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Rhinology

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https://www.readbyqxmd.com/read/28214914/the-impact-of-bitter-taste-receptor-genetics-on-culturable-bacteria-in-chronic-rhinosinusitis
#1
D I Rom, J M Christensen, R Alvarado, R Sacks, R J Harvey
BACKGROUND: Extra-oral bitter taste receptors have been associated with innate bacterial defence mechanisms. Genetic variation in T2R38 functionality has been shown to be associated with susceptibility to upper respiratory tract infections and chronic rhinosinusitis (CRS). We sought to independently assess the influence of bitter taste receptor genotype on the presence of culturable bacteria in the sinuses. METHODOLOGY: A cross-sectional analysis of patients with CRS undergoing surgery was performed...
February 19, 2017: Rhinology
https://www.readbyqxmd.com/read/28214913/assessment-of-efficacy-and-safety-of-the-herbal-medicinal-product-bno-1016-in-chronic-rhinosinusitis
#2
J Palm, I Steiner, D Abramov-Sommariva, A Ammendola, S Mitzenheim, H Steindl, M Wonnemann, C Bachert
BACKGROUND: The objective of this clinical trial (CRS-02) was to assess the efficacy, safety and tolerability of two dosages of the herbal medicinal product BNO 1016 (Sinupret extract) in patients with chronic rhinosinusitis (CRS). METHODOLOGY: 929 patients suffering from CRS were enrolled in this randomised placebo-controlled trial with a treatment period of 12 weeks. The primary endpoint was the mean Major Symptom Score (MSS) in week 8 and week 12 compared to placebo...
February 19, 2017: Rhinology
https://www.readbyqxmd.com/read/28214353/association-of-gastro-oesophageal-reflux-and-chronic-rhinosinusitis-systematic-review-and-meta-analysis
#3
S R Leason, H P Barham, G Oakley, J Rimmer, J M DelGaudio, J M Christensen, R Sacks, R J Harvey
INTRODUCTION: Gastro-oesophageal reflux disease (GORD) has been implicated in the development of chronic rhinosinusitis (CRS). The association of GORD with CRS is systematically assessed from the medical literature. METHODOLOGY: Embase and MEDLINE were searched using a comprehensive strategy limited to English language and Human subjects. Any study with original data on the experimental, diagnostic, treatment or prognostic association of CRS with GORD was included...
February 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28214352/gastro-oesophageal-reflux-in-patients-with-chronic-rhino-sinusitis-investigated-with-multichannel-impedance-ph-monitoring
#4
(no author information available yet)
INTRODUCTION: The pathophysiology of chronic rhinosinusitis (CRS) is unclear. It has been discussed for decades whether gastro-oesophageal reflux (GOR) may be a contributing factor for some patients. The aim of the present study was to evaluate the level of GOR in an unselected group of patients with CRS using multichannel impedance-pH monitoring. METHODS: Consecutive patients with CRS diagnosed using the EPOS2012 criteria, completed questionnaires on GOR symptoms and were offered 24-h multichannel intraluminal impedance (MII)-pH monitoring...
February 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28214351/evidence-based-and-precision-medicine-two-of-a-kind
#5
W J Fokkens
In the last two decades, an enormous expansion of evidence has been produced in upper airway research. When writing the first EPOS document in 2005 only 5 RCT per year were performed in the area of CRS, in 2007 this changed to 25 per year and it became even higher in the recent years. Randomized Controlled Trials (RCTs) are the "gold standard" for evaluating treatment outcomes providing information on treatments "efficacy". To make life easier for clinicians, systematic reviews and meta-analysis further condense the available evidence...
February 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28064338/-unknown-title
#6
V J Lund, Y Darby, J Rimmer, M Amin, S Husain
INTRODUCTION: Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disease characterized by recurrent epistaxis, mucocutaneous telangiectasia and visceral arteriovenous malformations. The nosebleeds can be life-threatening and in these circumstances, radical treatment is required. METHODS: Since 1994, closure of the nose has been undertaken to prevent severe nasal bleeding in patients meeting specific selection criteria. Outcome data collected on this cohort pre- and post-operatively is available for analysis...
January 8, 2017: Rhinology
https://www.readbyqxmd.com/read/28060384/effects-of-functional-endoscopic-sinus-surgery-on-the-acoustics-of-the-sinonasal-tract
#7
M Havel, S Becker, M Schuster, T Johnson, A Maier, J Sundberg
BACKGROUND: Nasal and paranasal cavities are supposed to contribute substantially to the vocal tract resonator properties. However, their acoustical effects as well as the effects of sinus surgery on the voice remain unclear. In this work we investigate resonance phenomena of paranasal sinuses prior to and after various rhinosurgical procedures in cadaveric human sinonasal tracts and corresponding 3D casts. METHODOLOGY: Nasal and paranasal cavities of formalin-preserved cadavers and corresponding 3D replicas were excited by sine-tone sweeps from an earphone placed in the epipharynx...
January 6, 2017: Rhinology
https://www.readbyqxmd.com/read/28060383/clinimetric-properties-of-the-glasgow-health-status-inventory-glasgow-benefit-inventory-peak-nasal-inspiratory-flow-and-4-phase-rhinomanometry-in-adults-with-nasal-obstruction
#8
M M H T van Egmond, N van Heerbeek, E L M Ter Haar, M M Rovers
BACKGROUND: The validity of many measurement instruments frequently used in rhinology is unknown. This study describes clinimetric properties of well-known subjective and objective outcomes, i.e., the Glasgow Health Status Inventory, Glasgow Benefit Inventory, Peak Nasal Inspiratory Flow, and 4-Phase Rhinomanometry, in adults with nasal obstruction. METHODOLOGY: Construct validity and responsiveness were determined in 111 patients. Inter-rater and intra-rater reliability were analysed in 30 patients...
January 6, 2017: Rhinology
https://www.readbyqxmd.com/read/28040824/effects-of-olfactory-training-a-meta-analysis
#9
A Sorokowska, E Drechsler, M Karwowski, T Hummel
The neural plasticity of the olfactory system offers possibilities of treatment in terms of stimulation of the sense of smell, and different studies have suggested effectiveness of smell training, i.e., daily exposition to certain odors. To obtain reliable and precise estimates of overall treatment benefit on the olfactory function, we meta-analyzed the effects of smell training reported in 13 previous studies. We analyzed the smell training effectiveness across three different olfactory abilities, smell identification, discrimination and threshold for odor detection...
January 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28029166/influence-of-cooling-face-masks-on-nasal-air-conditioning-and-nasal-geometry
#10
J Lindemann, T Hoffmann, A Koehl, E M Walz, F Sommer
INTRODUCTION: Nasal geometries and temperature of the nasal mucosa are the primary factors affecting nasal air conditioning. Data on intranasal air conditioning after provoking the trigeminal nerve with a cold stimulus simulating the effects of an arctic condition is still missing. The objective was to investigate the influence of skin cooling face masks on nasal air conditioning, mucosal temperature and nasal geometry. METHODS: Standardized in vivo measurements of intranasal air temperature, humidity and mucosal temperature were performed in 55 healthy subjects at defined detection sites before and after wearing a cooling face mask...
December 28, 2016: Rhinology
https://www.readbyqxmd.com/read/28026838/predictors-of-unanticipated-admission-within-30-days-of-outpatient-sinonasal-surgery
#11
I Gengler, L Carpentier, X Pasquesoone, D Chevalier, G Mortuaire
OBJECTIVES: To identify predictive factors of readmission after day-case rhinologic surgery. METHODS: A 2-year retrospective chart review of patients scheduled for ambulatory sinonasal surgery in a tertiary medical center was conducted. The operating room and the anesthetic files were screened to identify demographic data, types of procedure, comorbidities and post-operative complications. RESULTS: From January 2014 to January 2016, 924 outpatient sinonasal procedures were identified...
December 27, 2016: Rhinology
https://www.readbyqxmd.com/read/28026837/trigeminal-sensitivity-in-chronic-rhinosinusitis-topographical-di-erences-and-the-e-ect-of-surgery
#12
S C Poletti, M Cuevas, S Weile, T Hummel
INTRODUCTION: Little is known on endonasal trigeminal sensitivity in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The aim of our study was to investigate changes in trigeminal sensitivity in patients with CRSwNP and the effect of functional endoscopic sinus surgery (FESS) on trigeminal perception. METHODS: A prospective study was performed to investigate the trigeminal sensitivity at three different locations within the nose (anterior septum, anterior lateral wall, middle turbinate) using electrical stimuli...
December 27, 2016: Rhinology
https://www.readbyqxmd.com/read/28025987/toll-like-receptor-activation-by-sino-nasal-mucus-in-chronic-rhinosinusitis
#13
K Biswas, A Chang, M Hoggard, F J Radcliff, Y Jiang, M W Taylor, R Darveau, R G Douglas
BACKGROUND: The sino-nasal disease chronic rhinosinusitis (CRS) is primarily an inflammatory condition that manifests in several ways. However, the aetiology of this complex disease is poorly understood. The aim of this study was to explore the association between toll-like receptor (TLR) activation, host immune response and sino-nasal mucus in healthy and diseased patients. METHODS: The activation of TLR2/1 and TLR4 by sino-nasal mucus from 26 CRS patients and 10 healthy controls was measured...
December 27, 2016: Rhinology
https://www.readbyqxmd.com/read/28025986/responsiveness-and-reliability-of-the-sinus-control-test-in-chronic-rhinosinusitis
#14
P Kohli, Z M Soler, K A Storck, A Shahangian, S M Banglawala, R J Schlosser
BACKGROUND: The Sinus Control Test (SCT) is a patient-reported questionnaire designed to help physicians identify sub-optimally controlled chronic rhinosinusitis (CRS). This study measures responsiveness to surgery and reliability of the SCT. METHODOLOGY: Adults meeting diagnostic criteria for CRS were recruited from rhinology clinics at a tertiary academic institution. To measure responsiveness, the SCT was administered at baseline and at least 3 months after surgery to 62 CRS patients...
December 27, 2016: Rhinology
https://www.readbyqxmd.com/read/28025985/quality-of-life-after-primary-septorhinoplasty-in-deviated-and-non-deviated-nose-measured-with-roe-froi-17-and-sf-36
#15
O C Bulut, F Wallner, R Hohenberger, P K Plinkert, I Baumann
BACKGROUND: Quality of life measurements are gaining in importance. The present study was conducted with the aim to compare patient satisfaction after septorhinoplasty according to their preoperative nasal deformity. METHODS: The patients completed two disease-specific questionnaires before their surgery: the Functional Rhinoplasty Outcome Inventory (FROI-17), the Rhinoplasty Outcome Evaluation (ROE) and as a general instrument, the Short Form 36 Health Survey (SF-36)...
December 27, 2016: Rhinology
https://www.readbyqxmd.com/read/28019644/allergic-rhinitis-severity-can-be-assessed-using-a-visual-analogue-scale-in-mild-moderate-and-severe
#16
A Del Cuvillo, V Santos, J Montoro, J Bartra, I Davila, M Ferrer, I Jauregui, J Sastre, J Mullol, A Valero
BACKGROUND: Allergic rhinitis is a global healthcare problem due to its high prevalence, impact on individuals and socioeconomic burden for the nations. Allergic rhinitis severity evaluation is the key to a correct treatment, prevention of comorbidities and improving the quality of life of patients. This evaluation should be made with a simple, easy, fast but accurate and reliable methodology, both in a primary care and specialist setting. The visual analogue scale (VAS) meets all requirements to be the ideal tool to assess allergic rhinitis severity and has already been validated by using a single cut-off point, but this classification in two degrees of severity suffer from not allocating the patients uniformly and from giving a blind interval to classify the patients when the score is between 5 to 6 cm...
December 26, 2016: Rhinology
https://www.readbyqxmd.com/read/28019643/sleep-quality-improves-with-endoscopic-sinus-surgery-in-patients-with-chronic-rhinosinusitis-and-nasal-polyposis
#17
M Värendh, A Johannisson, H Hrubros-Strøm, M Andersson
BACKGROUND: Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) is a chronic disease that has a major impact on generic and disease-specific quality of life. Little is known about the influence of CRSwNP on sleep and what effect surgery for CRSwNP has on sleep quality. The aim of the study was to investigate sleep quality in patients with CRSwNP before and after endoscopic surgery. METHODOLOGY: Forty-two patients filled out four validated sleep questionnaires and one sino/nasal, disease specific quality of life questionnaire before surgery and three months later...
December 26, 2016: Rhinology
https://www.readbyqxmd.com/read/28013326/chronic-rhinosinusitis-new-understanding-of-specific-and-general-quality-of-life-scores
#18
A Slovick, M Cornet, P Surda, P V Tomazic
Our goal in treating chronic rhinosinusitis (CRS) is to reduce sinonasal symptoms and improve quality of life (QoL). In patients with CRS, sinonasal symptoms have a significant impact on QoL. Various validated measures exist to quantify QoL such as the 22-item Sinonasal Outcomes Test (SNOT- 22) and MSNOT-20 Young Persons Questionnaire (MSYPQ) specific to CRS, while others measure general QoL, such as the EuroQol 5-Dimensional general health-related QoL survey (EQ5D).
December 1, 2016: Rhinology
https://www.readbyqxmd.com/read/27665614/symptoms-of-chronic-rhinosinusitis-differentially-impact-general-health-related-quality-of-life
#19
L P Hoehle, K M Phillips, R W Bergmark, D S Caradonna, S T Gray, A R Sedaghat
BACKGROUND: The degree to which different sinonasal symptoms contribute to the overall quality of life (QOL) detriment in chronic rhinosinusitis (CRS) patients remains unknown. In this study we sought to characterize the effect of different CRS symptoms on the general health-related QOL in patients. METHODOLOGY: We performed a prospective cross-sectional study of 131 adult patients with CRS. Sinonasal symptoms were evaluated using the 22-item Sinonasal Outcomes Test (SNOT-22) and general health-related QOL was evaluated using the EuroQol 5-Dimensional general health-related QOL survey (EQ5D) and visual analog scale (EQ5D-VAS)...
December 1, 2016: Rhinology
https://www.readbyqxmd.com/read/27592074/managing-nasal-valve-compromise-patients-with-nasal-dilators-objective-vs-subjective-parameters
#20
G Lekakis, E Dekimpe, B Steelant, P W Hellings
INTRODUCTION: Patients suffering from nasal obstruction due to nasal valve compromise may benefit from a nasal dilator. Several devices for widening of the external/internal nasal valve region can be applied endonasally (Airmax, Nasanita, Nozovent) or externally (Breathe Right). MATERIALS AND METHODS: 100 patients suffering from nasal obstruction due to external or internal nasal valve compromise were involved in this study. All patients were evaluated for nasal obstruction with visual analogue scores (VAS) and peak nasal inspiratory flow (PNIF) measurements before and after the application of 4 nasal dilators...
December 1, 2016: Rhinology
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