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Rhinology

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https://www.readbyqxmd.com/read/29938715/influence-of-number-of-drugs-on-olfaction-in-the-elderly
#1
G Ottaviano, E Savietto, B Scarpa, A Bertocco, P Maculan, G Sergi, A Martini, E Manzato, G Marioni
BACKGROUND: The etiology of age-related olfactory loss is still unclear, but it has been claimed that polypharmacotherapy may contribute to olfactory dysfunction, particularly in the elderly, who are more likely to need multiple drugs. The present pilot study investigated the relationship between smell and the number and type of drugs taken in a group of elderly. METHODOLOGY: 50 elderly volunteers (over 64 years old) who were healthy from the sinonasal standpoint (SNOT-22 under 1) and had no cognitive impairments [Mini Mental State Examination (MMSE over 18) were administered the Screening 12 test and tested on their n-butanol olfactory threshold...
June 25, 2018: Rhinology
https://www.readbyqxmd.com/read/29911211/the-global-allergy-and-asthma-european-network-galen-rhinosinusitis-cohort-a-large-european-cross-sectional-study-of-chronic-rhinosinusitis-patients-with-and-without-nasal-polyps
#2
A Khan, G Vandeplas, T M T Huynh, V N Joish, L Mannent, P Tomassen, T Van Zele, L O Cardell, J Arebro, H Olze, U Foerster-Ruhrmann, M L Kowalski, A Olszewska-Ziaber, G Holtappels, N De Ruyck, C van Drunen, J Mullol, P W Hellings, V Hox, E Toskala, G Scadding, V J Lund, W J Fokkens, C Bachert
BACKGROUND: Chronic rhinosinusitis (CRS) is a common yet under-recognised chronic inflammatory disease of the nose and paranasal sinuses that is classified according to the presence (CRSwNP) or absence (CRSsNP) of nasal polyps. METHODS: This paper reports the methodology and descriptive results of the Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort. We established a large CRS cohort within the GALEN consortium (European FP6 research initiative) to identify inflammatory endotypes, the natural disease course, and its impact on health-related quality of life (HRQoL)...
June 17, 2018: Rhinology
https://www.readbyqxmd.com/read/29911210/tslp-regulates-eotaxin-1-production-by-nasal-epithelial-cells-from-patients-with-eosinophilic-crswnp
#3
W W Wang, D M Lu, M Zheng, J G Zhang, B Zhang
BACKGROUND: Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by Th2-skewed inflammation with eosinophilic infiltration. Thymic stromal lymphopoietin (TSLP) promotes the development of allergic inflammation. Although increased TSLP is found in eCRSwNP, little is known about whether TSLP regulates eotaxin-1 production, a potent eosinophil chemoattractant that recruits and activates eosinophils. OBJECTIVE: The aim of this study was to investigate the effects and mechanisms of TSLP in eotaxin-1 production in the eosinophilic inflammation of eCRSwNP...
June 17, 2018: Rhinology
https://www.readbyqxmd.com/read/29911209/the-effect-of-the-titanium-butterfly-implant-on-nasal-patency-and-quality-of-life
#4
S J A C van den Broek, N van Heerbeek
OBJECTIVE: The titanium butterfly implant seems to be a powerful technique to repair nasal valve insufficiency. However, the effect of these implants on nasal patency and quality of life has been controversial due to a lack of evidence. The purpose of this study is to evaluate the objective and subjective effect of the titanium butterfly implant on nasal patency and corresponding quality of life. METHODS: Nasal patency and quality of life of 32 patients undergoing a titanium butterfly implant were evaluated by measuring peak nasal inspiratory flow (PNIF) and completing three validated questionnaires: the NOSE, SNOT-22 and GBI, before surgery, six weeks and six months after surgery...
June 11, 2018: Rhinology
https://www.readbyqxmd.com/read/29785414/topical-nasal-decongestant-oxymetazoline-0-05-provides-relief-of-nasal-symptoms-for-12-hours
#5
H M Druce, D L Ramsey, S Karnati, A N Carr
BACKGROUND: Nasal congestion, often referred to as stuffy nose or blocked nose is one of the most prevalent and bothersome symptoms of an upper respiratory tract infection. Oxymetazoline, a widely used intranasal decongestant, offers fast symptom relief, but little is known about the duration of effect. METHODOLOGY: The results of 2 randomized, double-blind, vehicle-controlled, single-dose, parallel, clinical studies (Study 1, n=67; Study 2, n=61) in which the efficacy of an oxymetazoline (0...
May 22, 2018: Rhinology
https://www.readbyqxmd.com/read/29785413/multivariate-analysis-of-inflammatory-endotypes-in-recurrent-nasal-polyposis-in-a-chinese-population
#6
B Wei, F Liu, J Zhang, Y Liu, J Du, S Liu, N Zhang, C Bachert, J Meng
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical problem due to its propensity for recurrence. However, data on the frequency of CRSwNP recurrence after surgery in China are rare. METHODS: 78 CRSwNP patients undergoing functional endoscopic sinus surgery were followed-up for 8 years and classified into recurrent and non-recurrent groups. A cluster analysis of the CRSwNP based on inflammatory endotypes was performed, and the endotypes were secondarily matched with clinical phenotypes...
May 22, 2018: Rhinology
https://www.readbyqxmd.com/read/29785412/horizontal-lateral-lamella-as-a-risk-factor-for-iatrogenic-cerebrospinal-fluid-leak-clinical-retrospective-evaluation-of-24-cases
#7
A Preti, F Mozzanica, R Gera, S Gallo, J Zocchi, F Bandi, G Guidugli, F Ambrogi, A Yakirevitch, A Schindler, A Dragonetti, P Castelnuovo, F Ottaviani
BACKGROUND: Several authors highlighted the limitations of the Keros classification system in predicting intracranial entry risk. Recently, our group proposed a new classification system based on the angle formed between the lateral lamella of the cribriform plate (LLCP) and the continuation of an horizontal plane passing through the cribriform plate (Gera classification). The aim of this study was to analyze whether the risk of iatrogenic cerebrospinal fluid leak (CSF-L) was better predicted by Keros or Gera classification...
May 22, 2018: Rhinology
https://www.readbyqxmd.com/read/29719025/correlation-between-excessive-daytime-sleepiness-eds-and-self-reported-and-objective-nasal-characteristics
#8
K M Hoven, H J Aarstad, B Bjorvatn, E H Lundemo, S K Steinsvåg
BACKGROUND: The aim of the present study was to explore the relationship between excessive daytime sleepiness (EDS), Peak Nasal Inspiratory Flow (PNIF), and patient reported symptoms from the nose. METHOLOGY: Six hundred and fifty one consecutive patients referred to a hospital on suspicion of sleep related breathing disorder (SRBD) were included in the study. Daytime sleepiness was assessed by Epworth Sleepiness Scale (EpSS). Nasal airflow was measured with Peak Nasal Inspiratory Flow (PNIF)...
April 25, 2018: Rhinology
https://www.readbyqxmd.com/read/29656301/septoplasty-for-nasal-obstruction-due-to-a-deviated-nasal-septum-in-adults-a-systematic-review
#9
M M H T van Egmond, M M Rovers, A H J Tillema, N van Heerbeek
BACKGROUND: The status of current evidence for the effectiveness of septoplasty is unclear. This systematic review evaluates the effectiveness of a) septoplasty (with or without concurrent turbinate surgery) versus non-surgical management, and b) septoplasty with concurrent turbinate surgery versus septoplasty alone, for nasal obstruction due to a deviated nasal septum in adults. METHODOLOGY: Eligible for inclusion were randomised controlled trials and non-randomised designs comparing treatment strategies...
April 15, 2018: Rhinology
https://www.readbyqxmd.com/read/29626844/self-reported-anxiety-and-depression-are-unchanged-after-endoscopic-sinus-surgery-for-chronic-rhinosinusitis
#10
K N Adams, T A Schuman, C S Ebert, W You, M O Tomoum, B A Senior
BACKGROUND: Prior research has established that anxiety and depression, as measured by the Hospital Anxiety Depression Score (HADS), are strongly correlated with disease-specific quality of life (Rhinosinusitis Disability Index - RSDI) in chronic rhinosinusitis (CRS). We hypothesized that anxiety and depression would decrease after functional endoscopic sinus surgery (FESS), and furthermore that HADS would predict improvement in RSDI following surgery. METHODOLOGY: The study cohort from 2014 consisted of 99 CRS patients who underwent nasal endoscopy, RSDI, and HADS evaluation...
April 8, 2018: Rhinology
https://www.readbyqxmd.com/read/29561922/the-presence-of-interleukin-13-in-nasal-lavage-may-be-a-predictor-of-nasal-polyposis-in-pediatric-patients-with-cystic-fibrosis
#11
J Manji, A Thamboo, M Tacey, C Garnis, N K Chadha
BACKGROUND: Sinonasal disease is a common feature of cystic fibrosis (CF) and can cause significant morbidity in these patients. Our objective was to determine if CF individuals with concomitant nasal polyposis (NP) express a unique profile of inflammation and if so, whether these inflammatory cytokine mediators have predictive value in identifying these individuals for prompt management by an Otolaryngologist. METHODOLOGY: Nasal lavage samples and clinical outcomes of disease severity were obtained from thirty-eight pediatric CF individuals...
March 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29561921/nasal-symptoms-epithelial-injury-and-neurogenic-inflammation-in-elite-swimmers
#12
B Steelant, V Hox, L Van Gerven, E Dilissen, E Dekimpe, A Kasran, S Aertgeerts, V Van Belle, K Peers, L J Dupont, P W Hellings, D M Bullens, S F Seys
BACKGROUND: A high burden of lower airway symptoms is found in elite swimmers. To what extent elite swimmers suffer from upper airway symptoms and how these associate with nasal inflammation is less clear. We here aimed to evaluate upper airway symptoms and nasal inflammation in elite athletes. METHODOLOGY: Elite swimmers, indoor athletes and age-matched controls were recruited. Upper airway symptoms were assessed by sino-nasal outcome test (SNOT)-22 questionnaire...
March 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29561920/the-symptom-burden-of-autonomic-dysfunction-is-positively-associated-with-chronic-rhinosinusitis-status
#13
W C Chen, Y T Chang, S F Chen, W C Lin, Y Y Su, S D Luo
BACKGROUND: Dysregulation of the autonomic system can affect sinonasal physiological function and may exacerbate the symptom burden associated with rhinosinusitis. However, the association between autonomic dysfunction and chronic rhinosinusitis (CRS) has seldom been studied. Here, we investigated the relationship between autonomic dysfunction and CRS. METHODS: Patients with CRS who failed medical treatment were prospectively enrolled. All patients underwent pre-operative examinations and completed questionnaires, including the reflux symptom index (RSI) and the Sino-nasal Outcome Test-22 (SNOT-22)...
March 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29561919/reconstruction-of-frontal-defects-with-calvarial-grafts
#14
S Dova, P D Karkos, J Constantinidis
BACKGROUND: There are many options for the reconstruction of frontal sinus wall defect resulting from injury, neoplastic lesions and aesthetic deformities. These mainly include autogenous grafts, allogenous grafts, and alloplastic materials. The aim of the present study is to report the advantages of using autogenous calvarial bone grafts over other reconstruction techniques, in the reconstruction of frontal defects. METHODS: We describe 16 consecutive cases of anterior frontal sinus defects between 2004 and 2015, in which calvarial bone grafts were used...
March 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29550855/occurrence-of-occult-csf-leaks-during-standard-fess-procedures
#15
S Bucher, A Kugler, E Probst, L Epprecht, R S Stadler, D Holzmann, M B Soyka
OBJECTIVE: To determine the incidence of occult cerebrospinal fluid leaks (CSF) after functional endoscopic sinus surgery (FESS) and to evaluate the diagnostic performance of beta2-transferrin in blood-contaminated conditions. STUDY DESIGN: Prospective cohort study. METHODS: An analysis of 57 intraoperative samples using hydrogel 6 beta2-transferrin assay after FESS was undertaken. In case of CSF positive samples and continuing rhinorrhea, reanalysis after more than 1 year was conducted...
March 18, 2018: Rhinology
https://www.readbyqxmd.com/read/29550854/parkinson-disease-in-eldery-patients-lessons-from-odour-detection-thresholds-on-olfacto-trigeminal-interaction
#16
C Foguem, M Lemdani, C Huart
BACKGROUND: Human nasal chemosensation is mediated by two separate, though interacting sensory pathways: the trigeminal and olfactory systems. Trigeminal sensitivity and olfacto-trigeminal interactions have not yet been well studied in idiopathic Parkinsons disease (IPD). OBJECTIVES: The aim of this study was to assess odour detection thresholds in elderly IPD patients, and compare them to the odour detection thresholds of healthy controls. Finally, we investigated potential interactions between trigeminal and olfactory sensitivity...
March 18, 2018: Rhinology
https://www.readbyqxmd.com/read/29509831/eustachian-tube-symptoms-are-frequent-in-chronic-rhinosinusitis-and-respond-well-to-endoscopic-sinus-surgery
#17
A Maniakas, M Desrosiers, M H Asmar, M Al Falasi, L M Endam, C Hopkins, C Philpott, S Erskine, R Smith, S Kilty
BACKGROUND: Symptoms of Eustachian tube (ET) dysfunction are seldom assessed in patients with chronic rhinosinusitis (CRS). The Sino-Nasal Outcome Test (SNOT-22) quality-of-life tool includes two questions that specifically screen for symptoms of ET dysfunction (Ear Fullness; Ear Pain). OBJECTIVE: The purpose of this study was to determine the extent to which these ET symptoms were present in patients with CRS, and whether these symptoms respond to endoscopic sinus surgery (ESS)...
March 6, 2018: Rhinology
https://www.readbyqxmd.com/read/29509830/the-accessibility-of-topical-treatment-in-the-paranasal-sinuses-on-operated-cystic-fibrosis-patients-assessed-by-scintigraphy
#18
K Aanaes, M C Alanin, K G Nielsen, M Møller Jørgensen, C von Buchwald, N Høiby, H K Johansen, H H Johannesen, J Mortensen
BACKGROUND: Nasal irrigations with antibiotics are used to eradicate Pseudomonas aeruginosa from the upper airways in patients with cystic fibrosis (CF) and thereby avoid lung colonisations; nevertheless, the efficacy is uncertain. METHODOLOGY: The aim of this study was to investigate the accessibility and durability of solutions in the sinuses before and after sinus surgery. The participants irrigated their noses with radioactively marked saline and were evaluated using a dynamic SPECT/CT scan...
March 6, 2018: Rhinology
https://www.readbyqxmd.com/read/29509829/fluorescein-transit-test-time-as-a-tool-to-assess-lacrimal-pump-function-after-diode-laser-transcanalicular-dacryocystorhinostomy-and-external-dacryocysto-rhinostomy
#19
E D Feijo, R M Limongi, S Matayoshi
BACKGROUND: Dacryocystorhinostomy (DCR) is the gold standard surgical treatment for nasolacrimal duct obstruction. External DCR is the traditional approach (EXT-DCR); however, the advent of minimally invasive surgeries and the development of optic fiber and laser technologies have made it possible to perform laser transcanalicular DCR (T-DCR), a minimally invasive procedure. This study measured the fluorescein transit time (FTT) after EXT-DCR or T-DCR to evaluate the lacrimal drainage and lacrimal pump function after these two types of DCR...
March 6, 2018: Rhinology
https://www.readbyqxmd.com/read/29509828/lower-airway-flow-influences-peak-nasal-inspiratory-flow-in-school-aged-children
#20
H Pite, L Pimenta, A C Henriques, I Marques, C Camarinha, A V Lourenco, I Almeida, L M Borrego, M Morais-Almeida
BACKGROUND: Rhinitis and asthma frequently coexist. Peak nasal inspiratory flow (PNIF) objectively evaluates nasal obstruction. Lower airway flow's impact on PNIF has seldom been analysed in children. We aimed to study the associations between PNIF and: 1)forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) in children with allergic rhinitis and asthma and healthy controls; 2)allergic rhinitis and asthma control subjective evaluation. METHODS: Sequential assessments of PNIF before and after nasal decongestion and spirometry with bronchodilation test were performed in 65 children (6-12 years) with allergic rhinitis and asthma, and 24 gender, age-matched healthy controls...
March 6, 2018: Rhinology
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