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Current Medical Research and Opinion

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https://www.readbyqxmd.com/read/30114983/non-pharmacologic-treatments-for-symptoms-of-diabetic-peripheral-neuropathy-a-systematic-review
#1
Suzanne Amato Nesbit, Ritu Sharma, Julie M Waldfogel, Allen Zhang, Wendy L Bennett, Hsin-Chieh Yeh, Yohalakshmi Chelladurai, Dorianne Feldman, Karen A Robinson, Sydney M Dy
OBJECTIVE: To systematically assess benefits and harm of non-pharmacologic interventions for diabetic peripheral neuropathy (DPN) symptoms. METHODS: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched from 1966 to May 24, 2016 for randomized controlled trials. Two reviewers evaluated studies for eligibility, serially abstracted data, evaluated risk of bias, and graded strength of evidence (SOE) for critical outcomes (pain and quality-of-life)...
August 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30114939/exploring-the-costs-of-a-13-valent-pneumococcal-conjugate-vaccination-program-for-home-care-patients
#2
Miika Linna, Juha Laine, Leena Timonen, Heidi Åhman, Myint Tin Tin Htar
OBJECTIVE: The city of Joensuu in Finland vaccinated 409 elderly home care patients with the 13-valent pneumococcal conjugate vaccine (PCV13) in autumn 2012. All home care patients were also eligible for a seasonal influenza vaccine. The objective of this retrospective real-world data cohort study was to evaluate if the immunization intervention with PCV13 for home care patients was cost-saving from the payer's (municipality's) perspective in terms of a return on investment (ROI). METHODS: This was a retrospective observational registry study...
August 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30112931/the-burden-of-non-infectious-intraocular-inflammatory-eye-diseases-a-systematic-literature-review
#3
J Bradford Rice, Alan G White, Lauren M Scarpati, George J Wan, Winnie W Nelson
OBJECTIVE: Non-infectious inflammatory eye diseases (IEDs), although rare, are complex and varied and may result in detrimental effects. A systematic literature review was conducted on the clinical outcome and economic burden of IED. METHODS: The Ovid search platform (Wolters Kluwer) was used to access scientific literature databases, including MEDLINE, Embase, Cochrane libraries, Health Technology Assessment, and the NHS Economic Evaluation database. The search strategy targeted clinical and economic outcomes research in 2009-2016...
August 16, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30106315/development-of-the-medication-adherence-estimation-and-differentiation-scale-meds
#4
Amod S Athavale, John P Bentley, Benjamin F Banahan, David J McCaffrey, Patrick F Pace, Douglas W Vorhies
OBJECTIVES: To develop a self-reported measure for medication adherence and compare its ability to predict proportion of days covered (PDC) with contemporary scales. METHODS: Retrospective prescription fill data from three community pharmacies in the Southeastern US were assessed to identify patients that are 18 years of age or older, and have received at least one medication for diabetes, hypertension, or dyslipidemia. A cross-sectional survey containing the Medication adherence Estimation and Differentiation Scale (MEDS), was administered among these pharmacy patrons...
August 14, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30106313/short-term-rehospitalizations-in-young-adults-with-schizophrenia-treated-with-once-monthly-paliperidone-palmitate-or-oral-atypical-antipsychotics-a-retrospective-analysis
#5
Dominic Pilon, Tony B Amos, Rhiannon Kamstra, Ameur M Manceur, Antoine C El Khoury, Patrick Lefebvre
OBJECTIVE: To compare rehospitalizations in patients with schizophrenia treated with paliperidone palmitate (PP1M) versus oral atypical antipsychotics (OAAs) with a focus on young adults (18-35 years). METHODS: The Premier Healthcare database (01/2009-12/2016) was used to identify hospitalizations of adults (≥18 years) with schizophrenia treated with PP1M or OAA between 09/2009 and 10/2016 (index hospitalizations). Rehospitalizations were assessed at 30, 60, and 90 days after each index hospitalization in young adults and in all patients...
August 14, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30106311/a-randomized-trial-comparing-omega-3-fatty-acid-plasma-levels-after-ingestion-of-emulsified-and-non-emulsified-cod-liver-oil-formulations
#6
Nelly Conus, Nicola Burgher-Kennedy, Frans van den Berg, Gurleen Kaur Datta
OBJECTIVES: Emulsified formulations of omega-3 fatty acids may increase plasma concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) compared with non-emulsified formulations. The current study evaluated plasma concentrations of DHA+EPA as well as DHA and EPA individually following administration of emulsified versus non-emulsified cod liver oil formulations. METHODS: In this randomized, 2-period, crossover study (ClinicalTrials.gov NCT02428699), 47 healthy adults received single doses of an emulsified cod liver oil formulation and a non-emulsified cod liver oil formulation, each containing 10% cod liver oil plus 10% cod oil and closely matched DHA and EPA content...
August 14, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30067119/patient-reported-treatment-satisfaction-with-rivaroxaban-in-japanese-non-valvular-atrial-fibrillation-patients-an-observational-study
#7
Yukihiro Koretsune, Koichiro Kumagai, Shinichiro Uchiyama, Takeshi Yamashita, Masahiro Yasaka, Emi Watanabe-Fujinuma, Benjamin F Banderas, Sayako Akiyama, Yutaka Okayama, Jean-Baptiste Briere, Gavin Dickie, Stefan J Cano
OBJECTIVES: Rivaroxaban has previously been shown to be as efficacious and safe as warfarin for the prevention of stroke in non-valvular atrial fibrillation (NVAF). Therefore, treatment satisfaction becomes an important consideration. Here we examine treatment satisfaction in Japanese NVAF patients who were switched from warfarin to rivaroxaban. METHODS: Patient-reported outcome (PRO) data were collected as part of a prospective, multi-center, post-marketing surveillance (PMS) of a direct oral-anticoagulant, rivaroxaban, in Japan...
August 14, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30049230/from-obesity-to-uterine-fibroids-an-intricate-network
#8
Ilaria Soave, Roberto Marci
No abstract text is available yet for this article.
August 14, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30095019/upper-gastrointestinal-bleeding-in-critically-ill-patients-ppis-h2ras-or-placebo-many-questions-remain-unanswered
#9
Guillermo García-Rayado, Angel Lanas
No abstract text is available yet for this article.
August 10, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30049226/cost-effectiveness-analysis-of-istent-trabecular-micro-bypass-stent-for-patients-with-open-angle-glaucoma-in-colombia
#10
Jaime E Ordóñez, Angélica Ordóñez, Urpy M Osorio
OBJECTIVE: To estimate the cost-effectiveness of trabecular micro bypass stent vs laser trabeculoplasty or medications only, for patients with open-angle glaucoma in a setting of the Colombian System Health. METHODS: This is a cost-effectiveness analysis that based its assumptions in external data sources, used to extrapolate the quality-of-life related to health, survival, and costs. A Markov model, with stages from 0 (ocular hypertension without glaucoma) to 5 and bilateral blindness, was developed inclusive of Colombians older than 40 years in 2018, from a societal perspective, comparing trabecular micro-bypass stents vs laser trabeculoplasty, timolol + dorzolamide + brimonidine, timolol + dorzolamide + latanoprost, or timolol + dorzolamide + brimatoprost, in terms of clinical and economic outcomes over a lifetime horizon...
August 10, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30047289/treatment-adherence-healthcare-resource-utilization-and-costs-in-patients-with-lung-neuroendocrine-tumors-lung-nets-in-the-usa
#11
Michael S Broder, Beilei Cai, Eunice Chang, Tingjian Yan, Al B Benson Iii
OBJECTIVE: To assess first-line treatment adherence, healthcare resource utilization, and costs in lung NET patients initiating pharmacologic treatments. METHODS: In two US claims databases, patients aged ≥18 years with ≥1 inpatient or ≥2 outpatient lung NET claims within 12 months were identified. The first claim for pharmacologic treatments (e.g. somatostatin analogs [SSAs], cytotoxic chemotherapy [CC], targeted therapy [TT]) following diagnosis, between July 1, 2009-December 31, 2014, was defined as the index date...
August 10, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30019594/adenocarcinoma-histology-is-a-poor-prognostic-factor-in-locally-advanced-cervical-cancer
#12
Joanna Jonska-Gmyrek, Leszek Gmyrek, Agnieszka Zolciak-Siwinska, Maria Kowalska, Beata Kotowicz
OBJECTIVE: This retrospective study aimed to compare prognostic factors and survival between adenocarcinoma (AC) and squamous cell carcinoma (SCC) in locally advanced cervical cancer treated at a single center. METHODS: All medical records of cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB or IIIA,B, treated between 2004 and 2012, were reviewed. We treated patients with chemoradiotherapy (CRT) followed by brachytherapy (BT)...
August 10, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30091647/cost-of-subcutaneous-immunotherapy-in-a-large-insured-population-in-the-united-states
#13
Jianbin Mao, Kim A Heithoff, Eleena Koep, Thomas Murphy, Eva Hammerby
OBJECTIVE: Allergic rhinitis (AR) affects up to 40% of the United States population, with approximately $11 billion annual medical costs. Allergy immunotherapy is the best option for long-term symptomatic relief, but treatment compliance can be low. The objective was to describe subcutaneous immunotherapy (SCIT)-related costs for patients overall and those with inconsistent treatment. METHODS: This study observed commercial and Medicare Advantage with Part D health plan enrollees...
August 9, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30091642/assessment-of-adherence-to-medication-in-patients-after-myocardial-infarction-treated-with-percutaneous-coronary-intervention-is-there-a-place-for-new-self-reported-questionnaires
#14
Aldona Kubica, Agata Kosobucka, Tomasz Fabiszak, Diana A Gorog, Jolanta M Siller-Matula
Non-adherence to medication regimen after myocardial infarction (MI) leads to increased morbidity and mortality and generates additional cost to the healthcare system. OBJECTIVES: The aim of this systematic review was to critically discuss assessment methods of adherence to medication in patients after myocardial infarction treated with percutaneous coronary intervention and the possible application of a new self-reported questionnaire. METHODS: A systematic investigation of all published literature was conducted to minimize the risk of bias...
August 9, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30086671/sedative-drugs-used-for-mechanically-ventilated-patients-in-intensive-care-units-a-systematic-review-and-network-meta-analysis
#15
Hongliang Wang, Changsong Wang, Yue Wang, Hongshuang Tong, Yue Feng, Ming Li, Liu Jia, Kaijiang Yu
BACKGROUND: The effects of different sedative drugs on all-cause mortality rate, duration of ICU stay, and risk of delirium in mechanically ventilated ICU patients are unclear. This meta-analysis aimed to compare the effectiveness and safety of individual sedative drugs and combined drugs in mechanically ventilated ICU patients. MATERIALS AND METHODS: MEDLINE, EMBASE, Cochrane, EBSCohost, and ISIWeb of Science databases were searched for studies that assessed sedation in ICU mechanically ventilated patients...
August 8, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30086667/strategies-to-achieve-low-density-lipoprotein-cholesterol-targets-in-high-risk-patients
#16
Chrysanthi Mantsiou, Konstantinos Tziomalos
No abstract text is available yet for this article.
August 8, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30086654/benefits-and-risks-of-ponatinib-versus-bosutinib-following-treatment-failure-of-two-prior-tyrosine-kinase-inhibitors-in-patients-with-chronic-phase-chronic-myeloid-leukemia-a-matching-adjusted-indirect-comparison
#17
Moshe Yair Levy, Lisa J McGarry, Hui Huang, Stephanie Lustgarten, Silvia Chiroli, Sergio Iannazzo
OBJECTIVE: Comparing the benefit-risk profiles of ponatinib vs. bosutinib in third-line (3L) treatment of chronic phase chronic myeloid leukemia (CP-CML) is challenging because their pivotal trials lacked comparator arms. To characterize the overall benefit-risk in 3L CP-CML patients treated with bosutinib vs. ponatinib, a matching-adjusted indirect comparison (MAIC) was performed to compare efficacy outcomes and treatment duration after adjusting for trial subjects' baseline characteristics, and tolerability was assessed with an unadjusted comparison of study-drug discontinuation...
August 8, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30084288/the-efficacy-of-pregabalin-for-treating-pain-associated-with-diabetic-peripheral-neuropathy-in-subjects-with-type-1-or-type-2-diabetes-mellitus
#18
B Parsons, C Li, B Emir, A I Vinik
OBJECTIVE: The objective of this manuscript is to compare pregabalin's efficacy and safety for painful diabetic peripheral neuropathy (pDPN) in subjects with type 1 (T1DM) or 2 diabetes mellitus (T2DM). METHODS: Pooled data from 10 randomized clinical trials (pregabalin-treated T1DM and T2DM subjects with pDPN) were analyzed for change from baseline (CFB) scores (pain and sleep disturbance) using mixed model repeated measures (MMRM) through Week 12 and last observation carried forward (LOCF)...
August 7, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29985065/bilateral-adrenal-hemorrhage-revealed-antiphospholipid-syndrome-in-a-male-patient-benefit-from-comprehensive-treatment
#19
Junqing Xu, Qin Zhou, Nihong Jiang, Zhenming Liu, Hui Gao, Yanbin Sui, Riming Liu, Pingtao Liu, Yajuan Cui
BACKGROUND: Adrenal hemorrhage caused by antiphospholipid syndrome (APS) secondary to systemic lupus erythematosus (SLE) is very rare, especially in males. REPORT: This study reports a 45-year-old male patient who presented with fatigue, loss of appetite, nausea, and vomiting for 2 months with a history of recurring epilepsy. On examination, he had low blood pressure (95/53 mmHg) and hyponatremia (117.9 mmol/L). His abdominal computed tomography (CT) scan showed bilateral diffusely enlarged adrenal hemorrhage...
August 7, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30079770/erratum
#20
(no author information available yet)
No abstract text is available yet for this article.
August 5, 2018: Current Medical Research and Opinion
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