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Current Medical Research and Opinion

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https://www.readbyqxmd.com/read/27882775/association-between-availability-of-care-providers-and-healthcare-utilizations-among-adults-with-asthma
#1
Minchul Kim, Carl V Asche, William Tillis, Jinma Ren
BACKGROUND: Limited accessibility to providers may delay appropriate control of asthma exacerbations. The objective of our study is to estimate the contributors to the hospital/emergency department (ED) visits among adults with asthma focusing on the availability of healthcare providers. METHODS: We conducted a pooled cross-sectional analysis using the 2011-2013 Asthma Call-Back Survey linked with 2012-2016 Area Health Resource Files. We employed multivariable logistic regression with dichotomous outcomes of hospitalization and ED visits...
December 2, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27819161/performance-of-the-pegfilgrastim-on-body-injector-as-studied-with-placebo-buffer-in-healthy-volunteers
#2
Rajeshree S Joshi, Ogo I Egbuna, Alex S Cairns, Michael J Friedman, Bassam Abosaleem, Maureen T Reiner, Phuong Khanh Morrow
OBJECTIVE: The pegfilgrastim on-body injector (OBI) is a single-use, disposable, battery-powered injector that is designed to automatically deliver a single subcutaneous dose of pegfilgrastim beginning approximately 27 hours after activation and continuing over approximately 45 minutes. In this open-label study, we assessed performance of the OBI delivering placebo buffer in healthy volunteers. RESEARCH DESIGN AND METHODS: Healthy men and women aged 18-55 years, with a body mass index of 18-35 kg/m(2), were enrolled...
December 2, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27819152/blood-pressure-and-lipid-target-adherence-in-korean-patients-receiving-angiotensin-ii-receptor-blockers-statin-regimens
#3
Hyun-Jin Kim, Eugene Kim, Kyoung-Bok Min, Jin-Young Min
OBJECTIVES: Hypertension and dyslipidemia are important cardiovascular risk factors. Simultaneously controlling blood pressure (BP) and lipid levels is effective in preventing cardiovascular events and premature death. This study investigated the association between adherence to angiotensin II receptor blocker (ARB)/statin regimens and BP or low density lipoprotein-cholesterol (LDL-C) target attainment in Korean patients with concomitant hypertension and dyslipidemia. METHODS: In this retrospective, multicenter study, we collected case report forms (CRFs) of hypertensive patients with concomitant dyslipidemia who were prescribed an ARB/statin regimen between 1 April 2014 and 31 March 2015 from 51 outpatient clinics...
December 2, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27779433/patient-preferences-for-diabetes-treatment-attributes-and-drug-classes
#4
Emuella M Flood, Kelly F Bell, Marie C de la Cruz, France M Ginchereau-Sowell
OBJECTIVE: To identify which treatment attributes are most influential in determining patient preferences for diabetes treatments and explore patient preferences for diabetes drug classes. RESEARCH DESIGN AND METHODS: US adults with type 1 or type 2 diabetes completed an online adaptive conjoint analysis survey. The survey examined 14 attributes, including efficacy, regimen, and risk of common side effects and rare but serious adverse events. Respondents selected between hypothetical treatments with different attributes...
December 2, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27776432/statin-associated-muscle-symptoms-position-paper-from-the-luso-latin-american-consortium
#5
Andrei C Sposito, José Rocha Faria Neto, Luiz Sergio F de Carvalho, Alberto Lorenzatti, Alberto Cafferata, Gerardo Elikir, Eduardo Esteban, Enrique C Morales Villegas, Luiz Carlos Bodanese, Rodrigo Alonso, Alvaro J Ruiz, Viviane Z Rocha, Andre A Faludi, Hermes T Xavier, Ota Vio Rizzi Coelho, Marcelo H V Assad, Maria C Izar, Raul D Santos, Francisco A H Fonseca, Alberto Mello E Silva, Pedro Marques da Silva, Marcelo C Bertolami
In the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to a disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS have allowed a deeper understanding of the natural history and accurate incidence...
December 2, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27903084/assessment-of-corticosteroid-related-quality-of-care-measures-for-uc-and-cd-in-the-united-states-a-claims-data-analysis
#6
David T Rubin, Haridarshan Patel, Sherry Shi, Reema Mody
OBJECTIVE: To evaluate corticosteroid (CS)-related quality of care indicators in patients with ulcerative colitis (UC) and Crohn's disease (CD) in the US. METHODS: Adults diagnosed with UC or CD and prescription fills for an oral CS were identified from a large commercial US claims database (2005- 2013). Quality indicators included prolonged CS use (≥60 days), use of CS-sparing therapy, and bone loss assessment. State-level variations in quality of care indicators were estimated using logistic regression models adjusting for age, gender, insurance plan type, and CD severity...
December 1, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27893291/association-between-use-of-short-acting-benzodiazepines-and-migraine-occurrence-a-nationwide-population-based-case-control-study
#7
Tomor Harnod, Yu-Chiao Wang, Cheng-Li Lin, Chun-Hung Tseng
AIM: To evaluate the association between using benzodiazepines (BZDs) with short- or long-acting durations and migraine occurrence. METHODS: 9616 subjects aged older than 20 years and newly diagnosed with migraine between 2005 and 2011 comprised the migraine group, and 38464 subjects without migraine comprised the comparison group. The BZDs used in the subjects were dichotomously defined as short-acting (half-life ≤24 h) and long-acting substances. Logistic regression model was used to calculate the odds ratio (OR) of migraine associated with BZD exposure and other diseases...
November 28, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27892723/optimization-and-stratification-of-multiple-sclerosis-treatment-in-fast-developing-economic-countries-a-perspective-from-qatar
#8
Dirk Deleu, Boulenouar Mesraoua, Hisham El Khider, Beatriz Canibano, Gayane Melikyan, Hassan Al Hail, Noha Mhjob, Anjushri Bhagat, Faiza Ibrahim, Yolande Hanssens
OBJECTIVE: The introduction of disease-modifying therapies (DMTs) - with varying degrees of efficacy for reducing annual relapse rate and disability progression - has considerably transformed the therapeutic landscape of relapsing-remitting multiple sclerosis (RRMS). We aim to develop rational evidence-based treatment recommendations and algorithms for the management of clinically isolated syndrome (CIS) and RRMS conform to the healthcare system in a fast-developing economic country such as Qatar...
November 28, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27892720/association-between-chronic-pancreatitis-and-pyogenic-liver-abscess-a-nationwide-population-study
#9
Chih-Wei Tseng, Yu-Tso Chen, Cheng-Li Lin, Ji-An Liang
BACKGROUND: The relationship between chronic pancreatitis (CP) and subsequent pyogenic liver abscess (PLA) is not well understood. METHODS: We investigated the risk of PLA in patients with CP using inpatient claims data from the Taiwan National Health Insurance Program for the period 2000-2010, we identified 17,810 patients with chronic pancreatitis (CP group) and 71,240 patients without CP (non-CP group). Both cohorts were followed until a diagnosis of PLA, until they were censored from the study because of loss to follow-up, death, or termination of insurance, or until the study cut-off date of December 31, 2011...
November 28, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27882782/lidocaine-5-medicated-plaster-for-localized-neuropathic-pain-in-thoracic-surgical-patients
#10
Ulderico Freo, Carlo Ori, Francesco Ambrosio
Context Neuropathic pain is a common and distressing symptom in surgical thoracic patients. When it consistently presents with measurable sensory changes in a circumscribed area, neuropathic pain can be diagnosed as a localized neuropathic pain (LNP). Objective The purpose of this study was to report the efficacy of lidocaine 5% medicated plaster (Lido5%P) in the treatment of LNP in surgical thoracic patients. Methods We retrospectively reviewed the records of sixteen, cancer and noncancer, thoracic patients treated with Lido5%P for LNP...
November 24, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27882776/benefits-of-long-term-therapy-with-nucleos-t-ide-analogues-in-treatment-na%C3%A3-ve-patients-with-chronic-hepatitis-b
#11
Lai Wei, Jia-Horng Kao
OBJECTIVE: To assess the benefits of long-term nucleos(t)ide analogue (NA) therapy in reducing the severity and progression of liver disease in treatment-naïve patients with chronic hepatitis B (CHB). SCOPE: As complications of CHB, such as hepatic decompensation and hepatocellular carcinoma (HCC), take a long time to develop in patients with less advanced disease, the long-term benefits of NA therapy in such patients are more difficult to prove than short- or medium-term benefits...
November 24, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27826997/real-world-costs-of-ischemic-stroke-by-discharge-status
#12
F Mu, D Hurley, K A Betts, A J Messali, M Paschoalin, C Kelley, E Q Wu
OBJECTIVE: The objective of this study was to estimate the acute healthcare costs of ischemic stroke during hospitalization and the quarterly all-cause healthcare costs for the first year after discharge by discharge status. METHODS: Adult patients with a hospitalization with a diagnosis of ischemic stroke (ICD-9-CM: 434.xx or 436.xx) between 1 January 2006 and 31 March 2015 were identified from a large US commercial claims database. Patients were classified into three cohorts based on their discharge status from the first stroke hospitalization, i...
November 24, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27874307/single-center-single-dose-open-label-randomized-two-period-crossover-study-on-the-bioavailability-of-methotrexate-administered-using-a-novel-prefilled-needle-free-delivery-system-zeneo
#13
Boris Bienvenu, Achille Aouba, Jacques-Eric Gottenberg, Celine Verstuyft
OBJECTIVE: ZENEO (Crossject, Chenôve, France) is a needle-free injection device. We performed a pharmacokinetic study to investigate the bioequivalence of methotrexate administered subcutaneously using either ZENEO or a conventional needle and syringe. RESEARCH DESIGN AND METHODS: This was a single-dose, open-label, laboratory-blind, randomized crossover study performed in adult healthy volunteers. Each participant received two methotrexate injections (each 25 mg), one via ZENEO and one via conventional injection, with a 21-28 day wash-out interval between dosing...
November 22, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27869482/clinical-trial-transparency-update-an-assessment-of-the-disclosure-of-results-of-company-sponsored-trials-associated-with-new-medicines-approved-in-europe-in-2013
#14
Jacintha Sivarajah, Bryan R Deane
BACKGROUND: The objective of this study was to assess the timely disclosure of results of company-sponsored clinical trials related to all new medicines approved by the European Medicines Agency (EMA) during 2013. This is an extension of two previously reported studies of trials related to all new medicines approved in Europe in 2009, 2010 and 2011, and in 2012. The original study found that over a three year period over three-quarters of all trials were disclosed within 12 months and almost 90% were disclosed by the end of the study...
November 21, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27852119/albiglutide-a-weekly-glp-1-receptor-agonist-improves-glycemic-parameters-in-japanese-patients-with-type-2-diabetes-over-1-year-when-added-to-single-oral-antidiabetic-drugs
#15
Inaha Okuda, Timothy H Wilson, Lin Yue, Hiromu Nakajima, Molly C Carr, Maho Tsuboi, Antonio Nino, Yutaka Seino
OBJECTIVE: To evaluate the safety and efficacy of once-weekly albiglutide added to a single oral antidiabetic drug (OAD) in Japanese patients with inadequately controlled type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: In this phase 3, 1-year study (NCT01777282), patients (N = 374) received albiglutide 30 mg plus a single OAD (sulfonylurea [n = 120], biguanide [n = 67)], glinide [n = 65], thiazolidinedione [n = 61], or α-glucosidase inhibitor [n = 61])...
November 17, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27848271/improvement-in-condition-specific-and-generic-quality-of-life-outcomes-in-patients-with-knee-osteoarthritis-following-synvisc-one-results-from-the-lobras-study
#16
P Kearey, A E Popple, J Warren, T Davis, N Bellamy
OBJECTIVE: To evaluate the effectiveness of viscosupplementation with Synvisc-One in knee Osteoarthritis (OA), during routine clinical care, in a 52 week observational study. RESEARCH DESIGN AND METHODS: The LOBRAS study involved a one year long, multi-centre, quasi-experimental, repeated measures, observational study. Consenting patients in Australia fulfilling inclusion/exclusion criteria under the care of a medical specialist in routine clinical practice were enrolled...
November 16, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27848270/pathfinding-to-an-optimal-strategy-of-revascularization-at-primary-coronary-intervention-in-patients-with-multivessel-disease-a-network-meta-analysis-of-randomized-trials
#17
András Komócsi, Dániel Kehl, Fabrizio d'Ascenso, James DiNicolantonio, András Vorobcsuk
OBJECTIVES: In ST-segment elevation myocardial infarction (STEMI), current guidelines discourage treatment of the non-culprit lesions at the time of the primary intervention. Latest trials have challenged this strategy suggesting benefit of early complete revascularization. We performed a Bayesian multiple treatment network meta-analysis of randomized clinical trials (RCT) in STEMI on culprit-only intervention (CO) versus different timing multivessel revascularization, including immediate (IM), same hospitalization (SH) or later staged (ST)...
November 16, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27848268/use-of-intravenous-fluids-solutions-a-narrative-review
#18
N El Gkotmi, C Kosmeri, T D Filippatos, M S Elisaf
OBJECTIVE: Intravenous fluids are broadly categorized into colloids and crystalloids. The aim of this review is to present under a clinical point of view the characteristics of intravenous fluids that make them more or less appropriate either for maintaining hydration when enteral intake is contraindicated or for treating hypovolemia. METHODS: We considered randomized trials and meta-analyses as well as narrative reviews evaluating the effects of colloids or crystalloids in patients with hypovolemia or as maintenance fluids published in PubMed and Cochrane databases...
November 16, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27819150/systematic-literature-review-of-the-health-economic-implications-of-early-detection-by-screening-populations-at-risk-for-type-2-diabetes
#19
Thomas R Einarson, Basil G Bereza, Annabel Acs, Rasmus Jensen
BACKGROUND: Undetected/uncontrolled diabetes is associated with substantial morbidity and mortality and consequent costs. Early detection through screening identifies patients at risk, allowing for earlier treatment initiation. OBJECTIVES: To determine the economic impact of screening for type 2 diabetes (T2DM). DATA SOURCES: We systematically reviewed health economic analyses of screening programs for T2DM/pre-diabetes. STUDY ELIGIBILITY CRITERIA: Published between 2000 and 2015 in any language...
November 16, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27842443/clinical-update-on-benefit-versus-risks-of-oral-paracetamol-alone-or-with-codeine-still-a-good-option
#20
Hans Georg Kress, Gerald Untersteiner
BACKGROUND: After decades of worldwide use of paracetamol/acetaminophen as a popular and apparently safe prescription and over-the-counter medicine, the future role of this poorly understood analgesic has been seriously questioned by recent concerns about prenatal, cardiovascular (CV) and hepatic safety, and also about its analgesic efficacy. At the same time the usefulness of codeine in combination products has come under debate. METHODS: Based on a PubMed database literature search on the terms efficacy, safety, paracetamol, acetaminophen, codeine and their combinations up to and including June 2016, this clinical update reviews the current evidence of the benefit and risks of oral paracetamol alone and with codeine for mild-to-moderate pain in adults, and compares the respective efficacy and safety profiles with those of nonsteroidal anti-inflammatory drugs (NSAIDs)...
November 15, 2016: Current Medical Research and Opinion
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