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Rhinology

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https://www.readbyqxmd.com/read/28888026/-unknown-title
#1
T Hussain, S Mattheis, N Dominas, B Hoing, S Lang, B A Stuck
INTRODUCTION: Surgery is the primary treatment option for squamous cell carcinomas of the nasal cavity (NCSCC). Nodal involvement is rare at the time of initial diagnosis, and the role of diagnostic neck dissection as well as potential adjuvant irradiation of the neck remains controversial. The objective of this study was to assess the oncologic outcomes of patients with NCSCC with special emphasis on cervical lymph node treatment and recurrence. METHODS: 37 previously untreated patients were included in this study...
September 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28888025/comparison-of-different-endoscopic-scoring-systems-in-patients-with-chronic-rhinosinusitis-reliability-validity-responsiveness-and-correlation
#2
L Zhang, L H Zhang
OBJECTIVES: Previous studies have proposed various endoscopic scoring systems to assess disease severity of patients with chronic rhinosinusitis (CRS). However, those assessments have not been validated. This study was designed to assess the Modified Lund - Kennedy (MLK) and the discharge, inflammation, and polyps/oedema (DIP) endoscopic scoring systems in patients with CRS. METHODS: A prospective study including 144 patients who underwent functional endoscopic sinus surgery (FESS)...
September 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28888024/airflow-and-symptom-outcomes-between-allergic-and-non-allergic-rhinitis-patients-from-turbinoplasty
#3
K Parthasarathi, J M Christensen, R Alvarado, H P Barham, R Sacks, R J Harvey
BACKGROUND: Inferior turbinate procedures are applied to relieve medically refractory nasal obstruction. However, the nature of congestion differs between allergic(AR) and non-allergic rhinitis(NAR). This study compares surgical outcomes between AR and NAR patients. METHODOLOGY: A case-control study of patients undergoing turbinate with or without septoplasty surgery for nasal obstruction was performed. Patient reported outcomes were: nasal obstruction, global nasal function(GNF), and sino-nasal outcome test(SNOT-22) with rhinitis, facial symptom, sleep and psychological sub-scores...
September 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28887880/allergy-rhinitis-similarities-and-differences-between-children-and-adults
#4
A Izquierdo-Dominguez, I Jauregui, A Del Cuvillo, J Montoro, I Davila, J Sastre, J Bartra, M Ferrer, I Alobid, J Mullol, A L Valero
BACKGROUND: Allergic rhinitis (AR) is a highly prevalent disease worldwide. Although a number of studies have described AR, no studies compared children and adult AR populations. The objective was to compare the AR characteristics between two AR cohorts of children and adults. METHODS: Two AR cohorts (children and adults) from Spain were studied through observational cross-sectional multicentre studies. AR was classified based on classical (allergen exposure), original (o-ARIA), and modified (m-ARIA) ARIA criteria...
September 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28887879/orbital-floor-fracture-repair-the-endonasal-approach
#5
T Kuhnel, H Jagle, W Hosemann, R Weber, V Vielsmeier
To avoid the dangers associated with lower eyelid approaches to the orbital floor and to improve visualization, we propose an endoscopic procedure for orbital floor fracture reduction and osteosynthesis using endonasal access via the medial maxillary sinus wall. The technique of endoscopic, endonasal transantral surgery is described, together with a retrospective analysis of 17 patients who had undergone this surgical procedure in the Department of Otorhinolaryngology, University of Regensburg, between July 2013 and June 2016...
September 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28821888/risk-factors-for-epistaxis-in-patients-followed-in-general-practices-in-germany
#6
D U Seidel, L Jacob, K Kostev, A M Sesterhenn
<p>BACKGROUND: The goal of the present study was to analyze the risk factors for epistaxis in patients followed in general practices in Germany.</p> <p>METHODS: The current study sample included patients aged 18 years or older who received a first epistaxis diagnosis between January 2012 and December 2016 (index date). Epistaxis patients and controls without epistaxis were matched (1:1) on the basis of age, gender, insurance status and physician. </p> <p>RESULTS: A total of 16,801 patients with epistaxis and 16,801 control subjects were included in this study...
August 19, 2017: Rhinology
https://www.readbyqxmd.com/read/28689218/allergic-inflammation-is-exacerbated-by-allergen-induced-type-2-innate-lymphoid-cells-in-a-murine-model-of-allergic-rhinitis
#7
L Lin, F Dai, J J Wei, X Y Tang, Z Chen, G B Sun
BACKGROUND: Group 2 innate lymphoid cells (ILC2s) represent a new innate effector leukocyte population that mediates type-2 immune response. However, the contribution of ILC2s to allergic rhinitis (AR) is currently not well defined. OBJECTIVE: To evaluate the potential existence and function of allergen-induced ILC2s in the experimental AR. METHODS: We established a murine model of AR using ovalbumin (OVA) and aluminium hydroxide. The OVA-induced ILC2s were sorted and purified from the mouse nasal-associated lymphoid tissue (NALT)...
July 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28687815/postoperative-long-term-morbidity-of-extended-endoscopic-maxillectomy-for-inverted-papilloma
#8
G Bertazzoni, R Accorona, A Schreiber, G Pietrobon, A Karligkiotis, E Fazio, P Castelnuovo, P Nicolai
BACKGROUND: Extended endoscopic maxillectomy (Sturmann-Canfield procedure) allows full visualization of the maxillary sinus by sectioning the lacrimal duct and removing the medial part of the anterior maxillary wall. The aim of this study is to evaluate the morbidity of Sturmann-Canfield procedure in patients treated for inverted papilloma. METHODOLOGY: The clinical records of all patients treated with a Sturmann-Canfield procedure for inverted papilloma from October 2000 to September 2015 at two teaching hospitals were reviewed...
July 8, 2017: Rhinology
https://www.readbyqxmd.com/read/28687814/the-persistence-of-intracellular-staphylococcus-aureus-in-the-sinuses-a-longitudinal-study
#9
J Ou, A Bassiouni, A Drilling, A J Psaltis, S Vreugde, P J Wormald
BACKGROUND: Staphylococcus aureus (S. aureus) can reside within the sinonasal mucosa in chronic rhinosinusitis patients and causes recurrent infections. Within the host cell, S. aureus can evade host immune detection enabling its own survival. We hypothesise that S. aureus can persist within the sinonasal epithelium for a prolonged period without immune activation. METHODOLOGY: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) undergoing two sinus surgeries were included...
July 8, 2017: Rhinology
https://www.readbyqxmd.com/read/28667737/periostin-as-a-marker-of-mucosal-remodelling-in-chronic-rhinosinusitis
#10
J A Ebenezer, J M Christensen, B G Oliver, R A Oliver, G Tjin, J Ho, A R Habib, J Rimmer, R Sacks, R J Harvey
BACKGROUND: Although extracellular matrix (ECM) proteins are associated with irreversible lower airway changes, the relationship with upper airway remodelling which occurs during chronic rhinosinusitis (CRS) is poorly understood. This study assessed the expression of ECM proteins periostin, fibulin-1, fibronectin and collagenIV in nasal mucosa of patients with and without histologic features of remodelling. METHODS: A cross-sectional study of sinonasal mucosal biopsies taken from patients, undergoing surgery for CRS was performed, where patients were grouped according to remodelling, defined by basement membrane thickening (BMT over 7...
July 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28647751/chronic-rhinosinusitis-severity-is-associated-with-need-for-asthma-related-systemic-corticosteroids
#11
K M Phillips, L P Hoehle, R W Bergmark, A P Campbell, D S Caradonna, S T Gray, A R Sedaghat
BACKGROUND: Chronic rhinosinusitis (CRS) is highly prevalent in patients with asthma. However, no study has evaluated the effect of CRS severity on asthma-related oral corticosteroid use - a marker of poor asthma control and prognosis. We therefore sought to evaluate the association between CRS severity and asthma-related oral corticosteroid use. METHODOLOGY: Prospective cross-sectional study of 110 adult asthmatic CRS patients. CRS severity was measured using the 22-item Sinonasal Outcomes Test (SNOT-22) and Lund-Kennedy endoscopy score...
June 25, 2017: Rhinology
https://www.readbyqxmd.com/read/28647750/misdiagnosed-paranasal-gossypiboma-a-10-year-experience-with-21-cases-at-a-tertiary-center
#12
P Z Wu, W Sun, Y H Wen, R Q Ma, X L Zhu, W P Wen
BACKGROUND: Different from rhinoliths, the paranasal gossypiboma is a foreign body, such as a surgical sponge, left in the nasal cavity. It is a rare, frequently misdiagnosed disease that has rarely been reported. We summarize its clinical characteristics, management, and possible risk factors. METHODOLOGY: We reviewed medical records of confirmed paranasal gossypibomas at a tertiary medical center between 2005 and 2015. Clinical symptoms, age, sex, anatomic sites, endoscopic photography, computed tomography, intraoperative findings, and past medical history were reviewed...
June 25, 2017: Rhinology
https://www.readbyqxmd.com/read/28865140/the-comparison-of-nasal-surgery-and-cpap-on-daytime-sleepiness-in-patients-with-osas
#13
M Tagaya, H Otake, K Suzuki, F Yasuma, H Yamamoto, A Noda, Y Nishimura, M Sone, T Nakashima, S Nakata
OBJECTIVE: Residual sleepiness after continuous positive airway pressure (CPAP) is a critical problem in some patients with obstructive sleep apnea syndrome (OSAS). However, nasal surgery is likely to reduce daytime sleepiness and feelings of unrefreshed sleep. The aim of this study is to clarify the effects of nasal surgery and CPAP on daytime sleepiness. METHODOLOGY: This is a retrospective and matched-case control study. The participants were consecutive 40 patients with OSAS who underwent nasal surgery (Surgery group) and 40 matched patients who were treated with CPAP (CPAP group)...
September 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28865115/paving-the-future-of-rhinosinusitis-care
#14
P W Hellings
Novel insights into the pathophysiology of chronic rhinosinsusitis (CRS) will lead to endo-type driven treatment and reduce oral corticosteroid treatment.
September 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28624844/the-effect-of-endoscopic-sinus-surgery-on-quality-of-life-and-absenteeism-in-patients-with-chronic-rhinosinuitis-a-multi-centre-study
#15
P Sahlstrand-Johnson, C Hopkins, B Ohlsson, M Ahlner-Elmqvist
BACKGROUND: Chronic rhinosinusitis with and without nasal polyps (CRSw/sNP) are common conditions decreasing health-related quality of life (HRQOL). Individual symptoms capable of predicting outcome after endoscopic sinus surgery (ESS) are poorly defined, and the indirect costs of CRS is rarely reported in Europe. METHODOLOGY: Patients with CRSw/sNP admitted for ESS were prospectively enrolled. Patients completed the 22 Sinonasal Outcome Test (SNOT-22), the short-form 36-item questionnaire (SF-36), a Visual Analogue Scale (VAS) and reported CRS-related absenteeism pre- and post-operatively...
June 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28623665/position-paper-on-olfactory-dysfunction
#16
T Hummel, K L Whitcroft, P Andrews, A Altundag, C Cinghi, R M Costanzo, M Damm, J Frasnelli, H Gudziol, N Gupta, A Haehner, E Holbrook, S C Hong, D Hornung, K B Hüttenbrink, R Kamel, M Kobayashi, I Konstantinidis, B N Landis, D A Leopold, A Macchi, T Miwa, R Moesges, J Mullol, C A Mueller, G Ottaviano, G C Passali, C Philpott, J M Pinto, V J Ramakrishnan, P Rombaux, Y Roth, R A Schlosser, B Shu, G Soler, P Stjärne, B A Stuck, J Vodicka, A Welge-Luessen
BACKGROUND: Olfactory dysfunction is an increasingly recognised condition, associated with reduced quality of life and major health outcomes such as neurodegeneration and death. However, translational research in this field is limited by heterogeneity in methodological approach, including definitions of impairment, improvement and appropriate assessment techniques. Accordingly, effective treatments for smell loss are limited. In an effort to encourage high quality and comparable work in this field, among others, we propose the following ideas and recommendations...
June 17, 2017: Rhinology
https://www.readbyqxmd.com/read/28604844/blocked-noses
#17
W J Fokkens
This issue of our Journal contains interesting papers about blocked noses. Nasal obstruction is one of the most common reasons that patients visit their doctors, general practitioners and otorhinolaryngologists alike and has a significant impact on the quality of life of patients. Blockage is an important outcome of disease not only in nasal disease, but also in rhinosinusitis.
June 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28501886/rhinophototherapy-in-chronic-rhinosinusitis-a-double-blind-randomized-placebo-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
N Dulguerov, N Guinand, D Courvoisier, B N Landis, J S Lacroix, C Hauser
BACKGROUND: This study evaluated the efficacy of rhinophototherapy in patients with chronic rhinosinusitis (CRS) without nasal polyps. METHOD: In this randomized double-blind, placebo-controlled trial, CRS patients (n=50) received either mixed visible and ultraviolet (UVA and UVB) light source application (mUV/VIS) or visible light alone that served as placebo. Both groups were treated for 3 weeks. RESULTS: Results in the rhinophototherapy and placebo group were not significantly different and failed to reduce patient-reported outcomes measures (Rhinosinusits Disability Index, Visual Analogic Scale of symptom severity) and objective scores (rhinomanometry, olfactory thresholds, nasal Nitic Oxide concentrations), immediately and one month after treatment...
June 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28501884/the-effect-of-systemic-treatments-on-periostin-expression-reflects-their-interference-with-the-eosinophilic-inflammation-in-chronic-rhinosinusitis-with-nasal-polyps
#19
E De Schryver, L Derycke, L Calus, G Holtappels, P W Hellings, T Van Zele, C Bachert, P Gevaert
BACKGROUND: Periostin is a recently discovered biomarker for eosinophilic inflammation. Chronic rhinosinusitis with nasal polyps is a T-helper 2-skewed chronic inflammatory airway disease. Medical treatments aim to relieve symptoms and maintain clinical control by interfering with the inflammatory cascade. The effect on nasal and serum periostin levels is however yet unknown. We aimed to evaluate the effect of omalizumab, mepolizumab, methylprednisolone and doxycycline on nasal and systemic periostin expression...
June 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28492611/the-effect-of-topical-treatments-for-crs-on-the-sinonasal-epithelial-barrier
#20
M Ramezanpour, A Rayan, J L P Smith, S Vreugde
BACKGROUND: Several topical treatments are used in the management of Chronic Rhinosinusitis (CRS), some of which the safety and efficacy has yet to be determined. The purpose of this study was to investigate the effect of commonly used topical treatments on the sinonasal epithelial barrier. METHODS: Normal saline (0.9% Sodium Chloride), hypertonic saline (3% Sodium Chloride), FESS Sinu-Cleanse Hypertonic, FLO Sinus Care and Budesonide 1 mg/ 2 ml were applied to the apical side of air-liquid interface (ALI) cultures of primary human nasal epithelial cells (HNECs) from CRS patients (n=3) and non-CRS controls (n=3) for 24 hours...
June 1, 2017: Rhinology
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