adults with moderate to severe major depressive disorder (MDD) in Norway using a definition of a successfully treated patient (STP) that incorporates improvement in both mood symptoms and functional capacity. METHODS: Using the population of patients who completed the 8-week CONNECT study, the cost-effectiveness of vortioxetine (n = 168) (10-20 mg/day) versus duloxetine (n = 176) (60 mg/day) was investigated for the treatment of adults in Norway with moderate to severe MDD and self-reported cognitive dysfunction over an 8-week treatment period...
December 13, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29231750/concordance-with-prescribing-information-dosage-recommendations-for-dipeptidyl-peptidase-4-inhibitors-among-type-2-diabetes-mellitus-patients-with-moderate-to-severe-chronic-kidney-disease
#8
Huan Huang, Sharash Shetty, Elise Bauer, Kathleen Lang
OBJECTIVE: To estimate the proportion of patients with moderate to severe chronic kidney disease (CKD) whose initial DPP4-i dosage was concordant with prescribing information (label) recommendations in the United States. METHODS: Adult patients with T2DM who initiated a DPP4-i (linagliptin, sitagliptin, saxagliptin) between Jan 1, 2011 and Jun 30, 2014 were identified using electronic medical records and administrative claims, with index date being the date of first observed DPP4-i treatment...
December 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29231748/relationship-between-patient-copayments-in-medicare-part-d-and-vaccination-claim-status-for-herpes-zoster-and-tetanus-diphtheria-acellular-pertussis
#9
Songkai Yan, Maral DerSarkissian, Rachel H Bhak, Patrick Lefebvre, Mei Sheng Duh, Girishanthy Krishnarajah
OBJECTIVE: To assess the relationship between copay amount and vaccination claim submission status for tetanus-diphtheria-acellular pertussis (Tdap) and herpes zoster (GSK study identifier: HO-14-14319). METHODS: Retrospective analyses were performed using vaccination administrative claims data in patients aged ≥65 years with ≥1 claim for Tdap or zoster vaccines between 2012-2014. To avoid confounding by other financial responsibility, analyses were conducted among patients in the copayment phase of insurance...
December 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29231746/is-there-a-role-for-charcoal-in-palliative-diarrhea-management
#10
Helen Senderovich, Megan J Vierhout
OBJECTIVE: Symptomatic therapy is an intervention centred entirely on the symptom management and pain relief. The utilization of charcoal in diarrhea management is a pertinent example of this type of medical care. Diarrhea is an ailment defined as an escalation in the frequency of bowel movements, unformed stool, abdominal discomfort and pain. These symptoms can be extremely debilitating for patients and effectuate frustration as well as severely damping mood and overall well-being. This narrative review aims to explore the use of charcoal in diarrhea management and its possible benefits in alleviating discomfort associated with these symptoms...
December 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29231073/pelargonium-sidoides-preparation-eps-7630-in-copd-health-related-quality-of-life-and-other-patient-reported-outcomes-in-adults-receiving-add-on-therapy
#11
Heinrich Matthys, Petra Funk
OBJECTIVE: Patient-reported outcomes (PRO) such as health-related quality of life (HRQL) belong to the most important criteria for the evaluation of medical therapies in clinical trials or practice-based benefit assessments. We therefore revisited results of an earlier published clinical trial investigating the effects of the herbal drug preparation from the roots of Pelargonium sidoides EPs 7630, administered as add-on therapy in patients suffering from chronic obstructive pulmonary disease (COPD), with respect to HRQL and other PRO...
December 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29224367/effect-of-ruxolitinib-therapy-on-the-quality-of-life-of-japanese-patients-with-myelofibrosis
#12
Kenji Oritani, Kohshi Ohishi, Shinichiro Okamoto, Keita Kirito, Norio Komatsu, Tetsuzo Tauchi, Hiroshi Handa, Shigeki Saito, Katsuto Takenaka, Kazuya Shimoda, Hikaru Okada, Taro Amagasaki, Shiho Wakase, Kojiro Shimozuma, Koichi Akashi
OBJECTIVES: Myelofibrosis (MF) is associated with a significant symptom burden that severely impacts patient quality of life (QOL). Ruxolitinib, a potent Janus kinase 1 (JAK1)/JAK2 inhibitor, led to substantial improvements in splenomegaly, MF-associated symptoms, and QOL in the phase 3 COMFORT studies, proving superior to placebo and best available therapy. We evaluated the effect of ruxolitinib on symptoms and QOL in Japanese patients with MF. METHODS: We conducted a pooled analysis of studies A2202 (NCT01392443) and AJP01 (NCT02087059) of ruxolitinib in Japanese patients with MF (N = 81)...
December 9, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29219621/clinical-trial-transparency-update-an-assessment-of-the-disclosure-of-results-of-company-sponsored-trials-associated-with-new-medicines-approved-in-europe-in-2014
#13
Bryan R Deane, Sheuli Porkess
BACKGROUND: The objective of this study was to assess the timely disclosure of results of company-sponsored clinical trials related to all new medicines approved by the European Medicines Agency (EMA) during 2014. This is the final extension of three previously reported studies of trials related to all new medicines approved in Europe in 2009, 2010 and 2011, and in 2012 and 2013. The original study found that over a three-year period over three-quarters of all trials were disclosed within 12 months and almost 90% were disclosed by the end of the study (31 Jan 2013)...
December 8, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29219620/a-common-humoral-background-of-intraocular-and-arterial-blood-pressure-dysregulation
#14
Janusz Skrzypecki, Iwona Grabska-Liberek, Joanna Przybek, Marcin Ufnal
It has been postulated that intraocular pressure, an important glaucoma risk factor, correlates positively with arterial blood pressure (blood pressure). However, results of experimental and clinical studies are often contradictory. We hypothesize that in some hypertensive patients, disturbances in intraocular pressure regulation may depend on biological effects of blood borne hormones underlying a particular type of hypertension, rather than on blood pressure level itself. This review compares the effects of hormones on blood pressure and intraocular pressure, in order to identify a hormonal profile of hypertensive patients with an increased risk of intraocular pressure surge...
December 8, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29210288/efficacy-and-effectiveness-of-valsartan-amlodipine-and-valsartan-amlodipine-hydrochlorothiazide-in-hypertension-randomized-controlled-versus-observational-studies
#15
Jorge Sison, Rosa María Ríos Vega, Hu Dayi, Giovanni Bader, Patrick Brunel
OBJECTIVE: The aim of this post-hoc analysis was to compare the results from randomized-controlled trials (RCTs) and real-world evidence (RWE) studies of valsartan/amlodipine (Val/Aml) and valsartan/amlodipine/hydrochlorothiazide (Val/Aml/HCTZ) in patients with uncontrolled hypertension (>140/90 mmHg). METHODS: Data were pooled from 15 RCTs (N = 5542), 8 RWE studies (N = 1397) for Val/Aml; and 2 RCTs (N = 804), 5 RWE studies (N = 9380) for Val/Aml/HCTZ...
December 6, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29023146/is-there-a-role-for-combined-use-of-gabapentin-and-pregabalin-in-pain-control-too-good-to-be-true
#16
Helen Senderovich, Geetha Jeyapragasan
Gabapentin (Neurontin 1 ) and pregabalin (Lyrica 2 ) are first- and second-generation α2δ ligands, respectively, and are both approved for use as adjunctive therapy in pain control. Although they do not bind to gamma-aminobutyric acid (GABA) receptors they have been successfully used to treat neuropathic pain conditions. Their mechanism of action is not yet fully understood, but research has demonstrated promising results. Despite their similarities, they have been used in combination in both clinical and research situations, and have been noted to have a synergistic effect in pain control without concern for clinically significant pharmacokinetic interactions...
December 4, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29195485/post-allograft-relapse-of-all-rational-use-of-the-new-targeted-therapies
#17
Caroline L Furness, David I Marks
No abstract text is available yet for this article.
December 1, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29192528/hospitalization-costs-and-resource-allocation-in-cholecystectomy-with-use-of-intravenous-versus-oral-acetaminophen
#18
Ryan N Hansen, An T Pham, Elaine A Böing, Belinda Lovelace, George J Wan, Donna A Thomas, Manuel L Fontes
OBJECTIVE: To evaluate intravenous (IV) acetaminophen (APAP) vs. oral APAP use as adjunctive analgesics in cholecystectomy patients by comparing associated hospital length of stay (LOS), hospital costs, opioid use, and rates of nausea/vomiting, respiratory depression, and bowel obstruction. METHODS: We conducted a retrospective analysis of the Premier Database (1/2012 to 9/2015) including cholecystectomy patients who received either IV APAP or oral APAP. We estimated differences in LOS, hospitalization costs, mean daily morphine equivalent dose (MED), and potential opioid-related adverse events...
December 1, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29189082/the-value-of-time-in-therapeutic-range-in-the-prediction-of-outcomes-at-a-populational-level-in-patients-treated-with-vitamin-k-antagonists
#19
Daniel Caldeira
No abstract text is available yet for this article.
November 30, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29188721/comparison-of-major-bleeding-risk-in-patients-with-non-valvular-atrial-fibrillation-receiving-direct-oral-anticoagulants-in-the-real-world-setting-a-network-meta-analysis
#20
S Deitelzweig, C Farmer, X Luo, X Li, L Vo, J Mardekian, K Fahrbach, A Ashaye
OBJECTIVE: To conduct a systematic literature review (SLR) and network meta-analysis (NMA) of real-world studies comparing major bleeding risk among patients with non-valvular atrial fibrillation (NVAF) on direct oral anticoagulants (DOACs) or warfarin. METHODS: Systematic searches were conducted in MEDLINE and Embase for full-text articles published between January 1, 2003 and March 18, 2017. Eligible studies compared at least two of the following in a real-world setting: warfarin, apixaban, dabigatran, rivaroxaban, or edoxaban...
November 30, 2017: Current Medical Research and Opinion
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